926571:NVIE RS07730
gene id: 926571:NVIE_RS07730
uniprot id: A0A060HK04
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS11630
gene id: 926571:NVIE_RS11630
uniprot id: A0A060HUA7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

926571:NVIE RS10990
gene id: 926571:NVIE_RS10990
uniprot id: A0A060HN08
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

926571:NVIE RS13585
gene id: 926571:NVIE_RS13585
uniprot id: A0A060HKS5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

926571:NVIE RS12230
gene id: 926571:NVIE_RS12230
uniprot id: A0A060HUS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

926571:NVIE RS02475
gene id: 926571:NVIE_RS02475
uniprot id: A0A060HNA6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

926571:NVIE RS14075
gene id: 926571:NVIE_RS14075
uniprot id: A0A060HQ20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

926571:NVIE RS08875
gene id: 926571:NVIE_RS08875
uniprot id: A0A060HKS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

926571:NVIE RS10585
gene id: 926571:NVIE_RS10585
uniprot id: A0A060HTP4
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

926571:NVIE RS00675
gene id: 926571:NVIE_RS00675
uniprot id: A0A060HG29
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

926571:NVIE RS07875
gene id: 926571:NVIE_RS07875
uniprot id: A0A060HH16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

926571:NVIE RS02270
gene id: 926571:NVIE_RS02270
uniprot id: A0A060HGD1
names: Similarity
messages: Belongs to the UPF0111 family.

926571:NVIE RS14430
gene id: 926571:NVIE_RS14430
uniprot id: A0A060HWA1
names: Similarity
messages: Belongs to the UPF0045 family.

926571:NVIE RS08635
gene id: 926571:NVIE_RS08635
uniprot id: A0A060HSA2
names: Subunit
messages: Homotrimer.

926571:NVIE RS05165
gene id: 926571:NVIE_RS05165
uniprot id: A0A060HF77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

926571:NVIE RS05200
gene id: 926571:NVIE_RS05200
uniprot id: A0A060HIE3
names: Similarity
messages: Belongs to the glutaredoxin family.

926571:NVIE RS04760
gene id: 926571:NVIE_RS04760
uniprot id: A0A060HIQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

926571:NVIE RS12955
gene id: 926571:NVIE_RS12955
uniprot id: A0A060HU81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

926571:NVIE RS08615
gene id: 926571:NVIE_RS08615
uniprot id: A0A060HKM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

926571:NVIE RS06450
gene id: 926571:NVIE_RS06450
uniprot id: A0A060HPU0
names: Similarity
messages: Belongs to the P(II) protein family.

926571:NVIE RS14010
gene id: 926571:NVIE_RS14010
uniprot id: A0A060HVY7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

926571:NVIE RS01650
gene id: 926571:NVIE_RS01650
uniprot id: A0A060HCS0
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

926571:NVIE RS13315
gene id: 926571:NVIE_RS13315
uniprot id: A0A060HVI3
names: Similarity
messages: Belongs to the peptidase S1C family.

926571:NVIE RS00200
gene id: 926571:NVIE_RS00200
uniprot id: A0A060HF15
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

926571:NVIE RS05625
gene id: 926571:NVIE_RS05625
uniprot id: A0A060HPD0
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

926571:NVIE RS11265
gene id: 926571:NVIE_RS11265
uniprot id: A0A060HT02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

926571:NVIE RS07110
gene id: 926571:NVIE_RS07110
uniprot id: A0A060HGF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

926571:NVIE RS14370
gene id: 926571:NVIE_RS14370
uniprot id: A0A060HQ85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

926571:NVIE RS04060
gene id: 926571:NVIE_RS04060
uniprot id: A0A060HIC1
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

926571:NVIE RS01840
gene id: 926571:NVIE_RS01840
uniprot id: A0A060HGU8
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

926571:NVIE RS04810
gene id: 926571:NVIE_RS04810
uniprot id: A0A060HNS2
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

926571:NVIE RS06525
gene id: 926571:NVIE_RS06525
uniprot id: A0A060HPV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

926571:NVIE RS14455
gene id: 926571:NVIE_RS14455
uniprot id: A0A060HP76
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS06735
gene id: 926571:NVIE_RS06735
uniprot id: A0A060HR20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

926571:NVIE RS06720
gene id: 926571:NVIE_RS06720
uniprot id: A0A060HG65
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

926571:NVIE RS11565
gene id: 926571:NVIE_RS11565
uniprot id: A0A060HJD6
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

926571:NVIE RS07755
gene id: 926571:NVIE_RS07755
uniprot id: A0A060HGY7
names: Similarity
messages: Belongs to the carbamate kinase family.

926571:NVIE RS07060
gene id: 926571:NVIE_RS07060
uniprot id: A0A060HJI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

926571:NVIE RS04020
gene id: 926571:NVIE_RS04020
uniprot id: A0A060HPB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

926571:NVIE RS02370
gene id: 926571:NVIE_RS02370
uniprot id: A0A060HN82
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

926571:NVIE RS02840
gene id: 926571:NVIE_RS02840
uniprot id: A0A060HHF2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS07960
gene id: 926571:NVIE_RS07960
uniprot id: A0A060HL07
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

926571:NVIE RS00140
gene id: 926571:NVIE_RS00140
uniprot id: A0A060HKU7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

926571:NVIE RS02380
gene id: 926571:NVIE_RS02380
uniprot id: A0A060HD71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS12630
gene id: 926571:NVIE_RS12630
uniprot id: A0A060HV62
names: Subcellular Location Annotation
messages: Cell membrane

926571:NVIE RS10665
gene id: 926571:NVIE_RS10665
uniprot id: A0A060HLY9
names: Similarity
messages: Belongs to the HsdR family.

