9483:TUSC3
gene id: 9483:TUSC3
uniprot id: A0A5F4VZK7
uniprot id: A0A5F4W1Z3
uniprot id: F6T1G7
uniprot id: F7C9S5
uniprot id: U3BNG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:PLXNC1
gene id: 9483:PLXNC1
uniprot id: U3CZ51
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:KRR1
gene id: 9483:KRR1
uniprot id: F7HXY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRR1 family.
messages: nucleolus

9483:NDRG1
gene id: 9483:NDRG1
uniprot id: U3C0J9
names: Similarity
messages: Belongs to the NDRG family.

9483:TM9SF1
gene id: 9483:TM9SF1
uniprot id: F6PMW5
uniprot id: U3F079
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CORO1A
gene id: 9483:CORO1A
uniprot id: U3FGQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

9483:BMPR1B
gene id: 9483:BMPR1B
uniprot id: F6REM9
uniprot id: F7IS54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:OR6P1
gene id: 9483:OR6P1
uniprot id: F7HXK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:HEBP1
gene id: 9483:HEBP1
uniprot id: F7IJ77
names: Similarity
messages: Belongs to the HEBP family.

9483:MTMR4
gene id: 9483:MTMR4
uniprot id: U3DNI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9483:NLGN1
gene id: 9483:NLGN1
uniprot id: U3FSR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9483:MMP16
gene id: 9483:MMP16
uniprot id: A0A2R8M760
names: Similarity
messages: Belongs to the peptidase M10A family.

9483:VTI1A
gene id: 9483:VTI1A
uniprot id: A0A2R8MZ66
uniprot id: F7IIA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9483:MPPED2
gene id: 9483:MPPED2
uniprot id: U3BEC4
names: Similarity
messages: Belongs to the UPF0046 family.

9483:TPP1
gene id: 9483:TPP1
uniprot id: F7CCS9
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Melanosome

9483:SPRR3
gene id: 9483:SPRR3
uniprot id: A0A8I3XA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornifin (SPRR) family.
messages: Cytoplasm

9483:UBE2K
gene id: 9483:UBE2K
uniprot id: F7HJ73
uniprot id: F7HJG5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:EVX2
gene id: 9483:EVX2
uniprot id: A0A8I3W8Y3
names: Subcellular Location Annotation
messages: Nucleus

9483:ABR
gene id: 9483:ABR
uniprot id: U3FNW8
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9483:DOP1A
gene id: 9483:DOP1A
uniprot id: U3DQC0
uniprot id: U3F9R1
names: Similarity
messages: Belongs to the dopey family.

9483:HOXB3
gene id: 9483:HOXB3
uniprot id: F7DL62
names: Subcellular Location Annotation
messages: Nucleus

9483:OR52J3
gene id: 9483:OR52J3
uniprot id: B0VXA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:GNAI1
gene id: 9483:GNAI1
uniprot id: F7IEH0
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9483:PSMD1
gene id: 9483:PSMD1
uniprot id: F6PMK9
uniprot id: U3ENA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9483:MTMR8
gene id: 9483:MTMR8
uniprot id: F7H0W9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9483:SLC43A3
gene id: 9483:SLC43A3
uniprot id: F7C5I5
names: Subcellular Location Annotation
messages: Membrane

9483:ZDHHC7
gene id: 9483:ZDHHC7
uniprot id: A0A5F4VXT5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:WT1
gene id: 9483:WT1
uniprot id: F7IS25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9483:GDE1
gene id: 9483:GDE1
uniprot id: F7I4Y1
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9483:RNASE9
gene id: 9483:RNASE9
uniprot id: W0UTE4
names: Function
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.
messages: Does not exhibit any ribonuclease activity.

9483:SAP130
gene id: 9483:SAP130
uniprot id: A0A8I3WIR2
uniprot id: F7E211
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

9483:CCN3
gene id: 9483:CCN3
uniprot id: F7HZ48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:MAN1C1
gene id: 9483:MAN1C1
uniprot id: U3F836
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9483:ZSCAN29
gene id: 9483:ZSCAN29
uniprot id: F7HSC8
uniprot id: U3DM54
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9483:SEC63
gene id: 9483:SEC63
uniprot id: A0A8I3WE90
uniprot id: B0KWH2
names: Subcellular Location Annotation
messages: Membrane

9483:ACYP1
gene id: 9483:ACYP1
uniprot id: F7IL81
names: Similarity
messages: Belongs to the acylphosphatase family.

9483:CD4
gene id: 9483:CD4
uniprot id: Q8HZT8
names: Subcellular Location Annotation
messages: Cell membrane

9483:ADK
gene id: 9483:ADK
uniprot id: F6W4L8
uniprot id: F7ITC7
uniprot id: U3E4R2
uniprot id: U3FJH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9483:FADS3
gene id: 9483:FADS3
uniprot id: U3B9H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Endoplasmic reticulum membrane

9483:LOC100389386
gene id: 9483:LOC100389386
uniprot id: A0A2R8MD06
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:NHP2
gene id: 9483:NHP2
uniprot id: A0A2R8MXQ1
uniprot id: F7ISE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9483:ELF5
gene id: 9483:ELF5
uniprot id: A0A2R8N438
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:LOC100399888
gene id: 9483:LOC100399888
uniprot id: F7GHA7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CELF3
gene id: 9483:CELF3
uniprot id: F7I228
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9483:TMBIM4
gene id: 9483:TMBIM4
uniprot id: U3DZ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9483:CBFA2T2
gene id: 9483:CBFA2T2
uniprot id: U3C6N7
names: Similarity
messages: Belongs to the CBFA2T family.

9483:JPT2
gene id: 9483:JPT2
uniprot id: U3FN87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9483:URAD
gene id: 9483:URAD
uniprot id: F7GNJ9
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9483:SUSD3
gene id: 9483:SUSD3
uniprot id: A0A2R8M4Z9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:DOLK
gene id: 9483:DOLK
uniprot id: B0KWE4
names: Similarity
messages: Belongs to the polyprenol kinase family.

9483:FSCN1
gene id: 9483:FSCN1
uniprot id: U3EU72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9483:SMAD3
gene id: 9483:SMAD3
uniprot id: U3DU44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9483:ENTPD4
gene id: 9483:ENTPD4
uniprot id: A0A8J8XFF4
uniprot id: F6YYY9
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9483:GKAP1
gene id: 9483:GKAP1
uniprot id: U3CG34
names: Similarity
messages: Belongs to the GKAP1 family.

9483:MED18
gene id: 9483:MED18
uniprot id: F7HVT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:EDEM3
gene id: 9483:EDEM3
uniprot id: A0A5K1UHZ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9483:HCFC2
gene id: 9483:HCFC2
uniprot id: F7HUQ6
names: Subcellular Location Annotation
messages: Nucleus

9483:ERLIN2
gene id: 9483:ERLIN2
uniprot id: U3DBC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9483:NUBP2
gene id: 9483:NUBP2
uniprot id: U3DZG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9483:SLC7A9
gene id: 9483:SLC7A9
uniprot id: F6X914
names: Subcellular Location Annotation
messages: Membrane

9483:AMOTL2
gene id: 9483:AMOTL2
uniprot id: U3E3V5
names: Similarity
messages: Belongs to the angiomotin family.

9483:LGALSL
gene id: 9483:LGALSL
uniprot id: U3AUG4
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.

9483:MOB1A
gene id: 9483:MOB1A
uniprot id: F7H5V9
names: Similarity
messages: Belongs to the MOB1/phocein family.

9483:PSMA2
gene id: 9483:PSMA2
uniprot id: F7IE60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:ACTR2
gene id: 9483:ACTR2
uniprot id: F7EI23
uniprot id: U3EIC6
names: Similarity
messages: Belongs to the actin family.

9483:KMO
gene id: 9483:KMO
uniprot id: F7HY38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

9483:PYY
gene id: 9483:PYY
uniprot id: F6RMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9483:WNT16
gene id: 9483:WNT16
uniprot id: A0A5F4WIZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:ATAD2B
gene id: 9483:ATAD2B
uniprot id: F7I4W1
names: Similarity
messages: Belongs to the AAA ATPase family.

9483:UBLCP1
gene id: 9483:UBLCP1
uniprot id: U3FI55
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

9483:ALDOB
gene id: 9483:ALDOB
uniprot id: F6RI00
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9483:NAPA
gene id: 9483:NAPA
uniprot id: U3EUR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9483:CA10
gene id: 9483:CA10
uniprot id: F7GIT9
uniprot id: U3D656
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9483:NMNAT1
gene id: 9483:NMNAT1
uniprot id: U3CM79
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9483:LRP5
gene id: 9483:LRP5
uniprot id: U3D8R2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:MCOLN3
gene id: 9483:MCOLN3
uniprot id: F6RG56
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily.
messages: Channel activity is activated by PtdIns(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) (PubMed:29019979). Inhibited by lumenal H(+) and Na(+). The channel pore shows dynamic behavior and undergoes spontaneous, Ca(2+)-dependent modulation when conducting Ca(2+).
messages: Early endosome membrane
messages: Homotetramer (PubMed:29019979). Can heterooligomerize with MCOLN1; heteromeric assemblies have different channel properties as compared to the respective homooligomers and may be tissue-specific. May heterooligomerize with TRPV5 to form a functional distinct ion channel (By similarity). Interacts with GABARAPL2 (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: N-glycosylated.
messages: Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events (PubMed:29019979). Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (By similarity). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity).
messages: The most N-terminal extracellular/lumenal domain (referred to as I-II linker or polycystin-mucolipin domain) contributes to a structure with a four-fold rotational symmetry in a tetrameric assembly; the structure contains a central highly electronegative pore with a 14 A diameter. The pore is critical for Ca(2+) and pH regulation. The protruding structure formed by the I-II linkers may contain all the interaction sites with lipids and proteins in the endolysosomal lumen.
messages: autophagosome membrane
messages: stereocilium membrane

9483:HENMT1
gene id: 9483:HENMT1
uniprot id: U3DYW0
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

9483:IDE
gene id: 9483:IDE
uniprot id: F7GU26
names: Similarity
messages: Belongs to the peptidase M16 family.

9483:LOC100406481
gene id: 9483:LOC100406481
uniprot id: F7CVP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9483:YPEL4
gene id: 9483:YPEL4
uniprot id: F7CLM8
names: Similarity
messages: Belongs to the yippee family.

9483:TRIP12
gene id: 9483:TRIP12
uniprot id: A0A8J8XHJ3
uniprot id: F7EIN3
uniprot id: U3EA63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9483:TRRAP
gene id: 9483:TRRAP
uniprot id: F7HRK8
uniprot id: F7HRL8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.

9483:ALG8
gene id: 9483:ALG8
uniprot id: F7FEU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:POP7
gene id: 9483:POP7
uniprot id: F7DTG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

9483:DDB1
gene id: 9483:DDB1
uniprot id: F7GX55
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9483:CD53
gene id: 9483:CD53
uniprot id: A0A8I3WAT5
uniprot id: F7HHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:TMEM9B
gene id: 9483:TMEM9B
uniprot id: F6RAC2
names: Similarity
messages: Belongs to the TMEM9 family.

9483:TM4SF1
gene id: 9483:TM4SF1
uniprot id: F6S9T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9483:CARNMT1
gene id: 9483:CARNMT1
uniprot id: F6VKA5
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

9483:EPHA10
gene id: 9483:EPHA10
uniprot id: U3E2Z3
names: Subcellular Location Annotation
messages: Membrane

9483:ADCY4
gene id: 9483:ADCY4
uniprot id: F7GTG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9483:TBC1D7
gene id: 9483:TBC1D7
uniprot id: A0A2R8M8P0
uniprot id: F6PP80
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9483:PYCR2
gene id: 9483:PYCR2
uniprot id: L7N0W5
uniprot id: U3CV44
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9483:ATF7IP
gene id: 9483:ATF7IP
uniprot id: F7ILH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9483:LOC100408534
gene id: 9483:LOC100408534
uniprot id: H9KYE5
names: Similarity
messages: Belongs to the MISS family.

9483:NAA10
gene id: 9483:NAA10
uniprot id: B0KWW1
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9483:SLF2
gene id: 9483:SLF2
uniprot id: U3D0T8
names: Similarity
messages: Belongs to the FAM178 family.

9483:C11H11orf87
gene id: 9483:C11H11orf87
uniprot id: F7GQ18
names: Subcellular Location Annotation
messages: Membrane

9483:MYOD1
gene id: 9483:MYOD1
uniprot id: U3FGJ7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9483:RNF7
gene id: 9483:RNF7
uniprot id: F7EDD9
names: Similarity
messages: Belongs to the RING-box family.

9483:TNFSF11
gene id: 9483:TNFSF11
uniprot id: A0A0U5JXT4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9483:FUNDC1
gene id: 9483:FUNDC1
uniprot id: A0A2R8P7B2
uniprot id: U3DRL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

9483:TLE1
gene id: 9483:TLE1
uniprot id: A0A2R8MPJ5
uniprot id: A0A2R8N1C0
uniprot id: U3D0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9483:ABCD2
gene id: 9483:ABCD2
uniprot id: A0A8I3WI60
uniprot id: F6SKS4
names: Function
names: Subunit
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:CLIC4
gene id: 9483:CLIC4
uniprot id: F7EXF2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9483:KCTD13
gene id: 9483:KCTD13
uniprot id: U3DBP3
names: Similarity
messages: Belongs to the BACURD family.

9483:IRF1
gene id: 9483:IRF1
uniprot id: B0KWP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:SCGB1A1
gene id: 9483:SCGB1A1
uniprot id: F7I6D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

9483:STK3
gene id: 9483:STK3
uniprot id: A0A2R8M5U3
uniprot id: U3DWY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9483:HLX
gene id: 9483:HLX
uniprot id: F7IQA7
names: Subcellular Location Annotation
messages: Nucleus

9483:HEXIM1
gene id: 9483:HEXIM1
uniprot id: F7F2K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9483:SNAP25
gene id: 9483:SNAP25
uniprot id: F7GP26
uniprot id: U3DAS2
uniprot id: U3DKT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: perinuclear region
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9483:TBRG1
gene id: 9483:TBRG1
uniprot id: U3F8Y8
names: Subcellular Location Annotation
messages: Nucleus

9483:CS
gene id: 9483:CS
uniprot id: F7F4A4
uniprot id: U3B7T8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Homodimer.
messages: Mitochondrion matrix

9483:CDH7
gene id: 9483:CDH7
uniprot id: A0A8I4A4H3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:MYO1D
gene id: 9483:MYO1D
uniprot id: F7IG85
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:TRAF3
gene id: 9483:TRAF3
uniprot id: F7B686
uniprot id: F7IEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9483:FXN
gene id: 9483:FXN
uniprot id: F7G7D3
names: Similarity
messages: Belongs to the frataxin family.

9483:CCNT2
gene id: 9483:CCNT2
uniprot id: F6PJF3
uniprot id: F6TT41
names: Similarity
messages: Belongs to the cyclin family.

9483:SLC25A1
gene id: 9483:SLC25A1
uniprot id: U3EX65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:RAB32
gene id: 9483:RAB32
uniprot id: F6YNF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9483:RRM1
gene id: 9483:RRM1
uniprot id: F6ZKF5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9483:LHX3
gene id: 9483:LHX3
uniprot id: A0A2R8MDX0
uniprot id: F6XKK4
names: Subcellular Location Annotation
messages: Nucleus

9483:FAM126A
gene id: 9483:FAM126A
uniprot id: U3CVR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9483:GCK
gene id: 9483:GCK
uniprot id: A0A8I4A2C9
uniprot id: U3CPV2
names: Similarity
messages: Belongs to the hexokinase family.

9483:ZMYND10
gene id: 9483:ZMYND10
uniprot id: F7GCB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

9483:S100A10
gene id: 9483:S100A10
uniprot id: F7FGI3
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9483:ZFYVE27
gene id: 9483:ZFYVE27
uniprot id: F6Y1V3
uniprot id: F6ZM63
uniprot id: F7EBU4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

9483:APITD1
gene id: 9483:APITD1
uniprot id: A0A2R8MH83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Nucleus
messages: kinetochore

9483:VBP1
gene id: 9483:VBP1
uniprot id: B0KWU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9483:CDKL1
gene id: 9483:CDKL1
uniprot id: F7GM77
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:MYO10
gene id: 9483:MYO10
uniprot id: A0A8I4A4S3
uniprot id: F7AAV3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:PCBD1
gene id: 9483:PCBD1
uniprot id: A0A2R8MHV7
uniprot id: F7GPT5
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9483:DLX2
gene id: 9483:DLX2
uniprot id: F6WHW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9483:DNAJA1
gene id: 9483:DNAJA1
uniprot id: F7I6Q8
names: Subcellular Location Annotation
messages: Membrane

9483:NPHS2
gene id: 9483:NPHS2
uniprot id: F7G7A4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9483:ATP8
gene id: 9483:ATP8
uniprot id: A0A0U1XIX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9483:NR1I3
gene id: 9483:NR1I3
uniprot id: A0A2R8NDY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:THAP1
gene id: 9483:THAP1
uniprot id: F7F581
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9483:LOC100388540
gene id: 9483:LOC100388540
uniprot id: U3ECM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9483:LOC100399827
gene id: 9483:LOC100399827
uniprot id: F7DH04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TMC7
gene id: 9483:TMC7
uniprot id: F6XXI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9483:LOC100409993
gene id: 9483:LOC100409993
uniprot id: A0A8I3X651
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:MYO16
gene id: 9483:MYO16
uniprot id: F7ISV5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:TMEM54
gene id: 9483:TMEM54
uniprot id: F7BVY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9483:IZUMO2
gene id: 9483:IZUMO2
uniprot id: F6Y8E8
names: Similarity
messages: Belongs to the Izumo family.

9483:XCR1
gene id: 9483:XCR1
uniprot id: F7HJW0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:USP16
gene id: 9483:USP16
uniprot id: F7GMW6
uniprot id: F7H4I8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9483:LOC100394518
gene id: 9483:LOC100394518
uniprot id: F6SKV2
names: Similarity
messages: Belongs to the intermediate filament family.

9483:PBX2
gene id: 9483:PBX2
uniprot id: U3BXR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9483:COQ5
gene id: 9483:COQ5
uniprot id: U3FTS7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9483:EHD3
gene id: 9483:EHD3
uniprot id: F7IEJ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9483:TCP11L2
gene id: 9483:TCP11L2
uniprot id: A0A2R8MUW6
names: Similarity
messages: Belongs to the TCP11 family.

9483:SLC5A11
gene id: 9483:SLC5A11
uniprot id: F7IQQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9483:SMC2
gene id: 9483:SMC2
uniprot id: U3BGS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

9483:EIF3J
gene id: 9483:EIF3J
uniprot id: F7A6T5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9483:NEFL
gene id: 9483:NEFL
uniprot id: F6UX82
uniprot id: F6VHK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: cytoskeleton

9483:AFF1
gene id: 9483:AFF1
uniprot id: U3E6U6
uniprot id: U3FG32
names: Similarity
messages: Belongs to the AF4 family.

9483:GAD1
gene id: 9483:GAD1
uniprot id: U3DTP3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9483:ACLY
gene id: 9483:ACLY
uniprot id: F7DBY4
uniprot id: F7DSU4
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9483:ASB13
gene id: 9483:ASB13
uniprot id: U3ENW7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:PPP2R2C
gene id: 9483:PPP2R2C
uniprot id: A0A2R8MBU1
uniprot id: F7HRR7
uniprot id: F7HVT4
uniprot id: U3EWR4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9483:SLC16A6
gene id: 9483:SLC16A6
uniprot id: F7G1I2
uniprot id: U3E6Q4
names: Subcellular Location Annotation
messages: Membrane

9483:TAF7
gene id: 9483:TAF7
uniprot id: F6SLI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9483:TOP2B
gene id: 9483:TOP2B
uniprot id: F6S771
uniprot id: U3BD56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9483:PDE6H
gene id: 9483:PDE6H
uniprot id: A0A2R8N3S8
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9483:SLC4A8
gene id: 9483:SLC4A8
uniprot id: F7EQL8
uniprot id: F7EQN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9483:ARHGDIB
gene id: 9483:ARHGDIB
uniprot id: F7INT7
names: Similarity
messages: Belongs to the Rho GDI family.

9483:LOC100414863
gene id: 9483:LOC100414863
uniprot id: F7FBY9
names: Similarity
messages: Belongs to the GAGE family.

9483:PPM1G
gene id: 9483:PPM1G
uniprot id: F7BFT9
names: Similarity
messages: Belongs to the PP2C family.

9483:TMEM91
gene id: 9483:TMEM91
uniprot id: U3FK42
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9483:RORA
gene id: 9483:RORA
uniprot id: U3FGL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:MRPL11
gene id: 9483:MRPL11
uniprot id: F7I4I1
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

9483:JAGN1
gene id: 9483:JAGN1
uniprot id: F7HKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:NEO1
gene id: 9483:NEO1
uniprot id: A0A8I3WAW4
uniprot id: A0A8J8XLN2
uniprot id: A0A8J8Y231
uniprot id: A0A8J8Y270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9483:LMX1A
gene id: 9483:LMX1A
uniprot id: A0A8I4A505
names: Subcellular Location Annotation
messages: Nucleus

9483:MECP2
gene id: 9483:MECP2
uniprot id: F7I9A5
names: Function
names: Subcellular Location Annotation
messages: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
messages: Nucleus

9483:NIBAN2
gene id: 9483:NIBAN2
uniprot id: U3CBV4
names: Similarity
messages: Belongs to the Niban family.

9483:PPP3CA
gene id: 9483:PPP3CA
uniprot id: U3B0P1
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9483:PURG
gene id: 9483:PURG
uniprot id: F7HUQ5
uniprot id: U3DI37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9483:E2F2
gene id: 9483:E2F2
uniprot id: F7IIE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9483:BTG2
gene id: 9483:BTG2
uniprot id: F7H971
names: Similarity
messages: Belongs to the BTG family.

9483:SLC29A3
gene id: 9483:SLC29A3
uniprot id: F6ZJ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9483:SERPINA6
gene id: 9483:SERPINA6
uniprot id: F7IEE1
names: Similarity
messages: Belongs to the serpin family.

9483:RPL21
gene id: 9483:RPL21
uniprot id: A0A2R8MC53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9483:LOC103796642
gene id: 9483:LOC103796642
uniprot id: A0A5F4VU17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9483:SLC35E4
gene id: 9483:SLC35E4
uniprot id: F6TN73
uniprot id: U3ETL4
names: Subcellular Location Annotation
messages: Membrane

9483:GTF2A1L
gene id: 9483:GTF2A1L
uniprot id: F6WXK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9483:CLCN3
gene id: 9483:CLCN3
uniprot id: U3EFY2
uniprot id: U3EGL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9483:NSDHL
gene id: 9483:NSDHL
uniprot id: U3D149
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9483:HTT
gene id: 9483:HTT
uniprot id: B7XBM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

9483:SNCG
gene id: 9483:SNCG
uniprot id: F6U4X0
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9483:TEC
gene id: 9483:TEC
uniprot id: F7IDK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9483:MAU2
gene id: 9483:MAU2
uniprot id: U3DDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

9483:HACD2
gene id: 9483:HACD2
uniprot id: U3EI14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:BRPF1
gene id: 9483:BRPF1
uniprot id: F7HVR4
uniprot id: U3DCL6
uniprot id: U3E149
names: Subcellular Location Annotation
messages: Nucleus

9483:TRAPPC6A
gene id: 9483:TRAPPC6A
uniprot id: U3EM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9483:TAF1D
gene id: 9483:TAF1D
uniprot id: U3DRE0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9483:MSL3
gene id: 9483:MSL3
uniprot id: U3E4R0
names: Subcellular Location Annotation
messages: Nucleus

9483:PTGR1
gene id: 9483:PTGR1
uniprot id: F7FJC4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9483:ESX1
gene id: 9483:ESX1
uniprot id: F7GUU9
names: Subcellular Location Annotation
messages: Nucleus

9483:GALNT5
gene id: 9483:GALNT5
uniprot id: A0A5F4WAB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:TGM7
gene id: 9483:TGM7
uniprot id: F7ICD6
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9483:TFPI
gene id: 9483:TFPI
uniprot id: U3E227
names: Subcellular Location Annotation
messages: Secreted

9483:PIEZO1
gene id: 9483:PIEZO1
uniprot id: F7IK05
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIEZO (TC 1.A.75) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:STT3B
gene id: 9483:STT3B
uniprot id: U3DLE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9483:PDCD10
gene id: 9483:PDCD10
uniprot id: F7I396
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9483:ARL6IP5
gene id: 9483:ARL6IP5
uniprot id: F7G0P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

9483:PLXNA4
gene id: 9483:PLXNA4
uniprot id: F7FA43
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:GLIPR1
gene id: 9483:GLIPR1
uniprot id: F7IL97
uniprot id: U3CWN0
names: Similarity
messages: Belongs to the CRISP family.

9483:LOC100398638
gene id: 9483:LOC100398638
uniprot id: F7F3A7
names: Similarity
messages: Belongs to the PRR20 family.

9483:TCTN2
gene id: 9483:TCTN2
uniprot id: U3CJ43
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9483:CDKN1B
gene id: 9483:CDKN1B
uniprot id: F7HH57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9483:SPAG7
gene id: 9483:SPAG7
uniprot id: F7I1A9
names: Subcellular Location Annotation
messages: Nucleus

9483:TBR1
gene id: 9483:TBR1
uniprot id: A0A8I3W3Z3
uniprot id: F6UNF8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:PTX3
gene id: 9483:PTX3
uniprot id: U3FG41
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:AP2S1
gene id: 9483:AP2S1
uniprot id: U3CLA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

9483:CD3D
gene id: 9483:CD3D
uniprot id: F7FPX1
names: Subcellular Location Annotation
messages: Membrane

9483:MSMP
gene id: 9483:MSMP
uniprot id: F7F4L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9483:GTF2H5
gene id: 9483:GTF2H5
uniprot id: F7HBD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

9483:CDK5RAP2
gene id: 9483:CDK5RAP2
uniprot id: F6ZC98
names: Subcellular Location Annotation
messages: centrosome

9483:LOC100404252
gene id: 9483:LOC100404252
uniprot id: A0A8I3WDW9
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9483:CCR7
gene id: 9483:CCR7
uniprot id: A0A8I3W856
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:MYF6
gene id: 9483:MYF6
uniprot id: A0A8I3X9W2
names: Subcellular Location Annotation
messages: Nucleus

9483:PAGE4
gene id: 9483:PAGE4
uniprot id: U3CV35
names: Similarity
messages: Belongs to the GAGE family.

9483:ECHDC2
gene id: 9483:ECHDC2
uniprot id: F6Z954
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9483:SYNJ1
gene id: 9483:SYNJ1
uniprot id: B0VXG0
uniprot id: F6XBI3
uniprot id: F7GAV4
uniprot id: F7HSJ4
uniprot id: F7IRU2
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9483:POLR1A
gene id: 9483:POLR1A
uniprot id: F7H346
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9483:NAP1L1
gene id: 9483:NAP1L1
uniprot id: A0A5F4WE21
uniprot id: F7AXP6
uniprot id: F7I796
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:FFAR2
gene id: 9483:FFAR2
uniprot id: A0A2R8MC38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:IL2RA
gene id: 9483:IL2RA
uniprot id: Q19LH5
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9483:APOE
gene id: 9483:APOE
uniprot id: U3FTG7
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9483:LMCD1
gene id: 9483:LMCD1
uniprot id: A0A8I3WRW8
uniprot id: U3C7A7
names: Function
names: Subunit
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.

9483:GDF1
gene id: 9483:GDF1
uniprot id: F7GST7
names: Subcellular Location Annotation
messages: Membrane

9483:RDH8
gene id: 9483:RDH8
uniprot id: F7IKQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

9483:CLCN4
gene id: 9483:CLCN4
uniprot id: U3BD79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9483:SERPINB2
gene id: 9483:SERPINB2
uniprot id: B0CMA9
names: Similarity
messages: Belongs to the serpin family.

9483:LGI1
gene id: 9483:LGI1
uniprot id: A0A2R8MNW8
uniprot id: F7A305
names: Subcellular Location Annotation
messages: Secreted

9483:OAZ2
gene id: 9483:OAZ2
uniprot id: F7EVF6
names: Similarity
messages: Belongs to the ODC antizyme family.

9483:DBNDD1
gene id: 9483:DBNDD1
uniprot id: U3ELM4
names: Similarity
messages: Belongs to the dysbindin family.

9483:HIF3A
gene id: 9483:HIF3A
uniprot id: F6X136
names: Subcellular Location Annotation
messages: Nucleus speckle

9483:NDST2
gene id: 9483:NDST2
uniprot id: U3CFR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9483:IL6R
gene id: 9483:IL6R
uniprot id: Q0PIT5
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9483:ATP5PO
gene id: 9483:ATP5PO
uniprot id: B0VXH3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3 (By similarity).
messages: Belongs to the ATPase delta chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

9483:NDUFAF4
gene id: 9483:NDUFAF4
uniprot id: F7IGP2
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9483:ADRA1B
gene id: 9483:ADRA1B
uniprot id: F7IQ78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

9483:SLITRK2
gene id: 9483:SLITRK2
uniprot id: F7IN27
names: Similarity
messages: Belongs to the SLITRK family.

9483:RPL8
gene id: 9483:RPL8
uniprot id: F7GNR1
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9483:AMER1
gene id: 9483:AMER1
uniprot id: F7GVN4
names: Similarity
messages: Belongs to the Amer family.

9483:RETREG1
gene id: 9483:RETREG1
uniprot id: F7ECF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9483:PLK4
gene id: 9483:PLK4
uniprot id: F7E1H1
uniprot id: U3D9B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: centriole

9483:FAM151B
gene id: 9483:FAM151B
uniprot id: F7GXZ1
names: Similarity
messages: Belongs to the FAM151 family.

9483:AK2
gene id: 9483:AK2
uniprot id: U3BWM8
uniprot id: U3DKZ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9483:ENTPD5
gene id: 9483:ENTPD5
uniprot id: U3DZQ7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9483:PHKA1
gene id: 9483:PHKA1
uniprot id: F6WY41
uniprot id: F7I8J7
uniprot id: U3EGD5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

9483:DUSP5
gene id: 9483:DUSP5
uniprot id: F7I5X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9483:SLC39A5
gene id: 9483:SLC39A5
uniprot id: F6U6H4
names: Subcellular Location Annotation
messages: Membrane

9483:BASP1
gene id: 9483:BASP1
uniprot id: F6PRD3
names: Similarity
messages: Belongs to the BASP1 family.

9483:CTBP2
gene id: 9483:CTBP2
uniprot id: F7I3J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9483:SUCLG1
gene id: 9483:SUCLG1
uniprot id: U3BBP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9483:MEF2A
gene id: 9483:MEF2A
uniprot id: F7HSJ6
uniprot id: U3DEP8
uniprot id: U3EXX2
uniprot id: U3F6J9
names: Subcellular Location Annotation
messages: Nucleus

9483:FGD6
gene id: 9483:FGD6
uniprot id: U3DL37
names: Subcellular Location Annotation
messages: cytoskeleton

9483:AP3M1
gene id: 9483:AP3M1
uniprot id: A0A8J8XHJ4
uniprot id: U3FCJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9483:ITPR1
gene id: 9483:ITPR1
uniprot id: U3BP99
uniprot id: U3DVU8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9483:VWC2
gene id: 9483:VWC2
uniprot id: F7CDJ2
names: Subcellular Location Annotation
messages: Synapse

9483:MAN1A1
gene id: 9483:MAN1A1
uniprot id: F6QEE1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9483:TRIM67
gene id: 9483:TRIM67
uniprot id: F6XNZ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Nucleus
messages: cytoskeleton

9483:CDYL2
gene id: 9483:CDYL2
uniprot id: U3DBK7
names: Subcellular Location Annotation
messages: Nucleus

9483:MARCHF4
gene id: 9483:MARCHF4
uniprot id: U3DXK9
names: Subcellular Location Annotation
messages: Membrane

9483:GNB2
gene id: 9483:GNB2
uniprot id: U3F085
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9483:PXMP4
gene id: 9483:PXMP4
uniprot id: A0A8I3X939
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9483:CD2
gene id: 9483:CD2
uniprot id: A5HJL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:VAMP2
gene id: 9483:VAMP2
uniprot id: A0A2R8P2U1
uniprot id: F7IDU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane

9483:LOC100409675
gene id: 9483:LOC100409675
uniprot id: A0A8I4A3H8
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9483:CHRNA10
gene id: 9483:CHRNA10
uniprot id: F6UH81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:MEIS3
gene id: 9483:MEIS3
uniprot id: F6T789
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9483:TLR2
gene id: 9483:TLR2
uniprot id: F7HQL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane
messages: Membrane raft
messages: phagosome membrane

9483:TNNT2
gene id: 9483:TNNT2
uniprot id: F7CP81
uniprot id: F7CPB9
uniprot id: F7HC37
uniprot id: F7HC43
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9483:FGFR1
gene id: 9483:FGFR1
uniprot id: F6W904
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9483:CERCAM
gene id: 9483:CERCAM
uniprot id: F6UXA1
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9483:HPS3
gene id: 9483:HPS3
uniprot id: U3E815
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

9483:TPST1
gene id: 9483:TPST1
uniprot id: F6PPZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9483:RAD9B
gene id: 9483:RAD9B
uniprot id: F7HM50
names: Similarity
messages: Belongs to the rad9 family.

9483:ACAA2
gene id: 9483:ACAA2
uniprot id: U3FQH9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9483:ITGA3
gene id: 9483:ITGA3
uniprot id: F6S164
uniprot id: F7GGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9483:KDM3A
gene id: 9483:KDM3A
uniprot id: F7D9W0
names: Subcellular Location Annotation
messages: Nucleus

9483:ASB18
gene id: 9483:ASB18
uniprot id: F6ZSL7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:PDGFD
gene id: 9483:PDGFD
uniprot id: U3EU18
uniprot id: U3FRK3
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ETF1
gene id: 9483:ETF1
uniprot id: U3FM72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9483:AP3M2
gene id: 9483:AP3M2
uniprot id: F7DPW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9483:SPSB3
gene id: 9483:SPSB3
uniprot id: F7CWP3
uniprot id: U3D6A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Belongs to the TRIM/RBCC family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Nucleus

9483:HBM
gene id: 9483:HBM
uniprot id: B0VX77
names: Similarity
messages: Belongs to the globin family.

9483:CNTNAP4
gene id: 9483:CNTNAP4
uniprot id: U3FWU7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SNRPG
gene id: 9483:SNRPG
uniprot id: A0A2R8MK56
uniprot id: U3EIA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9483:PFKFB2
gene id: 9483:PFKFB2
uniprot id: A0A8I3X071
uniprot id: F6UMW6
uniprot id: F6VUU1
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9483:ENAH
gene id: 9483:ENAH
uniprot id: U3D144
uniprot id: U3FF40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

9483:SLC6A4
gene id: 9483:SLC6A4
uniprot id: F7BZJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

9483:RAE1
gene id: 9483:RAE1
uniprot id: F7EGR4
uniprot id: U3DVX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: spindle pole

9483:RAB29
gene id: 9483:RAB29
uniprot id: F7E162
uniprot id: U3F4Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9483:TMED1
gene id: 9483:TMED1
uniprot id: F7D6C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9483:TAF10
gene id: 9483:TAF10
uniprot id: F7AXR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

9483:LOC108589472
gene id: 9483:LOC108589472
uniprot id: B0VXF6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:FLOT2
gene id: 9483:FLOT2
uniprot id: F7E667
uniprot id: U3CGZ2
uniprot id: U3FTR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9483:PFDN1
gene id: 9483:PFDN1
uniprot id: F6WRG6
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9483:RABGGTA
gene id: 9483:RABGGTA
uniprot id: F7FA20
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

9483:LOC100405623
gene id: 9483:LOC100405623
uniprot id: F7I0C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space

9483:TM4SF4
gene id: 9483:TM4SF4
uniprot id: A0A8I4A5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9483:CAPZA1
gene id: 9483:CAPZA1
uniprot id: A0A2R8MC54
uniprot id: F6QUE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9483:APH1A
gene id: 9483:APH1A
uniprot id: U3DJW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9483:RGR
gene id: 9483:RGR
uniprot id: U3CHN1
names: Subcellular Location Annotation
messages: Membrane

9483:DDA1
gene id: 9483:DDA1
uniprot id: A0A8I3WNF3
names: Similarity
messages: Belongs to the DDA1 family.

9483:PRKG2
gene id: 9483:PRKG2
uniprot id: F7GKY2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9483:CCT5
gene id: 9483:CCT5
uniprot id: F6Y1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:FBXO25
gene id: 9483:FBXO25
uniprot id: U3C1A7
uniprot id: U3DQD2
names: Subcellular Location Annotation
messages: Nucleus

9483:ATG13
gene id: 9483:ATG13
uniprot id: F6SY16
uniprot id: F6YCQ9
uniprot id: U3CX99
uniprot id: U3DRN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9483:DYNC1I1
gene id: 9483:DYNC1I1
uniprot id: F6S1D1
uniprot id: F6SCA4
uniprot id: U3CMA6
uniprot id: U3D6B8
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9483:SMARCB1
gene id: 9483:SMARCB1
uniprot id: U3DYG0
uniprot id: U3FFQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

9483:CSE1L
gene id: 9483:CSE1L
uniprot id: F6Y7A9
uniprot id: F7BAH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9483:NPY2R
gene id: 9483:NPY2R
uniprot id: F7HQL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100412636
gene id: 9483:LOC100412636
uniprot id: A0A5F4WMT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SEMA4D
gene id: 9483:SEMA4D
uniprot id: U3EQJ2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:COPB2
gene id: 9483:COPB2
uniprot id: F6YR44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

9483:UBE2D3
gene id: 9483:UBE2D3
uniprot id: A0A2R8PG33
uniprot id: F6Z536
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:MMACHC
gene id: 9483:MMACHC
uniprot id: U3E275
names: Similarity
messages: Belongs to the MMACHC family.

9483:PXN
gene id: 9483:PXN
uniprot id: U3DPY9
uniprot id: U3FKI2
names: Subcellular Location Annotation
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

9483:UBE3D
gene id: 9483:UBE3D
uniprot id: U3FPY6
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

9483:SYNGR2
gene id: 9483:SYNGR2
uniprot id: F7H8R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9483:PKP1
gene id: 9483:PKP1
uniprot id: U3FXY0
names: Similarity
messages: Belongs to the beta-catenin family.

9483:BLOC1S6
gene id: 9483:BLOC1S6
uniprot id: A0A2R8MPZ9
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9483:PSMD8
gene id: 9483:PSMD8
uniprot id: U3DPY5
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9483:DDIT4
gene id: 9483:DDIT4
uniprot id: F6X5P2
names: Similarity
messages: Belongs to the DDIT4 family.

9483:EIF3L
gene id: 9483:EIF3L
uniprot id: U3FPU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9483:TMSB15A
gene id: 9483:TMSB15A
uniprot id: F7ILT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9483:LOC103795964
gene id: 9483:LOC103795964
uniprot id: U3DJ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

9483:TAS2R40
gene id: 9483:TAS2R40
uniprot id: F7I729
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9483:HSD17B13
gene id: 9483:HSD17B13
uniprot id: F7IKL6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:STX18
gene id: 9483:STX18
uniprot id: U3DZT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9483:LOC100386966
gene id: 9483:LOC100386966
uniprot id: F6YHG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9483:TRDMT1
gene id: 9483:TRDMT1
uniprot id: F6URL6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9483:ATP13A3
gene id: 9483:ATP13A3
uniprot id: A0A2R8P9L5
uniprot id: A0A5F4VU76
uniprot id: A0A5F4WFZ4
uniprot id: A0A5F4WME6
uniprot id: U3FVG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9483:RPS27A
gene id: 9483:RPS27A
uniprot id: A0A2R8MVQ0
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9483:WIF1
gene id: 9483:WIF1
uniprot id: U3D640
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:IREB2
gene id: 9483:IREB2
uniprot id: F6T5R8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

9483:ATG12
gene id: 9483:ATG12
uniprot id: U3ER96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9483:IMPDH1
gene id: 9483:IMPDH1
uniprot id: F7EBY6
uniprot id: F7EC54
uniprot id: U3FWE8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9483:EFHC1
gene id: 9483:EFHC1
uniprot id: A0A2R8PDG3
names: Subcellular Location Annotation
messages: cilium axoneme

9483:PDK1
gene id: 9483:PDK1
uniprot id: U3FE81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9483:FKRP
gene id: 9483:FKRP
uniprot id: F6TG30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9483:RNASEH2B
gene id: 9483:RNASEH2B
uniprot id: U3ERP0
uniprot id: U3FQM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

9483:NATD1
gene id: 9483:NATD1
uniprot id: H9KXF9
names: Similarity
messages: Belongs to the NATD1 family.

9483:MCM6
gene id: 9483:MCM6
uniprot id: F6R809
uniprot id: U3DPS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9483:AHCY
gene id: 9483:AHCY
uniprot id: F6TZT1
uniprot id: U3ED98
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9483:GIMD1
gene id: 9483:GIMD1
uniprot id: F7IRN2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9483:GNAT1
gene id: 9483:GNAT1
uniprot id: F7I5Q7
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9483:DYNC1LI2
gene id: 9483:DYNC1LI2
uniprot id: U3E101
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9483:LOC100406436
gene id: 9483:LOC100406436
uniprot id: A0A2R8M558
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:HNMT
gene id: 9483:HNMT
uniprot id: A0A2R8MUE3
names: Function
names: Subunit
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

9483:SPIRE2
gene id: 9483:SPIRE2
uniprot id: U3DC82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

9483:ACAD9
gene id: 9483:ACAD9
uniprot id: F7E1K6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9483:GALNT6
gene id: 9483:GALNT6
uniprot id: F6R4R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:SFT2D1
gene id: 9483:SFT2D1
uniprot id: F7IAM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9483:TRNAU1AP
gene id: 9483:TRNAU1AP
uniprot id: F7HVM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9483:GDAP2
gene id: 9483:GDAP2
uniprot id: F7IHW2
names: Similarity
messages: Belongs to the GDAP2 family.

9483:BBS2
gene id: 9483:BBS2
uniprot id: F7IFY6
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9483:TMEM107
gene id: 9483:TMEM107
uniprot id: U3DQS6
names: Subcellular Location Annotation
messages: Membrane

9483:MAGOH
gene id: 9483:MAGOH
uniprot id: F7ID78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

9483:GPBP1
gene id: 9483:GPBP1
uniprot id: A0A2R8MUC8
uniprot id: A0A8J8YDL2
uniprot id: U3BEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9483:DYNLT3
gene id: 9483:DYNLT3
uniprot id: F7HCW6
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9483:TMEM45B
gene id: 9483:TMEM45B
uniprot id: U3D5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9483:YIPF5
gene id: 9483:YIPF5
uniprot id: F7DBS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9483:TERF1
gene id: 9483:TERF1
uniprot id: F7IQX2
uniprot id: F7IQX6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

9483:DERL2
gene id: 9483:DERL2
uniprot id: A0A2R8N704
uniprot id: U3CUW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:PLPP1
gene id: 9483:PLPP1
uniprot id: F7H4T5
uniprot id: F7H4U3
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

9483:C15H3orf70
gene id: 9483:C15H3orf70
uniprot id: U3BN04
names: Similarity
messages: Belongs to the UPF0524 family.

9483:WDFY1
gene id: 9483:WDFY1
uniprot id: F7IMJ5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9483:TOM1L1
gene id: 9483:TOM1L1
uniprot id: F7HB32
names: Similarity
messages: Belongs to the TOM1 family.

9483:GGTA1
gene id: 9483:GGTA1
uniprot id: Q8SQ20
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Golgi stack membrane
messages: Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3) (By similarity).
messages: The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).

9483:MAPK8
gene id: 9483:MAPK8
uniprot id: A0A2R8MUK9
uniprot id: A0A5K1UJA7
uniprot id: F7AK86
uniprot id: U3FKG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9483:A3GALT2
gene id: 9483:A3GALT2
uniprot id: F7I2K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9483:LOC100393374
gene id: 9483:LOC100393374
uniprot id: F7BEV5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9483:HOXB2
gene id: 9483:HOXB2
uniprot id: F6XPS8
names: Subcellular Location Annotation
messages: Nucleus

9483:TMA16
gene id: 9483:TMA16
uniprot id: U3CI81
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

9483:SPON1
gene id: 9483:SPON1
uniprot id: F7G1Q5
names: Subcellular Location Annotation
messages: extracellular matrix

9483:NPEPL1
gene id: 9483:NPEPL1
uniprot id: U3DHS5
names: Similarity
messages: Belongs to the peptidase M17 family.

9483:TMPRSS13
gene id: 9483:TMPRSS13
uniprot id: F7H942
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ZC3HC1
gene id: 9483:ZC3HC1
uniprot id: F6T351
names: Subcellular Location Annotation
messages: Nucleus

9483:MRGPRX1
gene id: 9483:MRGPRX1
uniprot id: F7H5A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ZDHHC6
gene id: 9483:ZDHHC6
uniprot id: A0A5F4VV38
uniprot id: U3CJD2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:CACNG3
gene id: 9483:CACNG3
uniprot id: F7HXI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

9483:ST3GAL6
gene id: 9483:ST3GAL6
uniprot id: F7A7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:FOXI1
gene id: 9483:FOXI1
uniprot id: A0A8I3X8U8
names: Subcellular Location Annotation
messages: Nucleus

9483:POLR2I
gene id: 9483:POLR2I
uniprot id: F7IC64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9483:CENPU
gene id: 9483:CENPU
uniprot id: A0A2R8MGS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

9483:ELOVL3
gene id: 9483:ELOVL3
uniprot id: A0A8I3VZ93
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9483:TBCA
gene id: 9483:TBCA
uniprot id: F7HGE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9483:NELFCD
gene id: 9483:NELFCD
uniprot id: F7HUP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

9483:SMIM18
gene id: 9483:SMIM18
uniprot id: U3FM97
names: Subcellular Location Annotation
messages: Membrane

9483:BCL2L14
gene id: 9483:BCL2L14
uniprot id: A0A8I3W6A9
names: Similarity
messages: Belongs to the Bcl-2 family.

9483:CDCA7L
gene id: 9483:CDCA7L
uniprot id: F7I2C0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:CYTB
gene id: 9483:CYTB
uniprot id: A0A0P0RS16
uniprot id: Q8M5M3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

9483:SH3GL2
gene id: 9483:SH3GL2
uniprot id: F7IB79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9483:DYRK2
gene id: 9483:DYRK2
uniprot id: U3DTS3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9483:LAMTOR3
gene id: 9483:LAMTOR3
uniprot id: F6WBU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9483:SGPL1
gene id: 9483:SGPL1
uniprot id: U3DE76
names: Similarity
messages: Belongs to the group II decarboxylase family.

9483:RRAGA
gene id: 9483:RRAGA
uniprot id: U3FLU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9483:INTS3
gene id: 9483:INTS3
uniprot id: F7FD65
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

9483:CFAP52
gene id: 9483:CFAP52
uniprot id: F7ISM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: cilium axoneme
messages: flagellum

9483:ARPP19
gene id: 9483:ARPP19
uniprot id: F7AF76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

9483:RSBN1
gene id: 9483:RSBN1
uniprot id: F7HUK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9483:RMND1
gene id: 9483:RMND1
uniprot id: A0A8I3WST0
uniprot id: F7FN68
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9483:CXCL8
gene id: 9483:CXCL8
uniprot id: A0A8I4A1B7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

9483:ORAI2
gene id: 9483:ORAI2
uniprot id: U3FX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9483:PSME3
gene id: 9483:PSME3
uniprot id: U3BRR0
names: Similarity
messages: Belongs to the PA28 family.

9483:CYBB
gene id: 9483:CYBB
uniprot id: F7D530
names: Subcellular Location Annotation
messages: Membrane

9483:GLE1
gene id: 9483:GLE1
uniprot id: F7AHA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

9483:HOXA10
gene id: 9483:HOXA10
uniprot id: B0VXK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9483:CA8
gene id: 9483:CA8
uniprot id: F6W8S5
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9483:VPS52
gene id: 9483:VPS52
uniprot id: F7IGV6
names: Similarity
messages: Belongs to the VPS52 family.

9483:HOXB5
gene id: 9483:HOXB5
uniprot id: F6ZUY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:PPP2R2B
gene id: 9483:PPP2R2B
uniprot id: A0A8J8XP81
uniprot id: A0A8J8Y710
uniprot id: F7GGA2
uniprot id: U3D9F9
uniprot id: U3E8G8
uniprot id: U3ETB8
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9483:DPM1
gene id: 9483:DPM1
uniprot id: F6RQC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

9483:ARHGEF12
gene id: 9483:ARHGEF12
uniprot id: A0A5F4VTL2
uniprot id: U3D1J4
uniprot id: U3EDT1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9483:UNC5D
gene id: 9483:UNC5D
uniprot id: A0A2R8MK76
uniprot id: A0A8I3WKF9
uniprot id: F7IHE0
uniprot id: F7IJP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9483:PPIH
gene id: 9483:PPIH
uniprot id: F7IEH5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:LDHAL6B
gene id: 9483:LDHAL6B
uniprot id: A0A5F4W344
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9483:BEST1
gene id: 9483:BEST1
uniprot id: F7I8L3
uniprot id: F7IFS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9483:SEPSECS
gene id: 9483:SEPSECS
uniprot id: F7GM93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9483:SMAD4
gene id: 9483:SMAD4
uniprot id: A0A2R8MAR1
uniprot id: U3E3A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9483:ANXA4
gene id: 9483:ANXA4
uniprot id: U3DQF6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9483:PJVK
gene id: 9483:PJVK
uniprot id: F7IH02
names: Similarity
messages: Belongs to the gasdermin family.

9483:OXT
gene id: 9483:OXT
uniprot id: G0ZNF4
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9483:BMP7
gene id: 9483:BMP7
uniprot id: U3CV29
names: Similarity
messages: Belongs to the TGF-beta family.

9483:GPKOW
gene id: 9483:GPKOW
uniprot id: F6Y066
uniprot id: U3BSQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

9483:NIPAL1
gene id: 9483:NIPAL1
uniprot id: F7I3E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9483:CHST1
gene id: 9483:CHST1
uniprot id: U3FRR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9483:OSBPL2
gene id: 9483:OSBPL2
uniprot id: F7IBR7
uniprot id: F7IE45
uniprot id: U3FU23
names: Similarity
messages: Belongs to the OSBP family.

9483:RPS11
gene id: 9483:RPS11
uniprot id: F7EY42
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9483:GNRHR
gene id: 9483:GNRHR
uniprot id: A0A2R8M762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:GPR158
gene id: 9483:GPR158
uniprot id: F7HR18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9483:LOC100399107
gene id: 9483:LOC100399107
uniprot id: A0A8I3W5H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:THBS1
gene id: 9483:THBS1
uniprot id: F7IIH4
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:STN1
gene id: 9483:STN1
uniprot id: A0A5F4VRA7
uniprot id: F6SF17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

9483:HMGB1
gene id: 9483:HMGB1
uniprot id: B0CM99
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on multiple sites upon stimulation with LPS (By similarity). Acetylation on lysine residues in the nuclear localization signals (NLS 1 and NLS 2) leads to cytoplasmic localization and subsequent secretion. Acetylation on Lys-3 results in preferential binding to DNA ends and impairs DNA bending activity (By similarity).
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Endosome
messages: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers.
messages: HMG box 2 mediates pro-inflammatory cytokine-stimulating activity and binding to TLR4. However, not involved in mediating immunogenic activity in the context of apoptosis-induced immune tolerance.
messages: In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages.
messages: In the extracellular compartment (following either active secretion or passive release) involved in regulation of the inflammatory response. Fully reduced HGMB1 (which subsequently gets oxidized after release) in association with CXCL12 mediates the recruitment of inflammatory cells during the initial phase of tissue injury; the CXCL12:HMGB1 complex triggers CXCR4 homodimerization. Induces the migration of monocyte-derived immature dendritic cells and seems to regulate adhesive and migratory functions of neutrophils implicating AGER/RAGE and ITGAM. Can bind to various types of DNA and RNA including microbial unmethylated CpG-DNA to enhance the innate immune response to nucleic acids. Proposed to act in promiscuous DNA/RNA sensing which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. Promotes extracellular DNA-induced AIM2 inflammasome activation implicating AGER/RAGE. Disulfide HMGB1 binds to transmembrane receptors, such as AGER/RAGE, TLR2, TLR4 and probably TREM1, thus activating their signal transduction pathways. Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10. Promotes secretion of interferon-gamma by macrophage-stimulated natural killer (NK) cells in concert with other cytokines like IL-2 or IL-12. TLR4 is proposed to be the primary receptor promoting macrophage activation and signaling through TLR4 seems to implicate LY96/MD-2. In bacterial LPS- or LTA-mediated inflammatory responses binds to the endotoxins and transfers them to CD14 for signaling to the respective TLR4:LY96 and TLR2 complexes. Contributes to tumor proliferation by association with ACER/RAGE. Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex. Binding to class A CpG activates cytokine production in plasmacytoid dendritic cells implicating TLR9, MYD88 and AGER/RAGE and can activate autoreactive B cells. Via HMGB1-containing chromatin immune complexes may also promote B c…
messages: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance. Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and pro-inflammatory activities (By similarity).
messages: Interacts (fully reduced HMGB1) with CXCL12; probably in a 1:2 ratio involving two molecules of CXCL12, each interacting with one HMG box of HMGB1; inhibited by glycyrrhizin. Associates with the TLR4:LY96 receptor complex. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Interacts (in cytoplasm upon starvation) with BECN1; inhibits the interaction of BECN1 and BCL2 leading to promotion of autophagy. Interacts with KPNA1; involved in nuclear import. Interacts with SREBF1, TLR2, TLR4, TLR9, PTPRZ1, APEX1, FEN1, POLB, TERT. Interacts with IL1B, AGER, MSH2, XPA, XPC, HNF1A, TP53. Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with THBD; prevents HGMB1 interaction with ACER/RAGE and inhibits HGMB1 pro-inflammatory activity. Interacts with HAVCR2; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response. Interacts with XPO1; mediating nuclear export.
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance. Has proangiogenic activity. May be involved in platelet activation. Binds to phosphatidylserine and phosphatidylethanolamide. Bound to RAGE mediates signaling for neuronal outgrowth. May play a role in accumulation of expanded polyglutamine (polyQ) proteins.
messages: Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. May be involved in nucleotide excision repair (NER), mismatch repair (MMR) and base excision repair (BER) pathways, and double strand break repair such as non-homologous end joining (NHEJ). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). In vitro can displace histone H1 from highly bent DNA. Can restructure the canonical nucleosome leading to relaxation of structural constraints for transcription factor-binding. Enhances binding of sterol regulatory element-binding proteins (SREBPs) such as SREBF1 to their cognate DNA sequences and increases their transcriptional activities. Facilitates binding of TP53 to DNA. May be involved in mitochondrial quality control and autophagy in a transcription-dependent fashion implicating HSPB1. Can modulate the activity of the telomerase complex and may be involved in telomere maintenance.
messages: Nucleus
messages: Phosphorylated at serine residues. Phosphorylation in both NLS regions is required for cytoplasmic translocation followed by secretion.
messages: Poly-ADP-ribosylated by PARP1 when secreted following stimulation with LPS.
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins.

9483:CAPN14
gene id: 9483:CAPN14
uniprot id: F7I3J8
names: Similarity
messages: Belongs to the peptidase C2 family.

9483:NGLY1
gene id: 9483:NGLY1
uniprot id: F6PRJ8
uniprot id: F6TYG1
uniprot id: F7AI61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

9483:DEUP1
gene id: 9483:DEUP1
uniprot id: F7EP69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

9483:MED13
gene id: 9483:MED13
uniprot id: F7HQC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:LOC100412918
gene id: 9483:LOC100412918
uniprot id: A0A2R8ME03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:SHC1
gene id: 9483:SHC1
uniprot id: F7C2B3
names: Subcellular Location Annotation
messages: Cytoplasm

9483:CDC37L1
gene id: 9483:CDC37L1
uniprot id: U3BUQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9483:CA9
gene id: 9483:CA9
uniprot id: F7I0J5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9483:ERLEC1
gene id: 9483:ERLEC1
uniprot id: A0A2R8M3S9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

9483:NSUN2
gene id: 9483:NSUN2
uniprot id: F6Y709
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9483:SYN1
gene id: 9483:SYN1
uniprot id: F7I894
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synapsin family.
messages: Golgi apparatus
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: synaptic vesicle

9483:EVL
gene id: 9483:EVL
uniprot id: A0A8J8YCD3
uniprot id: F7I3E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: lamellipodium
messages: stress fiber

9483:NOL10
gene id: 9483:NOL10
uniprot id: F7FQ53
uniprot id: F7GTF1
uniprot id: U3DJD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

9483:LOC100401791
gene id: 9483:LOC100401791
uniprot id: A0A8I3VXS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:FAM221A
gene id: 9483:FAM221A
uniprot id: U3AYF1
names: Similarity
messages: Belongs to the FAM221 family.

9483:TRIM59
gene id: 9483:TRIM59
uniprot id: F7ICN3
names: Subcellular Location Annotation
messages: Cytoplasm

9483:LOC100388954
gene id: 9483:LOC100388954
uniprot id: F7I4Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:KHDRBS2
gene id: 9483:KHDRBS2
uniprot id: F7CWI3
names: Similarity
messages: Belongs to the KHDRBS family.

9483:HSBP1
gene id: 9483:HSBP1
uniprot id: A0A2R8PF30
names: Similarity
messages: Belongs to the HSBP1 family.

9483:ARFGEF1
gene id: 9483:ARFGEF1
uniprot id: U3BBV1
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9483:TNFSF12
gene id: 9483:TNFSF12
uniprot id: F7FJI7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:NKX2-5
gene id: 9483:NKX2-5
uniprot id: A0A8I3X2B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

9483:AGPAT5
gene id: 9483:AGPAT5
uniprot id: F7HJ63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:KCND2
gene id: 9483:KCND2
uniprot id: U3CD42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9483:RPL5
gene id: 9483:RPL5
uniprot id: F7BQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9483:LOC100386651
gene id: 9483:LOC100386651
uniprot id: A0A5F4W5B8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:MOCS1
gene id: 9483:MOCS1
uniprot id: F6TFJ7
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9483:GALNT7
gene id: 9483:GALNT7
uniprot id: F7D606
uniprot id: F7I1I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:ATP8A1
gene id: 9483:ATP8A1
uniprot id: F7H2Q6
uniprot id: U3CLS5
uniprot id: U3ECZ6
uniprot id: U3EDG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9483:GSTO2
gene id: 9483:GSTO2
uniprot id: A0A2R8MSP9
uniprot id: A0A7G3HPU4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9483:FABP12
gene id: 9483:FABP12
uniprot id: F6SDK8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:RTN4
gene id: 9483:RTN4
uniprot id: U3FV09
uniprot id: U3FYH1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:SMPDL3B
gene id: 9483:SMPDL3B
uniprot id: F7I7S8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9483:UBE4A
gene id: 9483:UBE4A
uniprot id: U3AVF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9483:CACNG6
gene id: 9483:CACNG6
uniprot id: A0A2R8N2L8
uniprot id: F7BB41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

9483:BANP
gene id: 9483:BANP
uniprot id: A0A2R8MB62
uniprot id: F7E7Q1
uniprot id: U3CDK2
uniprot id: U3D2P4
uniprot id: U3FSZ4
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9483:WDR45
gene id: 9483:WDR45
uniprot id: F6YLD0
uniprot id: F7HLR4
uniprot id: U3CBW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure

9483:NEK6
gene id: 9483:NEK6
uniprot id: A0A8I3ZZ25
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:MSR1
gene id: 9483:MSR1
uniprot id: F6QM72
names: Subcellular Location Annotation
messages: Membrane

9483:MAP3K8
gene id: 9483:MAP3K8
uniprot id: F7FA86
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9483:NDUFAF1
gene id: 9483:NDUFAF1
uniprot id: F7HZT7
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9483:XKR5
gene id: 9483:XKR5
uniprot id: F6PU51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9483:TRHDE
gene id: 9483:TRHDE
uniprot id: U3F4Q4
names: Similarity
messages: Belongs to the peptidase M1 family.

9483:NTRK3
gene id: 9483:NTRK3
uniprot id: A0A2R8MID4
uniprot id: A0A2R8MR76
uniprot id: A0A2R8NA79
uniprot id: F7E6X3
uniprot id: F7GBZ6
uniprot id: F7GTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane
messages: Mitochondrion

9483:CCNA1
gene id: 9483:CCNA1
uniprot id: F6SIC8
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9483:TMEM208
gene id: 9483:TMEM208
uniprot id: F6RHS7
uniprot id: U3C559
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9483:PMEPA1
gene id: 9483:PMEPA1
uniprot id: U3CP80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9483:SFR1
gene id: 9483:SFR1
uniprot id: F6VV83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9483:SLC35B4
gene id: 9483:SLC35B4
uniprot id: U3D595
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9483:YES1
gene id: 9483:YES1
uniprot id: U3DF65
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:CELF2
gene id: 9483:CELF2
uniprot id: F7HQB0
uniprot id: F7HV57
uniprot id: U3C9H9
uniprot id: U3CJ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9483:B9D2
gene id: 9483:B9D2
uniprot id: F7BH58
names: Subcellular Location Annotation
messages: cilium basal body

9483:TPPP
gene id: 9483:TPPP
uniprot id: U3C144
names: Similarity
messages: Belongs to the TPPP family.

9483:LOC100405332
gene id: 9483:LOC100405332
uniprot id: F6UCC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9483:SYT1
gene id: 9483:SYT1
uniprot id: U3CTJ2
uniprot id: U3EB98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

9483:PAX9
gene id: 9483:PAX9
uniprot id: A0A8P2DCF2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

9483:HBP1
gene id: 9483:HBP1
uniprot id: F7BHX1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9483:AMFR
gene id: 9483:AMFR
uniprot id: U3DJU5
names: Subcellular Location Annotation
messages: Membrane

9483:STAT1
gene id: 9483:STAT1
uniprot id: A0A2R8P3H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9483:SLC25A23
gene id: 9483:SLC25A23
uniprot id: U3DCE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:VAX1
gene id: 9483:VAX1
uniprot id: A0A2R8N321
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

9483:UNC5CL
gene id: 9483:UNC5CL
uniprot id: F6RK11
names: Similarity
messages: Belongs to the unc-5 family.

9483:GMPR2
gene id: 9483:GMPR2
uniprot id: F6SDX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9483:SEC22C
gene id: 9483:SEC22C
uniprot id: F6T5U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9483:ZRANB1
gene id: 9483:ZRANB1
uniprot id: F7III3
uniprot id: U3FPZ0
names: Similarity
messages: Belongs to the peptidase C64 family.

9483:NDUFV1
gene id: 9483:NDUFV1
uniprot id: U3BG69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9483:LOC100411741
gene id: 9483:LOC100411741
uniprot id: F7G3S8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9483:HSPB6
gene id: 9483:HSPB6
uniprot id: F7EBV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9483:PUF60
gene id: 9483:PUF60
uniprot id: A0A8J8XV49
uniprot id: F7ILP2
uniprot id: U3CWN2
uniprot id: U3DDS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

9483:LYN
gene id: 9483:LYN
uniprot id: U3D0I6
uniprot id: U3DUJ3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:PGS1
gene id: 9483:PGS1
uniprot id: F7EXC5
uniprot id: U3EEX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9483:GOSR2
gene id: 9483:GOSR2
uniprot id: U3DCE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9483:TTR
gene id: 9483:TTR
uniprot id: H1AAP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9483:UNC13B
gene id: 9483:UNC13B
uniprot id: U3CPW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-13 family.
messages: Cytoplasm
messages: Membrane

9483:HMGCLL1
gene id: 9483:HMGCLL1
uniprot id: F7H8Z9
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

9483:PICK1
gene id: 9483:PICK1
uniprot id: F6Z9S9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9483:LOC100406834
gene id: 9483:LOC100406834
uniprot id: H9KXU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:GATA3
gene id: 9483:GATA3
uniprot id: U3B1N6
names: Subcellular Location Annotation
messages: Nucleus

9483:BCL2L1
gene id: 9483:BCL2L1
uniprot id: F7IT36
uniprot id: U3CVW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9483:DIPK1A
gene id: 9483:DIPK1A
uniprot id: A0A8I3WV24
uniprot id: F7FIM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9483:LOC100413217
gene id: 9483:LOC100413217
uniprot id: F7FGL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:ACP5
gene id: 9483:ACP5
uniprot id: F6VKK1
names: Cofactor
messages: Binds 2 iron ions per subunit.

9483:LOC100408928
gene id: 9483:LOC100408928
uniprot id: A0A2R8MSY2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:TMEM50B
gene id: 9483:TMEM50B
uniprot id: B0VXG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9483:LOC100390201
gene id: 9483:LOC100390201
uniprot id: A0A2R8MXF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:SLC1A6
gene id: 9483:SLC1A6
uniprot id: U3EGZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9483:LPIN1
gene id: 9483:LPIN1
uniprot id: A0A5F4W9C6
uniprot id: F7I1K8
names: Similarity
messages: Belongs to the lipin family.

9483:OLA1
gene id: 9483:OLA1
uniprot id: U3DTY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

9483:LOC100406123
gene id: 9483:LOC100406123
uniprot id: F7I7Z9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:CNGA1
gene id: 9483:CNGA1
uniprot id: F7I8Y1
names: Function
names: Similarity
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily.
messages: Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.

9483:CA7
gene id: 9483:CA7
uniprot id: F7B798
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9483:BCL7A
gene id: 9483:BCL7A
uniprot id: F6W7A2
uniprot id: U3C447
names: Similarity
messages: Belongs to the BCL7 family.

9483:NOL12
gene id: 9483:NOL12
uniprot id: U3D4W1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9483:MAK16
gene id: 9483:MAK16
uniprot id: F7IJ04
names: Similarity
messages: Belongs to the MAK16 family.

9483:CMC1
gene id: 9483:CMC1
uniprot id: U3CEM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9483:TIMM13
gene id: 9483:TIMM13
uniprot id: U3DE16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9483:PLA1A
gene id: 9483:PLA1A
uniprot id: A0A5F4VSD8
uniprot id: F7A5P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9483:ACTL8
gene id: 9483:ACTL8
uniprot id: F7HR35
names: Similarity
messages: Belongs to the actin family.

9483:OR4C11
gene id: 9483:OR4C11
uniprot id: A0A8I3WNC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:IL1RN
gene id: 9483:IL1RN
uniprot id: F7CCX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9483:ZNF711
gene id: 9483:ZNF711
uniprot id: U3E7M4
names: Subcellular Location Annotation
messages: Nucleus

9483:POPDC3
gene id: 9483:POPDC3
uniprot id: F7GHY4
names: Similarity
messages: Belongs to the popeye family.

9483:RBM3
gene id: 9483:RBM3
uniprot id: U3EBH3
names: Subcellular Location Annotation
messages: Cytoplasm

9483:LOC100405643
gene id: 9483:LOC100405643
uniprot id: F6RXN0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9483:CTH
gene id: 9483:CTH
uniprot id: F7H0R1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9483:PDE4B
gene id: 9483:PDE4B
uniprot id: F7IJN3
uniprot id: U3DD68
uniprot id: U3FTI7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:GOSR1
gene id: 9483:GOSR1
uniprot id: A0A8I3VZ75
uniprot id: F6WJ38
uniprot id: U3DM31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9483:PDK3
gene id: 9483:PDK3
uniprot id: U3DT63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9483:MRPL23
gene id: 9483:MRPL23
uniprot id: U3DBP2
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9483:LOC100387829
gene id: 9483:LOC100387829
uniprot id: A0A2R8P7K0
names: Similarity
messages: Belongs to the MARCKS family.

9483:BRS3
gene id: 9483:BRS3
uniprot id: F7EPZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

9483:CCN1
gene id: 9483:CCN1
uniprot id: F7I1R4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:TM4SF5
gene id: 9483:TM4SF5
uniprot id: F6YBC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9483:MFGE8
gene id: 9483:MFGE8
uniprot id: U3CVI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MMP7
gene id: 9483:MMP7
uniprot id: F7HG57
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

9483:MCUB
gene id: 9483:MCUB
uniprot id: F7I7H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:LZIC
gene id: 9483:LZIC
uniprot id: F7BV86
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9483:ENPP1
gene id: 9483:ENPP1
uniprot id: F7HLD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

9483:PKD2
gene id: 9483:PKD2
uniprot id: A0A5F4W9Q9
uniprot id: F7GM51
uniprot id: U3F411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

9483:TFRC
gene id: 9483:TFRC
uniprot id: H9BFK5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

9483:RBP2
gene id: 9483:RBP2
uniprot id: F7E7T0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:DHX8
gene id: 9483:DHX8
uniprot id: U3DQ08
names: Subcellular Location Annotation
messages: Nucleus

9483:TMEM256
gene id: 9483:TMEM256
uniprot id: F6V825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

9483:LARP7
gene id: 9483:LARP7
uniprot id: A0A5F4W7D3
uniprot id: A0A5K1U6J8
uniprot id: U3EBY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LARP7 family.
messages: nucleoplasm

9483:RBP5
gene id: 9483:RBP5
uniprot id: F7IF66
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:CHD8
gene id: 9483:CHD8
uniprot id: A0A5K1TW24
uniprot id: A0A8J8XI99
uniprot id: F6Y0N8
uniprot id: F7B453
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
messages: Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Sumoylated.

9483:TGFA
gene id: 9483:TGFA
uniprot id: A0A5F4VXH7
uniprot id: U3E7W0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:STMN4
gene id: 9483:STMN4
uniprot id: A0A8I3WA26
uniprot id: F6QV67
uniprot id: U3FXQ2
names: Similarity
messages: Belongs to the stathmin family.

9483:JAK1
gene id: 9483:JAK1
uniprot id: U3BR01
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9483:C20H16orf87
gene id: 9483:C20H16orf87
uniprot id: U3DQJ4
names: Similarity
messages: Belongs to the UPF0547 family.

9483:COMT
gene id: 9483:COMT
uniprot id: U3CQ46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
messages: Cell membrane

9483:NXPH2
gene id: 9483:NXPH2
uniprot id: A0A8I3WVL7
uniprot id: F7BCB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9483:GRK3
gene id: 9483:GRK3
uniprot id: U3FQ72
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9483:CHSY1
gene id: 9483:CHSY1
uniprot id: F7HY89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9483:LZTS2
gene id: 9483:LZTS2
uniprot id: A0A8J8XFH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9483:VPS35
gene id: 9483:VPS35
uniprot id: F7H0E8
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9483:EPHB4
gene id: 9483:EPHB4
uniprot id: F7GUF2
uniprot id: U3BYP0
names: Subcellular Location Annotation
messages: Membrane

9483:PSMB2
gene id: 9483:PSMB2
uniprot id: U3BW63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:MDGA2
gene id: 9483:MDGA2
uniprot id: U3DEF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:TRIM35
gene id: 9483:TRIM35
uniprot id: A0A5F4WL92
uniprot id: U3FRK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:PSMD7
gene id: 9483:PSMD7
uniprot id: F7E772
names: Similarity
messages: Belongs to the peptidase M67A family.

9483:SORCS3
gene id: 9483:SORCS3
uniprot id: F6YYH9
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9483:RDX
gene id: 9483:RDX
uniprot id: F7IGB5
uniprot id: U3D3L7
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9483:LZTFL1
gene id: 9483:LZTFL1
uniprot id: U3F3Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9483:SNTB1
gene id: 9483:SNTB1
uniprot id: U3BJ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9483:HHATL
gene id: 9483:HHATL
uniprot id: U3D168
names: Subcellular Location Annotation
messages: Membrane

9483:TRHR
gene id: 9483:TRHR
uniprot id: F7HI57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9483:BTNL9
gene id: 9483:BTNL9
uniprot id: F7I3I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane
messages: Nucleus

9483:WASHC3
gene id: 9483:WASHC3
uniprot id: A0A8I4A1Z1
uniprot id: F7I4Q8
uniprot id: U3FE08
names: Similarity
messages: Belongs to the CCDC53 family.

