940295:EYM RS06915
gene id: 940295:EYM_RS06915
uniprot id: A0A0U3E9M8
names: Similarity
messages: Belongs to the glutaredoxin family.

940295:EYM RS03365
gene id: 940295:EYM_RS03365
uniprot id: A0A0U2M9H3
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

940295:EYM RS06855
gene id: 940295:EYM_RS06855
uniprot id: A0A0U3FJG8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

940295:EYM RS01980
gene id: 940295:EYM_RS01980
uniprot id: A0A0U3FNH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

940295:EYM RS02965
gene id: 940295:EYM_RS02965
uniprot id: A0A0U2WN64
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

940295:EYM RS07285
gene id: 940295:EYM_RS07285
uniprot id: A0A0U2U7F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

940295:EYM RS05965
gene id: 940295:EYM_RS05965
uniprot id: A0A0U3G0S1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS00220
gene id: 940295:EYM_RS00220
uniprot id: A0A0U3DVA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

940295:EYM RS04035
gene id: 940295:EYM_RS04035
uniprot id: A0A0U3F901
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

940295:EYM RS07620
gene id: 940295:EYM_RS07620
uniprot id: A0A0U3E9U2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

940295:EYM RS02465
gene id: 940295:EYM_RS02465
uniprot id: A0A0U2M9B5
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

940295:EYM RS00240
gene id: 940295:EYM_RS00240
uniprot id: A0A0U2M8X9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

940295:EYM RS04815
gene id: 940295:EYM_RS04815
uniprot id: A0A0U3FIU1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

940295:EYM RS07665
gene id: 940295:EYM_RS07665
uniprot id: A0A0U2VDF4
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

940295:EYM RS07650
gene id: 940295:EYM_RS07650
uniprot id: A0A0U3G3S1
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

940295:EYM RS00580
gene id: 940295:EYM_RS00580
uniprot id: A0A0U3DVF0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

940295:EYM RS06375
gene id: 940295:EYM_RS06375
uniprot id: A0A0U3F350
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

940295:EYM RS01595
gene id: 940295:EYM_RS01595
uniprot id: A0A0U3F789
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

940295:EYM RS01875
gene id: 940295:EYM_RS01875
uniprot id: A0A0U2M979
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS00495
gene id: 940295:EYM_RS00495
uniprot id: A0A0U3E7N3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

940295:EYM RS02700
gene id: 940295:EYM_RS02700
uniprot id: A0A0U3F203
names: Similarity
messages: Belongs to the HypD family.

940295:EYM RS04520
gene id: 940295:EYM_RS04520
uniprot id: A0A0U3FP86
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

940295:EYM RS02410
gene id: 940295:EYM_RS02410
uniprot id: A0A0U3F7E9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

940295:EYM RS02875
gene id: 940295:EYM_RS02875
uniprot id: A0A0U3FI84
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

940295:EYM RS02335
gene id: 940295:EYM_RS02335
uniprot id: A0A0U2U8B0
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

940295:EYM RS05175
gene id: 940295:EYM_RS05175
uniprot id: A0A0U2U6R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

940295:EYM RS01785
gene id: 940295:EYM_RS01785
uniprot id: A0A0U2VDY8
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS06160
gene id: 940295:EYM_RS06160
uniprot id: A0A0U2M9Z8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

940295:EYM RS00290
gene id: 940295:EYM_RS00290
uniprot id: A0A0U3F1D2
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

940295:EYM RS01450
gene id: 940295:EYM_RS01450
uniprot id: A0A0U3FZG4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

940295:EYM RS05970
gene id: 940295:EYM_RS05970
uniprot id: A0A0U2M9Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

940295:EYM RS03455
gene id: 940295:EYM_RS03455
uniprot id: A0A0U3FNX2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

940295:EYM RS07165
gene id: 940295:EYM_RS07165
uniprot id: A0A0U2U7D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

940295:EYM RS03400
gene id: 940295:EYM_RS03400
uniprot id: A0A0U2VC36
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

940295:EYM RS00370
gene id: 940295:EYM_RS00370
uniprot id: A0A0U3FPJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

940295:EYM RS04720
gene id: 940295:EYM_RS04720
uniprot id: A0A0U3FSQ1
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

940295:EYM RS03485
gene id: 940295:EYM_RS03485
uniprot id: A0A0U3E180
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

940295:EYM RS00695
gene id: 940295:EYM_RS00695
uniprot id: A0A0U3EAG3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS06460
gene id: 940295:EYM_RS06460
uniprot id: A0A0U3F9L5
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS05995
gene id: 940295:EYM_RS05995
uniprot id: A0A0U3F9E5
names: Similarity
messages: Belongs to the diphthine synthase family.

940295:EYM RS04510
gene id: 940295:EYM_RS04510
uniprot id: A0A0U3F2N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

940295:EYM RS00365
gene id: 940295:EYM_RS00365
uniprot id: A0A0U3FLW8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

940295:EYM RS05275
gene id: 940295:EYM_RS05275
uniprot id: A0A0U3E941
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

940295:EYM RS00020
gene id: 940295:EYM_RS00020
uniprot id: A0A0U3FQA6
names: Subcellular Location Annotation
messages: Nucleus

940295:EYM RS05870
gene id: 940295:EYM_RS05870
uniprot id: A0A0U3E407
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS04275
gene id: 940295:EYM_RS04275
uniprot id: A0A0U3G0A4
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

940295:EYM RS05495
gene id: 940295:EYM_RS05495
uniprot id: A0A0U3EBN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

940295:EYM RS06835
gene id: 940295:EYM_RS06835
uniprot id: A0A0U2VD53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

940295:EYM RS01150
gene id: 940295:EYM_RS01150
uniprot id: A0A0U2M935
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

940295:EYM RS07585
gene id: 940295:EYM_RS07585
uniprot id: A0A0U3DX44
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS00500
gene id: 940295:EYM_RS00500
uniprot id: A0A0U3FLY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

940295:EYM RS05190
gene id: 940295:EYM_RS05190
uniprot id: A0A0U3FPJ6
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

940295:EYM RS05290
gene id: 940295:EYM_RS05290
uniprot id: A0A0U3FQW7
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

940295:EYM RS04810
gene id: 940295:EYM_RS04810
uniprot id: A0A0U3F2Q9
names: Function
messages: Probably involved in the biogenesis of the ribosome.