926571:NVIE RS13095
gene id: 926571:NVIE_RS13095
uniprot id: A0A060HVE8
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

926571:NVIE RS02615
gene id: 926571:NVIE_RS02615
uniprot id: A0A060HNE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

926571:NVIE RS15995
gene id: 926571:NVIE_RS15995
uniprot id: A0A060HW94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

926571:NVIE RS08325
gene id: 926571:NVIE_RS08325
uniprot id: A0A060HS43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

926571:NVIE RS00770
gene id: 926571:NVIE_RS00770
uniprot id: A0A060HL74
names: Similarity
messages: Belongs to the SUI1 family.

926571:NVIE RS05760
gene id: 926571:NVIE_RS05760
uniprot id: A0A060HIT2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS02815
gene id: 926571:NVIE_RS02815
uniprot id: A0A060HHE7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

926571:NVIE RS09890
gene id: 926571:NVIE_RS09890
uniprot id: A0A060HT42
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

926571:NVIE RS03725
gene id: 926571:NVIE_RS03725
uniprot id: A0A060HE93
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

926571:NVIE RS12660
gene id: 926571:NVIE_RS12660
uniprot id: A0A060HN96
names: Similarity
messages: Belongs to the UPF0111 family.

926571:NVIE RS02820
gene id: 926571:NVIE_RS02820
uniprot id: A0A060HMH8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

926571:NVIE RS04500
gene id: 926571:NVIE_RS04500
uniprot id: A0A060HNK5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

926571:NVIE RS13790
gene id: 926571:NVIE_RS13790
uniprot id: A0A060HNV7
names: Similarity
messages: Belongs to the AHA1 family.

926571:NVIE RS10870
gene id: 926571:NVIE_RS10870
uniprot id: A0A060HM29
names: Similarity
messages: Belongs to the DEAD box helicase family.

926571:NVIE RS14000
gene id: 926571:NVIE_RS14000
uniprot id: A0A060HQ01
names: Caution
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS09690
gene id: 926571:NVIE_RS09690
uniprot id: A0A060HL94
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

926571:NVIE RS11615
gene id: 926571:NVIE_RS11615
uniprot id: A0A060HJE7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

926571:NVIE RS10045
gene id: 926571:NVIE_RS10045
uniprot id: A0A060HT84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

926571:NVIE RS03275
gene id: 926571:NVIE_RS03275
uniprot id: A0A060HHV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

926571:NVIE RS01290
gene id: 926571:NVIE_RS01290
uniprot id: A0A060HMP5
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

926571:NVIE RS05750
gene id: 926571:NVIE_RS05750
uniprot id: A0A060HPG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

926571:NVIE RS06590
gene id: 926571:NVIE_RS06590
uniprot id: A0A060HJ97
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

926571:NVIE RS00210
gene id: 926571:NVIE_RS00210
uniprot id: A0A060HFR5
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

926571:NVIE RS06770
gene id: 926571:NVIE_RS06770
uniprot id: A0A060HG74
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

926571:NVIE RS06760
gene id: 926571:NVIE_RS06760
uniprot id: A0A060HR24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

926571:NVIE RS04185
gene id: 926571:NVIE_RS04185
uniprot id: A0A060HHN8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

926571:NVIE RS05180
gene id: 926571:NVIE_RS05180
uniprot id: A0A060HID7
names: Similarity
messages: Belongs to the UPF0166 family.

926571:NVIE RS07735
gene id: 926571:NVIE_RS07735
uniprot id: A0A060HGY1
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS04175
gene id: 926571:NVIE_RS04175
uniprot id: A0A060HND7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

926571:NVIE RS05635
gene id: 926571:NVIE_RS05635
uniprot id: A0A060HIR2
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

926571:NVIE RS11830
gene id: 926571:NVIE_RS11830
uniprot id: A0A060HUF2
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS02730
gene id: 926571:NVIE_RS02730
uniprot id: A0A060HMF5
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

926571:NVIE RS07445
gene id: 926571:NVIE_RS07445
uniprot id: A0A060HRE7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

926571:NVIE RS02140
gene id: 926571:NVIE_RS02140
uniprot id: A0A060HM31
names: Similarity
messages: Belongs to the eIF-2-alpha family.

926571:NVIE RS01570
gene id: 926571:NVIE_RS01570
uniprot id: A0A060HMU1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

926571:NVIE RS06515
gene id: 926571:NVIE_RS06515
uniprot id: A0A060HG35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS06745
gene id: 926571:NVIE_RS06745
uniprot id: A0A060HG71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

926571:NVIE RS08990
gene id: 926571:NVIE_RS08990
uniprot id: A0A060HKU4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

926571:NVIE RS00100
gene id: 926571:NVIE_RS00100
uniprot id: A0A060HEZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

926571:NVIE RS13510
gene id: 926571:NVIE_RS13510
uniprot id: A0A060HNQ5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

926571:NVIE RS06995
gene id: 926571:NVIE_RS06995
uniprot id: A0A060HK55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS13530
gene id: 926571:NVIE_RS13530
uniprot id: A0A060HVM6
names: Similarity
messages: Belongs to the TOP6A family.

926571:NVIE RS14025
gene id: 926571:NVIE_RS14025
uniprot id: A0A060HQ08
names: Similarity
messages: Belongs to the phosphohexose mutase family.

926571:NVIE RS14005
gene id: 926571:NVIE_RS14005
uniprot id: A0A060HUV7
names: Similarity
messages: Belongs to the NDK family.

926571:NVIE RS07680
gene id: 926571:NVIE_RS07680
uniprot id: A0A060HRK6
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS03685
gene id: 926571:NVIE_RS03685
uniprot id: A0A060HP60
names: Similarity
messages: Belongs to the CutA family.

926571:NVIE RS10390
gene id: 926571:NVIE_RS10390
uniprot id: A0A060HSK4
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

926571:NVIE RS11735
gene id: 926571:NVIE_RS11735
uniprot id: A0A060HUD1
names: Similarity
messages: Belongs to the UPF0235 family.