9483:TBC1D24
gene id: 9483:TBC1D24
uniprot id: F7G5C2
uniprot id: F7G5L0
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse
messages: Synapse

9483:RBP4
gene id: 9483:RBP4
uniprot id: U3DZ51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

9483:PADI1
gene id: 9483:PADI1
uniprot id: F7IT96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9483:ERFL
gene id: 9483:ERFL
uniprot id: F7GS67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:CPLANE2
gene id: 9483:CPLANE2
uniprot id: F7E9N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

9483:TMEM88B
gene id: 9483:TMEM88B
uniprot id: F7GWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9483:CDK4
gene id: 9483:CDK4
uniprot id: F7DPY6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ANXA7
gene id: 9483:ANXA7
uniprot id: F7DW50
uniprot id: F7EAB2
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9483:HSD17B4
gene id: 9483:HSD17B4
uniprot id: U3EKB5
names: Subcellular Location Annotation
messages: Peroxisome

9483:SERPINB11
gene id: 9483:SERPINB11
uniprot id: F7E504
names: Similarity
messages: Belongs to the serpin family.

9483:DHRS7C
gene id: 9483:DHRS7C
uniprot id: F7II92
uniprot id: U3FD97
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:E2F7
gene id: 9483:E2F7
uniprot id: A0A2R8M8J5
uniprot id: F7E4B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9483:PLRG1
gene id: 9483:PLRG1
uniprot id: F7H4T9
uniprot id: U3AV01
uniprot id: U3DWJ5
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9483:HSD17B2
gene id: 9483:HSD17B2
uniprot id: F6VR90
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:TRIM4
gene id: 9483:TRIM4
uniprot id: F6UD69
uniprot id: F7CQC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:MCM2
gene id: 9483:MCM2
uniprot id: U3APR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9483:FARSB
gene id: 9483:FARSB
uniprot id: F7HYR5
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9483:YIPF4
gene id: 9483:YIPF4
uniprot id: U3C455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9483:SPG21
gene id: 9483:SPG21
uniprot id: U3DFP9
names: Function
names: Subunit
messages: Interacts with CD4. Interacts with ALDH16A1.
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9483:LOC100390666
gene id: 9483:LOC100390666
uniprot id: F7I248
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

9483:HOXD1
gene id: 9483:HOXD1
uniprot id: F7EML3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9483:ATP9A
gene id: 9483:ATP9A
uniprot id: U3BDB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9483:SLC6A1
gene id: 9483:SLC6A1
uniprot id: U3ENW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9483:HSDL2
gene id: 9483:HSDL2
uniprot id: F7C1H1
uniprot id: U3FND2
names: Subcellular Location Annotation
messages: Peroxisome

9483:LOC100410514
gene id: 9483:LOC100410514
uniprot id: A0A8I3W3G2
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9483:C9H12orf57
gene id: 9483:C9H12orf57
uniprot id: U3BEU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

9483:MTNR1A
gene id: 9483:MTNR1A
uniprot id: F6VX53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9483:LOC100409166
gene id: 9483:LOC100409166
uniprot id: F7I5Q9
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9483:SLC16A13
gene id: 9483:SLC16A13
uniprot id: F7HT83
names: Subcellular Location Annotation
messages: Membrane

9483:DSP
gene id: 9483:DSP
uniprot id: F7DT28
names: Subcellular Location Annotation
messages: cytoskeleton

9483:LYPLA1
gene id: 9483:LYPLA1
uniprot id: F6R2S9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9483:APOA2
gene id: 9483:APOA2
uniprot id: U3CMR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A2 family.
messages: Secreted

9483:TENT5A
gene id: 9483:TENT5A
uniprot id: A0A2R8MMQ7
names: Similarity
messages: Belongs to the TENT family.

9483:GNB1
gene id: 9483:GNB1
uniprot id: U3BCS5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9483:RFC1
gene id: 9483:RFC1
uniprot id: U3EL55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

9483:PIGC
gene id: 9483:PIGC
uniprot id: F7HL53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

9483:SCFD1
gene id: 9483:SCFD1
uniprot id: F7ISQ5
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9483:OCM2
gene id: 9483:OCM2
uniprot id: F7B9H4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9483:NIPA2
gene id: 9483:NIPA2
uniprot id: F7DQD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9483:MFSD3
gene id: 9483:MFSD3
uniprot id: F7G427
names: Subcellular Location Annotation
messages: Membrane

9483:RAD1
gene id: 9483:RAD1
uniprot id: A0A8I3W542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9483:LOC100389168
gene id: 9483:LOC100389168
uniprot id: A0A8I3X340
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:RPL36
gene id: 9483:RPL36
uniprot id: F7IRR7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9483:DDX58
gene id: 9483:DDX58
uniprot id: F7IL46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9483:TAFA2
gene id: 9483:TAFA2
uniprot id: F7DMM8
names: Similarity
messages: Belongs to the TAFA family.

9483:EDA
gene id: 9483:EDA
uniprot id: A0A0U5J5L9
uniprot id: A0A2R8N1B1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:PNPLA7
gene id: 9483:PNPLA7
uniprot id: U3FPM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:GALR1
gene id: 9483:GALR1
uniprot id: A0A8I3WUP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:PUS3
gene id: 9483:PUS3
uniprot id: F7GU24
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9483:EXOC2
gene id: 9483:EXOC2
uniprot id: F7GMW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9483:ABL2
gene id: 9483:ABL2
uniprot id: A0A2R8MAK2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:PSMB6
gene id: 9483:PSMB6
uniprot id: F6ZUS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:MEPCE
gene id: 9483:MEPCE
uniprot id: U3E6A8
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9483:INTS2
gene id: 9483:INTS2
uniprot id: A0A8J8XMZ6
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

9483:OLFR561
gene id: 9483:OLFR561
uniprot id: B0VX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CDC34
gene id: 9483:CDC34
uniprot id: U3FKL5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:CAT
gene id: 9483:CAT
uniprot id: Q2I6W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
messages: Homotetramer. Interacts (via microbody targeting signal) with PEX5, monomeric form interacts with PEX5, leading to its translocation into peroxisomes.
messages: Peroxisome

9483:ATP6V1B1
gene id: 9483:ATP6V1B1
uniprot id: F7B6Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9483:GNG10
gene id: 9483:GNG10
uniprot id: F7ESA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:PRKCB
gene id: 9483:PRKCB
uniprot id: F7I4K8
uniprot id: U3EAU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9483:ANKRD13A
gene id: 9483:ANKRD13A
uniprot id: U3BR76
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9483:ABT1
gene id: 9483:ABT1
uniprot id: F7G966
uniprot id: U3ASY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

9483:HPDL
gene id: 9483:HPDL
uniprot id: F7DDE2
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

9483:SEC61A2
gene id: 9483:SEC61A2
uniprot id: A0A8I3WE13
uniprot id: H9KXE4
uniprot id: H9KXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:LOC100407794
gene id: 9483:LOC100407794
uniprot id: A0A2R8NDJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9483:RAB27A
gene id: 9483:RAB27A
uniprot id: F7C0F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

9483:LOC108587700
gene id: 9483:LOC108587700
uniprot id: F7EBE1
names: Similarity
messages: Belongs to the SNURF family.

9483:CALB2
gene id: 9483:CALB2
uniprot id: F7DD39
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9483:SUGT1
gene id: 9483:SUGT1
uniprot id: F7HGA2
names: Similarity
messages: Belongs to the SGT1 family.

9483:HNF4G
gene id: 9483:HNF4G
uniprot id: A0A8I3WG28
uniprot id: F6WNW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9483:ARL8A
gene id: 9483:ARL8A
uniprot id: F7I8B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

9483:ZUP1
gene id: 9483:ZUP1
uniprot id: U3DBX6
uniprot id: U3EEL3
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9483:UBE3A
gene id: 9483:UBE3A
uniprot id: A0A2R8N2Q5
uniprot id: U3EB97
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

9483:SURF4
gene id: 9483:SURF4
uniprot id: U3D3Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

9483:MFAP5
gene id: 9483:MFAP5
uniprot id: A0A2R8PJE2
uniprot id: F7IIE9
uniprot id: U3DPH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9483:SUGP1
gene id: 9483:SUGP1
uniprot id: U3E6Y9
names: Subcellular Location Annotation
messages: Nucleus

9483:EDC3
gene id: 9483:EDC3
uniprot id: F7ERK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

9483:TGM1
gene id: 9483:TGM1
uniprot id: A0A8J8XY53
uniprot id: F7H2Y5
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9483:UBE2H
gene id: 9483:UBE2H
uniprot id: U3DEQ9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:NIPSNAP3A
gene id: 9483:NIPSNAP3A
uniprot id: F7C559
names: Similarity
messages: Belongs to the NipSnap family.

9483:ALDH3A1
gene id: 9483:ALDH3A1
uniprot id: F6YGX5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:ANKS1B
gene id: 9483:ANKS1B
uniprot id: F6YQ59
uniprot id: U3DJM2
names: Subcellular Location Annotation
messages: Cytoplasm

9483:CYB5R2
gene id: 9483:CYB5R2
uniprot id: U3CYL6
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9483:RTN4IP1
gene id: 9483:RTN4IP1
uniprot id: F7IQ43
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9483:RPF2
gene id: 9483:RPF2
uniprot id: U3DYQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9483:CCNE1
gene id: 9483:CCNE1
uniprot id: F7EA63
uniprot id: U3B952
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9483:ATP6V1C1
gene id: 9483:ATP6V1C1
uniprot id: F7INY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9483:F2R
gene id: 9483:F2R
uniprot id: U3F0Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SLC35E3
gene id: 9483:SLC35E3
uniprot id: F7AVQ7
names: Subcellular Location Annotation
messages: Membrane

9483:GPSM2
gene id: 9483:GPSM2
uniprot id: F6T902
uniprot id: U3D953
names: Similarity
messages: Belongs to the GPSM family.

9483:PIR
gene id: 9483:PIR
uniprot id: A0A8I4A1C7
uniprot id: F6TNI5
names: Similarity
messages: Belongs to the pirin family.

9483:TTC39C
gene id: 9483:TTC39C
uniprot id: F6TC78
names: Similarity
messages: Belongs to the TTC39 family.

9483:FGF1
gene id: 9483:FGF1
uniprot id: B0KW92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9483:ATP6V0D1
gene id: 9483:ATP6V0D1
uniprot id: F7HR82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9483:KIF19
gene id: 9483:KIF19
uniprot id: F7ELH6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:TRIM17
gene id: 9483:TRIM17
uniprot id: F7AML3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:LOC100409895
gene id: 9483:LOC100409895
uniprot id: A0A5F4VUR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:FAM155B
gene id: 9483:FAM155B
uniprot id: F7IKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

9483:EMC2
gene id: 9483:EMC2
uniprot id: A0A2R8PEZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

9483:NR1D2
gene id: 9483:NR1D2
uniprot id: U3D5Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9483:SEPTIN7
gene id: 9483:SEPTIN7
uniprot id: F7HWN8
uniprot id: U3EJL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium axoneme
messages: flagellum
messages: kinetochore
messages: spindle

9483:LOC100405850
gene id: 9483:LOC100405850
uniprot id: F7BP63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9483:CUL4B
gene id: 9483:CUL4B
uniprot id: A0A8I3WVL3
uniprot id: A0A8I3ZYC6
uniprot id: F7I872
names: Similarity
messages: Belongs to the cullin family.

9483:AQP2
gene id: 9483:AQP2
uniprot id: F7H018
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:LOC100401718
gene id: 9483:LOC100401718
uniprot id: F7AI40
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9483:PRSS12
gene id: 9483:PRSS12
uniprot id: F7ERX9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

9483:PTPN21
gene id: 9483:PTPN21
uniprot id: U3BTQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9483:ST6GALNAC3
gene id: 9483:ST6GALNAC3
uniprot id: A0A8I4A5R9
uniprot id: F6QAL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:ST6GALNAC4
gene id: 9483:ST6GALNAC4
uniprot id: F6ZK00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:LCTL
gene id: 9483:LCTL
uniprot id: U3EGL4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9483:LIFR
gene id: 9483:LIFR
uniprot id: U3C6U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9483:TMEM87B
gene id: 9483:TMEM87B
uniprot id: F7C6R8
names: Subcellular Location Annotation
messages: Membrane

9483:CCL20
gene id: 9483:CCL20
uniprot id: F7FKP5
uniprot id: U3CWL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:C1QBP
gene id: 9483:C1QBP
uniprot id: F7HBC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

9483:LHFPL2
gene id: 9483:LHFPL2
uniprot id: A0A8I3WQE4
names: Subcellular Location Annotation
messages: Membrane

9483:TULP3
gene id: 9483:TULP3
uniprot id: U3E157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

9483:VPS35L
gene id: 9483:VPS35L
uniprot id: F7IR81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

9483:JUN
gene id: 9483:JUN
uniprot id: U3ED65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9483:PHKB
gene id: 9483:PHKB
uniprot id: A0A2R8MIB9
uniprot id: F7ABD1
uniprot id: U3BJS0
uniprot id: U3E3H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9483:FURIN
gene id: 9483:FURIN
uniprot id: U3FS81
names: Similarity
messages: Belongs to the peptidase S8 family.

9483:PMP2
gene id: 9483:PMP2
uniprot id: F6S344
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9483:FGF11
gene id: 9483:FGF11
uniprot id: F6RHK9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:FAM3B
gene id: 9483:FAM3B
uniprot id: U3BDD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9483:MED30
gene id: 9483:MED30
uniprot id: U3E850
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9483:IGF2BP3
gene id: 9483:IGF2BP3
uniprot id: F7HZQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule

9483:SLC8A3
gene id: 9483:SLC8A3
uniprot id: F7DDU7
uniprot id: F7E9E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9483:CLDN11
gene id: 9483:CLDN11
uniprot id: F6Y431
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:HMCES
gene id: 9483:HMCES
uniprot id: F7H7D8
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

9483:SEC24D
gene id: 9483:SEC24D
uniprot id: U3CPH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9483:ATG9A
gene id: 9483:ATG9A
uniprot id: F6RC33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9483:MTG2
gene id: 9483:MTG2
uniprot id: A0A5F4W3X9
uniprot id: F7HV74
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9483:LHX6
gene id: 9483:LHX6
uniprot id: U3EYD4
names: Subcellular Location Annotation
messages: Nucleus

9483:CYB5RL
gene id: 9483:CYB5RL
uniprot id: U3BEP3
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9483:ADPRHL1
gene id: 9483:ADPRHL1
uniprot id: F6PXM0
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9483:ETFA
gene id: 9483:ETFA
uniprot id: F7EF24
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

9483:TARBP2
gene id: 9483:TARBP2
uniprot id: A0A8I3WQ01
uniprot id: F7ID18
uniprot id: U3BZA3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9483:LOC100390200
gene id: 9483:LOC100390200
uniprot id: U3CI83
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9483:NLN
gene id: 9483:NLN
uniprot id: F7HLQ3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9483:LOC103793369
gene id: 9483:LOC103793369
uniprot id: A0A7R8C3E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:SENP5
gene id: 9483:SENP5
uniprot id: F6UAA3
uniprot id: U3CRE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9483:NR1H3
gene id: 9483:NR1H3
uniprot id: F6UX04
uniprot id: U3FGX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:TRPC5
gene id: 9483:TRPC5
uniprot id: F6Z1I9
names: Subcellular Location Annotation
messages: Membrane

9483:NPL
gene id: 9483:NPL
uniprot id: U3D488
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9483:ERP29
gene id: 9483:ERP29
uniprot id: F7C9F2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

9483:LOC103789626
gene id: 9483:LOC103789626
uniprot id: F7GPI1
names: Similarity
messages: Belongs to the NOP10 family.

9483:TMEM53
gene id: 9483:TMEM53
uniprot id: U3FMU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

9483:ZWILCH
gene id: 9483:ZWILCH
uniprot id: A0A8J8XJB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
messages: kinetochore

9483:PSMC3
gene id: 9483:PSMC3
uniprot id: U3E6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9483:MMS22L
gene id: 9483:MMS22L
uniprot id: A0A8I3X025
uniprot id: F7HVC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Nucleus

9483:CDK7
gene id: 9483:CDK7
uniprot id: F7IRE4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9483:LOC100393797
gene id: 9483:LOC100393797
uniprot id: F7IJU8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9483:MRPS31
gene id: 9483:MRPS31
uniprot id: F7DHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

9483:LOC100397282
gene id: 9483:LOC100397282
uniprot id: U3B7C5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9483:HHEX
gene id: 9483:HHEX
uniprot id: F7G3X7
names: Subcellular Location Annotation
messages: Nucleus

9483:ARL11
gene id: 9483:ARL11
uniprot id: F7HAY2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9483:ARPC3
gene id: 9483:ARPC3
uniprot id: F7IHC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9483:PNPLA8
gene id: 9483:PNPLA8
uniprot id: U3EII8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:IFNAR1
gene id: 9483:IFNAR1
uniprot id: U3CXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

9483:RALB
gene id: 9483:RALB
uniprot id: U3DH43
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9483:EDC4
gene id: 9483:EDC4
uniprot id: A0A5K1UHY1
uniprot id: U3E1X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9483:ACTRT2
gene id: 9483:ACTRT2
uniprot id: A0A2R8P9Q1
names: Similarity
messages: Belongs to the actin family.

9483:DAPK3
gene id: 9483:DAPK3
uniprot id: U3EE09
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:CNKSR3
gene id: 9483:CNKSR3
uniprot id: U3BPL9
names: Similarity
messages: Belongs to the CNKSR family.

9483:XYLB
gene id: 9483:XYLB
uniprot id: F7GVM7
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9483:FBXL5
gene id: 9483:FBXL5
uniprot id: U3ER22
names: Subcellular Location Annotation
messages: perinuclear region

9483:ECHDC1
gene id: 9483:ECHDC1
uniprot id: A0A2R8MQZ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9483:NGFR
gene id: 9483:NGFR
uniprot id: F7C0A9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:POLR2F
gene id: 9483:POLR2F
uniprot id: F7HWV2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9483:ST8SIA3
gene id: 9483:ST8SIA3
uniprot id: F7I126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:OLFR639
gene id: 9483:OLFR639
uniprot id: B0VXC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ASIC4
gene id: 9483:ASIC4
uniprot id: F6RUM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9483:MCEE
gene id: 9483:MCEE
uniprot id: A0A5F4W3C0
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9483:ROM1
gene id: 9483:ROM1
uniprot id: F7IB94
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9483:NECAP2
gene id: 9483:NECAP2
uniprot id: F7DFK6
uniprot id: F7DFL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9483:GNB4
gene id: 9483:GNB4
uniprot id: F7DRF8
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9483:TFE3
gene id: 9483:TFE3
uniprot id: U3C9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9483:C20H16orf70
gene id: 9483:C20H16orf70
uniprot id: F6UKG3
names: Similarity
messages: Belongs to the PHAF1 family.

9483:LOC100388732
gene id: 9483:LOC100388732
uniprot id: B0VXB5
uniprot id: Q9GJS7
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
messages: Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).
messages: Red blood cells.

9483:NR3C2
gene id: 9483:NR3C2
uniprot id: A0A5K1VLS8
uniprot id: Q6XLI8
uniprot id: U3BUE6
names: Subcellular Location Annotation
messages: Nucleus

9483:ZC3H12C
gene id: 9483:ZC3H12C
uniprot id: A0A8I3WP39
names: Similarity
messages: Belongs to the ZC3H12 family.

9483:PLA2G1B
gene id: 9483:PLA2G1B
uniprot id: F7G478
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9483:TRIM54
gene id: 9483:TRIM54
uniprot id: F6YC50
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

9483:OSTC
gene id: 9483:OSTC
uniprot id: F7HL75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9483:LOC100389034
gene id: 9483:LOC100389034
uniprot id: A0A8I4A4Y0
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9483:EFNA5
gene id: 9483:EFNA5
uniprot id: A0A2R8MDR2
uniprot id: U3CAF9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:UBE2R2
gene id: 9483:UBE2R2
uniprot id: F7E9R9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:SERINC4
gene id: 9483:SERINC4
uniprot id: F6XD46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9483:ADRB1
gene id: 9483:ADRB1
uniprot id: F7GC16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:GALNT1
gene id: 9483:GALNT1
uniprot id: U3BYF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:BCAP31
gene id: 9483:BCAP31
uniprot id: F7FI52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9483:SGSM1
gene id: 9483:SGSM1
uniprot id: F7HLL0
uniprot id: U3DVM6
names: Similarity
messages: Belongs to the RUTBC family.

9483:P2RX4
gene id: 9483:P2RX4
uniprot id: U3EJY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9483:TBXAS1
gene id: 9483:TBXAS1
uniprot id: U3DSB5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:HDAC3
gene id: 9483:HDAC3
uniprot id: F6RM17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9483:TDRD5
gene id: 9483:TDRD5
uniprot id: F7IN59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

9483:C1QA
gene id: 9483:C1QA
uniprot id: A0A3B0J183
names: Function
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

9483:PNMA2
gene id: 9483:PNMA2
uniprot id: F7I4S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNMA family.
messages: nucleolus

9483:ANXA10
gene id: 9483:ANXA10
uniprot id: F7IS42
names: Similarity
messages: Belongs to the annexin family.

9483:CLCC1
gene id: 9483:CLCC1
uniprot id: U3DC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

9483:USP37
gene id: 9483:USP37
uniprot id: F7ES35
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:SUPT16H
gene id: 9483:SUPT16H
uniprot id: F7I120
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9483:RNASE12
gene id: 9483:RNASE12
uniprot id: F7G5R4
uniprot id: W0UVB8
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9483:HTRA3
gene id: 9483:HTRA3
uniprot id: A0A8I3WX49
uniprot id: F7CCB8
names: Similarity
messages: Belongs to the peptidase S1C family.

9483:LOC108590593
gene id: 9483:LOC108590593
uniprot id: F7H244
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9483:AASS
gene id: 9483:AASS
uniprot id: F7I9Y6
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9483:GPC4
gene id: 9483:GPC4
uniprot id: F6W6Z1
uniprot id: U3DQ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9483:CRBN
gene id: 9483:CRBN
uniprot id: U3FF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9483:TRIQK
gene id: 9483:TRIQK
uniprot id: F7GTE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIQK family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:CASP14
gene id: 9483:CASP14
uniprot id: F7HWS2
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:NDUFA8
gene id: 9483:NDUFA8
uniprot id: F7CDP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9483:RNMT
gene id: 9483:RNMT
uniprot id: U3EIZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9483:LOC100398744
gene id: 9483:LOC100398744
uniprot id: A0A8I4A1P1
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

9483:CFAP299
gene id: 9483:CFAP299
uniprot id: F7HER8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

9483:CPT2
gene id: 9483:CPT2
uniprot id: F7IPZ3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9483:PTP4A1
gene id: 9483:PTP4A1
uniprot id: F7DW77
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9483:AQP9
gene id: 9483:AQP9
uniprot id: A0A8I3WZ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:SEPTIN2
gene id: 9483:SEPTIN2
uniprot id: U3FNX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9483:WARS1
gene id: 9483:WARS1
uniprot id: A0A8J8YCI7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:ABCD4
gene id: 9483:ABCD4
uniprot id: U3CTD7
names: Function
names: Subunit
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:HSP90B1
gene id: 9483:HSP90B1
uniprot id: U3CJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9483:SPPL2A
gene id: 9483:SPPL2A
uniprot id: A0A8I3W3L8
uniprot id: A0A8I3WJM1
uniprot id: U3DW22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9483:NDUFS1
gene id: 9483:NDUFS1
uniprot id: A0A8I3WKW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

9483:TMEM170A
gene id: 9483:TMEM170A
uniprot id: F7ITE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9483:TRAM1
gene id: 9483:TRAM1
uniprot id: F7INC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9483:KXD1
gene id: 9483:KXD1
uniprot id: F6XQT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9483:RICTOR
gene id: 9483:RICTOR
uniprot id: F7HVJ0
uniprot id: F7HXW1
uniprot id: U3DS95
names: Similarity
messages: Belongs to the RICTOR family.

9483:SH3BP5L
gene id: 9483:SH3BP5L
uniprot id: F7IK25
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9483:SEMA3F
gene id: 9483:SEMA3F
uniprot id: U3EFR7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:HNRNPH1
gene id: 9483:HNRNPH1
uniprot id: A0A2R8MX49
uniprot id: F7AFN0
uniprot id: F7ECV0
names: Subcellular Location Annotation
messages: nucleoplasm

9483:PLLP
gene id: 9483:PLLP
uniprot id: F7H4F3
names: Subcellular Location Annotation
messages: Membrane

9483:IDS
gene id: 9483:IDS
uniprot id: F7EJG2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9483:EEF1G
gene id: 9483:EEF1G
uniprot id: F7IIA9
uniprot id: U3FNE8
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9483:LOC108588767
gene id: 9483:LOC108588767
uniprot id: A0A5F4W951
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:TAS1R2
gene id: 9483:TAS1R2
uniprot id: F6VWQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:SLC27A6
gene id: 9483:SLC27A6
uniprot id: F7H7P5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:OOEP
gene id: 9483:OOEP
uniprot id: B0KWA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDC1 family.
messages: Cytoplasm
messages: Nucleus

9483:ELK4
gene id: 9483:ELK4
uniprot id: U3FE22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:RSBN1L
gene id: 9483:RSBN1L
uniprot id: F7I6G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9483:PMS1
gene id: 9483:PMS1
uniprot id: F7F052
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9483:LOC100405864
gene id: 9483:LOC100405864
uniprot id: A7E3J3
names: Subcellular Location Annotation
messages: Nucleus

9483:FAM98C
gene id: 9483:FAM98C
uniprot id: F6YIR8
names: Similarity
messages: Belongs to the FAM98 family.

9483:ADAM23
gene id: 9483:ADAM23
uniprot id: A0A5F4VY19
uniprot id: A0A5F4WMR5
uniprot id: F7HTE8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MRPS2
gene id: 9483:MRPS2
uniprot id: F6TRS0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

9483:FAXC
gene id: 9483:FAXC
uniprot id: F7IL59
names: Similarity
messages: Belongs to the FAX family.

9483:AZIN1
gene id: 9483:AZIN1
uniprot id: F6RSV2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9483:HMX2
gene id: 9483:HMX2
uniprot id: F7BVY3
names: Subcellular Location Annotation
messages: Nucleus

9483:C12H10orf53
gene id: 9483:C12H10orf53
uniprot id: F7H8W0
names: Similarity
messages: Belongs to the UPF0728 family.

9483:DNAAF4
gene id: 9483:DNAAF4
uniprot id: F6WBM2
uniprot id: U3E2B1
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: neuron projection

9483:DPY19L3
gene id: 9483:DPY19L3
uniprot id: A0A2R8MVF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9483:LOC100896443
gene id: 9483:LOC100896443
uniprot id: F7F2P0
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9483:PGAP2
gene id: 9483:PGAP2
uniprot id: F7BPJ3
uniprot id: U3EUI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9483:TMEM255B
gene id: 9483:TMEM255B
uniprot id: A0A2R8PB99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9483:EIF3F
gene id: 9483:EIF3F
uniprot id: F6PQN1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9483:SLC7A10
gene id: 9483:SLC7A10
uniprot id: F6W3J6
names: Subcellular Location Annotation
messages: Membrane

9483:FAM131B
gene id: 9483:FAM131B
uniprot id: U3FUS4
names: Similarity
messages: Belongs to the FAM131 family.

9483:ATP9B
gene id: 9483:ATP9B
uniprot id: U3FUI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9483:MOK
gene id: 9483:MOK
uniprot id: A0A8I3WSD1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ARHGAP26
gene id: 9483:ARHGAP26
uniprot id: A0A8J8YN80
uniprot id: F6SJA1
uniprot id: U3BZS4
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

9483:GCH1
gene id: 9483:GCH1
uniprot id: U3BK13
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

9483:B4GALNT2
gene id: 9483:B4GALNT2
uniprot id: F6ZYQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

9483:GCLC
gene id: 9483:GCLC
uniprot id: U3CTQ0
uniprot id: U3DQK7
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

9483:SMAD1
gene id: 9483:SMAD1
uniprot id: U3D284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9483:HSD17B3
gene id: 9483:HSD17B3
uniprot id: A0A8I3W2T7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:CAVIN2
gene id: 9483:CAVIN2
uniprot id: F7F4U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9483:FAM135A
gene id: 9483:FAM135A
uniprot id: A0A2R8MJM7
uniprot id: A0A2R8MX13
uniprot id: A0A8I3W5F0
uniprot id: F7DGS6
uniprot id: U3C872
names: Similarity
messages: Belongs to the FAM135 family.

9483:ETV6
gene id: 9483:ETV6
uniprot id: U3FNJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:LOC100411198
gene id: 9483:LOC100411198
uniprot id: Q9N2D2
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Expressed in adult, not neonate-specific as in other organisms.
messages: Hydrolyzes a variety of proteins.
messages: Inhibited by pepstatin.
messages: Monomer.

9483:RIMKLB
gene id: 9483:RIMKLB
uniprot id: F6ZQC0
names: Similarity
messages: Belongs to the RimK family.

9483:COQ4
gene id: 9483:COQ4
uniprot id: F6WM74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

9483:TMSB10
gene id: 9483:TMSB10
uniprot id: F7FGR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9483:MAST1
gene id: 9483:MAST1
uniprot id: F7IHG3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9483:PCYT1B
gene id: 9483:PCYT1B
uniprot id: A0A5F4VTD9
uniprot id: F7HSY2
uniprot id: F7I5W9
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9483:DARS2
gene id: 9483:DARS2
uniprot id: F7HYM1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

9483:SLC29A4
gene id: 9483:SLC29A4
uniprot id: F7HJK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9483:C6H15orf40
gene id: 9483:C6H15orf40
uniprot id: U3AR95
names: Similarity
messages: Belongs to the UPF0235 family.

9483:AIP
gene id: 9483:AIP
uniprot id: F6YY30
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

9483:CD37
gene id: 9483:CD37
uniprot id: U3C1Z9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:PXMP2
gene id: 9483:PXMP2
uniprot id: U3DB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9483:FGGY
gene id: 9483:FGGY
uniprot id: U3F890
names: Similarity
messages: Belongs to the FGGY kinase family.

9483:GPR15
gene id: 9483:GPR15
uniprot id: F7GUM7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:ALDH4A1
gene id: 9483:ALDH4A1
uniprot id: F6ZZR3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:ZNF18
gene id: 9483:ZNF18
uniprot id: A0A2R8MCE1
uniprot id: F7HMB1
uniprot id: U3CC84
names: Subcellular Location Annotation
messages: Nucleus

9483:IRF2BP1
gene id: 9483:IRF2BP1
uniprot id: U3CWM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9483:KATNB1
gene id: 9483:KATNB1
uniprot id: F6T3R8
uniprot id: U3CR17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9483:LOC100385257
gene id: 9483:LOC100385257
uniprot id: U3D2S2
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:UMOD
gene id: 9483:UMOD
uniprot id: F7ILQ4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

9483:ATP5MC1
gene id: 9483:ATP5MC1
uniprot id: A0A5F4VT63
uniprot id: A0A8I3VYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9483:ASF1B
gene id: 9483:ASF1B
uniprot id: A0A2R8P9F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9483:ALOX5
gene id: 9483:ALOX5
uniprot id: U3BAW7
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TGFBI
gene id: 9483:TGFBI
uniprot id: U3D692
names: Subcellular Location Annotation
messages: extracellular matrix

9483:VCP
gene id: 9483:VCP
uniprot id: U3EUB9
names: Similarity
messages: Belongs to the AAA ATPase family.

9483:TTC19
gene id: 9483:TTC19
uniprot id: U3CQJ1
names: Similarity
messages: Belongs to the TTC19 family.

9483:CNDP2
gene id: 9483:CNDP2
uniprot id: F7HVP6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

9483:MTHFS
gene id: 9483:MTHFS
uniprot id: U3CWB8
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

9483:CENPO
gene id: 9483:CENPO
uniprot id: A0A2R8MYD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9483:SLC44A3
gene id: 9483:SLC44A3
uniprot id: F6Q434
uniprot id: U3D2I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9483:TAMM41
gene id: 9483:TAMM41
uniprot id: A0A2R8MH54
uniprot id: F7BR22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9483:SLC25A38
gene id: 9483:SLC25A38
uniprot id: A0A5F4VR98
uniprot id: F7I7I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9483:HAL
gene id: 9483:HAL
uniprot id: F6YL38
names: Similarity
messages: Belongs to the PAL/histidase family.

9483:FUT10
gene id: 9483:FUT10
uniprot id: U3EP63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

9483:ZDHHC16
gene id: 9483:ZDHHC16
uniprot id: U3CMU1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:SLU7
gene id: 9483:SLU7
uniprot id: U3DZ06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9483:PICALM
gene id: 9483:PICALM
uniprot id: A0A2R8N784
uniprot id: F7IBR4
uniprot id: F7IE54
uniprot id: U3BSF3
uniprot id: U3CPA6
uniprot id: U3DBE5
uniprot id: U3FFE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9483:TOP3B
gene id: 9483:TOP3B
uniprot id: F7ADD1
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9483:GRID1
gene id: 9483:GRID1
uniprot id: U3EE85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9483:LOC100389781
gene id: 9483:LOC100389781
uniprot id: U3DFP9
names: Function
names: Subunit
messages: Interacts with CD4. Interacts with ALDH16A1.
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

9483:CMBL
gene id: 9483:CMBL
uniprot id: U3DFD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9483:INTS11
gene id: 9483:INTS11
uniprot id: F7ERB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Nucleus

9483:GAL3ST1
gene id: 9483:GAL3ST1
uniprot id: F7BJM8
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9483:DCLK2
gene id: 9483:DCLK2
uniprot id: F6YPI4
uniprot id: U3DBF3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9483:AK8
gene id: 9483:AK8
uniprot id: U3CCA3
names: Similarity
messages: Belongs to the adenylate kinase family.

9483:SOX10
gene id: 9483:SOX10
uniprot id: F6XMN9
names: Subcellular Location Annotation
messages: Nucleus

9483:LPAR2
gene id: 9483:LPAR2
uniprot id: U3DEU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:UQCRQ
gene id: 9483:UQCRQ
uniprot id: F7FA82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9483:ACTRT3
gene id: 9483:ACTRT3
uniprot id: F7AKM4
names: Similarity
messages: Belongs to the actin family.

9483:NPR3
gene id: 9483:NPR3
uniprot id: F7I3P2
names: Subcellular Location Annotation
messages: Membrane

9483:NR5A2
gene id: 9483:NR5A2
uniprot id: A0A2R8MHR1
uniprot id: F7I1I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9483:EIF3H
gene id: 9483:EIF3H
uniprot id: U3CCN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9483:SSR3
gene id: 9483:SSR3
uniprot id: F7IFI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9483:CHST11
gene id: 9483:CHST11
uniprot id: F7F2M8
uniprot id: U3CLY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:CDX1
gene id: 9483:CDX1
uniprot id: F7G6D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9483:HOATZ
gene id: 9483:HOATZ
uniprot id: A0A8I3W111
uniprot id: F6QYF5
names: Similarity
messages: Belongs to the HOATZ family.

9483:MCM8
gene id: 9483:MCM8
uniprot id: F7GG92
uniprot id: F7GG99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9483:OCLN
gene id: 9483:OCLN
uniprot id: F7INV8
uniprot id: U3EJL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

9483:NDUFS5
gene id: 9483:NDUFS5
uniprot id: F7B8U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9483:MON1B
gene id: 9483:MON1B
uniprot id: F6VWD1
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9483:LOC100409051
gene id: 9483:LOC100409051
uniprot id: A0A8I3WHX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TMOD3
gene id: 9483:TMOD3
uniprot id: F7BX02
names: Subcellular Location Annotation
messages: cytoskeleton

9483:CHAC2
gene id: 9483:CHAC2
uniprot id: A0A5F4WMD6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9483:PRNP
gene id: 9483:PRNP
uniprot id: A0A2R8MM57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane

9483:GDF15
gene id: 9483:GDF15
uniprot id: A0A2R8ND08
names: Similarity
messages: Belongs to the TGF-beta family.

9483:RPS6KA6
gene id: 9483:RPS6KA6
uniprot id: U3CR58
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9483:UBAC1
gene id: 9483:UBAC1
uniprot id: U3E1V9
names: Subcellular Location Annotation
messages: Cytoplasm

9483:EXOC4
gene id: 9483:EXOC4
uniprot id: U3F757
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9483:PAQR4
gene id: 9483:PAQR4
uniprot id: F6XFB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9483:CYP20A1
gene id: 9483:CYP20A1
uniprot id: U3ELF2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:UBE2B
gene id: 9483:UBE2B
uniprot id: F7HM77
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:NAP1L4
gene id: 9483:NAP1L4
uniprot id: A0A5F4VVM7
uniprot id: F6S917
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:TRIM28
gene id: 9483:TRIM28
uniprot id: U3E3Y4
names: Subcellular Location Annotation
messages: Cytoplasm

9483:COMTD1
gene id: 9483:COMTD1
uniprot id: F6X318
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9483:CCL19
gene id: 9483:CCL19
uniprot id: F7BQ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:B2M
gene id: 9483:B2M
uniprot id: P63061
uniprot id: U3FI69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.
messages: Secreted

9483:NPAS3
gene id: 9483:NPAS3
uniprot id: A0A2R8M666
names: Subcellular Location Annotation
messages: Nucleus

9483:UPF1
gene id: 9483:UPF1
uniprot id: F7HDF7
uniprot id: U3D5B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

9483:TFEC
gene id: 9483:TFEC
uniprot id: A0A2R8MDP8
uniprot id: A0A2R8MPG5
uniprot id: A0A2R8N2I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9483:SIX1
gene id: 9483:SIX1
uniprot id: F7I8P1
uniprot id: U3E127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

9483:GK
gene id: 9483:GK
uniprot id: A0A2R8MDU3
uniprot id: A0A5K1VG34
uniprot id: F7A4R7
uniprot id: U3D3V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9483:UTP15
gene id: 9483:UTP15
uniprot id: U3ANT8
names: Subcellular Location Annotation
messages: nucleolus

9483:S100A11
gene id: 9483:S100A11
uniprot id: F7DD73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

9483:RALA
gene id: 9483:RALA
uniprot id: F7IEB0
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9483:SYT16
gene id: 9483:SYT16
uniprot id: F7B0F6
names: Similarity
messages: Belongs to the synaptotagmin family.

9483:ACTG2
gene id: 9483:ACTG2
uniprot id: F6PL61
names: Similarity
messages: Belongs to the actin family.

9483:PELI3
gene id: 9483:PELI3
uniprot id: U3C2T5
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9483:LYRM4
gene id: 9483:LYRM4
uniprot id: U3DUB0
names: Similarity
messages: Belongs to the complex I LYR family.

9483:FGF23
gene id: 9483:FGF23
uniprot id: A0A8I3WME0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:SYT17
gene id: 9483:SYT17
uniprot id: F7HH86
uniprot id: U3ETE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

9483:TXN
gene id: 9483:TXN
uniprot id: Q9BDJ3
uniprot id: U3CTN3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioredoxin family.
messages: Cytoplasm
messages: Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner (By similarity).
messages: In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins (By similarity).
messages: Nucleus
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
messages: Secreted

9483:PHTF1
gene id: 9483:PHTF1
uniprot id: U3FJ49
names: Subcellular Location Annotation
messages: Membrane

9483:AIF1
gene id: 9483:AIF1
uniprot id: U3D2H7
names: Subcellular Location Annotation
messages: ruffle membrane

9483:HTR2C
gene id: 9483:HTR2C
uniprot id: F6S1A5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MPDZ. Interacts with ARRB2.
messages: Membrane

9483:PLPBP
gene id: 9483:PLPBP
uniprot id: F7I3A2
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9483:FMO2
gene id: 9483:FMO2
uniprot id: A0A221I0G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9483:PGLYRP1
gene id: 9483:PGLYRP1
uniprot id: F6V9G7
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9483:TRMU
gene id: 9483:TRMU
uniprot id: F7D8I5
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

9483:FUT9
gene id: 9483:FUT9
uniprot id: F7I511
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9483:TIMP3
gene id: 9483:TIMP3
uniprot id: B0KWT4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts with EFEMP1.
messages: extracellular matrix

9483:GUCY1A1
gene id: 9483:GUCY1A1
uniprot id: F7IRP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9483:DOK1
gene id: 9483:DOK1
uniprot id: F7GS04
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9483:KCNN4
gene id: 9483:KCNN4
uniprot id: F6PPT3
names: Subcellular Location Annotation
messages: Membrane

9483:OLFR651
gene id: 9483:OLFR651
uniprot id: B0VXD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:GLS
gene id: 9483:GLS
uniprot id: F6YA69
uniprot id: F6Z2D2
names: Similarity
messages: Belongs to the glutaminase family.

9483:PARP9
gene id: 9483:PARP9
uniprot id: F7IBF8
uniprot id: U3DWP6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:PLAC8L1
gene id: 9483:PLAC8L1
uniprot id: F7DT58
names: Similarity
messages: Belongs to the cornifelin family.

9483:MTMR6
gene id: 9483:MTMR6
uniprot id: F7GSA1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9483:DPH6
gene id: 9483:DPH6
uniprot id: A0A2R8PGP1
uniprot id: U3BM61
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9483:RYBP
gene id: 9483:RYBP
uniprot id: U3BDG5
names: Subcellular Location Annotation
messages: Nucleus

9483:ARL8B
gene id: 9483:ARL8B
uniprot id: F7I8E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

9483:LOC100403816
gene id: 9483:LOC100403816
uniprot id: F7IA43
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:EIF4ENIF1
gene id: 9483:EIF4ENIF1
uniprot id: B0KWR5
names: Subcellular Location Annotation
messages: Cytoplasm

9483:RPSA
gene id: 9483:RPSA
uniprot id: F7I9W2
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9483:RAN
gene id: 9483:RAN
uniprot id: F6QR16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

9483:FOXO1
gene id: 9483:FOXO1
uniprot id: U3FDL3
names: Subcellular Location Annotation
messages: Nucleus

9483:ND5
gene id: 9483:ND5
uniprot id: A0A0U1XMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9483:EXTL3
gene id: 9483:EXTL3
uniprot id: A0A2R8PFB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:NEK9
gene id: 9483:NEK9
uniprot id: F7I9E1
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9483:FBLN1
gene id: 9483:FBLN1
uniprot id: U3CNK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:ZFP36L1
gene id: 9483:ZFP36L1
uniprot id: A0A5F4W8M9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9483:NACC1
gene id: 9483:NACC1
uniprot id: U3DNX4
names: Subcellular Location Annotation
messages: Nucleus

9483:TAF4B
gene id: 9483:TAF4B
uniprot id: A0A5F4VWY4
uniprot id: A0A5F4WAK9
uniprot id: F7IBK1
uniprot id: U3FQK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

9483:ZIC3
gene id: 9483:ZIC3
uniprot id: F6ZH47
uniprot id: U3ER80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9483:IGFBP4
gene id: 9483:IGFBP4
uniprot id: F6RPW3
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:PDSS2
gene id: 9483:PDSS2
uniprot id: A0A2R8P504
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9483:GSTO1
gene id: 9483:GSTO1
uniprot id: U3DX59
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9483:SYBU
gene id: 9483:SYBU
uniprot id: A0A5F4W3A6
uniprot id: F6SV80
uniprot id: F7H9H4
uniprot id: F7IMS6
names: Subcellular Location Annotation
messages: Membrane

9483:CACYBP
gene id: 9483:CACYBP
uniprot id: U3B8Y1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9483:NMBR
gene id: 9483:NMBR
uniprot id: F7I8P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ITGB3
gene id: 9483:ITGB3
uniprot id: F6QIG8
uniprot id: U3B9A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9483:MRPL43
gene id: 9483:MRPL43
uniprot id: U3E5Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9483:TSPAN13
gene id: 9483:TSPAN13
uniprot id: F7HX26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:KCNJ12
gene id: 9483:KCNJ12
uniprot id: U3ERX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9483:CIAO2A
gene id: 9483:CIAO2A
uniprot id: A0A8I3WYR8
uniprot id: F7IHH5
names: Similarity
messages: Belongs to the MIP18 family.

9483:ASB15
gene id: 9483:ASB15
uniprot id: A0A8I3W2Y7
uniprot id: F7FYF5
uniprot id: U3DDH4
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:NFXL1
gene id: 9483:NFXL1
uniprot id: F7HUR4
names: Similarity
messages: Belongs to the NFX1 family.

9483:CASP10
gene id: 9483:CASP10
uniprot id: U3CWK6
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:TFAP2B
gene id: 9483:TFAP2B
uniprot id: U3EVG1
names: Similarity
messages: Belongs to the AP-2 family.

9483:STMN3
gene id: 9483:STMN3
uniprot id: U3DU69
names: Function
names: Similarity
messages: Belongs to the stathmin family.
messages: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

9483:SLC35B3
gene id: 9483:SLC35B3
uniprot id: A0A8I3W6G3
uniprot id: A0A8I3W9C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9483:OBP2A
gene id: 9483:OBP2A
uniprot id: F6RCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9483:LOC100404354
gene id: 9483:LOC100404354
uniprot id: A0A8I3WBI1
uniprot id: F7INF4
names: Similarity
messages: Belongs to the multicopper oxidase family.

9483:CYP19A1
gene id: 9483:CYP19A1
uniprot id: F7HXX8
uniprot id: Q95M61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
messages: Membrane

9483:IMPDH2
gene id: 9483:IMPDH2
uniprot id: U3BIW7
uniprot id: U3CQ93
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9483:FABP3
gene id: 9483:FABP3
uniprot id: F7DNE1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:DKK2
gene id: 9483:DKK2
uniprot id: A0A5F4WB29
names: Similarity
messages: Belongs to the dickkopf family.

9483:PRDX2
gene id: 9483:PRDX2
uniprot id: U3BQQ2
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9483:VPS72
gene id: 9483:VPS72
uniprot id: U3BS67
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9483:IFNB1
gene id: 9483:IFNB1
uniprot id: A0A7R8C316
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:LOC100385973
gene id: 9483:LOC100385973
uniprot id: A0A2R8M646
names: Similarity
messages: Belongs to the HINT family.

9483:LOC100386291
gene id: 9483:LOC100386291
uniprot id: A0A2R8MI62
names: Subunit
messages: Interacts with hair keratins.

9483:RBP7
gene id: 9483:RBP7
uniprot id: F7HC29
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9483:PDCD5
gene id: 9483:PDCD5
uniprot id: F6YB48
names: Similarity
messages: Belongs to the PDCD5 family.

9483:MRE11
gene id: 9483:MRE11
uniprot id: U3CS03
uniprot id: U3E822
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9483:TSPYL4
gene id: 9483:TSPYL4
uniprot id: U3FHE0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:LCOR
gene id: 9483:LCOR
uniprot id: F6Z6X6
names: Subcellular Location Annotation
messages: Nucleus

9483:SSR1
gene id: 9483:SSR1
uniprot id: A0A2R8M539
uniprot id: A0A8I3WP53
uniprot id: F7HEU8
uniprot id: F7HEV2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

9483:GLIS3
gene id: 9483:GLIS3
uniprot id: F7D115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9483:ALDH1A3
gene id: 9483:ALDH1A3
uniprot id: A0A8J8YLV6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:FICD
gene id: 9483:FICD
uniprot id: U3D3E3
names: Similarity
messages: Belongs to the fic family.

9483:TMEM14A
gene id: 9483:TMEM14A
uniprot id: U3DCF1
names: Similarity
messages: Belongs to the TMEM14 family.

9483:LOC108593753
gene id: 9483:LOC108593753
uniprot id: U3F605
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9483:MAX
gene id: 9483:MAX
uniprot id: U3C5H8
names: Similarity
messages: Belongs to the MAX family.

9483:PPIL1
gene id: 9483:PPIL1
uniprot id: A0A8I4A5R6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:UCHL1
gene id: 9483:UCHL1
uniprot id: U3FKC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:ASIC5
gene id: 9483:ASIC5
uniprot id: F7GQ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

9483:TAF2
gene id: 9483:TAF2
uniprot id: A0A8I3WW93
uniprot id: U3F1J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

9483:ARL5A
gene id: 9483:ARL5A
uniprot id: F7FTL5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9483:MYMK
gene id: 9483:MYMK
uniprot id: A0A8I4A636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9483:SLC1A5
gene id: 9483:SLC1A5
uniprot id: U3CUP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9483:ATP5MG
gene id: 9483:ATP5MG
uniprot id: F7GSV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9483:PTPN12
gene id: 9483:PTPN12
uniprot id: F7IB84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

9483:FAM155A
gene id: 9483:FAM155A
uniprot id: U3EYU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

9483:DPF1
gene id: 9483:DPF1
uniprot id: A0A5K1VBC6
names: Similarity
messages: Belongs to the requiem/DPF family.

9483:SLC10A2
gene id: 9483:SLC10A2
uniprot id: F7BIG3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

9483:CMTM3
gene id: 9483:CMTM3
uniprot id: A0A8J8XIN1
names: Subcellular Location Annotation
messages: Membrane

9483:EEF1B2
gene id: 9483:EEF1B2
uniprot id: F7GY27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9483:FBN1
gene id: 9483:FBN1
uniprot id: F7ALZ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:DPF3
gene id: 9483:DPF3
uniprot id: F7IKV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the requiem/DPF family.
messages: Nucleus

9483:DR1
gene id: 9483:DR1
uniprot id: A0A2R8MT44
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9483:RGS2
gene id: 9483:RGS2
uniprot id: F7HJN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9483:IFT20
gene id: 9483:IFT20
uniprot id: A0A2R8MRU5
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9483:BDNF
gene id: 9483:BDNF
uniprot id: A0A2R8MWP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
messages: Monomers and homodimers. Binds to NTRK2/TRKB.
messages: Secreted

9483:GPR65
gene id: 9483:GPR65
uniprot id: F6R6D5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:GEM
gene id: 9483:GEM
uniprot id: F7EIY8
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

9483:NR0B2
gene id: 9483:NR0B2
uniprot id: F7H657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9483:RPAIN
gene id: 9483:RPAIN
uniprot id: A0A2R8M5T4
uniprot id: F7GVG1
uniprot id: U3ETR1
names: Subcellular Location Annotation
messages: Nucleus

9483:TAF15
gene id: 9483:TAF15
uniprot id: F7GUE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9483:DENND10
gene id: 9483:DENND10
uniprot id: U3CI95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

9483:STIM1
gene id: 9483:STIM1
uniprot id: U3D8U2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:GPRC5C
gene id: 9483:GPRC5C
uniprot id: F7GH50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:DNAAF6
gene id: 9483:DNAAF6
uniprot id: F7GS79
names: Similarity
messages: Belongs to the PIH1 family.

9483:LHX1
gene id: 9483:LHX1
uniprot id: F6UGX4
names: Subcellular Location Annotation
messages: Nucleus

9483:PUS1
gene id: 9483:PUS1
uniprot id: F7EPT1
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9483:IFNW1
gene id: 9483:IFNW1
uniprot id: A0A7R8C4X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:KRT36
gene id: 9483:KRT36
uniprot id: F7C5X7
names: Similarity
messages: Belongs to the intermediate filament family.

9483:LOC100406994
gene id: 9483:LOC100406994
uniprot id: A0A5F4VRT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SPG7
gene id: 9483:SPG7
uniprot id: A0A2R8MB22
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9483:PAGE3
gene id: 9483:PAGE3
uniprot id: F7CYI6
names: Similarity
messages: Belongs to the GAGE family.

9483:PSMC6
gene id: 9483:PSMC6
uniprot id: F6X828
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9483:VPS16
gene id: 9483:VPS16
uniprot id: U3BHT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9483:RAD21
gene id: 9483:RAD21
uniprot id: F7HYV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9483:LSM1
gene id: 9483:LSM1
uniprot id: F7B4D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

9483:GRK6
gene id: 9483:GRK6
uniprot id: F6QAF7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9483:GLCE
gene id: 9483:GLCE
uniprot id: A0A2R8MWH6
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9483:IWS1
gene id: 9483:IWS1
uniprot id: F7EW11
uniprot id: U3DIT9
names: Subcellular Location Annotation
messages: Nucleus

9483:PFKFB4
gene id: 9483:PFKFB4
uniprot id: U3EVT9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9483:DAP3
gene id: 9483:DAP3
uniprot id: U3EF11
uniprot id: U3EKP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

9483:MGP
gene id: 9483:MGP
uniprot id: F7INT5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9483:FTL
gene id: 9483:FTL
uniprot id: F7G1I6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9483:C5H20orf27
gene id: 9483:C5H20orf27
uniprot id: F7FSS4
names: Similarity
messages: Belongs to the UPF0687 family.

9483:PIK3R2
gene id: 9483:PIK3R2
uniprot id: F6ZCI2
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9483:COQ6
gene id: 9483:COQ6
uniprot id: F6YUG8
uniprot id: U3BRU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

9483:MEOX2
gene id: 9483:MEOX2
uniprot id: F6YFS8
names: Subcellular Location Annotation
messages: Nucleus

9483:VPS45
gene id: 9483:VPS45
uniprot id: U3EPE1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9483:POLB
gene id: 9483:POLB
uniprot id: F7IKW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

9483:SEC23B
gene id: 9483:SEC23B
uniprot id: F7IMB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9483:TUBD1
gene id: 9483:TUBD1
uniprot id: F7I4J4
uniprot id: U3CA49
uniprot id: U3FMD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9483:SLC13A1
gene id: 9483:SLC13A1
uniprot id: A0A2R8P3C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9483:PFDN2
gene id: 9483:PFDN2
uniprot id: F7F6X9
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9483:TLCD3A
gene id: 9483:TLCD3A
uniprot id: F7IEA1
names: Subcellular Location Annotation
messages: Membrane

9483:LOC108591240
gene id: 9483:LOC108591240
uniprot id: F7HQ77
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:DYNC2LI1
gene id: 9483:DYNC2LI1
uniprot id: F6SL64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9483:CORT
gene id: 9483:CORT
uniprot id: F7I1I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9483:TNKS2
gene id: 9483:TNKS2
uniprot id: F7CVA7
uniprot id: U3C2N9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:CSAD
gene id: 9483:CSAD
uniprot id: A0A8I4A5Y3
names: Similarity
messages: Belongs to the group II decarboxylase family.

9483:B3GNT6
gene id: 9483:B3GNT6
uniprot id: A0A2R8M8Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:SPATS2L
gene id: 9483:SPATS2L
uniprot id: A0A5F4WL50
uniprot id: A0A8I3WA21
uniprot id: F7DIM8
uniprot id: F7HVW5
uniprot id: U3DH00
uniprot id: U3ENF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9483:CLDN5
gene id: 9483:CLDN5
uniprot id: A0A2R8MGT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:HACL1
gene id: 9483:HACL1
uniprot id: U3BZ78
uniprot id: U3FTX8
names: Similarity
messages: Belongs to the TPP enzyme family.

9483:MRPS21
gene id: 9483:MRPS21
uniprot id: F7HBX1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9483:FLT1
gene id: 9483:FLT1
uniprot id: A0A2R8NAM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9483:WNT7B
gene id: 9483:WNT7B
uniprot id: U3BHR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:PSENEN
gene id: 9483:PSENEN
uniprot id: F7DH46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9483:UIMC1
gene id: 9483:UIMC1
uniprot id: U3CM25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

9483:CCL5
gene id: 9483:CCL5
uniprot id: A0A5F4W4J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:ESRRA
gene id: 9483:ESRRA
uniprot id: U3BPV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9483:LYRM2
gene id: 9483:LYRM2
uniprot id: F6ZYH3
uniprot id: U3DYW2
names: Similarity
messages: Belongs to the complex I LYR family.

9483:DTNB
gene id: 9483:DTNB
uniprot id: F7GZQ2
uniprot id: F7I815
uniprot id: U3CSD2
uniprot id: U3D7I1
uniprot id: U3EJ80
uniprot id: U3EL65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9483:PLCB2
gene id: 9483:PLCB2
uniprot id: A0A5F4WH25
uniprot id: F7I4D1
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9483:CHRNB2
gene id: 9483:CHRNB2
uniprot id: F7HLC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:OR8D4
gene id: 9483:OR8D4
uniprot id: A0A5F4WEG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:NEFM
gene id: 9483:NEFM
uniprot id: A0A8I3WVA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon
messages: cytoskeleton

9483:TMBIM6
gene id: 9483:TMBIM6
uniprot id: A0A2R8MGV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9483:TIGD7
gene id: 9483:TIGD7
uniprot id: U3F721
names: Subcellular Location Annotation
messages: Nucleus

9483:AMER2
gene id: 9483:AMER2
uniprot id: F7H2Q2
names: Similarity
messages: Belongs to the Amer family.

9483:HHIP
gene id: 9483:HHIP
uniprot id: F6UZU3
uniprot id: U3FQI0
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC100897022
gene id: 9483:LOC100897022
uniprot id: U3FCQ0
names: Similarity
messages: Belongs to the pro/parathymosin family.

9483:KRTCAP2
gene id: 9483:KRTCAP2
uniprot id: A0A2R8M4S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

9483:CKAP5
gene id: 9483:CKAP5
uniprot id: U3EY20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

9483:SRPRB
gene id: 9483:SRPRB
uniprot id: A0A2R8PDK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:SLC1A4
gene id: 9483:SLC1A4
uniprot id: F7FQH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9483:MRPL40
gene id: 9483:MRPL40
uniprot id: U3C174
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9483:IFRD1
gene id: 9483:IFRD1
uniprot id: F7IPH5
names: Similarity
messages: Belongs to the IFRD family.

9483:ADGRL4
gene id: 9483:ADGRL4
uniprot id: F7BJ41
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:NFKB1
gene id: 9483:NFKB1
uniprot id: F6V7I0
uniprot id: U3FK78
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:UTP14A
gene id: 9483:UTP14A
uniprot id: A0A5F4VYY7
uniprot id: F6YKW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

9483:GAR1
gene id: 9483:GAR1
uniprot id: U3B6I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

9483:PPP6R1
gene id: 9483:PPP6R1
uniprot id: U3F4F5
names: Similarity
messages: Belongs to the SAPS family.

9483:CXCR6
gene id: 9483:CXCR6
uniprot id: A0A5F4WCZ6
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

9483:CSRNP3
gene id: 9483:CSRNP3
uniprot id: F6PRX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9483:PAICS
gene id: 9483:PAICS
uniprot id: F6U4J5
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9483:PEX10
gene id: 9483:PEX10
uniprot id: U3FIL9
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9483:BTF3L4
gene id: 9483:BTF3L4
uniprot id: A0A8I3X0P9
uniprot id: F7I0E1
names: Similarity
messages: Belongs to the NAC-beta family.

9483:OR5L1
gene id: 9483:OR5L1
uniprot id: F6Y0U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:B3GAT3
gene id: 9483:B3GAT3
uniprot id: F7IBB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:CDK9
gene id: 9483:CDK9
uniprot id: A0A5K1U9Z8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:S1PR5
gene id: 9483:S1PR5
uniprot id: F6QIC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:ZIC1
gene id: 9483:ZIC1
uniprot id: F7IQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9483:ATP5F1C
gene id: 9483:ATP5F1C
uniprot id: F7I4L8
uniprot id: F7I4N1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9483:ACTA1
gene id: 9483:ACTA1
uniprot id: F7FWZ0
names: Similarity
messages: Belongs to the actin family.

9483:CPVL
gene id: 9483:CPVL
uniprot id: F7GPF2
names: Similarity
messages: Belongs to the peptidase S10 family.

9483:GAL3ST3
gene id: 9483:GAL3ST3
uniprot id: F7G7D8
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9483:GABARAPL2
gene id: 9483:GABARAPL2
uniprot id: F7HV98
names: Similarity
messages: Belongs to the ATG8 family.

9483:GUF1
gene id: 9483:GUF1
uniprot id: F7IQ52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9483:FRG1
gene id: 9483:FRG1
uniprot id: F6QHV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9483:RSPO2
gene id: 9483:RSPO2
uniprot id: U3DVW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9483:IER3IP1
gene id: 9483:IER3IP1
uniprot id: F7HTN1
names: Similarity
messages: Belongs to the YOS1 family.

9483:PTGR2
gene id: 9483:PTGR2
uniprot id: A0A8I3WNV1
uniprot id: F6SLT2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9483:LOC100415625
gene id: 9483:LOC100415625
uniprot id: A0A5F4WEM7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9483:ZP3
gene id: 9483:ZP3
uniprot id: F7I9N9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Membrane
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

9483:DOHH
gene id: 9483:DOHH
uniprot id: F7HA65
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

9483:TSPAN33
gene id: 9483:TSPAN33
uniprot id: U3DV06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:SERPINB10
gene id: 9483:SERPINB10
uniprot id: B0CMB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity).

9483:ANXA5
gene id: 9483:ANXA5
uniprot id: A0A2R8NFT5
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

9483:PALMD
gene id: 9483:PALMD
uniprot id: U3EDL0
names: Similarity
messages: Belongs to the paralemmin family.

9483:MPP7
gene id: 9483:MPP7
uniprot id: F7GFG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

9483:SIX2
gene id: 9483:SIX2
uniprot id: F6Z031
uniprot id: F7I8P1
names: Subcellular Location Annotation
messages: Nucleus

9483:DUSP29
gene id: 9483:DUSP29
uniprot id: F7IJ24
uniprot id: U3DS87
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9483:RPL35
gene id: 9483:RPL35
uniprot id: F7FP32
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

9483:NSMCE2
gene id: 9483:NSMCE2
uniprot id: F7HZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9483:CUL2
gene id: 9483:CUL2
uniprot id: F6SU62
names: Similarity
messages: Belongs to the cullin family.

9483:DDRGK1
gene id: 9483:DDRGK1
uniprot id: F7F1D2
names: Similarity
messages: Belongs to the DDRGK1 family.

9483:DERL3
gene id: 9483:DERL3
uniprot id: H9KWP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9483:FAM133B
gene id: 9483:FAM133B
uniprot id: U3DPH9
names: Similarity
messages: Belongs to the FAM133 family.

9483:ETS1
gene id: 9483:ETS1
uniprot id: F7C4P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

9483:LOC100390127
gene id: 9483:LOC100390127
uniprot id: F7DXQ1
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9483:CMTM6
gene id: 9483:CMTM6
uniprot id: F6RXA3
names: Subcellular Location Annotation
messages: Membrane

9483:KCNJ11
gene id: 9483:KCNJ11
uniprot id: U3AZ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9483:CLPX
gene id: 9483:CLPX
uniprot id: U3DAL1
names: Similarity
messages: Belongs to the ClpX chaperone family.

9483:CLDN14
gene id: 9483:CLDN14
uniprot id: F7C3D9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:ADGRL3
gene id: 9483:ADGRL3
uniprot id: A0A2R8MIU3
uniprot id: A0A2R8MM16
uniprot id: F7IQX7
uniprot id: F7IQX8
names: Subcellular Location Annotation
messages: Membrane

9483:TFEB
gene id: 9483:TFEB
uniprot id: B0KWN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9483:MIOX
gene id: 9483:MIOX
uniprot id: F7I8L5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

9483:MYOZ2
gene id: 9483:MYOZ2
uniprot id: F7IED9
names: Similarity
messages: Belongs to the myozenin family.

9483:SLC28A3
gene id: 9483:SLC28A3
uniprot id: F6TSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9483:NSMCE1
gene id: 9483:NSMCE1
uniprot id: U3DZ29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9483:APOC1
gene id: 9483:APOC1
uniprot id: A0A8I3WXK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C1 family.
messages: Secreted

9483:LBX2
gene id: 9483:LBX2
uniprot id: A0A2R8M7T5
names: Subcellular Location Annotation
messages: Nucleus

9483:LEP
gene id: 9483:LEP
uniprot id: F7HGW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

9483:UTP6
gene id: 9483:UTP6
uniprot id: A0A8I3WP38
uniprot id: F6VAZ6
names: Similarity
messages: Belongs to the UTP6 family.

9483:HYLS1
gene id: 9483:HYLS1
uniprot id: A0A5F4W0K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9483:GNAO1
gene id: 9483:GNAO1
uniprot id: A0A2R8P4V7
uniprot id: F7HNP2
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9483:TMBIM1
gene id: 9483:TMBIM1
uniprot id: F7B0Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9483:NF2
gene id: 9483:NF2
uniprot id: F6QIK4
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9483:PARP8
gene id: 9483:PARP8
uniprot id: U3CCZ6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:B3GNT3
gene id: 9483:B3GNT3
uniprot id: A0A2R8M6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:S100PBP
gene id: 9483:S100PBP
uniprot id: U3DXQ9
names: Subcellular Location Annotation
messages: Nucleus

9483:CASQ2
gene id: 9483:CASQ2
uniprot id: U3FJA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9483:RNF126
gene id: 9483:RNF126
uniprot id: U3F4G0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:LYPD6B
gene id: 9483:LYPD6B
uniprot id: F7ICB9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:RGS7BP
gene id: 9483:RGS7BP
uniprot id: F6XC06
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9483:CD9
gene id: 9483:CD9
uniprot id: U3DYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

9483:NUP50
gene id: 9483:NUP50
uniprot id: F7IC26
names: Subcellular Location Annotation
messages: nuclear pore complex

9483:AGL
gene id: 9483:AGL
uniprot id: A0A8I3WN62
uniprot id: U3DB08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

9483:SRPX
gene id: 9483:SRPX
uniprot id: U3BB10
uniprot id: U3CBQ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CCR1
gene id: 9483:CCR1
uniprot id: Q9MYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:LOC100389093
gene id: 9483:LOC100389093
uniprot id: B0VXB5
uniprot id: Q9GJS7
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
messages: Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).
messages: Red blood cells.

9483:ZHX3
gene id: 9483:ZHX3
uniprot id: F6QSD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9483:HSCB
gene id: 9483:HSCB
uniprot id: A0A2R8M6R9
uniprot id: A0A8I3WPU2
names: Similarity
messages: Belongs to the HscB family.

9483:PSMA1
gene id: 9483:PSMA1
uniprot id: F7GW13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:ADIPOR2
gene id: 9483:ADIPOR2
uniprot id: F6UC87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9483:GJC2
gene id: 9483:GJC2
uniprot id: F7H2L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:DIPK2B
gene id: 9483:DIPK2B
uniprot id: F7ISG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9483:DPT
gene id: 9483:DPT
uniprot id: U3E618
names: Similarity
messages: Belongs to the dermatopontin family.

9483:TPPP2
gene id: 9483:TPPP2
uniprot id: F7IA21
names: Similarity
messages: Belongs to the TPPP family.

9483:CTSC
gene id: 9483:CTSC
uniprot id: U3CIA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9483:EXO5
gene id: 9483:EXO5
uniprot id: F6TP17
names: Similarity
messages: Belongs to the EXO5 family.

9483:MRPS24
gene id: 9483:MRPS24
uniprot id: U3CV92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

9483:MYH9
gene id: 9483:MYH9
uniprot id: F6ZZ90
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:DSCC1
gene id: 9483:DSCC1
uniprot id: F6YTT6
names: Similarity
messages: Belongs to the DCC1 family.

9483:CD82
gene id: 9483:CD82
uniprot id: U3CCW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:LIN9
gene id: 9483:LIN9
uniprot id: F7II53
uniprot id: U3DP36
names: Similarity
messages: Belongs to the lin-9 family.

9483:LOC100397654
gene id: 9483:LOC100397654
uniprot id: F7FZ33
uniprot id: U3DMU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9483:ELAC2
gene id: 9483:ELAC2
uniprot id: U3FAR9
names: Similarity
messages: Belongs to the RNase Z family.

9483:NTN4
gene id: 9483:NTN4
uniprot id: F6UDK1
uniprot id: U3CXF1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:AMPD1
gene id: 9483:AMPD1
uniprot id: F7I5U7
uniprot id: F7I851
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

9483:PFN2
gene id: 9483:PFN2
uniprot id: U3BGM3
uniprot id: U3CT70
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

9483:IL4R
gene id: 9483:IL4R
uniprot id: Q0PIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

9483:LOC100405000
gene id: 9483:LOC100405000
uniprot id: F6RXN0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9483:SCGB1D1
gene id: 9483:SCGB1D1
uniprot id: U3B870
names: Subcellular Location Annotation
messages: Secreted

9483:NXF1
gene id: 9483:NXF1
uniprot id: F7ABX7
uniprot id: U3DVC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

9483:L3MBTL4
gene id: 9483:L3MBTL4
uniprot id: F7C236
names: Subcellular Location Annotation
messages: Nucleus

9483:PCSK2
gene id: 9483:PCSK2
uniprot id: U3CJ12
uniprot id: U3FAE0
names: Similarity
messages: Belongs to the peptidase S8 family.

9483:DEFB104B
gene id: 9483:DEFB104B
uniprot id: A8CYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:MCU
gene id: 9483:MCU
uniprot id: F6WI22
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9483:GPX4
gene id: 9483:GPX4
uniprot id: Q32QL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutathione peroxidase family.
messages: Cytoplasm
messages: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).
messages: Expressed in testis. Also expressed in liver, lung, kidney and spinal cord.
messages: Mitochondrion
messages: Monomer. Has a tendency to form higher mass oligomers.

9483:SMC4
gene id: 9483:SMC4
uniprot id: A0A8I3ZZA5
uniprot id: F7HS45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

9483:NRN1L
gene id: 9483:NRN1L
uniprot id: F7I5C5
names: Similarity
messages: Belongs to the neuritin family.

9483:LOC100407433
gene id: 9483:LOC100407433
uniprot id: F6RAS1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:FAM167B
gene id: 9483:FAM167B
uniprot id: F6QAE5
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9483:LOC100410987
gene id: 9483:LOC100410987
uniprot id: U3FT46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9483:LRWD1
gene id: 9483:LRWD1
uniprot id: F7HKM2
uniprot id: U3EMU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRWD1 family.
messages: centrosome
messages: kinetochore
messages: telomere

9483:PLIN2
gene id: 9483:PLIN2
uniprot id: A0A8I3WQ03
names: Similarity
messages: Belongs to the perilipin family.

9483:GPR50
gene id: 9483:GPR50
uniprot id: A0A5F4VW19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:KCNK13
gene id: 9483:KCNK13
uniprot id: A0A5F4WKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9483:DHX9
gene id: 9483:DHX9
uniprot id: F7I8T9
uniprot id: U3CWY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

9483:SNRPD2
gene id: 9483:SNRPD2
uniprot id: U3E603
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

9483:MOCS2
gene id: 9483:MOCS2
uniprot id: A0A5F4W305
uniprot id: F7IBH5
uniprot id: U3ECX2
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
messages: Belongs to the MoaD family. MOCS2A subfamily.
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B) from an overlapping reading frame.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9483:UNC50
gene id: 9483:UNC50
uniprot id: U3FGA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

9483:S100Z
gene id: 9483:S100Z
uniprot id: A0A8I3WFT9
names: Similarity
messages: Belongs to the S-100 family.

9483:TMEM138
gene id: 9483:TMEM138
uniprot id: F7HCV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9483:MTIF2
gene id: 9483:MTIF2
uniprot id: A0A8J8YR64
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

9483:SLC25A37
gene id: 9483:SLC25A37
uniprot id: U3C4C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:CNOT7
gene id: 9483:CNOT7
uniprot id: F6QE98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9483:PPIL2
gene id: 9483:PPIL2
uniprot id: U3FA41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9483:NCDN
gene id: 9483:NCDN
uniprot id: U3BUT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9483:GBGT1
gene id: 9483:GBGT1
uniprot id: F6R2J3
uniprot id: F7H240
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

9483:AIMP2
gene id: 9483:AIMP2
uniprot id: F7C5F2
uniprot id: U3FIK2
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9483:WWP1
gene id: 9483:WWP1
uniprot id: F7GXT3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RBKS
gene id: 9483:RBKS
uniprot id: F7H3K8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

9483:AQP10
gene id: 9483:AQP10
uniprot id: A0A2R8P539
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:TLR5
gene id: 9483:TLR5
uniprot id: A0A5F4WCT5
uniprot id: F7HV85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9483:LOC100399525
gene id: 9483:LOC100399525
uniprot id: F7HZW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:COR51P3
gene id: 9483:COR51P3
uniprot id: B0VXA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:FAM120B
gene id: 9483:FAM120B
uniprot id: A0A8I3W7S6
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9483:LOC100393317
gene id: 9483:LOC100393317
uniprot id: F7CCF9
names: Similarity
messages: Belongs to the CLCR family.