940295:EYM RS05425
gene id: 940295:EYM_RS05425
uniprot id: A0A0U3FNG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

940295:EYM RS02420
gene id: 940295:EYM_RS02420
uniprot id: A0A0U3DVU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

940295:EYM RS06360
gene id: 940295:EYM_RS06360
uniprot id: A0A0U2VD02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

940295:EYM RS02540
gene id: 940295:EYM_RS02540
uniprot id: A0A0U3FR02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

940295:EYM RS06185
gene id: 940295:EYM_RS06185
uniprot id: A0A0U2VCY5
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

940295:EYM RS00245
gene id: 940295:EYM_RS00245
uniprot id: A0A0U3E7K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

940295:EYM RS04445
gene id: 940295:EYM_RS04445
uniprot id: A0A0U3E8T8
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

940295:EYM RS03225
gene id: 940295:EYM_RS03225
uniprot id: A0A0U2WL30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

940295:EYM RS00540
gene id: 940295:EYM_RS00540
uniprot id: A0A0U3F1H1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

940295:EYM RS05695
gene id: 940295:EYM_RS05695
uniprot id: A0A0U3FJ33
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

940295:EYM RS06690
gene id: 940295:EYM_RS06690
uniprot id: A0A0U2VFG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

940295:EYM RS04150
gene id: 940295:EYM_RS04150
uniprot id: A0A0U2M9M5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

940295:EYM RS04950
gene id: 940295:EYM_RS04950
uniprot id: A0A0U3FQT5
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

940295:EYM RS04050
gene id: 940295:EYM_RS04050
uniprot id: A0A0U2WLB8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

940295:EYM RS04880
gene id: 940295:EYM_RS04880
uniprot id: A0A0U2U8Z3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

940295:EYM RS02695
gene id: 940295:EYM_RS02695
uniprot id: A0A0U2U603
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

940295:EYM RS07155
gene id: 940295:EYM_RS07155
uniprot id: A0A0U3EC44
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

940295:EYM RS03300
gene id: 940295:EYM_RS03300
uniprot id: A0A0U3F7P1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

940295:EYM RS01655
gene id: 940295:EYM_RS01655
uniprot id: A0A0U3E7Z7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

940295:EYM RS00755
gene id: 940295:EYM_RS00755
uniprot id: A0A0U3G1D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

940295:EYM RS01880
gene id: 940295:EYM_RS01880
uniprot id: A0A0U3E822
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

940295:EYM RS00035
gene id: 940295:EYM_RS00035
uniprot id: A0A0U2VB14
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

940295:EYM RS03925
gene id: 940295:EYM_RS03925
uniprot id: A0A0U3FIJ5
names: Similarity
messages: Belongs to the peptidase C56 family.

940295:EYM RS02680
gene id: 940295:EYM_RS02680
uniprot id: A0A0U3F8N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

940295:EYM RS00040
gene id: 940295:EYM_RS00040
uniprot id: A0A0U3EA73
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

940295:EYM RS03630
gene id: 940295:EYM_RS03630
uniprot id: A0A0U3FNZ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

940295:EYM RS03820
gene id: 940295:EYM_RS03820
uniprot id: A0A0U3E1B2
names: Similarity
messages: Belongs to the UPF0179 family.

940295:EYM RS01520
gene id: 940295:EYM_RS01520
uniprot id: A0A0U2U5P3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

940295:EYM RS05135
gene id: 940295:EYM_RS05135
uniprot id: A0A0U2WLP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

940295:EYM RS02720
gene id: 940295:EYM_RS02720
uniprot id: A0A0U3F694
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

940295:EYM RS00570
gene id: 940295:EYM_RS00570
uniprot id: A0A0U3F6Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

940295:EYM RS00255
gene id: 940295:EYM_RS00255
uniprot id: A0A0U3FPH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

940295:EYM RS07490
gene id: 940295:EYM_RS07490
uniprot id: A0A0U2VDD7
names: Similarity
messages: Belongs to the HerA family.

940295:EYM RS02080
gene id: 940295:EYM_RS02080
uniprot id: A0A0U2U879
names: Similarity
messages: Belongs to the complex I subunit 3 family.

940295:EYM RS07605
gene id: 940295:EYM_RS07605
uniprot id: A0A0U3G185
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

940295:EYM RS02405
gene id: 940295:EYM_RS02405
uniprot id: A0A0U3F652
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

940295:EYM RS06945
gene id: 940295:EYM_RS06945
uniprot id: A0A0U2WM41
names: Function
names: Similarity
messages: Belongs to the TrpA family.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

940295:EYM RS05500
gene id: 940295:EYM_RS05500
uniprot id: A0A0U2VF52
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

940295:EYM RS06975
gene id: 940295:EYM_RS06975
uniprot id: A0A0U2VD71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

940295:EYM RS05725
gene id: 940295:EYM_RS05725
uniprot id: A0A0U3DWM6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

940295:EYM RS00160
gene id: 940295:EYM_RS00160
uniprot id: A0A0U2WMB4
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

940295:EYM RS00215
gene id: 940295:EYM_RS00215
uniprot id: A0A0U3F6U6
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

940295:EYM RS02850
gene id: 940295:EYM_RS02850
uniprot id: A0A0U3EAY0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

940295:EYM RS03520
gene id: 940295:EYM_RS03520
uniprot id: A0A0U2M9I5
names: Similarity
messages: Belongs to the AOR/FOR family.