926571:NVIE RS05590
gene id: 926571:NVIE_RS05590
uniprot id: A0A060HFK6
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS07290
gene id: 926571:NVIE_RS07290
uniprot id: A0A060HQC5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.

926571:NVIE RS03470
gene id: 926571:NVIE_RS03470
uniprot id: A0A060HHB0
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS11500
gene id: 926571:NVIE_RS11500
uniprot id: A0A060HMF2
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

926571:NVIE RS07800
gene id: 926571:NVIE_RS07800
uniprot id: A0A060HK20
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS02125
gene id: 926571:NVIE_RS02125
uniprot id: A0A060HGA2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

926571:NVIE RS02885
gene id: 926571:NVIE_RS02885
uniprot id: A0A060HHG5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

926571:NVIE RS02540
gene id: 926571:NVIE_RS02540
uniprot id: A0A060HH76
names: Similarity
messages: Belongs to the SAICAR synthetase family.

926571:NVIE RS04835
gene id: 926571:NVIE_RS04835
uniprot id: A0A060HNS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

926571:NVIE RS12065
gene id: 926571:NVIE_RS12065
uniprot id: A0A060HJS1
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

926571:NVIE RS07300
gene id: 926571:NVIE_RS07300
uniprot id: A0A060HJQ2
names: Similarity
messages: Belongs to the citrate synthase family.

926571:NVIE RS06740
gene id: 926571:NVIE_RS06740
uniprot id: A0A060HJD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

926571:NVIE RS08530
gene id: 926571:NVIE_RS08530
uniprot id: A0A060HLB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

926571:NVIE RS04925
gene id: 926571:NVIE_RS04925
uniprot id: A0A060HF00
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

926571:NVIE RS13630
gene id: 926571:NVIE_RS13630
uniprot id: A0A060HPR4
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS05310
gene id: 926571:NVIE_RS05310
uniprot id: A0A060HQ69
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

926571:NVIE RS04180
gene id: 926571:NVIE_RS04180
uniprot id: A0A060HPD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

926571:NVIE RS10670
gene id: 926571:NVIE_RS10670
uniprot id: A0A060HIS5
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

926571:NVIE RS08020
gene id: 926571:NVIE_RS08020
uniprot id: A0A060HRX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS01835
gene id: 926571:NVIE_RS01835
uniprot id: A0A060HCV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

926571:NVIE RS12215
gene id: 926571:NVIE_RS12215
uniprot id: A0A060HJW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

926571:NVIE RS10430
gene id: 926571:NVIE_RS10430
uniprot id: A0A060HMS6
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

926571:NVIE RS10755
gene id: 926571:NVIE_RS10755
uniprot id: A0A060HM07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

926571:NVIE RS10520
gene id: 926571:NVIE_RS10520
uniprot id: A0A060HIQ7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

926571:NVIE RS12345
gene id: 926571:NVIE_RS12345
uniprot id: A0A060HTT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

926571:NVIE RS03220
gene id: 926571:NVIE_RS03220
uniprot id: A0A060HMR4
names: Similarity
messages: Belongs to the UPF0147 family.

926571:NVIE RS05345
gene id: 926571:NVIE_RS05345
uniprot id: A0A060HFD4
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

926571:NVIE RS13000
gene id: 926571:NVIE_RS13000
uniprot id: A0A060HVC9
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

926571:NVIE RS00130
gene id: 926571:NVIE_RS00130
uniprot id: A0A060HBQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

926571:NVIE RS03630
gene id: 926571:NVIE_RS03630
uniprot id: A0A060HI51
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

926571:NVIE RS05585
gene id: 926571:NVIE_RS05585
uniprot id: A0A060HIP0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

926571:NVIE RS01685
gene id: 926571:NVIE_RS01685
uniprot id: A0A060HLS2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS08225
gene id: 926571:NVIE_RS08225
uniprot id: A0A060HL75
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS07835
gene id: 926571:NVIE_RS07835
uniprot id: A0A060HKW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

926571:NVIE RS06485
gene id: 926571:NVIE_RS06485
uniprot id: A0A060HJ77
names: Subcellular Location Annotation
messages: Nucleus

926571:NVIE RS08370
gene id: 926571:NVIE_RS08370
uniprot id: A0A060HR46
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase involved in purine salvage.

926571:NVIE RS06280
gene id: 926571:NVIE_RS06280
uniprot id: A0A060HFZ3
names: Similarity
messages: Belongs to the DEAD box helicase family.

926571:NVIE RS03940
gene id: 926571:NVIE_RS03940
uniprot id: A0A060HED0
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

926571:NVIE RS11420
gene id: 926571:NVIE_RS11420
uniprot id: A0A060HT36
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

926571:NVIE RS00060
gene id: 926571:NVIE_RS00060
uniprot id: A0A060HFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

926571:NVIE RS02505
gene id: 926571:NVIE_RS02505
uniprot id: A0A060HGI5
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

926571:NVIE RS10525
gene id: 926571:NVIE_RS10525
uniprot id: A0A060HMU3
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

926571:NVIE RS01380
gene id: 926571:NVIE_RS01380
uniprot id: A0A060HGL2
names: Similarity
messages: Belongs to the archease family.

926571:NVIE RS05525
gene id: 926571:NVIE_RS05525
uniprot id: A0A060HQC1
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS07005
gene id: 926571:NVIE_RS07005
uniprot id: A0A060HR72
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Homooctamer; dimer of tetramers.

926571:NVIE RS04165
gene id: 926571:NVIE_RS04165
uniprot id: A0A060HEH8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

926571:NVIE RS00105
gene id: 926571:NVIE_RS00105
uniprot id: A0A060HBP6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

926571:NVIE RS13085
gene id: 926571:NVIE_RS13085
uniprot id: A0A060HPE7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

926571:NVIE RS02650
gene id: 926571:NVIE_RS02650
uniprot id: A0A060HHA7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

926571:NVIE RS00025
gene id: 926571:NVIE_RS00025
uniprot id: A0A060HEX9
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

926571:NVIE RS02675
gene id: 926571:NVIE_RS02675
uniprot id: A0A060HHB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

926571:NVIE RS11995
gene id: 926571:NVIE_RS11995
uniprot id: A0A060HNQ6
names: Similarity
messages: Belongs to the UPF0201 family.