9483:FTH1
gene id: 9483:FTH1
uniprot id: A0A2R8P242
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9483:PTPRT
gene id: 9483:PTPRT
uniprot id: U3BNL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9483:PON2
gene id: 9483:PON2
uniprot id: F7D0R7
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9483:RFX3
gene id: 9483:RFX3
uniprot id: F7ESI7
names: Subcellular Location Annotation
messages: Nucleus

9483:TCTEX1D1
gene id: 9483:TCTEX1D1
uniprot id: F7I7T4
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9483:GCSH
gene id: 9483:GCSH
uniprot id: U3CM87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9483:CARMIL3
gene id: 9483:CARMIL3
uniprot id: F7BFA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9483:TRPC3
gene id: 9483:TRPC3
uniprot id: U3FM83
names: Subcellular Location Annotation
messages: Membrane

9483:IDNK
gene id: 9483:IDNK
uniprot id: F7F3U9
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

9483:OTOP2
gene id: 9483:OTOP2
uniprot id: F7FFL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9483:KCNS3
gene id: 9483:KCNS3
uniprot id: F7AEV5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:ERC1
gene id: 9483:ERC1
uniprot id: A0A2R8M4H6
uniprot id: A0A2R8MF14
uniprot id: A0A5K1UVS9
uniprot id: F6VIX1
names: Subcellular Location Annotation
messages: Cytoplasm

9483:PEX19
gene id: 9483:PEX19
uniprot id: F7HYX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9483:PIP4P1
gene id: 9483:PIP4P1
uniprot id: F7I551
uniprot id: U3FEW4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9483:CRIPT
gene id: 9483:CRIPT
uniprot id: F6UYR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

9483:ACTR5
gene id: 9483:ACTR5
uniprot id: U3BGR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP5 subfamily.
messages: Nucleus

9483:SCD
gene id: 9483:SCD
uniprot id: U3DJ56
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9483:KRT17
gene id: 9483:KRT17
uniprot id: F7ANB4
names: Similarity
messages: Belongs to the intermediate filament family.

9483:ELF2
gene id: 9483:ELF2
uniprot id: A0A5K1UTA1
uniprot id: F7ECT1
uniprot id: F7HVP3
uniprot id: F7HVP8
uniprot id: U3EME5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:TSPAN14
gene id: 9483:TSPAN14
uniprot id: U3DH67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:UBE2A
gene id: 9483:UBE2A
uniprot id: F6SPE3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:RAB39B
gene id: 9483:RAB39B
uniprot id: B0KWV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9483:LOC100404555
gene id: 9483:LOC100404555
uniprot id: F7ID46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:RELT
gene id: 9483:RELT
uniprot id: F7I7U0
names: Similarity
messages: Belongs to the RELT family.

9483:LDLRAD4
gene id: 9483:LDLRAD4
uniprot id: F7EFE9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:LSM14B
gene id: 9483:LSM14B
uniprot id: U3EZ15
names: Similarity
messages: Belongs to the LSM14 family.

9483:RTEL1
gene id: 9483:RTEL1
uniprot id: U3CLK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Interacts with TERF1. Interacts (via PIP-box) with PCNA; the interaction is direct and essential for suppressing telomere fragility. Interacts with MMS19; the interaction mediates the association of RTEL1 with the cytosolic iron-sulfur protein assembly (CIA) complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:SQSTM1
gene id: 9483:SQSTM1
uniprot id: F7G7S9
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9483:DDX18
gene id: 9483:DDX18
uniprot id: U3F396
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

9483:TRIM56
gene id: 9483:TRIM56
uniprot id: F7I5G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9483:MRPS16
gene id: 9483:MRPS16
uniprot id: F7GYM4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9483:CSK
gene id: 9483:CSK
uniprot id: F6QS08
uniprot id: U3BXQ3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:PRKCI
gene id: 9483:PRKCI
uniprot id: U3FID0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9483:SCPEP1
gene id: 9483:SCPEP1
uniprot id: F6XR88
uniprot id: U3FPI9
names: Similarity
messages: Belongs to the peptidase S10 family.

9483:MTCH2
gene id: 9483:MTCH2
uniprot id: F6VE72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:ARL6IP4
gene id: 9483:ARL6IP4
uniprot id: F6Y6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: nucleolus

9483:MRPS23
gene id: 9483:MRPS23
uniprot id: F6VXA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

9483:LOC100409740
gene id: 9483:LOC100409740
uniprot id: A0A8I4A680
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:ND4L
gene id: 9483:ND4L
uniprot id: E1CJB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9483:NFIA
gene id: 9483:NFIA
uniprot id: A0A2R8M331
uniprot id: A0A8I3WQB5
uniprot id: F7I543
uniprot id: F7I549
uniprot id: F7I562
uniprot id: U3CME0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9483:JOSD2
gene id: 9483:JOSD2
uniprot id: U3DD69
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PLSCR1
gene id: 9483:PLSCR1
uniprot id: U3APV7
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9483:SF3B3
gene id: 9483:SF3B3
uniprot id: U3CQS7
names: Subcellular Location Annotation
messages: Nucleus

9483:BIRC7
gene id: 9483:BIRC7
uniprot id: F7ERH0
names: Similarity
messages: Belongs to the IAP family.

9483:FOXN2
gene id: 9483:FOXN2
uniprot id: F7IK91
uniprot id: U3EET7
names: Subcellular Location Annotation
messages: Nucleus

9483:PHACTR2
gene id: 9483:PHACTR2
uniprot id: A0A2R8MAG7
uniprot id: A0A2R8PK56
uniprot id: F7HI08
uniprot id: F7HI64
uniprot id: U3DFP6
uniprot id: U3DHU4
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9483:KCNK2
gene id: 9483:KCNK2
uniprot id: A0A8I3WU10
uniprot id: F6UI26
uniprot id: F6UIJ9
uniprot id: U3EGJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9483:KIF11
gene id: 9483:KIF11
uniprot id: A0A2R8N4A4
uniprot id: A0A8I3WQI2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:RPS27
gene id: 9483:RPS27
uniprot id: B0VXF6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:LITAF
gene id: 9483:LITAF
uniprot id: U3BJG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9483:RNF13
gene id: 9483:RNF13
uniprot id: F7HBJ4
names: Subcellular Location Annotation
messages: Membrane

9483:RPS5
gene id: 9483:RPS5
uniprot id: F6T2T8
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9483:GTF2E1
gene id: 9483:GTF2E1
uniprot id: F7GNV1
uniprot id: U3EL39
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

9483:CCR2
gene id: 9483:CCR2
uniprot id: F7DT70
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:CCL11
gene id: 9483:CCL11
uniprot id: F7I909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:SUB1
gene id: 9483:SUB1
uniprot id: F7I1C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9483:C1H9orf64
gene id: 9483:C1H9orf64
uniprot id: A0A8I3W0E7
uniprot id: F7EBM2
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

9483:MMUT
gene id: 9483:MMUT
uniprot id: A0A2R8MCH4
uniprot id: A0A2R8PLD0
uniprot id: F6QPW2
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

9483:RPS25
gene id: 9483:RPS25
uniprot id: F7AIV0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

9483:BCKDHA
gene id: 9483:BCKDHA
uniprot id: F6XSY5
uniprot id: U3DKQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

9483:HNRNPK
gene id: 9483:HNRNPK
uniprot id: F7IK44
uniprot id: U3CKT0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9483:RASGRP4
gene id: 9483:RASGRP4
uniprot id: F6VJ95
names: Similarity
messages: Belongs to the RASGRP family.

9483:SLC24A4
gene id: 9483:SLC24A4
uniprot id: F6PIT7
uniprot id: U3D277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9483:NSF
gene id: 9483:NSF
uniprot id: U3CRA9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9483:YPEL2
gene id: 9483:YPEL2
uniprot id: U3CVF8
names: Similarity
messages: Belongs to the yippee family.

9483:NCAPG
gene id: 9483:NCAPG
uniprot id: F7GVY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9483:GIPR
gene id: 9483:GIPR
uniprot id: F6Y4K4
names: Subcellular Location Annotation
messages: Membrane

9483:ATXN1L
gene id: 9483:ATXN1L
uniprot id: F6RTB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9483:PNKD
gene id: 9483:PNKD
uniprot id: F6YQM1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9483:PM20D2
gene id: 9483:PM20D2
uniprot id: F6XUF6
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

9483:H2AFV
gene id: 9483:H2AFV
uniprot id: A0A2R8M9S5
uniprot id: A0A2R8P821
uniprot id: U3DUR7
uniprot id: U3EEU6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:NLE1
gene id: 9483:NLE1
uniprot id: F7GHQ8
names: Subcellular Location Annotation
messages: nucleolus

9483:ENPEP
gene id: 9483:ENPEP
uniprot id: F7EVP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

9483:STAM2
gene id: 9483:STAM2
uniprot id: U3ET33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9483:IL4I1
gene id: 9483:IL4I1
uniprot id: U3DQ35
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9483:NLGN3
gene id: 9483:NLGN3
uniprot id: F7DYQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9483:PPP4R2
gene id: 9483:PPP4R2
uniprot id: U3D0Z9
names: Similarity
messages: Belongs to the PPP4R2 family.

9483:CCDC25
gene id: 9483:CCDC25
uniprot id: A0A5F4W7J6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9483:LBR
gene id: 9483:LBR
uniprot id: A0A8I3W699
uniprot id: A0A8I3WE83
uniprot id: F7ID33
uniprot id: U3BM96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9483:LOXL4
gene id: 9483:LOXL4
uniprot id: F7IRX7
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9483:SLC13A4
gene id: 9483:SLC13A4
uniprot id: U3E7C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9483:BRINP3
gene id: 9483:BRINP3
uniprot id: F7I8S2
names: Similarity
messages: Belongs to the BRINP family.

9483:ZSCAN9
gene id: 9483:ZSCAN9
uniprot id: U3CI98
names: Subcellular Location Annotation
messages: Nucleus

9483:EI24
gene id: 9483:EI24
uniprot id: F7GUJ0
uniprot id: U3FHJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

9483:PROKR1
gene id: 9483:PROKR1
uniprot id: F7ISJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:ST14
gene id: 9483:ST14
uniprot id: U3FUA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Degrades extracellular matrix.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:RTF2
gene id: 9483:RTF2
uniprot id: F7I571
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9483:TOB2
gene id: 9483:TOB2
uniprot id: F7HNT3
names: Similarity
messages: Belongs to the BTG family.

9483:CGA
gene id: 9483:CGA
uniprot id: A0A5K1VJ21
uniprot id: P51499
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Heterodimer. The active hormones thyrotropin, lutropin, follitropin and choriogonadotropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin, FSHB for follitropin and choriogonadotropin subunit beta/CGB for choriogonadotropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9483:NPB
gene id: 9483:NPB
uniprot id: F6QBS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

9483:CCDC58
gene id: 9483:CCDC58
uniprot id: F7GIH3
names: Similarity
messages: Belongs to the MIX23 family.

9483:UBE2D4
gene id: 9483:UBE2D4
uniprot id: F6QG68
uniprot id: F7I4I7
uniprot id: U3E9V5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:PTMA
gene id: 9483:PTMA
uniprot id: A0A8I3WRE3
uniprot id: U3FCQ0
names: Similarity
messages: Belongs to the pro/parathymosin family.

9483:VPS37A
gene id: 9483:VPS37A
uniprot id: U3CKF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9483:AOC1
gene id: 9483:AOC1
uniprot id: F7CDQ6
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9483:B3GALT2
gene id: 9483:B3GALT2
uniprot id: F7DSY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:WNT2
gene id: 9483:WNT2
uniprot id: Q2QLG1
uniprot id: U3E233
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

9483:C12H16orf72
gene id: 9483:C12H16orf72
uniprot id: F7IJL5
names: Similarity
messages: Belongs to the TAPR1 family.

9483:PRPH2
gene id: 9483:PRPH2
uniprot id: F7HZ28
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

9483:THEMIS
gene id: 9483:THEMIS
uniprot id: A0A8I3WY64
names: Similarity
messages: Belongs to the themis family.

9483:POMT1
gene id: 9483:POMT1
uniprot id: U3DBJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9483:SMIM22
gene id: 9483:SMIM22
uniprot id: A0A2R8MYT8
names: Subcellular Location Annotation
messages: Membrane

9483:GDPD1
gene id: 9483:GDPD1
uniprot id: A0A5F4WCD7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9483:XPR1
gene id: 9483:XPR1
uniprot id: U3C4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

9483:TLCD4
gene id: 9483:TLCD4
uniprot id: U3CVH9
names: Subcellular Location Annotation
messages: Membrane

9483:TENT5B
gene id: 9483:TENT5B
uniprot id: U3D7K2
names: Similarity
messages: Belongs to the TENT family.

9483:LYRM7
gene id: 9483:LYRM7
uniprot id: F7IQS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9483:SGMS1
gene id: 9483:SGMS1
uniprot id: A0A2R8MTY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9483:IFNGR1
gene id: 9483:IFNGR1
uniprot id: U3FIJ0
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9483:TGM3
gene id: 9483:TGM3
uniprot id: F7IIF1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9483:EIF2S2
gene id: 9483:EIF2S2
uniprot id: F6SFK4
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9483:DEFB134
gene id: 9483:DEFB134
uniprot id: A0A8I3WYR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:GLUD1
gene id: 9483:GLUD1
uniprot id: U3C0I9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

9483:EDA2R
gene id: 9483:EDA2R
uniprot id: A0A5K1UF15
uniprot id: A0A8J8YCF7
uniprot id: F7FHA0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RAB3A
gene id: 9483:RAB3A
uniprot id: F6WFR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9483:CXXC5
gene id: 9483:CXXC5
uniprot id: U3FQ54
names: Subcellular Location Annotation
messages: Cytoplasm

9483:MPP6
gene id: 9483:MPP6
uniprot id: F6ZVZ4
uniprot id: U3DTF2
names: Similarity
messages: Belongs to the MAGUK family.

9483:ZNF687
gene id: 9483:ZNF687
uniprot id: B0KWC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9483:SCML4
gene id: 9483:SCML4
uniprot id: F7IQE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9483:JUNB
gene id: 9483:JUNB
uniprot id: A0A8I4A422
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9483:ATP6V1G2
gene id: 9483:ATP6V1G2
uniprot id: F7IEI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9483:SMAD5
gene id: 9483:SMAD5
uniprot id: U3FCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9483:NSUN5
gene id: 9483:NSUN5
uniprot id: U3FK60
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9483:CERS6
gene id: 9483:CERS6
uniprot id: F7I442
uniprot id: F7I6G2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9483:MGAT1
gene id: 9483:MGAT1
uniprot id: F7I3E4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9483:ASB17
gene id: 9483:ASB17
uniprot id: F6QB97
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9483:CPSF6
gene id: 9483:CPSF6
uniprot id: F7GPL3
uniprot id: F7GUT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Cytoplasm
messages: Nucleus speckle
messages: nucleoplasm

9483:CEP44
gene id: 9483:CEP44
uniprot id: A0A5F4W0M4
uniprot id: A0A5F4WK08
uniprot id: U3EKX5
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9483:HOXB7
gene id: 9483:HOXB7
uniprot id: F7AVK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:SEH1L
gene id: 9483:SEH1L
uniprot id: F7EUR5
uniprot id: U3CY94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9483:APPL2
gene id: 9483:APPL2
uniprot id: U3BC20
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9483:ADGRB3
gene id: 9483:ADGRB3
uniprot id: U3DYQ3
names: Subcellular Location Annotation
messages: Membrane

9483:EPHB1
gene id: 9483:EPHB1
uniprot id: U3EWE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9483:PRORP
gene id: 9483:PRORP
uniprot id: F7EHE5
names: Similarity
messages: Belongs to the PPR family. P subfamily.

9483:KCNS1
gene id: 9483:KCNS1
uniprot id: F7FJE7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:CACNB4
gene id: 9483:CACNB4
uniprot id: F7GGT8
uniprot id: U3D4S4
uniprot id: U3EX85
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9483:LOC100411008
gene id: 9483:LOC100411008
uniprot id: F7HQH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9483:ILK
gene id: 9483:ILK
uniprot id: F6WGW3
uniprot id: F7DKL4
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9483:RPS21
gene id: 9483:RPS21
uniprot id: F7IE69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9483:ARG1
gene id: 9483:ARG1
uniprot id: A0A5F4WCM4
names: Similarity
messages: Belongs to the arginase family.

9483:AASDH
gene id: 9483:AASDH
uniprot id: A0A8I3X0Z9
uniprot id: F6QFB5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:YOD1
gene id: 9483:YOD1
uniprot id: F7CPY9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9483:NCK2
gene id: 9483:NCK2
uniprot id: F7HUY1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9483:ESS2
gene id: 9483:ESS2
uniprot id: U3CKQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

9483:SMUG1
gene id: 9483:SMUG1
uniprot id: F7I3E6
uniprot id: F7I3E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9483:LHPP
gene id: 9483:LHPP
uniprot id: U3D175
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9483:LOC100412773
gene id: 9483:LOC100412773
uniprot id: A0A8I3X205
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SLC13A3
gene id: 9483:SLC13A3
uniprot id: U3F1K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9483:HTR6
gene id: 9483:HTR6
uniprot id: A0A5F4VZZ9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:VPS33B
gene id: 9483:VPS33B
uniprot id: F7IRH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9483:MPG
gene id: 9483:MPG
uniprot id: A0A2R8MF92
uniprot id: F6QTA1
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

9483:PIGV
gene id: 9483:PIGV
uniprot id: U3DAR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9483:ERMN
gene id: 9483:ERMN
uniprot id: A0A8I3WEY0
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9483:IRF7
gene id: 9483:IRF7
uniprot id: U3BP84
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:MOB2
gene id: 9483:MOB2
uniprot id: U3CXE9
names: Similarity
messages: Belongs to the MOB1/phocein family.

9483:PIGM
gene id: 9483:PIGM
uniprot id: F7HX28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9483:RXRA
gene id: 9483:RXRA
uniprot id: U3F0V7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9483:SLC6A15
gene id: 9483:SLC6A15
uniprot id: U3EDL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

9483:NR2C2
gene id: 9483:NR2C2
uniprot id: A0A2R8NC69
uniprot id: F7IHE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9483:HSD3B7
gene id: 9483:HSD3B7
uniprot id: F7ILT9
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9483:SDC2
gene id: 9483:SDC2
uniprot id: F7IT99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9483:RORB
gene id: 9483:RORB
uniprot id: F7IE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:PFAS
gene id: 9483:PFAS
uniprot id: F7HZR0
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

9483:BAMBI
gene id: 9483:BAMBI
uniprot id: F7GN88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9483:TATDN3
gene id: 9483:TATDN3
uniprot id: F7IRW0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9483:CASQ1
gene id: 9483:CASQ1
uniprot id: A0A8I3WPH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9483:PSME4
gene id: 9483:PSME4
uniprot id: A0A8I3VY39
uniprot id: F7A030
uniprot id: U3BKW6
names: Similarity
messages: Belongs to the BLM10 family.

9483:LOC103788005
gene id: 9483:LOC103788005
uniprot id: A0A8I3WH84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9483:VTI1B
gene id: 9483:VTI1B
uniprot id: F7AQT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9483:ATL1
gene id: 9483:ATL1
uniprot id: U3CKC1
uniprot id: U3EKI1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9483:KHDC3L
gene id: 9483:KHDC3L
uniprot id: U3DJS3
names: Similarity
messages: Belongs to the KHDC1 family.

9483:RDH14
gene id: 9483:RDH14
uniprot id: F7AE01
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:ARL6
gene id: 9483:ARL6
uniprot id: U3EQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9483:SORL1
gene id: 9483:SORL1
uniprot id: U3F3R1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9483:WNT3A
gene id: 9483:WNT3A
uniprot id: A0A5F4W3S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:ZDHHC4
gene id: 9483:ZDHHC4
uniprot id: F6Z4M3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:NXPE3
gene id: 9483:NXPE3
uniprot id: U3DW86
names: Similarity
messages: Belongs to the NXPE family.

9483:CAPZA2
gene id: 9483:CAPZA2
uniprot id: Q2QLG4
uniprot id: U3DUR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity).

9483:OR10G3
gene id: 9483:OR10G3
uniprot id: F7G5T7
names: Subcellular Location Annotation
messages: Membrane

9483:STAG3
gene id: 9483:STAG3
uniprot id: F6WTL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9483:KCNJ2
gene id: 9483:KCNJ2
uniprot id: F6W2Q8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking.
messages: Membrane

9483:RNF141
gene id: 9483:RNF141
uniprot id: F7GRH4
names: Function
messages: May be involved in spermatogenesis.

9483:SNX4
gene id: 9483:SNX4
uniprot id: U3DS06
names: Similarity
messages: Belongs to the sorting nexin family.

9483:ESR1
gene id: 9483:ESR1
uniprot id: F7FPN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

9483:TRAF2
gene id: 9483:TRAF2
uniprot id: U3B0E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9483:ALDH9A1
gene id: 9483:ALDH9A1
uniprot id: U3CQG4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:FOXS1
gene id: 9483:FOXS1
uniprot id: F7ELQ3
names: Subcellular Location Annotation
messages: Nucleus

9483:PRKACB
gene id: 9483:PRKACB
uniprot id: A0A2R8MZJ8
uniprot id: A0A8I3WBJ8
uniprot id: F6SLA1
uniprot id: F7FX16
uniprot id: F7I3D0
uniprot id: F7IA24
uniprot id: F7IAR6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

9483:DZIP3
gene id: 9483:DZIP3
uniprot id: F7HI26
names: Subcellular Location Annotation
messages: Cytoplasm

9483:IL1F10
gene id: 9483:IL1F10
uniprot id: F7CCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9483:HSPB2
gene id: 9483:HSPB2
uniprot id: F6ZR37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

9483:SORCS1
gene id: 9483:SORCS1
uniprot id: U3FTT8
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9483:GSTM3
gene id: 9483:GSTM3
uniprot id: F6TIC3
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9483:PEX7
gene id: 9483:PEX7
uniprot id: A0A2R8MWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

9483:ARPC5
gene id: 9483:ARPC5
uniprot id: U3DZB7
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9483:KLHL36
gene id: 9483:KLHL36
uniprot id: U3DQ31
names: Function
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9483:GNAZ
gene id: 9483:GNAZ
uniprot id: F7I574
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

9483:TMEM242
gene id: 9483:TMEM242
uniprot id: F7G9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9483:MTRF1
gene id: 9483:MTRF1
uniprot id: F7GQR3
uniprot id: U3ELP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9483:IPO4
gene id: 9483:IPO4
uniprot id: U3ESP2
names: Subcellular Location Annotation
messages: Cytoplasm

9483:TFB1M
gene id: 9483:TFB1M
uniprot id: U3FDQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

9483:PAM16
gene id: 9483:PAM16
uniprot id: U3BYV6
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

9483:RGS1
gene id: 9483:RGS1
uniprot id: F6Y6A3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

9483:LOC100405150
gene id: 9483:LOC100405150
uniprot id: A0A5F4W2C9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9483:CCNQ
gene id: 9483:CCNQ
uniprot id: A0A8J8XV73
uniprot id: F7GVF7
names: Similarity
messages: Belongs to the cyclin family. Cyclin-like FAM58 subfamily.

9483:SUGP2
gene id: 9483:SUGP2
uniprot id: F6SZK4
uniprot id: U3DDJ7
names: Subcellular Location Annotation
messages: Nucleus

9483:DNM1L
gene id: 9483:DNM1L
uniprot id: A0A2R8MVS5
uniprot id: F6Q1Q2
uniprot id: F6SIE1
uniprot id: F6TQ78
uniprot id: F6U0L1
uniprot id: U3BXM6
uniprot id: U3FH93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

9483:PRPS1
gene id: 9483:PRPS1
uniprot id: F7HZU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9483:SPACA4
gene id: 9483:SPACA4
uniprot id: A0A5F4W347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9483:HMBS
gene id: 9483:HMBS
uniprot id: F6XT45
uniprot id: U3FF00
names: Similarity
messages: Belongs to the HMBS family.

9483:RHAG
gene id: 9483:RHAG
uniprot id: F6TSA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9483:IPMK
gene id: 9483:IPMK
uniprot id: F6SSU3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9483:SERBP1
gene id: 9483:SERBP1
uniprot id: A0A8I3W1Q6
uniprot id: F7EEX7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:CCNG2
gene id: 9483:CCNG2
uniprot id: F6VUX7
names: Similarity
messages: Belongs to the cyclin family.

9483:LOC100387518
gene id: 9483:LOC100387518
uniprot id: A0A2R8P242
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9483:CYP7A1
gene id: 9483:CYP7A1
uniprot id: F7HJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9483:MAPK1IP1L
gene id: 9483:MAPK1IP1L
uniprot id: F6QMV7
names: Similarity
messages: Belongs to the MISS family.

9483:BTAF1
gene id: 9483:BTAF1
uniprot id: A0A2R8MUK8
uniprot id: F7H9R4
names: Subcellular Location Annotation
messages: Nucleus

9483:FMO4
gene id: 9483:FMO4
uniprot id: F7I9S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9483:NDUFB7
gene id: 9483:NDUFB7
uniprot id: F7HN05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9483:PPIL3
gene id: 9483:PPIL3
uniprot id: F7IMM5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:CASD1
gene id: 9483:CASD1
uniprot id: A0A8I3VW25
uniprot id: A0A8I4A1B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9483:MTFR1
gene id: 9483:MTFR1
uniprot id: F7HYL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9483:TFPI2
gene id: 9483:TFPI2
uniprot id: U3ENJ1
names: Subcellular Location Annotation
messages: Secreted

9483:ITGB8
gene id: 9483:ITGB8
uniprot id: A0A8I3WN73
uniprot id: F7I2K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9483:TNFSF10
gene id: 9483:TNFSF10
uniprot id: F7E747
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9483:PPP6R2
gene id: 9483:PPP6R2
uniprot id: U3DCX6
names: Similarity
messages: Belongs to the SAPS family.

9483:CYP26B1
gene id: 9483:CYP26B1
uniprot id: F7GVB0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:ATG5
gene id: 9483:ATG5
uniprot id: A0A2R8M348
uniprot id: A0A2R8ML30
uniprot id: A0A8I3WPZ1
uniprot id: F7D5L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

9483:IMPACT
gene id: 9483:IMPACT
uniprot id: U3DNP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

9483:HDDC2
gene id: 9483:HDDC2
uniprot id: F7DG68
uniprot id: U3EQI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9483:PROM1
gene id: 9483:PROM1
uniprot id: A0A5F4W3J4
uniprot id: A0A5F4W6B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9483:EZH1
gene id: 9483:EZH1
uniprot id: U3EHI2
names: Subcellular Location Annotation
messages: Nucleus

9483:MIGA2
gene id: 9483:MIGA2
uniprot id: B0KWE8
names: Similarity
messages: Belongs to the mitoguardin family.

9483:GOT1
gene id: 9483:GOT1
uniprot id: F7GSG3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9483:LPL
gene id: 9483:LPL
uniprot id: F7HXL1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9483:VPS18
gene id: 9483:VPS18
uniprot id: F7IT14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9483:RPL24
gene id: 9483:RPL24
uniprot id: F6PN21
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9483:LOC100395175
gene id: 9483:LOC100395175
uniprot id: F7IDZ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:ATF1
gene id: 9483:ATF1
uniprot id: A0A2R8P9U0
names: Subcellular Location Annotation
messages: Nucleus

9483:PPP1R12B
gene id: 9483:PPP1R12B
uniprot id: U3CCN1
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9483:EXO1
gene id: 9483:EXO1
uniprot id: A0A5F4W6M1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9483:CROT
gene id: 9483:CROT
uniprot id: F7ENF8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9483:LXN
gene id: 9483:LXN
uniprot id: F6QAW6
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

9483:LAMC1
gene id: 9483:LAMC1
uniprot id: U3CXM9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9483:POLR1D
gene id: 9483:POLR1D
uniprot id: F7DLJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

9483:SCN3B
gene id: 9483:SCN3B
uniprot id: F7I734
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9483:ST6GAL1
gene id: 9483:ST6GAL1
uniprot id: F7I274
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:LOC100389598
gene id: 9483:LOC100389598
uniprot id: A0A8I3W4N9
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

9483:THNSL2
gene id: 9483:THNSL2
uniprot id: F6T1U5
uniprot id: U3AZV5
names: Similarity
messages: Belongs to the threonine synthase family.

9483:EMC6
gene id: 9483:EMC6
uniprot id: F6X896
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:PTGES2
gene id: 9483:PTGES2
uniprot id: F6XZ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

9483:PRKCH
gene id: 9483:PRKCH
uniprot id: F7HD36
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9483:LOC100388062
gene id: 9483:LOC100388062
uniprot id: U3F4I8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9483:PPP2R2D
gene id: 9483:PPP2R2D
uniprot id: A0A5F4WFA3
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9483:DUSP9
gene id: 9483:DUSP9
uniprot id: A0A8J8XJC0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9483:PF4
gene id: 9483:PF4
uniprot id: F6WJ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:FAM13B
gene id: 9483:FAM13B
uniprot id: F6XUV0
names: Similarity
messages: Belongs to the FAM13 family.

9483:SMG1
gene id: 9483:SMG1
uniprot id: F6S837
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9483:TNF
gene id: 9483:TNF
uniprot id: Q19LH4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9483:GIMAP7
gene id: 9483:GIMAP7
uniprot id: A0A8I3WYG6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9483:LOC100411801
gene id: 9483:LOC100411801
uniprot id: U3FSY9
names: Subcellular Location Annotation
messages: centrosome

9483:AHDC1
gene id: 9483:AHDC1
uniprot id: F7I0Z6
names: Subcellular Location Annotation
messages: Nucleus

9483:SEMA4F
gene id: 9483:SEMA4F
uniprot id: F7I7T5
uniprot id: F7IA44
uniprot id: U3BXV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CBL
gene id: 9483:CBL
uniprot id: F7CSE3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9483:PPP2CA
gene id: 9483:PPP2CA
uniprot id: F6XZ20
uniprot id: U3DKU0
names: Similarity
messages: Belongs to the PPP phosphatase family.

9483:LOC100411905
gene id: 9483:LOC100411905
uniprot id: H9KXP2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9483:CDK2
gene id: 9483:CDK2
uniprot id: F7BWH8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:EPS8L2
gene id: 9483:EPS8L2
uniprot id: U3CAB1
names: Similarity
messages: Belongs to the EPS8 family.

9483:HSD17B12
gene id: 9483:HSD17B12
uniprot id: F7DYP3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:NUP35
gene id: 9483:NUP35
uniprot id: U3EEJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

9483:SPON2
gene id: 9483:SPON2
uniprot id: U3BQU3
names: Subcellular Location Annotation
messages: extracellular matrix

9483:RGS9BP
gene id: 9483:RGS9BP
uniprot id: A0A8I3X174
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9483:BZW1
gene id: 9483:BZW1
uniprot id: A0A5F4WMG4
names: Similarity
messages: Belongs to the BZW family.

9483:TREX2
gene id: 9483:TREX2
uniprot id: F6SKZ6
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

9483:SSU72
gene id: 9483:SSU72
uniprot id: F7ETE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Nucleus
messages: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination.

9483:LOC108589623
gene id: 9483:LOC108589623
uniprot id: F7FDP2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

9483:THOC2
gene id: 9483:THOC2
uniprot id: B0KWH8
uniprot id: F7ESC3
uniprot id: U3CR12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A (By similarity).
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus
messages: Nucleus speckle
messages: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Plays a role for proper neuronal development.

9483:LOC100387786
gene id: 9483:LOC100387786
uniprot id: F7FTC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

9483:SLC25A51
gene id: 9483:SLC25A51
uniprot id: U3BCM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:GNG13
gene id: 9483:GNG13
uniprot id: A0A8I3X7B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:ARSG
gene id: 9483:ARSG
uniprot id: F7G1L1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9483:SAR1A
gene id: 9483:SAR1A
uniprot id: F6WCH0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9483:NDRG3
gene id: 9483:NDRG3
uniprot id: F6UR26
uniprot id: U3DPQ5
names: Similarity
messages: Belongs to the NDRG family.

9483:MRPS11
gene id: 9483:MRPS11
uniprot id: U3C3V6
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9483:UCK2
gene id: 9483:UCK2
uniprot id: F7IAY5
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.

9483:CCDC47
gene id: 9483:CCDC47
uniprot id: U3E5A3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Rough endoplasmic reticulum membrane

9483:APCS
gene id: 9483:APCS
uniprot id: F7I8N6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:SLC26A3
gene id: 9483:SLC26A3
uniprot id: F7BSM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Chloride/bicarbonate exchanger.
messages: Membrane

9483:DPY19L4
gene id: 9483:DPY19L4
uniprot id: A0A8I3VVX1
uniprot id: F7GYW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9483:SLC25A27
gene id: 9483:SLC25A27
uniprot id: A0A8I4A4E2
uniprot id: U3EW66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:MRPL33
gene id: 9483:MRPL33
uniprot id: U3CMP0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9483:PMVK
gene id: 9483:PMVK
uniprot id: F7IA91
names: Subcellular Location Annotation
messages: cytosol

9483:SIGMAR1
gene id: 9483:SIGMAR1
uniprot id: F6YPR0
uniprot id: U3DT67
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

9483:TLR1
gene id: 9483:TLR1
uniprot id: F6X7G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9483:C9H12orf65
gene id: 9483:C9H12orf65
uniprot id: F6Y5X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9483:RTN3
gene id: 9483:RTN3
uniprot id: F6WF07
uniprot id: U3EY57
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:CDYL
gene id: 9483:CDYL
uniprot id: F7H9N1
uniprot id: U3BH98
names: Subcellular Location Annotation
messages: Nucleus

9483:GPBP1L1
gene id: 9483:GPBP1L1
uniprot id: U3E0X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9483:SMARCD1
gene id: 9483:SMARCD1
uniprot id: F7FTP4
uniprot id: F7G3A0
names: Similarity
messages: Belongs to the SMARCD family.

9483:ALG3
gene id: 9483:ALG3
uniprot id: F6WW78
uniprot id: U3BKQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:LOC100411835
gene id: 9483:LOC100411835
uniprot id: A0A8I4A167
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9483:SUCLG2
gene id: 9483:SUCLG2
uniprot id: U3EK93
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9483:SLC26A4
gene id: 9483:SLC26A4
uniprot id: F6WCD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

9483:PKN2
gene id: 9483:PKN2
uniprot id: F7AVM1
uniprot id: F7I3Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

9483:SDR16C5
gene id: 9483:SDR16C5
uniprot id: F6W9K3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:PKNOX2
gene id: 9483:PKNOX2
uniprot id: F6Z692
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9483:HMGN1
gene id: 9483:HMGN1
uniprot id: F7II06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9483:LARS1
gene id: 9483:LARS1
uniprot id: U3D7F0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:CES4A
gene id: 9483:CES4A
uniprot id: F7A7N6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9483:ASIC2
gene id: 9483:ASIC2
uniprot id: F7I932
names: Subcellular Location Annotation
messages: Membrane

9483:CAPN6
gene id: 9483:CAPN6
uniprot id: U3AT41
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SBDS
gene id: 9483:SBDS
uniprot id: F6QRM2
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

9483:ATE1
gene id: 9483:ATE1
uniprot id: A0A5F4WFC8
uniprot id: A0A5F4WJK7
uniprot id: F7IL39
uniprot id: F7INE2
uniprot id: U3BHG0
uniprot id: U3C0E3
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9483:TFAP2D
gene id: 9483:TFAP2D
uniprot id: F6QSM7
names: Similarity
messages: Belongs to the AP-2 family.

9483:RAB39A
gene id: 9483:RAB39A
uniprot id: F7G8P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9483:SFRP5
gene id: 9483:SFRP5
uniprot id: F6ZL04
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SLC30A3
gene id: 9483:SLC30A3
uniprot id: F6XQY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9483:ELP4
gene id: 9483:ELP4
uniprot id: F7IDJ9
uniprot id: U3C5B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

9483:ERRFI1
gene id: 9483:ERRFI1
uniprot id: F7H303
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9483:P3H3
gene id: 9483:P3H3
uniprot id: U3CK44
names: Similarity
messages: Belongs to the leprecan family.

9483:RHOT1
gene id: 9483:RHOT1
uniprot id: A0A8J8XLS4
uniprot id: A0A8J8XUP8
uniprot id: A0A8J8XY62
uniprot id: F7I728
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9483:LOC100389231
gene id: 9483:LOC100389231
uniprot id: A0A8I3WIG8
uniprot id: F7IA32
names: Similarity
messages: Belongs to the MIF family.

9483:GLRA4
gene id: 9483:GLRA4
uniprot id: F6QEB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9483:KIF2A
gene id: 9483:KIF2A
uniprot id: A0A2R8MFK6
uniprot id: A0A2R8PKQ0
uniprot id: F6Z551
uniprot id: U3BC72
uniprot id: U3DRA9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:NEK8
gene id: 9483:NEK8
uniprot id: A0A8I3WJ52
uniprot id: F7D996
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9483:ITGA6
gene id: 9483:ITGA6
uniprot id: A0A5F4WAX0
uniprot id: F6XQ72
uniprot id: U3FDN1
uniprot id: U3FHX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9483:RAF1
gene id: 9483:RAF1
uniprot id: F7CJL2
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9483:XYLT2
gene id: 9483:XYLT2
uniprot id: U3FGH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

9483:POU1F1
gene id: 9483:POU1F1
uniprot id: F6ZPT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus

9483:PTGER4
gene id: 9483:PTGER4
uniprot id: F6VDJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9483:PGD
gene id: 9483:PGD
uniprot id: U3CWW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9483:SIM1
gene id: 9483:SIM1
uniprot id: F7HZQ9
names: Subcellular Location Annotation
messages: Nucleus

9483:MRPL2
gene id: 9483:MRPL2
uniprot id: F7H807
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9483:TAF6
gene id: 9483:TAF6
uniprot id: F7BUA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9483:EPHB3
gene id: 9483:EPHB3
uniprot id: F7G567
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100403703
gene id: 9483:LOC100403703
uniprot id: U3E603
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

9483:SLITRK3
gene id: 9483:SLITRK3
uniprot id: F7IJP7
names: Similarity
messages: Belongs to the SLITRK family.

9483:KCNG3
gene id: 9483:KCNG3
uniprot id: F7FFQ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:TMEM97
gene id: 9483:TMEM97
uniprot id: F7IFA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Endoplasmic reticulum membrane
messages: Interacts with NPC1.
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

9483:F13B
gene id: 9483:F13B
uniprot id: F7GPE8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LDB3
gene id: 9483:LDB3
uniprot id: U3BIJ7
names: Subcellular Location Annotation
messages: Z line

9483:TMEM151A
gene id: 9483:TMEM151A
uniprot id: F7IQK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

9483:BMP8A
gene id: 9483:BMP8A
uniprot id: F7IM63
names: Similarity
messages: Belongs to the TGF-beta family.

9483:FYN
gene id: 9483:FYN
uniprot id: F7IB43
uniprot id: U3BSY6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:MRPL35
gene id: 9483:MRPL35
uniprot id: F7H913
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

9483:MED26
gene id: 9483:MED26
uniprot id: F7CC97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

9483:DMAC2L
gene id: 9483:DMAC2L
uniprot id: F7HD94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion inner membrane

9483:GNPNAT1
gene id: 9483:GNPNAT1
uniprot id: F7CEE3
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9483:GPC6
gene id: 9483:GPC6
uniprot id: F7HKQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9483:SLC39A1
gene id: 9483:SLC39A1
uniprot id: U3BBV7
names: Subcellular Location Annotation
messages: Membrane

9483:ABHD3
gene id: 9483:ABHD3
uniprot id: F7I745
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9483:SMO
gene id: 9483:SMO
uniprot id: F7GPZ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:MBLAC1
gene id: 9483:MBLAC1
uniprot id: F7B5G6
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9483:MADD
gene id: 9483:MADD
uniprot id: F7E459
uniprot id: F7GT09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9483:CDK2AP2
gene id: 9483:CDK2AP2
uniprot id: F6ZYF1
names: Similarity
messages: Belongs to the CDK2AP family.

9483:CETN1
gene id: 9483:CETN1
uniprot id: A0A8I3W2T6
names: Similarity
messages: Belongs to the centrin family.

9483:SLC39A11
gene id: 9483:SLC39A11
uniprot id: A0A5K1V085
uniprot id: F6WNH0
names: Subcellular Location Annotation
messages: Membrane

9483:HOGA1
gene id: 9483:HOGA1
uniprot id: F7B5W8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9483:IDI1
gene id: 9483:IDI1
uniprot id: U3BH55
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

9483:HOXB13
gene id: 9483:HOXB13
uniprot id: F7BWB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9483:RARG
gene id: 9483:RARG
uniprot id: F6VV91
uniprot id: U3ENY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9483:SCNN1B
gene id: 9483:SCNN1B
uniprot id: U3B903
uniprot id: U3CVV7
names: Subcellular Location Annotation
messages: Membrane

9483:PLCB1
gene id: 9483:PLCB1
uniprot id: U3EKX0
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9483:PIGF
gene id: 9483:PIGF
uniprot id: F6UXU0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:ATP2A2
gene id: 9483:ATP2A2
uniprot id: A0A5F4WMB1
uniprot id: A0A8I3VZY4
uniprot id: U3FYJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9483:MPV17
gene id: 9483:MPV17
uniprot id: U3DV25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:TBL1X
gene id: 9483:TBL1X
uniprot id: A0A5F4W3X1
uniprot id: U3CNH4
names: Similarity
messages: Belongs to the WD repeat EBI family.

9483:TACR2
gene id: 9483:TACR2
uniprot id: A0A2R8MLH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LIPM
gene id: 9483:LIPM
uniprot id: A0A8I3WDX7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:ARPC5L
gene id: 9483:ARPC5L
uniprot id: U3DAD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: May be a component of the Arp2/3 complex in which it may replace ARPC5.
messages: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9483:IMMP2L
gene id: 9483:IMMP2L
uniprot id: U3AWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9483:HRH3
gene id: 9483:HRH3
uniprot id: U3DYG8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:XIAP
gene id: 9483:XIAP
uniprot id: B0KWH9
names: Similarity
messages: Belongs to the IAP family.

9483:AP5M1
gene id: 9483:AP5M1
uniprot id: U3DV88
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

9483:GJB7
gene id: 9483:GJB7
uniprot id: A0A654IEE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:ACY3
gene id: 9483:ACY3
uniprot id: U3EW25
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

9483:LOC103792212
gene id: 9483:LOC103792212
uniprot id: F7FGL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:USP4
gene id: 9483:USP4
uniprot id: F6TSE3
uniprot id: F6TSU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9483:L3HYPDH
gene id: 9483:L3HYPDH
uniprot id: F7IKN7
names: Similarity
messages: Belongs to the proline racemase family.

9483:WRNIP1
gene id: 9483:WRNIP1
uniprot id: F7D6S4
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

9483:PPP1R14D
gene id: 9483:PPP1R14D
uniprot id: F7ISZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9483:TAS2R41
gene id: 9483:TAS2R41
uniprot id: F7I726
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9483:LOC100394318
gene id: 9483:LOC100394318
uniprot id: F7HA47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9483:TM4SF19
gene id: 9483:TM4SF19
uniprot id: F6UJ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9483:LTA
gene id: 9483:LTA
uniprot id: A0A0U5JA93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9483:ABCB9
gene id: 9483:ABCB9
uniprot id: U3E6C0
names: Function
names: Subunit
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:HSPH1
gene id: 9483:HSPH1
uniprot id: F7HN07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9483:NUP93
gene id: 9483:NUP93
uniprot id: U3ERA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus envelope
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9483:UBE2E1
gene id: 9483:UBE2E1
uniprot id: U3F8V4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:KCNJ15
gene id: 9483:KCNJ15
uniprot id: F7ECR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9483:ATP6V1G1
gene id: 9483:ATP6V1G1
uniprot id: F6VKM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9483:ROMO1
gene id: 9483:ROMO1
uniprot id: B0KWM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9483:KDM4B
gene id: 9483:KDM4B
uniprot id: U3CZT0
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9483:POLD1
gene id: 9483:POLD1
uniprot id: F7ID43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9483:PRIM1
gene id: 9483:PRIM1
uniprot id: F6Y809
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9483:TSSK6
gene id: 9483:TSSK6
uniprot id: H9KXW8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:LOC103787193
gene id: 9483:LOC103787193
uniprot id: F7I990
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:LOC100391517
gene id: 9483:LOC100391517
uniprot id: F7DXB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

9483:LOC100400167
gene id: 9483:LOC100400167
uniprot id: F7FRP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LEF1
gene id: 9483:LEF1
uniprot id: A0A2R8MFA3
uniprot id: F7G9Z6
uniprot id: F7HYA2
uniprot id: F7I374
uniprot id: F7I5D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9483:HLF
gene id: 9483:HLF
uniprot id: A0A8I3WL88
uniprot id: F7FH72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9483:CCK
gene id: 9483:CCK
uniprot id: U3DR24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9483:VIPAS39
gene id: 9483:VIPAS39
uniprot id: F6VN50
uniprot id: U3DWP9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

9483:RAP2A
gene id: 9483:RAP2A
uniprot id: F6UKW7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9483:TAF6L
gene id: 9483:TAF6L
uniprot id: F7IFE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9483:GORASP2
gene id: 9483:GORASP2
uniprot id: F6Z4V2
names: Similarity
messages: Belongs to the GORASP family.

9483:NMI
gene id: 9483:NMI
uniprot id: F7HL49
uniprot id: U3BI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9483:ATP6V1B2
gene id: 9483:ATP6V1B2
uniprot id: A0A2R8MBE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9483:LOC100392213
gene id: 9483:LOC100392213
uniprot id: A0A5F4W2J6
uniprot id: F7HZP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9483:DNAJC22
gene id: 9483:DNAJC22
uniprot id: F7ISX1
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

9483:LOC100415219
gene id: 9483:LOC100415219
uniprot id: F7HEP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:NEMF
gene id: 9483:NEMF
uniprot id: U3CHM6
names: Similarity
messages: Belongs to the NEMF family.

9483:SERINC5
gene id: 9483:SERINC5
uniprot id: A0A2R8M3X6
uniprot id: U3E2A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

9483:NUP58
gene id: 9483:NUP58
uniprot id: U3EP89
names: Subcellular Location Annotation
messages: nuclear pore complex

9483:NXPH1
gene id: 9483:NXPH1
uniprot id: U3ERP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9483:SPTBN2
gene id: 9483:SPTBN2
uniprot id: U3DCT7
names: Similarity
messages: Belongs to the spectrin family.

9483:NDUFA5
gene id: 9483:NDUFA5
uniprot id: F7GKU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:LOC100399755
gene id: 9483:LOC100399755
uniprot id: Q95MG6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Phosphorylated on the C-terminal cytoplasmic tail.
messages: Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9483:SLC4A3
gene id: 9483:SLC4A3
uniprot id: U3DJY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9483:CLDN19
gene id: 9483:CLDN19
uniprot id: A0A2R8N099
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:CSTF1
gene id: 9483:CSTF1
uniprot id: F7GJ78
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100896450
gene id: 9483:LOC100896450
uniprot id: U3DYJ1
names: Subcellular Location Annotation
messages: Membrane

9483:LOC108589366
gene id: 9483:LOC108589366
uniprot id: A0A8I3X6J8
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9483:DLL4
gene id: 9483:DLL4
uniprot id: A0A2R8PCZ4
uniprot id: F7IT15
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9483:TRMT112
gene id: 9483:TRMT112
uniprot id: F6Q6G2
names: Similarity
messages: Belongs to the TRM112 family.

9483:CTNND1
gene id: 9483:CTNND1
uniprot id: A0A5K1TUV3
names: Similarity
messages: Belongs to the beta-catenin family.

9483:DBX2
gene id: 9483:DBX2
uniprot id: F7FPX6
uniprot id: U3CRZ0
names: Subcellular Location Annotation
messages: Nucleus

9483:GTF2H3
gene id: 9483:GTF2H3
uniprot id: U3CMZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

9483:ANKRD34A
gene id: 9483:ANKRD34A
uniprot id: U3FQ83
names: Similarity
messages: Belongs to the ANKRD34 family.

9483:DPPA5
gene id: 9483:DPPA5
uniprot id: F7G9E9
names: Similarity
messages: Belongs to the KHDC1 family.

9483:MEIS2
gene id: 9483:MEIS2
uniprot id: A0A2R8PDQ0
uniprot id: F7EAH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9483:CLUAP1
gene id: 9483:CLUAP1
uniprot id: A0A8J8XFW6
uniprot id: F7HDE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9483:SIN3A
gene id: 9483:SIN3A
uniprot id: F7A408
names: Subcellular Location Annotation
messages: Nucleus

9483:EVX1
gene id: 9483:EVX1
uniprot id: B0VXL0
names: Subcellular Location Annotation
messages: Nucleus

9483:CDK14
gene id: 9483:CDK14
uniprot id: A0A2R8MEH5
uniprot id: B0VXE8
uniprot id: F6VTH3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Found in a complex with LRP6, CCNY and CAPRIN2 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus. Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ.
messages: Nucleus
messages: Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A.
messages: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport (By similarity).

9483:HGD
gene id: 9483:HGD
uniprot id: F7DAA9
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9483:PSMD12
gene id: 9483:PSMD12
uniprot id: F6Y6C2
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9483:TERF2IP
gene id: 9483:TERF2IP
uniprot id: F7IEA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

9483:TMEM14C
gene id: 9483:TMEM14C
uniprot id: U3BQG5
names: Similarity
messages: Belongs to the TMEM14 family.

9483:TUBGCP4
gene id: 9483:TUBGCP4
uniprot id: A0A8I4A2B3
uniprot id: F7HYF3
uniprot id: U3BHN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9483:TMEM161B
gene id: 9483:TMEM161B
uniprot id: U3FR05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9483:F9
gene id: 9483:F9
uniprot id: A0A8I3W9Z9
uniprot id: F7DJ67
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:PLSCR5
gene id: 9483:PLSCR5
uniprot id: F7IQL8
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9483:MTMR12
gene id: 9483:MTMR12
uniprot id: A0A8I3XAX9
uniprot id: F7IAK7
uniprot id: U3EEE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Sarcoplasmic reticulum
messages: sarcomere

9483:SPIC
gene id: 9483:SPIC
uniprot id: F7HYR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:USP21
gene id: 9483:USP21
uniprot id: F7EUN1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:CEP57L1
gene id: 9483:CEP57L1
uniprot id: U3C9K5
names: Similarity
messages: Belongs to the translokin family.

9483:SNX21
gene id: 9483:SNX21
uniprot id: F7HVT2
uniprot id: F7HY46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9483:LOC100385920
gene id: 9483:LOC100385920
uniprot id: F6SRZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9483:DHRS11
gene id: 9483:DHRS11
uniprot id: U3CDC2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:CTNS
gene id: 9483:CTNS
uniprot id: F6YHX4
uniprot id: U3FGV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

9483:MFSD11
gene id: 9483:MFSD11
uniprot id: F6PYN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9483:SLC14A2
gene id: 9483:SLC14A2
uniprot id: F6PRG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9483:KDSR
gene id: 9483:KDSR
uniprot id: A0A5F4W9Q5
uniprot id: F7H8H1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:RPS12
gene id: 9483:RPS12
uniprot id: F7I360
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

9483:GCG
gene id: 9483:GCG
uniprot id: F7ID40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9483:HIBCH
gene id: 9483:HIBCH
uniprot id: A0A2R8MEB6
uniprot id: U3C1G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9483:PARP12
gene id: 9483:PARP12
uniprot id: F7F9E2
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:C10H15orf65
gene id: 9483:C10H15orf65
uniprot id: U3CVN2
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9483:HEXD
gene id: 9483:HEXD
uniprot id: F6SKY3
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

9483:XPO6
gene id: 9483:XPO6
uniprot id: F7HX34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9483:ZDHHC9
gene id: 9483:ZDHHC9
uniprot id: F7HP76
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:MED9
gene id: 9483:MED9
uniprot id: F7C678
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:COPS7A
gene id: 9483:COPS7A
uniprot id: U3DCD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9483:GLRA3
gene id: 9483:GLRA3
uniprot id: F7GC00
uniprot id: F7GLH0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9483:TAS2R8
gene id: 9483:TAS2R8
uniprot id: A0A8I3WVY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9483:ETS2
gene id: 9483:ETS2
uniprot id: F7IST1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:GUCY2D
gene id: 9483:GUCY2D
uniprot id: F7EAY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9483:BCO1
gene id: 9483:BCO1
uniprot id: A0A8I3WVM0
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9483:GCHFR
gene id: 9483:GCHFR
uniprot id: F7IKX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9483:TULP1
gene id: 9483:TULP1
uniprot id: F6VF34
uniprot id: F7C2M8
names: Similarity
messages: Belongs to the TUB family.

9483:CALHM4
gene id: 9483:CALHM4
uniprot id: F7HNE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9483:FOXP3
gene id: 9483:FOXP3
uniprot id: C7EPD6
names: Subcellular Location Annotation
messages: Nucleus

9483:PIP4P2
gene id: 9483:PIP4P2
uniprot id: A0A5F4WMQ6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9483:RIOK2
gene id: 9483:RIOK2
uniprot id: U3D1K8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9483:SEC24B
gene id: 9483:SEC24B
uniprot id: U3F0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9483:PDE5A
gene id: 9483:PDE5A
uniprot id: A0A2R8M2M9
uniprot id: A0A8I3X5J8
uniprot id: F7HKP9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:GABRR3
gene id: 9483:GABRR3
uniprot id: F7H4P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:AP1S2
gene id: 9483:AP1S2
uniprot id: A0A2R8PC25
uniprot id: A0A5F4VVK4
uniprot id: A0A8J8YRE4
uniprot id: F6Z8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9483:LOC100399393
gene id: 9483:LOC100399393
uniprot id: F7IRG6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9483:GDAP1
gene id: 9483:GDAP1
uniprot id: F6REU6
names: Similarity
messages: Belongs to the GST superfamily.

9483:UBP1
gene id: 9483:UBP1
uniprot id: A0A2R8M7A3
uniprot id: F6WEF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9483:OR6N2
gene id: 9483:OR6N2
uniprot id: F7HXL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:MRGPRD
gene id: 9483:MRGPRD
uniprot id: W8W3E7
names: Subcellular Location Annotation
messages: Cell membrane

9483:TYMS
gene id: 9483:TYMS
uniprot id: F7GTE7
names: Similarity
messages: Belongs to the thymidylate synthase family.

9483:ASH2L
gene id: 9483:ASH2L
uniprot id: F6RGV9
uniprot id: F6YKW9
uniprot id: U3E6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:GLRA2
gene id: 9483:GLRA2
uniprot id: F6PRK6
uniprot id: F6QPJ1
uniprot id: U3CG39
uniprot id: U3FXG3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9483:B3GALNT2
gene id: 9483:B3GALNT2
uniprot id: F6QG31
uniprot id: U3D6G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:TRIM2
gene id: 9483:TRIM2
uniprot id: U3DM64
uniprot id: U3F3S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9483:RPRM
gene id: 9483:RPRM
uniprot id: A0A2R8MZS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: Membrane

9483:CACNB2
gene id: 9483:CACNB2
uniprot id: U3CR85
uniprot id: U3CVV9
uniprot id: U3D197
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

9483:SYNM
gene id: 9483:SYNM
uniprot id: F7IPI2
uniprot id: U3BFC6
uniprot id: U3C005
names: Similarity
messages: Belongs to the intermediate filament family.

9483:SLC37A3
gene id: 9483:SLC37A3
uniprot id: F6S3H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9483:PDLIM3
gene id: 9483:PDLIM3
uniprot id: A0A8I3WPM0
uniprot id: F7IIG7
uniprot id: F7IKP8
names: Subcellular Location Annotation
messages: Z line

9483:GJA1
gene id: 9483:GJA1
uniprot id: F6S7E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:LOC100414342
gene id: 9483:LOC100414342
uniprot id: F7I4U5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:BABAM2
gene id: 9483:BABAM2
uniprot id: F6YLX2
uniprot id: F7BJZ6
uniprot id: U3FDV6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

9483:TEKT2
gene id: 9483:TEKT2
uniprot id: F7G6Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9483:PGM2
gene id: 9483:PGM2
uniprot id: F7IMS8
uniprot id: U3FIK5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9483:RRM2B
gene id: 9483:RRM2B
uniprot id: F7I7U4
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9483:DYNLL1
gene id: 9483:DYNLL1
uniprot id: F6UCC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9483:PEX2
gene id: 9483:PEX2
uniprot id: F6U7X0
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9483:EFEMP2
gene id: 9483:EFEMP2
uniprot id: U3CJ36
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:NPY1R
gene id: 9483:NPY1R
uniprot id: F7I5Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:BMP10
gene id: 9483:BMP10
uniprot id: F7IKG6
names: Similarity
messages: Belongs to the TGF-beta family.

9483:NRN1
gene id: 9483:NRN1
uniprot id: U3EMR7
names: Similarity
messages: Belongs to the neuritin family.

9483:BORCS5
gene id: 9483:BORCS5
uniprot id: F7IJ39
uniprot id: U3DRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9483:MGAT2
gene id: 9483:MGAT2
uniprot id: U3DIB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

9483:CD93
gene id: 9483:CD93
uniprot id: A0A8I3WL84
uniprot id: F7HWQ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SNX1
gene id: 9483:SNX1
uniprot id: F7I414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9483:EIF4EBP2
gene id: 9483:EIF4EBP2
uniprot id: F7I0B2
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9483:CHRD
gene id: 9483:CHRD
uniprot id: U3FTJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
messages: Secreted

9483:PAX4
gene id: 9483:PAX4
uniprot id: B0VXF5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:SMG9
gene id: 9483:SMG9
uniprot id: F6S2Q5
names: Similarity
messages: Belongs to the SMG9 family.

9483:STOML2
gene id: 9483:STOML2
uniprot id: F6XCA9
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9483:ATP6V1D
gene id: 9483:ATP6V1D
uniprot id: U3D2W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

9483:LOC100409982
gene id: 9483:LOC100409982
uniprot id: U3CM30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:LOC100405400
gene id: 9483:LOC100405400
uniprot id: A0A8I3W5B3
uniprot id: F7EQQ9
uniprot id: F7GZH4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

9483:IL4
gene id: 9483:IL4
uniprot id: A4ZXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
messages: Secreted

9483:SLC8A1
gene id: 9483:SLC8A1
uniprot id: F7A685
uniprot id: F7CV54
uniprot id: F7HA33
uniprot id: U3BXM2
uniprot id: U3DLI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9483:C4H6orf58
gene id: 9483:C4H6orf58
uniprot id: A0A8I3W6B0
uniprot id: F7EQS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9483:ELF3
gene id: 9483:ELF3
uniprot id: F7IHW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:SYF2
gene id: 9483:SYF2
uniprot id: U3FGF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

9483:CLDN18
gene id: 9483:CLDN18
uniprot id: A0A2R8M8V8
uniprot id: F6WTG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:CCNT1
gene id: 9483:CCNT1
uniprot id: F7I6V2
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

9483:WNT2B
gene id: 9483:WNT2B
uniprot id: A0A2R8MND7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:NPM1
gene id: 9483:NPM1
uniprot id: F7FL37
names: Similarity
messages: Belongs to the nucleoplasmin family.

9483:ERO1A
gene id: 9483:ERO1A
uniprot id: U3EXB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9483:GINS3
gene id: 9483:GINS3
uniprot id: F6T6J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9483:H2AFX
gene id: 9483:H2AFX
uniprot id: U3CDD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:CALU
gene id: 9483:CALU
uniprot id: A0A8I3WDK9
uniprot id: F7H0Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

9483:LOC100405438
gene id: 9483:LOC100405438
uniprot id: F6W224
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:SLC17A9
gene id: 9483:SLC17A9
uniprot id: A0A8I3WJT7
names: Subcellular Location Annotation
messages: Membrane

9483:EYA2
gene id: 9483:EYA2
uniprot id: F7HDB2
uniprot id: F7HWD0
uniprot id: F7HWE0
uniprot id: U3ECE7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9483:TSPAN5
gene id: 9483:TSPAN5
uniprot id: F6X7Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:SORD
gene id: 9483:SORD
uniprot id: U3FKU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 1 or 2 Zn(2+) ions per subunit.
messages: Homotetramer.
messages: Mitochondrion membrane
messages: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility.
messages: flagellum

9483:METTL3
gene id: 9483:METTL3
uniprot id: U3CYA0
names: Similarity
messages: Belongs to the MT-A70-like family.

9483:TSPYL1
gene id: 9483:TSPYL1
uniprot id: U3BLB6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:SLC2A6
gene id: 9483:SLC2A6
uniprot id: F7IAN0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9483:PGAM1
gene id: 9483:PGAM1
uniprot id: F6Y5Q5
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9483:PCSK9
gene id: 9483:PCSK9
uniprot id: A8T688
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Cell surface
messages: Cleavage by furin and PCSK5 generates a truncated inactive protein that is unable to induce LDLR degradation.
messages: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Endosome
messages: Golgi apparatus
messages: Its proteolytic activity is autoinhibited by the non-covalent binding of the propeptide to the catalytic domain. Inhibited by EGTA (By similarity).
messages: Lysosome
messages: Monomer. Can self-associate to form dimers and higher multimers which may have increased LDLR degrading activity. The precursor protein but not the mature protein may form multimers. Interacts with APOB, VLDLR, LRP8/APOER2 and BACE1. The full-length immature form (pro-PCSK9) interacts with SCNN1A, SCNN1B and SCNN1G. The pro-PCSK9 form (via C-terminal domain) interacts with LDLR. Interacts (via the C-terminal domain) with ANXA2 (via repeat Annexin 1); the interaction inhibits the degradation of LDLR.
messages: Phosphorylation protects the propeptide against proteolysis.
messages: Secreted
messages: The C-terminal domain (CRD) is essential for the LDLR-binding and degrading activities.
messages: The catalytic domain is responsible for mediating its self-association.
messages: Undergoes autocatalytic cleavage in the endoplasmic reticulum to release the propeptide from the N-terminus and the cleavage of the propeptide is strictly required for its maturation and activation. The cleaved propeptide however remains associated with the catalytic domain through non-covalent interactions, preventing potential substrates from accessing its active site. As a result, it is secreted from cells as a propeptide-containing, enzymatically inactive protein (By similarity).

9483:EXOC5
gene id: 9483:EXOC5
uniprot id: F7I3U0
names: Function
names: Similarity
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9483:CKM
gene id: 9483:CKM
uniprot id: U3BQ10
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9483:EML3
gene id: 9483:EML3
uniprot id: U3CJQ7
names: Subcellular Location Annotation
messages: cytoskeleton

9483:LOC100894898
gene id: 9483:LOC100894898
uniprot id: A0A2R8MPE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9483:CHGA
gene id: 9483:CHGA
uniprot id: F6SST6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9483:LOC100405375
gene id: 9483:LOC100405375
uniprot id: F7FGR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9483:SEC22B
gene id: 9483:SEC22B
uniprot id: F6UXM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9483:TM9SF2
gene id: 9483:TM9SF2
uniprot id: U3EFD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9483:EIF2D
gene id: 9483:EIF2D
uniprot id: F7IPX2
names: Similarity
messages: Belongs to the eIF2D family.

9483:RETREG3
gene id: 9483:RETREG3
uniprot id: F7HNU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9483:ARMC8
gene id: 9483:ARMC8
uniprot id: F6YNU3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:TXNL4B
gene id: 9483:TXNL4B
uniprot id: F7GNU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9483:LOC100407762
gene id: 9483:LOC100407762
uniprot id: A0A8I3W090
names: Similarity
messages: Belongs to the LCE family.

9483:SNAP91
gene id: 9483:SNAP91
uniprot id: U3EHA3
uniprot id: U3F4M1
uniprot id: U3FWV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

9483:GPD1L
gene id: 9483:GPD1L
uniprot id: A0A2R8NA53
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9483:FAM131C
gene id: 9483:FAM131C
uniprot id: U3FI24
names: Similarity
messages: Belongs to the FAM131 family.

9483:MGAT5
gene id: 9483:MGAT5
uniprot id: F6RNJ2
uniprot id: U3BBB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9483:DLX1
gene id: 9483:DLX1
uniprot id: A0A2R8N712
names: Subcellular Location Annotation
messages: Nucleus

9483:NME7
gene id: 9483:NME7
uniprot id: U3E823
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9483:IL6
gene id: 9483:IL6
uniprot id: Q0Z973
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9483:ABL1
gene id: 9483:ABL1
uniprot id: U3BH45
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:YKT6
gene id: 9483:YKT6
uniprot id: F7HXA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9483:CCNA2
gene id: 9483:CCNA2
uniprot id: F7ILU7
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9483:WNT7A
gene id: 9483:WNT7A
uniprot id: Q1KYK6
uniprot id: U3CFU1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Wnt family.
messages: Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with FZD5. Interacts with PORCN (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (By similarity).
messages: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity).
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.
messages: extracellular matrix

9483:TSNAX
gene id: 9483:TSNAX
uniprot id: F6TPC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9483:ITGA8
gene id: 9483:ITGA8
uniprot id: F7ALM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9483:TMEM63C
gene id: 9483:TMEM63C
uniprot id: U3DJC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9483:TMEM19
gene id: 9483:TMEM19
uniprot id: A0A8I4A1H3
uniprot id: F7I299
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

9483:PLA2G15
gene id: 9483:PLA2G15
uniprot id: U3DIC7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:SULT1A3
gene id: 9483:SULT1A3
uniprot id: F7I9X0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9483:ALOX5AP
gene id: 9483:ALOX5AP
uniprot id: F7ILH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:HARBI1
gene id: 9483:HARBI1
uniprot id: F6TKC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9483:NKIRAS1
gene id: 9483:NKIRAS1
uniprot id: F7H5N4
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9483:KRT13
gene id: 9483:KRT13
uniprot id: F7AP91
names: Similarity
messages: Belongs to the intermediate filament family.

9483:TNS3
gene id: 9483:TNS3
uniprot id: U3C992
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9483:C12H16orf91
gene id: 9483:C12H16orf91
uniprot id: F7IQR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSMST1 family.
messages: Membrane

9483:ABCG2
gene id: 9483:ABCG2
uniprot id: F7D5A9
uniprot id: U3EDG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

9483:CYP8B1
gene id: 9483:CYP8B1
uniprot id: A0A7G0Y586
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9483:H1-4
gene id: 9483:H1-4
uniprot id: U3D8R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9483:CSN3
gene id: 9483:CSN3
uniprot id: F7INL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Secreted

9483:HOXB6
gene id: 9483:HOXB6
uniprot id: F6ZVZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:NOP2
gene id: 9483:NOP2
uniprot id: U3CIU4
uniprot id: U3EPC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

9483:KCTD20
gene id: 9483:KCTD20
uniprot id: F7IJE3
names: Subcellular Location Annotation
messages: Cytoplasm

9483:UCMA
gene id: 9483:UCMA
uniprot id: F7HYB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

9483:METTL1
gene id: 9483:METTL1
uniprot id: U3D6D9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with WDR4.
messages: Nucleus
messages: Phosphorylation at Ser-27 inactivates its catalytic activity but does not affect the interaction with WDR4.

9483:SMU1
gene id: 9483:SMU1
uniprot id: F7HXH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

9483:HOXD10
gene id: 9483:HOXD10
uniprot id: F7G643
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9483:TUBB1
gene id: 9483:TUBB1
uniprot id: A0A8I3W422
uniprot id: F7I1T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9483:LOC100395473
gene id: 9483:LOC100395473
uniprot id: H9KWM8
names: Similarity
messages: Belongs to the GAGE family.

9483:PCSK1
gene id: 9483:PCSK1
uniprot id: U3F9M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9483:GATC
gene id: 9483:GATC
uniprot id: F7I2M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9483:GTF2E2
gene id: 9483:GTF2E2
uniprot id: U3B951
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9483:HOOK3
gene id: 9483:HOOK3
uniprot id: U3FCZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9483:PISD
gene id: 9483:PISD
uniprot id: B0KWR7
uniprot id: F7GK51
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9483:DXO
gene id: 9483:DXO
uniprot id: F6XJ66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

9483:STK17A
gene id: 9483:STK17A
uniprot id: U3B905
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:RPS10
gene id: 9483:RPS10
uniprot id: A0A2R8N9P5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9483:TMEM41A
gene id: 9483:TMEM41A
uniprot id: A0A2R8PDW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9483:CPNE8
gene id: 9483:CPNE8
uniprot id: F6RB22
names: Similarity
messages: Belongs to the copine family.

9483:BICD1
gene id: 9483:BICD1
uniprot id: A0A8I3WHB3
uniprot id: F6Q1B3
uniprot id: F6QBM4
uniprot id: U3DJ15
names: Similarity
messages: Belongs to the BicD family.

9483:CLDN10
gene id: 9483:CLDN10
uniprot id: F7FY51
uniprot id: U3DXA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:RHOT2
gene id: 9483:RHOT2
uniprot id: U3D3G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9483:KCNK16
gene id: 9483:KCNK16
uniprot id: F7HMK7
uniprot id: F7HTD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9483:FOLR1
gene id: 9483:FOLR1
uniprot id: A0A2R8MPG7
names: Similarity
messages: Belongs to the folate receptor family.

9483:EGR3
gene id: 9483:EGR3
uniprot id: F7G285
uniprot id: U3CAC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9483:PLAU
gene id: 9483:PLAU
uniprot id: U3D503
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9483:METTL14
gene id: 9483:METTL14
uniprot id: A0A2R8NAC2
names: Similarity
messages: Belongs to the MT-A70-like family.

9483:ATP6V1H
gene id: 9483:ATP6V1H
uniprot id: F7HPP7
uniprot id: F7HPQ6
uniprot id: U3BXQ6
uniprot id: U3CFY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9483:SYS1
gene id: 9483:SYS1
uniprot id: A0A2R8P1U4
uniprot id: U3ECS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9483:LOC100390305
gene id: 9483:LOC100390305
uniprot id: A0A2R8MA88
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9483:MRPL19
gene id: 9483:MRPL19
uniprot id: U3B9S5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

9483:GNAQ
gene id: 9483:GNAQ
uniprot id: F7IC22
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9483:KCNH3
gene id: 9483:KCNH3
uniprot id: F7IQF7
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9483:MVD
gene id: 9483:MVD
uniprot id: F7H2S1
uniprot id: U3B9E3
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

9483:HLCS
gene id: 9483:HLCS
uniprot id: U3BVA4
names: Similarity
messages: Belongs to the biotin--protein ligase family.

9483:SPARC
gene id: 9483:SPARC
uniprot id: A0A2R8MQN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9483:LOC100400790
gene id: 9483:LOC100400790
uniprot id: F7GV17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

9483:NOP14
gene id: 9483:NOP14
uniprot id: F7IE93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9483:OR2T11
gene id: 9483:OR2T11
uniprot id: F7HDZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ASB6
gene id: 9483:ASB6
uniprot id: U3FHX1
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:PITPNM1
gene id: 9483:PITPNM1
uniprot id: U3CSB1
uniprot id: U3FWY1
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9483:PSME2
gene id: 9483:PSME2
uniprot id: U3CVT8
names: Similarity
messages: Belongs to the PA28 family.