940295:EYM RS02160
gene id: 940295:EYM_RS02160
uniprot id: A0A0U2VBR0
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

940295:EYM RS05910
gene id: 940295:EYM_RS05910
uniprot id: A0A0U3FQN7
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS00605
gene id: 940295:EYM_RS00605
uniprot id: A0A0U3FZ85
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

940295:EYM RS04220
gene id: 940295:EYM_RS04220
uniprot id: A0A0U3FIM8
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

940295:EYM RS07520
gene id: 940295:EYM_RS07520
uniprot id: A0A0U3EBV9
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS04740
gene id: 940295:EYM_RS04740
uniprot id: A0A0U2VEV3
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

940295:EYM RS04555
gene id: 940295:EYM_RS04555
uniprot id: A0A0U3E1I8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

940295:EYM RS00110
gene id: 940295:EYM_RS00110
uniprot id: A0A0U3E0A4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS07270
gene id: 940295:EYM_RS07270
uniprot id: A0A0U2WM59
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

940295:EYM RS04435
gene id: 940295:EYM_RS04435
uniprot id: A0A0U2M9P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

940295:EYM RS03415
gene id: 940295:EYM_RS03415
uniprot id: A0A0U3EB42
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

940295:EYM RS06850
gene id: 940295:EYM_RS06850
uniprot id: A0A0U3F394
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

940295:EYM RS07025
gene id: 940295:EYM_RS07025
uniprot id: A0A0U3F8R6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

940295:EYM RS06605
gene id: 940295:EYM_RS06605
uniprot id: A0A0U3G0Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

940295:EYM RS03980
gene id: 940295:EYM_RS03980
uniprot id: A0A0U3G078
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

940295:EYM RS03745
gene id: 940295:EYM_RS03745
uniprot id: A0A0U2U6B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

940295:EYM RS07140
gene id: 940295:EYM_RS07140
uniprot id: A0A0U2WM50
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

940295:EYM RS05855
gene id: 940295:EYM_RS05855
uniprot id: A0A0U2WLV3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

940295:EYM RS00015
gene id: 940295:EYM_RS00015
uniprot id: A0A0U3FLS9
names: Similarity
messages: Belongs to the MCM family.

940295:EYM RS00610
gene id: 940295:EYM_RS00610
uniprot id: A0A0U2MAB7
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS04135
gene id: 940295:EYM_RS04135
uniprot id: A0A0U3E1D8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

940295:EYM RS03975
gene id: 940295:EYM_RS03975
uniprot id: A0A0U3E1C1
names: Similarity
messages: Belongs to the DMRL synthase family.

940295:EYM RS02195
gene id: 940295:EYM_RS02195
uniprot id: A0A0U3F1V8
names: Similarity
messages: Belongs to the BtpA family.

940295:EYM RS06470
gene id: 940295:EYM_RS06470
uniprot id: A0A0U2MA16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

940295:EYM RS00520
gene id: 940295:EYM_RS00520
uniprot id: A0A0U2VBC3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

940295:EYM RS04200
gene id: 940295:EYM_RS04200
uniprot id: A0A0U2U6G1
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

940295:EYM RS00840
gene id: 940295:EYM_RS00840
uniprot id: A0A0U3FPN7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

940295:EYM RS04800
gene id: 940295:EYM_RS04800
uniprot id: A0A0U2U6N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

940295:EYM RS03000
gene id: 940295:EYM_RS03000
uniprot id: A0A0U3FI98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS06745
gene id: 940295:EYM_RS06745
uniprot id: A0A0U3FPX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

940295:EYM RS02370
gene id: 940295:EYM_RS02370
uniprot id: A0A0U2U5X1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

940295:EYM RS03170
gene id: 940295:EYM_RS03170
uniprot id: A0A0U3DW07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

940295:EYM RS00385
gene id: 940295:EYM_RS00385
uniprot id: A0A0U3EAB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

940295:EYM RS02085
gene id: 940295:EYM_RS02085
uniprot id: A0A0U3E846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

940295:EYM RS03285
gene id: 940295:EYM_RS03285
uniprot id: A0A0U3FKP5
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

940295:EYM RS04480
gene id: 940295:EYM_RS04480
uniprot id: A0A0U2U6J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

940295:EYM RS04070
gene id: 940295:EYM_RS04070
uniprot id: A0A0U3EBA4
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

940295:EYM RS00950
gene id: 940295:EYM_RS00950
uniprot id: A0A0U3DVH6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

940295:EYM RS02970
gene id: 940295:EYM_RS02970
uniprot id: A0A0U2VEE6
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

940295:EYM RS02395
gene id: 940295:EYM_RS02395
uniprot id: A0A0U3FI32
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

940295:EYM RS05585
gene id: 940295:EYM_RS05585
uniprot id: A0A0U3E1T6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

940295:EYM RS02650
gene id: 940295:EYM_RS02650
uniprot id: A0A0U3FMH9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

940295:EYM RS01305
gene id: 940295:EYM_RS01305
uniprot id: A0A0U3DVL3
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

940295:EYM RS02480
gene id: 940295:EYM_RS02480
uniprot id: A0A0U3FME1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

940295:EYM RS01770
gene id: 940295:EYM_RS01770
uniprot id: A0A0U3FPP1
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS05195
gene id: 940295:EYM_RS05195
uniprot id: A0A0U3F714
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

940295:EYM RS02350
gene id: 940295:EYM_RS02350
uniprot id: A0A0U3FKE1
names: Similarity
messages: Belongs to the UPF0166 family.