926571:NVIE RS03385
gene id: 926571:NVIE_RS03385
uniprot id: A0A060HMZ5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS04160
gene id: 926571:NVIE_RS04160
uniprot id: A0A060HHN2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

926571:NVIE RS03735
gene id: 926571:NVIE_RS03735
uniprot id: A0A060HN46
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

926571:NVIE RS10305
gene id: 926571:NVIE_RS10305
uniprot id: A0A060HTJ5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

926571:NVIE RS09765
gene id: 926571:NVIE_RS09765
uniprot id: A0A060HRZ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

926571:NVIE RS13970
gene id: 926571:NVIE_RS13970
uniprot id: A0A060HNY9
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS13370
gene id: 926571:NVIE_RS13370
uniprot id: A0A060HNM8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

926571:NVIE RS02085
gene id: 926571:NVIE_RS02085
uniprot id: A0A060HM19
names: Similarity
messages: Belongs to the AdoMet synthase family.

926571:NVIE RS07565
gene id: 926571:NVIE_RS07565
uniprot id: A0A060HQH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

926571:NVIE RS01615
gene id: 926571:NVIE_RS01615
uniprot id: A0A060HMU9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

926571:NVIE RS10565
gene id: 926571:NVIE_RS10565
uniprot id: A0A060HLX1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

926571:NVIE RS08190
gene id: 926571:NVIE_RS08190
uniprot id: A0A060HKE9
names: Similarity
messages: Belongs to the HerA family.

926571:NVIE RS02440
gene id: 926571:NVIE_RS02440
uniprot id: A0A060HH61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS01125
gene id: 926571:NVIE_RS01125
uniprot id: A0A060HLI2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

926571:NVIE RS13180
gene id: 926571:NVIE_RS13180
uniprot id: A0A060HPG5
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 2 family.

926571:NVIE RS08975
gene id: 926571:NVIE_RS08975
uniprot id: A0A060HHM4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

926571:NVIE RS11545
gene id: 926571:NVIE_RS11545
uniprot id: A0A060HU84
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS01890
gene id: 926571:NVIE_RS01890
uniprot id: A0A060HG53
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

926571:NVIE RS13345
gene id: 926571:NVIE_RS13345
uniprot id: A0A060HNM3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS02315
gene id: 926571:NVIE_RS02315
uniprot id: A0A060HN71
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS10630
gene id: 926571:NVIE_RS10630
uniprot id: A0A060HSP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

926571:NVIE RS12100
gene id: 926571:NVIE_RS12100
uniprot id: A0A060HTL8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

926571:NVIE RS13265
gene id: 926571:NVIE_RS13265
uniprot id: A0A060HUE4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

926571:NVIE RS12340
gene id: 926571:NVIE_RS12340
uniprot id: A0A060HNZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

926571:NVIE RS11665
gene id: 926571:NVIE_RS11665
uniprot id: A0A060HJF8
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

926571:NVIE RS01665
gene id: 926571:NVIE_RS01665
uniprot id: A0A060HMV6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Membrane

926571:NVIE RS05965
gene id: 926571:NVIE_RS05965
uniprot id: A0A060HJM9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

926571:NVIE RS00995
gene id: 926571:NVIE_RS00995
uniprot id: A0A060HFM6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

926571:NVIE RS02520
gene id: 926571:NVIE_RS02520
uniprot id: A0A060HMB0
names: Similarity
messages: Belongs to the peptidase T1A family.

926571:NVIE RS08025
gene id: 926571:NVIE_RS08025
uniprot id: A0A060HKA9
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

926571:NVIE RS05950
gene id: 926571:NVIE_RS05950
uniprot id: A0A060HQM4
names: Similarity
messages: Belongs to the TFIIB family.

926571:NVIE RS01950
gene id: 926571:NVIE_RS01950
uniprot id: A0A060HLZ0
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS03620
gene id: 926571:NVIE_RS03620
uniprot id: A0A060HHD4
names: Function
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

926571:NVIE RS12940
gene id: 926571:NVIE_RS12940
uniprot id: A0A060HNE5
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS02465
gene id: 926571:NVIE_RS02465
uniprot id: A0A060HH64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS07100
gene id: 926571:NVIE_RS07100
uniprot id: A0A060HR88
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

926571:NVIE RS07460
gene id: 926571:NVIE_RS07460
uniprot id: A0A060HGQ0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

926571:NVIE RS05620
gene id: 926571:NVIE_RS05620
uniprot id: A0A060HJG6
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS05680
gene id: 926571:NVIE_RS05680
uniprot id: A0A060HIS0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

926571:NVIE RS11270
gene id: 926571:NVIE_RS11270
uniprot id: A0A060HU26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

926571:NVIE RS02320
gene id: 926571:NVIE_RS02320
uniprot id: A0A060HGE2
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

926571:NVIE RS05290
gene id: 926571:NVIE_RS05290
uniprot id: A0A060HQ62
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

926571:NVIE RS03625
gene id: 926571:NVIE_RS03625
uniprot id: A0A060HE79
names: Function
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

926571:NVIE RS10825
gene id: 926571:NVIE_RS10825
uniprot id: A0A060HM20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

926571:NVIE RS04025
gene id: 926571:NVIE_RS04025
uniprot id: A0A060HHK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

926571:NVIE RS01385
gene id: 926571:NVIE_RS01385
uniprot id: A0A060HLM5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

926571:NVIE RS00760
gene id: 926571:NVIE_RS00760
uniprot id: A0A060HC39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

926571:NVIE RS14175
gene id: 926571:NVIE_RS14175
uniprot id: A0A060HP22
names: Similarity
messages: Belongs to the Ahb/Nir family.