9483:HNRNPD
gene id: 9483:HNRNPD
uniprot id: U3C780
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:NTAQ1
gene id: 9483:NTAQ1
uniprot id: U3B6I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

9483:MCRIP1
gene id: 9483:MCRIP1
uniprot id: H9KVX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9483:HPSE2
gene id: 9483:HPSE2
uniprot id: U3BP05
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9483:COX1
gene id: 9483:COX1
uniprot id: A0A0U1XM35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9483:KIZ
gene id: 9483:KIZ
uniprot id: U3B928
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9483:SNRPN
gene id: 9483:SNRPN
uniprot id: F7EBE1
names: Similarity
messages: Belongs to the SNURF family.

9483:MMP3
gene id: 9483:MMP3
uniprot id: F7IPB7
names: Similarity
messages: Belongs to the peptidase M10A family.

9483:ASZ1
gene id: 9483:ASZ1
uniprot id: Q2QLG0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

9483:GCNT1
gene id: 9483:GCNT1
uniprot id: F7A7G8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9483:STX17
gene id: 9483:STX17
uniprot id: F7DHB4
uniprot id: U3BX97
names: Similarity
messages: Belongs to the syntaxin family.

9483:DES
gene id: 9483:DES
uniprot id: B0KWJ0
names: Similarity
messages: Belongs to the intermediate filament family.

9483:PSMC4
gene id: 9483:PSMC4
uniprot id: U3CPR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

9483:ADSS1
gene id: 9483:ADSS1
uniprot id: U3F1Z4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9483:RFNG
gene id: 9483:RFNG
uniprot id: F6SII8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:ALDH8A1
gene id: 9483:ALDH8A1
uniprot id: F7HZS8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:IMPA2
gene id: 9483:IMPA2
uniprot id: U3DAH9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9483:P2RX7
gene id: 9483:P2RX7
uniprot id: F7HRX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9483:HSPB8
gene id: 9483:HSPB8
uniprot id: F7ALK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

9483:EZH2
gene id: 9483:EZH2
uniprot id: A0A5K1USM6
uniprot id: F7EPM9
uniprot id: F7EPP0
uniprot id: F7F310
uniprot id: U3DM49
names: Subcellular Location Annotation
messages: Nucleus

9483:CALHM2
gene id: 9483:CALHM2
uniprot id: F6QN32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9483:CREB3L2
gene id: 9483:CREB3L2
uniprot id: F7I3W1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9483:RNH1
gene id: 9483:RNH1
uniprot id: F7HNE6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9483:DUSP1
gene id: 9483:DUSP1
uniprot id: U3FNS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9483:DMAP1
gene id: 9483:DMAP1
uniprot id: F6PIU9
names: Subcellular Location Annotation
messages: Nucleus

9483:ND6
gene id: 9483:ND6
uniprot id: E1CJC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9483:GABRG1
gene id: 9483:GABRG1
uniprot id: U3EFS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:POLR2A
gene id: 9483:POLR2A
uniprot id: F7IJW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9483:PMF1
gene id: 9483:PMF1
uniprot id: F7AAA0
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

9483:NOXRED1
gene id: 9483:NOXRED1
uniprot id: F6YLK1
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9483:SH2D1A
gene id: 9483:SH2D1A
uniprot id: A0A8I3X5W5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

9483:CYB5R1
gene id: 9483:CYB5R1
uniprot id: F7I687
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9483:BABAM1
gene id: 9483:BABAM1
uniprot id: U3C3M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9483:GLRX
gene id: 9483:GLRX
uniprot id: F7HFZ7
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9483:PGLYRP2
gene id: 9483:PGLYRP2
uniprot id: F6XHP9
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9483:ITGB5
gene id: 9483:ITGB5
uniprot id: U3FGD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9483:AKIRIN1
gene id: 9483:AKIRIN1
uniprot id: F7B8Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9483:CTSV
gene id: 9483:CTSV
uniprot id: A0A2R8M4M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9483:G6PD
gene id: 9483:G6PD
uniprot id: F7A518
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

9483:RHBDL2
gene id: 9483:RHBDL2
uniprot id: F7C7A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9483:LOC100392617
gene id: 9483:LOC100392617
uniprot id: U3DF39
names: Similarity
messages: Belongs to the cytochrome b5 family.

9483:CHMP4C
gene id: 9483:CHMP4C
uniprot id: F6SNN9
uniprot id: U3FI70
names: Similarity
messages: Belongs to the SNF7 family.

9483:AKAP5
gene id: 9483:AKAP5
uniprot id: F7GXY9
names: Subcellular Location Annotation
messages: Membrane

9483:ITPKB
gene id: 9483:ITPKB
uniprot id: U3FPY5
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9483:ORMDL3
gene id: 9483:ORMDL3
uniprot id: F7H4F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

9483:ATP5PF
gene id: 9483:ATP5PF
uniprot id: A0A2R8PKJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9483:AP1S3
gene id: 9483:AP1S3
uniprot id: A0A2R8M4W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9483:DOC2A
gene id: 9483:DOC2A
uniprot id: F6TWS2
names: Subcellular Location Annotation
messages: Membrane

9483:ZSCAN1
gene id: 9483:ZSCAN1
uniprot id: U3EI90
names: Subcellular Location Annotation
messages: Nucleus

9483:CIAPIN1
gene id: 9483:CIAPIN1
uniprot id: U3FXU7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9483:IL17D
gene id: 9483:IL17D
uniprot id: F7I5Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9483:CLTC
gene id: 9483:CLTC
uniprot id: F7IN80
uniprot id: U3D6K0
uniprot id: U3F8X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9483:SFXN4
gene id: 9483:SFXN4
uniprot id: F7H4D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9483:MRPL30
gene id: 9483:MRPL30
uniprot id: A0A8J8XZK6
uniprot id: U3D6P9
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9483:CDH22
gene id: 9483:CDH22
uniprot id: F7ICI7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:YIPF1
gene id: 9483:YIPF1
uniprot id: F7IHH0
uniprot id: F7IHH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9483:OTOGL
gene id: 9483:OTOGL
uniprot id: F7GS29
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:HBS1L
gene id: 9483:HBS1L
uniprot id: F7HXM1
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Interacts with the SKI complex.

9483:ATL2
gene id: 9483:ATL2
uniprot id: U3F853
uniprot id: U3FVA3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9483:APEX1
gene id: 9483:APEX1
uniprot id: F7HKI5
uniprot id: U3F4F7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9483:TRUB2
gene id: 9483:TRUB2
uniprot id: U3ENQ0
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9483:BOK
gene id: 9483:BOK
uniprot id: F6SBR3
uniprot id: U3CXP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9483:MRPL13
gene id: 9483:MRPL13
uniprot id: F7GRV5
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9483:YWHAB
gene id: 9483:YWHAB
uniprot id: U3F717
names: Similarity
messages: Belongs to the 14-3-3 family.

9483:OCIAD1
gene id: 9483:OCIAD1
uniprot id: F7IPT3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

9483:MTHFD2L
gene id: 9483:MTHFD2L
uniprot id: F6ZFR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities.
messages: Mitochondrion inner membrane

9483:LOC100410248
gene id: 9483:LOC100410248
uniprot id: B0VXB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CYP2C18
gene id: 9483:CYP2C18
uniprot id: A0A171P0Y7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:NDUFAF2
gene id: 9483:NDUFAF2
uniprot id: A0A8I3W4X9
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9483:PADI3
gene id: 9483:PADI3
uniprot id: A0A5K1VSB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9483:DPP7
gene id: 9483:DPP7
uniprot id: F7EFW5
names: Similarity
messages: Belongs to the peptidase S28 family.

9483:TH
gene id: 9483:TH
uniprot id: U3EG89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region
messages: synaptic vesicle

9483:LRRFIP2
gene id: 9483:LRRFIP2
uniprot id: U3B8X9
uniprot id: U3CUM9
names: Similarity
messages: Belongs to the LRRFIP family.

9483:CPLX3
gene id: 9483:CPLX3
uniprot id: F6WRU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9483:EDIL3
gene id: 9483:EDIL3
uniprot id: U3FSU1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LIPK
gene id: 9483:LIPK
uniprot id: F7HHI7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:ALG6
gene id: 9483:ALG6
uniprot id: U3BC09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:ARF1
gene id: 9483:ARF1
uniprot id: F6W8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9483:PTPA
gene id: 9483:PTPA
uniprot id: B0KWF1
uniprot id: F6VY34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:FLVCR1
gene id: 9483:FLVCR1
uniprot id: F6W512
names: Subcellular Location Annotation
messages: Membrane

9483:ANKRD13B
gene id: 9483:ANKRD13B
uniprot id: F6XYJ2
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9483:ZNF202
gene id: 9483:ZNF202
uniprot id: F7I290
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100401281
gene id: 9483:LOC100401281
uniprot id: F7A3K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9483:REXO2
gene id: 9483:REXO2
uniprot id: U3DGZ4
names: Similarity
messages: Belongs to the oligoribonuclease family.

9483:RPLP0
gene id: 9483:RPLP0
uniprot id: F6WAG2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9483:HPS6
gene id: 9483:HPS6
uniprot id: F7G6I5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

9483:FGF5
gene id: 9483:FGF5
uniprot id: F7DBG3
uniprot id: F7G2W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

9483:SEC11C
gene id: 9483:SEC11C
uniprot id: U3BJG9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:TAS2R7
gene id: 9483:TAS2R7
uniprot id: F7I087
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
messages: Membrane

9483:LOC100389983
gene id: 9483:LOC100389983
uniprot id: F7INI1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:WFIKKN2
gene id: 9483:WFIKKN2
uniprot id: A0A5F4VT19
uniprot id: F7ISD7
names: Similarity
messages: Belongs to the WFIKKN family.

9483:MARK4
gene id: 9483:MARK4
uniprot id: U3BWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9483:SOX2
gene id: 9483:SOX2
uniprot id: F7H274
names: Subcellular Location Annotation
messages: Nucleus

9483:INPP4B
gene id: 9483:INPP4B
uniprot id: F7IRC6
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9483:ATOH7
gene id: 9483:ATOH7
uniprot id: A0A2R8NEN1
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

9483:HAMP
gene id: 9483:HAMP
uniprot id: F6TFL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9483:RBM8A
gene id: 9483:RBM8A
uniprot id: F7DRZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9483:PRR5L
gene id: 9483:PRR5L
uniprot id: F7F5F5
names: Similarity
messages: Belongs to the PROTOR family.

9483:ATP6V0A2
gene id: 9483:ATP6V0A2
uniprot id: F7IBX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9483:RIOK1
gene id: 9483:RIOK1
uniprot id: F7G1T7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9483:COQ10A
gene id: 9483:COQ10A
uniprot id: F7EC97
uniprot id: F7EQA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9483:MGA
gene id: 9483:MGA
uniprot id: F7INH6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:ANKZF1
gene id: 9483:ANKZF1
uniprot id: A0A5F4WEP3
uniprot id: F6QSL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

9483:ATP6V1E2
gene id: 9483:ATP6V1E2
uniprot id: A0A2R8MGJ7
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9483:C13H18orf32
gene id: 9483:C13H18orf32
uniprot id: F7I248
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

9483:IL13RA2
gene id: 9483:IL13RA2
uniprot id: F6T9T2
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.

9483:CHST12
gene id: 9483:CHST12
uniprot id: F7INE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:CDC42EP5
gene id: 9483:CDC42EP5
uniprot id: B0VXJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9483:UFL1
gene id: 9483:UFL1
uniprot id: F7ILA7
names: Similarity
messages: Belongs to the UFL1 family.

9483:ACTL9
gene id: 9483:ACTL9
uniprot id: F7FGP2
names: Similarity
messages: Belongs to the actin family.

9483:DLG1
gene id: 9483:DLG1
uniprot id: F6UVX1
uniprot id: F7CD69
uniprot id: F7IK82
uniprot id: U3E5S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9483:LOC100385103
gene id: 9483:LOC100385103
uniprot id: F6R8W5
uniprot id: F6T494
uniprot id: F7GYJ8
uniprot id: U3B2I5
names: Similarity
messages: Belongs to the GroES chaperonin family.
messages: Belongs to the MOB1/phocein family.

9483:GPR182
gene id: 9483:GPR182
uniprot id: F6QCH0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:SLC12A5
gene id: 9483:SLC12A5
uniprot id: A0A2R8MQZ5
uniprot id: A0A8J8XPH1
uniprot id: U3CZY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9483:LOC100392421
gene id: 9483:LOC100392421
uniprot id: F7HWD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9483:WWOX
gene id: 9483:WWOX
uniprot id: U3FE30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

9483:MMD
gene id: 9483:MMD
uniprot id: A0A2R8MEW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9483:HTR1D
gene id: 9483:HTR1D
uniprot id: F6V9Y1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9483:HACD3
gene id: 9483:HACD3
uniprot id: A0A8I3W6C9
uniprot id: F7HIV9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CYFIP1
gene id: 9483:CYFIP1
uniprot id: F7HHC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9483:RND3
gene id: 9483:RND3
uniprot id: F7HJC5
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

9483:OPRPN
gene id: 9483:OPRPN
uniprot id: F7IIU0
names: Subcellular Location Annotation
messages: Secreted

9483:GADD45GIP1
gene id: 9483:GADD45GIP1
uniprot id: U3DS82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

9483:OR6X1
gene id: 9483:OR6X1
uniprot id: F7GP36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TMTC4
gene id: 9483:TMTC4
uniprot id: A0A8I3VYA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9483:SMARCD2
gene id: 9483:SMARCD2
uniprot id: U3EEK9
names: Similarity
messages: Belongs to the SMARCD family.

9483:KIN
gene id: 9483:KIN
uniprot id: F7CBX1
uniprot id: F7I709
uniprot id: U3CW28
names: Similarity
messages: Belongs to the KIN17 family.

9483:GOLPH3L
gene id: 9483:GOLPH3L
uniprot id: F7H8H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9483:EID2
gene id: 9483:EID2
uniprot id: U3CRD8
names: Subcellular Location Annotation
messages: Nucleus

9483:CAMLG
gene id: 9483:CAMLG
uniprot id: F7HWS9
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9483:LAMP2
gene id: 9483:LAMP2
uniprot id: F7AKL6
uniprot id: F7AKN2
uniprot id: U3DL73
uniprot id: U3F301
uniprot id: U3FB69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9483:TAAR1
gene id: 9483:TAAR1
uniprot id: D2X5Q2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:TMEM147
gene id: 9483:TMEM147
uniprot id: F7GQ14
uniprot id: U3BC08
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:MLF2
gene id: 9483:MLF2
uniprot id: F7HZZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9483:SAT1
gene id: 9483:SAT1
uniprot id: F7HNS3
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Homodimer.

9483:NSUN6
gene id: 9483:NSUN6
uniprot id: F7EM71
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9483:CUL3
gene id: 9483:CUL3
uniprot id: F7GYK0
uniprot id: F7IHN1
names: Similarity
messages: Belongs to the cullin family.

9483:TOR2A
gene id: 9483:TOR2A
uniprot id: A0A2R8MYK2
uniprot id: U3BYS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9483:PRKRIP1
gene id: 9483:PRKRIP1
uniprot id: F7I545
names: Similarity
messages: Belongs to the PRKRIP1 family.

9483:TXNIP
gene id: 9483:TXNIP
uniprot id: F7GFR5
names: Similarity
messages: Belongs to the arrestin family.

9483:XPA
gene id: 9483:XPA
uniprot id: U3DQN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9483:PGA
gene id: 9483:PGA
uniprot id: Q9N2D4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Inhibited by pepstatin.
messages: Secreted
messages: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

9483:TNFSF4
gene id: 9483:TNFSF4
uniprot id: F7IAD3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:AK5
gene id: 9483:AK5
uniprot id: F6RG37
uniprot id: U3F4C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

9483:ENKUR
gene id: 9483:ENKUR
uniprot id: F7IJ15
names: Subcellular Location Annotation
messages: cilium axoneme

9483:SHBG
gene id: 9483:SHBG
uniprot id: F7E805
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SUPT3H
gene id: 9483:SUPT3H
uniprot id: U3D6N9
names: Subcellular Location Annotation
messages: Nucleus

9483:SARAF
gene id: 9483:SARAF
uniprot id: U3E7B2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9483:EIF5A2
gene id: 9483:EIF5A2
uniprot id: F6YNW2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

9483:SLC10A4
gene id: 9483:SLC10A4
uniprot id: F7I5S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9483:AMD1
gene id: 9483:AMD1
uniprot id: F7FZ33
uniprot id: U3DMU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9483:XPO7
gene id: 9483:XPO7
uniprot id: A0A5K1VUN1
uniprot id: F6UP51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

9483:MAB21L2
gene id: 9483:MAB21L2
uniprot id: A0A5F4VWY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

9483:AVIL
gene id: 9483:AVIL
uniprot id: F7DRQ4
names: Similarity
messages: Belongs to the villin/gelsolin family.

9483:CD59
gene id: 9483:CD59
uniprot id: F6SUS4
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with T-cell surface antigen CD2.
messages: Membrane

9483:LOC103792017
gene id: 9483:LOC103792017
uniprot id: A0A6G6XDN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9483:IRX3
gene id: 9483:IRX3
uniprot id: F7INF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9483:AKAP9
gene id: 9483:AKAP9
uniprot id: U3FQ11
names: Subcellular Location Annotation
messages: centrosome

9483:LDLRAD3
gene id: 9483:LDLRAD3
uniprot id: U3C0H8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:KDM4A
gene id: 9483:KDM4A
uniprot id: U3CZ58
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

9483:DDAH2
gene id: 9483:DDAH2
uniprot id: U3E282
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9483:AOX1
gene id: 9483:AOX1
uniprot id: M1ZMR7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9483:CDCA5
gene id: 9483:CDCA5
uniprot id: F7BP81
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9483:LOC100407633
gene id: 9483:LOC100407633
uniprot id: F7IFS4
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9483:FXYD5
gene id: 9483:FXYD5
uniprot id: F6RV87
names: Similarity
messages: Belongs to the FXYD family.

9483:NETO2
gene id: 9483:NETO2
uniprot id: F7I2J9
uniprot id: U3F8R6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CLIC1
gene id: 9483:CLIC1
uniprot id: F7IM19
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9483:PRKD3
gene id: 9483:PRKD3
uniprot id: F6PTR4
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9483:PRIM2
gene id: 9483:PRIM2
uniprot id: U3BC63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

9483:ALOX12
gene id: 9483:ALOX12
uniprot id: U3B0U1
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC100403660
gene id: 9483:LOC100403660
uniprot id: A0A5F4VWF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100395052
gene id: 9483:LOC100395052
uniprot id: F6W0P4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9483:CX3CR1
gene id: 9483:CX3CR1
uniprot id: F7I7I1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9483:FOXP2
gene id: 9483:FOXP2
uniprot id: F7IF16
names: Subcellular Location Annotation
messages: Nucleus

9483:MELK
gene id: 9483:MELK
uniprot id: F6SKD5
uniprot id: F7HM37
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9483:AKR1C1
gene id: 9483:AKR1C1
uniprot id: F7HVF7
uniprot id: U3FQT3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9483:PPP4R3B
gene id: 9483:PPP4R3B
uniprot id: U3DMP4
names: Similarity
messages: Belongs to the SMEK family.

9483:ACAT1
gene id: 9483:ACAT1
uniprot id: U3CCI8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9483:HOXC12
gene id: 9483:HOXC12
uniprot id: F7IAK9
names: Subcellular Location Annotation
messages: Nucleus

9483:UBA3
gene id: 9483:UBA3
uniprot id: F6QVE0
uniprot id: F6R524
uniprot id: U3DEY7
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

9483:SDHAF3
gene id: 9483:SDHAF3
uniprot id: A0A2R8M3V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9483:TRAK2
gene id: 9483:TRAK2
uniprot id: F7DNV2
uniprot id: U3FJ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9483:CRCP
gene id: 9483:CRCP
uniprot id: F6TNU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9483:TMED9
gene id: 9483:TMED9
uniprot id: A0A2R8M2U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:FAM122C
gene id: 9483:FAM122C
uniprot id: A0A5F4VWX2
names: Similarity
messages: Belongs to the FAM122 family.

9483:RP2
gene id: 9483:RP2
uniprot id: F6ZU00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

9483:GTF2A2
gene id: 9483:GTF2A2
uniprot id: U3FTN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9483:CLEC12B
gene id: 9483:CLEC12B
uniprot id: F7IR53
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:SEMA3A
gene id: 9483:SEMA3A
uniprot id: F7DYT5
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:HHIPL1
gene id: 9483:HHIPL1
uniprot id: A0A8J8YNE3
uniprot id: F7GMI4
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SLAIN2
gene id: 9483:SLAIN2
uniprot id: A0A2R8M343
uniprot id: U3BI85
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9483:LOC100385521
gene id: 9483:LOC100385521
uniprot id: A0A5F4WK63
names: Similarity
messages: Belongs to the gonadal family.

9483:FGB
gene id: 9483:FGB
uniprot id: F7FU68
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9483:ATP11A
gene id: 9483:ATP11A
uniprot id: A0A2R8N6S8
uniprot id: A0A8I3VWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9483:CD63
gene id: 9483:CD63
uniprot id: F7IIJ9
uniprot id: U3CZ61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

9483:TRIT1
gene id: 9483:TRIT1
uniprot id: U3FSI0
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9483:HS2ST1
gene id: 9483:HS2ST1
uniprot id: F6XRF3
uniprot id: U3BYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

9483:IST1
gene id: 9483:IST1
uniprot id: A0A2R8M5C4
uniprot id: F7HET2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9483:FZD3
gene id: 9483:FZD3
uniprot id: U3CNR2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:KLHL40
gene id: 9483:KLHL40
uniprot id: F6QF90
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

9483:OLFML3
gene id: 9483:OLFML3
uniprot id: F7I8J0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:NME3
gene id: 9483:NME3
uniprot id: F7FUB6
names: Similarity
messages: Belongs to the NDK family.

9483:PPP1R21
gene id: 9483:PPP1R21
uniprot id: F7FNC9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9483:HOXC11
gene id: 9483:HOXC11
uniprot id: F7IAK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9483:TFB2M
gene id: 9483:TFB2M
uniprot id: A0A8I4A234
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

9483:FAM187A
gene id: 9483:FAM187A
uniprot id: A0A5F4WC65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

9483:MYADML2
gene id: 9483:MYADML2
uniprot id: A0A2R8MAB6
names: Subcellular Location Annotation
messages: Membrane

9483:LOC103790833
gene id: 9483:LOC103790833
uniprot id: F7C9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9483:SEPHS1
gene id: 9483:SEPHS1
uniprot id: F7I2Y6
uniprot id: U3AXP7
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9483:KCNN3
gene id: 9483:KCNN3
uniprot id: F7I0V2
names: Subcellular Location Annotation
messages: Membrane

9483:PHYKPL
gene id: 9483:PHYKPL
uniprot id: F7IK22
uniprot id: U3BHS3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9483:ST6GALNAC2
gene id: 9483:ST6GALNAC2
uniprot id: F7H4E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:PTGDR
gene id: 9483:PTGDR
uniprot id: A0A2R8NFM2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:GSTA4
gene id: 9483:GSTA4
uniprot id: F7GQS8
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9483:GLS2
gene id: 9483:GLS2
uniprot id: F7ETF8
names: Similarity
messages: Belongs to the glutaminase family.

9483:LOC100388377
gene id: 9483:LOC100388377
uniprot id: U3DTS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9483:LRRC8B
gene id: 9483:LRRC8B
uniprot id: F7GPA1
uniprot id: U3ENT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9483:IPO11
gene id: 9483:IPO11
uniprot id: A0A8I3W4U3
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ARTN
gene id: 9483:ARTN
uniprot id: F6PVA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9483:CLDN20
gene id: 9483:CLDN20
uniprot id: A0A5F4W442
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:PCNA
gene id: 9483:PCNA
uniprot id: U3CWY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9483:CCDC130
gene id: 9483:CCDC130
uniprot id: F6Z9F1
names: Similarity
messages: Belongs to the CWC16 family.

9483:C2H5orf24
gene id: 9483:C2H5orf24
uniprot id: F7DCU5
uniprot id: F7HZ39
names: Similarity
messages: Belongs to the UPF0461 family.

9483:DEFB123
gene id: 9483:DEFB123
uniprot id: A0A8I3W278
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:TRAPPC9
gene id: 9483:TRAPPC9
uniprot id: A0A8I4A1E6
uniprot id: F6PQ29
names: Similarity
messages: Belongs to the NIBP family.

9483:PROZ
gene id: 9483:PROZ
uniprot id: F7H321
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LRRC8A
gene id: 9483:LRRC8A
uniprot id: B0KWE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9483:CELF1
gene id: 9483:CELF1
uniprot id: F6SMS6
uniprot id: F6YYB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9483:DNAJA2
gene id: 9483:DNAJA2
uniprot id: F7HVJ2
names: Subcellular Location Annotation
messages: Membrane

9483:TADA2A
gene id: 9483:TADA2A
uniprot id: U3BG35
names: Subcellular Location Annotation
messages: Nucleus

9483:HSPA4L
gene id: 9483:HSPA4L
uniprot id: U3B6H3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9483:FBXO46
gene id: 9483:FBXO46
uniprot id: U3FLG3
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9483:CREB5
gene id: 9483:CREB5
uniprot id: F7GZV5
uniprot id: F7HFJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

9483:CPE
gene id: 9483:CPE
uniprot id: U3CZP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Interacts with Secretogranin III/SCG3.
messages: Membrane
messages: Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
messages: Vesicle
messages: secretory vesicle membrane

9483:HINT2
gene id: 9483:HINT2
uniprot id: F7EQY7
names: Similarity
messages: Belongs to the HINT family.

9483:EFNA1
gene id: 9483:EFNA1
uniprot id: F7AMD6
uniprot id: F7B5R2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:DCAF11
gene id: 9483:DCAF11
uniprot id: U3BML7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9483:NANOS2
gene id: 9483:NANOS2
uniprot id: A0A2R8M6M2
names: Similarity
messages: Belongs to the nanos family.

9483:SMARCA4
gene id: 9483:SMARCA4
uniprot id: U3CUM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9483:PLA2G2F
gene id: 9483:PLA2G2F
uniprot id: F7DRN8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9483:PSPC1
gene id: 9483:PSPC1
uniprot id: F7I3U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: nucleolus

9483:FAM3C
gene id: 9483:FAM3C
uniprot id: F7IA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9483:MEF2C
gene id: 9483:MEF2C
uniprot id: A0A2R8MTX5
uniprot id: A0A2R8P582
uniprot id: F6YQS7
uniprot id: F7E2K3
uniprot id: U3EHQ5
names: Subcellular Location Annotation
messages: Nucleus

9483:PSMC1
gene id: 9483:PSMC1
uniprot id: F7DZ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9483:BTG3
gene id: 9483:BTG3
uniprot id: F7H6J9
names: Similarity
messages: Belongs to the BTG family.

9483:PDCL3
gene id: 9483:PDCL3
uniprot id: F7G7I6
names: Similarity
messages: Belongs to the phosducin family.

9483:OR1L3
gene id: 9483:OR1L3
uniprot id: F7B0Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TNFRSF11B
gene id: 9483:TNFRSF11B
uniprot id: F7HTR5
names: Caution
names: Function
names: Subunit
messages: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:NPTX1
gene id: 9483:NPTX1
uniprot id: U3FBQ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:NCAPD3
gene id: 9483:NCAPD3
uniprot id: U3CL76
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

9483:NIPSNAP1
gene id: 9483:NIPSNAP1
uniprot id: F7IGZ2
names: Similarity
messages: Belongs to the NipSnap family.

9483:FBXO45
gene id: 9483:FBXO45
uniprot id: F7GQ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FBXO45/Fsn family.
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:FOXC2
gene id: 9483:FOXC2
uniprot id: A0A2R8MRM9
names: Subcellular Location Annotation
messages: Nucleus

9483:HIGD2A
gene id: 9483:HIGD2A
uniprot id: F7IAW2
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9483:TRAM1L1
gene id: 9483:TRAM1L1
uniprot id: F7HFS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9483:GATM
gene id: 9483:GATM
uniprot id: F7GZ52
uniprot id: U3CX04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

9483:PKNOX1
gene id: 9483:PKNOX1
uniprot id: U3DEB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9483:COQ10B
gene id: 9483:COQ10B
uniprot id: A0A2R8MIC0
uniprot id: F6PJ77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9483:GPAM
gene id: 9483:GPAM
uniprot id: A0A8I3W879
uniprot id: F7HUP3
uniprot id: U3EST7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9483:PTAFR
gene id: 9483:PTAFR
uniprot id: F7IRI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

9483:PPP1R11
gene id: 9483:PPP1R11
uniprot id: F7IDX6
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9483:WFDC5
gene id: 9483:WFDC5
uniprot id: A4K2U0
names: Function
names: Subcellular Location Annotation
messages: Putative acid-stable proteinase inhibitor.
messages: Secreted

9483:ACSL5
gene id: 9483:ACSL5
uniprot id: A0A8I4A221
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9483:PEX12
gene id: 9483:PEX12
uniprot id: F7DEK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

9483:HIGD1A
gene id: 9483:HIGD1A
uniprot id: A0A8I3WK81
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9483:HBE1
gene id: 9483:HBE1
uniprot id: B0VXB7
uniprot id: P68026
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.
messages: Red blood cells.
messages: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

9483:TIMM17B
gene id: 9483:TIMM17B
uniprot id: F6Y398
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

9483:SRD5A3
gene id: 9483:SRD5A3
uniprot id: F6SQM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9483:ISCA2
gene id: 9483:ISCA2
uniprot id: F7HKC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9483:LHFPL4
gene id: 9483:LHFPL4
uniprot id: F7IP59
names: Subcellular Location Annotation
messages: Membrane

9483:STAC
gene id: 9483:STAC
uniprot id: F7HN23
names: Subcellular Location Annotation
messages: sarcolemma

9483:MRPL16
gene id: 9483:MRPL16
uniprot id: F6SEU8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9483:GADD45B
gene id: 9483:GADD45B
uniprot id: U3FG35
names: Similarity
messages: Belongs to the GADD45 family.

9483:UVSSA
gene id: 9483:UVSSA
uniprot id: U3AWY8
names: Similarity
messages: Belongs to the UVSSA family.

9483:TATDN1
gene id: 9483:TATDN1
uniprot id: U3CPY9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9483:BDH1
gene id: 9483:BDH1
uniprot id: U3C2M8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:FAM214A
gene id: 9483:FAM214A
uniprot id: U3DKZ8
names: Similarity
messages: Belongs to the FAM214 family.

9483:XPNPEP1
gene id: 9483:XPNPEP1
uniprot id: U3DFF7
names: Similarity
messages: Belongs to the peptidase M24B family.

9483:OAT
gene id: 9483:OAT
uniprot id: U3FT89
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9483:EEF2K
gene id: 9483:EEF2K
uniprot id: F7A4C9
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9483:IGFBP5
gene id: 9483:IGFBP5
uniprot id: F7HYX2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:TRPC1
gene id: 9483:TRPC1
uniprot id: U3D194
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9483:ORMDL1
gene id: 9483:ORMDL1
uniprot id: F7FQP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9483:CMC4
gene id: 9483:CMC4
uniprot id: F6WXF4
names: Similarity
messages: Belongs to the CMC4 family.

9483:GOT2
gene id: 9483:GOT2
uniprot id: F7GQT4
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9483:NXPH3
gene id: 9483:NXPH3
uniprot id: F7CES0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9483:SBF2
gene id: 9483:SBF2
uniprot id: A0A8I4A096
uniprot id: U3EI45
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9483:NME1
gene id: 9483:NME1
uniprot id: F6VUS6
names: Similarity
messages: Belongs to the NDK family.

9483:DNPH1
gene id: 9483:DNPH1
uniprot id: F7GWW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

9483:LRRC43
gene id: 9483:LRRC43
uniprot id: F6ZD37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:ARL6IP1
gene id: 9483:ARL6IP1
uniprot id: F7HAU7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

9483:SEC24A
gene id: 9483:SEC24A
uniprot id: U3D0H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9483:GFOD2
gene id: 9483:GFOD2
uniprot id: U3F7H2
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9483:YWHAE
gene id: 9483:YWHAE
uniprot id: A0A8I3W8K2
uniprot id: F7GZ27
names: Similarity
messages: Belongs to the 14-3-3 family.

9483:GPR108
gene id: 9483:GPR108
uniprot id: U3EP34
names: Subcellular Location Annotation
messages: Membrane

9483:SLC25A46
gene id: 9483:SLC25A46
uniprot id: F7I9N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:PDGFA
gene id: 9483:PDGFA
uniprot id: U3AUU7
uniprot id: U3CXU3
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9483:BUD23
gene id: 9483:BUD23
uniprot id: U3FA13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

9483:APMAP
gene id: 9483:APMAP
uniprot id: F6S5S8
names: Similarity
messages: Belongs to the strictosidine synthase family.

9483:SNRPA1
gene id: 9483:SNRPA1
uniprot id: F7IJG0
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

9483:ABCC5
gene id: 9483:ABCC5
uniprot id: U3CGH0
names: Function
names: Subunit
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.

9483:DOK4
gene id: 9483:DOK4
uniprot id: A0A5F4WCM8
uniprot id: U3DIP2
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9483:INHA
gene id: 9483:INHA
uniprot id: B0KWJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

9483:SFXN2
gene id: 9483:SFXN2
uniprot id: U3CYB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9483:PLCB3
gene id: 9483:PLCB3
uniprot id: U3BBD1
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9483:L3MBTL3
gene id: 9483:L3MBTL3
uniprot id: F7I9N0
uniprot id: U3D1Y4
names: Subcellular Location Annotation
messages: Nucleus

9483:DEFB118
gene id: 9483:DEFB118
uniprot id: A0A2R8MX32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:TRMT11
gene id: 9483:TRMT11
uniprot id: U3FI61
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

9483:TNFSF15
gene id: 9483:TNFSF15
uniprot id: A0A0U5J7D7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:ICMT
gene id: 9483:ICMT
uniprot id: F7GN70
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:EIF2S1
gene id: 9483:EIF2S1
uniprot id: F7ANJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

9483:RPL28
gene id: 9483:RPL28
uniprot id: F6VGW5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

9483:PPP4C
gene id: 9483:PPP4C
uniprot id: F6S3M7
names: Similarity
messages: Belongs to the PPP phosphatase family.

9483:CCKBR
gene id: 9483:CCKBR
uniprot id: A0A2R8NCK1
uniprot id: F7INJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9483:CAND1
gene id: 9483:CAND1
uniprot id: F6XT20
names: Similarity
messages: Belongs to the CAND family.

9483:CPLX4
gene id: 9483:CPLX4
uniprot id: A0A5F4VUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9483:IL1RAPL1
gene id: 9483:IL1RAPL1
uniprot id: F7IJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9483:FUT8
gene id: 9483:FUT8
uniprot id: A0A8I4A409
uniprot id: F7CXF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9483:PHOX2B
gene id: 9483:PHOX2B
uniprot id: A0A2R8PD18
names: Subcellular Location Annotation
messages: Nucleus

9483:ND2
gene id: 9483:ND2
uniprot id: E1CJB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9483:PPM1F
gene id: 9483:PPM1F
uniprot id: F7AD27
names: Similarity
messages: Belongs to the PP2C family.

9483:SLC16A9
gene id: 9483:SLC16A9
uniprot id: F6SCZ2
names: Subcellular Location Annotation
messages: Membrane

9483:PARL
gene id: 9483:PARL
uniprot id: U3BKB5
uniprot id: U3C4X5
names: Subcellular Location Annotation
messages: Membrane

9483:SMPX
gene id: 9483:SMPX
uniprot id: F7DME5
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

9483:GSS
gene id: 9483:GSS
uniprot id: Q1HGK4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9483:CBX3
gene id: 9483:CBX3
uniprot id: F7IQM9
uniprot id: U3E4T3
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100396934
gene id: 9483:LOC100396934
uniprot id: F7IIN0
uniprot id: F7IKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Nucleus

9483:FAM174B
gene id: 9483:FAM174B
uniprot id: A0A5F4WFP2
uniprot id: A0A8I3W409
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9483:INSR
gene id: 9483:INSR
uniprot id: U3FCC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9483:S100A2
gene id: 9483:S100A2
uniprot id: F6ZM10
names: Similarity
messages: Belongs to the S-100 family.

9483:TLE3
gene id: 9483:TLE3
uniprot id: F7AJC5
uniprot id: F7B2J0
uniprot id: U3CYK1
uniprot id: U3FTL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9483:LOC100411089
gene id: 9483:LOC100411089
uniprot id: A0A5F4W7M7
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

9483:GHRL
gene id: 9483:GHRL
uniprot id: F7BAW5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted

9483:TMTC3
gene id: 9483:TMTC3
uniprot id: U3EIN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9483:RPS19
gene id: 9483:RPS19
uniprot id: F7DXF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

9483:GLI1
gene id: 9483:GLI1
uniprot id: F7AEX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9483:ADTRP
gene id: 9483:ADTRP
uniprot id: F7DN37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9483:ARSK
gene id: 9483:ARSK
uniprot id: F7GPX9
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9483:DNAJB12
gene id: 9483:DNAJB12
uniprot id: F7CSU9
uniprot id: U3DLP5
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100385852
gene id: 9483:LOC100385852
uniprot id: B0VXD3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:CDK5RAP1
gene id: 9483:CDK5RAP1
uniprot id: U3CBQ1
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

9483:ITPRIPL2
gene id: 9483:ITPRIPL2
uniprot id: U3CUS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9483:MEMO1
gene id: 9483:MEMO1
uniprot id: U3BKM6
names: Similarity
messages: Belongs to the MEMO1 family.

9483:VAMP4
gene id: 9483:VAMP4
uniprot id: F6W2F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9483:HYAL2
gene id: 9483:HYAL2
uniprot id: F7HIH6
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9483:MDFIC
gene id: 9483:MDFIC
uniprot id: F7ICM6
names: Similarity
messages: Belongs to the MDFI family.

9483:ITK
gene id: 9483:ITK
uniprot id: F7IG16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9483:ATP2C2
gene id: 9483:ATP2C2
uniprot id: A0A5F4VXF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SELENBP1
gene id: 9483:SELENBP1
uniprot id: F6VWU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

9483:PPEF1
gene id: 9483:PPEF1
uniprot id: A0A5F4VSH6
uniprot id: F7IS74
names: Similarity
messages: Belongs to the PPP phosphatase family.

9483:CDK5
gene id: 9483:CDK5
uniprot id: U3D7M9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:UCN
gene id: 9483:UCN
uniprot id: F7CU67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9483:CDH19
gene id: 9483:CDH19
uniprot id: F7IA45
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:ACER3
gene id: 9483:ACER3
uniprot id: F6XIB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9483:FEN1
gene id: 9483:FEN1
uniprot id: F7GXF8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

9483:RETN
gene id: 9483:RETN
uniprot id: A0A8I3W9M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

9483:KDELR2
gene id: 9483:KDELR2
uniprot id: A0A5F4W9W6
uniprot id: F7BPN6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SPRY2
gene id: 9483:SPRY2
uniprot id: F7GUB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: ruffle membrane

9483:SLC20A1
gene id: 9483:SLC20A1
uniprot id: F7BSK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

9483:AHSA1
gene id: 9483:AHSA1
uniprot id: A0A2R8N8T2
names: Similarity
messages: Belongs to the AHA1 family.

9483:MTMR3
gene id: 9483:MTMR3
uniprot id: U3CIK9
uniprot id: U3DCM4
uniprot id: U3EY99
uniprot id: U3FL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9483:PPP1R10
gene id: 9483:PPP1R10
uniprot id: F7C1C2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

9483:LOC100406056
gene id: 9483:LOC100406056
uniprot id: A0A5F4VVT1
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9483:FOXJ3
gene id: 9483:FOXJ3
uniprot id: U3BLV8
names: Subcellular Location Annotation
messages: Nucleus

9483:EID2B
gene id: 9483:EID2B
uniprot id: F7IT55
names: Subcellular Location Annotation
messages: Nucleus

9483:FYTTD1
gene id: 9483:FYTTD1
uniprot id: F7D7P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9483:LOC100391740
gene id: 9483:LOC100391740
uniprot id: B0VX98
names: Subcellular Location Annotation
messages: Membrane

9483:FAN1
gene id: 9483:FAN1
uniprot id: U3DBA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

9483:PTGES3
gene id: 9483:PTGES3
uniprot id: A0A2R8MSN2
uniprot id: F7C8H0
uniprot id: F7CND0
uniprot id: U3BK01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

9483:LOC100404148
gene id: 9483:LOC100404148
uniprot id: F6TFX6
names: Similarity
messages: Belongs to the actin family.

9483:HSD17B6
gene id: 9483:HSD17B6
uniprot id: F6TYQ7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:LLPH
gene id: 9483:LLPH
uniprot id: U3D8R7
names: Similarity
messages: Belongs to the learning-associated protein family.

9483:TMEM35B
gene id: 9483:TMEM35B
uniprot id: U3CP76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9483:MIEF1
gene id: 9483:MIEF1
uniprot id: U3EDQ7
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9483:GOLM1
gene id: 9483:GOLM1
uniprot id: U3CE44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9483:PARP16
gene id: 9483:PARP16
uniprot id: A0A5K1VSM5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:LIAS
gene id: 9483:LIAS
uniprot id: F6ZHY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

9483:KPNA1
gene id: 9483:KPNA1
uniprot id: F7HUV4
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9483:PIGP
gene id: 9483:PIGP
uniprot id: F6WQP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

9483:DOCK3
gene id: 9483:DOCK3
uniprot id: U3FQQ1
names: Similarity
messages: Belongs to the DOCK family.

9483:LOC100406557
gene id: 9483:LOC100406557
uniprot id: A0A8I3WMT9
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9483:RAP1GDS1
gene id: 9483:RAP1GDS1
uniprot id: A0A5K1VHP6
uniprot id: U3FS21
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: cytosol

9483:LOC100414136
gene id: 9483:LOC100414136
uniprot id: F6VLK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9483:TXNDC5
gene id: 9483:TXNDC5
uniprot id: U3FIT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9483:PUS7L
gene id: 9483:PUS7L
uniprot id: A0A8I3WK96
uniprot id: F6S2V2
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9483:LOC100394098
gene id: 9483:LOC100394098
uniprot id: F7HDB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PBX1
gene id: 9483:PBX1
uniprot id: F7IPP8
uniprot id: U3CS37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9483:CDK5R1
gene id: 9483:CDK5R1
uniprot id: F7DFC5
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

9483:CCNC
gene id: 9483:CCNC
uniprot id: A0A2R8N5B0
uniprot id: F7ING0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
messages: Nucleus

9483:GLMP
gene id: 9483:GLMP
uniprot id: A0A8I3XF97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9483:LOC100389040
gene id: 9483:LOC100389040
uniprot id: U3FDP9
names: Similarity
messages: Belongs to the copine family.

9483:SLC35F1
gene id: 9483:SLC35F1
uniprot id: U3F1T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9483:C5H17orf62
gene id: 9483:C5H17orf62
uniprot id: A0A2R8N184
uniprot id: F6SWT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:COPS2
gene id: 9483:COPS2
uniprot id: F7HZK4
uniprot id: U3DFN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

9483:ELAVL3
gene id: 9483:ELAVL3
uniprot id: F6VAA6
names: Similarity
messages: Belongs to the RRM elav family.

9483:CMTM7
gene id: 9483:CMTM7
uniprot id: F7DDN2
uniprot id: U3BY43
names: Subcellular Location Annotation
messages: Membrane

9483:B4GALT3
gene id: 9483:B4GALT3
uniprot id: U3D0P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9483:TIGD2
gene id: 9483:TIGD2
uniprot id: U3AZP8
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100406515
gene id: 9483:LOC100406515
uniprot id: A0A2R8M9X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SNX7
gene id: 9483:SNX7
uniprot id: A0A8J8YIN2
names: Similarity
messages: Belongs to the sorting nexin family.

9483:GRK5
gene id: 9483:GRK5
uniprot id: U3C8T5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9483:MS4A7
gene id: 9483:MS4A7
uniprot id: A0A2R8P8W6
uniprot id: F6V8V9
names: Similarity
messages: Belongs to the MS4A family.

9483:NR2C1
gene id: 9483:NR2C1
uniprot id: U3ECK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9483:NSMCE4A
gene id: 9483:NSMCE4A
uniprot id: F7HV64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

9483:LUC7L
gene id: 9483:LUC7L
uniprot id: A0A5F4VZW7
uniprot id: B0VX80
names: Similarity
messages: Belongs to the Luc7 family.

9483:HEATR1
gene id: 9483:HEATR1
uniprot id: F7HGG5
uniprot id: U3CG93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9483:NEUROD2
gene id: 9483:NEUROD2
uniprot id: F7ILB4
names: Subcellular Location Annotation
messages: Nucleus

9483:CFAP36
gene id: 9483:CFAP36
uniprot id: U3BW12
uniprot id: U3DT51
names: Similarity
messages: Belongs to the CFAP36 family.

9483:SNX25
gene id: 9483:SNX25
uniprot id: U3FLC2
names: Similarity
messages: Belongs to the sorting nexin family.

9483:TMEM167B
gene id: 9483:TMEM167B
uniprot id: A0A2R8PCV5
uniprot id: F6UZC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:NDFIP1
gene id: 9483:NDFIP1
uniprot id: U3FXR9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9483:DUS3L
gene id: 9483:DUS3L
uniprot id: F7I107
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

9483:IRGQ
gene id: 9483:IRGQ
uniprot id: U3CLC6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9483:AP3S2
gene id: 9483:AP3S2
uniprot id: U3FIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9483:FAM20B
gene id: 9483:FAM20B
uniprot id: U3BA28
names: Similarity
messages: Belongs to the FAM20 family.

9483:NOTUM
gene id: 9483:NOTUM
uniprot id: F6T367
names: Similarity
messages: Belongs to the pectinacetylesterase family. Notum subfamily.

9483:LOC100402270
gene id: 9483:LOC100402270
uniprot id: F7HA83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SLC19A1
gene id: 9483:SLC19A1
uniprot id: U3F367
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: Transporter that mediates the import of reduced folates.

9483:TRPM3
gene id: 9483:TRPM3
uniprot id: F7IBI8
uniprot id: F7IDP9
uniprot id: U3CRR3
names: Subcellular Location Annotation
messages: Membrane

9483:MOXD1
gene id: 9483:MOXD1
uniprot id: B0KWA2
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9483:CERS4
gene id: 9483:CERS4
uniprot id: F6SFF2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9483:NDST1
gene id: 9483:NDST1
uniprot id: F7HGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9483:EIF2B5
gene id: 9483:EIF2B5
uniprot id: U3B2E3
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9483:NAA35
gene id: 9483:NAA35
uniprot id: F6SM26
uniprot id: U3CWU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9483:CDH12
gene id: 9483:CDH12
uniprot id: U3EPZ9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:CDH5
gene id: 9483:CDH5
uniprot id: A0A8J8XM80
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Membrane

9483:LOC100400052
gene id: 9483:LOC100400052
uniprot id: F6UZE5
names: Subcellular Location Annotation
messages: Nucleus

9483:NFX1
gene id: 9483:NFX1
uniprot id: U3E8G5
uniprot id: U3EIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9483:MON2
gene id: 9483:MON2
uniprot id: A0A5K1UEK4
uniprot id: U3DBM1
uniprot id: U3DXG9
names: Similarity
messages: Belongs to the MON2 family.

9483:EMC8
gene id: 9483:EMC8
uniprot id: A0A8I3W6A1
uniprot id: F7IA18
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9483:TMOD1
gene id: 9483:TMOD1
uniprot id: F6ZR03
names: Subcellular Location Annotation
messages: cytoskeleton

9483:ODF1
gene id: 9483:ODF1
uniprot id: A0A8I3W4R6
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9483:KCNH7
gene id: 9483:KCNH7
uniprot id: A0A2R8MVL6
names: Subcellular Location Annotation
messages: Membrane

9483:TSPAN31
gene id: 9483:TSPAN31
uniprot id: F7GXR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:DYNLRB1
gene id: 9483:DYNLRB1
uniprot id: F7IQZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9483:OR2AG2
gene id: 9483:OR2AG2
uniprot id: A0A5F4WKZ5
names: Subcellular Location Annotation
messages: Membrane

9483:SLC7A14
gene id: 9483:SLC7A14
uniprot id: F6W919
names: Subcellular Location Annotation
messages: Membrane

9483:PPP1R1B
gene id: 9483:PPP1R1B
uniprot id: A5X4B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein phosphatase inhibitor 1 family.
messages: Cytoplasm
messages: Inhibitor of protein-phosphatase 1.

9483:ATF4
gene id: 9483:ATF4
uniprot id: H9KVU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9483:FUT7
gene id: 9483:FUT7
uniprot id: F7I6C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9483:GPN3
gene id: 9483:GPN3
uniprot id: F7IHF8
uniprot id: U3CW13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9483:RPS23
gene id: 9483:RPS23
uniprot id: F7H6F1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9483:LYRM1
gene id: 9483:LYRM1
uniprot id: F6RTD1
names: Similarity
messages: Belongs to the complex I LYR family.

9483:DPAGT1
gene id: 9483:DPAGT1
uniprot id: F6VZ52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:AP2M1
gene id: 9483:AP2M1
uniprot id: F7F7R2
uniprot id: F7FLF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9483:BMP2
gene id: 9483:BMP2
uniprot id: F7G4N4
names: Similarity
messages: Belongs to the TGF-beta family.

9483:PSMA3
gene id: 9483:PSMA3
uniprot id: F7IS34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:UPK1B
gene id: 9483:UPK1B
uniprot id: F7BN59
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

9483:PEPD
gene id: 9483:PEPD
uniprot id: F6V2W6
uniprot id: F6XAG3
names: Similarity
messages: Belongs to the peptidase M24B family.

9483:SGCD
gene id: 9483:SGCD
uniprot id: F6WJI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9483:GNG4
gene id: 9483:GNG4
uniprot id: F6QSV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:PAX3
gene id: 9483:PAX3
uniprot id: F7BBQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9483:TOLLIP
gene id: 9483:TOLLIP
uniprot id: F6PGK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9483:ATG101
gene id: 9483:ATG101
uniprot id: F6SXY0
names: Similarity
messages: Belongs to the ATG101 family.

9483:NAT9
gene id: 9483:NAT9
uniprot id: F7CWS6
uniprot id: U3ECW1
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

9483:MRPS33
gene id: 9483:MRPS33
uniprot id: F6QIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9483:MECOM
gene id: 9483:MECOM
uniprot id: F6SYP4
uniprot id: F6WQ32
uniprot id: U3DP30
names: Subcellular Location Annotation
messages: Nucleus

9483:VWC2L
gene id: 9483:VWC2L
uniprot id: F6TJC5
names: Subcellular Location Annotation
messages: Synapse

9483:POLR3D
gene id: 9483:POLR3D
uniprot id: U3FRN9
names: Subcellular Location Annotation
messages: Nucleus

9483:GRK7
gene id: 9483:GRK7
uniprot id: F7DUK2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9483:STRN3
gene id: 9483:STRN3
uniprot id: F7I8F1
uniprot id: U3FCL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9483:LOC108590303
gene id: 9483:LOC108590303
uniprot id: F6S7T1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9483:TRIM38
gene id: 9483:TRIM38
uniprot id: F7GAP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:DNAJC18
gene id: 9483:DNAJC18
uniprot id: F7CFT4
names: Subcellular Location Annotation
messages: Membrane

9483:AMT
gene id: 9483:AMT
uniprot id: F6PIE6
uniprot id: U3DTA9
uniprot id: U3F3F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9483:NEMP2
gene id: 9483:NEMP2
uniprot id: F7IFN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9483:SIX6
gene id: 9483:SIX6
uniprot id: F7IFQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

9483:LRRC14
gene id: 9483:LRRC14
uniprot id: F6UHL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRAME family. LRRC14 subfamily.
messages: Cytoplasm

9483:SOAT2
gene id: 9483:SOAT2
uniprot id: F6T271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:TUBA8
gene id: 9483:TUBA8
uniprot id: U3EB75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9483:LOC100415308
gene id: 9483:LOC100415308
uniprot id: J9QRH9
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9483:RPLP2
gene id: 9483:RPLP2
uniprot id: F6U184
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9483:PPP1R12C
gene id: 9483:PPP1R12C
uniprot id: A0A5K1U5Q7
uniprot id: H9KXM9
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9483:CYP2J2
gene id: 9483:CYP2J2
uniprot id: A0A1P8NQJ2
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:GREM2
gene id: 9483:GREM2
uniprot id: F7IL92
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:HM13
gene id: 9483:HM13
uniprot id: A0A8I3W7T5
uniprot id: F7IKY1
uniprot id: U3DHT5
uniprot id: U3FNG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9483:IRF6
gene id: 9483:IRF6
uniprot id: F7E8C9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:FOXP1
gene id: 9483:FOXP1
uniprot id: A0A8I3W5Y5
uniprot id: F7FAP4
uniprot id: F7FPV6
uniprot id: U3FVN3
names: Subcellular Location Annotation
messages: Nucleus

9483:SPTSSB
gene id: 9483:SPTSSB
uniprot id: F7FGE6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:SPOCK3
gene id: 9483:SPOCK3
uniprot id: F7HYW9
uniprot id: U3D3K8
uniprot id: U3EWV3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:GPR137
gene id: 9483:GPR137
uniprot id: F6SKA0
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9483:TLR9
gene id: 9483:TLR9
uniprot id: F7HZH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9483:TOB1
gene id: 9483:TOB1
uniprot id: F7FBT1
names: Similarity
messages: Belongs to the BTG family.

9483:ICAM1
gene id: 9483:ICAM1
uniprot id: U3B8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9483:CPN1
gene id: 9483:CPN1
uniprot id: F7ICG5
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:CIBAR1
gene id: 9483:CIBAR1
uniprot id: U3BW05
uniprot id: U3EI36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole
messages: cilium basal body

9483:TP63
gene id: 9483:TP63
uniprot id: A0A2R8P0K0
uniprot id: F7I720
uniprot id: F7I9D3
uniprot id: F7IGK5
uniprot id: U3E412
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Nucleus

9483:LOC100400493
gene id: 9483:LOC100400493
uniprot id: F7IFF1
names: Subcellular Location Annotation
messages: Nucleus

9483:BRMS1
gene id: 9483:BRMS1
uniprot id: F7ISX8
names: Subcellular Location Annotation
messages: Nucleus

9483:DTX2
gene id: 9483:DTX2
uniprot id: F7FQK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9483:TEF
gene id: 9483:TEF
uniprot id: F7HNV2
uniprot id: F7I370
uniprot id: U3FVL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9483:MFAP3L
gene id: 9483:MFAP3L
uniprot id: A0A8I3XAW5
uniprot id: U3D9Q3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:CDC42EP3
gene id: 9483:CDC42EP3
uniprot id: F6VXN1
uniprot id: U3BCL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9483:CENPT
gene id: 9483:CENPT
uniprot id: U3DEZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

9483:LOC103792189
gene id: 9483:LOC103792189
uniprot id: A0A2R8MUI6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:NR3C1
gene id: 9483:NR3C1
uniprot id: A0A6D5HP83
uniprot id: Q6XLJ0
uniprot id: U3EM87
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required.
messages: Cytoplasm
messages: Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1 and TGFB1I1. Interacts with NCOA1. Interacts with NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1. Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion. Interacts with CIART. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with GRIP1. Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE). Directly interacts with PNRC2 to attract and form a complex with UPF1 and DCP1A; the interaction leads to rapid mRNA degradation. Interacts with GSK3B. Interacts with FNIP1 and FNIP2. Interacts (via C-terminus) with HNRNPU (via C-terminus). Interacts with MCM3AP (By similarity). Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (By similarity). In the absence of hormonal ligand, interacts with TACC1 (By similarity).
messages: Increased proteasome-mediated degradation in response to glucocorticoids.
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Phosphorylation at Ser-211 increases transcriptional activity. Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity. Phosphorylation at Ser-404 may protect from glucocorticoid-induced apoptosis. Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation. May be dephosphorylated by PPP5C, attenuates NR3C1 action.
messages: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.
messages: Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity. Sumoylation at Lys-703 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWDD3-dependent manner.
messages: Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
messages: Within the infant and adult hippocampal formation, highest expression observed in the DG granule cell layer with moderate levels in the DG hilus, the CA2-CA4 pyramidal cell layer and the proximal part of the CA1 pyramidal cell layer. Moderate to high expression levels found in the presubiculum and in its' superficial layers. Weak but specific expression detected throughout the entire corticle mantle. In the amygdala, moderate levels were detected in the lateral, central and medial nuclei. Moderate expression levels were present in the PVNh alongside the third ventricle.
messages: centrosome
messages: spindle

9483:POLR3H
gene id: 9483:POLR3H
uniprot id: F7I682
uniprot id: U3EH11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

9483:POLR2C
gene id: 9483:POLR2C
uniprot id: F6ZTF7
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9483:ELOVL4
gene id: 9483:ELOVL4
uniprot id: F7HHW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9483:CDC5L
gene id: 9483:CDC5L
uniprot id: F7ISF5
uniprot id: U3F3N0
names: Similarity
messages: Belongs to the CEF1 family.

9483:DTNBP1
gene id: 9483:DTNBP1
uniprot id: U3BED2
names: Similarity
messages: Belongs to the dysbindin family.

9483:RXRG
gene id: 9483:RXRG
uniprot id: U3FF43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9483:CNRIP1
gene id: 9483:CNRIP1
uniprot id: F7F7F9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9483:MPC2
gene id: 9483:MPC2
uniprot id: F7ICP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9483:GNMT
gene id: 9483:GNMT
uniprot id: F7I607
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

9483:PPP1CB
gene id: 9483:PPP1CB
uniprot id: F6V3B9
uniprot id: U3DD84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

9483:SART3
gene id: 9483:SART3
uniprot id: U3BLG8
names: Subcellular Location Annotation
messages: nucleoplasm

9483:CRISP3
gene id: 9483:CRISP3
uniprot id: A0A2R8P9Z9
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TBPL1
gene id: 9483:TBPL1
uniprot id: F7HLY7
uniprot id: U3DHA7
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

9483:LOC100411827
gene id: 9483:LOC100411827
uniprot id: A0A2R8P9R1
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9483:VEZT
gene id: 9483:VEZT
uniprot id: A0A8I3W6K8
uniprot id: F7I393
uniprot id: U3BY21
uniprot id: U3DX34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9483:TMEM201
gene id: 9483:TMEM201
uniprot id: U3F5I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Membrane
messages: Nucleus inner membrane

9483:OLFM2
gene id: 9483:OLFM2
uniprot id: A0A2R8PDX8
uniprot id: U3DKW8
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9483:PGK1
gene id: 9483:PGK1
uniprot id: F7GSF5
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9483:RPL17
gene id: 9483:RPL17
uniprot id: F6Q3N9
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9483:RMI1
gene id: 9483:RMI1
uniprot id: F6R6A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9483:TLCD1
gene id: 9483:TLCD1
uniprot id: F7EJ17
names: Subcellular Location Annotation
messages: Membrane

9483:API5
gene id: 9483:API5
uniprot id: A0A5K1VKE6
uniprot id: A0A8J8XXQ3
uniprot id: F7DIH2
names: Similarity
messages: Belongs to the API5 family.

9483:USP9X
gene id: 9483:USP9X
uniprot id: U3DEZ6
uniprot id: U3F1D6
uniprot id: U3FD93
names: Similarity
messages: Belongs to the peptidase C19 family.

9483:DCPS
gene id: 9483:DCPS
uniprot id: U3B9C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

9483:DPP4
gene id: 9483:DPP4
uniprot id: F7IHU4
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9483:SLC15A1
gene id: 9483:SLC15A1
uniprot id: F7IDU9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9483:ADIPOR1
gene id: 9483:ADIPOR1
uniprot id: U3E4L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9483:FAM114A2
gene id: 9483:FAM114A2
uniprot id: F7HN26
uniprot id: U3FMF4
names: Similarity
messages: Belongs to the FAM114 family.

9483:DDAH1
gene id: 9483:DDAH1
uniprot id: F7B3R1
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9483:KLRK1
gene id: 9483:KLRK1
uniprot id: A4GHD0
uniprot id: A4GHD1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:ABRACL
gene id: 9483:ABRACL
uniprot id: F7II35
names: Similarity
messages: Belongs to the costars family.

9483:TXNL4A
gene id: 9483:TXNL4A
uniprot id: A0A8I4A2K8
uniprot id: U3CQA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9483:MRFAP1L1
gene id: 9483:MRFAP1L1
uniprot id: A0A2R8MXD9
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9483:TRIM36
gene id: 9483:TRIM36
uniprot id: A0A2R8MGU8
uniprot id: F7GT52
names: Subcellular Location Annotation
names: Subunit
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: cytoskeleton

9483:ALG5
gene id: 9483:ALG5
uniprot id: A0A8I3WIV8
uniprot id: A0A8I3WLK3
uniprot id: F6U339
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9483:MRPS26
gene id: 9483:MRPS26
uniprot id: U3CMR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9483:LIN7A
gene id: 9483:LIN7A
uniprot id: U3CNL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9483:LOC100386303
gene id: 9483:LOC100386303
uniprot id: F6ZLL0
names: Subcellular Location Annotation
messages: nucleolus

9483:GADD45G
gene id: 9483:GADD45G
uniprot id: F7HV04
names: Similarity
messages: Belongs to the GADD45 family.

9483:P2RY11
gene id: 9483:P2RY11
uniprot id: F7HZ21
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:BCAP29
gene id: 9483:BCAP29
uniprot id: F6RHI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9483:CRP
gene id: 9483:CRP
uniprot id: F7IB03
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:IPO7
gene id: 9483:IPO7
uniprot id: F6PKJ8
names: Subcellular Location Annotation
messages: Cytoplasm

9483:MTHFD1
gene id: 9483:MTHFD1
uniprot id: U3FKL3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9483:LOC100394045
gene id: 9483:LOC100394045
uniprot id: F7DWU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CCND2
gene id: 9483:CCND2
uniprot id: F7I947
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9483:TRAF1
gene id: 9483:TRAF1
uniprot id: F7FL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9483:TRAPPC6B
gene id: 9483:TRAPPC6B
uniprot id: F6RUG6
uniprot id: U3AR63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9483:PKMYT1
gene id: 9483:PKMYT1
uniprot id: U3CWB5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:MAPK7
gene id: 9483:MAPK7
uniprot id: F7II28
uniprot id: U3BIE1
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9483:DEGS1
gene id: 9483:DEGS1
uniprot id: F7IN61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane
messages: Mitochondrion membrane

9483:RPS16
gene id: 9483:RPS16
uniprot id: F7HKF5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9483:THUMPD2
gene id: 9483:THUMPD2
uniprot id: A0A5F4W7R1
uniprot id: F7G5B3
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9483:P4HB
gene id: 9483:P4HB
uniprot id: A0A8I3WKE0
uniprot id: U3EQL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9483:ALX3
gene id: 9483:ALX3
uniprot id: F6Q403
names: Subcellular Location Annotation
messages: Nucleus

9483:POLR2G
gene id: 9483:POLR2G
uniprot id: U3DX33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

9483:VPS25
gene id: 9483:VPS25
uniprot id: U3CTP5
names: Similarity
messages: Belongs to the VPS25 family.

9483:DTD1
gene id: 9483:DTD1
uniprot id: A0A2R8N1F0
uniprot id: F7H1X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

9483:CCDC86
gene id: 9483:CCDC86
uniprot id: F6WVK6
names: Subcellular Location Annotation
messages: Nucleus

9483:NAA30
gene id: 9483:NAA30
uniprot id: U3ES56
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

9483:LUC7L2
gene id: 9483:LUC7L2
uniprot id: F6VNY9
uniprot id: F6YZF7
uniprot id: F7EI42
names: Similarity
messages: Belongs to the Luc7 family.

9483:OR2T10
gene id: 9483:OR2T10
uniprot id: F7IFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:DENR
gene id: 9483:DENR
uniprot id: U3D8H5
names: Similarity
messages: Belongs to the DENR family.

9483:TBX6
gene id: 9483:TBX6
uniprot id: F6PYQ3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:LOC100400759
gene id: 9483:LOC100400759
uniprot id: A0A2R8MD14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9483:GAP43
gene id: 9483:GAP43
uniprot id: A0A8I4A0D1
uniprot id: F6XZY9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

9483:ITM2C
gene id: 9483:ITM2C
uniprot id: F7A817
uniprot id: U3CUY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9483:BARHL1
gene id: 9483:BARHL1
uniprot id: F6U1C3
names: Subcellular Location Annotation
messages: Nucleus

9483:PSMA5
gene id: 9483:PSMA5
uniprot id: F7C3R5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:CASP2
gene id: 9483:CASP2
uniprot id: F7I2T9
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:MTM1
gene id: 9483:MTM1
uniprot id: U3BTU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

9483:BMX
gene id: 9483:BMX
uniprot id: A0A5F4VW24
uniprot id: F7A015
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

9483:LIN28A
gene id: 9483:LIN28A
uniprot id: F7I9Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

9483:CDC20B
gene id: 9483:CDC20B
uniprot id: A0A8I3VVC8
uniprot id: F7HPI6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9483:PDGFRL
gene id: 9483:PDGFRL
uniprot id: F6S969
uniprot id: U3BFP6
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Secreted

9483:RAB38
gene id: 9483:RAB38
uniprot id: F7FQR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9483:TLCD3B
gene id: 9483:TLCD3B
uniprot id: U3ERZ3
names: Subcellular Location Annotation
messages: Membrane

9483:PTGES
gene id: 9483:PTGES
uniprot id: F7BE45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9483:EAF1
gene id: 9483:EAF1
uniprot id: U3B7W2
names: Similarity
messages: Belongs to the EAF family.

9483:RPL23A
gene id: 9483:RPL23A
uniprot id: F7EJ37
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9483:LOC108593512
gene id: 9483:LOC108593512
uniprot id: A0A5F4WHU4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9483:RLN2
gene id: 9483:RLN2
uniprot id: A0A2R8MSJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

9483:AP1G1
gene id: 9483:AP1G1
uniprot id: U3EF74
uniprot id: U3FL25
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9483:AURKA
gene id: 9483:AURKA
uniprot id: A0A8I3WN83
uniprot id: F7GVV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9483:CDH11
gene id: 9483:CDH11
uniprot id: U3ESL0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:ADORA3
gene id: 9483:ADORA3
uniprot id: U3DWN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

9483:WSCD2
gene id: 9483:WSCD2
uniprot id: U3CR93
names: Similarity
messages: Belongs to the WSCD family.

9483:LOC100403489
gene id: 9483:LOC100403489
uniprot id: A0A8I3XA83
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:MRPS15
gene id: 9483:MRPS15
uniprot id: U3F4J6
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9483:ZSCAN31
gene id: 9483:ZSCAN31
uniprot id: F7HWM1
names: Subcellular Location Annotation
messages: Nucleus

9483:SLC30A5
gene id: 9483:SLC30A5
uniprot id: U3EDJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

9483:ADD3
gene id: 9483:ADD3
uniprot id: A0A5F4WKC5
uniprot id: F6TYL1
uniprot id: F7I3U9
uniprot id: U3C1U3
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9483:ETFDH
gene id: 9483:ETFDH
uniprot id: A0A5F4WDT9
uniprot id: F7I4J5
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9483:RBM5
gene id: 9483:RBM5
uniprot id: A0A8I3WFJ4
uniprot id: F6Q8G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9483:FAM3A
gene id: 9483:FAM3A
uniprot id: B0KWT8
uniprot id: U3E9S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9483:OLFR564
gene id: 9483:OLFR564
uniprot id: B0VX92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PHB2
gene id: 9483:PHB2
uniprot id: U3BL34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9483:SPRN
gene id: 9483:SPRN
uniprot id: A2BDJ5
names: Function
names: Similarity
messages: Belongs to the SPRN family.
messages: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.

9483:RPL18
gene id: 9483:RPL18
uniprot id: F6QKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Rough endoplasmic reticulum

9483:ZFPM2
gene id: 9483:ZFPM2
uniprot id: A0A5F4VRF0
uniprot id: A0A8I3WFX5
names: Subcellular Location Annotation
messages: Nucleus

9483:CSNK1A1
gene id: 9483:CSNK1A1
uniprot id: F7HFK8
uniprot id: F7HFL4
uniprot id: U3CG48
uniprot id: U3E5N8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:MMP15
gene id: 9483:MMP15
uniprot id: U3CVZ5
names: Similarity
messages: Belongs to the peptidase M10A family.

9483:VEGFD
gene id: 9483:VEGFD
uniprot id: F6VG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9483:TAF12
gene id: 9483:TAF12
uniprot id: A0A2R8MY15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9483:CNOT8
gene id: 9483:CNOT8
uniprot id: A0A8I3WG72
uniprot id: F7HP79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9483:SLC25A29
gene id: 9483:SLC25A29
uniprot id: F7HYS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:LOC100394558
gene id: 9483:LOC100394558
uniprot id: B0KW94
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated at Tyr-155 by PARP1 in presence of HPF1.
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

9483:NR4A1
gene id: 9483:NR4A1
uniprot id: U3E1S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Cytoplasm
messages: Nucleus

9483:HMGCS1
gene id: 9483:HMGCS1
uniprot id: F6UT64
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9483:XKRX
gene id: 9483:XKRX
uniprot id: A0A5K1UT75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9483:ESR2
gene id: 9483:ESR2
uniprot id: F7FAJ4
uniprot id: F7FPJ5
uniprot id: Q95ME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9483:CDCA7
gene id: 9483:CDCA7
uniprot id: F7BNL0
uniprot id: F7IND7
uniprot id: U3BCY5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:GRM8
gene id: 9483:GRM8
uniprot id: B0VXF0
uniprot id: U3D9A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9483:TAX1BP3
gene id: 9483:TAX1BP3
uniprot id: U3FIY1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9483:SAR1B
gene id: 9483:SAR1B
uniprot id: F7IHI6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9483:HTR7
gene id: 9483:HTR7
uniprot id: U3E1W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:NR1H4
gene id: 9483:NR1H4
uniprot id: A0A2R8MU47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9483:DEFB119
gene id: 9483:DEFB119
uniprot id: F7IIL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:LOC100395188
gene id: 9483:LOC100395188
uniprot id: U3C8S8
names: Similarity
messages: Belongs to the COX20 family.

9483:ELAVL4
gene id: 9483:ELAVL4
uniprot id: A0A2R8M549
uniprot id: A0A8J8Y0W4
uniprot id: F7AGG7
uniprot id: U3EU91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9483:BET1
gene id: 9483:BET1
uniprot id: A0A8I3X9Z6
uniprot id: F6ULL8
uniprot id: F6YHS9
uniprot id: U3BHD7
names: Subcellular Location Annotation
messages: Membrane

9483:TRAPPC3
gene id: 9483:TRAPPC3
uniprot id: A0A2R8NCA5
uniprot id: U3EHE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9483:LOC103788988
gene id: 9483:LOC103788988
uniprot id: A0A8I3VYN9
names: Similarity
messages: Belongs to the LCE family.

9483:VIM
gene id: 9483:VIM
uniprot id: F7BQY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
messages: Membrane
messages: Nucleus matrix
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

9483:ZNF446
gene id: 9483:ZNF446
uniprot id: A0A5F4VTG5
uniprot id: F7A0Z3
names: Subcellular Location Annotation
messages: Nucleus

9483:SERPINF1
gene id: 9483:SERPINF1
uniprot id: F6WRV2
names: Similarity
messages: Belongs to the serpin family.

9483:TSPO2
gene id: 9483:TSPO2
uniprot id: F6R8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9483:PMM1
gene id: 9483:PMM1
uniprot id: U3DRA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9483:BCL7C
gene id: 9483:BCL7C
uniprot id: U3EWT1
names: Similarity
messages: Belongs to the BCL7 family.