940295:EYM RS06600
gene id: 940295:EYM_RS06600
uniprot id: A0A0U3E230
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

940295:EYM RS07190
gene id: 940295:EYM_RS07190
uniprot id: A0A0U3F7M6
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

940295:EYM RS04110
gene id: 940295:EYM_RS04110
uniprot id: A0A0U3F7Y2
names: Similarity
messages: Belongs to the SAICAR synthetase family.

940295:EYM RS06480
gene id: 940295:EYM_RS06480
uniprot id: A0A0U3FAK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

940295:EYM RS01940
gene id: 940295:EYM_RS01940
uniprot id: A0A0U2VBP3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

940295:EYM RS07940
gene id: 940295:EYM_RS07940
uniprot id: A0A0U2VFP7
names: Similarity
messages: Belongs to the class-I fumarase family.

940295:EYM RS00030
gene id: 940295:EYM_RS00030
uniprot id: A0A0U2WK42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

940295:EYM RS07640
gene id: 940295:EYM_RS07640
uniprot id: A0A0U3E4H6
names: Similarity
messages: Belongs to the Ahb/Nir family.

940295:EYM RS03190
gene id: 940295:EYM_RS03190
uniprot id: A0A0U2M9G1
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

940295:EYM RS05330
gene id: 940295:EYM_RS05330
uniprot id: A0A0U3F2V2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS06595
gene id: 940295:EYM_RS06595
uniprot id: A0A0U3DWV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

940295:EYM RS03290
gene id: 940295:EYM_RS03290
uniprot id: A0A0U3F6G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

940295:EYM RS07255
gene id: 940295:EYM_RS07255
uniprot id: A0A0U3FNZ2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

940295:EYM RS04590
gene id: 940295:EYM_RS04590
uniprot id: A0A0U3FN78
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS06315
gene id: 940295:EYM_RS06315
uniprot id: A0A0U3FAJ4
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

940295:EYM RS04300
gene id: 940295:EYM_RS04300
uniprot id: A0A0U2M9N8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

940295:EYM RS00595
gene id: 940295:EYM_RS00595
uniprot id: A0A0U3G1B9
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

940295:EYM RS04535
gene id: 940295:EYM_RS04535
uniprot id: A0A0U3F6U3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS00115
gene id: 940295:EYM_RS00115
uniprot id: A0A0U3E9V9
names: Function
names: Subunit
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.

940295:EYM RS00250
gene id: 940295:EYM_RS00250
uniprot id: A0A0U3FLV2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

940295:EYM RS03945
gene id: 940295:EYM_RS03945
uniprot id: A0A0U3F6N2
names: Similarity
messages: Belongs to the UPF0273 family.

940295:EYM RS01325
gene id: 940295:EYM_RS01325
uniprot id: A0A0U3FZE9
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

940295:EYM RS04715
gene id: 940295:EYM_RS04715
uniprot id: A0A0U3G0F3
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS06345
gene id: 940295:EYM_RS06345
uniprot id: A0A0U3FR50
names: Similarity
messages: Belongs to the type IA topoisomerase family.

940295:EYM RS00720
gene id: 940295:EYM_RS00720
uniprot id: A0A0U3F1I9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

940295:EYM RS04165
gene id: 940295:EYM_RS04165
uniprot id: A0A0U3E8Q5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

940295:EYM RS05900
gene id: 940295:EYM_RS05900
uniprot id: A0A0U3F775
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

940295:EYM RS04675
gene id: 940295:EYM_RS04675
uniprot id: A0A0U3F6W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

940295:EYM RS07675
gene id: 940295:EYM_RS07675
uniprot id: A0A0U3ECA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

940295:EYM RS06665
gene id: 940295:EYM_RS06665
uniprot id: A0A0U3E9J4
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

940295:EYM RS06145
gene id: 940295:EYM_RS06145
uniprot id: A0A0U3DYM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

940295:EYM RS00845
gene id: 940295:EYM_RS00845
uniprot id: A0A0U2WKF4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homodimer.

940295:EYM RS03685
gene id: 940295:EYM_RS03685
uniprot id: A0A0U3G280
names: Similarity
messages: Belongs to the TrpF family.

940295:EYM RS03150
gene id: 940295:EYM_RS03150
uniprot id: A0A0U3FIB5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

940295:EYM RS02400
gene id: 940295:EYM_RS02400
uniprot id: A0A0U3FNK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

940295:EYM RS02205
gene id: 940295:EYM_RS02205
uniprot id: A0A0U3FI16
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

940295:EYM RS06500
gene id: 940295:EYM_RS06500
uniprot id: A0A0U2VD22
names: Similarity
messages: Belongs to the glutamate synthase family.