926571:NVIE RS11060
gene id: 926571:NVIE_RS11060
uniprot id: A0A060HN20
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS11000
gene id: 926571:NVIE_RS11000
uniprot id: A0A060HTX6
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

926571:NVIE RS01250
gene id: 926571:NVIE_RS01250
uniprot id: A0A060HCJ8
names: Function
messages: Involved in the transposition of the insertion sequence.

926571:NVIE RS02210
gene id: 926571:NVIE_RS02210
uniprot id: A0A060HM48
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS08415
gene id: 926571:NVIE_RS08415
uniprot id: A0A060HR54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

926571:NVIE RS10375
gene id: 926571:NVIE_RS10375
uniprot id: A0A060HLU1
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

926571:NVIE RS13985
gene id: 926571:NVIE_RS13985
uniprot id: A0A060HVY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

926571:NVIE RS05710
gene id: 926571:NVIE_RS05710
uniprot id: A0A060HIS3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

926571:NVIE RS10160
gene id: 926571:NVIE_RS10160
uniprot id: A0A060HTC3
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

926571:NVIE RS01655
gene id: 926571:NVIE_RS01655
uniprot id: A0A060HGR4
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

926571:NVIE RS14020
gene id: 926571:NVIE_RS14020
uniprot id: A0A060HL12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

926571:NVIE RS00805
gene id: 926571:NVIE_RS00805
uniprot id: A0A060HFI0
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS05175
gene id: 926571:NVIE_RS05175
uniprot id: A0A060HQ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

926571:NVIE RS08170
gene id: 926571:NVIE_RS08170
uniprot id: A0A060HH86
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

926571:NVIE RS11645
gene id: 926571:NVIE_RS11645
uniprot id: A0A060HNF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

926571:NVIE RS11280
gene id: 926571:NVIE_RS11280
uniprot id: A0A060HJ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

926571:NVIE RS03965
gene id: 926571:NVIE_RS03965
uniprot id: A0A060HED3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS03095
gene id: 926571:NVIE_RS03095
uniprot id: A0A060HNR8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

926571:NVIE RS13425
gene id: 926571:NVIE_RS13425
uniprot id: A0A060HNN7
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

926571:NVIE RS01170
gene id: 926571:NVIE_RS01170
uniprot id: A0A060HGH5
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

926571:NVIE RS02760
gene id: 926571:NVIE_RS02760
uniprot id: A0A060HNI0
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

926571:NVIE RS00295
gene id: 926571:NVIE_RS00295
uniprot id: A0A060HM32
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS10535
gene id: 926571:NVIE_RS10535
uniprot id: A0A060HTN5
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

926571:NVIE RS10995
gene id: 926571:NVIE_RS10995
uniprot id: A0A060HSU8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

926571:NVIE RS05605
gene id: 926571:NVIE_RS05605
uniprot id: A0A060HQE4
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS11245
gene id: 926571:NVIE_RS11245
uniprot id: A0A060HU21
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

926571:NVIE RS13270
gene id: 926571:NVIE_RS13270
uniprot id: A0A060HVH8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

926571:NVIE RS02895
gene id: 926571:NVIE_RS02895
uniprot id: A0A060HNL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

926571:NVIE RS04130
gene id: 926571:NVIE_RS04130
uniprot id: A0A060HPC7
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

926571:NVIE RS00440
gene id: 926571:NVIE_RS00440
uniprot id: A0A060HL06
names: Similarity
messages: Belongs to the TPP enzyme family.

926571:NVIE RS05185
gene id: 926571:NVIE_RS05185
uniprot id: A0A060HF83
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS06445
gene id: 926571:NVIE_RS06445
uniprot id: A0A060HJW6
names: Similarity
messages: Belongs to the HerA family.

926571:NVIE RS01730
gene id: 926571:NVIE_RS01730
uniprot id: A0A060HGS7
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

926571:NVIE RS04240
gene id: 926571:NVIE_RS04240
uniprot id: A0A060HIF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

926571:NVIE RS05910
gene id: 926571:NVIE_RS05910
uniprot id: A0A060HFS9
names: Similarity
messages: Belongs to the UPF0166 family.

926571:NVIE RS11695
gene id: 926571:NVIE_RS11695
uniprot id: A0A060HNG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS13045
gene id: 926571:NVIE_RS13045
uniprot id: A0A060HU99
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

926571:NVIE RS02225
gene id: 926571:NVIE_RS02225
uniprot id: A0A060HD38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

926571:NVIE RS13275
gene id: 926571:NVIE_RS13275
uniprot id: A0A060HNL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

926571:NVIE RS12950
gene id: 926571:NVIE_RS12950
uniprot id: A0A060HPC4
names: Similarity
messages: Belongs to the aspartokinase family.

926571:NVIE RS06800
gene id: 926571:NVIE_RS06800
uniprot id: A0A060HQ12
names: Subunit
messages: Homodimer.

926571:NVIE RS02825
gene id: 926571:NVIE_RS02825
uniprot id: A0A060HNJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

926571:NVIE RS08295
gene id: 926571:NVIE_RS08295
uniprot id: A0A060HL88
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

926571:NVIE RS09485
gene id: 926571:NVIE_RS09485
uniprot id: A0A060HM10
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS12170
gene id: 926571:NVIE_RS12170
uniprot id: A0A060HNV1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

926571:NVIE RS00110
gene id: 926571:NVIE_RS00110
uniprot id: A0A060HFP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

926571:NVIE RS08420
gene id: 926571:NVIE_RS08420
uniprot id: A0A060HS61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

926571:NVIE RS01305
gene id: 926571:NVIE_RS01305
uniprot id: A0A060HGK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

926571:NVIE RS01405
gene id: 926571:NVIE_RS01405
uniprot id: A0A060HFX3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

926571:NVIE RS00335
gene id: 926571:NVIE_RS00335
uniprot id: A0A060HFU5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

926571:NVIE RS05385
gene id: 926571:NVIE_RS05385
uniprot id: A0A060HFE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

926571:NVIE RS11410
gene id: 926571:NVIE_RS11410
uniprot id: A0A060HJ98
names: Similarity
messages: Belongs to the arsA ATPase family.