9483:FARS2
gene id: 9483:FARS2
uniprot id: A0A8I3W4C2
uniprot id: U3D2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9483:AQR
gene id: 9483:AQR
uniprot id: U3EN21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWF11 family.
messages: Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.
messages: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
messages: Nucleus

9483:SUPV3L1
gene id: 9483:SUPV3L1
uniprot id: F7FZQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9483:MRS2
gene id: 9483:MRS2
uniprot id: U3EQV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

9483:HCRT
gene id: 9483:HCRT
uniprot id: F6RSD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Synapse
messages: Vesicle

9483:TBX20
gene id: 9483:TBX20
uniprot id: F7HNF6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:POLR3F
gene id: 9483:POLR3F
uniprot id: A0A8I3XE62
uniprot id: F7GCJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9483:HOXA7
gene id: 9483:HOXA7
uniprot id: B0VXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:SENP6
gene id: 9483:SENP6
uniprot id: U3DNX7
uniprot id: U3F906
names: Similarity
messages: Belongs to the peptidase C48 family.

9483:NUP85
gene id: 9483:NUP85
uniprot id: F7IG61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9483:FUT4
gene id: 9483:FUT4
uniprot id: A0A8I3WR33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

9483:PAM
gene id: 9483:PAM
uniprot id: A0A8J8XJX7
uniprot id: F7HYH3
uniprot id: F7HYH8
uniprot id: F7IJS3
uniprot id: U3F7L2
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9483:TRMT2B
gene id: 9483:TRMT2B
uniprot id: U3ED13
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SNTG1
gene id: 9483:SNTG1
uniprot id: U3D7X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9483:GPATCH1
gene id: 9483:GPATCH1
uniprot id: F6ZI94
names: Similarity
messages: Belongs to the GPATCH1 family.

9483:ATG4C
gene id: 9483:ATG4C
uniprot id: U3EX12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9483:SNX19
gene id: 9483:SNX19
uniprot id: U3DV52
names: Similarity
messages: Belongs to the sorting nexin family.

9483:SYNDIG1
gene id: 9483:SYNDIG1
uniprot id: U3DIV0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9483:APOM
gene id: 9483:APOM
uniprot id: A0A5F4W6R8
uniprot id: F7HY96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9483:LOC100389294
gene id: 9483:LOC100389294
uniprot id: F7IQA8
uniprot id: U3FV47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9483:CYBRD1
gene id: 9483:CYBRD1
uniprot id: F7B047
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9483:NTS
gene id: 9483:NTS
uniprot id: F6T798
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9483:ALX1
gene id: 9483:ALX1
uniprot id: A0A8I3WN66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9483:GABARAP
gene id: 9483:GABARAP
uniprot id: F7ANW4
names: Similarity
messages: Belongs to the ATG8 family.

9483:SPOPL
gene id: 9483:SPOPL
uniprot id: F7BCH0
names: Similarity
messages: Belongs to the Tdpoz family.

9483:PIWIL2
gene id: 9483:PIWIL2
uniprot id: U3EL75
names: Similarity
messages: Belongs to the argonaute family.

9483:AMHR2
gene id: 9483:AMHR2
uniprot id: F7IKA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

9483:B4GALT4
gene id: 9483:B4GALT4
uniprot id: F6WSA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9483:HEPHL1
gene id: 9483:HEPHL1
uniprot id: F6RM70
names: Similarity
messages: Belongs to the multicopper oxidase family.

9483:SYPL2
gene id: 9483:SYPL2
uniprot id: U3E6D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9483:SIKE1
gene id: 9483:SIKE1
uniprot id: U3EVM9
names: Similarity
messages: Belongs to the SIKE family.

9483:NRP1
gene id: 9483:NRP1
uniprot id: A0A8I3VYW8
uniprot id: F6YYL6
uniprot id: F6ZZA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:FAM110A
gene id: 9483:FAM110A
uniprot id: F7I204
names: Similarity
messages: Belongs to the FAM110 family.

9483:CPEB3
gene id: 9483:CPEB3
uniprot id: A0A8I3XDC5
names: Similarity
messages: Belongs to the RRM CPEB family.

9483:ARF3
gene id: 9483:ARF3
uniprot id: U3E190
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9483:PLA2G2A
gene id: 9483:PLA2G2A
uniprot id: F7GTB5
uniprot id: U3BS74
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9483:CD8A
gene id: 9483:CD8A
uniprot id: Q3LRP5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:SLC16A1
gene id: 9483:SLC16A1
uniprot id: F7AIN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9483:CASTOR1
gene id: 9483:CASTOR1
uniprot id: F6TTG3
uniprot id: U3E167
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

9483:SLC30A9
gene id: 9483:SLC30A9
uniprot id: F7FLK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Membrane
messages: Nucleus
messages: Vesicle

9483:GGCX
gene id: 9483:GGCX
uniprot id: F7GD44
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Membrane

9483:RAD52
gene id: 9483:RAD52
uniprot id: U3D250
names: Similarity
messages: Belongs to the RAD52 family.

9483:TMEM205
gene id: 9483:TMEM205
uniprot id: F7IAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9483:IGF2BP2
gene id: 9483:IGF2BP2
uniprot id: F7H090
uniprot id: U3FIS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: P-body
messages: Stress granule

9483:MAP4K5
gene id: 9483:MAP4K5
uniprot id: U3FXV8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

9483:ACOT8
gene id: 9483:ACOT8
uniprot id: F7I0J8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9483:EXTL2
gene id: 9483:EXTL2
uniprot id: F7G1W8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:EHD4
gene id: 9483:EHD4
uniprot id: U3EPQ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9483:MZT1
gene id: 9483:MZT1
uniprot id: F7F1E1
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9483:LHX9
gene id: 9483:LHX9
uniprot id: F7I3D2
names: Subcellular Location Annotation
messages: Nucleus

9483:GABARAPL1
gene id: 9483:GABARAPL1
uniprot id: F7HVH6
names: Similarity
messages: Belongs to the ATG8 family.

9483:SLC7A6
gene id: 9483:SLC7A6
uniprot id: U3FHB9
names: Subcellular Location Annotation
messages: Membrane

9483:NUDT12
gene id: 9483:NUDT12
uniprot id: U3FFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9483:MAF
gene id: 9483:MAF
uniprot id: A0A8I3WAM3
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

9483:ARV1
gene id: 9483:ARV1
uniprot id: A0A2R8NEP4
uniprot id: F6VUR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9483:ASB11
gene id: 9483:ASB11
uniprot id: F6R7Q4
uniprot id: F6RIQ7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:DYNC1LI1
gene id: 9483:DYNC1LI1
uniprot id: U3DNE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9483:WNT5A
gene id: 9483:WNT5A
uniprot id: F7I9H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:BANF1
gene id: 9483:BANF1
uniprot id: U3DBV0
names: Subcellular Location Annotation
messages: Nucleus

9483:SPACA3
gene id: 9483:SPACA3
uniprot id: F7I955
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Interacts with ASTL.
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
messages: acrosome membrane

9483:RACK1
gene id: 9483:RACK1
uniprot id: F7ICV3
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9483:ADH7
gene id: 9483:ADH7
uniprot id: A0A5K1TXR1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9483:POLG
gene id: 9483:POLG
uniprot id: F7IMR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits.
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

9483:PIK3R3
gene id: 9483:PIK3R3
uniprot id: F7EAE6
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9483:SORBS2
gene id: 9483:SORBS2
uniprot id: F7I6I2
uniprot id: U3AZ76
names: Subcellular Location Annotation
messages: focal adhesion

9483:ACTR3
gene id: 9483:ACTR3
uniprot id: F7GST1
names: Similarity
messages: Belongs to the actin family. ARP3 subfamily.

9483:RPAP1
gene id: 9483:RPAP1
uniprot id: F7IBN4
uniprot id: U3BMA0
names: Similarity
messages: Belongs to the RPAP1 family.

9483:MRPS30
gene id: 9483:MRPS30
uniprot id: F7INF2
names: Subcellular Location Annotation
messages: Mitochondrion

9483:CMTM5
gene id: 9483:CMTM5
uniprot id: F7IGE3
names: Subcellular Location Annotation
messages: Membrane

9483:CCT4
gene id: 9483:CCT4
uniprot id: F7EYY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:COQ7
gene id: 9483:COQ7
uniprot id: F6XXM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

9483:MIXL1
gene id: 9483:MIXL1
uniprot id: F7I8Q6
names: Subcellular Location Annotation
messages: Nucleus

9483:RAD50
gene id: 9483:RAD50
uniprot id: B0KWP2
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9483:LOC100402578
gene id: 9483:LOC100402578
uniprot id: A0A8I4A3F6
uniprot id: U3D7T7
names: Subcellular Location Annotation
messages: Nucleus

9483:TSPAN12
gene id: 9483:TSPAN12
uniprot id: U3F063
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:HADH
gene id: 9483:HADH
uniprot id: U3ERY1
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9483:CA14
gene id: 9483:CA14
uniprot id: F7IC13
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9483:GJD2
gene id: 9483:GJD2
uniprot id: F7H014
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:LOC100395443
gene id: 9483:LOC100395443
uniprot id: U3EBQ5
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

9483:CAMK4
gene id: 9483:CAMK4
uniprot id: F7I122
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:KAT6B
gene id: 9483:KAT6B
uniprot id: A0A5F4W2A5
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9483:C4BPA
gene id: 9483:C4BPA
uniprot id: F7IKA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:IL21
gene id: 9483:IL21
uniprot id: F7I3A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9483:LOC108589342
gene id: 9483:LOC108589342
uniprot id: A0A8I3WMQ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:PTGFR
gene id: 9483:PTGFR
uniprot id: A0A2R8MHU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SH3GL3
gene id: 9483:SH3GL3
uniprot id: U3CYS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Membrane

9483:PRDX6
gene id: 9483:PRDX6
uniprot id: F7ICM8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9483:PBX3
gene id: 9483:PBX3
uniprot id: F6YSM0
uniprot id: F6ZJS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9483:EPN3
gene id: 9483:EPN3
uniprot id: F7HNB8
names: Similarity
messages: Belongs to the epsin family.

9483:SF3B1
gene id: 9483:SF3B1
uniprot id: F6R058
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

9483:LOC100414530
gene id: 9483:LOC100414530
uniprot id: A0A080YV25
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

9483:INIP
gene id: 9483:INIP
uniprot id: F7H151
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9483:MCIDAS
gene id: 9483:MCIDAS
uniprot id: F7ISU3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the geminin family.
messages: Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.
messages: Nucleus

9483:NT5DC1
gene id: 9483:NT5DC1
uniprot id: A0A2R8N7M8
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

9483:ST13
gene id: 9483:ST13
uniprot id: F7HT98
names: Similarity
messages: Belongs to the FAM10 family.

9483:HEBP2
gene id: 9483:HEBP2
uniprot id: F7HWX4
names: Similarity
messages: Belongs to the HEBP family.

9483:PPP2R2A
gene id: 9483:PPP2R2A
uniprot id: U3CQ53
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9483:MTFR1L
gene id: 9483:MTFR1L
uniprot id: A0A5F4VRV1
uniprot id: F7HLK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9483:COPS3
gene id: 9483:COPS3
uniprot id: U3DU30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN3 family.
messages: Cytoplasm
messages: Nucleus

9483:COR52P3
gene id: 9483:COR52P3
uniprot id: B0VXD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:EFS
gene id: 9483:EFS
uniprot id: U3DRH1
names: Similarity
messages: Belongs to the CAS family.

9483:GPER1
gene id: 9483:GPER1
uniprot id: F7G601
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:IFNL3
gene id: 9483:IFNL3
uniprot id: F7ACE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

9483:NDUFB6
gene id: 9483:NDUFB6
uniprot id: U3BMW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:LOC100410178
gene id: 9483:LOC100410178
uniprot id: A0A2R8MSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MOCS3
gene id: 9483:MOCS3
uniprot id: F7GUM3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9483:ALDH18A1
gene id: 9483:ALDH18A1
uniprot id: F7HR79
uniprot id: U3B9D8
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

9483:LOC100390461
gene id: 9483:LOC100390461
uniprot id: F6X0G4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:LOC100410187
gene id: 9483:LOC100410187
uniprot id: A0A2R8MSU3
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9483:PPP1R14B
gene id: 9483:PPP1R14B
uniprot id: F6Q451
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9483:ELP6
gene id: 9483:ELP6
uniprot id: A0A8J8YT58
names: Similarity
messages: Belongs to the ELP6 family.

9483:VTA1
gene id: 9483:VTA1
uniprot id: F7I3Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9483:LOC100396184
gene id: 9483:LOC100396184
uniprot id: A0A2R8NFC7
names: Similarity
messages: Belongs to the pro/parathymosin family.

9483:H1-5
gene id: 9483:H1-5
uniprot id: A0A2R8MFI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9483:AMIGO1
gene id: 9483:AMIGO1
uniprot id: F7ILS6
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

9483:CYRIA
gene id: 9483:CYRIA
uniprot id: F6ZY83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9483:JAKMIP2
gene id: 9483:JAKMIP2
uniprot id: F7GZC4
uniprot id: U3CMM4
uniprot id: U3FKA4
uniprot id: U3FPI5
names: Similarity
messages: Belongs to the JAKMIP family.

9483:CHMP3
gene id: 9483:CHMP3
uniprot id: F7GN92
names: Similarity
messages: Belongs to the SNF7 family.

9483:IBSP
gene id: 9483:IBSP
uniprot id: F7I6C9
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

9483:LOC108589416
gene id: 9483:LOC108589416
uniprot id: B0VXF6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:ELMO3
gene id: 9483:ELMO3
uniprot id: F6V8Y7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9483:RNF2
gene id: 9483:RNF2
uniprot id: F7HCB5
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

9483:PABPC4
gene id: 9483:PABPC4
uniprot id: U3CSD6
uniprot id: U3D9D9
uniprot id: U3DP34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9483:HNRNPDL
gene id: 9483:HNRNPDL
uniprot id: F6UJD1
uniprot id: U3CE03
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:SLC25A39
gene id: 9483:SLC25A39
uniprot id: F6VZN0
uniprot id: U3DW85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9483:LOC103788349
gene id: 9483:LOC103788349
uniprot id: A0A8I3W6E3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SLC8B1
gene id: 9483:SLC8B1
uniprot id: F7DZX5
uniprot id: U3B2U1
names: Subcellular Location Annotation
messages: Membrane

9483:VDAC2
gene id: 9483:VDAC2
uniprot id: F7I2M8
uniprot id: U3BRF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Mitochondrion outer membrane

9483:GPD1
gene id: 9483:GPD1
uniprot id: U3D420
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

9483:HSPB1
gene id: 9483:HSPB1
uniprot id: F7I2I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus
messages: spindle

9483:TCEANC2
gene id: 9483:TCEANC2
uniprot id: U3FF24
names: Subcellular Location Annotation
messages: Nucleus

9483:SPSB4
gene id: 9483:SPSB4
uniprot id: F7E873
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9483:IL19
gene id: 9483:IL19
uniprot id: A0A2R8MR56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9483:PDS5A
gene id: 9483:PDS5A
uniprot id: F7D9K9
names: Similarity
messages: Belongs to the PDS5 family.

9483:YARS1
gene id: 9483:YARS1
uniprot id: F6ZN82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

9483:MED13L
gene id: 9483:MED13L
uniprot id: U3BRT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:RPIA
gene id: 9483:RPIA
uniprot id: F7EL42
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9483:HBQ1
gene id: 9483:HBQ1
uniprot id: B0VX79
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.

9483:PTCD3
gene id: 9483:PTCD3
uniprot id: A0A8I3W350
uniprot id: F7DQG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9483:CYRIB
gene id: 9483:CYRIB
uniprot id: U3F8K8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9483:ADORA2A
gene id: 9483:ADORA2A
uniprot id: A0A8I3X4X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9483:CXCR2
gene id: 9483:CXCR2
uniprot id: A0A8I3XF38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:DSC3
gene id: 9483:DSC3
uniprot id: F7HXC9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9483:TOMM5
gene id: 9483:TOMM5
uniprot id: F6TDI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:WFDC12
gene id: 9483:WFDC12
uniprot id: A4K2U1
names: Function
names: Subcellular Location Annotation
messages: Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity).
messages: Secreted

9483:UBQLN1
gene id: 9483:UBQLN1
uniprot id: F7HB70
uniprot id: F7HBD5
uniprot id: U3F9Z8
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9483:SLC1A1
gene id: 9483:SLC1A1
uniprot id: F7H1G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9483:MAP7D2
gene id: 9483:MAP7D2
uniprot id: F7HHJ6
uniprot id: U3BW88
names: Similarity
messages: Belongs to the MAP7 family.

9483:ZNF330
gene id: 9483:ZNF330
uniprot id: F7IJI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

9483:LOC100398424
gene id: 9483:LOC100398424
uniprot id: A0A8I3WLK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:NTF3
gene id: 9483:NTF3
uniprot id: A0A2R8PFD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9483:SCG3
gene id: 9483:SCG3
uniprot id: A0A8I3XBG4
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: secretory vesicle membrane

9483:DBR1
gene id: 9483:DBR1
uniprot id: F6RHL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

9483:SLC25A32
gene id: 9483:SLC25A32
uniprot id: F7I546
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:MRPL50
gene id: 9483:MRPL50
uniprot id: F7I2I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9483:GOLGA5
gene id: 9483:GOLGA5
uniprot id: F6U0M8
uniprot id: U3AUC3
uniprot id: U3ENU1
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

9483:SLC35A3
gene id: 9483:SLC35A3
uniprot id: A0A8I3WA46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9483:FZD7
gene id: 9483:FZD7
uniprot id: F7I3D1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:RIN2
gene id: 9483:RIN2
uniprot id: A0A8I3WPG1
uniprot id: A0A8I4A235
uniprot id: F7FJZ0
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9483:BCAT2
gene id: 9483:BCAT2
uniprot id: F7H895
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9483:FBLN7
gene id: 9483:FBLN7
uniprot id: U3DR50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:EPHA2
gene id: 9483:EPHA2
uniprot id: F7G5T3
names: Subcellular Location Annotation
messages: Membrane

9483:XRCC3
gene id: 9483:XRCC3
uniprot id: F7IP96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

9483:ELK3
gene id: 9483:ELK3
uniprot id: U3DQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:ERG
gene id: 9483:ERG
uniprot id: A0A2R8M9X4
uniprot id: A0A2R8PEF7
uniprot id: F7F2B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:GET4
gene id: 9483:GET4
uniprot id: U3D3A4
names: Similarity
messages: Belongs to the GET4 family.

9483:TARS2
gene id: 9483:TARS2
uniprot id: F7FYX6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9483:S1PR2
gene id: 9483:S1PR2
uniprot id: F7H567
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:ADPRH
gene id: 9483:ADPRH
uniprot id: F6YNG9
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9483:PTPN1
gene id: 9483:PTPN1
uniprot id: F6SC52
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9483:PSMG2
gene id: 9483:PSMG2
uniprot id: U3DGY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9483:LMLN
gene id: 9483:LMLN
uniprot id: A0A8J8XWA4
uniprot id: F7CEP7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

9483:CACNB3
gene id: 9483:CACNB3
uniprot id: A0A2R8MDP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9483:RNF8
gene id: 9483:RNF8
uniprot id: F6YBI1
uniprot id: F6YTA4
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9483:SLC6A9
gene id: 9483:SLC6A9
uniprot id: A0A2R8NCR5
uniprot id: U3EGN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9483:SRSF2
gene id: 9483:SRSF2
uniprot id: F7IJZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

9483:SCRN3
gene id: 9483:SCRN3
uniprot id: F7HV39
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9483:SLCO2A1
gene id: 9483:SLCO2A1
uniprot id: F7IM14
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SMAGP
gene id: 9483:SMAGP
uniprot id: A0A8I3WVC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9483:BGN
gene id: 9483:BGN
uniprot id: F6SL47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: May be involved in collagen fiber assembly.
messages: extracellular matrix

9483:RRAGD
gene id: 9483:RRAGD
uniprot id: F6VSE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9483:FAM149A
gene id: 9483:FAM149A
uniprot id: U3BSE2
names: Similarity
messages: Belongs to the FAM149 family.

9483:MED31
gene id: 9483:MED31
uniprot id: F7I0Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9483:RASGRP2
gene id: 9483:RASGRP2
uniprot id: F7HIU6
names: Similarity
messages: Belongs to the RASGRP family.

9483:TRIM14
gene id: 9483:TRIM14
uniprot id: F7H1L9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:COG8
gene id: 9483:COG8
uniprot id: U3DHB4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

9483:POLR1E
gene id: 9483:POLR1E
uniprot id: U3CEZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9483:GJB4
gene id: 9483:GJB4
uniprot id: F7CTW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:OLFR599
gene id: 9483:OLFR599
uniprot id: B0VXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:NANOG
gene id: 9483:NANOG
uniprot id: F7I8S8
names: Subcellular Location Annotation
messages: Nucleus

9483:TPD52L1
gene id: 9483:TPD52L1
uniprot id: A0A2R8MNW7
uniprot id: F7H5P4
uniprot id: F7HG13
uniprot id: U3DXF7
uniprot id: U3FG21
names: Similarity
messages: Belongs to the TPD52 family.

9483:EPDR1
gene id: 9483:EPDR1
uniprot id: U3DYH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ependymin family.
messages: Binds anionic lipids and gangliosides at acidic pH.
messages: Lysosome lumen
messages: Secreted

9483:LOC100390943
gene id: 9483:LOC100390943
uniprot id: F7EHE1
names: Similarity
messages: Belongs to the PRR23 family.

9483:ZNF75A
gene id: 9483:ZNF75A
uniprot id: A0A8I3X8X8
names: Subcellular Location Annotation
messages: Nucleus

9483:CNNM4
gene id: 9483:CNNM4
uniprot id: F7I1N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9483:ACKR2
gene id: 9483:ACKR2
uniprot id: A0A5F4WH17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9483:PIK3R1
gene id: 9483:PIK3R1
uniprot id: F7IP48
uniprot id: F7IP49
uniprot id: U3ERL3
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9483:CRLS1
gene id: 9483:CRLS1
uniprot id: A0A2R8MPG3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9483:NR2F2
gene id: 9483:NR2F2
uniprot id: F7ICX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9483:HDHD3
gene id: 9483:HDHD3
uniprot id: F7DX60
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9483:SRD5A1
gene id: 9483:SRD5A1
uniprot id: A0A5F4WHZ2
uniprot id: F6XII1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9483:CRKL
gene id: 9483:CRKL
uniprot id: F7HYH0
names: Similarity
messages: Belongs to the CRK family.

9483:ACHE
gene id: 9483:ACHE
uniprot id: U3EB48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9483:RPS19BP1
gene id: 9483:RPS19BP1
uniprot id: A0A2R8M2P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

9483:TMEM176B
gene id: 9483:TMEM176B
uniprot id: U3CDT7
names: Similarity
messages: Belongs to the TMEM176 family.

9483:LOC100387657
gene id: 9483:LOC100387657
uniprot id: F7GLL2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9483:LPXN
gene id: 9483:LPXN
uniprot id: A0A2R8MHV6
uniprot id: U3FPD0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

9483:FPR3
gene id: 9483:FPR3
uniprot id: A0A2R8N2M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

9483:SZRD1
gene id: 9483:SZRD1
uniprot id: F7GHV9
uniprot id: F7GPU8
names: Similarity
messages: Belongs to the SZRD1 family.

9483:A4GALT
gene id: 9483:A4GALT
uniprot id: H9KXR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9483:SLC46A1
gene id: 9483:SLC46A1
uniprot id: A0A5F4WHR3
uniprot id: F7IQD7
names: Subcellular Location Annotation
messages: Membrane

9483:CHRNB1
gene id: 9483:CHRNB1
uniprot id: U3DF34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:PSMD11
gene id: 9483:PSMD11
uniprot id: F7HPV3
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9483:UBQLN2
gene id: 9483:UBQLN2
uniprot id: U3E4G7
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9483:ITGB6
gene id: 9483:ITGB6
uniprot id: A0A2R8MWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9483:SNX32
gene id: 9483:SNX32
uniprot id: F7F0Y1
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9483:OLFM4
gene id: 9483:OLFM4
uniprot id: F7GIR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:UGP2
gene id: 9483:UGP2
uniprot id: A0A8I3WLC0
uniprot id: F6QUM6
uniprot id: U3BG80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9483:CHST10
gene id: 9483:CHST10
uniprot id: F6WIW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:MYADM
gene id: 9483:MYADM
uniprot id: F6ZUF5
names: Subcellular Location Annotation
messages: Membrane

9483:NRM
gene id: 9483:NRM
uniprot id: F7A2F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

9483:DNER
gene id: 9483:DNER
uniprot id: F7G2V2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PTCH2
gene id: 9483:PTCH2
uniprot id: U3E0M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9483:CRH
gene id: 9483:CRH
uniprot id: F7I0T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9483:MRPL14
gene id: 9483:MRPL14
uniprot id: U3ECB1
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9483:GJB2
gene id: 9483:GJB2
uniprot id: F7HZW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:MPHOSPH10
gene id: 9483:MPHOSPH10
uniprot id: F7HJG3
uniprot id: U3DY58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9483:CPB2
gene id: 9483:CPB2
uniprot id: F6Y124
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:ADNP
gene id: 9483:ADNP
uniprot id: F7IKB9
names: Subcellular Location Annotation
messages: Nucleus

9483:TSPAN15
gene id: 9483:TSPAN15
uniprot id: F6WVU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:PDP2
gene id: 9483:PDP2
uniprot id: F6WMA3
names: Similarity
messages: Belongs to the PP2C family.

9483:C1H9orf40
gene id: 9483:C1H9orf40
uniprot id: A0A5F4W825
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

9483:GSK3B
gene id: 9483:GSK3B
uniprot id: A0A2R8M2M3
uniprot id: A0A2R8M2U0
uniprot id: F6V0J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

9483:FMC1
gene id: 9483:FMC1
uniprot id: U3FMF8
names: Similarity
messages: Belongs to the FMC1 family.

9483:RPS6KA3
gene id: 9483:RPS6KA3
uniprot id: A0A5F4W771
uniprot id: A0A5F4WM03
uniprot id: F7GWP8
uniprot id: U3D5H3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9483:CAPN5
gene id: 9483:CAPN5
uniprot id: U3D7U5
names: Similarity
messages: Belongs to the peptidase C2 family.

9483:RAP2B
gene id: 9483:RAP2B
uniprot id: F7IBL9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9483:DDX50
gene id: 9483:DDX50
uniprot id: F7I8W5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

9483:PDE4D
gene id: 9483:PDE4D
uniprot id: A0A2R8MUW7
uniprot id: F6VBV7
uniprot id: F7AQU4
uniprot id: F7B975
uniprot id: U3BNV5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:CHMP6
gene id: 9483:CHMP6
uniprot id: U3BEI2
names: Similarity
messages: Belongs to the SNF7 family.

9483:HAPLN1
gene id: 9483:HAPLN1
uniprot id: F7GR30
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:KDELR1
gene id: 9483:KDELR1
uniprot id: U3BKM7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:COX7B2
gene id: 9483:COX7B2
uniprot id: F7IFV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:KCNH5
gene id: 9483:KCNH5
uniprot id: A0A8I3WZX1
uniprot id: F7E3G0
names: Subcellular Location Annotation
messages: Membrane

9483:INO80
gene id: 9483:INO80
uniprot id: F7HPT2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9483:CSTA
gene id: 9483:CSTA
uniprot id: F7GIC1
names: Similarity
messages: Belongs to the cystatin family.

9483:KIF13A
gene id: 9483:KIF13A
uniprot id: A0A2R8MWV9
uniprot id: A0A2R8PC29
uniprot id: F6RG27
uniprot id: F6S2B2
uniprot id: U3EYE7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:CD164
gene id: 9483:CD164
uniprot id: F7HWM0
uniprot id: U3BR40
uniprot id: U3F455
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9483:SLC35A2
gene id: 9483:SLC35A2
uniprot id: A0A8I3X9V8
uniprot id: F7CK42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9483:DGUOK
gene id: 9483:DGUOK
uniprot id: F7IMI0
uniprot id: U3D9U2
names: Similarity
messages: Belongs to the DCK/DGK family.

9483:GDI1
gene id: 9483:GDI1
uniprot id: U3CX66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9483:SLC9A9
gene id: 9483:SLC9A9
uniprot id: U3BWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9483:SLC66A3
gene id: 9483:SLC66A3
uniprot id: U3FIZ5
names: Subcellular Location Annotation
messages: Membrane

9483:DEGS2
gene id: 9483:DEGS2
uniprot id: F7IM28
uniprot id: U3CEP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:IRAK2
gene id: 9483:IRAK2
uniprot id: U3F779
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9483:MTX1
gene id: 9483:MTX1
uniprot id: U3D2E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:CREBL2
gene id: 9483:CREBL2
uniprot id: A0A2R8PH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9483:DHODH
gene id: 9483:DHODH
uniprot id: F7GU02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9483:NETO1
gene id: 9483:NETO1
uniprot id: F7IEJ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:DEFA4
gene id: 9483:DEFA4
uniprot id: F6PJC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9483:RPRD1A
gene id: 9483:RPRD1A
uniprot id: F7GW04
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9483:S100A4
gene id: 9483:S100A4
uniprot id: U3F5Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9483:CD151
gene id: 9483:CD151
uniprot id: F6RX70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9483:CXCL13
gene id: 9483:CXCL13
uniprot id: A0A5F4WD53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:EPC2
gene id: 9483:EPC2
uniprot id: A0A5F4VS20
uniprot id: F7IQD8
uniprot id: U3CP32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9483:PRDM14
gene id: 9483:PRDM14
uniprot id: F7I6N5
names: Subcellular Location Annotation
messages: Nucleus

9483:GJB5
gene id: 9483:GJB5
uniprot id: F7I2A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:SESN1
gene id: 9483:SESN1
uniprot id: F7HTE0
uniprot id: U3BTQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9483:TMEM150A
gene id: 9483:TMEM150A
uniprot id: F7D6R9
uniprot id: F7FKV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

9483:PIK3CB
gene id: 9483:PIK3CB
uniprot id: F7CM33
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9483:PAXBP1
gene id: 9483:PAXBP1
uniprot id: B0VXG1
names: Similarity
messages: Belongs to the GCF family.

9483:POLH
gene id: 9483:POLH
uniprot id: F7HZ00
names: Subcellular Location Annotation
messages: Nucleus

9483:WASF3
gene id: 9483:WASF3
uniprot id: F7GRX8
uniprot id: F7GRZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9483:GMPPA
gene id: 9483:GMPPA
uniprot id: B0KWJ2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9483:FUCA1
gene id: 9483:FUCA1
uniprot id: F7HZM3
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9483:PRICKLE2
gene id: 9483:PRICKLE2
uniprot id: U3EPY0
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9483:RRH
gene id: 9483:RRH
uniprot id: F6RXG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:TSPY
gene id: 9483:TSPY
uniprot id: W8BYW5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:CSNK1G3
gene id: 9483:CSNK1G3
uniprot id: A0A8J8XS38
uniprot id: F7D479
uniprot id: F7DPL9
uniprot id: U3AVV3
uniprot id: U3E6K8
uniprot id: U3F5Z4
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9483:MIF
gene id: 9483:MIF
uniprot id: H9KWP1
names: Similarity
messages: Belongs to the MIF family.

9483:PGAP6
gene id: 9483:PGAP6
uniprot id: B0VX85
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:C22H19orf53
gene id: 9483:C22H19orf53
uniprot id: F7AA03
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9483:CHRM1
gene id: 9483:CHRM1
uniprot id: F7IPY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9483:ARHGEF6
gene id: 9483:ARHGEF6
uniprot id: A0A5F4W7Y2
uniprot id: U3DIW2
names: Subcellular Location Annotation
messages: lamellipodium

9483:SDHAF1
gene id: 9483:SDHAF1
uniprot id: A0A2R8M6Q6
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9483:LMBR1L
gene id: 9483:LMBR1L
uniprot id: U3DXH0
names: Similarity
messages: Belongs to the LIMR family.

9483:TIMP1
gene id: 9483:TIMP1
uniprot id: U3CUE7
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9483:ST6GALNAC5
gene id: 9483:ST6GALNAC5
uniprot id: U3CCQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:MICOS13
gene id: 9483:MICOS13
uniprot id: U3C9P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9483:MTX3
gene id: 9483:MTX3
uniprot id: A0A8I3X2L5
uniprot id: F7EW54
uniprot id: F7EW84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:PARN
gene id: 9483:PARN
uniprot id: U3D8R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm
messages: Nucleus

9483:MYSM1
gene id: 9483:MYSM1
uniprot id: U3D192
names: Similarity
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.

9483:CRELD1
gene id: 9483:CRELD1
uniprot id: U3CMD9
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SF3A1
gene id: 9483:SF3A1
uniprot id: F6QQU4
uniprot id: U3FGV5
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100894532
gene id: 9483:LOC100894532
uniprot id: B0VXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SRP68
gene id: 9483:SRP68
uniprot id: U3D7E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9483:AGK
gene id: 9483:AGK
uniprot id: U3CSI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9483:SYT14
gene id: 9483:SYT14
uniprot id: F7GST8
uniprot id: F7GXT6
names: Similarity
messages: Belongs to the synaptotagmin family.

9483:CEBPZ
gene id: 9483:CEBPZ
uniprot id: U3F1A1
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9483:ACAP1
gene id: 9483:ACAP1
uniprot id: F6VZY8
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9483:LOC100401782
gene id: 9483:LOC100401782
uniprot id: F7DMR1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:KCNV1
gene id: 9483:KCNV1
uniprot id: F7ARX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9483:JPH1
gene id: 9483:JPH1
uniprot id: U3CJX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9483:FAM83G
gene id: 9483:FAM83G
uniprot id: F6VWC2
uniprot id: U3BLH7
names: Similarity
messages: Belongs to the FAM83 family.

9483:GIPC2
gene id: 9483:GIPC2
uniprot id: F7CET3
names: Similarity
messages: Belongs to the GIPC family.

9483:KRT222
gene id: 9483:KRT222
uniprot id: U3EVW2
names: Similarity
messages: Belongs to the intermediate filament family.

9483:MTCH1
gene id: 9483:MTCH1
uniprot id: F7FJW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:FGF7
gene id: 9483:FGF7
uniprot id: F7IBI2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:CNIH4
gene id: 9483:CNIH4
uniprot id: F7IBF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9483:GPR17
gene id: 9483:GPR17
uniprot id: A0A5F4VVE1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:EXOC1
gene id: 9483:EXOC1
uniprot id: A0A2R8MK81
uniprot id: F6TDJ1
uniprot id: F6TEL6
uniprot id: U3BV40
uniprot id: U3DVK3
uniprot id: U3FIW4
names: Similarity
messages: Belongs to the SEC3 family.

9483:WSCD1
gene id: 9483:WSCD1
uniprot id: F7I403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

9483:SFTPC
gene id: 9483:SFTPC
uniprot id: U3EVB1
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

9483:UBIAD1
gene id: 9483:UBIAD1
uniprot id: U3EFD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9483:DHFR
gene id: 9483:DHFR
uniprot id: F7IFS4
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

9483:SLC30A1
gene id: 9483:SLC30A1
uniprot id: U3CFK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9483:DUSP6
gene id: 9483:DUSP6
uniprot id: A0A2R8MQX9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9483:RGS4
gene id: 9483:RGS4
uniprot id: F6RJK3
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

9483:GGACT
gene id: 9483:GGACT
uniprot id: A0A2R8P5K9
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

9483:PNPT1
gene id: 9483:PNPT1
uniprot id: F7GWJ1
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

9483:HOXA3
gene id: 9483:HOXA3
uniprot id: B0VXK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:LIPA
gene id: 9483:LIPA
uniprot id: F6QJ20
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:SFXN1
gene id: 9483:SFXN1
uniprot id: F7F6B4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9483:NKX3-2
gene id: 9483:NKX3-2
uniprot id: A0A2R8MAF7
names: Subcellular Location Annotation
messages: Nucleus

9483:EXOC3L1
gene id: 9483:EXOC3L1
uniprot id: F7AR70
names: Similarity
messages: Belongs to the SEC6 family.

9483:LOC100406262
gene id: 9483:LOC100406262
uniprot id: B0VX86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100408124
gene id: 9483:LOC100408124
uniprot id: A0A8I3W279
names: Similarity
messages: Belongs to the LCE family.

9483:PFN1
gene id: 9483:PFN1
uniprot id: F6PID5
names: Similarity
messages: Belongs to the profilin family.

9483:STMN2
gene id: 9483:STMN2
uniprot id: U3EIE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: lamellipodium

9483:UGGT1
gene id: 9483:UGGT1
uniprot id: A0A2R8MXG2
uniprot id: U3DBX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9483:MRPL20
gene id: 9483:MRPL20
uniprot id: F7GRD9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9483:GNGT2
gene id: 9483:GNGT2
uniprot id: F6UVS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:PABPC1
gene id: 9483:PABPC1
uniprot id: F7I5L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9483:SYNDIG1L
gene id: 9483:SYNDIG1L
uniprot id: F7HKE0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9483:RNF121
gene id: 9483:RNF121
uniprot id: F6WTX2
names: Subcellular Location Annotation
messages: Membrane

9483:POPDC2
gene id: 9483:POPDC2
uniprot id: A0A2R8MF15
uniprot id: U3FG09
names: Similarity
messages: Belongs to the popeye family.

9483:ARGLU1
gene id: 9483:ARGLU1
uniprot id: F7FFN5
names: Similarity
messages: Belongs to the UPF0430 family.

9483:NADSYN1
gene id: 9483:NADSYN1
uniprot id: U3D6C7
names: Similarity
names: Subunit
messages: Homohexamer.
messages: In the C-terminal section; belongs to the NAD synthetase family.

9483:AP4S1
gene id: 9483:AP4S1
uniprot id: A0A2R8M2V0
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9483:MIS18A
gene id: 9483:MIS18A
uniprot id: F6VMZ4
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9483:TAFA1
gene id: 9483:TAFA1
uniprot id: U3CAK2
names: Similarity
messages: Belongs to the TAFA family.

9483:VPS4B
gene id: 9483:VPS4B
uniprot id: U3C4H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9483:TAGLN
gene id: 9483:TAGLN
uniprot id: F7I1Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

9483:MCL1
gene id: 9483:MCL1
uniprot id: F7GTF7
uniprot id: U3BS41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9483:SNRPD3
gene id: 9483:SNRPD3
uniprot id: F7HY39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

9483:POP5
gene id: 9483:POP5
uniprot id: F7ITC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9483:ADAM17
gene id: 9483:ADAM17
uniprot id: F7F8K4
uniprot id: U3CYN9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:TMEM186
gene id: 9483:TMEM186
uniprot id: F7IJG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9483:TEKT1
gene id: 9483:TEKT1
uniprot id: U3ESD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9483:RPP30
gene id: 9483:RPP30
uniprot id: U3FPZ8
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

9483:SF3A3
gene id: 9483:SF3A3
uniprot id: F6YRE4
names: Similarity
messages: Belongs to the SF3A3 family.

9483:GPHB5
gene id: 9483:GPHB5
uniprot id: F7HI76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9483:IYD
gene id: 9483:IYD
uniprot id: A0A8I3W347
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasmic vesicle membrane

9483:TBX15
gene id: 9483:TBX15
uniprot id: A0A2R8PB87
uniprot id: F7HZ49
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:ERLIN1
gene id: 9483:ERLIN1
uniprot id: F7GL48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9483:AQP7
gene id: 9483:AQP7
uniprot id: U3CSN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:LOC100415550
gene id: 9483:LOC100415550
uniprot id: A0A8I3W2Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9483:EIF3I
gene id: 9483:EIF3I
uniprot id: F6QB54
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

9483:MEGF11
gene id: 9483:MEGF11
uniprot id: F6VXR6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MRPS27
gene id: 9483:MRPS27
uniprot id: U3E956
names: Subcellular Location Annotation
messages: Mitochondrion

9483:EXOSC9
gene id: 9483:EXOSC9
uniprot id: F7IJD9
names: Subcellular Location Annotation
messages: Cytoplasm

9483:SDHAF4
gene id: 9483:SDHAF4
uniprot id: U3FCZ6
names: Similarity
messages: Belongs to the SDHAF4 family.

9483:PLA2G4E
gene id: 9483:PLA2G4E
uniprot id: A0A5F4VSU7
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9483:ANTKMT
gene id: 9483:ANTKMT
uniprot id: F7BBM2
uniprot id: U3DT30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9483:BZW2
gene id: 9483:BZW2
uniprot id: U3DY16
names: Similarity
messages: Belongs to the BZW family.

9483:SH3BP5
gene id: 9483:SH3BP5
uniprot id: U3CXT7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

9483:DIMT1
gene id: 9483:DIMT1
uniprot id: F6W7L4
uniprot id: U3FN76
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PPARGC1A
gene id: 9483:PPARGC1A
uniprot id: F7EFK3
uniprot id: F7I1G0
names: Subcellular Location Annotation
messages: PML body

9483:CAV3
gene id: 9483:CAV3
uniprot id: F7ILZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola
messages: sarcolemma

9483:KNG1
gene id: 9483:KNG1
uniprot id: A0A8I4A4X8
uniprot id: F7IT23
names: Subcellular Location Annotation
messages: extracellular space

9483:EBP
gene id: 9483:EBP
uniprot id: F7CM26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:WDR82
gene id: 9483:WDR82
uniprot id: F7IDG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

9483:CSMD3
gene id: 9483:CSMD3
uniprot id: F7IB61
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SLC25A36
gene id: 9483:SLC25A36
uniprot id: U3CF98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:CNNM1
gene id: 9483:CNNM1
uniprot id: A0A8I3WRG8
uniprot id: A0A8I3XE90
uniprot id: F7I103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

9483:CPXM2
gene id: 9483:CPXM2
uniprot id: U3D3F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9483:FAP
gene id: 9483:FAP
uniprot id: F7I3L2
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

9483:ADRB2
gene id: 9483:ADRB2
uniprot id: F7IE74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Membrane

9483:PCYOX1L
gene id: 9483:PCYOX1L
uniprot id: U3EWX0
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9483:ROCK1
gene id: 9483:ROCK1
uniprot id: U3DGP9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9483:STOML3
gene id: 9483:STOML3
uniprot id: U3E9Z8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9483:THOC5
gene id: 9483:THOC5
uniprot id: F6Z7F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9483:PTDSS2
gene id: 9483:PTDSS2
uniprot id: F7IDD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:LGI3
gene id: 9483:LGI3
uniprot id: U3F159
names: Subcellular Location Annotation
messages: Secreted

9483:PARVG
gene id: 9483:PARVG
uniprot id: F7H433
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9483:SI
gene id: 9483:SI
uniprot id: F7I348
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CASTOR2
gene id: 9483:CASTOR2
uniprot id: U3FDX2
names: Similarity
messages: Belongs to the GATS family.

9483:ACTL6A
gene id: 9483:ACTL6A
uniprot id: U3C2I1
names: Similarity
messages: Belongs to the actin family.

9483:PIGO
gene id: 9483:PIGO
uniprot id: U3F7U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:LOC100407742
gene id: 9483:LOC100407742
uniprot id: U3ELW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9483:PHOSPHO2
gene id: 9483:PHOSPHO2
uniprot id: F7HDN3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9483:RHBDF2
gene id: 9483:RHBDF2
uniprot id: U3BRJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

9483:RIPK2
gene id: 9483:RIPK2
uniprot id: A0A8I3WJB6
uniprot id: F7HDX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

9483:IFI27L2
gene id: 9483:IFI27L2
uniprot id: F7I565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9483:TMEM30A
gene id: 9483:TMEM30A
uniprot id: A0A5K1V9R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: secretory vesicle membrane

9483:VARS2
gene id: 9483:VARS2
uniprot id: F6SY36
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:PGM1
gene id: 9483:PGM1
uniprot id: F6VQ06
uniprot id: F7FPL5
uniprot id: U3DU43
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9483:CRYL1
gene id: 9483:CRYL1
uniprot id: F7HM70
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9483:SLC27A1
gene id: 9483:SLC27A1
uniprot id: F7B110
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:GPR3
gene id: 9483:GPR3
uniprot id: F7CGM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:MRPL9
gene id: 9483:MRPL9
uniprot id: B0KWD3
uniprot id: F7HXG7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

9483:TCAF1
gene id: 9483:TCAF1
uniprot id: F7FXG5
uniprot id: U3DVG9
names: Similarity
messages: Belongs to the TCAF family.

9483:SCN8A
gene id: 9483:SCN8A
uniprot id: A0A2R8M904
uniprot id: F7H608
uniprot id: U3D4N1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9483:TSC22D1
gene id: 9483:TSC22D1
uniprot id: A0A2R8ML41
uniprot id: A0A8I3W8C9
uniprot id: A0A8I3W8P6
uniprot id: F6TA11
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9483:OGN
gene id: 9483:OGN
uniprot id: F7INR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

9483:PDXK
gene id: 9483:PDXK
uniprot id: U3B9Q3
names: Similarity
messages: Belongs to the pyridoxine kinase family.

9483:SEC61G
gene id: 9483:SEC61G
uniprot id: A0A5F4WGJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:THYN1
gene id: 9483:THYN1
uniprot id: F7CZ83
names: Function
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9483:SMARCAD1
gene id: 9483:SMARCAD1
uniprot id: A0A5K1UF91
names: Subcellular Location Annotation
messages: Chromosome

9483:IPPK
gene id: 9483:IPPK
uniprot id: U3DLV0
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9483:LONP2
gene id: 9483:LONP2
uniprot id: A0A5F4VY50
uniprot id: A0A5F4W7F5
uniprot id: U3CTR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
messages: Belongs to the peptidase S16 family.
messages: Interacts with PEX5. Interacts with TYSND1.
messages: Peroxisome matrix

9483:NSA2
gene id: 9483:NSA2
uniprot id: F7HWF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

9483:SLC16A2
gene id: 9483:SLC16A2
uniprot id: A0A8I3WZ05
names: Subcellular Location Annotation
messages: Membrane

9483:FAM160B1
gene id: 9483:FAM160B1
uniprot id: U3DJ61
names: Similarity
messages: Belongs to the FHIP family.

9483:LOC100415579
gene id: 9483:LOC100415579
uniprot id: F6V6V9
uniprot id: F7BSA2
names: Similarity
messages: Belongs to the GAGE family.

9483:ASPN
gene id: 9483:ASPN
uniprot id: F7ILC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9483:PGM2L1
gene id: 9483:PGM2L1
uniprot id: F6UD41
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9483:FOXO4
gene id: 9483:FOXO4
uniprot id: U3E3C7
names: Subcellular Location Annotation
messages: Nucleus

9483:ACTG1
gene id: 9483:ACTG1
uniprot id: F7I0W8
names: Similarity
messages: Belongs to the actin family.

9483:FGF18
gene id: 9483:FGF18
uniprot id: A0A5F4WKI8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:EXOSC1
gene id: 9483:EXOSC1
uniprot id: F6WV46
names: Subcellular Location Annotation
messages: Cytoplasm

9483:GABRR2
gene id: 9483:GABRR2
uniprot id: A0A5F4WEQ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:POFUT2
gene id: 9483:POFUT2
uniprot id: U3DZM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 68 family.
messages: Endoplasmic reticulum

9483:LOC100405984
gene id: 9483:LOC100405984
uniprot id: A0A2R8MJ11
uniprot id: A0A5K1UBD5
uniprot id: A0A7G3HP95
uniprot id: B0KW78
uniprot id: F7AZT5
uniprot id: F7CAK4
uniprot id: F7CQQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9483:GABRA1
gene id: 9483:GABRA1
uniprot id: F7GM19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:EXOC3
gene id: 9483:EXOC3
uniprot id: U3F3N2
names: Similarity
messages: Belongs to the SEC6 family.

9483:APOBEC3G
gene id: 9483:APOBEC3G
uniprot id: C0KTR7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.
messages: Homodimer.
messages: Nucleus
messages: P-body
messages: The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.

9483:TMSB15B
gene id: 9483:TMSB15B
uniprot id: F7H1H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9483:IPO13
gene id: 9483:IPO13
uniprot id: U3FF33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

9483:PDGFRA
gene id: 9483:PDGFRA
uniprot id: F6VUA7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9483:RPN1
gene id: 9483:RPN1
uniprot id: F7FXJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9483:NEURL2
gene id: 9483:NEURL2
uniprot id: F7I9Z1
names: Subcellular Location Annotation
messages: Cytoplasm

9483:SLC2A1
gene id: 9483:SLC2A1
uniprot id: F6PYB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Photoreceptor inner segment

9483:SLITRK4
gene id: 9483:SLITRK4
uniprot id: F7I2P5
names: Similarity
messages: Belongs to the SLITRK family.

9483:HPSE
gene id: 9483:HPSE
uniprot id: A0A2R8MKT5
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

9483:BRIX1
gene id: 9483:BRIX1
uniprot id: F6YS13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9483:MMP2
gene id: 9483:MMP2
uniprot id: U3BX42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M10A family.
messages: Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.
messages: extracellular matrix

9483:LANCL1
gene id: 9483:LANCL1
uniprot id: F7EEA2
names: Similarity
messages: Belongs to the LanC-like protein family.

9483:ANXA11
gene id: 9483:ANXA11
uniprot id: U3EQA2
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9483:MRPS18A
gene id: 9483:MRPS18A
uniprot id: F7D3N2
uniprot id: U3CCR0
names: Subcellular Location Annotation
messages: Mitochondrion

9483:TSSK2
gene id: 9483:TSSK2
uniprot id: A0A2R8M342
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ACVR1
gene id: 9483:ACVR1
uniprot id: F7BQK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:NAE1
gene id: 9483:NAE1
uniprot id: U3F0P7
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

9483:CRYBB2
gene id: 9483:CRYBB2
uniprot id: U3F629
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9483:BOLA2B
gene id: 9483:BOLA2B
uniprot id: F7D8D9
names: Similarity
messages: Belongs to the BolA/IbaG family.

9483:SF3B6
gene id: 9483:SF3B6
uniprot id: F7IIW3
uniprot id: U3EW04
names: Subcellular Location Annotation
messages: Nucleus

9483:CREB3L4
gene id: 9483:CREB3L4
uniprot id: F7D041
uniprot id: U3DXB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:RAD23A
gene id: 9483:RAD23A
uniprot id: F7ISE1
uniprot id: F7ISF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9483:NDUFA3
gene id: 9483:NDUFA3
uniprot id: F6XMD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

9483:MYBL1
gene id: 9483:MYBL1
uniprot id: F7HNE8
uniprot id: F7ISB6
uniprot id: F7ISE4
names: Subcellular Location Annotation
messages: Nucleus

9483:GABRB2
gene id: 9483:GABRB2
uniprot id: F7DAV1
uniprot id: F7HJM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:NAIF1
gene id: 9483:NAIF1
uniprot id: F6Q6R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

9483:STX5
gene id: 9483:STX5
uniprot id: F7AH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9483:MAL2
gene id: 9483:MAL2
uniprot id: A0A2R8MA05
names: Subcellular Location Annotation
messages: Membrane

9483:AARS1
gene id: 9483:AARS1
uniprot id: U3C7R0
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9483:MET
gene id: 9483:MET
uniprot id: A0A8I3WZT4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:B3GAT2
gene id: 9483:B3GAT2
uniprot id: A0A5F4VXW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:FAM229B
gene id: 9483:FAM229B
uniprot id: F7IJT2
names: Similarity
messages: Belongs to the FAM229 family.

9483:CGAS
gene id: 9483:CGAS
uniprot id: F7DI49
names: Similarity
messages: Belongs to the mab-21 family.

9483:MS4A1
gene id: 9483:MS4A1
uniprot id: Q3LRP2
names: Similarity
messages: Belongs to the MS4A family.

9483:FCF1
gene id: 9483:FCF1
uniprot id: U3DZD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9483:TAS2R4
gene id: 9483:TAS2R4
uniprot id: A0A1C9ZVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: cilium membrane

9483:SAA1
gene id: 9483:SAA1
uniprot id: F6ZH70
uniprot id: U3DW52
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9483:CLIC3
gene id: 9483:CLIC3
uniprot id: F7II49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

9483:LOC100410892
gene id: 9483:LOC100410892
uniprot id: B0KWQ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM1 family.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
messages: Cytoplasm
messages: Nucleus
messages: The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.

9483:PCOLCE2
gene id: 9483:PCOLCE2
uniprot id: U3B985
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:CYP51A1
gene id: 9483:CYP51A1
uniprot id: F7CSA0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:GRAMD1A
gene id: 9483:GRAMD1A
uniprot id: F6SYN5
uniprot id: F6WX33
uniprot id: F7CNX1
uniprot id: U3E5D9
uniprot id: U3EK41
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:CFAP126
gene id: 9483:CFAP126
uniprot id: F7IFB9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9483:TGFBR1
gene id: 9483:TGFBR1
uniprot id: F7H653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:IL20
gene id: 9483:IL20
uniprot id: F6WZC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9483:GFRA1
gene id: 9483:GFRA1
uniprot id: F7DLH5
uniprot id: U3CT67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

9483:TMA7
gene id: 9483:TMA7
uniprot id: A0A8I3WZZ0
names: Similarity
messages: Belongs to the TMA7 family.

9483:VPS33A
gene id: 9483:VPS33A
uniprot id: A0A8I3VXI5
uniprot id: U3D5U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9483:CHN2
gene id: 9483:CHN2
uniprot id: F7DU99
uniprot id: U3CK98
names: Function
messages: GTPase-activating protein for p21-rac.

9483:EMP3
gene id: 9483:EMP3
uniprot id: F6PYE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9483:QRFPR
gene id: 9483:QRFPR
uniprot id: F7G2Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:NUBPL
gene id: 9483:NUBPL
uniprot id: F6X0B1
uniprot id: U3E8Z7
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

9483:AGO4
gene id: 9483:AGO4
uniprot id: U3DZG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B. Interacts with ZFP36.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9483:ECHS1
gene id: 9483:ECHS1
uniprot id: U3BLA7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9483:TRIM55
gene id: 9483:TRIM55
uniprot id: A0A5F4W5M9
uniprot id: F7I0V3
uniprot id: F7I337
uniprot id: U3DH77
uniprot id: U3E739
names: Subcellular Location Annotation
messages: Cytoplasm

9483:NDUFAF7
gene id: 9483:NDUFAF7
uniprot id: F6RB15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

9483:PLSCR4
gene id: 9483:PLSCR4
uniprot id: F6WSJ0
uniprot id: U3DVJ1
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9483:LOC100387916
gene id: 9483:LOC100387916
uniprot id: F7I8H6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9483:TIMM8A
gene id: 9483:TIMM8A
uniprot id: U3D825
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9483:TUBGCP3
gene id: 9483:TUBGCP3
uniprot id: U3DCQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9483:GPM6A
gene id: 9483:GPM6A
uniprot id: F7EFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9483:TELO2
gene id: 9483:TELO2
uniprot id: F6RHQ8
names: Similarity
messages: Belongs to the TEL2 family.

9483:PLAUR
gene id: 9483:PLAUR
uniprot id: A0A5F4WE66
uniprot id: F6QVF1
names: Function
names: Subcellular Location Annotation
messages: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
messages: Cell membrane
messages: Membrane
messages: invadopodium membrane

9483:IL17F
gene id: 9483:IL17F
uniprot id: A6N6I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-17 family.
messages: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes.
messages: Homodimer; disulfide-linked (By similarity). Heterodimer with IL17A (IL17A-IL17F) (By similarity). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule. IL17F homodimer forms predominantly complexes with IL17RC homodimer, whereas IL17A-IL17F favors complexes with IL17RA-IL17RC. IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (By similarity).
messages: Secreted

9483:LSM6
gene id: 9483:LSM6
uniprot id: U3EDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9483:LOC100400618
gene id: 9483:LOC100400618
uniprot id: U3EBN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9483:CNPY2
gene id: 9483:CNPY2
uniprot id: F7H125
names: Similarity
messages: Belongs to the canopy family.

9483:DNAH6
gene id: 9483:DNAH6
uniprot id: F6TWU1
names: Similarity
messages: Belongs to the dynein heavy chain family.

9483:LECT2
gene id: 9483:LECT2
uniprot id: A0A2R8MQ44
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9483:ZSCAN16
gene id: 9483:ZSCAN16
uniprot id: F7IFE6
names: Subcellular Location Annotation
messages: Nucleus

9483:CYLD
gene id: 9483:CYLD
uniprot id: F7CWF7
uniprot id: F7HFV9
uniprot id: U3BXL9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9483:CPA6
gene id: 9483:CPA6
uniprot id: A0A5F4WBP8
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:BCAS2
gene id: 9483:BCAS2
uniprot id: F7HWK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

9483:CCL22
gene id: 9483:CCL22
uniprot id: A0A8I3WKT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9483:CCNYL1
gene id: 9483:CCNYL1
uniprot id: F7HYI9
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9483:BEST3
gene id: 9483:BEST3
uniprot id: U3DSN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9483:ZDHHC21
gene id: 9483:ZDHHC21
uniprot id: F7HUB7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:FAM13C
gene id: 9483:FAM13C
uniprot id: U3DM92
names: Similarity
messages: Belongs to the FAM13 family.

9483:CAPRIN1
gene id: 9483:CAPRIN1
uniprot id: U3DCM5
names: Similarity
messages: Belongs to the caprin family.

9483:HDHD2
gene id: 9483:HDHD2
uniprot id: F7HWM7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9483:POLG2
gene id: 9483:POLG2
uniprot id: F7F7L7
names: Subcellular Location Annotation
messages: Mitochondrion

9483:SLC9A8
gene id: 9483:SLC9A8
uniprot id: F6PN51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9483:SLC28A2
gene id: 9483:SLC28A2
uniprot id: A0A8I3ZZF4
uniprot id: F7GNR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9483:SLC25A25
gene id: 9483:SLC25A25
uniprot id: A0A5K1TZ61
uniprot id: F6Y5H4
uniprot id: F6YJ93
uniprot id: F6YJA1
uniprot id: U3E298
uniprot id: U3FRM1
uniprot id: U3FVU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:KLC1
gene id: 9483:KLC1
uniprot id: F7H8P3
uniprot id: F7IRQ4
uniprot id: F7IRQ7
uniprot id: U3BM97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9483:ABITRAM
gene id: 9483:ABITRAM
uniprot id: U3FJK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

9483:RIC3
gene id: 9483:RIC3
uniprot id: F6TPK5
uniprot id: U3CIL7
names: Similarity
messages: Belongs to the ric-3 family.

9483:SLC44A2
gene id: 9483:SLC44A2
uniprot id: U3EU51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9483:CDC42SE1
gene id: 9483:CDC42SE1
uniprot id: B0KWB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9483:C7H1orf52
gene id: 9483:C7H1orf52
uniprot id: U3D9T0
names: Similarity
messages: Belongs to the UPF0690 family.

9483:RAG2
gene id: 9483:RAG2
uniprot id: F7E0E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9483:GTF3C5
gene id: 9483:GTF3C5
uniprot id: U3ESU6
names: Subcellular Location Annotation
messages: Nucleus

9483:RRAGC
gene id: 9483:RRAGC
uniprot id: F6WBJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9483:SPRYD3
gene id: 9483:SPRYD3
uniprot id: U3CLM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:SPIN3
gene id: 9483:SPIN3
uniprot id: F6PV54
names: Similarity
messages: Belongs to the SPIN/STSY family.

9483:GREM1
gene id: 9483:GREM1
uniprot id: F6R9I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9483:SOX6
gene id: 9483:SOX6
uniprot id: F7I7I2
names: Subcellular Location Annotation
messages: Nucleus

9483:TMEM86A
gene id: 9483:TMEM86A
uniprot id: U3FEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9483:MCOLN2
gene id: 9483:MCOLN2
uniprot id: F6TMD9
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9483:DNM3
gene id: 9483:DNM3
uniprot id: F7HY82
uniprot id: U3EHX9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9483:ACKR1
gene id: 9483:ACKR1
uniprot id: E0XJE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

9483:ATP5F1A
gene id: 9483:ATP5F1A
uniprot id: U3EFQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9483:USP20
gene id: 9483:USP20
uniprot id: U3CPF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

9483:MRPL41
gene id: 9483:MRPL41
uniprot id: U3CV55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

9483:FAM241B
gene id: 9483:FAM241B
uniprot id: F6XHS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9483:SPTLC3
gene id: 9483:SPTLC3
uniprot id: F7ARU6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9483:SAE1
gene id: 9483:SAE1
uniprot id: F6QHC3
uniprot id: U3C0S2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9483:RNASE7
gene id: 9483:RNASE7
uniprot id: F7G5S4
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9483:CCDC124
gene id: 9483:CCDC124
uniprot id: F6URD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

9483:PGAP3
gene id: 9483:PGAP3
uniprot id: F6Y4P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

9483:LOC108587672
gene id: 9483:LOC108587672
uniprot id: F7I0E1
names: Similarity
messages: Belongs to the NAC-beta family.

9483:STK17B
gene id: 9483:STK17B
uniprot id: F7F3X9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:SCUBE3
gene id: 9483:SCUBE3
uniprot id: A0A5F4WJ90
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:MAPRE2
gene id: 9483:MAPRE2
uniprot id: A0A5F4W6S5
uniprot id: F7EAS4
uniprot id: F7EW78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
messages: cytoskeleton

9483:PAQR6
gene id: 9483:PAQR6
uniprot id: F6Y983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9483:INKA2
gene id: 9483:INKA2
uniprot id: F6U9M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9483:RDH11
gene id: 9483:RDH11
uniprot id: F7BRU6
uniprot id: U3D6T3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:LOC100386748
gene id: 9483:LOC100386748
uniprot id: F7HYF5
names: Similarity
messages: Belongs to the GAGE family.

9483:GLRB
gene id: 9483:GLRB
uniprot id: F6RHN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9483:PFDN5
gene id: 9483:PFDN5
uniprot id: F7BBE6
uniprot id: F7BTR0
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9483:PNN
gene id: 9483:PNN
uniprot id: U3BJN4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

9483:OR13J1
gene id: 9483:OR13J1
uniprot id: A0A5F4WC48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:JPH2
gene id: 9483:JPH2
uniprot id: F7EC17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9483:CDV3
gene id: 9483:CDV3
uniprot id: U3B7B9
uniprot id: U3FH07
names: Similarity
messages: Belongs to the CDV3 family.

9483:MED27
gene id: 9483:MED27
uniprot id: F6SYI8
uniprot id: F7H8C4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:PPP1CC
gene id: 9483:PPP1CC
uniprot id: U3D630
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Midbody
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

9483:PRSS36
gene id: 9483:PRSS36
uniprot id: F7I9U8
names: Function
names: Subcellular Location Annotation
messages: Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1.
messages: extracellular matrix

9483:ADGRG5
gene id: 9483:ADGRG5
uniprot id: A0A8I4A5T1
uniprot id: F6T1M6
names: Subcellular Location Annotation
messages: Membrane

9483:NPRL3
gene id: 9483:NPRL3
uniprot id: B0VX74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

9483:AGXT
gene id: 9483:AGXT
uniprot id: P31029
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the transamination between L-serine and pyruvate and weakly contributes to gluconeogenesis from the L-serine metabolism.
messages: Catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification.
messages: Homodimer.
messages: Mitochondrion matrix
messages: Peroxisome
messages: The intracellular compartmentalization of AGTX in mammalian hepatocytes is species dependent. In human and rabbit, AGTX is peroxisomal. In new world monkeys (marmoset) and rodents (rat and mouse), it is distributed approximately evenly between peroxisomes and mitochondria. In carnivores, like cat, the great majority of the enzyme is mitochondrial with only a small proportion being peroxisomal.

9483:MALL
gene id: 9483:MALL
uniprot id: U3CQA1
names: Subcellular Location Annotation
messages: Membrane

9483:ALG9
gene id: 9483:ALG9
uniprot id: F7C830
uniprot id: U3DKC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:SS18
gene id: 9483:SS18
uniprot id: U3CMU6
uniprot id: U3FL36
names: Similarity
messages: Belongs to the SS18 family.

9483:AR
gene id: 9483:AR
uniprot id: D8V0F0
uniprot id: F7GJ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9483:PPIA
gene id: 9483:PPIA
uniprot id: F6SQW1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:TRIM63
gene id: 9483:TRIM63
uniprot id: F7IA12
names: Subcellular Location Annotation
messages: Cytoplasm

9483:USP48
gene id: 9483:USP48
uniprot id: U3BS81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

9483:ERBB2
gene id: 9483:ERBB2
uniprot id: F7CBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9483:FLOT1
gene id: 9483:FLOT1
uniprot id: U3FR84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

9483:CPOX
gene id: 9483:CPOX
uniprot id: U3CYT7
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

9483:LOC100398454
gene id: 9483:LOC100398454
uniprot id: F7DDA3
uniprot id: F7I4P0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

9483:NCSTN
gene id: 9483:NCSTN
uniprot id: U3CT98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9483:EMX1
gene id: 9483:EMX1
uniprot id: A0A2R8P7U5
names: Subcellular Location Annotation
messages: Nucleus

9483:XRCC1
gene id: 9483:XRCC1
uniprot id: U3DFC4
names: Subcellular Location Annotation
messages: Nucleus

9483:PPP1R3C
gene id: 9483:PPP1R3C
uniprot id: F7GL21
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9483:PRKAB1
gene id: 9483:PRKAB1
uniprot id: F7BMG6
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9483:RPL13A
gene id: 9483:RPL13A
uniprot id: F7EY23
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

9483:SFRP2
gene id: 9483:SFRP2
uniprot id: U3CQ08
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:IL18R1
gene id: 9483:IL18R1
uniprot id: F7EMB0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9483:TIMP2
gene id: 9483:TIMP2
uniprot id: A0A5F4WLF1
names: Similarity
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

9483:INTS10
gene id: 9483:INTS10
uniprot id: A0A2R8PHP2
uniprot id: A0A5F4W2V6
uniprot id: U3EAM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

9483:ARPC2
gene id: 9483:ARPC2
uniprot id: A0A2R8MQ08
uniprot id: U3CJ54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9483:LOC100385614
gene id: 9483:LOC100385614
uniprot id: F7HKW4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9483:NSRP1
gene id: 9483:NSRP1
uniprot id: A0A8I3W236
uniprot id: F6YHK4
names: Similarity
messages: Belongs to the NSRP1 family.

9483:DDX3Y
gene id: 9483:DDX3Y
uniprot id: B8YDY8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9483:NR4A2
gene id: 9483:NR4A2
uniprot id: U3FW56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9483:OR2T4
gene id: 9483:OR2T4
uniprot id: F6TMH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SUPT6H
gene id: 9483:SUPT6H
uniprot id: U3D391
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9483:THNSL1
gene id: 9483:THNSL1
uniprot id: F7HKB5
names: Similarity
messages: Belongs to the threonine synthase family.

9483:VRK1
gene id: 9483:VRK1
uniprot id: A0A5F4W549
uniprot id: U3E880
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:FAM135B
gene id: 9483:FAM135B
uniprot id: F6UKP7
uniprot id: U3EHE2
names: Similarity
messages: Belongs to the FAM135 family.

9483:FAM13A
gene id: 9483:FAM13A
uniprot id: F7EXT0
uniprot id: F7FR29
uniprot id: F7G2B1
uniprot id: U3FMN3
names: Similarity
messages: Belongs to the FAM13 family.

9483:ANAPC5
gene id: 9483:ANAPC5
uniprot id: F7IQN6
uniprot id: U3FF52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

9483:LYPD6
gene id: 9483:LYPD6
uniprot id: F7E3Z2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:CD27
gene id: 9483:CD27
uniprot id: F6ZHZ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:HPX
gene id: 9483:HPX
uniprot id: F7I2I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

9483:IFT43
gene id: 9483:IFT43
uniprot id: F7IQR4
names: Similarity
messages: Belongs to the IFT43 family.

9483:SMNDC1
gene id: 9483:SMNDC1
uniprot id: U3F6A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body

9483:CPEB1
gene id: 9483:CPEB1
uniprot id: F7HRU4
uniprot id: U3FM09
names: Similarity
messages: Belongs to the RRM CPEB family.

9483:FABP2
gene id: 9483:FABP2
uniprot id: F7HKK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

9483:BARHL2
gene id: 9483:BARHL2
uniprot id: F7CVL1
names: Subcellular Location Annotation
messages: Nucleus

9483:RO60
gene id: 9483:RO60
uniprot id: F6ZHA8
uniprot id: U3FLM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9483:IL33
gene id: 9483:IL33
uniprot id: A0A2R8PF76
uniprot id: F6PUA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9483:CCDC65
gene id: 9483:CCDC65
uniprot id: F7IT01
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: flagellum axoneme

9483:OGFOD1
gene id: 9483:OGFOD1
uniprot id: U3C724
names: Similarity
messages: Belongs to the TPA1 family.

9483:PHAX
gene id: 9483:PHAX
uniprot id: F7DJT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

9483:SLC27A5
gene id: 9483:SLC27A5
uniprot id: A0A8I3WP13
uniprot id: F7FNP6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:PPP1R2
gene id: 9483:PPP1R2
uniprot id: F6ZFQ3
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9483:NCEH1
gene id: 9483:NCEH1
uniprot id: U3EYY4
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9483:ZFYVE16
gene id: 9483:ZFYVE16
uniprot id: U3EC92
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9483:CNEP1R1
gene id: 9483:CNEP1R1
uniprot id: A0A8I3WNI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9483:ST3GAL1
gene id: 9483:ST3GAL1
uniprot id: U3EMJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:SPRTN
gene id: 9483:SPRTN
uniprot id: U3C485
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9483:GNG7
gene id: 9483:GNG7
uniprot id: F6Z244
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:PDCD11
gene id: 9483:PDCD11
uniprot id: A0A5F4VWX1
uniprot id: F6R7C7
names: Subcellular Location Annotation
messages: nucleolus

9483:CAPN8
gene id: 9483:CAPN8
uniprot id: F6Q180
names: Similarity
messages: Belongs to the peptidase C2 family.

9483:ESRRB
gene id: 9483:ESRRB
uniprot id: F7IDY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9483:BATF
gene id: 9483:BATF
uniprot id: F7I4L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

9483:GH1P6
gene id: 9483:GH1P6
uniprot id: Q8MI74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9483:TIMM21
gene id: 9483:TIMM21
uniprot id: F7IC46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

9483:TIMM10
gene id: 9483:TIMM10
uniprot id: F6XGD1
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

9483:PREPL
gene id: 9483:PREPL
uniprot id: F7GS83
uniprot id: F7HE24
uniprot id: U3BKQ0
names: Similarity
messages: Belongs to the peptidase S9A family.

9483:KIF27
gene id: 9483:KIF27
uniprot id: F7EPL7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:SLC39A14
gene id: 9483:SLC39A14
uniprot id: A0A2R8MFK4
uniprot id: A0A2R8PE13
uniprot id: A0A8I3WME3
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100403511
gene id: 9483:LOC100403511
uniprot id: F6Y4Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9483:GPRC5B
gene id: 9483:GPRC5B
uniprot id: A0A2R8MIT7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:INPP5J
gene id: 9483:INPP5J
uniprot id: F7A8G9
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

9483:TPM1
gene id: 9483:TPM1
uniprot id: A0A8J8XPA2
uniprot id: A0A8J8YJA3
uniprot id: F6Y9T0
uniprot id: F6YS84
uniprot id: F6ZSG9
uniprot id: F7GVY3
uniprot id: U3FTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9483:SLC18B1
gene id: 9483:SLC18B1
uniprot id: A0A5F4WIM7
uniprot id: A0A8I3W283
uniprot id: F7I0V1
names: Subcellular Location Annotation
messages: Membrane

9483:SLC31A2
gene id: 9483:SLC31A2
uniprot id: U3CLW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9483:COPG1
gene id: 9483:COPG1
uniprot id: U3DTS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9483:LOC100896043
gene id: 9483:LOC100896043
uniprot id: F7D3P5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9483:FAM161A
gene id: 9483:FAM161A
uniprot id: A0A8J8Y4H3
uniprot id: F6YP42
names: Similarity
messages: Belongs to the FAM161 family.

9483:PSMB4
gene id: 9483:PSMB4
uniprot id: B0KWC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9483:ALDH3A2
gene id: 9483:ALDH3A2
uniprot id: F6TG74
uniprot id: U3ETQ5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:DNAL4
gene id: 9483:DNAL4
uniprot id: F6Q578
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9483:TMEM167A
gene id: 9483:TMEM167A
uniprot id: F7CZW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

9483:NBL1
gene id: 9483:NBL1
uniprot id: A0A8I3W5B0
uniprot id: F7HWY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9483:ELP3
gene id: 9483:ELP3
uniprot id: F6Z4B9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9483:APOA5
gene id: 9483:APOA5
uniprot id: B0KWQ9
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9483:BRF2
gene id: 9483:BRF2
uniprot id: U3FBI2
names: Similarity
messages: Belongs to the TFIIB family.

9483:SEC23A
gene id: 9483:SEC23A
uniprot id: F6VTP4
uniprot id: U3CYE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9483:ACSL6
gene id: 9483:ACSL6
uniprot id: F7H7S1
uniprot id: U3D011
uniprot id: U3DNT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

9483:PWP2
gene id: 9483:PWP2
uniprot id: A0A5F4W2D8
uniprot id: F6V9M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9483:ADAT2
gene id: 9483:ADAT2
uniprot id: U3F1L5
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

9483:KCNA6
gene id: 9483:KCNA6
uniprot id: F7IIQ4
names: Subcellular Location Annotation
messages: Membrane

9483:PHKG1
gene id: 9483:PHKG1
uniprot id: U3CUK8
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9483:CD38
gene id: 9483:CD38
uniprot id: U3CHI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane

9483:TSR1
gene id: 9483:TSR1
uniprot id: U3EBS8
names: Subcellular Location Annotation
messages: nucleolus

9483:COLGALT1
gene id: 9483:COLGALT1
uniprot id: U3BBS0
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9483:B4GALT7
gene id: 9483:B4GALT7
uniprot id: U3C8L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9483:PDHB
gene id: 9483:PDHB
uniprot id: U3DWK4
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9483:PNRC2
gene id: 9483:PNRC2
uniprot id: U3FSE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Nucleus
messages: P-body

9483:DUSP2
gene id: 9483:DUSP2
uniprot id: F7HMV7
uniprot id: U3EPC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9483:ISOC2
gene id: 9483:ISOC2
uniprot id: F7HLU9
uniprot id: U3BJN1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isochorismatase family.
messages: Cytoplasm
messages: Interacts with CDKN2A.
messages: Nucleus

9483:ASB5
gene id: 9483:ASB5
uniprot id: A0A8I3X0U2
uniprot id: U3DCC2
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:TIRAP
gene id: 9483:TIRAP
uniprot id: F6WAL1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9483:QTRT1
gene id: 9483:QTRT1
uniprot id: U3DVX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

9483:TMEM50A
gene id: 9483:TMEM50A
uniprot id: F7IKB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9483:CNOT2
gene id: 9483:CNOT2
uniprot id: F7IK01
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9483:PFKFB3
gene id: 9483:PFKFB3
uniprot id: A0A8I3W439
uniprot id: F6WMF5
uniprot id: F7INK2
uniprot id: F7INK3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9483:UBR1
gene id: 9483:UBR1
uniprot id: U3EWC6
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9483:SLC39A13
gene id: 9483:SLC39A13
uniprot id: U3FL92
names: Subcellular Location Annotation
messages: Membrane

9483:DOK2
gene id: 9483:DOK2
uniprot id: F7CQK8
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9483:UBE2F
gene id: 9483:UBE2F
uniprot id: A0A2R8MDF3
uniprot id: F7E5F0
uniprot id: F7IDH7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:ADGRF2
gene id: 9483:ADGRF2
uniprot id: A0A5F4WC74
names: Subcellular Location Annotation
messages: Membrane

9483:PARG
gene id: 9483:PARG
uniprot id: F7DP34
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9483:CCDC181
gene id: 9483:CCDC181
uniprot id: U3DQV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

9483:OTX1
gene id: 9483:OTX1
uniprot id: F7GZ10
names: Subcellular Location Annotation
messages: Nucleus

9483:PEX3
gene id: 9483:PEX3
uniprot id: U3EA46
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9483:GCDH
gene id: 9483:GCDH
uniprot id: F7IF96
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9483:TDP2
gene id: 9483:TDP2
uniprot id: F7HX74
names: Subcellular Location Annotation
messages: PML body

9483:IL18RAP
gene id: 9483:IL18RAP
uniprot id: F6X906
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9483:ADAMTS1
gene id: 9483:ADAMTS1
uniprot id: F6X3H6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:CDC42EP1
gene id: 9483:CDC42EP1
uniprot id: F7B9V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9483:CALHM5
gene id: 9483:CALHM5
uniprot id: F7IPZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9483:VAMP8
gene id: 9483:VAMP8
uniprot id: A0A8I3VZ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9483:SSX4B
gene id: 9483:SSX4B
uniprot id: A0A2R8M6L0
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

9483:NIPBL
gene id: 9483:NIPBL
uniprot id: U3D5P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9483:OTOP3
gene id: 9483:OTOP3
uniprot id: F7G708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9483:RECQL4
gene id: 9483:RECQL4
uniprot id: F7GFQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9483:NAA25
gene id: 9483:NAA25
uniprot id: F7IPZ6
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9483:TDRD7
gene id: 9483:TDRD7
uniprot id: F7HUL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

9483:CDC123
gene id: 9483:CDC123
uniprot id: U3E0T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

9483:PTPN14
gene id: 9483:PTPN14
uniprot id: A0A5F4VSV1
uniprot id: F6WSL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9483:CNTNAP1
gene id: 9483:CNTNAP1
uniprot id: U3F7V4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9483:CLTA
gene id: 9483:CLTA
uniprot id: F7CXQ1
uniprot id: F7DG30
uniprot id: F7E533
uniprot id: U3EBK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9483:ITGB3BP
gene id: 9483:ITGB3BP
uniprot id: F7A6Y2
uniprot id: U3BB95
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

9483:MRPL27
gene id: 9483:MRPL27
uniprot id: F7IG40
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9483:KCTD10
gene id: 9483:KCTD10
uniprot id: A0A5K1UDP4
uniprot id: U3E2C8
names: Similarity
messages: Belongs to the BACURD family.

9483:USP1
gene id: 9483:USP1
uniprot id: F7HWE7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:TMEM170B
gene id: 9483:TMEM170B
uniprot id: U3F5M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9483:MARCKS
gene id: 9483:MARCKS
uniprot id: F7HYZ1
names: Similarity
messages: Belongs to the MARCKS family.

9483:COCH
gene id: 9483:COCH
uniprot id: U3FT31
names: Function
messages: Plays a role in the control of cell shape and motility in the trabecular meshwork.

9483:GMNN
gene id: 9483:GMNN
uniprot id: F7IB66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9483:FAM83B
gene id: 9483:FAM83B
uniprot id: A0A5F4WLS7
names: Similarity
messages: Belongs to the FAM83 family.

9483:TMED3
gene id: 9483:TMED3
uniprot id: U3C3B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9483:NDUFB5
gene id: 9483:NDUFB5
uniprot id: F7GBY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:RTCA
gene id: 9483:RTCA
uniprot id: A0A8I3X949
uniprot id: F7H6I6
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

9483:ASB4
gene id: 9483:ASB4
uniprot id: F7GMS4
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:POLA2
gene id: 9483:POLA2
uniprot id: F6YPZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

9483:NUCB1
gene id: 9483:NUCB1
uniprot id: F7FNS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobindin family.
messages: Cytoplasm
messages: Secreted
messages: cis-Golgi network membrane

9483:ABAT
gene id: 9483:ABAT
uniprot id: U3CEZ2
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9483:FLAD1
gene id: 9483:FLAD1
uniprot id: F7IRT9
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9483:TSEN15
gene id: 9483:TSEN15
uniprot id: F7GWP4
names: Similarity
messages: Belongs to the SEN15 family.

9483:CCNH
gene id: 9483:CCNH
uniprot id: A0A2R8MAZ6
uniprot id: A0A8J8Y8G9
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9483:FKBP4
gene id: 9483:FKBP4
uniprot id: F7IS31
uniprot id: U3F7U9
names: Subcellular Location Annotation
messages: Nucleus

9483:GPRIN1
gene id: 9483:GPRIN1
uniprot id: F7CTE5
names: Function
messages: May be involved in neurite outgrowth.

9483:TTLL1
gene id: 9483:TTLL1
uniprot id: F6T1S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin polyglutamylase family.
messages: cilium basal body

9483:DHDH
gene id: 9483:DHDH
uniprot id: F7FPG8
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9483:LOC100385358
gene id: 9483:LOC100385358
uniprot id: U3FGA5
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9483:SPARCL1
gene id: 9483:SPARCL1
uniprot id: U3F1M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9483:GNA13
gene id: 9483:GNA13
uniprot id: U3EV79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9483:TMEM47
gene id: 9483:TMEM47
uniprot id: A0A2R8P179
uniprot id: U3E0Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9483:LOC100389518
gene id: 9483:LOC100389518
uniprot id: A0A2R8N9P5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9483:IDH3G
gene id: 9483:IDH3G
uniprot id: F7DIL0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9483:TMEM184B
gene id: 9483:TMEM184B
uniprot id: U3BZH9
uniprot id: U3EME4
names: Subcellular Location Annotation
messages: Membrane

9483:GPRC5A
gene id: 9483:GPRC5A
uniprot id: F7IJ74
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:HOXD13
gene id: 9483:HOXD13
uniprot id: F7GPP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9483:CPD
gene id: 9483:CPD
uniprot id: U3FTT0
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:NDUFA2
gene id: 9483:NDUFA2
uniprot id: A0A2R8N2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:CIAO2B
gene id: 9483:CIAO2B
uniprot id: F6WAM2
names: Similarity
messages: Belongs to the MIP18 family.

9483:NTHL1
gene id: 9483:NTHL1
uniprot id: U3FEL8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

9483:DDX3X
gene id: 9483:DDX3X
uniprot id: F7IPC4
uniprot id: U3BPE2
uniprot id: U3F245
names: Similarity
messages: Belongs to the DEAD box helicase family.

9483:LOC100414113
gene id: 9483:LOC100414113
uniprot id: A0A8I3WN60
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:ABHD2
gene id: 9483:ABHD2
uniprot id: U3FJQ6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9483:SLC25A44
gene id: 9483:SLC25A44
uniprot id: U3F7B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:NAPEPLD
gene id: 9483:NAPEPLD
uniprot id: U3E0R8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

9483:CLGN
gene id: 9483:CLGN
uniprot id: A0A5F4VT31
uniprot id: A0A5F4W4W5
names: Similarity
messages: Belongs to the calreticulin family.

9483:TLR8
gene id: 9483:TLR8
uniprot id: F6RY00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9483:WDR12
gene id: 9483:WDR12
uniprot id: F7D4Y2
uniprot id: U3B9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

9483:GFM1
gene id: 9483:GFM1
uniprot id: U3E9C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9483:UFM1
gene id: 9483:UFM1
uniprot id: U3DH81
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9483:CKMT2
gene id: 9483:CKMT2
uniprot id: F7G223
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9483:SYNGR3
gene id: 9483:SYNGR3
uniprot id: U3DGF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9483:FAM162A
gene id: 9483:FAM162A
uniprot id: F6VDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9483:UNG
gene id: 9483:UNG
uniprot id: F7GQH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Monomer. Interacts with FAM72A.
messages: Nucleus

9483:TSHR
gene id: 9483:TSHR
uniprot id: A0A5F4W4G7
uniprot id: F7HW35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

9483:CTLA4
gene id: 9483:CTLA4
uniprot id: A0A2R8MRX8
uniprot id: C7EPD5
uniprot id: F7BDI2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9483:RPS26
gene id: 9483:RPS26
uniprot id: A0A2R8MZE0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9483:UBE4B
gene id: 9483:UBE4B
uniprot id: F7HC69
uniprot id: F7HC77
uniprot id: U3D326
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9483:DNAJC25
gene id: 9483:DNAJC25
uniprot id: F7ESD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

9483:LOC100414245
gene id: 9483:LOC100414245
uniprot id: F6ZFU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9483:TMEM134
gene id: 9483:TMEM134
uniprot id: F6YEZ0
uniprot id: F6YF44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Membrane

9483:CCZ1
gene id: 9483:CCZ1
uniprot id: U3BMT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCZ1 family.
messages: Lysosome membrane

9483:NME5
gene id: 9483:NME5
uniprot id: F7I8N9
names: Similarity
messages: Belongs to the NDK family.

9483:TFAP2C
gene id: 9483:TFAP2C
uniprot id: U3D041
names: Similarity
messages: Belongs to the AP-2 family.

9483:PIM2
gene id: 9483:PIM2
uniprot id: F7C4B8
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9483:TARS3
gene id: 9483:TARS3
uniprot id: F7IRD8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9483:GTF2F2
gene id: 9483:GTF2F2
uniprot id: F7GSA9
uniprot id: U3CFI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

9483:CSF2
gene id: 9483:CSF2
uniprot id: B0KWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9483:KCNC2
gene id: 9483:KCNC2
uniprot id: A0A5F4W2U6
uniprot id: A0A8I4A4L2
uniprot id: F7HVC4
uniprot id: F7HVE1
uniprot id: F7HVE2
uniprot id: F7HVE3
names: Subcellular Location Annotation
messages: Membrane

9483:SLC39A3
gene id: 9483:SLC39A3
uniprot id: A0A5F4W3D1
names: Subcellular Location Annotation
messages: Membrane

9483:CORO7
gene id: 9483:CORO7
uniprot id: U3CIU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

9483:STK10
gene id: 9483:STK10
uniprot id: F7HI69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane

9483:ABHD16A
gene id: 9483:ABHD16A
uniprot id: U3E3N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

9483:CUTC
gene id: 9483:CUTC
uniprot id: U3EID7
names: Similarity
messages: Belongs to the CutC family.

9483:ACTR10
gene id: 9483:ACTR10
uniprot id: F7I3K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9483:CPNE3
gene id: 9483:CPNE3
uniprot id: F7FA36
names: Similarity
messages: Belongs to the copine family.

9483:ARL2BP
gene id: 9483:ARL2BP
uniprot id: F7C9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
messages: centrosome
messages: cilium basal body

9483:MRAP
gene id: 9483:MRAP
uniprot id: A0A8I3WIB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:TMEM230
gene id: 9483:TMEM230
uniprot id: F6UFQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9483:ALAS1
gene id: 9483:ALAS1
uniprot id: U3DYR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9483:LPCAT4
gene id: 9483:LPCAT4
uniprot id: F7G5J2
uniprot id: U3D5S4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9483:CFAP53
gene id: 9483:CFAP53
uniprot id: F7I6H9
names: Similarity
messages: Belongs to the CFAP53 family.

9483:GDPGP1
gene id: 9483:GDPGP1
uniprot id: U3C2S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9483:APPL1
gene id: 9483:APPL1
uniprot id: F7FXM1
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

9483:NMNAT3
gene id: 9483:NMNAT3
uniprot id: A0A2R8MMF5
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9483:MED1
gene id: 9483:MED1
uniprot id: U3EHB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9483:EDEM2
gene id: 9483:EDEM2
uniprot id: F6TUE0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9483:NIT2
gene id: 9483:NIT2
uniprot id: U3EDE1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9483:STING1
gene id: 9483:STING1
uniprot id: F7HWC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9483:SETD7
gene id: 9483:SETD7
uniprot id: U3AWL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9483:SLC17A3
gene id: 9483:SLC17A3
uniprot id: F7HHV4
names: Subcellular Location Annotation
messages: Membrane

9483:MPPE1
gene id: 9483:MPPE1
uniprot id: U3ERB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Interacts with GPI-anchor proteins. Interacts with TMED10.
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

9483:GLYCTK
gene id: 9483:GLYCTK
uniprot id: F7IB83
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9483:ELL3
gene id: 9483:ELL3
uniprot id: B0KWG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9483:GGPS1
gene id: 9483:GGPS1
uniprot id: A0A5F4WAA7
uniprot id: F7EFP1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9483:LOC100406470
gene id: 9483:LOC100406470
uniprot id: H9KXU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ZNF445
gene id: 9483:ZNF445
uniprot id: F7HFN5
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100386406
gene id: 9483:LOC100386406
uniprot id: A0A2R8P258
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9483:CAPN2
gene id: 9483:CAPN2
uniprot id: U3D7R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9483:UTP23
gene id: 9483:UTP23
uniprot id: F7HWG8
names: Subcellular Location Annotation
messages: nucleolus

9483:EFNB2
gene id: 9483:EFNB2
uniprot id: F7ENK8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:BMPR1A
gene id: 9483:BMPR1A
uniprot id: A0A5K1U8C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9483:LOC100388427
gene id: 9483:LOC100388427
uniprot id: F7FGL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:CA2
gene id: 9483:CA2
uniprot id: U3EKN4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9483:UBE2M
gene id: 9483:UBE2M
uniprot id: F7CFP7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:TBCB
gene id: 9483:TBCB
uniprot id: F7IEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

9483:AVL9
gene id: 9483:AVL9
uniprot id: A0A8J8YF10
uniprot id: F7B4A5
uniprot id: U3D6Q3
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

9483:LOC100386265
gene id: 9483:LOC100386265
uniprot id: A0A8I4A6I7
names: Similarity
messages: Belongs to the histone H3 family.

9483:NDUFB4
gene id: 9483:NDUFB4
uniprot id: F7HJN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:DBX1
gene id: 9483:DBX1
uniprot id: F7FA07
names: Subcellular Location Annotation
messages: Nucleus

9483:MYC
gene id: 9483:MYC
uniprot id: P49032
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity). Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (By similarity).
messages: Phosphorylated by PRKDC (By similarity). Phosphorylation at Ser-328 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. Dephosphorylation at Ser-62 by protein phosphatase 2A (PPP2CA) promotes its degradation; interaction with PPP2CA is enhanced by AMBRA1 (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).
messages: Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. Ubiquitination is counteracted by USP28 in the nucleoplasm and USP36 in the nucleolus, both interacting with of FBXW7, leading to its deubiquitination and preventing degradation. Also polyubiquitinated by the DCX(TRPC4AP) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner.
messages: nucleolus
messages: nucleoplasm

9483:LOC100401560
gene id: 9483:LOC100401560
uniprot id: A0A5F4WAW3
names: Subcellular Location Annotation
messages: Nucleus

9483:USP45
gene id: 9483:USP45
uniprot id: F7I295
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:UFC1
gene id: 9483:UFC1
uniprot id: U3BVZ1
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9483:PRXL2A
gene id: 9483:PRXL2A
uniprot id: U3FMC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

9483:LTB4R
gene id: 9483:LTB4R
uniprot id: A0A5F4W1Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:KCNJ13
gene id: 9483:KCNJ13
uniprot id: A0A5F4VRF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9483:GALNT10
gene id: 9483:GALNT10
uniprot id: U3DIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:CRY1
gene id: 9483:CRY1
uniprot id: U3F9C3
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9483:LIN7C
gene id: 9483:LIN7C
uniprot id: F7DG56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9483:LYG1
gene id: 9483:LYG1
uniprot id: F6VJX2
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

9483:UBE2L6
gene id: 9483:UBE2L6
uniprot id: A0A2R8N1M1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:SST
gene id: 9483:SST
uniprot id: F7IIT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9483:CIRBP
gene id: 9483:CIRBP
uniprot id: F7AAY5
uniprot id: F7AB55
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with EIF4G1. Associates with ribosomes.
messages: nucleoplasm

9483:INPP1
gene id: 9483:INPP1
uniprot id: F7ISD4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9483:RPL23
gene id: 9483:RPL23
uniprot id: A0A2R8PA32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9483:CXCL10
gene id: 9483:CXCL10
uniprot id: A0A2R8MWC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:ADAMTS19
gene id: 9483:ADAMTS19
uniprot id: F7GX00
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:LPCAT2
gene id: 9483:LPCAT2
uniprot id: U3C971
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9483:PEX5L
gene id: 9483:PEX5L
uniprot id: A0A2R8MJU7
uniprot id: A0A2R8P784
uniprot id: F7HHX5
uniprot id: F7HI24
uniprot id: U3D9Y9
uniprot id: U3F2J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane

9483:RPF1
gene id: 9483:RPF1
uniprot id: F7CAZ0
names: Subcellular Location Annotation
messages: nucleolus

9483:CAMK2D
gene id: 9483:CAMK2D
uniprot id: A0A2R8M8I7
uniprot id: A0A2R8MP59
uniprot id: A0A2R8PG23
uniprot id: A0A5F4W0R4
uniprot id: A0A5F4WAP1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9483:CTU1
gene id: 9483:CTU1
uniprot id: U3DVE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9483:PAX5
gene id: 9483:PAX5
uniprot id: F6SUH6
uniprot id: F6T567
names: Subcellular Location Annotation
messages: Nucleus

9483:CXCL6
gene id: 9483:CXCL6
uniprot id: A0A2R8N9E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:LOC103794241
gene id: 9483:LOC103794241
uniprot id: A0A5F4WF65
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

9483:MAT1A
gene id: 9483:MAT1A
uniprot id: F7DH88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9483:GABRD
gene id: 9483:GABRD
uniprot id: U3CNP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:PDE6G
gene id: 9483:PDE6G
uniprot id: A0A2R8MS48
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9483:BCLAF1
gene id: 9483:BCLAF1
uniprot id: U3B5H4
uniprot id: U3CYS9
uniprot id: U3F318
uniprot id: U3F882
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCLAF1/THRAP3 family.
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus

9483:NAPRT
gene id: 9483:NAPRT
uniprot id: U3F8H4
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

9483:MYT1L
gene id: 9483:MYT1L
uniprot id: A0A5F4VSN3
uniprot id: F7CCJ7
uniprot id: F7CCX3
uniprot id: U3F544
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

9483:SCO1
gene id: 9483:SCO1
uniprot id: A0A8J8Y5X2
names: Similarity
messages: Belongs to the SCO1/2 family.

9483:HAS2
gene id: 9483:HAS2
uniprot id: A0A5F4VTI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9483:FAM168B
gene id: 9483:FAM168B
uniprot id: F7GKM9
names: Similarity
messages: Belongs to the FAM168 family.

9483:FUBP1
gene id: 9483:FUBP1
uniprot id: A0A5F4W8Z2
uniprot id: A0A8I3WEM8
names: Subcellular Location Annotation
messages: Nucleus

9483:SLC2A8
gene id: 9483:SLC2A8
uniprot id: F6SK66
uniprot id: F6SUY3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9483:TGIF1
gene id: 9483:TGIF1
uniprot id: A0A8I3WAA8
uniprot id: F7E4J0
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100397481
gene id: 9483:LOC100397481
uniprot id: A0A2R8MZU2
uniprot id: A0A2R8PMJ3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9483:POLD3
gene id: 9483:POLD3
uniprot id: F7AUU9
names: Subcellular Location Annotation
messages: Nucleus

9483:PPOX
gene id: 9483:PPOX
uniprot id: F7GX92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

9483:ENTPD7
gene id: 9483:ENTPD7
uniprot id: F7IHC4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9483:IGFBP6
gene id: 9483:IGFBP6
uniprot id: F6PGT7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:LOC100398433
gene id: 9483:LOC100398433
uniprot id: F7IHC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9483:ADGRG1
gene id: 9483:ADGRG1
uniprot id: U3C7R1
uniprot id: U3EUN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

9483:KCNK4
gene id: 9483:KCNK4
uniprot id: U3FMT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9483:PSMB5
gene id: 9483:PSMB5
uniprot id: A0A8J8XYY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:C18H1orf43
gene id: 9483:C18H1orf43
uniprot id: F7HRA2
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9483:GRM1
gene id: 9483:GRM1
uniprot id: F7E693
uniprot id: F7E6E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9483:LBH
gene id: 9483:LBH
uniprot id: F7HVN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9483:POT1
gene id: 9483:POT1
uniprot id: F7FJ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

9483:DCBLD2
gene id: 9483:DCBLD2
uniprot id: A0A5K1VHP5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:AIDA
gene id: 9483:AIDA
uniprot id: U3EV57
names: Similarity
messages: Belongs to the AIDA family.

9483:RNASE1
gene id: 9483:RNASE1
uniprot id: F7GJ91
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9483:CLPTM1
gene id: 9483:CLPTM1
uniprot id: A0A5K1UW06
uniprot id: U3FUB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9483:RBBP5
gene id: 9483:RBBP5
uniprot id: U3DAP2
uniprot id: U3DM12
names: Subcellular Location Annotation
messages: Nucleus

9483:PDCD4
gene id: 9483:PDCD4
uniprot id: U3BXK1
names: Similarity
messages: Belongs to the PDCD4 family.

9483:PHOSPHO1
gene id: 9483:PHOSPHO1
uniprot id: A0A2R8MPW6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9483:SLC2A7
gene id: 9483:SLC2A7
uniprot id: F6PPF3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9483:CD68
gene id: 9483:CD68
uniprot id: U3FBS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

9483:LOC100411687
gene id: 9483:LOC100411687
uniprot id: A0A8I3X3B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ADGRG3
gene id: 9483:ADGRG3
uniprot id: F6QY45
names: Subcellular Location Annotation
messages: Membrane

9483:BBS5
gene id: 9483:BBS5
uniprot id: F7EG67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

9483:EFTUD2
gene id: 9483:EFTUD2
uniprot id: F7I888
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Nucleus

9483:MS4A5
gene id: 9483:MS4A5
uniprot id: F7BSN1
names: Similarity
messages: Belongs to the MS4A family.

9483:STXBP1
gene id: 9483:STXBP1
uniprot id: F6SYW8
uniprot id: F7IMD1
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9483:ARPC1B
gene id: 9483:ARPC1B
uniprot id: U3DX24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

9483:FES
gene id: 9483:FES
uniprot id: F7IBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

9483:PRND
gene id: 9483:PRND
uniprot id: A0A2R8MKM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

9483:ZNF449
gene id: 9483:ZNF449
uniprot id: F7IKZ3
names: Subcellular Location Annotation
messages: Nucleus

9483:VPS8
gene id: 9483:VPS8
uniprot id: U3D975
uniprot id: U3E8U3
names: Similarity
messages: Belongs to the VPS8 family.

9483:TUFM
gene id: 9483:TUFM
uniprot id: F7IMS0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9483:MAPK4
gene id: 9483:MAPK4
uniprot id: F7HUR1
uniprot id: U3ETP2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9483:TLR10
gene id: 9483:TLR10
uniprot id: F6X6W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9483:CDKN1A
gene id: 9483:CDKN1A
uniprot id: U3E394
names: Similarity
messages: Belongs to the CDI family.

9483:SLC37A2
gene id: 9483:SLC37A2
uniprot id: F7GPR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9483:SLC35D2
gene id: 9483:SLC35D2
uniprot id: F7GT05
uniprot id: F7IKP5
names: Subcellular Location Annotation
messages: Membrane

9483:STUM
gene id: 9483:STUM
uniprot id: U3DQU2
names: Subcellular Location Annotation
messages: Membrane

9483:TUBB4B
gene id: 9483:TUBB4B
uniprot id: H9KVN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9483:HMGA1
gene id: 9483:HMGA1
uniprot id: F7HUN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9483:LOC100411216
gene id: 9483:LOC100411216
uniprot id: A0A5F4WLF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:RNGTT
gene id: 9483:RNGTT
uniprot id: A0A5F4VXZ2
uniprot id: F7BIR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9483:CHRM2
gene id: 9483:CHRM2
uniprot id: F7APE0
uniprot id: U3EXJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9483:SCAND1
gene id: 9483:SCAND1
uniprot id: U3CYJ8
names: Subcellular Location Annotation
messages: Nucleus

9483:EN2
gene id: 9483:EN2
uniprot id: U3EFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

9483:KCNN2
gene id: 9483:KCNN2
uniprot id: A0A2R8P946
names: Subcellular Location Annotation
messages: Membrane

9483:LOC108593294
gene id: 9483:LOC108593294
uniprot id: A0A8I4A623
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:EXOSC2
gene id: 9483:EXOSC2
uniprot id: A0A5F4VWK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9483:LMNB1
gene id: 9483:LMNB1
uniprot id: F7EH81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9483:RALYL
gene id: 9483:RALYL
uniprot id: A0A2R8MXM3
uniprot id: U3FCB5
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9483:TPR
gene id: 9483:TPR
uniprot id: F7IHS3
names: Similarity
messages: Belongs to the TPR family.

9483:PREB
gene id: 9483:PREB
uniprot id: U3EK40
uniprot id: U3FN18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9483:STEAP4
gene id: 9483:STEAP4
uniprot id: F7IQW3
uniprot id: U3CVX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9483:EMC3
gene id: 9483:EMC3
uniprot id: F7I2L0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9483:PCMT1
gene id: 9483:PCMT1
uniprot id: A0A2R8PE27
uniprot id: A0A8J8XFP4
uniprot id: F7BKY4
uniprot id: U3D486
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9483:ACKR3
gene id: 9483:ACKR3
uniprot id: F7HZX1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:IP6K1
gene id: 9483:IP6K1
uniprot id: U3EJP7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9483:NDUFB8
gene id: 9483:NDUFB8
uniprot id: F7HY80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9483:ZCCHC8
gene id: 9483:ZCCHC8
uniprot id: U3EU68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

9483:GPR68
gene id: 9483:GPR68
uniprot id: F7IGI0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:CMC2
gene id: 9483:CMC2
uniprot id: F6Z6C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9483:MUC13
gene id: 9483:MUC13
uniprot id: F7FAZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:NMD3
gene id: 9483:NMD3
uniprot id: F7BFU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9483:SLC5A7
gene id: 9483:SLC5A7
uniprot id: F6ZJ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9483:TRMT6
gene id: 9483:TRMT6
uniprot id: U3ES86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9483:TENT5C
gene id: 9483:TENT5C
uniprot id: F7IHS2
uniprot id: U3BX57
names: Similarity
messages: Belongs to the TENT family.

9483:GNAL
gene id: 9483:GNAL
uniprot id: F7I640
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

9483:AKAP8
gene id: 9483:AKAP8
uniprot id: F7DAJ9
names: Similarity
messages: Belongs to the AKAP95 family.

9483:LAGE3
gene id: 9483:LAGE3
uniprot id: F6XD09
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

9483:HAT1
gene id: 9483:HAT1
uniprot id: A0A8I4A0E4
uniprot id: F7E477
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

9483:ST3GAL2
gene id: 9483:ST3GAL2
uniprot id: F7G766
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:HUS1
gene id: 9483:HUS1
uniprot id: F7CW16
names: Similarity
messages: Belongs to the HUS1 family.

9483:HRH1
gene id: 9483:HRH1
uniprot id: F7DVD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100390575
gene id: 9483:LOC100390575
uniprot id: A0A2R8MCW0
names: Similarity
messages: Belongs to the PRR23 family.

9483:DNASE2B
gene id: 9483:DNASE2B
uniprot id: F6WHU9
names: Similarity
messages: Belongs to the DNase II family.

9483:TCF25
gene id: 9483:TCF25
uniprot id: F6R706
uniprot id: U3FVD4
names: Similarity
messages: Belongs to the TCF25 family.

9483:ACE2
gene id: 9483:ACE2
uniprot id: F7CNJ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9483:IDH3B
gene id: 9483:IDH3B
uniprot id: A0A2R8MF48
uniprot id: A0A2R8PB10
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9483:PRPF3
gene id: 9483:PRPF3
uniprot id: U3DW67
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9483:TMEFF1
gene id: 9483:TMEFF1
uniprot id: F6T7T3
names: Similarity
messages: Belongs to the MSANTD3 family.

9483:FAM227B
gene id: 9483:FAM227B
uniprot id: F7IDQ0
names: Similarity
messages: Belongs to the FAM227 family.

9483:GDF3
gene id: 9483:GDF3
uniprot id: F7F6I3
names: Similarity
messages: Belongs to the TGF-beta family.

9483:RAB3D
gene id: 9483:RAB3D
uniprot id: F7I8G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9483:GBE1
gene id: 9483:GBE1
uniprot id: F7GS69
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

9483:OPN3
gene id: 9483:OPN3
uniprot id: F7IH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:FAM160A2
gene id: 9483:FAM160A2
uniprot id: F7IQS6
uniprot id: U3C4A7
uniprot id: U3CPP9
names: Similarity
messages: Belongs to the FHIP family.

9483:WNT9B
gene id: 9483:WNT9B
uniprot id: F6W1Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:MRPL15
gene id: 9483:MRPL15
uniprot id: F6VPC6
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9483:SLC39A4
gene id: 9483:SLC39A4
uniprot id: A0A2R8MGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9483:TBCCD1
gene id: 9483:TBCCD1
uniprot id: A0A5F4WB63
uniprot id: U3BAK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

9483:DCP1B
gene id: 9483:DCP1B
uniprot id: U3FUU8
names: Similarity
messages: Belongs to the DCP1 family.

9483:TRIM33
gene id: 9483:TRIM33
uniprot id: F7I5Z0
uniprot id: F7I621
names: Subcellular Location Annotation
messages: Cytoplasm

9483:SLC35C2
gene id: 9483:SLC35C2
uniprot id: A0A8J8XE73
uniprot id: U3BE49
names: Subcellular Location Annotation
messages: Membrane

9483:PLAC8
gene id: 9483:PLAC8
uniprot id: A0A5F4WDZ0
names: Similarity
messages: Belongs to the cornifelin family.

9483:HMOX2
gene id: 9483:HMOX2
uniprot id: F7IJ83
names: Similarity
messages: Belongs to the heme oxygenase family.

9483:SDHD
gene id: 9483:SDHD
uniprot id: A0A2R8MKB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9483:RSL24D1
gene id: 9483:RSL24D1
uniprot id: A0A2R8MGE6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

9483:DPYSL5
gene id: 9483:DPYSL5
uniprot id: F7I2B9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9483:SMAD7
gene id: 9483:SMAD7
uniprot id: U3D430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9483:SLC24A2
gene id: 9483:SLC24A2
uniprot id: U3DDA8
uniprot id: U3E340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

9483:ABI2
gene id: 9483:ABI2
uniprot id: F7EFN7
uniprot id: F7F696
uniprot id: F7HCB1
uniprot id: F7HCB9
uniprot id: U3E8A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9483:WTAP
gene id: 9483:WTAP
uniprot id: U3BMJ8
uniprot id: U3E922
names: Similarity
messages: Belongs to the fl(2)d family.

9483:NT5C3A
gene id: 9483:NT5C3A
uniprot id: F7B495
uniprot id: F7GS71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9483:NAA60
gene id: 9483:NAA60
uniprot id: F7D7P8
uniprot id: F7HIN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane
messages: Nucleus

9483:NUDC
gene id: 9483:NUDC
uniprot id: F7F437
uniprot id: U3FM55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9483:LOC100414961
gene id: 9483:LOC100414961
uniprot id: A0A2R8MYK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:NAPB
gene id: 9483:NAPB
uniprot id: U3FUU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9483:MCPH1
gene id: 9483:MCPH1
uniprot id: A0A8I3W9V5
uniprot id: A0A8I3WU68
uniprot id: U3EH78
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

9483:FAM120A
gene id: 9483:FAM120A
uniprot id: U3BAQ1
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9483:CCNDBP1
gene id: 9483:CCNDBP1
uniprot id: F7I304
names: Similarity
names: Subunit
messages: Belongs to the CCNDBP1 family.
messages: Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3.

9483:SEC61A1
gene id: 9483:SEC61A1
uniprot id: F7F6Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:FGG
gene id: 9483:FGG
uniprot id: A0A5K1U0P4
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9483:LOC100407125
gene id: 9483:LOC100407125
uniprot id: F6U3I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

9483:PEMT
gene id: 9483:PEMT
uniprot id: U3F8M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9483:LOC100413069
gene id: 9483:LOC100413069
uniprot id: A0A8I3WQR7
names: Similarity
messages: Belongs to the SPAN-X family.

9483:LAPTM4A
gene id: 9483:LAPTM4A
uniprot id: U3EDB3
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9483:LOC108589652
gene id: 9483:LOC108589652
uniprot id: A0A5F4W5K8
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

9483:SCG2
gene id: 9483:SCG2
uniprot id: U3FS88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Interacts with Secretogranin III/SCG3.
messages: Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
messages: Secreted

9483:SGCZ
gene id: 9483:SGCZ
uniprot id: F7BV23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

9483:MAEL
gene id: 9483:MAEL
uniprot id: F7ICG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9483:LCMT1
gene id: 9483:LCMT1
uniprot id: U3B7Q5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9483:TICAM1
gene id: 9483:TICAM1
uniprot id: U3F0S9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.
messages: Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.
messages: Mitochondrion
messages: The N-terminal region is essential for activation of the IFNB promoter activity.
messages: autophagosome
messages: cytosol

9483:MINDY1
gene id: 9483:MINDY1
uniprot id: F7C0Z2
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

9483:AHR
gene id: 9483:AHR
uniprot id: F6X3Y4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:CTPS2
gene id: 9483:CTPS2
uniprot id: A0A5F4W4V1
uniprot id: A0A5F4W9T2
uniprot id: A0A5F4WL23
uniprot id: F7CKK2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9483:MRPL18
gene id: 9483:MRPL18
uniprot id: F6T3Q3
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

9483:TNFAIP6
gene id: 9483:TNFAIP6
uniprot id: F7IEL1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ZRANB2
gene id: 9483:ZRANB2
uniprot id: F7FZW4
uniprot id: F7GCD3
uniprot id: U3E0L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9483:CYP11B1
gene id: 9483:CYP11B1
uniprot id: A0A2R8MWH5
uniprot id: A0A8I3W6Q9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:NIPSNAP2
gene id: 9483:NIPSNAP2
uniprot id: A0A2R8MSI4
uniprot id: U3FEV3
names: Similarity
messages: Belongs to the NipSnap family.

9483:TMEM184A
gene id: 9483:TMEM184A
uniprot id: F7EB58
names: Subcellular Location Annotation
messages: Membrane

9483:ACKR4
gene id: 9483:ACKR4
uniprot id: F6VC38
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:MS4A2
gene id: 9483:MS4A2
uniprot id: F6RHF4
names: Similarity
messages: Belongs to the MS4A family.

9483:GPATCH11
gene id: 9483:GPATCH11
uniprot id: A0A8J8XKX4
names: Similarity
messages: Belongs to the GPATCH11 family.

9483:NKX2-8
gene id: 9483:NKX2-8
uniprot id: A0A2R8MHW5
names: Subcellular Location Annotation
messages: Nucleus

9483:POLR2B
gene id: 9483:POLR2B
uniprot id: F6PQF5
uniprot id: U3EIW2
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9483:DPYSL2
gene id: 9483:DPYSL2
uniprot id: U3F2W7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

9483:IL17B
gene id: 9483:IL17B
uniprot id: A0A2R8MI68
uniprot id: A0A5F4WDJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9483:CA11
gene id: 9483:CA11
uniprot id: F7GMD1
uniprot id: U3ARJ9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9483:DEFB108B
gene id: 9483:DEFB108B
uniprot id: F6RM81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:SLC13A5
gene id: 9483:SLC13A5
uniprot id: A0A8J8XV24
uniprot id: A0A8J8YKQ5
uniprot id: H9KX93
uniprot id: H9KX94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9483:PTS
gene id: 9483:PTS
uniprot id: F7I609
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9483:ADAM19
gene id: 9483:ADAM19
uniprot id: U3FXS6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SNX17
gene id: 9483:SNX17
uniprot id: F7IBA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9483:CENPL
gene id: 9483:CENPL
uniprot id: F7HWA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

9483:CFAP206
gene id: 9483:CFAP206
uniprot id: A0A8I3VYY0
uniprot id: A0A8I3WGX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme
messages: cilium basal body

9483:SIAH2
gene id: 9483:SIAH2
uniprot id: F7I4Z0
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9483:RFC4
gene id: 9483:RFC4
uniprot id: U3CKN0
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9483:FAM102B
gene id: 9483:FAM102B
uniprot id: F7CJW2
names: Similarity
messages: Belongs to the FAM102 family.

9483:PCID2
gene id: 9483:PCID2
uniprot id: F6QNT5
names: Similarity
messages: Belongs to the CSN12 family.

9483:SNRNP200
gene id: 9483:SNRNP200
uniprot id: F7IBV6
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9483:DYRK3
gene id: 9483:DYRK3
uniprot id: A0A5F4WMC5
uniprot id: F7IFK0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9483:COPS7B
gene id: 9483:COPS7B
uniprot id: F7AUQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9483:BAP1
gene id: 9483:BAP1
uniprot id: F7GM69
names: Similarity
messages: Belongs to the peptidase C12 family.

9483:TCTN3
gene id: 9483:TCTN3
uniprot id: F6RGL6
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

9483:UCK1
gene id: 9483:UCK1
uniprot id: U3BMZ3
names: Similarity
messages: Belongs to the uridine kinase family.

9483:TPMT
gene id: 9483:TPMT
uniprot id: F6PNF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

9483:DPH3
gene id: 9483:DPH3
uniprot id: F7GJH5
names: Similarity
messages: Belongs to the DPH3 family.

9483:LOC100398528
gene id: 9483:LOC100398528
uniprot id: U3E5L2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9483:ZFPL1
gene id: 9483:ZFPL1
uniprot id: F7C4Y3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9483:CPA1
gene id: 9483:CPA1
uniprot id: F6WX16
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:RANBP10
gene id: 9483:RANBP10
uniprot id: F6WWM1
uniprot id: U3DAX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RANBP9/10 family.
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:APOA4
gene id: 9483:APOA4
uniprot id: B0KWR0
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9483:SLBP
gene id: 9483:SLBP
uniprot id: U3DWT0
names: Similarity
messages: Belongs to the SLBP family.

9483:MFNG
gene id: 9483:MFNG
uniprot id: U3ECV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:CYGB
gene id: 9483:CYGB
uniprot id: U3CP12
names: Similarity
messages: Belongs to the globin family.

9483:RNF170
gene id: 9483:RNF170
uniprot id: U3CM22
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:RPL39L
gene id: 9483:RPL39L
uniprot id: A0A8I3W7A5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

9483:CPT1A
gene id: 9483:CPT1A
uniprot id: U3DBW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:REM2
gene id: 9483:REM2
uniprot id: U3D9H4
names: Subcellular Location Annotation
messages: Cell membrane

9483:PTPRCAP
gene id: 9483:PTPRCAP
uniprot id: F7CSZ1
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CD45/PTPRC.
messages: Membrane

9483:C1D
gene id: 9483:C1D
uniprot id: F7HJF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9483:OR51A4
gene id: 9483:OR51A4
uniprot id: B0VXA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:SEC62
gene id: 9483:SEC62
uniprot id: F7C318
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:MSI1
gene id: 9483:MSI1
uniprot id: F7GNN3
names: Similarity
messages: Belongs to the Musashi family.

9483:P2RY1
gene id: 9483:P2RY1
uniprot id: F6VY42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PARPBP
gene id: 9483:PARPBP
uniprot id: F7INL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9483:GUCA2A
gene id: 9483:GUCA2A
uniprot id: F7IC85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9483:UCP2
gene id: 9483:UCP2
uniprot id: F7IHA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:LYVE1
gene id: 9483:LYVE1
uniprot id: A0A5F4W3K1
uniprot id: F7H6X6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:RPS6KB1
gene id: 9483:RPS6KB1
uniprot id: F7GCV0
uniprot id: F7IIP5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9483:SAMD8
gene id: 9483:SAMD8
uniprot id: U3EKZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9483:OPA3
gene id: 9483:OPA3
uniprot id: F7IF97
uniprot id: F7IFA3
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9483:SNAPIN
gene id: 9483:SNAPIN
uniprot id: F6RYC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9483:COX11
gene id: 9483:COX11
uniprot id: U3DRV0
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9483:TAGLN3
gene id: 9483:TAGLN3
uniprot id: U3CP74
names: Similarity
messages: Belongs to the calponin family.

9483:AGTR2
gene id: 9483:AGTR2
uniprot id: F6Q2S1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9483:ALDOC
gene id: 9483:ALDOC
uniprot id: F7I8Q1
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9483:NKD1
gene id: 9483:NKD1
uniprot id: U3BTU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9483:ACTBL2
gene id: 9483:ACTBL2
uniprot id: A0A8I3WN26
names: Similarity
messages: Belongs to the actin family.

9483:OPALIN
gene id: 9483:OPALIN
uniprot id: F6WCK4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9483:LOC100397327
gene id: 9483:LOC100397327
uniprot id: F7DX97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TYROBP
gene id: 9483:TYROBP
uniprot id: U3CY64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

9483:LOC100896161
gene id: 9483:LOC100896161
uniprot id: F6VEW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:OST4
gene id: 9483:OST4
uniprot id: A0A2R8M6K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:TRIM68
gene id: 9483:TRIM68
uniprot id: F7A322
uniprot id: U3EE72
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:ELAPOR2
gene id: 9483:ELAPOR2
uniprot id: A0A8I3W3Z1
uniprot id: F7EQP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9483:CFLAR
gene id: 9483:CFLAR
uniprot id: F7IMN8
names: Similarity
messages: Belongs to the peptidase C14A family.

9483:BST1
gene id: 9483:BST1
uniprot id: F7IS41
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9483:HSD17B1
gene id: 9483:HSD17B1
uniprot id: Q9GME2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

9483:EIF4EBP3
gene id: 9483:EIF4EBP3
uniprot id: F7CJA3
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9483:MCHR2
gene id: 9483:MCHR2
uniprot id: F7I268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:RHCE
gene id: 9483:RHCE
uniprot id: F7I3R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9483:PGP
gene id: 9483:PGP
uniprot id: F7GP32
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9483:NOG
gene id: 9483:NOG
uniprot id: U3FU84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9483:TREM1
gene id: 9483:TREM1
uniprot id: A0A8I3WDM5
uniprot id: F6RIK3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:CHIT1
gene id: 9483:CHIT1
uniprot id: F7H9D8
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9483:OR2T2
gene id: 9483:OR2T2
uniprot id: F7GB81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:IRF3
gene id: 9483:IRF3
uniprot id: F7HB60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9483:COPG2
gene id: 9483:COPG2
uniprot id: U3CBT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9483:DCP1A
gene id: 9483:DCP1A
uniprot id: F6X3U6
uniprot id: U3D2Q4
names: Similarity
messages: Belongs to the DCP1 family.

9483:ESYT3
gene id: 9483:ESYT3
uniprot id: U3B9Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:CDC25A
gene id: 9483:CDC25A
uniprot id: F6UZN3
uniprot id: F6UZV6
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9483:FAM151A
gene id: 9483:FAM151A
uniprot id: F6UFE2
names: Similarity
messages: Belongs to the FAM151 family.

9483:STX12
gene id: 9483:STX12
uniprot id: U3EHM2
names: Similarity
messages: Belongs to the syntaxin family.

9483:PLXNB3
gene id: 9483:PLXNB3
uniprot id: U3C8V2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:C11H11orf54
gene id: 9483:C11H11orf54
uniprot id: A0A8I4A4N5
uniprot id: F6RKF2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9483:ABRAXAS1
gene id: 9483:ABRAXAS1
uniprot id: U3D986
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
messages: Nucleus

9483:ANKRD34B
gene id: 9483:ANKRD34B
uniprot id: F7GY10
names: Similarity
messages: Belongs to the ANKRD34 family.

9483:XPC
gene id: 9483:XPC
uniprot id: U3DIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

9483:RPL34
gene id: 9483:RPL34
uniprot id: F7HLG2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9483:TMED7
gene id: 9483:TMED7
uniprot id: U3EUI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9483:MTX2
gene id: 9483:MTX2
uniprot id: A0A5F4WBC3
uniprot id: U3ECU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:CAMK2N2
gene id: 9483:CAMK2N2
uniprot id: U3FKG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9483:PHTF2
gene id: 9483:PHTF2
uniprot id: F7I8N8
uniprot id: U3DLV2
names: Subcellular Location Annotation
messages: Membrane

9483:SRPX2
gene id: 9483:SRPX2
uniprot id: F7CN77
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

9483:EEF2
gene id: 9483:EEF2
uniprot id: A0SXL6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9. Interacts with RBPMS2.
messages: Cytoplasm
messages: Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine (By similarity).
messages: ISGylated.
messages: Nucleus
messages: Phosphorylation by EF-2 kinase completely inactivates EF-2; it requires prior phosphorylation by CDK2 at Ser-595 during mitotic prometaphase. Phosphorylation by CSK promotes SUMOylation, proteolytic cleavage, and nuclear translocation if the C-terminal fragment.
messages: Proteolytically processed at two sites following phosphorylation by CSK.
messages: SUMOylated following phosphorylation by CSK, promotes proteolytic cleavage.

9483:LOC100414558
gene id: 9483:LOC100414558
uniprot id: B0VXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:NAV3
gene id: 9483:NAV3
uniprot id: F7FLL5
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9483:MASP1
gene id: 9483:MASP1
uniprot id: F6R2R9
uniprot id: U3EHF2
uniprot id: U3FSL2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:CHRND
gene id: 9483:CHRND
uniprot id: F7D2F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:CYP1A1
gene id: 9483:CYP1A1
uniprot id: F7DIB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9483:DLD
gene id: 9483:DLD
uniprot id: F7I3R3
uniprot id: U3DXC0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9483:TEX261
gene id: 9483:TEX261
uniprot id: F7GTP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

9483:SVBP
gene id: 9483:SVBP
uniprot id: A0A8I3W3E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

9483:FOXN3
gene id: 9483:FOXN3
uniprot id: F7HBY1
uniprot id: F7HH72
uniprot id: U3AX94
names: Subcellular Location Annotation
messages: Nucleus

9483:TCTA
gene id: 9483:TCTA
uniprot id: A0A8I3X618
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

9483:LOC100396215
gene id: 9483:LOC100396215
uniprot id: F7IT65
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:NDEL1
gene id: 9483:NDEL1
uniprot id: A0A8I3WI93
uniprot id: F7HZV9
uniprot id: F7HZW8
uniprot id: U3AVW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9483:JPH4
gene id: 9483:JPH4
uniprot id: U3CU54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9483:GTF2H4
gene id: 9483:GTF2H4
uniprot id: A0A8J8XII6
uniprot id: U3C5X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9483:CDH6
gene id: 9483:CDH6
uniprot id: F7IMY6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:CCT3
gene id: 9483:CCT3
uniprot id: F7HMY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:CALCA
gene id: 9483:CALCA
uniprot id: U3EPP1
names: Similarity
messages: Belongs to the calcitonin family.

9483:CMTM8
gene id: 9483:CMTM8
uniprot id: U3F7P3
names: Subcellular Location Annotation
messages: Membrane

9483:PRDM8
gene id: 9483:PRDM8
uniprot id: F7DBV8
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100409364
gene id: 9483:LOC100409364
uniprot id: F7IF34
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the Flattop family.

9483:TOMM20
gene id: 9483:TOMM20
uniprot id: F6TRU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:NPPB
gene id: 9483:NPPB
uniprot id: F6TAL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9483:GPAT3
gene id: 9483:GPAT3
uniprot id: F7H1W7
uniprot id: U3D170
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9483:MARCKSL1
gene id: 9483:MARCKSL1
uniprot id: U3CP24
names: Similarity
messages: Belongs to the MARCKS family.

9483:CNR1
gene id: 9483:CNR1
uniprot id: F7CF55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Signaling typically involves reduction in cyclic AMP.
messages: Interacts (via C-terminus) with CNRIP1.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

9483:PTPN4
gene id: 9483:PTPN4
uniprot id: A0A5F4VQQ4
uniprot id: F7GY33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9483:PIH1D1
gene id: 9483:PIH1D1
uniprot id: F7EIZ3
uniprot id: U3CVS6
names: Similarity
messages: Belongs to the PIH1 family.

9483:PAX7
gene id: 9483:PAX7
uniprot id: F7I097
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9483:UMPS
gene id: 9483:UMPS
uniprot id: U3E3B4
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9483:SOSTDC1
gene id: 9483:SOSTDC1
uniprot id: F6USQ7
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC100398205
gene id: 9483:LOC100398205
uniprot id: A0A2R8MUI6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:TXLNB
gene id: 9483:TXLNB
uniprot id: U3DG24
names: Similarity
messages: Belongs to the taxilin family.

9483:STX1B
gene id: 9483:STX1B
uniprot id: U3F4G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

9483:ZNF622
gene id: 9483:ZNF622
uniprot id: F6XP45
uniprot id: U3FS90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9483:NPTX2
gene id: 9483:NPTX2
uniprot id: F6VRP3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:TMX2
gene id: 9483:TMX2
uniprot id: F7H9V7
uniprot id: U3E182
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9483:GPRIN3
gene id: 9483:GPRIN3
uniprot id: F7I4M4
uniprot id: U3FMS2
names: Function
messages: May be involved in neurite outgrowth.

9483:ARL4C
gene id: 9483:ARL4C
uniprot id: U3FEV8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9483:LIN54
gene id: 9483:LIN54
uniprot id: A0A5F4W2W1
uniprot id: F7GXH3
uniprot id: F7H2K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9483:PDZK1IP1
gene id: 9483:PDZK1IP1
uniprot id: F7DUI4
names: Subcellular Location Annotation
messages: Membrane

9483:SEMA3E
gene id: 9483:SEMA3E
uniprot id: F7F565
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:UBE2L3
gene id: 9483:UBE2L3
uniprot id: F7I7Z9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:RAD51D
gene id: 9483:RAD51D
uniprot id: A0A2R8MX66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9483:YWHAH
gene id: 9483:YWHAH
uniprot id: B0KWS1
names: Similarity
messages: Belongs to the 14-3-3 family.

9483:AP4E1
gene id: 9483:AP4E1
uniprot id: U3E0Y1
names: Function
names: Similarity
names: Subunit
messages: Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

9483:AK3
gene id: 9483:AK3
uniprot id: U3BDI8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9483:NSFL1C
gene id: 9483:NSFL1C
uniprot id: F7IQH8
uniprot id: U3CGN9
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

9483:NPC2
gene id: 9483:NPC2
uniprot id: F7HX33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9483:YIPF7
gene id: 9483:YIPF7
uniprot id: F7IMT4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:VPS4A
gene id: 9483:VPS4A
uniprot id: F7HIL2
uniprot id: U3DRT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9483:IPO9
gene id: 9483:IPO9
uniprot id: F6Y960
uniprot id: F6YAA9
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ORC5
gene id: 9483:ORC5
uniprot id: F7I1U2
names: Subcellular Location Annotation
messages: Nucleus

9483:XIRP1
gene id: 9483:XIRP1
uniprot id: F7FB75
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9483:CD5L
gene id: 9483:CD5L
uniprot id: A0A5F4W750
uniprot id: F7HDX2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ACTN1
gene id: 9483:ACTN1
uniprot id: U3CCV9
names: Similarity
messages: Belongs to the alpha-actinin family.

9483:AUH
gene id: 9483:AUH
uniprot id: F7ISC3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9483:PPP2CB
gene id: 9483:PPP2CB
uniprot id: F6XZ20
names: Similarity
messages: Belongs to the PPP phosphatase family.

9483:CD14
gene id: 9483:CD14
uniprot id: F7B9N7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft
messages: Secreted

9483:INTS12
gene id: 9483:INTS12
uniprot id: F7HYK2
uniprot id: F7HYK4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9483:NARF
gene id: 9483:NARF
uniprot id: F6SX42
names: Similarity
messages: Belongs to the NARF family.

9483:OPN1SW
gene id: 9483:OPN1SW
uniprot id: F7GQA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9483:TMEM106B
gene id: 9483:TMEM106B
uniprot id: F7BZZ4
uniprot id: U3EI86
names: Similarity
messages: Belongs to the TMEM106 family.

9483:TBK1
gene id: 9483:TBK1
uniprot id: A0A8I3WD22
uniprot id: U3D758
names: Subcellular Location Annotation
messages: Cytoplasm

9483:KIF5B
gene id: 9483:KIF5B
uniprot id: F6YJP5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:PTPRG
gene id: 9483:PTPRG
uniprot id: U3EX09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9483:P3H1
gene id: 9483:P3H1
uniprot id: F7IRA2
names: Similarity
messages: Belongs to the leprecan family.

9483:PIAS3
gene id: 9483:PIAS3
uniprot id: U3FA04
names: Similarity
messages: Belongs to the PIAS family.

9483:MPHOSPH8
gene id: 9483:MPHOSPH8
uniprot id: F7IFM1
names: Subcellular Location Annotation
messages: Nucleus

9483:NPRL2
gene id: 9483:NPRL2
uniprot id: F7EGD3
names: Similarity
messages: Belongs to the NPR2 family.

9483:MPP3
gene id: 9483:MPP3
uniprot id: F6SGV1
names: Similarity
messages: Belongs to the MAGUK family.

9483:UCN3
gene id: 9483:UCN3
uniprot id: H9KVL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9483:MDFI
gene id: 9483:MDFI
uniprot id: A0A8I3WUV7
names: Similarity
messages: Belongs to the MDFI family.

9483:LOC100394089
gene id: 9483:LOC100394089
uniprot id: F7BE03
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9483:STX7
gene id: 9483:STX7
uniprot id: B0KWA3
names: Similarity
messages: Belongs to the syntaxin family.

9483:SULT1C2
gene id: 9483:SULT1C2
uniprot id: U3B8E9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9483:SNX2
gene id: 9483:SNX2
uniprot id: F6S6F4
uniprot id: F7IH18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9483:DNASE1L3
gene id: 9483:DNASE1L3
uniprot id: A0A2R8M4Q4
names: Similarity
messages: Belongs to the DNase I family.

9483:CYP4Z1
gene id: 9483:CYP4Z1
uniprot id: F7DUM6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:MSRA
gene id: 9483:MSRA
uniprot id: U3E1A6
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

9483:CD44
gene id: 9483:CD44
uniprot id: F6PQY5
uniprot id: F7FML0
uniprot id: F7ICN5
uniprot id: U3DNN5
uniprot id: U3FDP6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

9483:SRSF1
gene id: 9483:SRSF1
uniprot id: U3DHN9
names: Similarity
messages: Belongs to the splicing factor SR family.

9483:CLDN7
gene id: 9483:CLDN7
uniprot id: F6UJ11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:CPA3
gene id: 9483:CPA3
uniprot id: F7HXH8
names: Similarity
messages: Belongs to the peptidase M14 family.

9483:RCAN1
gene id: 9483:RCAN1
uniprot id: F7ICJ9
uniprot id: F7ICK3
names: Similarity
messages: Belongs to the RCAN family.

9483:MRFAP1
gene id: 9483:MRFAP1
uniprot id: F6QM18
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

9483:BAK1
gene id: 9483:BAK1
uniprot id: F7ICC2
names: Similarity
messages: Belongs to the Bcl-2 family.

9483:SPOP
gene id: 9483:SPOP
uniprot id: F6X846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

9483:CENPH
gene id: 9483:CENPH
uniprot id: F7HY66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

9483:SLC25A15
gene id: 9483:SLC25A15
uniprot id: U3CT12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:FDPS
gene id: 9483:FDPS
uniprot id: F7GUQ3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9483:ATP6V0A1
gene id: 9483:ATP6V0A1
uniprot id: F6PPI0
uniprot id: U3CN61
uniprot id: U3DNG8
uniprot id: U3FPA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9483:YARS2
gene id: 9483:YARS2
uniprot id: F6T7V7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9483:SCARA5
gene id: 9483:SCARA5
uniprot id: F6UGK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
messages: Homotrimer.
messages: Membrane

9483:SLC25A11
gene id: 9483:SLC25A11
uniprot id: F6RKX7
uniprot id: F7EGM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:EMSY
gene id: 9483:EMSY
uniprot id: A0A2R8MG01
uniprot id: F6QX26
uniprot id: F7APR2
uniprot id: F7AQS1
uniprot id: F7H8N3
names: Subcellular Location Annotation
messages: Nucleus

9483:LHFPL6
gene id: 9483:LHFPL6
uniprot id: U3EXN1
names: Subcellular Location Annotation
messages: Membrane

9483:HRH4
gene id: 9483:HRH4
uniprot id: F7IT43
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:LOC108593825
gene id: 9483:LOC108593825
uniprot id: A0A8I3WKX0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:ZMPSTE24
gene id: 9483:ZMPSTE24
uniprot id: U3DGC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

9483:VAT1L
gene id: 9483:VAT1L
uniprot id: F7BEZ9
uniprot id: U3FTD7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9483:UBXN1
gene id: 9483:UBXN1
uniprot id: F7IK28
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ANO10
gene id: 9483:ANO10
uniprot id: A0A5F4VRG2
uniprot id: A0A5F4W8J9
uniprot id: A0A5F4WEL5
uniprot id: U3DKS8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SV2A
gene id: 9483:SV2A
uniprot id: F7C0F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9483:VIP
gene id: 9483:VIP
uniprot id: F7ID94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

9483:CDC6
gene id: 9483:CDC6
uniprot id: F6TLV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

9483:CSRNP2
gene id: 9483:CSRNP2
uniprot id: F7EDZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9483:NFYA
gene id: 9483:NFYA
uniprot id: F6PHK9
uniprot id: U3EB25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9483:CNFN
gene id: 9483:CNFN
uniprot id: F7FLV5
names: Similarity
messages: Belongs to the cornifelin family.

9483:DYNC1I2
gene id: 9483:DYNC1I2
uniprot id: F6X617
uniprot id: F6XTS7
uniprot id: F6YXR6
uniprot id: U3E2W1
uniprot id: U3EU34
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9483:CCDC126
gene id: 9483:CCDC126
uniprot id: F7HKB9
names: Subcellular Location Annotation
messages: Secreted

9483:LCLAT1
gene id: 9483:LCLAT1
uniprot id: A0A2R8MKZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:LOC108592192
gene id: 9483:LOC108592192
uniprot id: F7H244
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

9483:ATXN2
gene id: 9483:ATXN2
uniprot id: F6SS84
names: Similarity
messages: Belongs to the ataxin-2 family.

9483:CHMP1A
gene id: 9483:CHMP1A
uniprot id: A0A8I3XAU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9483:IL7R
gene id: 9483:IL7R
uniprot id: A5HJM1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R (By similarity).
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.

9483:USP13
gene id: 9483:USP13
uniprot id: U3CGS7
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:PRRC1
gene id: 9483:PRRC1
uniprot id: F7GSG9
uniprot id: U3EXL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

9483:PCBD2
gene id: 9483:PCBD2
uniprot id: F7HYZ8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

9483:COPS8
gene id: 9483:COPS8
uniprot id: F6TJS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

9483:SLC1A3
gene id: 9483:SLC1A3
uniprot id: A0A2R8PDV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9483:ATP5IF1
gene id: 9483:ATP5IF1
uniprot id: F7IA10
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9483:MAP2
gene id: 9483:MAP2
uniprot id: U3CWC0
uniprot id: U3DJZ7
uniprot id: U3EPV3
names: Subcellular Location Annotation
messages: cytoskeleton

9483:ATP8B4
gene id: 9483:ATP8B4
uniprot id: F7INA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9483:MALSU1
gene id: 9483:MALSU1
uniprot id: F7I240
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9483:LCAT
gene id: 9483:LCAT
uniprot id: A0A8I3WUV1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:SMPD1
gene id: 9483:SMPD1
uniprot id: F7IQZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

9483:VDAC3
gene id: 9483:VDAC3
uniprot id: A0A5K1UMK4
uniprot id: F7GY08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

9483:APTX
gene id: 9483:APTX
uniprot id: A0A8I3WXG5
uniprot id: F7IIK3
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

9483:PPP6C
gene id: 9483:PPP6C
uniprot id: U3EMC8
names: Similarity
messages: Belongs to the PPP phosphatase family.

9483:SLC19A2
gene id: 9483:SLC19A2
uniprot id: F7HG40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9483:PAPSS2
gene id: 9483:PAPSS2
uniprot id: F7F717
uniprot id: F7F7V0
uniprot id: F7FL78
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9483:MGAT4B
gene id: 9483:MGAT4B
uniprot id: U3CTV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:PITX2
gene id: 9483:PITX2
uniprot id: F6Q5G1
uniprot id: F7GV60
uniprot id: U3BJP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9483:SLC7A8
gene id: 9483:SLC7A8
uniprot id: A0A8I3W8P1
uniprot id: F7AI32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9483:RAMP1
gene id: 9483:RAMP1
uniprot id: F6PYH1
names: Similarity
messages: Belongs to the RAMP family.

9483:UTP25
gene id: 9483:UTP25
uniprot id: U3EH16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9483:HDAC1
gene id: 9483:HDAC1
uniprot id: F7CCQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.
messages: Nucleus

9483:TNRC6C
gene id: 9483:TNRC6C
uniprot id: U3FAC6
names: Similarity
messages: Belongs to the GW182 family.

9483:HAUS1
gene id: 9483:HAUS1
uniprot id: U3FPB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9483:ENO2
gene id: 9483:ENO2
uniprot id: F6QLJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9483:RPS27L
gene id: 9483:RPS27L
uniprot id: F7HWT8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9483:OSBPL3
gene id: 9483:OSBPL3
uniprot id: F6UM61
uniprot id: F6UUK5
uniprot id: F7E0F4
names: Similarity
messages: Belongs to the OSBP family.

9483:SFMBT1
gene id: 9483:SFMBT1
uniprot id: F7BZT4
names: Subcellular Location Annotation
messages: Nucleus

9483:KCNE5
gene id: 9483:KCNE5
uniprot id: F7GUE7
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9483:NOP10
gene id: 9483:NOP10
uniprot id: F7GPI1
names: Similarity
messages: Belongs to the NOP10 family.

9483:ALKBH6
gene id: 9483:ALKBH6
uniprot id: U3FY57
names: Similarity
messages: Belongs to the alkB family.

9483:FOXO3
gene id: 9483:FOXO3
uniprot id: F7IHR2
names: Subcellular Location Annotation
messages: Nucleus

9483:NMT1
gene id: 9483:NMT1
uniprot id: U3FB93
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9483:C14H2orf68
gene id: 9483:C14H2orf68
uniprot id: F7DPH6
names: Similarity
messages: Belongs to the UPF0561 family.

9483:FIP1L1
gene id: 9483:FIP1L1
uniprot id: F6XL63
uniprot id: F7HU37
uniprot id: F7HU47
uniprot id: U3CCA9
uniprot id: U3D9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9483:MCM7
gene id: 9483:MCM7
uniprot id: F7ALH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9483:FMO5
gene id: 9483:FMO5
uniprot id: A0A221I0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9483:ATG4D
gene id: 9483:ATG4D
uniprot id: F7D851
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9483:DRD3
gene id: 9483:DRD3
uniprot id: F7I391
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9483:MPP5
gene id: 9483:MPP5
uniprot id: A0A8J8XEW3
uniprot id: F6UGM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: tight junction

9483:COQ8A
gene id: 9483:COQ8A
uniprot id: F7GNJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

9483:EPHA4
gene id: 9483:EPHA4
uniprot id: F6WF88
uniprot id: U3EIW0
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Membrane

9483:KDM1A
gene id: 9483:KDM1A
uniprot id: F7HZ54
uniprot id: U3BZN3
uniprot id: U3DBY8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

9483:RANBP6
gene id: 9483:RANBP6
uniprot id: A0A8I3WLU3
uniprot id: F6Q4X4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:PPM1K
gene id: 9483:PPM1K
uniprot id: A0A8I3XBQ6
uniprot id: F7HI43
names: Similarity
messages: Belongs to the PP2C family.

9483:MRPL3
gene id: 9483:MRPL3
uniprot id: A0A2R8PK74
uniprot id: F7IC72
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9483:GRIN2A
gene id: 9483:GRIN2A
uniprot id: U3D564
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9483:CRK
gene id: 9483:CRK
uniprot id: F7DT53
names: Similarity
messages: Belongs to the CRK family.

9483:PMEL
gene id: 9483:PMEL
uniprot id: U3FEV6
names: Similarity
messages: Belongs to the PMEL/NMB family.

9483:PGF
gene id: 9483:PGF
uniprot id: F7ITA1
uniprot id: U3BDP8
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9483:ELOVL6
gene id: 9483:ELOVL6
uniprot id: A0A2R8MBN8
uniprot id: A0A2R8MSQ8
uniprot id: F6PTF0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9483:OAS2
gene id: 9483:OAS2
uniprot id: F7IQC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9483:USB1
gene id: 9483:USB1
uniprot id: F6TF64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

9483:SAMD4B
gene id: 9483:SAMD4B
uniprot id: U3E243
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9483:TRIM9
gene id: 9483:TRIM9
uniprot id: U3E5U9
uniprot id: U3EGA5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Nucleus
messages: cytoskeleton

9483:OSBPL11
gene id: 9483:OSBPL11
uniprot id: F6U8U2
names: Similarity
messages: Belongs to the OSBP family.

9483:SNRPD1
gene id: 9483:SNRPD1
uniprot id: F7I755
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP core protein family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
messages: cytosol

9483:SDF4
gene id: 9483:SDF4
uniprot id: U3BWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

9483:SERPINA11
gene id: 9483:SERPINA11
uniprot id: F7I7B1
names: Similarity
messages: Belongs to the serpin family.

9483:LOC100393733
gene id: 9483:LOC100393733
uniprot id: A0A5F4VY33
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9483:FCER1G
gene id: 9483:FCER1G
uniprot id: F7I6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9483:MARK2
gene id: 9483:MARK2
uniprot id: U3BAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9483:ITPK1
gene id: 9483:ITPK1
uniprot id: U3E1V5
names: Similarity
messages: Belongs to the ITPK1 family.

9483:GNPAT
gene id: 9483:GNPAT
uniprot id: U3DFZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9483:C11H11orf58
gene id: 9483:C11H11orf58
uniprot id: F7HVS5
names: Similarity
messages: Belongs to the SMAP family.

9483:NAT10
gene id: 9483:NAT10
uniprot id: U3BS85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

9483:TAF5
gene id: 9483:TAF5
uniprot id: F6SS06
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9483:CLCF1
gene id: 9483:CLCF1
uniprot id: A0A2R8MWL2
uniprot id: F6VY17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9483:ILDR1
gene id: 9483:ILDR1
uniprot id: F7GPP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9483:SMIM19
gene id: 9483:SMIM19
uniprot id: F7FD34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9483:CAP1
gene id: 9483:CAP1
uniprot id: F7I0Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers.
messages: Membrane

9483:LOC100412476
gene id: 9483:LOC100412476
uniprot id: O77570
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9483:GFUS
gene id: 9483:GFUS
uniprot id: U3C1T5
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9483:WASF2
gene id: 9483:WASF2
uniprot id: F7BLL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9483:FGF9
gene id: 9483:FGF9
uniprot id: F7I3P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
messages: Secreted

9483:UNC5A
gene id: 9483:UNC5A
uniprot id: F6ZXV4
uniprot id: U3FSB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9483:SLC52A3
gene id: 9483:SLC52A3
uniprot id: F7I496
uniprot id: U3C2T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9483:SETD6
gene id: 9483:SETD6
uniprot id: F6RN58
uniprot id: U3F1L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

9483:C1S
gene id: 9483:C1S
uniprot id: U3BUP2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:XCL1
gene id: 9483:XCL1
uniprot id: A0A8I3WZJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

9483:PDPK1
gene id: 9483:PDPK1
uniprot id: F7HA88
uniprot id: U3FJT0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

9483:SLC5A8
gene id: 9483:SLC5A8
uniprot id: A0A5F4WFU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9483:FAM20A
gene id: 9483:FAM20A
uniprot id: F6SZH8
names: Similarity
messages: Belongs to the FAM20 family.

9483:TDP1
gene id: 9483:TDP1
uniprot id: U3DHI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9483:PPARGC1B
gene id: 9483:PPARGC1B
uniprot id: F7ICR5
uniprot id: U3BVQ2
names: Subcellular Location Annotation
messages: Nucleus

9483:SSR4
gene id: 9483:SSR4
uniprot id: F7FX02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9483:PPP4R3C
gene id: 9483:PPP4R3C
uniprot id: F7BFK1
names: Similarity
messages: Belongs to the SMEK family.

9483:CD40LG
gene id: 9483:CD40LG
uniprot id: Q9BDN3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9483:OCEL1
gene id: 9483:OCEL1
uniprot id: F7IEP3
names: Similarity
messages: Belongs to the ELL/occludin family.

9483:TRAF5
gene id: 9483:TRAF5
uniprot id: U3DJM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9483:PCYOX1
gene id: 9483:PCYOX1
uniprot id: U3EDH1
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9483:POU5F1
gene id: 9483:POU5F1
uniprot id: F6U7N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Nucleus

9483:AARSD1
gene id: 9483:AARSD1
uniprot id: U3FLJ6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9483:LOC100401239
gene id: 9483:LOC100401239
uniprot id: A0A2R8MVQ0
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

9483:MRRF
gene id: 9483:MRRF
uniprot id: A0A2R8M7C8
uniprot id: F6YGI3
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9483:MON1A
gene id: 9483:MON1A
uniprot id: F7HTY3
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9483:DNAJC10
gene id: 9483:DNAJC10
uniprot id: A0A5F4VYX5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.
messages: Endoplasmic reticulum lumen

9483:PLOD3
gene id: 9483:PLOD3
uniprot id: U3CXC2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9483:CHRNB3
gene id: 9483:CHRNB3
uniprot id: F7IIU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:GNG12
gene id: 9483:GNG12
uniprot id: F7E106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:TSEN54
gene id: 9483:TSEN54
uniprot id: F7INL6
names: Similarity
messages: Belongs to the SEN54 family.

9483:AKR1B10
gene id: 9483:AKR1B10
uniprot id: F7IMQ0
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9483:MMRN1
gene id: 9483:MMRN1
uniprot id: F7GB72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ERN2
gene id: 9483:ERN2
uniprot id: F7I6Y8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:MEF2D
gene id: 9483:MEF2D
uniprot id: U3D4G6
names: Subcellular Location Annotation
messages: Nucleus

9483:MRPS5
gene id: 9483:MRPS5
uniprot id: A0A5F4W268
uniprot id: F7HP99
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9483:OTUB1
gene id: 9483:OTUB1
uniprot id: F6QN11
names: Similarity
messages: Belongs to the peptidase C65 family.

9483:STON2
gene id: 9483:STON2
uniprot id: A0A2R8N120
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

9483:DMRTA2
gene id: 9483:DMRTA2
uniprot id: A0A2R8MD45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9483:TMEM177
gene id: 9483:TMEM177
uniprot id: F7I6M8
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

9483:BVES
gene id: 9483:BVES
uniprot id: F7GPZ8
names: Similarity
messages: Belongs to the popeye family.

9483:CARMIL1
gene id: 9483:CARMIL1
uniprot id: U3DPX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9483:NAAA
gene id: 9483:NAAA
uniprot id: A0A8I3W3F5
uniprot id: A0A8I3WJW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9483:DTYMK
gene id: 9483:DTYMK
uniprot id: F7ED91
names: Similarity
messages: Belongs to the thymidylate kinase family.

9483:IL13
gene id: 9483:IL13
uniprot id: B0KWP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-4/IL-13 family.
messages: Interacts with IL13RA2.
messages: Secreted

9483:DHH
gene id: 9483:DHH
uniprot id: F7I6S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9483:PNP
gene id: 9483:PNP
uniprot id: F7IC61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

9483:EFNA4
gene id: 9483:EFNA4
uniprot id: F7A539
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:MOGAT3
gene id: 9483:MOGAT3
uniprot id: A0A5F4VZH5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ELOVL1
gene id: 9483:ELOVL1
uniprot id: U3D550
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9483:SCMH1
gene id: 9483:SCMH1
uniprot id: F7IH32
uniprot id: F7IJE0
uniprot id: F7IJE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9483:SMIM7
gene id: 9483:SMIM7
uniprot id: U3DUY0
names: Similarity
messages: Belongs to the SMIM7 family.

9483:RDH10
gene id: 9483:RDH10
uniprot id: U3DMT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9483:DGAT1
gene id: 9483:DGAT1
uniprot id: A0A5F4W2M8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

9483:MID1IP1
gene id: 9483:MID1IP1
uniprot id: F7IE07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9483:HPGD
gene id: 9483:HPGD
uniprot id: U3D0A5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:XK
gene id: 9483:XK
uniprot id: U3CQG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9483:HOXB8
gene id: 9483:HOXB8
uniprot id: A0A2R8N4V1
names: Subcellular Location Annotation
messages: Nucleus

9483:TMEM183A
gene id: 9483:TMEM183A
uniprot id: F7H7W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

9483:SYNE4
gene id: 9483:SYNE4
uniprot id: U3D8U8
names: Similarity
messages: Belongs to the nesprin family.

9483:MPI
gene id: 9483:MPI
uniprot id: U3CWX3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9483:IFITM5
gene id: 9483:IFITM5
uniprot id: A0A2R8MEJ4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9483:CWC25
gene id: 9483:CWC25
uniprot id: U3EAP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9483:CRYZ
gene id: 9483:CRYZ
uniprot id: F7GNH5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9483:ZNF706
gene id: 9483:ZNF706
uniprot id: F7HSE6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:AWAT2
gene id: 9483:AWAT2
uniprot id: F7I5X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

9483:VANGL1
gene id: 9483:VANGL1
uniprot id: U3D5G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9483:PRKAB2
gene id: 9483:PRKAB2
uniprot id: F6YM87
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9483:LOC100403687
gene id: 9483:LOC100403687
uniprot id: A0A5F4VRR3
uniprot id: A0A8I3VZC5
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

9483:TLR7
gene id: 9483:TLR7
uniprot id: F6S8L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9483:MAT2A
gene id: 9483:MAT2A
uniprot id: F7F996
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9483:ZGPAT
gene id: 9483:ZGPAT
uniprot id: F7B996
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CHD4/Mi-2; the interaction is direct.
messages: Nucleus

9483:GSDMD
gene id: 9483:GSDMD
uniprot id: F7FCS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9483:CHMP7
gene id: 9483:CHMP7
uniprot id: U3DPV1
names: Similarity
messages: Belongs to the SNF7 family.

9483:LOC100388165
gene id: 9483:LOC100388165
uniprot id: F7I4U5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:DDR1
gene id: 9483:DDR1
uniprot id: U3CY78
names: Subcellular Location Annotation
messages: Membrane

9483:TMED6
gene id: 9483:TMED6
uniprot id: F6V4J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:EHD1
gene id: 9483:EHD1
uniprot id: B0KWK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9483:E2F4
gene id: 9483:E2F4
uniprot id: F7BSL2
uniprot id: U3DRH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9483:TMEM150C
gene id: 9483:TMEM150C
uniprot id: F7BRN5
names: Subcellular Location Annotation
messages: Membrane

9483:DCTPP1
gene id: 9483:DCTPP1
uniprot id: U3E7J8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9483:TMEM59
gene id: 9483:TMEM59
uniprot id: F7I1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:RECQL5
gene id: 9483:RECQL5
uniprot id: U3FTT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9483:A2M
gene id: 9483:A2M
uniprot id: F7IFF0
uniprot id: U3DSE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

9483:UCP1
gene id: 9483:UCP1
uniprot id: F7HVY5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

9483:SLC25A28
gene id: 9483:SLC25A28
uniprot id: A0A2R8M6A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:BROX
gene id: 9483:BROX
uniprot id: U3F6X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BROX family.
messages: Membrane

9483:IFI6
gene id: 9483:IFI6
uniprot id: F7IKE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9483:CDH20
gene id: 9483:CDH20
uniprot id: F7GWC6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:CADM1
gene id: 9483:CADM1
uniprot id: A0A2R8PKZ8
uniprot id: U3EZB7
names: Similarity
messages: Belongs to the nectin family.

9483:RIBC1
gene id: 9483:RIBC1
uniprot id: U3FQB0
names: Similarity
messages: Belongs to the RIB43A family.

9483:NKX2-1
gene id: 9483:NKX2-1
uniprot id: A0A5F4WL59
uniprot id: F6R3N0
names: Subcellular Location Annotation
messages: Nucleus

9483:FAM241A
gene id: 9483:FAM241A
uniprot id: F7H5J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9483:SPTY2D1
gene id: 9483:SPTY2D1
uniprot id: F6RDJ0
names: Similarity
messages: Belongs to the SPT2 family.

9483:LUM
gene id: 9483:LUM
uniprot id: A0A2R8M9W4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

9483:LAMB1
gene id: 9483:LAMB1
uniprot id: U3E535
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9483:CHSY3
gene id: 9483:CHSY3
uniprot id: F7GS31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9483:AATF
gene id: 9483:AATF
uniprot id: F6V458
names: Similarity
messages: Belongs to the AATF family.

9483:GCNT3
gene id: 9483:GCNT3
uniprot id: F7FUY3
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9483:IFNG
gene id: 9483:IFNG
uniprot id: B9VS86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

9483:RASSF5
gene id: 9483:RASSF5
uniprot id: F7IMG6
names: Subcellular Location Annotation
messages: cytoskeleton

9483:GATA2
gene id: 9483:GATA2
uniprot id: F7HXJ7
names: Subcellular Location Annotation
messages: Nucleus

9483:SF3A2
gene id: 9483:SF3A2
uniprot id: U3E527
names: Similarity
messages: Belongs to the SF3A2 family.

9483:LOC100406098
gene id: 9483:LOC100406098
uniprot id: A0A7R8C3F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

9483:S100B
gene id: 9483:S100B
uniprot id: F7HBN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

9483:ESCO1
gene id: 9483:ESCO1
uniprot id: A0A8J8Y947
names: Subcellular Location Annotation
messages: Nucleus

9483:PML
gene id: 9483:PML
uniprot id: F6SXY7
uniprot id: F6TV43
names: Subcellular Location Annotation
messages: Cytoplasm

9483:XRN1
gene id: 9483:XRN1
uniprot id: F7GUR3
uniprot id: U3CD29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

9483:SNTB2
gene id: 9483:SNTB2
uniprot id: F6Z6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9483:WNT10A
gene id: 9483:WNT10A
uniprot id: F7GQE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:THOC6
gene id: 9483:THOC6
uniprot id: U3C1X1
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9483:METTL11B
gene id: 9483:METTL11B
uniprot id: F7FX50
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9483:RSPRY1
gene id: 9483:RSPRY1
uniprot id: F6YSF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:OGFRL1
gene id: 9483:OGFRL1
uniprot id: F7HBA9
uniprot id: U3EEX7
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

9483:MBOAT7
gene id: 9483:MBOAT7
uniprot id: F6XQJ1
uniprot id: U3BIR4
names: Subcellular Location Annotation
messages: Membrane

9483:TSG101
gene id: 9483:TSG101
uniprot id: F6ZIZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Endosome membrane
messages: Membrane

9483:LAMB4
gene id: 9483:LAMB4
uniprot id: F6ZPP3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9483:GPHN
gene id: 9483:GPHN
uniprot id: A0A8I3WEH8
uniprot id: A0A8I3WIT4
uniprot id: F6VLS8
uniprot id: U3CGY7
uniprot id: U3FKH4
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9483:KREMEN1
gene id: 9483:KREMEN1
uniprot id: U3DHG7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

9483:TSR3
gene id: 9483:TSR3
uniprot id: U3CC06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:ASF1A
gene id: 9483:ASF1A
uniprot id: F6QXV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9483:OR5D18
gene id: 9483:OR5D18
uniprot id: A0A2R8MSW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TFIP11
gene id: 9483:TFIP11
uniprot id: F6YQH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9483:SDHA
gene id: 9483:SDHA
uniprot id: U3FBY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9483:SERF1A
gene id: 9483:SERF1A
uniprot id: F6SEZ1
names: Similarity
messages: Belongs to the SERF family.

9483:SLA
gene id: 9483:SLA
uniprot id: A0A2R8M685
names: Subcellular Location Annotation
messages: Cytoplasm

9483:TAT
gene id: 9483:TAT
uniprot id: F7H4H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9483:ACSL1
gene id: 9483:ACSL1
uniprot id: F7C1E6
uniprot id: Q9GLP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9483:BLVRA
gene id: 9483:BLVRA
uniprot id: U3ER63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

9483:GMFG
gene id: 9483:GMFG
uniprot id: U3CCC7
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9483:NEK7
gene id: 9483:NEK7
uniprot id: U3FJS7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:RAPGEF2
gene id: 9483:RAPGEF2
uniprot id: A0A2R8PKE4
uniprot id: U3DM90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAPGEF2 family.
messages: Cell junction
messages: Endosome
messages: Late endosome
messages: perinuclear region

9483:HNRNPH2
gene id: 9483:HNRNPH2
uniprot id: U3EAJ2
names: Subcellular Location Annotation
messages: nucleoplasm

9483:SLC41A2
gene id: 9483:SLC41A2
uniprot id: U3CH12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9483:HSD17B7
gene id: 9483:HSD17B7
uniprot id: U3EMT5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9483:TNP2
gene id: 9483:TNP2
uniprot id: A0A2R8PMU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: nucleolus

9483:METTL15
gene id: 9483:METTL15
uniprot id: A0A2R8NCP2
uniprot id: A0A8I3WZN5
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9483:TTC26
gene id: 9483:TTC26
uniprot id: F7H924
names: Similarity
messages: Belongs to the IFT56 family.

9483:CHM
gene id: 9483:CHM
uniprot id: U3C1F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9483:ENTR1
gene id: 9483:ENTR1
uniprot id: F6YQU3
uniprot id: F7IM48
names: Similarity
messages: Belongs to the ENTR1 family.

9483:HSD17B11
gene id: 9483:HSD17B11
uniprot id: F7IDG3
uniprot id: U3DLT9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:TIMM23B
gene id: 9483:TIMM23B
uniprot id: A0A2R8PCX8
uniprot id: F7GXV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9483:AHCYL2
gene id: 9483:AHCYL2
uniprot id: U3FUH1
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9483:SPTBN1
gene id: 9483:SPTBN1
uniprot id: F7H0A9
uniprot id: F7HG06
uniprot id: U3CSG0
names: Similarity
messages: Belongs to the spectrin family.

9483:LOC100400142
gene id: 9483:LOC100400142
uniprot id: F7FN63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9483:TMEM121
gene id: 9483:TMEM121
uniprot id: U3BBP2
names: Similarity
messages: Belongs to the TMEM121 family.

9483:LOC100399796
gene id: 9483:LOC100399796
uniprot id: A0A2R8MMI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LOC100415684
gene id: 9483:LOC100415684
uniprot id: F6SJY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:SEM1
gene id: 9483:SEM1
uniprot id: F7C1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

9483:MYORG
gene id: 9483:MYORG
uniprot id: U3CW44
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9483:MAP2K1
gene id: 9483:MAP2K1
uniprot id: U3CZR8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:MAN2A2
gene id: 9483:MAN2A2
uniprot id: F7A987
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9483:P2RY2
gene id: 9483:P2RY2
uniprot id: F7IT87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:PACSIN2
gene id: 9483:PACSIN2
uniprot id: U3E630
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9483:ZNF24
gene id: 9483:ZNF24
uniprot id: F7HFP7
names: Subcellular Location Annotation
messages: Nucleus

9483:STAM
gene id: 9483:STAM
uniprot id: F7E7C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9483:KCNJ16
gene id: 9483:KCNJ16
uniprot id: F7IRC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9483:AFF3
gene id: 9483:AFF3
uniprot id: F7DY78
names: Similarity
messages: Belongs to the AF4 family.

9483:SOGA3
gene id: 9483:SOGA3
uniprot id: A0A2R8ND74
names: Similarity
messages: Belongs to the SOGA family.

9483:ADGRA3
gene id: 9483:ADGRA3
uniprot id: U3E886
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9483:GTF2F1
gene id: 9483:GTF2F1
uniprot id: F6YN46
uniprot id: U3CYN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

9483:SRXN1
gene id: 9483:SRXN1
uniprot id: F7I4C5
names: Similarity
messages: Belongs to the sulfiredoxin family.

9483:PRCP
gene id: 9483:PRCP
uniprot id: A0A8I3X9G7
uniprot id: F7FFS2
names: Similarity
messages: Belongs to the peptidase S28 family.

9483:CNOT9
gene id: 9483:CNOT9
uniprot id: U3DJB7
uniprot id: U3E3W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9483:TMEM70
gene id: 9483:TMEM70
uniprot id: F7C1U3
names: Similarity
messages: Belongs to the TMEM70 family.

9483:LOC100385683
gene id: 9483:LOC100385683
uniprot id: A0A2R8P0B6
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9483:PDIK1L
gene id: 9483:PDIK1L
uniprot id: F7I2V6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:SLC4A10
gene id: 9483:SLC4A10
uniprot id: F6WN19
uniprot id: F7II08
uniprot id: U3EVC8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:ZEB1
gene id: 9483:ZEB1
uniprot id: A0A8J8YDF4
uniprot id: F6TXI4
uniprot id: F7FN11
uniprot id: F7HX65
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9483:CDC45
gene id: 9483:CDC45
uniprot id: F7IIN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9483:SMARCA5
gene id: 9483:SMARCA5
uniprot id: F6TP83
uniprot id: U3FB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9483:GDF10
gene id: 9483:GDF10
uniprot id: F6UYX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9483:ATP6
gene id: 9483:ATP6
uniprot id: E1CJB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9483:AFM
gene id: 9483:AFM
uniprot id: A0A5F4VV46
names: Subcellular Location Annotation
messages: Secreted

9483:FPGS
gene id: 9483:FPGS
uniprot id: F6QU94
uniprot id: F7DKP5
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

9483:ATP1B1
gene id: 9483:ATP1B1
uniprot id: F6THS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
messages: sarcolemma

9483:DPPA2
gene id: 9483:DPPA2
uniprot id: F6YXD7
names: Subcellular Location Annotation
messages: Nucleus

9483:SLC35F6
gene id: 9483:SLC35F6
uniprot id: U3DSE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLC35F solute transporter family.
messages: Interacts with SLC25A5.
messages: May play a role as a nucleotide-sugar transporter.
messages: Membrane
messages: Mitochondrion

9483:DPF2
gene id: 9483:DPF2
uniprot id: U3EF40
names: Similarity
messages: Belongs to the requiem/DPF family.

9483:COX2
gene id: 9483:COX2
uniprot id: E1CJB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9483:LPAR1
gene id: 9483:LPAR1
uniprot id: F6YCY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

9483:ZSCAN2
gene id: 9483:ZSCAN2
uniprot id: A0A8I3WID1
uniprot id: U3FGU6
names: Subcellular Location Annotation
messages: Nucleus

9483:IDUA
gene id: 9483:IDUA
uniprot id: U3CT60
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

9483:SLC66A2
gene id: 9483:SLC66A2
uniprot id: U3DGM0
uniprot id: U3DRZ3
names: Subcellular Location Annotation
messages: Membrane

9483:CYP27B1
gene id: 9483:CYP27B1
uniprot id: F7HIZ6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:MRM2
gene id: 9483:MRM2
uniprot id: U3ERQ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

9483:USP22
gene id: 9483:USP22
uniprot id: U3DA34
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:CCR4
gene id: 9483:CCR4
uniprot id: F7F2B0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:ME1
gene id: 9483:ME1
uniprot id: F7H233
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9483:MIP
gene id: 9483:MIP
uniprot id: F7EEJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:MED17
gene id: 9483:MED17
uniprot id: U3DKL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9483:ANO4
gene id: 9483:ANO4
uniprot id: U3E3T8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:ZNF500
gene id: 9483:ZNF500
uniprot id: F6Q7P6
names: Subcellular Location Annotation
messages: Nucleus

9483:ETV5
gene id: 9483:ETV5
uniprot id: F7FFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:ARHGEF3
gene id: 9483:ARHGEF3
uniprot id: A0A5K1VRD5
uniprot id: F7FYU0
uniprot id: F7GL31
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9483:RET
gene id: 9483:RET
uniprot id: F7I536
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

9483:GLYATL3
gene id: 9483:GLYATL3
uniprot id: A0A8I4A4R1
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9483:LOC100398394
gene id: 9483:LOC100398394
uniprot id: F6Q3N9
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9483:SSH3
gene id: 9483:SSH3
uniprot id: F7CT12
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9483:PDX1
gene id: 9483:PDX1
uniprot id: A0A8I3X1E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9483:PTPN2
gene id: 9483:PTPN2
uniprot id: U3DFJ3
uniprot id: U3FTG6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9483:CAST
gene id: 9483:CAST
uniprot id: A0A5F4W7D5
uniprot id: F7GIP0
uniprot id: F7GLR8
uniprot id: F7GQ91
uniprot id: F7GQ96
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

9483:KCNJ5
gene id: 9483:KCNJ5
uniprot id: A0A5F4W0J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9483:MS4A6A
gene id: 9483:MS4A6A
uniprot id: U3EIZ3
names: Function
names: Similarity
messages: Belongs to the MS4A family.
messages: May be involved in signal transduction as a component of a multimeric receptor complex.

9483:RER1
gene id: 9483:RER1
uniprot id: U3DIV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

9483:PCCA
gene id: 9483:PCCA
uniprot id: U3F4Z0
uniprot id: U3FV52
names: Subcellular Location Annotation
messages: Mitochondrion matrix

9483:GDF2
gene id: 9483:GDF2
uniprot id: F6UYA9
names: Similarity
messages: Belongs to the TGF-beta family.

9483:CACFD1
gene id: 9483:CACFD1
uniprot id: F7H4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

9483:SLC34A2
gene id: 9483:SLC34A2
uniprot id: F7F9F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

9483:LTBP1
gene id: 9483:LTBP1
uniprot id: U3C3V5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:EMG1
gene id: 9483:EMG1
uniprot id: F6YHU5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9483:C9H12orf43
gene id: 9483:C9H12orf43
uniprot id: U3EC11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

9483:HACD4
gene id: 9483:HACD4
uniprot id: A0A8I3WTI7
uniprot id: F6WUZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:LRRC8C
gene id: 9483:LRRC8C
uniprot id: F7GH23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9483:TMEM161A
gene id: 9483:TMEM161A
uniprot id: U3FUY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9483:CDC42SE2
gene id: 9483:CDC42SE2
uniprot id: F7IIP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9483:LOC100400561
gene id: 9483:LOC100400561
uniprot id: F7I4G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:RFT1
gene id: 9483:RFT1
uniprot id: U3D1L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9483:STK4
gene id: 9483:STK4
uniprot id: U3C4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9483:LOC100386566
gene id: 9483:LOC100386566
uniprot id: A0A8I3W428
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ZNF394
gene id: 9483:ZNF394
uniprot id: U3BRZ8
names: Subcellular Location Annotation
messages: Nucleus

9483:DCAF10
gene id: 9483:DCAF10
uniprot id: F6PGQ0
names: Function
names: Similarity
messages: Belongs to the WD repeat DCAF10 family.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9483:LACC1
gene id: 9483:LACC1
uniprot id: U3CY61
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

9483:ALCAM
gene id: 9483:ALCAM
uniprot id: U3EBE0
uniprot id: U3ELX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

9483:LPAR6
gene id: 9483:LPAR6
uniprot id: U3BLR3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:COL4A5
gene id: 9483:COL4A5
uniprot id: F7I4X5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9483:U2AF2
gene id: 9483:U2AF2
uniprot id: U3DD43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

9483:GABRG2
gene id: 9483:GABRG2
uniprot id: F6WUL1
uniprot id: F6XG46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:CYBA
gene id: 9483:CYBA
uniprot id: A0A5F4WCD8
uniprot id: U3EKP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

9483:CACNA1D
gene id: 9483:CACNA1D
uniprot id: F6VC98
uniprot id: F7FC05
uniprot id: F7I2J8
uniprot id: F7I2L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9483:PPIB
gene id: 9483:PPIB
uniprot id: F7ISM3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:DDB2
gene id: 9483:DDB2
uniprot id: F6XWE0
uniprot id: F6XWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

9483:DEF8
gene id: 9483:DEF8
uniprot id: F6U1L1
uniprot id: U3FLN5
names: Similarity
messages: Belongs to the DEF8 family.

9483:DDX59
gene id: 9483:DDX59
uniprot id: U3EVA9
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

9483:CRYAB
gene id: 9483:CRYAB
uniprot id: A0A2R8P261
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

9483:CELF6
gene id: 9483:CELF6
uniprot id: F6ZUM6
uniprot id: F7ILA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9483:CSGALNACT2
gene id: 9483:CSGALNACT2
uniprot id: F7HKL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9483:FOXR2
gene id: 9483:FOXR2
uniprot id: A0A2R8M5S6
names: Subcellular Location Annotation
messages: Nucleus

9483:ZNF75D
gene id: 9483:ZNF75D
uniprot id: F7III9
names: Subcellular Location Annotation
messages: Nucleus

9483:CYB5R4
gene id: 9483:CYB5R4
uniprot id: F7HJT5
uniprot id: U3BKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

9483:CDC73
gene id: 9483:CDC73
uniprot id: F7DT12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

9483:MAPRE1
gene id: 9483:MAPRE1
uniprot id: F7A401
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

9483:SNX13
gene id: 9483:SNX13
uniprot id: F6Z6T9
uniprot id: U3FK03
names: Similarity
messages: Belongs to the sorting nexin family.

9483:CDK2AP1
gene id: 9483:CDK2AP1
uniprot id: A0A8I3W4M4
names: Similarity
messages: Belongs to the CDK2AP family.

9483:SCD5
gene id: 9483:SCD5
uniprot id: F7HMC4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9483:TRAPPC2L
gene id: 9483:TRAPPC2L
uniprot id: U3DGS2
uniprot id: U3FMB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9483:TPM2
gene id: 9483:TPM2
uniprot id: U3CKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9483:KPNA4
gene id: 9483:KPNA4
uniprot id: U3BW75
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9483:CNTF
gene id: 9483:CNTF
uniprot id: U3EDL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9483:JPT1
gene id: 9483:JPT1
uniprot id: U3B1Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9483:ABCD3
gene id: 9483:ABCD3
uniprot id: A0A5F4W933
uniprot id: U3FKC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.
messages: Peroxisome membrane

9483:FER
gene id: 9483:FER
uniprot id: A0A8I3WXR3
uniprot id: F7I7H7
uniprot id: U3C8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

9483:AGRP
gene id: 9483:AGRP
uniprot id: F7I534
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:ETV4
gene id: 9483:ETV4
uniprot id: F6TZY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:MAPKAP1
gene id: 9483:MAPKAP1
uniprot id: F6ZTK1
uniprot id: F7B3S1
uniprot id: U3DL33
names: Similarity
messages: Belongs to the SIN1 family.

9483:LETM1
gene id: 9483:LETM1
uniprot id: F7DVP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:ADAM22
gene id: 9483:ADAM22
uniprot id: A0A2R8MSI5
uniprot id: A0A8I3W746
uniprot id: A0A8J8XKU3
uniprot id: F7IQU2
uniprot id: F7IT50
uniprot id: U3DZK3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:NOL11
gene id: 9483:NOL11
uniprot id: F7GSB7
names: Subcellular Location Annotation
messages: nucleolus

9483:SLC25A33
gene id: 9483:SLC25A33
uniprot id: U3E5R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:SNX9
gene id: 9483:SNX9
uniprot id: U3EQV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9483:IRAK4
gene id: 9483:IRAK4
uniprot id: F6ZUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

9483:CKS1B
gene id: 9483:CKS1B
uniprot id: F7IM94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9483:LOC100408493
gene id: 9483:LOC100408493
uniprot id: F6WV13
names: Similarity
messages: Belongs to the LCE family.

9483:CRHBP
gene id: 9483:CRHBP
uniprot id: U3C1E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9483:SERPINB3
gene id: 9483:SERPINB3
uniprot id: B0CMA6
names: Similarity
messages: Belongs to the serpin family.

9483:FRZB
gene id: 9483:FRZB
uniprot id: A0A5F4WMX9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9483:PGM5
gene id: 9483:PGM5
uniprot id: U3DV78
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9483:UBAC2
gene id: 9483:UBAC2
uniprot id: F7FK29
names: Subcellular Location Annotation
messages: Membrane

9483:SLC27A2
gene id: 9483:SLC27A2
uniprot id: F7ISY6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9483:DGKA
gene id: 9483:DGKA
uniprot id: F6YSP6
uniprot id: U3FIG2
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9483:KIF20B
gene id: 9483:KIF20B
uniprot id: F6ZCR6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:FLI1
gene id: 9483:FLI1
uniprot id: U3BDK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:EPHA5
gene id: 9483:EPHA5
uniprot id: A0A5F4W3L2
uniprot id: F7ITC6
uniprot id: U3ENY5
uniprot id: U3EYB4
names: Subcellular Location Annotation
messages: Membrane

9483:TMEM218
gene id: 9483:TMEM218
uniprot id: F6X530
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9483:LOC100393949
gene id: 9483:LOC100393949
uniprot id: F7IT04
names: Similarity
messages: Belongs to the PRORSD1 family.

9483:SUPT20H
gene id: 9483:SUPT20H
uniprot id: F6XLY6
uniprot id: F7ATN0
names: Similarity
messages: Belongs to the SPT20 family.

9483:SETDB2
gene id: 9483:SETDB2
uniprot id: F6VPZ5
uniprot id: U3D7Z6
names: Subcellular Location Annotation
messages: Chromosome

9483:DLX3
gene id: 9483:DLX3
uniprot id: F6REF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9483:DIS3
gene id: 9483:DIS3
uniprot id: F7CVL7
uniprot id: U3D226
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9483:ARAP3
gene id: 9483:ARAP3
uniprot id: U3CHS4
names: Subcellular Location Annotation
messages: Cytoplasm

9483:RFC2
gene id: 9483:RFC2
uniprot id: U3DF30
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9483:ME3
gene id: 9483:ME3
uniprot id: A0A2R8MMW3
uniprot id: A0A2R8MQ64
uniprot id: A0A5F4WAW0
uniprot id: A0A5F4WDJ1
uniprot id: F6W3U7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9483:FGFBP2
gene id: 9483:FGFBP2
uniprot id: A0A8I3VWG8
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9483:CTNNBIP1
gene id: 9483:CTNNBIP1
uniprot id: F6PXU5
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9483:NONO
gene id: 9483:NONO
uniprot id: U3F519
names: Subcellular Location Annotation
messages: Nucleus speckle

9483:SSR2
gene id: 9483:SSR2
uniprot id: U3FLN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9483:GPR87
gene id: 9483:GPR87
uniprot id: A0A2R8MD25
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:ELOF1
gene id: 9483:ELOF1
uniprot id: F7ABX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

9483:ATAT1
gene id: 9483:ATAT1
uniprot id: U3DBI3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

9483:NMU
gene id: 9483:NMU
uniprot id: Q5YLW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9483:EFNB3
gene id: 9483:EFNB3
uniprot id: U3E7W2
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC108593630
gene id: 9483:LOC108593630
uniprot id: A0A2R8MFI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9483:ADRA1D
gene id: 9483:ADRA1D
uniprot id: F7CTX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9483:IRF5
gene id: 9483:IRF5
uniprot id: F6RYK3
uniprot id: F6SJR4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:RSPO1
gene id: 9483:RSPO1
uniprot id: F7H9I5
names: Similarity
messages: Belongs to the R-spondin family.

9483:FBP1
gene id: 9483:FBP1
uniprot id: F7DT76
names: Similarity
messages: Belongs to the FBPase class 1 family.

9483:LMBR1
gene id: 9483:LMBR1
uniprot id: A0A2R8P8A6
uniprot id: F6WVI3
uniprot id: U3ECC1
names: Similarity
messages: Belongs to the LIMR family.

9483:RHBDD3
gene id: 9483:RHBDD3
uniprot id: F6VHH2
names: Subcellular Location Annotation
messages: Membrane

9483:HOMER2
gene id: 9483:HOMER2
uniprot id: F7IP78
uniprot id: U3D810
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9483:NDUFV2
gene id: 9483:NDUFV2
uniprot id: U3DYH6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

9483:RPL18A
gene id: 9483:RPL18A
uniprot id: A0A5F4WIS8
uniprot id: A0A5F4WM53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9483:PAFAH1B1
gene id: 9483:PAFAH1B1
uniprot id: F7HWL4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

9483:LOC100386370
gene id: 9483:LOC100386370
uniprot id: F7HAW6
names: Subcellular Location Annotation
messages: Membrane

9483:INSL5
gene id: 9483:INSL5
uniprot id: A0A8I4A3G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9483:PPP1R3B
gene id: 9483:PPP1R3B
uniprot id: F7FFM0
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9483:LIM2
gene id: 9483:LIM2
uniprot id: F7HZ88
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

9483:FOXJ2
gene id: 9483:FOXJ2
uniprot id: F7IKN2
uniprot id: U3FLZ1
names: Subcellular Location Annotation
messages: Nucleus

9483:CDC42EP2
gene id: 9483:CDC42EP2
uniprot id: F7I5F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9483:VCL
gene id: 9483:VCL
uniprot id: A0A5K1UWX2
uniprot id: U3B7Z2
uniprot id: U3FGU8
uniprot id: U3FL37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9483:NPPA
gene id: 9483:NPPA
uniprot id: F6TAQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

9483:GRP
gene id: 9483:GRP
uniprot id: F7DIJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
messages: Secreted
messages: neuron projection
messages: secretory vesicle lumen

9483:WNT6
gene id: 9483:WNT6
uniprot id: A0A5F4VXK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9483:LIPN
gene id: 9483:LIPN
uniprot id: F7HHB8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9483:TNFAIP1
gene id: 9483:TNFAIP1
uniprot id: F7I5U0
names: Similarity
messages: Belongs to the BACURD family.

9483:KPNB1
gene id: 9483:KPNB1
uniprot id: F7IN96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

9483:TMPRSS2
gene id: 9483:TMPRSS2
uniprot id: F7H6E7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:KIF5C
gene id: 9483:KIF5C
uniprot id: U3EUR0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:ARF5
gene id: 9483:ARF5
uniprot id: F7HBX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9483:FRAS1
gene id: 9483:FRAS1
uniprot id: F7DTY2
names: Similarity
messages: Belongs to the FRAS1 family.

9483:EIF4E2
gene id: 9483:EIF4E2
uniprot id: F6YZJ2
uniprot id: F6YZR4
uniprot id: F7F0B4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9483:GRWD1
gene id: 9483:GRWD1
uniprot id: F6S353
names: Subcellular Location Annotation
messages: Nucleus

9483:AP3B2
gene id: 9483:AP3B2
uniprot id: U3C4P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9483:RBCK1
gene id: 9483:RBCK1
uniprot id: A0A2R8N3F0
uniprot id: U3DDR1
names: Similarity
messages: Belongs to the RBR family.

9483:SDC4
gene id: 9483:SDC4
uniprot id: A4K2U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9483:SCAMP4
gene id: 9483:SCAMP4
uniprot id: U3DGC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9483:TOMM40
gene id: 9483:TOMM40
uniprot id: U3BA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:SERPINE1
gene id: 9483:SERPINE1
uniprot id: F7I5C2
names: Similarity
messages: Belongs to the serpin family.

9483:CFB
gene id: 9483:CFB
uniprot id: F7AP80
uniprot id: U3FAF5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:CUZD1
gene id: 9483:CUZD1
uniprot id: F6X244
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:PI4K2B
gene id: 9483:PI4K2B
uniprot id: F7HJ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9483:HINT1
gene id: 9483:HINT1
uniprot id: A0A2R8M646
names: Similarity
messages: Belongs to the HINT family.

9483:CREB1
gene id: 9483:CREB1
uniprot id: F7HRM8
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100400430
gene id: 9483:LOC100400430
uniprot id: A0A8I3ZYV9
uniprot id: F7I4V9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:LPAR5
gene id: 9483:LPAR5
uniprot id: F6XUY5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:BRINP2
gene id: 9483:BRINP2
uniprot id: F7E830
names: Similarity
messages: Belongs to the BRINP family.

9483:SLC5A6
gene id: 9483:SLC5A6
uniprot id: F7I0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9483:CCT6A
gene id: 9483:CCT6A
uniprot id: F7IN44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:KCNH4
gene id: 9483:KCNH4
uniprot id: U3D3F4
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9483:GPR161
gene id: 9483:GPR161
uniprot id: F6TLK2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:CEBPE
gene id: 9483:CEBPE
uniprot id: A0A2R8PMY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9483:COPB1
gene id: 9483:COPB1
uniprot id: F7GQX5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9483:CDK5RAP3
gene id: 9483:CDK5RAP3
uniprot id: F6UTR5
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9483:OSGEP
gene id: 9483:OSGEP
uniprot id: F7IEF6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

9483:OPRD1
gene id: 9483:OPRD1
uniprot id: F7IJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:IK
gene id: 9483:IK
uniprot id: U3F464
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9483:ST8SIA4
gene id: 9483:ST8SIA4
uniprot id: U3BGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:NPLOC4
gene id: 9483:NPLOC4
uniprot id: A0A8I3XDR6
uniprot id: F7IBF0
uniprot id: U3CGX0
names: Similarity
messages: Belongs to the NPL4 family.

9483:FAM171A1
gene id: 9483:FAM171A1
uniprot id: U3FNU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9483:CDIP1
gene id: 9483:CDIP1
uniprot id: U3E6P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9483:ARR3
gene id: 9483:ARR3
uniprot id: F7IME6
names: Function
names: Similarity
messages: Belongs to the arrestin family.
messages: May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.

9483:DUSP13
gene id: 9483:DUSP13
uniprot id: A0A5F4WAP2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9483:LOC100394084
gene id: 9483:LOC100394084
uniprot id: F7HN69
uniprot id: F7IAS0
uniprot id: U3BNA1
uniprot id: U3CEC7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9483:CEP57
gene id: 9483:CEP57
uniprot id: U3EI20
names: Similarity
messages: Belongs to the translokin family.

9483:BHMT
gene id: 9483:BHMT
uniprot id: A0A2R8MZT6
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9483:MAPK9
gene id: 9483:MAPK9
uniprot id: A0A2R8MHE7
uniprot id: U3CSF4
uniprot id: U3E7L6
uniprot id: U3EWQ9
uniprot id: U3F1Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9483:PLOD2
gene id: 9483:PLOD2
uniprot id: U3CUC8
uniprot id: U3E4Z2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9483:OSBPL1A
gene id: 9483:OSBPL1A
uniprot id: U3FP94
names: Similarity
messages: Belongs to the OSBP family.

9483:HIKESHI
gene id: 9483:HIKESHI
uniprot id: U3ED08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

9483:CBX8
gene id: 9483:CBX8
uniprot id: F7F3P9
names: Subcellular Location Annotation
messages: Nucleus

9483:PPIP5K2
gene id: 9483:PPIP5K2
uniprot id: A0A2R8ML71
uniprot id: F7CGN6
uniprot id: F7CH53
uniprot id: U3BTR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9483:PARP2
gene id: 9483:PARP2
uniprot id: F7FIN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9483:METTL4
gene id: 9483:METTL4
uniprot id: F7EZI7
uniprot id: U3F057
names: Similarity
messages: Belongs to the MT-A70-like family.

9483:UBE2D2
gene id: 9483:UBE2D2
uniprot id: A0A2R8PKA5
uniprot id: A0A8I3WWT6
uniprot id: U3DVQ8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:DMRT3
gene id: 9483:DMRT3
uniprot id: A0A5F4VV30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9483:MFF
gene id: 9483:MFF
uniprot id: A0A8I3WRP1
uniprot id: A0A8I3X5X3
uniprot id: F7BAA2
uniprot id: F7D518
uniprot id: F7E3K9
uniprot id: F7HI37
uniprot id: F7I7Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

9483:CHAF1A
gene id: 9483:CHAF1A
uniprot id: U3BQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHAF1A family.
messages: Nucleus

9483:CXCL2
gene id: 9483:CXCL2
uniprot id: A0A5F4VXZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:LOC100415316
gene id: 9483:LOC100415316
uniprot id: A0A2R8NFF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:NFASC
gene id: 9483:NFASC
uniprot id: A0A2R8M5W4
uniprot id: A0A2R8MV47
uniprot id: A0A2R8MVK0
uniprot id: F7I7W5
uniprot id: F7IAB0
uniprot id: F7ICJ5
uniprot id: F7ICM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

9483:ND1
gene id: 9483:ND1
uniprot id: E1CJA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:STARD13
gene id: 9483:STARD13
uniprot id: A0A8I3WG93
uniprot id: F6ZB18
uniprot id: U3D8C2
names: Subcellular Location Annotation
messages: Cytoplasm

9483:MPP2
gene id: 9483:MPP2
uniprot id: F6TFU1
uniprot id: F7I3R4
names: Similarity
messages: Belongs to the MAGUK family.

9483:ERI1
gene id: 9483:ERI1
uniprot id: U3B7N9
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ZNF592
gene id: 9483:ZNF592
uniprot id: U3AUS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9483:SPP1
gene id: 9483:SPP1
uniprot id: U3EES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

9483:GALT
gene id: 9483:GALT
uniprot id: F6VPS6
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9483:FASLG
gene id: 9483:FASLG
uniprot id: F7I0V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9483:LOC100411683
gene id: 9483:LOC100411683
uniprot id: B0VXB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TRAPPC4
gene id: 9483:TRAPPC4
uniprot id: U3C2I8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9483:LOC100408081
gene id: 9483:LOC100408081
uniprot id: A0A2R8MGA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:LHX5
gene id: 9483:LHX5
uniprot id: F7I4X9
names: Subcellular Location Annotation
messages: Nucleus

9483:ZNF215
gene id: 9483:ZNF215
uniprot id: F6YZN4
names: Subcellular Location Annotation
messages: Nucleus

9483:MAN1A2
gene id: 9483:MAN1A2
uniprot id: U3FXH5
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9483:ROS1
gene id: 9483:ROS1
uniprot id: F7CMX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9483:LOC103787206
gene id: 9483:LOC103787206
uniprot id: U3DJ48
names: Similarity
messages: Belongs to the pleiotrophin family.

9483:PYCR1
gene id: 9483:PYCR1
uniprot id: A0A8I3X6M6
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9483:RPL7L1
gene id: 9483:RPL7L1
uniprot id: F7IPT9
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9483:MRPS9
gene id: 9483:MRPS9
uniprot id: U3DD41
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9483:CYBASC3
gene id: 9483:CYBASC3
uniprot id: F7H7P9
uniprot id: F7H7Q3
names: Subcellular Location Annotation
messages: Membrane

9483:IL15
gene id: 9483:IL15
uniprot id: A0A2R8P5W0
uniprot id: F7ILX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9483:DYRK1A
gene id: 9483:DYRK1A
uniprot id: U3D765
uniprot id: U3E817
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9483:CDH8
gene id: 9483:CDH8
uniprot id: U3E3K3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:KCNK1
gene id: 9483:KCNK1
uniprot id: F6U0J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9483:CCL21
gene id: 9483:CCL21
uniprot id: F7B701
names: Subcellular Location Annotation
messages: Secreted

9483:LOC103792211
gene id: 9483:LOC103792211
uniprot id: A0A8I3W029
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:CYP27A1
gene id: 9483:CYP27A1
uniprot id: A0A7G0X095
uniprot id: F7CZ63
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:CDCA8
gene id: 9483:CDCA8
uniprot id: F7H9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9483:SERPING1
gene id: 9483:SERPING1
uniprot id: F7B8K7
names: Similarity
messages: Belongs to the serpin family.

9483:GLYATL2
gene id: 9483:GLYATL2
uniprot id: F7GHB0
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9483:GNS
gene id: 9483:GNS
uniprot id: F7ENH2
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9483:TMEM229B
gene id: 9483:TMEM229B
uniprot id: F6V5M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9483:LEO1
gene id: 9483:LEO1
uniprot id: F7CCM6
names: Similarity
messages: Belongs to the LEO1 family.

9483:PELI1
gene id: 9483:PELI1
uniprot id: F6QQB0
uniprot id: U3F2B6
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9483:SRC
gene id: 9483:SRC
uniprot id: A0A5F4W7Z4
uniprot id: F6W7M1
uniprot id: U3FMT0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:LNPEP
gene id: 9483:LNPEP
uniprot id: A0A8I3W2L7
uniprot id: F7HKT3
names: Similarity
messages: Belongs to the peptidase M1 family.

9483:NPM3
gene id: 9483:NPM3
uniprot id: F7GW19
names: Similarity
messages: Belongs to the nucleoplasmin family.

9483:CKS2
gene id: 9483:CKS2
uniprot id: F7HV56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9483:UHRF2
gene id: 9483:UHRF2
uniprot id: A0A8I3WGN2
uniprot id: A0A8I3WHD7
uniprot id: F6S9E2
names: Subcellular Location Annotation
messages: Nucleus

9483:RABGGTB
gene id: 9483:RABGGTB
uniprot id: F7H322
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9483:IL10
gene id: 9483:IL10
uniprot id: A0A7R8GUT3
uniprot id: Q0Z972
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-10 family.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Immune regulatory cytokine.
messages: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
messages: Secreted

9483:RFLNA
gene id: 9483:RFLNA
uniprot id: F7IAZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9483:CNOT6L
gene id: 9483:CNOT6L
uniprot id: A0A2R8M8X0
uniprot id: U3C2D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9483:NPNT
gene id: 9483:NPNT
uniprot id: F7IEY9
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CCS
gene id: 9483:CCS
uniprot id: D2KTC2
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

9483:ADH4
gene id: 9483:ADH4
uniprot id: A0A2R8MBZ6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.

9483:KCNT2
gene id: 9483:KCNT2
uniprot id: A0A5K1URB5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:VSNL1
gene id: 9483:VSNL1
uniprot id: F6YXV9
names: Function
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

9483:NUPR1
gene id: 9483:NUPR1
uniprot id: U3FHX8
names: Similarity
messages: Belongs to the NUPR family.

9483:SSBP2
gene id: 9483:SSBP2
uniprot id: A0A8I3W1R4
uniprot id: F7EWK9
uniprot id: F7FQL7
uniprot id: F7IE65
uniprot id: U3DVE1
uniprot id: U3EGN9
names: Subcellular Location Annotation
messages: Nucleus

9483:SBNO1
gene id: 9483:SBNO1
uniprot id: F6Y413
uniprot id: U3BXS3
names: Similarity
messages: Belongs to the SBNO family.

9483:FZD2
gene id: 9483:FZD2
uniprot id: A0A2R8MXI9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CPSF7
gene id: 9483:CPSF7
uniprot id: F7HI00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9483:LAMP5
gene id: 9483:LAMP5
uniprot id: F7DCD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9483:AKAP8L
gene id: 9483:AKAP8L
uniprot id: U3CVL9
names: Similarity
messages: Belongs to the AKAP95 family.

9483:CCDC85A
gene id: 9483:CCDC85A
uniprot id: A0A8I3W9K1
uniprot id: A0A8I3WLT9
uniprot id: F7I9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9483:CLSTN1
gene id: 9483:CLSTN1
uniprot id: U3FGM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9483:UNC13D
gene id: 9483:UNC13D
uniprot id: A0A8I4A115
names: Similarity
messages: Belongs to the unc-13 family.

9483:LVRN
gene id: 9483:LVRN
uniprot id: F6XCN7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9483:MAPK10
gene id: 9483:MAPK10
uniprot id: U3D021
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9483:NDOR1
gene id: 9483:NDOR1
uniprot id: F7GNC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.
messages: perinuclear region

9483:APEX2
gene id: 9483:APEX2
uniprot id: F6XGV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9483:FGF20
gene id: 9483:FGF20
uniprot id: A0A7U3JW33
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:NAA11
gene id: 9483:NAA11
uniprot id: F7DDU0
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9483:ZDHHC5
gene id: 9483:ZDHHC5
uniprot id: F6XIT1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:TRIM42
gene id: 9483:TRIM42
uniprot id: F7GYZ9
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ACTR1B
gene id: 9483:ACTR1B
uniprot id: U3FEU3
names: Similarity
messages: Belongs to the actin family.

9483:SRP9
gene id: 9483:SRP9
uniprot id: F7IIG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9483:SLC16A12
gene id: 9483:SLC16A12
uniprot id: A0A2R8MI35
names: Subcellular Location Annotation
messages: Membrane

9483:IL17A
gene id: 9483:IL17A
uniprot id: A5HJM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9483:DEFB126
gene id: 9483:DEFB126
uniprot id: A0A8I3WMU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:GPX8
gene id: 9483:GPX8
uniprot id: F7ISV1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9483:LOC100412562
gene id: 9483:LOC100412562
uniprot id: A0A7G0X101
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9483:SLC17A7
gene id: 9483:SLC17A7
uniprot id: F7EIW8
names: Subcellular Location Annotation
messages: Membrane

9483:MFSD6
gene id: 9483:MFSD6
uniprot id: F7IHY6
uniprot id: F7II00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9483:ANKLE2
gene id: 9483:ANKLE2
uniprot id: U3E802
names: Similarity
messages: Belongs to the ANKLE2 family.

9483:RASGRP3
gene id: 9483:RASGRP3
uniprot id: U3FQ81
names: Similarity
messages: Belongs to the RASGRP family.

9483:MITF
gene id: 9483:MITF
uniprot id: A0A5K1UW48
uniprot id: F6S413
uniprot id: F7FA74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9483:PARP1
gene id: 9483:PARP1
uniprot id: U3DZQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

9483:METTL2A
gene id: 9483:METTL2A
uniprot id: U3CWH5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9483:ERO1B
gene id: 9483:ERO1B
uniprot id: U3D8Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

9483:LOC100407817
gene id: 9483:LOC100407817
uniprot id: A0A2R8M412
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

9483:PES1
gene id: 9483:PES1
uniprot id: U3AUB5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

9483:RNFT2
gene id: 9483:RNFT2
uniprot id: A0A8I3WH16
names: Subcellular Location Annotation
messages: Membrane

9483:TXK
gene id: 9483:TXK
uniprot id: F7IBB6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9483:GLDN
gene id: 9483:GLDN
uniprot id: F7I4Y9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC100398645
gene id: 9483:LOC100398645
uniprot id: A0A8I3X648
names: Similarity
messages: Belongs to the actin family.

9483:CCR5
gene id: 9483:CCR5
uniprot id: Q9MZA0
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

9483:ARMCX3
gene id: 9483:ARMCX3
uniprot id: F7GD88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

9483:LOC108587691
gene id: 9483:LOC108587691
uniprot id: U3F605
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9483:SRF
gene id: 9483:SRF
uniprot id: F7HCP4
names: Subcellular Location Annotation
messages: Nucleus

9483:OXSM
gene id: 9483:OXSM
uniprot id: U3EWR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
messages: Mitochondrion

9483:MX1
gene id: 9483:MX1
uniprot id: U3EGN4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9483:NME4
gene id: 9483:NME4
uniprot id: F6S5S0
names: Similarity
messages: Belongs to the NDK family.

9483:SPCS2
gene id: 9483:SPCS2
uniprot id: F7IAN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:AGT
gene id: 9483:AGT
uniprot id: Q9TSZ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor.
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (By similarity).
messages: Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
messages: Secreted
messages: Stimulates aldosterone release.
messages: The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin (By similarity).

9483:RNPC3
gene id: 9483:RNPC3
uniprot id: F7CKT0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

9483:MRPL36
gene id: 9483:MRPL36
uniprot id: A0A2R8NA09
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

9483:TMEM33
gene id: 9483:TMEM33
uniprot id: F7F832
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9483:GAS8
gene id: 9483:GAS8
uniprot id: F6RWJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum axoneme

9483:LOC100410976
gene id: 9483:LOC100410976
uniprot id: B0VXB4
names: Similarity
messages: Belongs to the globin family.

9483:SMARCAL1
gene id: 9483:SMARCAL1
uniprot id: A0A5K1TUB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9483:LALBA
gene id: 9483:LALBA
uniprot id: F7I977
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

9483:ENY2
gene id: 9483:ENY2
uniprot id: U3FW45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9483:PDP1
gene id: 9483:PDP1
uniprot id: F7E6B2
names: Similarity
messages: Belongs to the PP2C family.

9483:PTPRE
gene id: 9483:PTPRE
uniprot id: F7HIJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

9483:CMKLR1
gene id: 9483:CMKLR1
uniprot id: F6Y569
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9483:MYO5C
gene id: 9483:MYO5C
uniprot id: U3BDP9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:MAP2K2
gene id: 9483:MAP2K2
uniprot id: U3F340
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:TAS2R1
gene id: 9483:TAS2R1
uniprot id: A0A1C9ZNM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9483:ZNF165
gene id: 9483:ZNF165
uniprot id: F7ID20
names: Subcellular Location Annotation
messages: Nucleus

9483:HSDL1
gene id: 9483:HSDL1
uniprot id: U3ARF3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:AKT3
gene id: 9483:AKT3
uniprot id: F7IF11
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9483:ERH
gene id: 9483:ERH
uniprot id: F7E9A4
uniprot id: F7ELJ3
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

9483:ILKAP
gene id: 9483:ILKAP
uniprot id: U3FLN4
names: Similarity
messages: Belongs to the PP2C family.

9483:PNPLA4
gene id: 9483:PNPLA4
uniprot id: A0A8I3X3T3
uniprot id: F7FNR1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SF3B4
gene id: 9483:SF3B4
uniprot id: F7GK55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9483:MAP3K9
gene id: 9483:MAP3K9
uniprot id: F7GPM0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9483:C22H19orf12
gene id: 9483:C22H19orf12
uniprot id: U3D0E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9483:CHMP1B
gene id: 9483:CHMP1B
uniprot id: U3FTU8
names: Similarity
messages: Belongs to the SNF7 family.

9483:LOC100412575
gene id: 9483:LOC100412575
uniprot id: U3AYH5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:HTRA1
gene id: 9483:HTRA1
uniprot id: U3F3W6
names: Similarity
messages: Belongs to the peptidase S1C family.

9483:FIS1
gene id: 9483:FIS1
uniprot id: F6UJN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

9483:GPR180
gene id: 9483:GPR180
uniprot id: A0A2R8P4S7
names: Subcellular Location Annotation
messages: Membrane

9483:MUL1
gene id: 9483:MUL1
uniprot id: U3F761
names: Subcellular Location Annotation
messages: Membrane

9483:LOC100399119
gene id: 9483:LOC100399119
uniprot id: A0A2R8MLV9
names: Subcellular Location Annotation
messages: Membrane

9483:ANAPC10
gene id: 9483:ANAPC10
uniprot id: F6YKH3
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

9483:SLC26A2
gene id: 9483:SLC26A2
uniprot id: F7H3N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

9483:CALR
gene id: 9483:CALR
uniprot id: F7I5Y4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen
messages: Monomer.

9483:RCAN2
gene id: 9483:RCAN2
uniprot id: U3DR93
uniprot id: U3F3B1
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9483:CXCR3
gene id: 9483:CXCR3
uniprot id: F7EVK5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

9483:SNCA
gene id: 9483:SNCA
uniprot id: F7GY62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

9483:STRIP1
gene id: 9483:STRIP1
uniprot id: F7FY24
names: Similarity
messages: Belongs to the STRIP family.

9483:GPR137C
gene id: 9483:GPR137C
uniprot id: F6UCN2
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9483:MIPEP
gene id: 9483:MIPEP
uniprot id: F7IG38
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9483:C1H9orf116
gene id: 9483:C1H9orf116
uniprot id: U3FKY6
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9483:ATP5F1E
gene id: 9483:ATP5F1E
uniprot id: F7GPK5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9483:ASB8
gene id: 9483:ASB8
uniprot id: A0A2R8MBP3
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9483:FN3KRP
gene id: 9483:FN3KRP
uniprot id: U3E2G4
names: Similarity
messages: Belongs to the fructosamine kinase family.

9483:CDH24
gene id: 9483:CDH24
uniprot id: F7DFL0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9483:LOC100406511
gene id: 9483:LOC100406511
uniprot id: A0A8I3WG68
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:IL1RL2
gene id: 9483:IL1RL2
uniprot id: F7DE27
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9483:LAP3
gene id: 9483:LAP3
uniprot id: F7IIB5
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9483:STRA6
gene id: 9483:STRA6
uniprot id: F7BJF2
uniprot id: F7GIN7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:TMEM98
gene id: 9483:TMEM98
uniprot id: F6ZJ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9483:DCP2
gene id: 9483:DCP2
uniprot id: A0A8J8Y249
uniprot id: F7B8L4
uniprot id: F7B8R3
uniprot id: U3C2I7
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9483:TRPC4
gene id: 9483:TRPC4
uniprot id: A0A5K1VJC0
names: Subcellular Location Annotation
messages: Membrane

9483:SMIM8
gene id: 9483:SMIM8
uniprot id: A0A8I3X399
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9483:CA4
gene id: 9483:CA4
uniprot id: U3DPM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

9483:PPP2R5D
gene id: 9483:PPP2R5D
uniprot id: A0A2R8MHR3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9483:ND4
gene id: 9483:ND4
uniprot id: A0A0U1XIU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

9483:IL1A
gene id: 9483:IL1A
uniprot id: F6VT34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

9483:NRG3
gene id: 9483:NRG3
uniprot id: A0A2R8MMV8
uniprot id: A0A2R8MX98
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MOV10
gene id: 9483:MOV10
uniprot id: F6UZ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9483:PIK3C3
gene id: 9483:PIK3C3
uniprot id: U3DFJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

9483:NDUFS2
gene id: 9483:NDUFS2
uniprot id: F7D5V5
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9483:SH3GLB1
gene id: 9483:SH3GLB1
uniprot id: F7AEZ1
uniprot id: F7BKI7
uniprot id: U3CI10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9483:TUBB6
gene id: 9483:TUBB6
uniprot id: F7BBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9483:TMEM131
gene id: 9483:TMEM131
uniprot id: A0A8I3X1T4
uniprot id: F6TUN3
names: Similarity
messages: Belongs to the TMEM131 family.

9483:INPP4A
gene id: 9483:INPP4A
uniprot id: A0A2R8M9Y8
uniprot id: F6W0Q3
uniprot id: U3D783
uniprot id: U3ET02
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9483:MYO1E
gene id: 9483:MYO1E
uniprot id: F7DDP5
uniprot id: U3BT73
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9483:CYB561
gene id: 9483:CYB561
uniprot id: A0A8I3X570
uniprot id: A0A8J8XKZ9
uniprot id: U3C0Q0
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

9483:CCNE2
gene id: 9483:CCNE2
uniprot id: F7HJQ8
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9483:ZDHHC12
gene id: 9483:ZDHHC12
uniprot id: U3C6Y4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:DLK2
gene id: 9483:DLK2
uniprot id: F7BVC0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SNX30
gene id: 9483:SNX30
uniprot id: U3F1I2
names: Similarity
messages: Belongs to the sorting nexin family.

9483:CAPRIN2
gene id: 9483:CAPRIN2
uniprot id: A0A2R8N4L1
uniprot id: F7I083
names: Similarity
messages: Belongs to the caprin family.

9483:MYLK
gene id: 9483:MYLK
uniprot id: F7HQU3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

9483:RGS5
gene id: 9483:RGS5
uniprot id: F6TDR7
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9483:CIAO1
gene id: 9483:CIAO1
uniprot id: F6WFZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9483:CANT1
gene id: 9483:CANT1
uniprot id: F7D6T0
names: Similarity
messages: Belongs to the apyrase family.

9483:NECAP1
gene id: 9483:NECAP1
uniprot id: U3CAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9483:IMMP1L
gene id: 9483:IMMP1L
uniprot id: F7I6I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9483:MME
gene id: 9483:MME
uniprot id: U3D5D7
names: Cofactor
messages: Binds 1 zinc ion per subunit.

9483:SOX21
gene id: 9483:SOX21
uniprot id: A0A2R8M5Q0
names: Subcellular Location Annotation
messages: Nucleus

9483:DMGDH
gene id: 9483:DMGDH
uniprot id: F6QJK1
names: Similarity
messages: Belongs to the GcvT family.

9483:FOXB1
gene id: 9483:FOXB1
uniprot id: F7DU19
names: Subcellular Location Annotation
messages: Nucleus

9483:USP14
gene id: 9483:USP14
uniprot id: U3DHC9
uniprot id: U3DSU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9483:SLC25A3
gene id: 9483:SLC25A3
uniprot id: F7AN83
uniprot id: U3EHX0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9483:SEC22A
gene id: 9483:SEC22A
uniprot id: U3FPJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9483:SCAMP1
gene id: 9483:SCAMP1
uniprot id: F6TX27
uniprot id: F6U6N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9483:CCNJ
gene id: 9483:CCNJ
uniprot id: F6YW04
uniprot id: F7I9P2
names: Similarity
messages: Belongs to the cyclin family.

9483:STRN
gene id: 9483:STRN
uniprot id: F7GIV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9483:TFCP2
gene id: 9483:TFCP2
uniprot id: F7H1F4
uniprot id: U3EB10
uniprot id: U3EZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9483:RRS1
gene id: 9483:RRS1
uniprot id: F7HZW9
uniprot id: U3FNM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9483:SDE2
gene id: 9483:SDE2
uniprot id: F7IKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

9483:KEAP1
gene id: 9483:KEAP1
uniprot id: F7H3A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

9483:DOCK1
gene id: 9483:DOCK1
uniprot id: U3CX33
names: Similarity
messages: Belongs to the DOCK family.

9483:ATP5PB
gene id: 9483:ATP5PB
uniprot id: F7GCT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9483:TGFBR2
gene id: 9483:TGFBR2
uniprot id: A0A2R8MMC4
uniprot id: F6ZQQ5
uniprot id: F6ZRN4
uniprot id: U3B8Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

9483:SKAP2
gene id: 9483:SKAP2
uniprot id: A0A8I3WDR4
uniprot id: F7DPK3
names: Similarity
messages: Belongs to the SKAP family.

9483:KCNJ6
gene id: 9483:KCNJ6
uniprot id: F7BNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9483:LOC100409753
gene id: 9483:LOC100409753
uniprot id: A0A2R8M4T8
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:GNB3
gene id: 9483:GNB3
uniprot id: F6VBL9
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9483:SPCS3
gene id: 9483:SPCS3
uniprot id: F7HHH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane

9483:EFNB1
gene id: 9483:EFNB1
uniprot id: F7IDP5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:OR2T27
gene id: 9483:OR2T27
uniprot id: F7I327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:AQP11
gene id: 9483:AQP11
uniprot id: A0A2R8MJH3
uniprot id: A0A2R8MP89
uniprot id: F7ELM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

9483:SLC31A1
gene id: 9483:SLC31A1
uniprot id: U3B0D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9483:VSX1
gene id: 9483:VSX1
uniprot id: A0A8I3WX80
names: Subcellular Location Annotation
messages: Nucleus

9483:CFAP69
gene id: 9483:CFAP69
uniprot id: B0VXE6
names: Function
names: Subcellular Location Annotation
messages: Cilium- and flagellum-associated protein (By similarity). In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability (By similarity).
messages: cilium
messages: flagellum

9483:LOC100406761
gene id: 9483:LOC100406761
uniprot id: A0A8I4A2X5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9483:RHBDD1
gene id: 9483:RHBDD1
uniprot id: F7HNU5
names: Subcellular Location Annotation
messages: Membrane

9483:CAMK2N1
gene id: 9483:CAMK2N1
uniprot id: F7GNI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

9483:LOC100398400
gene id: 9483:LOC100398400
uniprot id: A0A2R8NCV0
uniprot id: F6X8Z8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9483:PHETA2
gene id: 9483:PHETA2
uniprot id: H9KVS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

9483:DUS4L
gene id: 9483:DUS4L
uniprot id: F6RTL3
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9483:RUNX1
gene id: 9483:RUNX1
uniprot id: F7IM07
uniprot id: U3FHT7
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9483:CLDN8
gene id: 9483:CLDN8
uniprot id: U3DEN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:PON3
gene id: 9483:PON3
uniprot id: U3DKS0
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9483:OOSP2
gene id: 9483:OOSP2
uniprot id: A0A2R8MBX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

9483:CNOT6
gene id: 9483:CNOT6
uniprot id: U3FFQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9483:PPIC
gene id: 9483:PPIC
uniprot id: F7IA22
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:OGT
gene id: 9483:OGT
uniprot id: F7G0L9
uniprot id: U3EFN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

9483:DLL3
gene id: 9483:DLL3
uniprot id: F7INL2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:ST7
gene id: 9483:ST7
uniprot id: F7HBK2
uniprot id: Q2QLG2
uniprot id: Q2QLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9483:HSPD1
gene id: 9483:HSPD1
uniprot id: U3D4H6
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9483:RRAGB
gene id: 9483:RRAGB
uniprot id: F7BFD1
uniprot id: F7BGE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9483:ACO1
gene id: 9483:ACO1
uniprot id: F7IIU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

9483:CENPK
gene id: 9483:CENPK
uniprot id: A0A8I3W2N6
uniprot id: A0A8J8XEV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9483:GSTZ1
gene id: 9483:GSTZ1
uniprot id: A0A7G0XAN9
uniprot id: A0A8I3WCX3
uniprot id: F7A4H9
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9483:S100A1
gene id: 9483:S100A1
uniprot id: U3D200
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Mitochondrion

9483:GJA4
gene id: 9483:GJA4
uniprot id: F7ARL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:MB
gene id: 9483:MB
uniprot id: F6PMG4
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

9483:SYNGR1
gene id: 9483:SYNGR1
uniprot id: A0A2R8P6T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9483:DENND6A
gene id: 9483:DENND6A
uniprot id: U3BSL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

9483:PCNX4
gene id: 9483:PCNX4
uniprot id: F7HUM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9483:UCHL3
gene id: 9483:UCHL3
uniprot id: U3D094
uniprot id: U3FD52
names: Similarity
messages: Belongs to the peptidase C12 family.

9483:BSPRY
gene id: 9483:BSPRY
uniprot id: F6PLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:CDS1
gene id: 9483:CDS1
uniprot id: A0A5F4VTJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:HAGH
gene id: 9483:HAGH
uniprot id: Q28333
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A mitochondrial longer isoform in the N-terminus has been proven to exist in orthologs.
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cloning artifact.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.
messages: Testis.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

9483:XPO1
gene id: 9483:XPO1
uniprot id: A0A8I3WWM2
uniprot id: F7A6J3
uniprot id: U3DD16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9483:ASB2
gene id: 9483:ASB2
uniprot id: F7IRC8
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:FGF10
gene id: 9483:FGF10
uniprot id: A0A2R8M3J4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:MINAR2
gene id: 9483:MINAR2
uniprot id: F7GS61
names: Similarity
messages: Belongs to the MINAR family.

9483:CORO6
gene id: 9483:CORO6
uniprot id: F7CGH9
uniprot id: U3EM49
names: Similarity
messages: Belongs to the WD repeat coronin family.

9483:PTP4A2
gene id: 9483:PTP4A2
uniprot id: F7EJC3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9483:SGTA
gene id: 9483:SGTA
uniprot id: U3ELV4
names: Similarity
messages: Belongs to the SGT family.

9483:UCP3
gene id: 9483:UCP3
uniprot id: A0A2R8MR09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:RTBDN
gene id: 9483:RTBDN
uniprot id: U3EWX7
names: Similarity
messages: Belongs to the folate receptor family.

9483:ADAMTS5
gene id: 9483:ADAMTS5
uniprot id: F6VXD6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9483:MRAP2
gene id: 9483:MRAP2
uniprot id: F7HEG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:REEP4
gene id: 9483:REEP4
uniprot id: U3D454
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:GRINA
gene id: 9483:GRINA
uniprot id: F7B131
names: Subcellular Location Annotation
messages: Membrane

9483:GARS1
gene id: 9483:GARS1
uniprot id: U3FUA7
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9483:RNF135
gene id: 9483:RNF135
uniprot id: A0A8I4A0X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:DAZAP2
gene id: 9483:DAZAP2
uniprot id: F7FWV5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

9483:S100A8
gene id: 9483:S100A8
uniprot id: A0A8J8YBA8
names: Similarity
messages: Belongs to the S-100 family.

9483:MNAT1
gene id: 9483:MNAT1
uniprot id: F7I1L8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9483:HNF1B
gene id: 9483:HNF1B
uniprot id: U3CQ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9483:TBX21
gene id: 9483:TBX21
uniprot id: A0A2R8MZJ4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:CFI
gene id: 9483:CFI
uniprot id: F6Y8T3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:QPCT
gene id: 9483:QPCT
uniprot id: A0A8I3X3E4
uniprot id: F6PIC3
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9483:FAM234B
gene id: 9483:FAM234B
uniprot id: F7ILE3
names: Similarity
messages: Belongs to the FAM234 family.

9483:LOC103792196
gene id: 9483:LOC103792196
uniprot id: A0A2R8MUI6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:PRPF18
gene id: 9483:PRPF18
uniprot id: U3EI83
uniprot id: U3FGS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9483:TRIAP1
gene id: 9483:TRIAP1
uniprot id: F7I4Y8
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9483:RPL11
gene id: 9483:RPL11
uniprot id: U3EM31
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9483:CLP1
gene id: 9483:CLP1
uniprot id: U3BTP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

9483:DISP3
gene id: 9483:DISP3
uniprot id: A0A5F4WFU8
names: Subcellular Location Annotation
messages: Membrane

9483:DCTN2
gene id: 9483:DCTN2
uniprot id: U3EBE7
uniprot id: U3F5Q3
uniprot id: U3FJH5
names: Function
names: Similarity
messages: Belongs to the dynactin subunit 2 family.
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

9483:LOC100389619
gene id: 9483:LOC100389619
uniprot id: F7HAK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9483:CASK
gene id: 9483:CASK
uniprot id: A0A2R8MLT5
uniprot id: A0A2R8MUH7
uniprot id: A0A2R8P5U8
uniprot id: A0A8J8YHG2
uniprot id: F6W7Q7
uniprot id: U3BRM7
uniprot id: U3CM89
uniprot id: U3DET2
uniprot id: U3EY01
names: Similarity
messages: Belongs to the MAGUK family.

9483:LSM8
gene id: 9483:LSM8
uniprot id: A0A8I3WM72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9483:ATP6V0D2
gene id: 9483:ATP6V0D2
uniprot id: F7GSS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9483:TNFRSF21
gene id: 9483:TNFRSF21
uniprot id: F6QC41
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MOG
gene id: 9483:MOG
uniprot id: Q29ZQ1
uniprot id: U3E6A3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion (By similarity).
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

9483:TNK2
gene id: 9483:TNK2
uniprot id: A0A5F4W345
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9483:RLN3
gene id: 9483:RLN3
uniprot id: F7I420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9483:LDAH
gene id: 9483:LDAH
uniprot id: U3DI97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

9483:CHRNA7
gene id: 9483:CHRNA7
uniprot id: U3EQP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:SMARCD3
gene id: 9483:SMARCD3
uniprot id: U3CD19
uniprot id: U3EBF1
names: Similarity
messages: Belongs to the SMARCD family.

9483:SOAT1
gene id: 9483:SOAT1
uniprot id: F7FD82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:PTPN11
gene id: 9483:PTPN11
uniprot id: F7ICW6
uniprot id: U3C430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9483:KATNA1
gene id: 9483:KATNA1
uniprot id: F7HIN0
uniprot id: U3FQJ4
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

9483:TBX5
gene id: 9483:TBX5
uniprot id: F7I9S7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:LOC100403393
gene id: 9483:LOC100403393
uniprot id: U3CN13
names: Similarity
messages: Belongs to the cytochrome b5 family.

9483:TWF1
gene id: 9483:TWF1
uniprot id: A0A8J8XM35
uniprot id: A0A8J8XXN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9483:TOMM40L
gene id: 9483:TOMM40L
uniprot id: F7F8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9483:NCBP1
gene id: 9483:NCBP1
uniprot id: A0A2R8MCM2
uniprot id: F7GRU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9483:GPX7
gene id: 9483:GPX7
uniprot id: F7I0C6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9483:SPSB2
gene id: 9483:SPSB2
uniprot id: F7AY68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

9483:ETNPPL
gene id: 9483:ETNPPL
uniprot id: A0A5F4W855
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9483:LTN1
gene id: 9483:LTN1
uniprot id: A0A2R8N1H3
uniprot id: A0A2R8PEB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

9483:BEX4
gene id: 9483:BEX4
uniprot id: F7H6P0
names: Similarity
messages: Belongs to the BEX family.

9483:NGRN
gene id: 9483:NGRN
uniprot id: F6Z313
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9483:SPIN1
gene id: 9483:SPIN1
uniprot id: F7GKT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

9483:MT4
gene id: 9483:MT4
uniprot id: F7ISN0
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9483:ZCCHC4
gene id: 9483:ZCCHC4
uniprot id: F7H362
uniprot id: U3C004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

9483:KDELR3
gene id: 9483:KDELR3
uniprot id: U3CH29
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SLC25A6
gene id: 9483:SLC25A6
uniprot id: U3CNV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9483:NUDT5
gene id: 9483:NUDT5
uniprot id: U3DDE9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9483:AREG
gene id: 9483:AREG
uniprot id: F7CE46
uniprot id: U3D851
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:LOC100402310
gene id: 9483:LOC100402310
uniprot id: F7CSR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:PKIB
gene id: 9483:PKIB
uniprot id: A0A5F4W598
uniprot id: A0A8I3X2R3
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9483:ARSJ
gene id: 9483:ARSJ
uniprot id: A0A8I3WK19
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9483:CLK4
gene id: 9483:CLK4
uniprot id: F7BCE4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:H1F0
gene id: 9483:H1F0
uniprot id: F7IAQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9483:LOC100406796
gene id: 9483:LOC100406796
uniprot id: F7G6P0
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:SLC2A2
gene id: 9483:SLC2A2
uniprot id: F7AN96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Membrane

9483:EML5
gene id: 9483:EML5
uniprot id: F7ESY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
messages: cytoskeleton

9483:LOC100402218
gene id: 9483:LOC100402218
uniprot id: F6Y6J2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

9483:IL13RA1
gene id: 9483:IL13RA1
uniprot id: F7GLB4
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.

9483:LOC100397351
gene id: 9483:LOC100397351
uniprot id: F7IE80
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:SHROOM4
gene id: 9483:SHROOM4
uniprot id: A0A2R8P863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9483:TOP1
gene id: 9483:TOP1
uniprot id: F6STR2
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9483:PRM2
gene id: 9483:PRM2
uniprot id: Q28337
uniprot id: U3B7U7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protamine P2 family.
messages: Chromosome
messages: Interacts with TDRP.
messages: Nucleus
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
messages: Proteolytic processing into mature chains is required for histone eviction during spermatogenesis. Transition proteins (TNP1 and TNP2) are required for processing.
messages: Testis.

9483:RPS29
gene id: 9483:RPS29
uniprot id: F7D3P5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

9483:RAB9B
gene id: 9483:RAB9B
uniprot id: F7GKL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

9483:EPHA7
gene id: 9483:EPHA7
uniprot id: F6XPG2
uniprot id: U3DW98
names: Subcellular Location Annotation
messages: Membrane

9483:ZNF496
gene id: 9483:ZNF496
uniprot id: A0A5K1U0Y8
uniprot id: U3BDK5
names: Subcellular Location Annotation
messages: Nucleus

9483:FAM32A
gene id: 9483:FAM32A
uniprot id: U3D055
names: Similarity
messages: Belongs to the FAM32 family.

9483:ATPAF2
gene id: 9483:ATPAF2
uniprot id: U3D1C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9483:NRTN
gene id: 9483:NRTN
uniprot id: F7ICQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9483:MRPL44
gene id: 9483:MRPL44
uniprot id: U3DQE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

9483:NOX1
gene id: 9483:NOX1
uniprot id: F7ID45
uniprot id: U3BPB7
names: Subcellular Location Annotation
messages: Membrane

9483:FTHL17
gene id: 9483:FTHL17
uniprot id: F7IIS6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9483:RPL37
gene id: 9483:RPL37
uniprot id: F6YVB8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9483:LIPT1
gene id: 9483:LIPT1
uniprot id: F6UBC6
names: Similarity
messages: Belongs to the LplA family.

9483:PSMA4
gene id: 9483:PSMA4
uniprot id: U3EX30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:PHC1
gene id: 9483:PHC1
uniprot id: A0A8I3W0S8
uniprot id: F7HWG9
names: Subcellular Location Annotation
messages: Nucleus

9483:CXCL12
gene id: 9483:CXCL12
uniprot id: A0A8I3WCR3
uniprot id: F6SEQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9483:KHDRBS1
gene id: 9483:KHDRBS1
uniprot id: U3DMI6
names: Similarity
messages: Belongs to the KHDRBS family.

9483:LRRC8D
gene id: 9483:LRRC8D
uniprot id: U3BD29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9483:PSMA7
gene id: 9483:PSMA7
uniprot id: U3AXR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9483:DCTN6
gene id: 9483:DCTN6
uniprot id: F7HWQ5
uniprot id: U3EUQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9483:CYP11B2
gene id: 9483:CYP11B2
uniprot id: A0A8I3WBU5
uniprot id: F7HJJ9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9483:STIM2
gene id: 9483:STIM2
uniprot id: A0A5F4WLF5
uniprot id: F7EAG6
uniprot id: F7EAI3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:ACP1
gene id: 9483:ACP1
uniprot id: U3CJJ6
uniprot id: U3F3I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9483:SUFU
gene id: 9483:SUFU
uniprot id: F6U4B5
uniprot id: U3FX06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9483:CFL2
gene id: 9483:CFL2
uniprot id: F7DMB4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9483:TRMT10C
gene id: 9483:TRMT10C
uniprot id: A0A5F4VZF9
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9483:ATG2B
gene id: 9483:ATG2B
uniprot id: U3DAG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9483:LOC100400279
gene id: 9483:LOC100400279
uniprot id: F7EQC1
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9483:ANP32E
gene id: 9483:ANP32E
uniprot id: F7HKP3
uniprot id: F7IR97
names: Similarity
messages: Belongs to the ANP32 family.

9483:CRYBB3
gene id: 9483:CRYBB3
uniprot id: F7IHF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9483:MRPL47
gene id: 9483:MRPL47
uniprot id: F7GBP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9483:HTR2B
gene id: 9483:HTR2B
uniprot id: F6U6Y0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MPDZ.
messages: Membrane
messages: synaptosome

9483:LOC103791113
gene id: 9483:LOC103791113
uniprot id: A0A2R8MA75
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9483:CTPS1
gene id: 9483:CTPS1
uniprot id: F6SKL8
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9483:DDX54
gene id: 9483:DDX54
uniprot id: U3CWT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

9483:LOC108587827
gene id: 9483:LOC108587827
uniprot id: A0A8I3W8R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9483:MMGT1
gene id: 9483:MMGT1
uniprot id: U3F6U2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9483:TRIM21
gene id: 9483:TRIM21
uniprot id: F7ALH2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:MTMR10
gene id: 9483:MTMR10
uniprot id: U3E8V8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9483:IQCD
gene id: 9483:IQCD
uniprot id: F7DQE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9483:PIAS1
gene id: 9483:PIAS1
uniprot id: U3D8K3
names: Similarity
messages: Belongs to the PIAS family.

9483:TMEFF2
gene id: 9483:TMEFF2
uniprot id: U3ETB1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:POLR1H
gene id: 9483:POLR1H
uniprot id: F7G0Q7
uniprot id: X5IYV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

9483:SPIRE1
gene id: 9483:SPIRE1
uniprot id: A0A8J8YH72
uniprot id: U3D237
uniprot id: U3D3K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

9483:DACT3
gene id: 9483:DACT3
uniprot id: F6PHE1
names: Similarity
messages: Belongs to the dapper family.

9483:PSMC5
gene id: 9483:PSMC5
uniprot id: F7E548
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9483:FEZ1
gene id: 9483:FEZ1
uniprot id: A0A2R8M9E2
names: Similarity
messages: Belongs to the zygin family.

9483:PITX3
gene id: 9483:PITX3
uniprot id: F7GQI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9483:ZDHHC24
gene id: 9483:ZDHHC24
uniprot id: U3EQW3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:MNF1
gene id: 9483:MNF1
uniprot id: F6ZAL9
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9483:SUSD5
gene id: 9483:SUSD5
uniprot id: A0A2R8P1M3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CDNF
gene id: 9483:CDNF
uniprot id: F7I7V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9483:E2F6
gene id: 9483:E2F6
uniprot id: F6PNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9483:DBT
gene id: 9483:DBT
uniprot id: U3CGC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9483:HNRNPA2B1
gene id: 9483:HNRNPA2B1
uniprot id: F7HPY3
uniprot id: F7HPZ0
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

9483:ZNF287
gene id: 9483:ZNF287
uniprot id: A0A8I3WZE2
names: Subcellular Location Annotation
messages: Nucleus

9483:MAP2K4
gene id: 9483:MAP2K4
uniprot id: A0A2R8MD99
uniprot id: A0A2R8MIZ6
uniprot id: A0A8I3WWX8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:DEFB124
gene id: 9483:DEFB124
uniprot id: A0A5F4W2I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9483:KARS1
gene id: 9483:KARS1
uniprot id: F7I4R7
uniprot id: U3D440
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9483:CHRDL2
gene id: 9483:CHRDL2
uniprot id: A0A8I4A384
names: Subcellular Location Annotation
messages: Secreted

9483:TARDBP
gene id: 9483:TARDBP
uniprot id: F7CL81
names: Subcellular Location Annotation
messages: Nucleus

9483:RAB4A
gene id: 9483:RAB4A
uniprot id: A0A5F4VSH5
uniprot id: A0A5F4WBU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9483:GPR156
gene id: 9483:GPR156
uniprot id: A0A2R8M683
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9483:UBE2T
gene id: 9483:UBE2T
uniprot id: U3EFD1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9483:DEDD2
gene id: 9483:DEDD2
uniprot id: U3D5N1
names: Subcellular Location Annotation
messages: nucleolus

9483:NIT1
gene id: 9483:NIT1
uniprot id: U3BSW4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9483:LOC100386161
gene id: 9483:LOC100386161
uniprot id: F6Z0Y9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9483:APRT
gene id: 9483:APRT
uniprot id: U3CZ73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

9483:LOC100404838
gene id: 9483:LOC100404838
uniprot id: A0A2R8PER2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:KYAT3
gene id: 9483:KYAT3
uniprot id: U3EF63
names: Subunit
messages: Homodimer.

9483:SLC10A3
gene id: 9483:SLC10A3
uniprot id: B0KWT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9483:ZNF263
gene id: 9483:ZNF263
uniprot id: F7EWU1
names: Subcellular Location Annotation
messages: Nucleus

9483:VPS29
gene id: 9483:VPS29
uniprot id: F6UAL0
uniprot id: F7HLW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9483:ZKSCAN1
gene id: 9483:ZKSCAN1
uniprot id: F6W5I1
names: Subcellular Location Annotation
messages: Nucleus

9483:COA5
gene id: 9483:COA5
uniprot id: A0A8I4A0R0
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9483:GOLT1A
gene id: 9483:GOLT1A
uniprot id: F7IRX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

9483:MOB3B
gene id: 9483:MOB3B
uniprot id: F6WEX5
names: Similarity
messages: Belongs to the MOB1/phocein family.

9483:APLNR
gene id: 9483:APLNR
uniprot id: F7I1H0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:TRAF6
gene id: 9483:TRAF6
uniprot id: F7ES31
uniprot id: U3DER5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

9483:SNU13
gene id: 9483:SNU13
uniprot id: H9KVU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9483:DOCK4
gene id: 9483:DOCK4
uniprot id: U3CZS7
uniprot id: U3F8D9
names: Similarity
messages: Belongs to the DOCK family.

9483:CHD7
gene id: 9483:CHD7
uniprot id: F6VM65
uniprot id: U3EHJ9
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9483:USO1
gene id: 9483:USO1
uniprot id: A0A2R8MUA2
uniprot id: F6Q6L3
uniprot id: F6Q6W2
uniprot id: U3ETI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

9483:PI4KB
gene id: 9483:PI4KB
uniprot id: B0KWC1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Endomembrane system
messages: Golgi apparatus
messages: Golgi apparatus membrane
messages: Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ.
messages: Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (By similarity). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3. Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (By similarity). Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (By similarity). Interacts with ATG9A.
messages: Mitochondrion outer membrane
messages: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity).
messages: Rough endoplasmic reticulum membrane

9483:PTCD2
gene id: 9483:PTCD2
uniprot id: F6WCE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9483:GPRC5D
gene id: 9483:GPRC5D
uniprot id: A0A2R8MZ45
uniprot id: A0A8I3VZ43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:GMFB
gene id: 9483:GMFB
uniprot id: U3EZ43
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9483:PLA2G4A
gene id: 9483:PLA2G4A
uniprot id: A0A8J8Y9K6
uniprot id: F7IKI8
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

9483:ELAC1
gene id: 9483:ELAC1
uniprot id: U3DIH8
names: Subunit
messages: Homodimer.

9483:ARRB2
gene id: 9483:ARRB2
uniprot id: F7ISF7
names: Similarity
messages: Belongs to the arrestin family.

9483:STX16
gene id: 9483:STX16
uniprot id: U3DL97
uniprot id: U3FTM0
names: Similarity
messages: Belongs to the syntaxin family.

9483:GABRB1
gene id: 9483:GABRB1
uniprot id: F7IFX8
uniprot id: U3DHM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:ME2
gene id: 9483:ME2
uniprot id: F7F107
uniprot id: U3EUL8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9483:NAA38
gene id: 9483:NAA38
uniprot id: F7DEK6
uniprot id: F7DEN2
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

9483:CYSLTR2
gene id: 9483:CYSLTR2
uniprot id: A0A8I4A2X1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:CD34
gene id: 9483:CD34
uniprot id: Q76II1
names: Subcellular Location Annotation
messages: Membrane

9483:MMS19
gene id: 9483:MMS19
uniprot id: U3C261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9483:NKAIN2
gene id: 9483:NKAIN2
uniprot id: U3C7Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9483:HOXC9
gene id: 9483:HOXC9
uniprot id: F7I5W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9483:SNRNP27
gene id: 9483:SNRNP27
uniprot id: F7F836
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

9483:MND1
gene id: 9483:MND1
uniprot id: F7HA07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

9483:RUVBL1
gene id: 9483:RUVBL1
uniprot id: F7GWQ2
uniprot id: U3C0J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9483:ESD
gene id: 9483:ESD
uniprot id: U3DYQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9483:PDGFC
gene id: 9483:PDGFC
uniprot id: A0A8I3W9P2
uniprot id: F7HUW5
uniprot id: U3DUG3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:RPL38
gene id: 9483:RPL38
uniprot id: A0A5F4W0P3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9483:SPC24
gene id: 9483:SPC24
uniprot id: F7HYV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9483:ERBB4
gene id: 9483:ERBB4
uniprot id: F7HB76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9483:GDI2
gene id: 9483:GDI2
uniprot id: F7BTK1
uniprot id: U3C6M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9483:LOC100400584
gene id: 9483:LOC100400584
uniprot id: A0A5F4W1M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:TNFSF14
gene id: 9483:TNFSF14
uniprot id: A0A8I3WAJ4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:MCRIP2
gene id: 9483:MCRIP2
uniprot id: F7BDC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

9483:SPOCK2
gene id: 9483:SPOCK2
uniprot id: U3CZB2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CLPS
gene id: 9483:CLPS
uniprot id: F7HYJ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

9483:NME2
gene id: 9483:NME2
uniprot id: A0A5F4VZ46
uniprot id: F6YGJ2
names: Similarity
messages: Belongs to the NDK family.

9483:APOA1
gene id: 9483:APOA1
uniprot id: B0KWR1
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9483:ASXL1
gene id: 9483:ASXL1
uniprot id: U3CD57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9483:GBX2
gene id: 9483:GBX2
uniprot id: A0A2R8NEK0
names: Subcellular Location Annotation
messages: Nucleus

9483:ALDH1A1
gene id: 9483:ALDH1A1
uniprot id: A0A8I3WAY2
uniprot id: F7IE41
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:PAPPA2
gene id: 9483:PAPPA2
uniprot id: F7E7D1
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:CDC42
gene id: 9483:CDC42
uniprot id: F7HMJ4
uniprot id: U3DLZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: centrosome

9483:SPAM1
gene id: 9483:SPAM1
uniprot id: F7GMG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9483:SCAI
gene id: 9483:SCAI
uniprot id: A0A2R8MUA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAI family.
messages: Cytoplasm
messages: Interacts with DIAPH1. Forms a nuclear ternary complex with MRTFA and SRF.
messages: Nucleus
messages: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity.

9483:CWC15
gene id: 9483:CWC15
uniprot id: F6PQC3
names: Similarity
messages: Belongs to the CWC15 family.

9483:NUF2
gene id: 9483:NUF2
uniprot id: F6PHA6
names: Similarity
messages: Belongs to the NUF2 family.

9483:GIMAP1
gene id: 9483:GIMAP1
uniprot id: F6Q1Z7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9483:RBM47
gene id: 9483:RBM47
uniprot id: U3BG53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Nucleus

9483:LOC100413303
gene id: 9483:LOC100413303
uniprot id: F6QZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9483:ST6GALNAC6
gene id: 9483:ST6GALNAC6
uniprot id: F7A279
uniprot id: U3DSI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9483:ACP7
gene id: 9483:ACP7
uniprot id: F7BW71
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

9483:KRT18
gene id: 9483:KRT18
uniprot id: F6RWB1
names: Similarity
messages: Belongs to the intermediate filament family.

9483:DUSP26
gene id: 9483:DUSP26
uniprot id: F7HXW2
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9483:EPHA3
gene id: 9483:EPHA3
uniprot id: U3DED6
names: Subcellular Location Annotation
messages: Membrane

9483:STARD5
gene id: 9483:STARD5
uniprot id: U3BTT1
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9483:CLIC5
gene id: 9483:CLIC5
uniprot id: A0A2R8MTD2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9483:NQO1
gene id: 9483:NQO1
uniprot id: A0A2R8MT21
uniprot id: F7EKA7
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9483:PDE1B
gene id: 9483:PDE1B
uniprot id: A0A8I3WF54
uniprot id: F7ISI9
uniprot id: U3DNA4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:RIN1
gene id: 9483:RIN1
uniprot id: A0A8I3WU98
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9483:LOC100394746
gene id: 9483:LOC100394746
uniprot id: F7HQ77
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9483:NUDT18
gene id: 9483:NUDT18
uniprot id: F6ZVD3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9483:PPP2R3C
gene id: 9483:PPP2R3C
uniprot id: F7EHK2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:MARK3
gene id: 9483:MARK3
uniprot id: U3E279
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9483:SUSD4
gene id: 9483:SUSD4
uniprot id: F6ZEW8
uniprot id: U3DA72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:DACT1
gene id: 9483:DACT1
uniprot id: U3B9U5
uniprot id: U3BSZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm

9483:SLC26A7
gene id: 9483:SLC26A7
uniprot id: F7G2J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9483:PDE7B
gene id: 9483:PDE7B
uniprot id: A0A2R8MIN9
uniprot id: F7DVY7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:MRPS25
gene id: 9483:MRPS25
uniprot id: F7HYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9483:AMACR
gene id: 9483:AMACR
uniprot id: F7I3Q5
names: Similarity
messages: Belongs to the CoA-transferase III family.

9483:C2H5orf63
gene id: 9483:C2H5orf63
uniprot id: F7E4F2
names: Similarity
messages: Belongs to the glutaredoxin family.

9483:ATP6V0B
gene id: 9483:ATP6V0B
uniprot id: A0A8J8XU00
uniprot id: U3E3T0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9483:LOC100410823
gene id: 9483:LOC100410823
uniprot id: F7F1S3
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9483:PIGU
gene id: 9483:PIGU
uniprot id: A0A8J8YIQ4
uniprot id: U3EYS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:COG3
gene id: 9483:COG3
uniprot id: U3FGZ3
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

9483:EBAG9
gene id: 9483:EBAG9
uniprot id: U3DJE5
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

9483:LSM4
gene id: 9483:LSM4
uniprot id: F7HQY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9483:TMEM126B
gene id: 9483:TMEM126B
uniprot id: F7HZV3
names: Subcellular Location Annotation
messages: Membrane

9483:TFR2
gene id: 9483:TFR2
uniprot id: F7H9B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9483:SLC25A40
gene id: 9483:SLC25A40
uniprot id: U3F7R9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9483:ERAL1
gene id: 9483:ERAL1
uniprot id: A0A2R8PMP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

9483:NASP
gene id: 9483:NASP
uniprot id: F7B1R6
uniprot id: U3F6L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9483:REN
gene id: 9483:REN
uniprot id: Q9TSZ1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.
messages: Interacts with ATP6AP2.
messages: Membrane
messages: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
messages: Secreted

9483:LOX
gene id: 9483:LOX
uniprot id: A0A2R8MXE7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9483:EPB41
gene id: 9483:EPB41
uniprot id: F7F4N1
uniprot id: F7G9A8
uniprot id: F7G9D6
uniprot id: U3F3W9
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex

9483:TSEN34
gene id: 9483:TSEN34
uniprot id: B0VXI7
uniprot id: U3EXA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9483:DAZL
gene id: 9483:DAZL
uniprot id: Q9BGN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM DAZ family.
messages: Cytoplasm
messages: Homodimer and heterodimer. Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2 Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets (By similarity).
messages: Nucleus
messages: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).
messages: Testis specific.
messages: The DAZ domain mediates the interaction with DAZAP1 and DAZAP2.

9483:SPO11
gene id: 9483:SPO11
uniprot id: F7E4F8
names: Similarity
messages: Belongs to the TOP6A family.

9483:RAB14
gene id: 9483:RAB14
uniprot id: F7BFK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9483:TLCD5
gene id: 9483:TLCD5
uniprot id: F7IGM9
names: Subcellular Location Annotation
messages: Membrane

9483:IKBKE
gene id: 9483:IKBKE
uniprot id: F7IAT5
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ZPR1
gene id: 9483:ZPR1
uniprot id: B0KWQ8
names: Similarity
messages: Belongs to the ZPR1 family.

9483:ECE1
gene id: 9483:ECE1
uniprot id: U3E5A6
names: Function
messages: Converts big endothelin-1 to endothelin-1.

9483:FLNB
gene id: 9483:FLNB
uniprot id: A0A2R8MU25
uniprot id: A0A8J8XD29
uniprot id: A0A8J8Y4Q1
uniprot id: F6R327
uniprot id: U3D5Q5
uniprot id: U3DG44
names: Similarity
messages: Belongs to the filamin family.

9483:LOC100396744
gene id: 9483:LOC100396744
uniprot id: U3CM30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:EMP2
gene id: 9483:EMP2
uniprot id: F7I0U4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9483:UBALD1
gene id: 9483:UBALD1
uniprot id: A0A2R8MPE1
names: Similarity
messages: Belongs to the UBALD family.

9483:COX6A2
gene id: 9483:COX6A2
uniprot id: F6VFX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9483:MSRB2
gene id: 9483:MSRB2
uniprot id: U3FFK9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9483:PDE6C
gene id: 9483:PDE6C
uniprot id: F6V1P7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9483:SLC35B2
gene id: 9483:SLC35B2
uniprot id: U3BWQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9483:TRIM23
gene id: 9483:TRIM23
uniprot id: F7HBN0
uniprot id: U3BWI0
names: Subcellular Location Annotation
messages: Cytoplasm

9483:CCNL2
gene id: 9483:CCNL2
uniprot id: A0A2R8ML64
uniprot id: F7FXM5
names: Similarity
messages: Belongs to the cyclin family.

9483:EIF5
gene id: 9483:EIF5
uniprot id: A0A5F4WHF4
uniprot id: F7ICJ0
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

9483:VOPP1
gene id: 9483:VOPP1
uniprot id: U3BC45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
messages: Membrane

9483:TMEM234
gene id: 9483:TMEM234
uniprot id: U3EK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

9483:RHBDL3
gene id: 9483:RHBDL3
uniprot id: U3F0C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

9483:DDX47
gene id: 9483:DDX47
uniprot id: U3D605
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9483:CDA
gene id: 9483:CDA
uniprot id: A0A2R8MEI9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

9483:VMA21
gene id: 9483:VMA21
uniprot id: F6S8Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

9483:EMP1
gene id: 9483:EMP1
uniprot id: F7ILG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9483:RPL9
gene id: 9483:RPL9
uniprot id: F6Z0T6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

9483:MKX
gene id: 9483:MKX
uniprot id: F7FZ99
names: Subcellular Location Annotation
messages: Nucleus

9483:ATP6AP2
gene id: 9483:ATP6AP2
uniprot id: F7GIK4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9483:PPAT
gene id: 9483:PPAT
uniprot id: A0A2R8N0A3
uniprot id: U3AS03
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9483:TNMD
gene id: 9483:TNMD
uniprot id: F6XK62
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9483:GALNT16
gene id: 9483:GALNT16
uniprot id: F7HF93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:PEA15
gene id: 9483:PEA15
uniprot id: F7ICU5
names: Subcellular Location Annotation
messages: Cytoplasm

9483:CYFIP2
gene id: 9483:CYFIP2
uniprot id: F7I1T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

9483:KRT3
gene id: 9483:KRT3
uniprot id: L7N0W8
names: Similarity
messages: Belongs to the intermediate filament family.

9483:LOC100895074
gene id: 9483:LOC100895074
uniprot id: A0A8I3WPI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:SPTB
gene id: 9483:SPTB
uniprot id: U3E8E8
names: Similarity
messages: Belongs to the spectrin family.

9483:SAA4
gene id: 9483:SAA4
uniprot id: A0A8I3WMR8
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9483:BCL7B
gene id: 9483:BCL7B
uniprot id: U3D0P2
names: Similarity
messages: Belongs to the BCL7 family.

9483:CNN3
gene id: 9483:CNN3
uniprot id: F7IS17
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9483:BRINP1
gene id: 9483:BRINP1
uniprot id: F6YUW3
names: Similarity
messages: Belongs to the BRINP family.

9483:MEF2B
gene id: 9483:MEF2B
uniprot id: U3F2R9
names: Subcellular Location Annotation
messages: Nucleus

9483:DSG1
gene id: 9483:DSG1
uniprot id: F7IT33
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9483:BUD31
gene id: 9483:BUD31
uniprot id: F7I7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9483:NDUFV3
gene id: 9483:NDUFV3
uniprot id: F7IRU9
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

9483:AGAP2
gene id: 9483:AGAP2
uniprot id: F6PYY5
uniprot id: F6PZU7
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9483:TGM6
gene id: 9483:TGM6
uniprot id: F7FUN4
uniprot id: F7FUQ2
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9483:GBP5
gene id: 9483:GBP5
uniprot id: F7E8X1
uniprot id: U3CSZ8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9483:URGCP
gene id: 9483:URGCP
uniprot id: A0A8I3X7B4
uniprot id: F7IDX1
uniprot id: F7IGB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9483:CDK10
gene id: 9483:CDK10
uniprot id: F7C8F5
uniprot id: U3CHA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ISCU
gene id: 9483:ISCU
uniprot id: U3DV20
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

9483:GPR25
gene id: 9483:GPR25
uniprot id: A0A5F4W8I4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:TJP2
gene id: 9483:TJP2
uniprot id: U3CA71
uniprot id: U3CSI5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9483:SAP30
gene id: 9483:SAP30
uniprot id: F7H7Z7
names: Similarity
messages: Belongs to the SAP30 family.

9483:ASB7
gene id: 9483:ASB7
uniprot id: U3EV99
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

9483:NMT2
gene id: 9483:NMT2
uniprot id: F6WQJ3
uniprot id: U3E393
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9483:TUT7
gene id: 9483:TUT7
uniprot id: F7GH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

9483:CSNK2A2
gene id: 9483:CSNK2A2
uniprot id: F6R0E2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:SLC7A3
gene id: 9483:SLC7A3
uniprot id: F6S3I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9483:ORAI3
gene id: 9483:ORAI3
uniprot id: F7I315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9483:TNFSF13B
gene id: 9483:TNFSF13B
uniprot id: F7FUZ6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:SLC5A12
gene id: 9483:SLC5A12
uniprot id: F7H2L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9483:COX4I2
gene id: 9483:COX4I2
uniprot id: F7IT30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9483:SET
gene id: 9483:SET
uniprot id: U3CYB5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:ELL2
gene id: 9483:ELL2
uniprot id: A0A8I3WES2
uniprot id: F7HG02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9483:CLDND2
gene id: 9483:CLDND2
uniprot id: A0A8I3W6Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9483:ND3
gene id: 9483:ND3
uniprot id: E1CJB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

9483:DPEP2
gene id: 9483:DPEP2
uniprot id: F7I379
names: Subcellular Location Annotation
messages: Membrane

9483:THTPA
gene id: 9483:THTPA
uniprot id: F7IH66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9483:NSG2
gene id: 9483:NSG2
uniprot id: U3CYN4
names: Similarity
messages: Belongs to the NSG family.

9483:SNX10
gene id: 9483:SNX10
uniprot id: A0A8I3WPZ9
uniprot id: F7IN97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9483:FSD1
gene id: 9483:FSD1
uniprot id: U3CCK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:CREG1
gene id: 9483:CREG1
uniprot id: U3FJ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9483:GHR
gene id: 9483:GHR
uniprot id: A0A5F4WE18
uniprot id: A0A8I3WN21
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

9483:BIRC2
gene id: 9483:BIRC2
uniprot id: U3D8L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

9483:PAN3
gene id: 9483:PAN3
uniprot id: F7FBS4
uniprot id: U3BH95
uniprot id: U3F559
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

9483:KYNU
gene id: 9483:KYNU
uniprot id: F6YX40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:HOXA1
gene id: 9483:HOXA1
uniprot id: B0VXK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9483:CST9
gene id: 9483:CST9
uniprot id: A0A8I3X0Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted

9483:CELSR2
gene id: 9483:CELSR2
uniprot id: U3FXU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

9483:MCTS1
gene id: 9483:MCTS1
uniprot id: F6W692
uniprot id: F7GTQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9483:GPR132
gene id: 9483:GPR132
uniprot id: F6T5G8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:CAMK1G
gene id: 9483:CAMK1G
uniprot id: F7G5K6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:EPB41L5
gene id: 9483:EPB41L5
uniprot id: U3EH61
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.

9483:HAUS3
gene id: 9483:HAUS3
uniprot id: U3ESN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9483:GALNT13
gene id: 9483:GALNT13
uniprot id: U3BX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9483:B3GAT1
gene id: 9483:B3GAT1
uniprot id: A0A5K1UD53
uniprot id: U3DLU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:TRPC7
gene id: 9483:TRPC7
uniprot id: F7I473
names: Subcellular Location Annotation
messages: Membrane

9483:ACAD10
gene id: 9483:ACAD10
uniprot id: F6SQR9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9483:SLC7A4
gene id: 9483:SLC7A4
uniprot id: F7I5E9
names: Subcellular Location Annotation
messages: Membrane

9483:MTERF4
gene id: 9483:MTERF4
uniprot id: F7H2N7
names: Similarity
messages: Belongs to the mTERF family.

9483:NFIX
gene id: 9483:NFIX
uniprot id: A0A2R8PEJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9483:THOC7
gene id: 9483:THOC7
uniprot id: A0A5F4W1V2
uniprot id: U3EI93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

9483:NT5E
gene id: 9483:NT5E
uniprot id: U3CHA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9483:TPRG1L
gene id: 9483:TPRG1L
uniprot id: U3DY61
names: Similarity
messages: Belongs to the TPRG1 family.

9483:FNBP1L
gene id: 9483:FNBP1L
uniprot id: F7G804
uniprot id: U3D9Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

9483:LTB
gene id: 9483:LTB
uniprot id: F7I2U6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:ALAS2
gene id: 9483:ALAS2
uniprot id: A0A5F4W670
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

9483:BBS7
gene id: 9483:BBS7
uniprot id: F7HY94
uniprot id: U3EBP5
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9483:PHF1
gene id: 9483:PHF1
uniprot id: A0A5F4VXJ4
uniprot id: F7IR10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9483:SESN2
gene id: 9483:SESN2
uniprot id: A0A2R8P1V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9483:TNFRSF1A
gene id: 9483:TNFRSF1A
uniprot id: F6UYQ7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:MED7
gene id: 9483:MED7
uniprot id: F7FJ65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9483:KCNG1
gene id: 9483:KCNG1
uniprot id: F6RE04
names: Subcellular Location Annotation
messages: Membrane

9483:PSKH1
gene id: 9483:PSKH1
uniprot id: F7I5C9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:YPEL1
gene id: 9483:YPEL1
uniprot id: A0A2R8MGE5
names: Similarity
messages: Belongs to the yippee family.

9483:NAB1
gene id: 9483:NAB1
uniprot id: F7IAX5
uniprot id: U3C899
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9483:ZSCAN25
gene id: 9483:ZSCAN25
uniprot id: F7IRV2
names: Subcellular Location Annotation
messages: Nucleus

9483:PPP1R14A
gene id: 9483:PPP1R14A
uniprot id: F6TA78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

9483:ANAPC11
gene id: 9483:ANAPC11
uniprot id: F7I8L7
names: Similarity
messages: Belongs to the RING-box family.

9483:RDH5
gene id: 9483:RDH5
uniprot id: F7IBF6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9483:LOC100403391
gene id: 9483:LOC100403391
uniprot id: F7FGL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:ANXA1
gene id: 9483:ANXA1
uniprot id: F7IL52
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9483:ESYT1
gene id: 9483:ESYT1
uniprot id: F6RL52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9483:TMEM237
gene id: 9483:TMEM237
uniprot id: U3BHM5
uniprot id: U3DWS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9483:GABRA4
gene id: 9483:GABRA4
uniprot id: A0A8I3WPF1
uniprot id: F7IFW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9483:LOC100415168
gene id: 9483:LOC100415168
uniprot id: A0A2R8MPB4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9483:IL22
gene id: 9483:IL22
uniprot id: A0A5F4W8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

9483:STAC2
gene id: 9483:STAC2
uniprot id: U3DBK6
names: Subcellular Location Annotation
messages: sarcolemma

9483:PAPOLA
gene id: 9483:PAPOLA
uniprot id: F7GTG4
uniprot id: F7HE64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

9483:LOC100395489
gene id: 9483:LOC100395489
uniprot id: A0A8I3WPU1
names: Similarity
messages: Belongs to the pro/parathymosin family.

9483:SLC25A14
gene id: 9483:SLC25A14
uniprot id: A0A2R8PEX3
uniprot id: A0A8I4A3E5
uniprot id: U3CVS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:CYB5R3
gene id: 9483:CYB5R3
uniprot id: U3C856
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9483:SAP18
gene id: 9483:SAP18
uniprot id: F7IS86
names: Similarity
messages: Belongs to the SAP18 family.

9483:CLDN1
gene id: 9483:CLDN1
uniprot id: U3BKB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9483:LOC100386428
gene id: 9483:LOC100386428
uniprot id: A0A5F4WEM7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9483:TBX18
gene id: 9483:TBX18
uniprot id: A0A2R8MFR8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:DCK
gene id: 9483:DCK
uniprot id: U3DGS6
names: Similarity
messages: Belongs to the DCK/DGK family.

9483:EDN1
gene id: 9483:EDN1
uniprot id: F7H803
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9483:TBX10
gene id: 9483:TBX10
uniprot id: U3EAC5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9483:NFIB
gene id: 9483:NFIB
uniprot id: A0A2R8MJS4
uniprot id: F6XMK2
uniprot id: F6YSB0
uniprot id: F6Z9T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9483:CDC42BPA
gene id: 9483:CDC42BPA
uniprot id: A0A2R8MXL9
uniprot id: F6WI88
uniprot id: F7G3D2
uniprot id: F7G3G2
uniprot id: U3EZV2
uniprot id: U3F4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

9483:SHKBP1
gene id: 9483:SHKBP1
uniprot id: F7G6M1
names: Similarity
messages: Belongs to the KCTD3 family.

9483:NODAL
gene id: 9483:NODAL
uniprot id: F7I2K8
names: Similarity
messages: Belongs to the TGF-beta family.

9483:REEP5
gene id: 9483:REEP5
uniprot id: U3FI78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9483:PIPOX
gene id: 9483:PIPOX
uniprot id: F7GSN9
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9483:EMX2
gene id: 9483:EMX2
uniprot id: F7E5H5
names: Subcellular Location Annotation
messages: Nucleus

9483:LOC100406483
gene id: 9483:LOC100406483
uniprot id: U3CIR1
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

9483:MPPED1
gene id: 9483:MPPED1
uniprot id: U3DH11
names: Similarity
messages: Belongs to the UPF0046 family.

9483:GNB5
gene id: 9483:GNB5
uniprot id: A0A2R8PDI1
uniprot id: U3D678
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9483:PLP2
gene id: 9483:PLP2
uniprot id: F6WQM2
names: Subcellular Location Annotation
messages: Membrane

9483:NDRG2
gene id: 9483:NDRG2
uniprot id: F7IH23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm
messages: growth cone

9483:TACR1
gene id: 9483:TACR1
uniprot id: F7HYI8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

9483:FIGN
gene id: 9483:FIGN
uniprot id: A0A2R8MW17
names: Similarity
messages: Belongs to the AAA ATPase family.

9483:MANBA
gene id: 9483:MANBA
uniprot id: A0A5F4W139
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

9483:CSTF2
gene id: 9483:CSTF2
uniprot id: F7HWT7
uniprot id: F7HWU0
names: Subcellular Location Annotation
messages: Nucleus

9483:MAOA
gene id: 9483:MAOA
uniprot id: A0A7G0WW04
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9483:OPN5
gene id: 9483:OPN5
uniprot id: F6PHB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9483:PARP11
gene id: 9483:PARP11
uniprot id: F7IBI0
uniprot id: U3C7G5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:MTAP
gene id: 9483:MTAP
uniprot id: F7I6R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9483:FMOD
gene id: 9483:FMOD
uniprot id: F7H3T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

9483:BEX3
gene id: 9483:BEX3
uniprot id: F7H6N3
names: Similarity
messages: Belongs to the BEX family.

9483:NBN
gene id: 9483:NBN
uniprot id: U3EK58
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
messages: Component of the MRN complex.
messages: Nucleus
messages: telomere

9483:PENK
gene id: 9483:PENK
uniprot id: F6WU13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

9483:NPFFR2
gene id: 9483:NPFFR2
uniprot id: A0A2R8PG03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9483:BYSL
gene id: 9483:BYSL
uniprot id: F6XKE7
names: Similarity
messages: Belongs to the bystin family.

9483:SLC11A1
gene id: 9483:SLC11A1
uniprot id: F7GRK1
uniprot id: U3DZC5
names: Similarity
messages: Belongs to the NRAMP family.

9483:TIGD4
gene id: 9483:TIGD4
uniprot id: F7HQK9
names: Subcellular Location Annotation
messages: Nucleus

9483:XRCC5
gene id: 9483:XRCC5
uniprot id: U3E6P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

9483:VEPH1
gene id: 9483:VEPH1
uniprot id: U3B398
names: Similarity
messages: Belongs to the MELT/VEPH family.

9483:NCBP2
gene id: 9483:NCBP2
uniprot id: F7B893
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9483:LOC100414020
gene id: 9483:LOC100414020
uniprot id: A0A5F4W5M3
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

9483:B3GALT5
gene id: 9483:B3GALT5
uniprot id: F6YSH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:FOXA1
gene id: 9483:FOXA1
uniprot id: U3BW21
names: Subcellular Location Annotation
messages: Nucleus

9483:GUCY1B1
gene id: 9483:GUCY1B1
uniprot id: F7FFL1
uniprot id: U3FX94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9483:BMP6
gene id: 9483:BMP6
uniprot id: F7FSA8
names: Similarity
messages: Belongs to the TGF-beta family.

9483:TECRL
gene id: 9483:TECRL
uniprot id: A0A5F4W8X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9483:FSD1L
gene id: 9483:FSD1L
uniprot id: U3D2E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:SRP19
gene id: 9483:SRP19
uniprot id: F6V6L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9483:PPP3CB
gene id: 9483:PPP3CB
uniprot id: A0A2R8MN08
uniprot id: F7GI92
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9483:ARPIN
gene id: 9483:ARPIN
uniprot id: U3FN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arpin family.
messages: lamellipodium

9483:NRG1
gene id: 9483:NRG1
uniprot id: A0A2R8MUP3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:NIPAL3
gene id: 9483:NIPAL3
uniprot id: U3BY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9483:MFSD5
gene id: 9483:MFSD5
uniprot id: F6VV55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

9483:SENP1
gene id: 9483:SENP1
uniprot id: U3FPX9
names: Similarity
messages: Belongs to the peptidase C48 family.

9483:PTTG1
gene id: 9483:PTTG1
uniprot id: F7E3V6
uniprot id: U3FLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9483:CCT2
gene id: 9483:CCT2
uniprot id: A0A8I3WI23
uniprot id: U3FVV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9483:SLC25A18
gene id: 9483:SLC25A18
uniprot id: F7HL67
uniprot id: U3DR59
uniprot id: U3E4V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9483:TMEM192
gene id: 9483:TMEM192
uniprot id: A0A2R8MKT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9483:LOC100896017
gene id: 9483:LOC100896017
uniprot id: A0A5F4WIS5
names: Similarity
messages: Belongs to the LCE family.

9483:CDC37
gene id: 9483:CDC37
uniprot id: F7GXW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9483:LOC103787267
gene id: 9483:LOC103787267
uniprot id: B0KWA5
names: Similarity
messages: Belongs to the KHDC1 family.

9483:WDFY2
gene id: 9483:WDFY2
uniprot id: F6W2Z2
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9483:GPR20
gene id: 9483:GPR20
uniprot id: A0A2R8MTD5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:DTD2
gene id: 9483:DTD2
uniprot id: F7CPR7
names: Similarity
messages: Belongs to the DTD family.

9483:STOM
gene id: 9483:STOM
uniprot id: U3ER07
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9483:ALDH1L2
gene id: 9483:ALDH1L2
uniprot id: F7H088
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9483:NAP1L2
gene id: 9483:NAP1L2
uniprot id: U3D3N0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9483:VANGL2
gene id: 9483:VANGL2
uniprot id: U3BVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9483:PPP4R3A
gene id: 9483:PPP4R3A
uniprot id: A0A8I3WPJ3
uniprot id: F6SXR3
uniprot id: F6TIK1
names: Similarity
messages: Belongs to the SMEK family.

9483:C7H1orf174
gene id: 9483:C7H1orf174
uniprot id: F7I356
uniprot id: F7IPG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9483:ADGRL2
gene id: 9483:ADGRL2
uniprot id: A0A2R8NDL4
uniprot id: F7IMA1
uniprot id: U3DLQ9
uniprot id: U3FSP2
names: Subcellular Location Annotation
messages: Membrane

9483:ATXN3
gene id: 9483:ATXN3
uniprot id: F6SV02
names: Subcellular Location Annotation
messages: Nucleus

9483:BRAF
gene id: 9483:BRAF
uniprot id: A0A2R8P5G8
uniprot id: U3CMC6
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9483:PLAG1
gene id: 9483:PLAG1
uniprot id: F6UJ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

9483:INSM2
gene id: 9483:INSM2
uniprot id: F6QBD1
names: Subcellular Location Annotation
messages: Nucleus

9483:TOP2A
gene id: 9483:TOP2A
uniprot id: F6T9B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

9483:PACSIN1
gene id: 9483:PACSIN1
uniprot id: F7A7B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9483:SH3BGRL2
gene id: 9483:SH3BGRL2
uniprot id: F7DLV5
uniprot id: U3BEF5
names: Similarity
messages: Belongs to the SH3BGR family.

9483:ACOT13
gene id: 9483:ACOT13
uniprot id: F7IQA2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

9483:KLC2
gene id: 9483:KLC2
uniprot id: F6W0Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9483:MAP1LC3A
gene id: 9483:MAP1LC3A
uniprot id: F6QPF6
names: Similarity
messages: Belongs to the ATG8 family.

9483:GPR39
gene id: 9483:GPR39
uniprot id: U3DHX8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:CADM2
gene id: 9483:CADM2
uniprot id: A0A2R8MWI3
uniprot id: F6VPM5
uniprot id: U3CI28
names: Similarity
messages: Belongs to the nectin family.

9483:MINPP1
gene id: 9483:MINPP1
uniprot id: F7HI35
uniprot id: U3E199
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

9483:CLTRN
gene id: 9483:CLTRN
uniprot id: F7C8H8
names: Subcellular Location Annotation
messages: Membrane

9483:TULP4
gene id: 9483:TULP4
uniprot id: U3EY06
names: Similarity
messages: Belongs to the TUB family.

9483:D2HGDH
gene id: 9483:D2HGDH
uniprot id: F7F4Q6
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

9483:RFC5
gene id: 9483:RFC5
uniprot id: U3BST5
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9483:SHOC2
gene id: 9483:SHOC2
uniprot id: U3FUC2
names: Function
names: Similarity
messages: Belongs to the SHOC2 family.
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

9483:ATP1A3
gene id: 9483:ATP1A3
uniprot id: A0A8I4A1P0
uniprot id: F7DR43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

9483:FAIM2
gene id: 9483:FAIM2
uniprot id: F7GY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9483:TUBA4A
gene id: 9483:TUBA4A
uniprot id: F6RZ34
uniprot id: F7HZP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

9483:RGS8
gene id: 9483:RGS8
uniprot id: A0A8J8YQA6
uniprot id: U3ERK1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: dendrite

9483:INTS7
gene id: 9483:INTS7
uniprot id: U3AS40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

9483:FGF12
gene id: 9483:FGF12
uniprot id: A0A2R8NAI2
uniprot id: U3C9Y3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9483:EIF1AX
gene id: 9483:EIF1AX
uniprot id: U3BE20
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

9483:STXBP3
gene id: 9483:STXBP3
uniprot id: F6W7C3
uniprot id: U3D3M4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9483:FUT1
gene id: 9483:FUT1
uniprot id: U3E6W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens. H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a.
messages: Golgi stack membrane
messages: Membrane

9483:TOR1B
gene id: 9483:TOR1B
uniprot id: U3C1X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9483:TPM3
gene id: 9483:TPM3
uniprot id: A0A2R8MKU8
uniprot id: F7I9P7
uniprot id: F7IC14
uniprot id: U3DK87
uniprot id: U3EBA3
uniprot id: U3ELS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9483:HAO2
gene id: 9483:HAO2
uniprot id: F7AA83
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9483:SPOCK1
gene id: 9483:SPOCK1
uniprot id: F7I1V8
uniprot id: U3FWP7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:NTSR2
gene id: 9483:NTSR2
uniprot id: F6S1P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:ATP5F1D
gene id: 9483:ATP5F1D
uniprot id: U3ASV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9483:ETV1
gene id: 9483:ETV1
uniprot id: F7AFA4
uniprot id: U3BML6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9483:IL36RN
gene id: 9483:IL36RN
uniprot id: F6VYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9483:PARVA
gene id: 9483:PARVA
uniprot id: A0A2R8MVK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

9483:USP10
gene id: 9483:USP10
uniprot id: F6PHS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9483:ZC3H12B
gene id: 9483:ZC3H12B
uniprot id: F7INC7
names: Similarity
messages: Belongs to the ZC3H12 family.

9483:SND1
gene id: 9483:SND1
uniprot id: U3BQS3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9483:SPSB1
gene id: 9483:SPSB1
uniprot id: F6SE99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

9483:TRIM26
gene id: 9483:TRIM26
uniprot id: F7IQQ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:PROK2
gene id: 9483:PROK2
uniprot id: A0A2R8N9W0
uniprot id: A0A8I3WA50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9483:RHBDL1
gene id: 9483:RHBDL1
uniprot id: F6YAM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9483:EPN2
gene id: 9483:EPN2
uniprot id: F7IJ10
uniprot id: U3EEG2
uniprot id: U3FWH5
names: Similarity
messages: Belongs to the epsin family.

9483:GNGT1
gene id: 9483:GNGT1
uniprot id: F6WMN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9483:NEU1
gene id: 9483:NEU1
uniprot id: F6YMA5
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9483:PPFIBP2
gene id: 9483:PPFIBP2
uniprot id: A0A5F4W4S2
uniprot id: U3EQ27
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9483:MFSD8
gene id: 9483:MFSD8
uniprot id: F6V932
uniprot id: U3FT36
names: Subcellular Location Annotation
messages: Membrane

9483:SLC5A9
gene id: 9483:SLC5A9
uniprot id: F7GZA9
uniprot id: U3BD27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9483:DIP2B
gene id: 9483:DIP2B
uniprot id: F7H527
uniprot id: U3CSQ1
names: Similarity
messages: Belongs to the DIP2 family.

9483:FAM199X
gene id: 9483:FAM199X
uniprot id: F7GPT7
names: Similarity
messages: Belongs to the FAM199 family.

9483:SLC39A9
gene id: 9483:SLC39A9
uniprot id: U3DR82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

9483:ANAPC15
gene id: 9483:ANAPC15
uniprot id: U3C3A1
uniprot id: U3EFC7
names: Similarity
messages: Belongs to the APC15 family.

9483:INSIG2
gene id: 9483:INSIG2
uniprot id: A0A5F4VWK9
uniprot id: B0CMA4
uniprot id: U3CHF3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); association is mediated via its interaction with SCAP and only takes place in the presence of sterols. Interacts with RNF139. Interacts with RNF145.
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane
messages: Oxidized at Cys-215 in differentiated myotubes, preventing ubiquitination at the same site, and resulting in protein stabilization.
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139.
messages: Phosphorylation at Ser-151 by PCK1 reduces binding to oxysterol, disrupting the interaction between INSIG2 and SCAP, thereby promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes.
messages: Polyubiquitinated by AMFR/gp78 at Cys-215 in some tissues such as adipose tissues, undifferentiated myoblasts and liver, leading to its degradation. In differentiated myotubes, Cys-215 oxidation prevents ubiquitination at the same site, resulting in protein stabilization.
messages: The KxHxx motif mediates association with the coatomer complex.

9483:DRAM2
gene id: 9483:DRAM2
uniprot id: F7GN83
names: Subcellular Location Annotation
messages: Membrane

9483:CATSPERE
gene id: 9483:CATSPERE
uniprot id: F7HLX8
names: Similarity
messages: Belongs to the CATSPERD family.

9483:LONP1
gene id: 9483:LONP1
uniprot id: F7IRU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer. Organized in a ring with a central cavity. The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG.
messages: Mitochondrion matrix

9483:CMPK2
gene id: 9483:CMPK2
uniprot id: A0A8I3WJ17
names: Similarity
messages: Belongs to the thymidylate kinase family.

9483:GJB1
gene id: 9483:GJB1
uniprot id: F6RE67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9483:KIAA1191
gene id: 9483:KIAA1191
uniprot id: F7HYZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9483:CDK6
gene id: 9483:CDK6
uniprot id: F6YF92
names: Similarity
messages: Belongs to the protein kinase superfamily.

9483:ZDHHC3
gene id: 9483:ZDHHC3
uniprot id: U3EX79
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9483:MTERF2
gene id: 9483:MTERF2
uniprot id: U3BJA2
names: Similarity
messages: Belongs to the mTERF family.

9483:NSUN4
gene id: 9483:NSUN4
uniprot id: F7HD16
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9483:ANAPC16
gene id: 9483:ANAPC16
uniprot id: F6X634
uniprot id: U3CQN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9483:SLC30A4
gene id: 9483:SLC30A4
uniprot id: F7EZU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9483:TMCC3
gene id: 9483:TMCC3
uniprot id: F7ICJ2
names: Similarity
messages: Belongs to the TEX28 family.

9483:INSIG1
gene id: 9483:INSIG1
uniprot id: A0A2R8P5G3
uniprot id: F6XME3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9483:EML4
gene id: 9483:EML4
uniprot id: F7E9Y2
uniprot id: F7GPN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

9483:TES
gene id: 9483:TES
uniprot id: Q2QLG8
uniprot id: U3BT74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

9483:YPEL3
gene id: 9483:YPEL3
uniprot id: A0A2R8MGE5
names: Similarity
messages: Belongs to the yippee family.

9483:IKBKB
gene id: 9483:IKBKB
uniprot id: F7IBM5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:MAFB
gene id: 9483:MAFB
uniprot id: U3EBS2
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

9483:SLC17A4
gene id: 9483:SLC17A4
uniprot id: F6YQZ5
names: Subcellular Location Annotation
messages: Membrane

9483:KRT24
gene id: 9483:KRT24
uniprot id: F6YJR0
names: Similarity
messages: Belongs to the intermediate filament family.

9483:UCN2
gene id: 9483:UCN2
uniprot id: F7ITE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9483:PELI2
gene id: 9483:PELI2
uniprot id: U3E794
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9483:LOC100394162
gene id: 9483:LOC100394162
uniprot id: F6RZ51
names: Similarity
messages: Belongs to the intermediate filament family.

9483:STK11IP
gene id: 9483:STK11IP
uniprot id: B0KWJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STK11IP family.
messages: Cytoplasm

9483:MB21D2
gene id: 9483:MB21D2
uniprot id: F7HXU5
names: Similarity
messages: Belongs to the mab-21 family.

9483:MAP6
gene id: 9483:MAP6
uniprot id: F6UHV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

9483:CPNE9
gene id: 9483:CPNE9
uniprot id: F7I7P4
names: Similarity
messages: Belongs to the copine family.

9483:ING2
gene id: 9483:ING2
uniprot id: F6V9W3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9483:ELMO1
gene id: 9483:ELMO1
uniprot id: F7IAL7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9483:CHI3L1
gene id: 9483:CHI3L1
uniprot id: F7GBD4
uniprot id: U3EQS4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Monomer.
messages: extracellular space

9483:GPR33
gene id: 9483:GPR33
uniprot id: A0A5F4VXG8
names: Subcellular Location Annotation
messages: Cell membrane

9483:PCOLCE
gene id: 9483:PCOLCE
uniprot id: F6WB30
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:MPDU1
gene id: 9483:MPDU1
uniprot id: F7GNS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9483:ARRDC3
gene id: 9483:ARRDC3
uniprot id: A0A2R8MNN7
names: Similarity
messages: Belongs to the arrestin family.

9483:LOC100397482
gene id: 9483:LOC100397482
uniprot id: U3CM30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:PARD6B
gene id: 9483:PARD6B
uniprot id: F6RQ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

9483:CORIN
gene id: 9483:CORIN
uniprot id: A0A2R8P1C2
uniprot id: F7HP67
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SPA17
gene id: 9483:SPA17
uniprot id: F7IN74
uniprot id: Q9XT29
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

9483:SLCO3A1
gene id: 9483:SLCO3A1
uniprot id: F7IEX0
uniprot id: U3DDR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9483:MID2
gene id: 9483:MID2
uniprot id: U3B1I8
uniprot id: U3EWX9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Nucleus
messages: cytoskeleton

9483:PSMG1
gene id: 9483:PSMG1
uniprot id: B0KW86
uniprot id: U3C6S6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity).
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Degraded by the proteasome upon completion of 20S proteasome maturation.
messages: Endoplasmic reticulum
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits (By similarity).
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9483:CPNE2
gene id: 9483:CPNE2
uniprot id: F7IQ37
uniprot id: U3FSA6
names: Similarity
messages: Belongs to the copine family.

9483:SGSM2
gene id: 9483:SGSM2
uniprot id: U3E5Y2
names: Similarity
messages: Belongs to the RUTBC family.

9483:LTV1
gene id: 9483:LTV1
uniprot id: F7H7Q1
names: Similarity
messages: Belongs to the LTV1 family.

9483:KPNA6
gene id: 9483:KPNA6
uniprot id: F7FPD9
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9483:KIF3B
gene id: 9483:KIF3B
uniprot id: F7IBN6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9483:SLC15A2
gene id: 9483:SLC15A2
uniprot id: F6YUC3
uniprot id: F7CVE6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9483:KIAA1958
gene id: 9483:KIAA1958
uniprot id: F7HGL2
names: Similarity
messages: Belongs to the sorting nexin family.

9483:SYNPR
gene id: 9483:SYNPR
uniprot id: A0A2R8MVD5
uniprot id: U3EN47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9483:ADGRG6
gene id: 9483:ADGRG6
uniprot id: A0A8I3WLK5
uniprot id: F6QI92
uniprot id: F7IP60
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:SLC39A12
gene id: 9483:SLC39A12
uniprot id: A0A8I3WPZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9483:NOL6
gene id: 9483:NOL6
uniprot id: U3FMY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

9483:TRIM44
gene id: 9483:TRIM44
uniprot id: A0A8I3WIK4
uniprot id: F7H6Y0
names: Subcellular Location Annotation
messages: Cytoplasm

9483:ALDH1A2
gene id: 9483:ALDH1A2
uniprot id: U3DC38
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9483:LOC100402677
gene id: 9483:LOC100402677
uniprot id: A0A2R8N908
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9483:EXOC8
gene id: 9483:EXOC8
uniprot id: U3AW65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

9483:CALHM6
gene id: 9483:CALHM6
uniprot id: F7IPY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9483:SGCE
gene id: 9483:SGCE
uniprot id: A0A5K1U701
uniprot id: F6SLC1
uniprot id: U3D1I1
uniprot id: U3ET27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Golgi apparatus
messages: cytoskeleton
messages: dendrite
messages: sarcolemma

9483:GAD2
gene id: 9483:GAD2
uniprot id: F7I4W5
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9483:TNFSF13
gene id: 9483:TNFSF13
uniprot id: A0A2R8MGF4
uniprot id: F7GHR8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9483:PRPF38A
gene id: 9483:PRPF38A
uniprot id: U3FEZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9483:MRPL12
gene id: 9483:MRPL12
uniprot id: F7HX78
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

9483:CHN1
gene id: 9483:CHN1
uniprot id: A0A5F4WBW9
uniprot id: U3FJE7
names: Function
messages: GTPase-activating protein for p21-rac.

9483:YJU2
gene id: 9483:YJU2
uniprot id: U3DXX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

9483:PHB
gene id: 9483:PHB
uniprot id: F7AH92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

9483:C7
gene id: 9483:C7
uniprot id: U3BDC8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9483:ADCYAP1
gene id: 9483:ADCYAP1
uniprot id: U3CGG8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucagon family.
messages: Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
messages: Secreted

9483:SIX5
gene id: 9483:SIX5
uniprot id: F7HN42
names: Subcellular Location Annotation
messages: Nucleus

9483:SLC46A3
gene id: 9483:SLC46A3
uniprot id: F7H3K0
names: Subcellular Location Annotation
messages: Membrane

9483:ACOD1
gene id: 9483:ACOD1
uniprot id: F7FT06
names: Similarity
messages: Belongs to the PrpD family.

9483:PAPSS1
gene id: 9483:PAPSS1
uniprot id: A0A2R8MBW0
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9483:GMDS
gene id: 9483:GMDS
uniprot id: A0A2R8PJ06
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9483:SLC41A1
gene id: 9483:SLC41A1
uniprot id: F7FY35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9483:LOC100894903
gene id: 9483:LOC100894903
uniprot id: A0A8I3WMT9
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9483:SMDT1
gene id: 9483:SMDT1
uniprot id: H9KVS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9483:RGS14
gene id: 9483:RGS14
uniprot id: U3BVC0
names: Subcellular Location Annotation
messages: dendrite

9483:GFM2
gene id: 9483:GFM2
uniprot id: U3D1H4
uniprot id: U3F9Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9483:NAPG
gene id: 9483:NAPG
uniprot id: U3D967
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9483:TK2
gene id: 9483:TK2
uniprot id: U3C684
names: Similarity
messages: Belongs to the DCK/DGK family.

9483:ADRB3
gene id: 9483:ADRB3
uniprot id: F6XZF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.
messages: Membrane

9483:LEPROT
gene id: 9483:LEPROT
uniprot id: A0A5F4VXX7
uniprot id: F7IAD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9483:MTHFR
gene id: 9483:MTHFR
uniprot id: F7HIS1
uniprot id: U3CLG5
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9483:RNF146
gene id: 9483:RNF146
uniprot id: F7HB59
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9483:MIDN
gene id: 9483:MIDN
uniprot id: A0A2R8P8Z5
names: Subcellular Location Annotation
messages: Nucleus

9483:CYP1A2
gene id: 9483:CYP1A2
uniprot id: O77810
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.
messages: Microsome membrane

9483:MAP3K5
gene id: 9483:MAP3K5
uniprot id: U3DSH8
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9483:SPPL3
gene id: 9483:SPPL3
uniprot id: A0A8I3WAH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9483:SOD2
gene id: 9483:SOD2
uniprot id: Q8HXP0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-98 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
messages: Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.

9483:RFTN2
gene id: 9483:RFTN2
uniprot id: F6PHM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9483:MEP1B
gene id: 9483:MEP1B
uniprot id: F7I1Y3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:GOLPH3
gene id: 9483:GOLPH3
uniprot id: F7I3I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9483:APOO
gene id: 9483:APOO
uniprot id: F7I3C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9483:ADCY9
gene id: 9483:ADCY9
uniprot id: F6RS83
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9483:TP53I11
gene id: 9483:TP53I11
uniprot id: U3CZ55
names: Subcellular Location Annotation
messages: Membrane

9483:RWDD3
gene id: 9483:RWDD3
uniprot id: F6SIH3
uniprot id: U3E9M5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9483:GDAP1L1
gene id: 9483:GDAP1L1
uniprot id: U3CTE0
names: Similarity
messages: Belongs to the GST superfamily.

9483:KCNH8
gene id: 9483:KCNH8
uniprot id: F7F3H8
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9483:USP49
gene id: 9483:USP49
uniprot id: B0KWN4
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:REEP3
gene id: 9483:REEP3
uniprot id: F6ZYR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9483:ACTR1A
gene id: 9483:ACTR1A
uniprot id: F6XCG8
uniprot id: U3CBW6
names: Similarity
messages: Belongs to the actin family.

9483:CLCN6
gene id: 9483:CLCN6
uniprot id: F6YJI7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:RRP8
gene id: 9483:RRP8
uniprot id: U3F2N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Component of the eNoSC complex.
messages: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.
messages: nucleolus

9483:CCBE1
gene id: 9483:CCBE1
uniprot id: F7GK04
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MGAT4C
gene id: 9483:MGAT4C
uniprot id: F6RTS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:CRYBA2
gene id: 9483:CRYBA2
uniprot id: F6QHI7
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9483:AQP4
gene id: 9483:AQP4
uniprot id: F7I6W3
uniprot id: F7I6X5
uniprot id: U3E3H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9483:SGCG
gene id: 9483:SGCG
uniprot id: F7HWH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9483:INA
gene id: 9483:INA
uniprot id: F6QYT4
names: Similarity
messages: Belongs to the intermediate filament family.

9483:IMPG1
gene id: 9483:IMPG1
uniprot id: A0A2R8PEX5
uniprot id: F6SRM0
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

9483:HMGN4
gene id: 9483:HMGN4
uniprot id: F7G9N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9483:RBBP4
gene id: 9483:RBBP4
uniprot id: U3BF00
names: Subcellular Location Annotation
messages: Nucleus

9483:SEPTIN12
gene id: 9483:SEPTIN12
uniprot id: F6PWH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9483:TTYH2
gene id: 9483:TTYH2
uniprot id: F7GUD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9483:PARP6
gene id: 9483:PARP6
uniprot id: U3E0E5
names: Similarity
messages: Belongs to the ARTD/PARP family.

9483:PLPPR2
gene id: 9483:PLPPR2
uniprot id: F7IFL6
uniprot id: U3EB96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9483:GADD45A
gene id: 9483:GADD45A
uniprot id: A0A8I3WE50
uniprot id: F7E1K0
names: Similarity
messages: Belongs to the GADD45 family.

9483:DTNA
gene id: 9483:DTNA
uniprot id: A0A2R8M781
uniprot id: A0A5K1VRY8
uniprot id: F7ENB9
uniprot id: F7ENC8
uniprot id: F7ENP0
uniprot id: F7F217
uniprot id: F7F228
uniprot id: F7FUS1
uniprot id: U3E450
uniprot id: U3F338
uniprot id: U3FJ85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9483:TRIP10
gene id: 9483:TRIP10
uniprot id: F7BSL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Lysosome
messages: Membrane
messages: cell cortex

9483:POU4F2
gene id: 9483:POU4F2
uniprot id: F6W7V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9483:LYZ
gene id: 9483:LYZ
uniprot id: P79158
uniprot id: U3FDD0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
messages: Monomer.

9483:YWHAQ
gene id: 9483:YWHAQ
uniprot id: F7DMM3
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
messages: Belongs to the 14-3-3 family.

9483:LOXL2
gene id: 9483:LOXL2
uniprot id: U3D6J6
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9483:SH3YL1
gene id: 9483:SH3YL1
uniprot id: A0A5K1TUW4
uniprot id: F6RB94
uniprot id: U3AVX4
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9483:TACO1
gene id: 9483:TACO1
uniprot id: U3FFC6
names: Similarity
messages: Belongs to the TACO1 family.

9483:PSMB1
gene id: 9483:PSMB1
uniprot id: U3DT66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:USP44
gene id: 9483:USP44
uniprot id: F7CHC5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9483:CSNK1G1
gene id: 9483:CSNK1G1
uniprot id: A0A2R8MI70
uniprot id: A0A2R8MT47
uniprot id: F7I3V3
uniprot id: U3DAC9
uniprot id: U3EF14
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9483:DLL1
gene id: 9483:DLL1
uniprot id: F7HV65
uniprot id: U3F3S0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9483:LOC100407306
gene id: 9483:LOC100407306
uniprot id: F7IHF9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

9483:MFSD4A
gene id: 9483:MFSD4A
uniprot id: U3B6V7
names: Subcellular Location Annotation
messages: Membrane

9483:CERS5
gene id: 9483:CERS5
uniprot id: F7F1C1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9483:LOC103789858
gene id: 9483:LOC103789858
uniprot id: A0A5F4WFE7
names: Similarity
messages: Belongs to the STEEP1 family.

9483:FNTB
gene id: 9483:FNTB
uniprot id: U3FQ12
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9483:TRIM41
gene id: 9483:TRIM41
uniprot id: F7HTG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70. Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3. Interacts with SQSTM1. Interacts with TRIM6 and TRIM34. Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1.
messages: Cytoplasm
messages: Nucleus

9483:LOC100409289
gene id: 9483:LOC100409289
uniprot id: A0A8I3ZZM3
names: Similarity
messages: Belongs to the NAC-beta family.

9483:CHST9
gene id: 9483:CHST9
uniprot id: F7CJ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9483:ERCC3
gene id: 9483:ERCC3
uniprot id: U3CZS4
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9483:CACUL1
gene id: 9483:CACUL1
uniprot id: F7GMU9
names: Similarity
messages: Belongs to the cullin family.

9483:UBL3
gene id: 9483:UBL3
uniprot id: F6YU90
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9483:LRRC42
gene id: 9483:LRRC42
uniprot id: F7IF62
uniprot id: F7IMX3
names: Similarity
messages: Belongs to the LRRC42 family.

9483:DRD1
gene id: 9483:DRD1
uniprot id: F7GPB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
messages: Membrane
messages: dendritic spine

9483:LOC100413757
gene id: 9483:LOC100413757
uniprot id: F7DXF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

9483:NFE2L1
gene id: 9483:NFE2L1
uniprot id: F7I074
uniprot id: U3FVE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. CNC subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9483:OVOL1
gene id: 9483:OVOL1
uniprot id: F7F0J6
names: Subcellular Location Annotation
messages: Nucleus

9483:SEMA3D
gene id: 9483:SEMA3D
uniprot id: F7D0I7
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:MMAA
gene id: 9483:MMAA
uniprot id: F6YMK1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

9483:C16H8orf33
gene id: 9483:C16H8orf33
uniprot id: U3DG87
names: Similarity
messages: Belongs to the UPF0488 family.

9483:TMEM267
gene id: 9483:TMEM267
uniprot id: U3FKE8
names: Subcellular Location Annotation
messages: Membrane

9483:SLC16A4
gene id: 9483:SLC16A4
uniprot id: U3EYR4
uniprot id: U3FXK0
names: Subcellular Location Annotation
messages: Membrane

9483:DLGAP3
gene id: 9483:DLGAP3
uniprot id: U3DMW4
names: Similarity
messages: Belongs to the SAPAP family.

9483:LOXL1
gene id: 9483:LOXL1
uniprot id: F6S0D4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9483:FAM149B1
gene id: 9483:FAM149B1
uniprot id: F7HP81
names: Similarity
messages: Belongs to the FAM149 family.

9483:SMC1B
gene id: 9483:SMC1B
uniprot id: F6RQV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9483:FBXO31
gene id: 9483:FBXO31
uniprot id: U3E6U3
names: Similarity
names: Subunit
messages: Belongs to the FBXO31 family.
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

9483:GAS6
gene id: 9483:GAS6
uniprot id: U3EZ84
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9483:SLC37A4
gene id: 9483:SLC37A4
uniprot id: F6VHY7
uniprot id: U3DRQ5
uniprot id: U3E234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9483:HCAR1
gene id: 9483:HCAR1
uniprot id: A0A5F4WJ68
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9483:C16H8orf37
gene id: 9483:C16H8orf37
uniprot id: A0A2R8MZL3
uniprot id: F7I023
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9483:ADGRF4
gene id: 9483:ADGRF4
uniprot id: F6TPG4
names: Subcellular Location Annotation
messages: Membrane

9483:FZR1
gene id: 9483:FZR1
uniprot id: F7GUM2
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9483:PRPF4
gene id: 9483:PRPF4
uniprot id: U3C117
names: Subcellular Location Annotation
messages: Nucleus speckle

9483:RCL1
gene id: 9483:RCL1
uniprot id: A0A2R8MWA1
uniprot id: U3FH01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

9483:PSMB10
gene id: 9483:PSMB10
uniprot id: U3DF12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9483:PLXNB1
gene id: 9483:PLXNB1
uniprot id: F7IAA7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9483:CCDC172
gene id: 9483:CCDC172
uniprot id: F7GTK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

9483:COX6B2
gene id: 9483:COX6B2
uniprot id: A0A8I3WWF5
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9483:IL5
gene id: 9483:IL5
uniprot id: Q0Z974
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9483:FAM131A
gene id: 9483:FAM131A
uniprot id: F7H4H4
names: Similarity
messages: Belongs to the FAM131 family.

9483:CLNS1A
gene id: 9483:CLNS1A
uniprot id: A0A2R8MJB4
uniprot id: U3FEP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9483:GH1
gene id: 9483:GH1
uniprot id: A0AAU6
uniprot id: Q9GMB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity).
messages: Secreted

9483:PPP3R1
gene id: 9483:PPP3R1
uniprot id: F7GNF2
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9483:CDC26
gene id: 9483:CDC26
uniprot id: F7GVM0
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9483:IDH3A
gene id: 9483:IDH3A
uniprot id: U3E4Q8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9483:PHYHIPL
gene id: 9483:PHYHIPL
uniprot id: A0A2R8MLX1
names: Similarity
messages: Belongs to the PHYHIP family.

9483:GLO1
gene id: 9483:GLO1
uniprot id: F7II04
uniprot id: U3CM58
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9483:ARAF
gene id: 9483:ARAF
uniprot id: A0A5K1VS71
uniprot id: U3ETY3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9483:LOC100386289
gene id: 9483:LOC100386289
uniprot id: A0A2R8P0B6
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9483:FAM53A
gene id: 9483:FAM53A
uniprot id: U3DKY1
names: Similarity
messages: Belongs to the FAM53 family.

9483:LOC100402206
gene id: 9483:LOC100402206
uniprot id: A0A2R8PKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9483:CXXC1
gene id: 9483:CXXC1
uniprot id: U3D9T3
uniprot id: U3DLM1
names: Subcellular Location Annotation
messages: Nucleus