940295:EYM RS05575
gene id: 940295:EYM_RS05575
uniprot id: A0A0U3F9B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

940295:EYM RS06180
gene id: 940295:EYM_RS06180
uniprot id: A0A0U2WLX1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

940295:EYM RS01130
gene id: 940295:EYM_RS01130
uniprot id: A0A0U3DVJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

940295:EYM RS05080
gene id: 940295:EYM_RS05080
uniprot id: A0A0U3E1N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

940295:EYM RS04915
gene id: 940295:EYM_RS04915
uniprot id: A0A0U3E8X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

940295:EYM RS05700
gene id: 940295:EYM_RS05700
uniprot id: A0A0U3FPN8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

940295:EYM RS02055
gene id: 940295:EYM_RS02055
uniprot id: A0A0U2VE24
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS04710
gene id: 940295:EYM_RS04710
uniprot id: A0A0U3EB38
names: Similarity
messages: Belongs to the glutaredoxin family.

940295:EYM RS03580
gene id: 940295:EYM_RS03580
uniprot id: A0A0U2U699
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS06365
gene id: 940295:EYM_RS06365
uniprot id: A0A0U3EBW5
names: Similarity
messages: Belongs to the PDCD5 family.

940295:EYM RS00405
gene id: 940295:EYM_RS00405
uniprot id: A0A0U3FHK0
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS05735
gene id: 940295:EYM_RS05735
uniprot id: A0A0U3G0Q6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

940295:EYM RS06005
gene id: 940295:EYM_RS06005
uniprot id: A0A0U3FAG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

940295:EYM RS00235
gene id: 940295:EYM_RS00235
uniprot id: A0A0U3FZ30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

940295:EYM RS00170
gene id: 940295:EYM_RS00170
uniprot id: A0A0U3EA90
names: Similarity
messages: Belongs to the HupF/HypC family.

940295:EYM RS02495
gene id: 940295:EYM_RS02495
uniprot id: A0A0U2VBU2
names: Subcellular Location Annotation
messages: Nucleus

940295:EYM RS04995
gene id: 940295:EYM_RS04995
uniprot id: A0A0U3F2S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

940295:EYM RS06370
gene id: 940295:EYM_RS06370
uniprot id: A0A0U2U744
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

940295:EYM RS00230
gene id: 940295:EYM_RS00230
uniprot id: A0A0U3E0B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

940295:EYM RS05510
gene id: 940295:EYM_RS05510
uniprot id: A0A0U2U6V5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

940295:EYM RS00390
gene id: 940295:EYM_RS00390
uniprot id: A0A0U2U5C2
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

940295:EYM RS02900
gene id: 940295:EYM_RS02900
uniprot id: A0A0U3F7J4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

940295:EYM RS02895
gene id: 940295:EYM_RS02895
uniprot id: A0A0U3F6B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

940295:EYM RS07545
gene id: 940295:EYM_RS07545
uniprot id: A0A0U3F7R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

940295:EYM RS06750
gene id: 940295:EYM_RS06750
uniprot id: A0A0U3F7H1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

940295:EYM RS06520
gene id: 940295:EYM_RS06520
uniprot id: A0A0U2U761
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

940295:EYM RS04280
gene id: 940295:EYM_RS04280
uniprot id: A0A0U3DY93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

940295:EYM RS00505
gene id: 940295:EYM_RS00505
uniprot id: A0A0U3FPK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

940295:EYM RS01745
gene id: 940295:EYM_RS01745
uniprot id: A0A0U2WKP0
names: Similarity
messages: Belongs to the HerA family.

940295:EYM RS02710
gene id: 940295:EYM_RS02710
uniprot id: A0A0U3FI70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

940295:EYM RS02830
gene id: 940295:EYM_RS02830
uniprot id: A0A0U3F8Q1
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

940295:EYM RS05155
gene id: 940295:EYM_RS05155
uniprot id: A0A0U3EBL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

940295:EYM RS03340
gene id: 940295:EYM_RS03340
uniprot id: A0A0U3EAV0
names: Function
messages: Part of a potassium transport system.

940295:EYM RS05690
gene id: 940295:EYM_RS05690
uniprot id: A0A0U3F2Z0
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS01405
gene id: 940295:EYM_RS01405
uniprot id: A0A0U3F1P4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS05365
gene id: 940295:EYM_RS05365
uniprot id: A0A0U3F729
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

940295:EYM RS04595
gene id: 940295:EYM_RS04595
uniprot id: A0A0U3FQR1
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

940295:EYM RS01070
gene id: 940295:EYM_RS01070
uniprot id: A0A0U2VBH3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

940295:EYM RS06380
gene id: 940295:EYM_RS06380
uniprot id: A0A0U3FJA4
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

940295:EYM RS01215
gene id: 940295:EYM_RS01215
uniprot id: A0A0U2WKJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

940295:EYM RS07365
gene id: 940295:EYM_RS07365
uniprot id: A0A0U3FSC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

940295:EYM RS06325
gene id: 940295:EYM_RS06325
uniprot id: A0A0U3E9F6
names: Similarity
messages: Belongs to the eIF-2-alpha family.

940295:EYM RS02930
gene id: 940295:EYM_RS02930
uniprot id: A0A0U2M9E5
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

940295:EYM RS01350
gene id: 940295:EYM_RS01350
uniprot id: A0A0U3FM58
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

940295:EYM RS03760
gene id: 940295:EYM_RS03760
uniprot id: A0A0U3F2C8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

940295:EYM RS04645
gene id: 940295:EYM_RS04645
uniprot id: A0A0U2U6L7
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

940295:EYM RS03255
gene id: 940295:EYM_RS03255
uniprot id: A0A0U3FIC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

940295:EYM RS01835
gene id: 940295:EYM_RS01835
uniprot id: A0A0U3F7A3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS07390
gene id: 940295:EYM_RS07390
uniprot id: A0A0U3E9S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

940295:EYM RS05765
gene id: 940295:EYM_RS05765
uniprot id: A0A0U3FNJ0
names: Similarity
messages: Belongs to the MEMO1 family.