926571:NVIE RS01145
gene id: 926571:NVIE_RS01145
uniprot id: A0A060HGH1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS00340
gene id: 926571:NVIE_RS00340
uniprot id: A0A060HKY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

926571:NVIE RS07440
gene id: 926571:NVIE_RS07440
uniprot id: A0A060HQF6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

926571:NVIE RS02645
gene id: 926571:NVIE_RS02645
uniprot id: A0A060HDD1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS11050
gene id: 926571:NVIE_RS11050
uniprot id: A0A060HM63
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

926571:NVIE RS00185
gene id: 926571:NVIE_RS00185
uniprot id: A0A060HFR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

926571:NVIE RS13590
gene id: 926571:NVIE_RS13590
uniprot id: A0A060HPQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

926571:NVIE RS09085
gene id: 926571:NVIE_RS09085
uniprot id: A0A060HRG9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

926571:NVIE RS08105
gene id: 926571:NVIE_RS08105
uniprot id: A0A060HH77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

926571:NVIE RS12080
gene id: 926571:NVIE_RS12080
uniprot id: A0A060HUN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

926571:NVIE RS03805
gene id: 926571:NVIE_RS03805
uniprot id: A0A060HI78
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

926571:NVIE RS12050
gene id: 926571:NVIE_RS12050
uniprot id: A0A060HTK6
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

926571:NVIE RS02715
gene id: 926571:NVIE_RS02715
uniprot id: A0A060HGP1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS00510
gene id: 926571:NVIE_RS00510
uniprot id: A0A060HFY7
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS04115
gene id: 926571:NVIE_RS04115
uniprot id: A0A060HHM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

926571:NVIE RS14835
gene id: 926571:NVIE_RS14835
uniprot id: A0A060HLH1
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

926571:NVIE RS03100
gene id: 926571:NVIE_RS03100
uniprot id: A0A060HGZ6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

926571:NVIE RS04205
gene id: 926571:NVIE_RS04205
uniprot id: A0A060HHP4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

926571:NVIE RS03360
gene id: 926571:NVIE_RS03360
uniprot id: A0A060HI05
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

926571:NVIE RS10020
gene id: 926571:NVIE_RS10020
uniprot id: A0A060HT77
names: Similarity
messages: Belongs to the PstS family.

926571:NVIE RS01875
gene id: 926571:NVIE_RS01875
uniprot id: A0A060HCW4
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS02455
gene id: 926571:NVIE_RS02455
uniprot id: A0A060HGH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

926571:NVIE RS13965
gene id: 926571:NVIE_RS13965
uniprot id: A0A060HVX6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

926571:NVIE RS08425
gene id: 926571:NVIE_RS08425
uniprot id: A0A060HKJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

926571:NVIE RS02460
gene id: 926571:NVIE_RS02460
uniprot id: A0A060HD91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

926571:NVIE RS03910
gene id: 926571:NVIE_RS03910
uniprot id: A0A060HP91
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

926571:NVIE RS13680
gene id: 926571:NVIE_RS13680
uniprot id: A0A060HPS6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS13730
gene id: 926571:NVIE_RS13730
uniprot id: A0A060HPT9
names: Similarity
messages: Belongs to the Dps family.

926571:NVIE RS01285
gene id: 926571:NVIE_RS01285
uniprot id: A0A060HLK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

926571:NVIE RS06065
gene id: 926571:NVIE_RS06065
uniprot id: A0A060HJP6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

926571:NVIE RS10385
gene id: 926571:NVIE_RS10385
uniprot id: A0A060HMS4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

926571:NVIE RS00370
gene id: 926571:NVIE_RS00370
uniprot id: A0A060HM47
names: Similarity
messages: Belongs to the ALAD family.

926571:NVIE RS10055
gene id: 926571:NVIE_RS10055
uniprot id: A0A060HIG2
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS11255
gene id: 926571:NVIE_RS11255
uniprot id: A0A060HJ58
names: Similarity
messages: Belongs to the acylphosphatase family.

926571:NVIE RS14015
gene id: 926571:NVIE_RS14015
uniprot id: A0A060HNZ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

926571:NVIE RS06500
gene id: 926571:NVIE_RS06500
uniprot id: A0A060HPV1
names: Similarity
messages: Belongs to the pirin family.

926571:NVIE RS01155
gene id: 926571:NVIE_RS01155
uniprot id: A0A060HMM6
names: Similarity
messages: Belongs to the UPF0284 family.

926571:NVIE RS01825
gene id: 926571:NVIE_RS01825
uniprot id: A0A060HMY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

926571:NVIE RS01340
gene id: 926571:NVIE_RS01340
uniprot id: A0A060HMQ1
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

926571:NVIE RS03350
gene id: 926571:NVIE_RS03350
uniprot id: A0A060HP03
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

926571:NVIE RS06480
gene id: 926571:NVIE_RS06480
uniprot id: A0A060HQX6
names: Similarity
messages: Belongs to the MCM family.

926571:NVIE RS08470
gene id: 926571:NVIE_RS08470
uniprot id: A0A060HS70
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

926571:NVIE RS12335
gene id: 926571:NVIE_RS12335
uniprot id: A0A060HJZ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

926571:NVIE RS07135
gene id: 926571:NVIE_RS07135
uniprot id: A0A060HK87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

926571:NVIE RS06520
gene id: 926571:NVIE_RS06520
uniprot id: A0A060HJX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

926571:NVIE RS08545
gene id: 926571:NVIE_RS08545
uniprot id: A0A060HKL6
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS06565
gene id: 926571:NVIE_RS06565
uniprot id: A0A060HJ93
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

926571:NVIE RS07225
gene id: 926571:NVIE_RS07225
uniprot id: A0A060HGI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

926571:NVIE RS11045
gene id: 926571:NVIE_RS11045
uniprot id: A0A060HTY4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

926571:NVIE RS14080
gene id: 926571:NVIE_RS14080
uniprot id: A0A060HUX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

926571:NVIE RS07185
gene id: 926571:NVIE_RS07185
uniprot id: A0A060HKA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

926571:NVIE RS00065
gene id: 926571:NVIE_RS00065
uniprot id: A0A060HKT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

926571:NVIE RS11495
gene id: 926571:NVIE_RS11495
uniprot id: A0A060HU74
names: Function
names: Similarity
messages: Belongs to the GrpE family.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

926571:NVIE RS06020
gene id: 926571:NVIE_RS06020
uniprot id: A0A060HPK8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

926571:NVIE RS00125
gene id: 926571:NVIE_RS00125
uniprot id: A0A060HEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

926571:NVIE RS12990
gene id: 926571:NVIE_RS12990
uniprot id: A0A060HPD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

926571:NVIE RS13535
gene id: 926571:NVIE_RS13535
uniprot id: A0A060HNR0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

926571:NVIE RS14410
gene id: 926571:NVIE_RS14410
uniprot id: A0A060HP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

926571:NVIE RS09905
gene id: 926571:NVIE_RS09905
uniprot id: A0A060HS44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

926571:NVIE RS06730
gene id: 926571:NVIE_RS06730
uniprot id: A0A060HPZ7
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS00695
gene id: 926571:NVIE_RS00695
uniprot id: A0A060HG33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS07160
gene id: 926571:NVIE_RS07160
uniprot id: A0A060HK93
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.

926571:NVIE RS06315
gene id: 926571:NVIE_RS06315
uniprot id: A0A060HQU2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

926571:NVIE RS13600
gene id: 926571:NVIE_RS13600
uniprot id: A0A060HVP2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

926571:NVIE RS01550
gene id: 926571:NVIE_RS01550
uniprot id: A0A060HCQ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS03445
gene id: 926571:NVIE_RS03445
uniprot id: A0A060HHA6
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS00350
gene id: 926571:NVIE_RS00350
uniprot id: A0A060HF56
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

926571:NVIE RS07400
gene id: 926571:NVIE_RS07400
uniprot id: A0A060HQE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS11635
gene id: 926571:NVIE_RS11635
uniprot id: A0A060HMI0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

926571:NVIE RS05890
gene id: 926571:NVIE_RS05890
uniprot id: A0A060HPI9
names: Similarity
messages: Belongs to the UPF0166 family.

926571:NVIE RS07860
gene id: 926571:NVIE_RS07860
uniprot id: A0A060HKX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

926571:NVIE RS10515
gene id: 926571:NVIE_RS10515
uniprot id: A0A060HLW2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

926571:NVIE RS11700
gene id: 926571:NVIE_RS11700
uniprot id: A0A060HT99
names: Similarity
messages: Belongs to the PDCD5 family.

926571:NVIE RS06845
gene id: 926571:NVIE_RS06845
uniprot id: A0A060HQ21
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

926571:NVIE RS01720
gene id: 926571:NVIE_RS01720
uniprot id: A0A060HG26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

926571:NVIE RS02355
gene id: 926571:NVIE_RS02355
uniprot id: A0A060HH48
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS02450
gene id: 926571:NVIE_RS02450
uniprot id: A0A060HNA0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

926571:NVIE RS11650
gene id: 926571:NVIE_RS11650
uniprot id: A0A060HT85
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

926571:NVIE RS09090
gene id: 926571:NVIE_RS09090
uniprot id: A0A060HSI0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

926571:NVIE RS10945
gene id: 926571:NVIE_RS10945
uniprot id: A0A060HMZ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

926571:NVIE RS11185
gene id: 926571:NVIE_RS11185
uniprot id: A0A060HSY3
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

926571:NVIE RS02145
gene id: 926571:NVIE_RS02145
uniprot id: A0A060HN36
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

926571:NVIE RS08515
gene id: 926571:NVIE_RS08515
uniprot id: A0A060HS79
names: Similarity
messages: Belongs to the UPF0047 family.

926571:NVIE RS11415
gene id: 926571:NVIE_RS11415
uniprot id: A0A060HN92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

926571:NVIE RS10830
gene id: 926571:NVIE_RS10830
uniprot id: A0A060HIV8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS06820
gene id: 926571:NVIE_RS06820
uniprot id: A0A060HK23
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

926571:NVIE RS01535
gene id: 926571:NVIE_RS01535
uniprot id: A0A060HLP7
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

926571:NVIE RS06610
gene id: 926571:NVIE_RS06610
uniprot id: A0A060HQZ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS13655
gene id: 926571:NVIE_RS13655
uniprot id: A0A060HPR9
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

926571:NVIE RS11690
gene id: 926571:NVIE_RS11690
uniprot id: A0A060HJG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

926571:NVIE RS05295
gene id: 926571:NVIE_RS05295
uniprot id: A0A060HIG5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

926571:NVIE RS07275
gene id: 926571:NVIE_RS07275
uniprot id: A0A060HJP8
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

926571:NVIE RS08015
gene id: 926571:NVIE_RS08015
uniprot id: A0A060HQX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

926571:NVIE RS04945
gene id: 926571:NVIE_RS04945
uniprot id: A0A060HI72
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

926571:NVIE RS12320
gene id: 926571:NVIE_RS12320
uniprot id: A0A060HTS9
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

926571:NVIE RS02435
gene id: 926571:NVIE_RS02435
uniprot id: A0A060HD85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

926571:NVIE RS03110
gene id: 926571:NVIE_RS03110
uniprot id: A0A060HHP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

926571:NVIE RS04110
gene id: 926571:NVIE_RS04110
uniprot id: A0A060HPC3
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

926571:NVIE RS05920
gene id: 926571:NVIE_RS05920
uniprot id: A0A060HPJ2
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

926571:NVIE RS08435
gene id: 926571:NVIE_RS08435
uniprot id: A0A060HLA6
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

926571:NVIE RS07025
gene id: 926571:NVIE_RS07025
uniprot id: A0A060HQ59
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

926571:NVIE RS05335
gene id: 926571:NVIE_RS05335
uniprot id: A0A060HQ75
names: Similarity
messages: Belongs to the glutathione peroxidase family.