940295:EYM RS05235
gene id: 940295:EYM_RS05235
uniprot id: A0A0U3G0K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

940295:EYM RS07260
gene id: 940295:EYM_RS07260
uniprot id: A0A0U3FRE3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

940295:EYM RS00620
gene id: 940295:EYM_RS00620
uniprot id: A0A0U3E7P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

940295:EYM RS03770
gene id: 940295:EYM_RS03770
uniprot id: A0A0U3FP10
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

940295:EYM RS02310
gene id: 940295:EYM_RS02310
uniprot id: A0A0U3FMC6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

940295:EYM RS06820
gene id: 940295:EYM_RS06820
uniprot id: A0A0U3FNU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

940295:EYM RS07580
gene id: 940295:EYM_RS07580
uniprot id: A0A0U3F8V7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

940295:EYM RS03135
gene id: 940295:EYM_RS03135
uniprot id: A0A0U2U656
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

940295:EYM RS00660
gene id: 940295:EYM_RS00660
uniprot id: A0A0U2WME8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

940295:EYM RS02840
gene id: 940295:EYM_RS02840
uniprot id: A0A0U2WKZ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

940295:EYM RS03445
gene id: 940295:EYM_RS03445
uniprot id: A0A0U3F8V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

940295:EYM RS06840
gene id: 940295:EYM_RS06840
uniprot id: A0A0U3EC15
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

940295:EYM RS05350
gene id: 940295:EYM_RS05350
uniprot id: A0A0U3FPL1
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

940295:EYM RS02485
gene id: 940295:EYM_RS02485
uniprot id: A0A0U3FPZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

940295:EYM RS00795
gene id: 940295:EYM_RS00795
uniprot id: A0A0U3EA10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

940295:EYM RS06155
gene id: 940295:EYM_RS06155
uniprot id: A0A0U3G0T6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

940295:EYM RS02475
gene id: 940295:EYM_RS02475
uniprot id: A0A0U3E880
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

940295:EYM RS02015
gene id: 940295:EYM_RS02015
uniprot id: A0A0U3F7B7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

940295:EYM RS03310
gene id: 940295:EYM_RS03310
uniprot id: A0A0U3F9S9
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS03895
gene id: 940295:EYM_RS03895
uniprot id: A0A0U3EB88
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

940295:EYM RS00295
gene id: 940295:EYM_RS00295
uniprot id: A0A0U3FHI7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

940295:EYM RS07090
gene id: 940295:EYM_RS07090
uniprot id: A0A0U2MA58
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Heterodimer composed of an alpha and a beta subunit.

940295:EYM RS04905
gene id: 940295:EYM_RS04905
uniprot id: A0A0U3G0H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

940295:EYM RS01300
gene id: 940295:EYM_RS01300
uniprot id: A0A0U3F747
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

940295:EYM RS00025
gene id: 940295:EYM_RS00025
uniprot id: A0A0U3FPF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

940295:EYM RS03235
gene id: 940295:EYM_RS03235
uniprot id: A0A0U3EB21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

940295:EYM RS01575
gene id: 940295:EYM_RS01575
uniprot id: A0A0U3FNE0
names: Similarity
messages: Belongs to the PstS family.

940295:EYM RS07060
gene id: 940295:EYM_RS07060
uniprot id: A0A0U3EBR1
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

940295:EYM RS03265
gene id: 940295:EYM_RS03265
uniprot id: A0A0U3FNV3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

940295:EYM RS03835
gene id: 940295:EYM_RS03835
uniprot id: A0A0U3FKU5
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS04540
gene id: 940295:EYM_RS04540
uniprot id: A0A0U3F827
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

940295:EYM RS04400
gene id: 940295:EYM_RS04400
uniprot id: A0A0U3F810
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

940295:EYM RS02845
gene id: 940295:EYM_RS02845
uniprot id: A0A0U2VBX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

940295:EYM RS01890
gene id: 940295:EYM_RS01890
uniprot id: A0A0U2MAL4
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

940295:EYM RS06175
gene id: 940295:EYM_RS06175
uniprot id: A0A0U3FR31
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

940295:EYM RS00165
gene id: 940295:EYM_RS00165
uniprot id: A0A0U2VB33
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS00375
gene id: 940295:EYM_RS00375
uniprot id: A0A0U2WK88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

940295:EYM RS05370
gene id: 940295:EYM_RS05370
uniprot id: A0A0U3E822
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

940295:EYM RS03275
gene id: 940295:EYM_RS03275
uniprot id: A0A0U2U8M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

940295:EYM RS03160
gene id: 940295:EYM_RS03160
uniprot id: A0A0U3F6E6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

940295:EYM RS06765
gene id: 940295:EYM_RS06765
uniprot id: A0A0U3DWW6
names: Similarity
messages: Belongs to the UPF0201 family.

940295:EYM RS05185
gene id: 940295:EYM_RS05185
uniprot id: A0A0U3FIX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

940295:EYM RS03120
gene id: 940295:EYM_RS03120
uniprot id: A0A0U2MAV0
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS03230
gene id: 940295:EYM_RS03230
uniprot id: A0A0U2VC25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

940295:EYM RS04405
gene id: 940295:EYM_RS04405
uniprot id: A0A0U3DWB3
names: Similarity
messages: Belongs to the UPF0235 family.

940295:EYM RS03370
gene id: 940295:EYM_RS03370
uniprot id: A0A0U3E8G5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

940295:EYM RS01190
gene id: 940295:EYM_RS01190
uniprot id: A0A0U3FM32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

940295:EYM RS04310
gene id: 940295:EYM_RS04310
uniprot id: A0A0U3FN18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

940295:EYM RS03790
gene id: 940295:EYM_RS03790
uniprot id: A0A0U3F7V0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

940295:EYM RS02090
gene id: 940295:EYM_RS02090
uniprot id: A0A0U3F417
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS02975
gene id: 940295:EYM_RS02975
uniprot id: A0A0U2WL04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

940295:EYM RS03890
gene id: 940295:EYM_RS03890
uniprot id: A0A0U2VC85
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

940295:EYM RS07680
gene id: 940295:EYM_RS07680
uniprot id: A0A0U3FTM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

940295:EYM RS03245
gene id: 940295:EYM_RS03245
uniprot id: A0A0U3F275
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

940295:EYM RS06125
gene id: 940295:EYM_RS06125
uniprot id: A0A0U3F8G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

940295:EYM RS04000
gene id: 940295:EYM_RS04000
uniprot id: A0A0U3E8N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

940295:EYM RS03540
gene id: 940295:EYM_RS03540
uniprot id: A0A0U3FQE8
names: Similarity
messages: Belongs to the UPF0047 family.

940295:EYM RS06040
gene id: 940295:EYM_RS06040
uniprot id: A0A0U2U702
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS02935
gene id: 940295:EYM_RS02935
uniprot id: A0A0U3E8C8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

940295:EYM RS04970
gene id: 940295:EYM_RS04970
uniprot id: A0A0U3EBJ3
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

940295:EYM RS00995
gene id: 940295:EYM_RS00995
uniprot id: A0A0U3FZC2
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

940295:EYM RS00190
gene id: 940295:EYM_RS00190
uniprot id: A0A0U3FHH2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

940295:EYM RS04485
gene id: 940295:EYM_RS04485
uniprot id: A0A0U3DYA0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS03175
gene id: 940295:EYM_RS03175
uniprot id: A0A0U2U9Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

940295:EYM RS07100
gene id: 940295:EYM_RS07100
uniprot id: A0A0U3E9P2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

940295:EYM RS04805
gene id: 940295:EYM_RS04805
uniprot id: A0A0U3FA42
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

940295:EYM RS05655
gene id: 940295:EYM_RS05655
uniprot id: A0A0U3EDV3
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS03780
gene id: 940295:EYM_RS03780
uniprot id: A0A0U2WNC1
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS02645
gene id: 940295:EYM_RS02645
uniprot id: A0A0U3E8B4
names: Similarity
messages: Belongs to the archaeal-type GPI family.

940295:EYM RS00080
gene id: 940295:EYM_RS00080
uniprot id: A0A0U3FMY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

940295:EYM RS03650
gene id: 940295:EYM_RS03650
uniprot id: A0A0U3E194
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

940295:EYM RS02865
gene id: 940295:EYM_RS02865
uniprot id: A0A0U2U619
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

940295:EYM RS03470
gene id: 940295:EYM_RS03470
uniprot id: A0A0U3F7Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

940295:EYM RS03165
gene id: 940295:EYM_RS03165
uniprot id: A0A0U3F7M7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

940295:EYM RS06865
gene id: 940295:EYM_RS06865
uniprot id: A0A0U3FPZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

940295:EYM RS05960
gene id: 940295:EYM_RS05960
uniprot id: A0A0U3E1W3
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS01700
gene id: 940295:EYM_RS01700
uniprot id: A0A0U2U819
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

940295:EYM RS07625
gene id: 940295:EYM_RS07625
uniprot id: A0A0U3FP31
names: Similarity
messages: Belongs to the AOR/FOR family.

940295:EYM RS06735
gene id: 940295:EYM_RS06735
uniprot id: A0A0U3F382
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

940295:EYM RS00565
gene id: 940295:EYM_RS00565
uniprot id: A0A0U3F5Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

940295:EYM RS03880
gene id: 940295:EYM_RS03880
uniprot id: A0A0U2WLA0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

940295:EYM RS04475
gene id: 940295:EYM_RS04475
uniprot id: A0A0U3EBE4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

940295:EYM RS05395
gene id: 940295:EYM_RS05395
uniprot id: A0A0U3G0L8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

940295:EYM RS06700
gene id: 940295:EYM_RS06700
uniprot id: A0A0U3FR79
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS07130
gene id: 940295:EYM_RS07130
uniprot id: A0A0U3FRD0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

940295:EYM RS01600
gene id: 940295:EYM_RS01600
uniprot id: A0A0U3DVN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

940295:EYM RS03155
gene id: 940295:EYM_RS03155
uniprot id: A0A0U3FNT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

940295:EYM RS03240
gene id: 940295:EYM_RS03240
uniprot id: A0A0U2U670
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

940295:EYM RS02790
gene id: 940295:EYM_RS02790
uniprot id: A0A0U3E8B8
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

940295:EYM RS03690
gene id: 940295:EYM_RS03690
uniprot id: A0A0U3E8K2
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS05335
gene id: 940295:EYM_RS05335
uniprot id: A0A0U3FIZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

940295:EYM RS02280
gene id: 940295:EYM_RS02280
uniprot id: A0A0U3E0V5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS05930
gene id: 940295:EYM_RS05930
uniprot id: A0A0U3DWP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

940295:EYM RS04045
gene id: 940295:EYM_RS04045
uniprot id: A0A0U3FQJ1
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

940295:EYM RS07290
gene id: 940295:EYM_RS07290
uniprot id: A0A0U3F3E0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

940295:EYM RS05050
gene id: 940295:EYM_RS05050
uniprot id: A0A0U3FPH9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

940295:EYM RS01930
gene id: 940295:EYM_RS01930
uniprot id: A0A0U3ECU7
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS05880
gene id: 940295:EYM_RS05880
uniprot id: A0A0U2U6Y7
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

940295:EYM RS01145
gene id: 940295:EYM_RS01145
uniprot id: A0A0U3FQL8
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

940295:EYM RS07235
gene id: 940295:EYM_RS07235
uniprot id: A0A0U3E9Q7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

940295:EYM RS00380
gene id: 940295:EYM_RS00380
uniprot id: A0A0U2VBA8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

940295:EYM RS03140
gene id: 940295:EYM_RS03140
uniprot id: A0A0U3F253
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

940295:EYM RS00600
gene id: 940295:EYM_RS00600
uniprot id: A0A0U3E0H2
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS07315
gene id: 940295:EYM_RS07315
uniprot id: A0A0U3FQ31
names: Similarity
messages: Belongs to the DtxR/MntR family.

940295:EYM RS01230
gene id: 940295:EYM_RS01230
uniprot id: A0A0U2VBI5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

940295:EYM RS02500
gene id: 940295:EYM_RS02500
uniprot id: A0A0U3EAV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

940295:EYM RS04690
gene id: 940295:EYM_RS04690
uniprot id: A0A0U3E1K8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

940295:EYM RS01455
gene id: 940295:EYM_RS01455
uniprot id: A0A0U2M956
names: Similarity
messages: Belongs to the AAA ATPase family.

940295:EYM RS06300
gene id: 940295:EYM_RS06300
uniprot id: A0A0U3FLJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

940295:EYM RS04395
gene id: 940295:EYM_RS04395
uniprot id: A0A0U3F6S7
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

940295:EYM RS03565
gene id: 940295:EYM_RS03565
uniprot id: A0A0U3FSG3
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS02715
gene id: 940295:EYM_RS02715
uniprot id: A0A0U3FNN7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

940295:EYM RS05475
gene id: 940295:EYM_RS05475
uniprot id: A0A0U2VCS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

940295:EYM RS00445
gene id: 940295:EYM_RS00445
uniprot id: A0A0U3E0F4
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

940295:EYM RS04010
gene id: 940295:EYM_RS04010
uniprot id: A0A0U3F4J4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

940295:EYM RS03610
gene id: 940295:EYM_RS03610
uniprot id: A0A0U3F4G5
names: Similarity
messages: Belongs to the aspartokinase family.

940295:EYM RS04515
gene id: 940295:EYM_RS04515
uniprot id: A0A0U3FIR5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

940295:EYM RS06080
gene id: 940295:EYM_RS06080
uniprot id: A0A0U3F7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

940295:EYM RS06830
gene id: 940295:EYM_RS06830
uniprot id: A0A0U2WM17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

940295:EYM RS06755
gene id: 940295:EYM_RS06755
uniprot id: A0A0U3F8N4
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

940295:EYM RS06885
gene id: 940295:EYM_RS06885
uniprot id: A0A0U3DWY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

940295:EYM RS06925
gene id: 940295:EYM_RS06925
uniprot id: A0A0U3FNW1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

940295:EYM RS04635
gene id: 940295:EYM_RS04635
uniprot id: A0A0U3F941
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

940295:EYM RS00880
gene id: 940295:EYM_RS00880
uniprot id: A0A0U3FQI1
names: Subcellular Location Annotation
messages: Membrane

940295:EYM RS07535
gene id: 940295:EYM_RS07535
uniprot id: A0A0U3FQ46
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

940295:EYM RS02170
gene id: 940295:EYM_RS02170
uniprot id: A0A0U2U5V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

940295:EYM RS06845
gene id: 940295:EYM_RS06845
uniprot id: A0A0U2U795
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

940295:EYM RS03870
gene id: 940295:EYM_RS03870
uniprot id: A0A0U3FQH7
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

940295:EYM RS04910
gene id: 940295:EYM_RS04910
uniprot id: A0A0U2M9S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

940295:EYM RS07320
gene id: 940295:EYM_RS07320
uniprot id: A0A0U3F7P4
names: Similarity
messages: Belongs to the UPF0045 family.

940295:EYM RS04055
gene id: 940295:EYM_RS04055
uniprot id: A0A0U2VC96
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

940295:EYM RS01345
gene id: 940295:EYM_RS01345
uniprot id: A0A0U3E7W8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

940295:EYM RS07030
gene id: 940295:EYM_RS07030
uniprot id: A0A0U3DWZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

940295:EYM RS03775
gene id: 940295:EYM_RS03775
uniprot id: A0A0U3F6L4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

940295:EYM RS06410
gene id: 940295:EYM_RS06410
uniprot id: A0A0U3F8K3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

940295:EYM RS04350
gene id: 940295:EYM_RS04350
uniprot id: A0A0U3FSM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

940295:EYM RS01885
gene id: 940295:EYM_RS01885
uniprot id: A0A0U3FMA5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

940295:EYM RS03900
gene id: 940295:EYM_RS03900
uniprot id: A0A0U2U6C7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

940295:EYM RS05710
gene id: 940295:EYM_RS05710
uniprot id: A0A0U3F8D4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

940295:EYM RS02050
gene id: 940295:EYM_RS02050
uniprot id: A0A0U3E0T8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

940295:EYM RS05015
gene id: 940295:EYM_RS05015
uniprot id: A0A0U3FIV7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

940295:EYM RS06260
gene id: 940295:EYM_RS06260
uniprot id: A0A0U3F8I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.