926571:NVIE RS04950
gene id: 926571:NVIE_RS04950
uniprot id: A0A060HF07
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

926571:NVIE RS02490
gene id: 926571:NVIE_RS02490
uniprot id: A0A060HH67
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

926571:NVIE RS08010
gene id: 926571:NVIE_RS08010
uniprot id: A0A060HL43
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

926571:NVIE RS04830
gene id: 926571:NVIE_RS04830
uniprot id: A0A060HIR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

926571:NVIE RS11510
gene id: 926571:NVIE_RS11510
uniprot id: A0A060HNB5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

926571:NVIE RS11470
gene id: 926571:NVIE_RS11470
uniprot id: A0A060HU69
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

926571:NVIE RS09025
gene id: 926571:NVIE_RS09025
uniprot id: A0A060HLL2
names: Similarity
messages: Belongs to the glutamine synthetase family.

926571:NVIE RS00115
gene id: 926571:NVIE_RS00115
uniprot id: A0A060HKU3
names: Similarity
messages: Belongs to the SDO1/SBDS family.

926571:NVIE RS12600
gene id: 926571:NVIE_RS12600
uniprot id: A0A060HU30
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

926571:NVIE RS00365
gene id: 926571:NVIE_RS00365
uniprot id: A0A060HKZ1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

926571:NVIE RS03705
gene id: 926571:NVIE_RS03705
uniprot id: A0A060HI62
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

926571:NVIE RS03380
gene id: 926571:NVIE_RS03380
uniprot id: A0A060HI10
names: Subcellular Location Annotation
messages: Cytoplasm

926571:NVIE RS00740
gene id: 926571:NVIE_RS00740
uniprot id: A0A060HG41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

926571:NVIE RS13135
gene id: 926571:NVIE_RS13135
uniprot id: A0A060HUB9
names: Similarity
messages: Belongs to the AHA1 family.

926571:NVIE RS06470
gene id: 926571:NVIE_RS06470
uniprot id: A0A060HJX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

926571:NVIE RS08930
gene id: 926571:NVIE_RS08930
uniprot id: A0A060HHL3
names: Similarity
messages: Belongs to the peptidase M1 family.

926571:NVIE RS03200
gene id: 926571:NVIE_RS03200
uniprot id: A0A060HHS0
names: Function
messages: Involved in the transposition of the insertion sequence.

926571:NVIE RS11425
gene id: 926571:NVIE_RS11425
uniprot id: A0A060HU60
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

926571:NVIE RS11290
gene id: 926571:NVIE_RS11290
uniprot id: A0A060HT08
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

926571:NVIE RS04570
gene id: 926571:NVIE_RS04570
uniprot id: A0A060HNL9
names: Subcellular Location Annotation
messages: Membrane

926571:NVIE RS14400
gene id: 926571:NVIE_RS14400
uniprot id: A0A060HV45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

926571:NVIE RS05705
gene id: 926571:NVIE_RS05705
uniprot id: A0A060HQJ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

926571:NVIE RS02870
gene id: 926571:NVIE_RS02870
uniprot id: A0A060HNK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

926571:NVIE RS12020
gene id: 926571:NVIE_RS12020
uniprot id: A0A060HNR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

926571:NVIE RS13855
gene id: 926571:NVIE_RS13855
uniprot id: A0A060HUS2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

926571:NVIE RS03670
gene id: 926571:NVIE_RS03670
uniprot id: A0A060HE87
names: Similarity
messages: Belongs to the DtxR/MntR family.

926571:NVIE RS07000
gene id: 926571:NVIE_RS07000
uniprot id: A0A060HQ54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

926571:NVIE RS10195
gene id: 926571:NVIE_RS10195
uniprot id: A0A060HIK2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

926571:NVIE RS06545
gene id: 926571:NVIE_RS06545
uniprot id: A0A060HJY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

926571:NVIE RS05775
gene id: 926571:NVIE_RS05775
uniprot id: A0A060HPG6
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

926571:NVIE RS05010
gene id: 926571:NVIE_RS05010
uniprot id: A0A060HI90
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

926571:NVIE RS05735
gene id: 926571:NVIE_RS05735
uniprot id: A0A060HIS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

926571:NVIE RS02835
gene id: 926571:NVIE_RS02835
uniprot id: A0A060HDI1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

926571:NVIE RS02550
gene id: 926571:NVIE_RS02550
uniprot id: A0A060HNC4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

926571:NVIE RS11220
gene id: 926571:NVIE_RS11220
uniprot id: A0A060HU17
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

926571:NVIE RS11275
gene id: 926571:NVIE_RS11275
uniprot id: A0A060HMA7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

926571:NVIE RS04125
gene id: 926571:NVIE_RS04125
uniprot id: A0A060HNC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

926571:NVIE RS01165
gene id: 926571:NVIE_RS01165
uniprot id: A0A060HCI1
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

926571:NVIE RS04265
gene id: 926571:NVIE_RS04265
uniprot id: A0A060HIF8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

926571:NVIE RS02855
gene id: 926571:NVIE_RS02855
uniprot id: A0A060HDI8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

926571:NVIE RS06615
gene id: 926571:NVIE_RS06615
uniprot id: A0A060HJA2
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

926571:NVIE RS02830
gene id: 926571:NVIE_RS02830
uniprot id: A0A060HGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm