9031:PMS2
gene id: 9031:PMS2
uniprot id: F1NQJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (By similarity).
messages: Nucleus

9031:TMEM178B
gene id: 9031:TMEM178B
uniprot id: R4GIP1
names: Similarity
messages: Belongs to the TMEM178 family.

9031:ODF2
gene id: 9031:ODF2
uniprot id: E1BSP2
uniprot id: Q5ZKK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODF2 family.
messages: Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail (By similarity).
messages: Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network (By similarity).
messages: centriole
messages: centrosome
messages: cilium
messages: flagellum
messages: spindle pole

9031:PDC
gene id: 9031:PDC
uniprot id: A0A1D5PA22
names: Similarity
messages: Belongs to the phosducin family.

9031:CENPQ
gene id: 9031:CENPQ
uniprot id: F1N9M3
uniprot id: Q1T764
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May play an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores.
messages: centromere

9031:ARVCF
gene id: 9031:ARVCF
uniprot id: A0A1D5PQC1
uniprot id: A0A3Q2U0X1
names: Similarity
messages: Belongs to the beta-catenin family.

9031:MFGE8
gene id: 9031:MFGE8
uniprot id: E1C0K5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PRR5
gene id: 9031:PRR5
uniprot id: E1C873
names: Similarity
messages: Belongs to the PROTOR family.

9031:SLC35C1
gene id: 9031:SLC35C1
uniprot id: E1BV92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

9031:VPS33A
gene id: 9031:VPS33A
uniprot id: A0A1L1RLU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9031:GPAM
gene id: 9031:GPAM
uniprot id: E1BTI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9031:TNFRSF19
gene id: 9031:TNFRSF19
uniprot id: A1XGV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PCYT1A
gene id: 9031:PCYT1A
uniprot id: A0A3Q3AGL8
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

9031:LOC100858069
gene id: 9031:LOC100858069
uniprot id: A0A3Q2UHU8
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:MAPKAP1
gene id: 9031:MAPKAP1
uniprot id: A0A3Q2U9J6
uniprot id: A0A3Q2UHQ6
uniprot id: Q9W6S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SIN1 family.
messages: Essential component of the TORC2 complex, which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).
messages: Part of the target of rapamycin 2 complex (TORC2).

9031:UBE2T
gene id: 9031:UBE2T
uniprot id: F1NM75
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:PPP1R3B
gene id: 9031:PPP1R3B
uniprot id: A0A1D5PQ59
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9031:DEGS1
gene id: 9031:DEGS1
uniprot id: Q5F3C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Expressed in retina and retinal pigment epithelium by Mueller cells (at protein level).
messages: Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity). Catalyzes the equilibrium isomerization of retinols (PubMed:23143414).
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.

9031:SIX1
gene id: 9031:SIX1
uniprot id: Q3C2H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

9031:CPLX3
gene id: 9031:CPLX3
uniprot id: A9DA55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9031:ACTR6
gene id: 9031:ACTR6
uniprot id: Q9DEE9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP6 subfamily.
messages: Expressed abundantly in the early developmental stages.
messages: Interacts with CBX1 and CBX3.
messages: Nucleus
messages: Required for formation and/or maintenance of the proper nucleolar structure and function (By similarity). Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription (PubMed:26164235). In the presence of high glucose, it maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z (PubMed:26164235).
messages: cytoskeleton
messages: nucleolus

9031:KRT14
gene id: 9031:KRT14
uniprot id: A0A1D5PZ89
uniprot id: Q6PVZ1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Expressed in epidermis.
messages: Heterotetramer of two type I and two type II keratins.
messages: Nucleus
messages: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

9031:POMK
gene id: 9031:POMK
uniprot id: Q5F349
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although related to the Ser/Thr protein kinase family, has no protein kinase activity and acts as a mannose kinase instead.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
messages: Endoplasmic reticulum membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif (By similarity).

9031:SERP1
gene id: 9031:SERP1
uniprot id: A0A1D5PAC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9031:LOC100858504
gene id: 9031:LOC100858504
uniprot id: H9L3N3
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:GIMAP6
gene id: 9031:GIMAP6
uniprot id: A0A1D5PDA8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9031:RECQL
gene id: 9031:RECQL
uniprot id: F1NPI7
uniprot id: Q8AYS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9031:DHX15
gene id: 9031:DHX15
uniprot id: Q5F3A9
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9031:NR2E1
gene id: 9031:NR2E1
uniprot id: Q91379
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Expressed exclusively in the neuroepithelium of the embryonic brain.
messages: Monomer.
messages: Nucleus
messages: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation (By similarity). Involved in the regulation of retinal development.

9031:COX11
gene id: 9031:COX11
uniprot id: A0A3Q2UL29
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9031:GNAI2
gene id: 9031:GNAI2
uniprot id: P50147
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (By similarity).
messages: centrosome

9031:CENPX
gene id: 9031:CENPX
uniprot id: A0A1D5PAJ6
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

9031:CCK
gene id: 9031:CCK
uniprot id: A0A023UDZ9
uniprot id: A0A1D5NVX6
uniprot id: Q9PU41
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the gastrin/cholecystokinin family.
messages: By dietary protein, amino acids and medium-chain triacylglycerol.
messages: In the small intestine, the major production site is around the vitelline diverticulum.
messages: Secreted
messages: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
messages: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.

9031:RBP5
gene id: 9031:RBP5
uniprot id: F1NAB5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:TNNC2
gene id: 9031:TNNC2
uniprot id: P02588
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the troponin C family.
messages: Skeletal muscle troponin C binds four calcium ions.
messages: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

9031:LOC769223
gene id: 9031:LOC769223
uniprot id: A0A1D5PMF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9031:LEPROTL1
gene id: 9031:LEPROTL1
uniprot id: A0A140T8I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9031:SLC6A18
gene id: 9031:SLC6A18
uniprot id: F1NPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:NXPH1
gene id: 9031:NXPH1
uniprot id: F1NQI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9031:LOC107057555
gene id: 9031:LOC107057555
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:GMPPA
gene id: 9031:GMPPA
uniprot id: F1NYN9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9031:PLRG1
gene id: 9031:PLRG1
uniprot id: A0A1L1RM96
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9031:IL8L2
gene id: 9031:IL8L2
uniprot id: A3DTN6
uniprot id: P08317
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: By serum. Expressed constitutively in Rous sarcoma virus (RSV) infected cells.
messages: Homodimer.
messages: May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils.
messages: Secreted

9031:DCLK2
gene id: 9031:DCLK2
uniprot id: A0A1D5P9G2
uniprot id: A0A1D5PKE8
uniprot id: A0A1D5PMG2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9031:ERP29
gene id: 9031:ERP29
uniprot id: P81628
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
messages: Endoplasmic reticulum lumen
messages: Homodimer.

9031:TNFSF10
gene id: 9031:TNFSF10
uniprot id: A0A1L1RSI0
uniprot id: Q5ZK93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

9031:PMEL
gene id: 9031:PMEL
uniprot id: Q98917
names: Developmental Stage
names: Function
names: PTM
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PMEL/NMB family.
messages: Expressed during the redifferentiation of pigmented epithelial cells (PEC).
messages: Glycosylated.
messages: Melanosome lumen
messages: Might be required for polymerization of melanin onto the core structure of melanosomes with enzymatic function of tyrosinase.
messages: Mutations in PMEL cause the Dominant white, Dun and Smoky plumage phenotypes in chicken. Both Dominant white and Dun inhibit the expression of black eumelanin giving rise to white plumage while Smoky gives a gray phenotype. The Dominant white phenotype is a breed characteristic of the White leghorn strain.
messages: Specific to pigmented epithelial cells and melanocytes. Not expressed in lens, neural retina, brain, heart, gizzard or liver.

9031:NDUFS4
gene id: 9031:NDUFS4
uniprot id: A0A1L1RM23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mitochondrion inner membrane

9031:ALG6
gene id: 9031:ALG6
uniprot id: A0A1L1RTX7
uniprot id: Q802T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:LOC428119
gene id: 9031:LOC428119
uniprot id: E1C3W3
names: Subcellular Location Annotation
messages: Membrane

9031:SLC6A14
gene id: 9031:SLC6A14
uniprot id: E1C8K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:SPIA9
gene id: 9031:SPIA9
uniprot id: A0A1L1RRQ8
names: Similarity
messages: Belongs to the serpin family.

9031:DGKG
gene id: 9031:DGKG
uniprot id: A0A3Q3AG99
uniprot id: F1N879
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9031:ALDH1A2
gene id: 9031:ALDH1A2
uniprot id: A0A1L1RMV7
uniprot id: O93344
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Converts retinaldehyde to retinoic acid. Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral.
messages: Cytoplasm
messages: Homotetramer.

9031:HN1
gene id: 9031:HN1
uniprot id: A0A1L1RUW4
uniprot id: Q5ZMA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9031:C11orf88
gene id: 9031:C11orf88
uniprot id: A0A1L1RYN4
names: Similarity
messages: Belongs to the HOATZ family.

9031:HDAC2
gene id: 9031:HDAC2
uniprot id: A0A1D5NW46
uniprot id: F1NM39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

9031:NEU3
gene id: 9031:NEU3
uniprot id: A0A1L1RZ60
uniprot id: I6LL52
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9031:C5orf24
gene id: 9031:C5orf24
uniprot id: E1BTZ0
names: Similarity
messages: Belongs to the UPF0461 family.

9031:CENPU
gene id: 9031:CENPU
uniprot id: Q2Z1W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-U/AME1 family.
messages: Interacts with CENPH-CENPI complex at the kinetochore.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for maintenance of sister chromatid adhesion during mitotic checkpoint activation.
messages: centromere

9031:USP5
gene id: 9031:USP5
uniprot id: E1C8W4
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:CHPF2
gene id: 9031:CHPF2
uniprot id: A0A1L1RW56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9031:METTL14
gene id: 9031:METTL14
uniprot id: Q5ZK35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of METTL3 and METTL14.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing.

9031:TAPT1
gene id: 9031:TAPT1
uniprot id: Q5ZLG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane
messages: Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 during development. May be involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells.
messages: centrosome
messages: cilium basal body

9031:RAD54L
gene id: 9031:RAD54L
uniprot id: O12944
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated. Acetylation promotes interaction with BRD9, and subsequently with RAD54, which is essential for homologous recombination (HR).
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Highly expressed in bursa, thymus, testis, and ovary. Low level of expression seen in all other organs tested.
messages: Homohexamer (By similarity). Interacts (via N-terminus) with RAD51 (By similarity). Interacts with NAP1L1 (By similarity). Interacts with BRD9; this interaction orchestrates RAD51-RAD54 complex formation (By similarity).
messages: Nucleus
messages: Phosphorylated. Phosphorylation at Ser-561 by NEK1 specifically in G2 phase allows efficient removal of RAD51 filaments from DNA.
messages: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Plays also an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA.

9031:TRPV2
gene id: 9031:TRPV2
uniprot id: A0A3Q2UCQ8
uniprot id: F1NPJ9
names: Subcellular Location Annotation
messages: Membrane

9031:OPA1
gene id: 9031:OPA1
uniprot id: A0A1D5PM27
uniprot id: Q5F499
uniprot id: R4GJ94
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity).
messages: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion membrane
messages: Oligomeric complex consisting of membrane-bound and soluble forms of OPA1. Binds PARL (By similarity).
messages: PARL-dependent proteolytic processing releases an antiapoptotic soluble form not required for mitochondrial fusion. Cleaved by OMA1 at position S1 following stress conditions.

9031:SLC25A14
gene id: 9031:SLC25A14
uniprot id: Q5ZJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:FAM98A
gene id: 9031:FAM98A
uniprot id: F1N9S3
uniprot id: Q5ZMB0
names: Similarity
messages: Belongs to the FAM98 family.

9031:LOC770794
gene id: 9031:LOC770794
uniprot id: A0A1D5PD52
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

9031:CLTB
gene id: 9031:CLTB
uniprot id: A0A1D5PJ40
uniprot id: A0A1D5PL88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9031:CYP2AB3
gene id: 9031:CYP2AB3
uniprot id: A0A1L1RXT4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:PRKAG1
gene id: 9031:PRKAG1
uniprot id: A0A1D5P8P6
uniprot id: A0A1D5PPC7
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.

9031:MDM1
gene id: 9031:MDM1
uniprot id: F1NH60
uniprot id: Q5ZMW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.
messages: Nucleus
messages: centriole
messages: centrosome

9031:RPL29
gene id: 9031:RPL29
uniprot id: A0A1L1RNZ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9031:GPLD1
gene id: 9031:GPLD1
uniprot id: A0A1D5PHH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

9031:TMEM35B
gene id: 9031:TMEM35B
uniprot id: E1C5T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

9031:SOD2
gene id: 9031:SOD2
uniprot id: Q9DDJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

9031:OVALY
gene id: 9031:OVALY
uniprot id: E1BTF4
uniprot id: I0J178
uniprot id: P01014
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Down-regulated by dietary stress. Decreased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens.
messages: Major protein of egg white (PubMed:25436390, PubMed:16428832). Expressed in the magnum of the oviduct (at protein level) (PubMed:25436390).
messages: N-glycosylated on at least two Asn residues by ovomucoid type carbohydrate units.
messages: Secreted
messages: The N-terminus is blocked.

9031:MAGI2
gene id: 9031:MAGI2
uniprot id: A0A3Q2UEI2
names: Subcellular Location Annotation
messages: Membrane

9031:SHKBP1
gene id: 9031:SHKBP1
uniprot id: E1C9F1
names: Similarity
messages: Belongs to the KCTD3 family.

9031:FUT8
gene id: 9031:FUT8
uniprot id: Q659W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

9031:HAS2
gene id: 9031:HAS2
uniprot id: A0A1D5NXM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

9031:FIBIN
gene id: 9031:FIBIN
uniprot id: E1BX99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9031:UPF3B
gene id: 9031:UPF3B
uniprot id: Q5ZHV0
names: Similarity
messages: Belongs to the RENT3 family.

9031:STK32A
gene id: 9031:STK32A
uniprot id: A0A1D5PEF0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:LDLRAD4
gene id: 9031:LDLRAD4
uniprot id: E1BYM2
uniprot id: F6RPR8
uniprot id: Q5ZJR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9031:PNAT3
gene id: 9031:PNAT3
uniprot id: P13914
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9031:CD151
gene id: 9031:CD151
uniprot id: Q5ZII8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:ROMO1
gene id: 9031:ROMO1
uniprot id: E1BRT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9031:LOC424109
gene id: 9031:LOC424109
uniprot id: F1NSB1
names: Similarity
messages: Belongs to the peptidase S51 family.

9031:SORL1
gene id: 9031:SORL1
uniprot id: E1BUD4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9031:UGCG
gene id: 9031:UGCG
uniprot id: E1C7A5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9031:PERPA
gene id: 9031:PERPA
uniprot id: R4GHP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9031:SGCB
gene id: 9031:SGCB
uniprot id: Q5ZJR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

9031:TAF11
gene id: 9031:TAF11
uniprot id: E1C6Y5
names: Similarity
messages: Belongs to the TAF11 family.

9031:HMMR
gene id: 9031:HMMR
uniprot id: A0A1D5P2N3
names: Subcellular Location Annotation
messages: spindle

9031:VCP
gene id: 9031:VCP
uniprot id: Q5ZMU9
names: Similarity
messages: Belongs to the AAA ATPase family.

9031:CREM
gene id: 9031:CREM
uniprot id: A0A1D5PT13
uniprot id: A0A3Q2U5F9
uniprot id: F1N847
names: Subcellular Location Annotation
messages: Nucleus

9031:TMEM192
gene id: 9031:TMEM192
uniprot id: A0A3Q2UAD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9031:ZDHHC15
gene id: 9031:ZDHHC15
uniprot id: F1NP33
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:RAB6A
gene id: 9031:RAB6A
uniprot id: Q1KME6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Golgi apparatus membrane
messages: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER.

9031:ELF2
gene id: 9031:ELF2
uniprot id: A0A1D5PQG4
uniprot id: E1C717
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:ATF2
gene id: 9031:ATF2
uniprot id: O93602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Heterodimerization is essential for its transcriptional activity (By similarity).
messages: Cytoplasm
messages: Mitochondrion outer membrane
messages: Nucleus
messages: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3') (By similarity).

9031:MGRN1
gene id: 9031:MGRN1
uniprot id: A0A1D5PJI2
uniprot id: A0A1D5PJN3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9031:CYCS
gene id: 9031:CYCS
uniprot id: P67881
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

9031:MARCH5
gene id: 9031:MARCH5
uniprot id: Q5ZJ41
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.
messages: Mitochondrion outer membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

9031:DSTN
gene id: 9031:DSTN
uniprot id: P18359
names: Function
names: Similarity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.

9031:PIGV
gene id: 9031:PIGV
uniprot id: A0A1D5PLM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9031:GPM6B
gene id: 9031:GPM6B
uniprot id: A0A1D5NYY1
uniprot id: A0A1D5P175
uniprot id: Q5EES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9031:LOC100858444
gene id: 9031:LOC100858444
uniprot id: A0A1D5PJ64
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:LOC107052810
gene id: 9031:LOC107052810
uniprot id: R4GLN9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:NCAM1
gene id: 9031:NCAM1
uniprot id: A0A1D5PQ40
names: Function
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

9031:PRDM6
gene id: 9031:PRDM6
uniprot id: F1NZV2
names: Subcellular Location Annotation
messages: Nucleus

9031:HACD2
gene id: 9031:HACD2
uniprot id: F6U467
uniprot id: Q5ZII7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:NRXN3
gene id: 9031:NRXN3
uniprot id: D0PRN3
uniprot id: D0PRN4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Brain and arteries (at protein level).
messages: Membrane
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion (By similarity). Plays a role in angiogenesis.
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity).
messages: Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides (By similarity).
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform 1b.

9031:WNT5B
gene id: 9031:WNT5B
uniprot id: F1NMK6
uniprot id: Q3L255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:PPP2CB
gene id: 9031:PPP2CB
uniprot id: P48463
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. May indirectly interact with SGOL1, most probably through regulatory B56 subunits (By similarity).
messages: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
messages: Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation (By similarity).
messages: Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).
messages: centromere
messages: spindle pole

9031:ATG12
gene id: 9031:ATG12
uniprot id: F1P145
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

9031:FUS
gene id: 9031:FUS
uniprot id: Q6J4Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9031:MFSD7
gene id: 9031:MFSD7
uniprot id: F1ND71
names: Subcellular Location Annotation
messages: Membrane

9031:ATP11C
gene id: 9031:ATP11C
uniprot id: A0A1D5NVY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:AOX1
gene id: 9031:AOX1
uniprot id: Q2QB50
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

9031:ACE2
gene id: 9031:ACE2
uniprot id: A0A5J6CU64
uniprot id: F1NHR4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

9031:ELAC2
gene id: 9031:ELAC2
uniprot id: F1P100
names: Similarity
messages: Belongs to the RNase Z family.

9031:GRK5
gene id: 9031:GRK5
uniprot id: E1BQG4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9031:NEUROD6
gene id: 9031:NEUROD6
uniprot id: A0A3Q2U1V3
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9031:RAB38
gene id: 9031:RAB38
uniprot id: R4GLM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9031:POLA1
gene id: 9031:POLA1
uniprot id: A0A3Q2TZM6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

9031:LOC430661
gene id: 9031:LOC430661
uniprot id: R4GIQ3
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:AKT1
gene id: 9031:AKT1
uniprot id: O57513
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9031:PPIP5K2
gene id: 9031:PPIP5K2
uniprot id: A0A1D5P1M9
uniprot id: A0A1D5PRG9
uniprot id: F1NQL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9031:UQCRHL
gene id: 9031:UQCRHL
uniprot id: F1NHW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9031:NCAPH
gene id: 9031:NCAPH
uniprot id: A0A1D5P3B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

9031:LIPT2
gene id: 9031:LIPT2
uniprot id: A0A3Q3A5Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9031:HMBS
gene id: 9031:HMBS
uniprot id: A0A1D5NZ54
names: Similarity
messages: Belongs to the HMBS family.

9031:AMOT
gene id: 9031:AMOT
uniprot id: E1C5Z2
names: Similarity
messages: Belongs to the angiomotin family.

9031:LIN28B
gene id: 9031:LIN28B
uniprot id: Q45KJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: Suppressor of specific microRNA (miRNA) biogenesis. Binds target primary miRNA transcripts and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. The specific interaction with target pri-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop.
messages: nucleolus

9031:SDAD1
gene id: 9031:SDAD1
uniprot id: A0A3Q2U7P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9031:SNTB1
gene id: 9031:SNTB1
uniprot id: Q5ZKZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

9031:OR1052
gene id: 9031:OR1052
uniprot id: F1NT41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:ASCC3
gene id: 9031:ASCC3
uniprot id: F1NTD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes.
messages: Belongs to the helicase family.
messages: Nucleus
messages: Nucleus speckle
messages: cytosol

9031:IL17RD
gene id: 9031:IL17RD
uniprot id: Q7T2L7
names: Function
names: Subcellular Location Annotation
messages: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
messages: Membrane

9031:CUBN
gene id: 9031:CUBN
uniprot id: F1NIW7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9031:PCK1
gene id: 9031:PCK1
uniprot id: P05153
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one.
messages: Monomer.
messages: Phosphoenolpyruvate carboxykinase activity is regulated by glucose levels (By similarity). Phosphorylation at Ser-90 reduces the binding affinity to oxaloacetate and converts the enzyme into an atypical protein kinase using GTP as donor (By similarity).
messages: Phosphorylation at Ser-90 reduces the binding affinity to oxaloacetate and promotes the protein kinase activity.
messages: Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor.

9031:UGT2A1
gene id: 9031:UGT2A1
uniprot id: F1NMB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9031:CHUK
gene id: 9031:CHUK
uniprot id: A0A1D5PFM2
uniprot id: Q5ZJB4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated when phosphorylated and inactivated when dephosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

9031:ABAT
gene id: 9031:ABAT
uniprot id: E1C8M8
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

9031:NPBWR2
gene id: 9031:NPBWR2
uniprot id: A0A172PX08
uniprot id: A0A3Q2UEP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SLC1A4
gene id: 9031:SLC1A4
uniprot id: E1BRV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9031:N4BP3
gene id: 9031:N4BP3
uniprot id: Q5ZLT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage.
messages: axon
messages: dendrite

9031:WNT7A
gene id: 9031:WNT7A
uniprot id: Q9DEB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:PHKB
gene id: 9031:PHKB
uniprot id: Q5ZME3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9031:RPLP2
gene id: 9031:RPLP2
uniprot id: A0A1D5PMT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9031:ARF4
gene id: 9031:ARF4
uniprot id: Q5ZKR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9031:GPR89A
gene id: 9031:GPR89A
uniprot id: Q5F448
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Golgi apparatus membrane
messages: Homotrimer.
messages: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (By similarity). Plays a role in lymphocyte development (By similarity).

9031:RPAIN
gene id: 9031:RPAIN
uniprot id: F1NV56
names: Subcellular Location Annotation
messages: Nucleus

9031:MTHFR
gene id: 9031:MTHFR
uniprot id: E1BXL1
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

9031:CNRIP1
gene id: 9031:CNRIP1
uniprot id: E1BU35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9031:AHCYL1
gene id: 9031:AHCYL1
uniprot id: Q5F3Q3
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9031:GFRA1
gene id: 9031:GFRA1
uniprot id: O13156
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).

9031:VPS8
gene id: 9031:VPS8
uniprot id: A0A3Q3B0E7
names: Similarity
messages: Belongs to the VPS8 family.

9031:NOX4
gene id: 9031:NOX4
uniprot id: A0A3Q2TYG2
uniprot id: A7E3L2
names: Subcellular Location Annotation
messages: Membrane

9031:SEC24C
gene id: 9031:SEC24C
uniprot id: A0A3Q2UGR5
uniprot id: E1BUD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9031:CHAF1A
gene id: 9031:CHAF1A
uniprot id: A0A1L1RN36
uniprot id: Q5R1T0
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHAF1A family.
messages: Cells lacking CHAF1A show delayed S-phase progression with retarded DNA synthesis and defects in a rapid nucleosome formation of newly replicated DNA.
messages: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
messages: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains.
messages: Nucleus
messages: Subunit of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. Interacts with CHAF1B, PCNA and RBBP4 (PubMed:17065558).

9031:SMC1B
gene id: 9031:SMC1B
uniprot id: F1NX72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

9031:CYB5R1
gene id: 9031:CYB5R1
uniprot id: F1NZY9
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9031:B3GAT1L
gene id: 9031:B3GAT1L
uniprot id: F1NQ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:GABARAPL1
gene id: 9031:GABARAPL1
uniprot id: E1C2J6
names: Similarity
messages: Belongs to the ATG8 family.

9031:CDK18
gene id: 9031:CDK18
uniprot id: E1C3N0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:STEAP3
gene id: 9031:STEAP3
uniprot id: A0A1D5P106
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9031:RXRG
gene id: 9031:RXRG
uniprot id: P28701
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At stage 16, in the posterior trunk region, expressed in the neural crest and in neural crest cells migrating into the sclerotome. From stages 24 to 27, expressed in the liver and in elements of the developing peripheral nervous system derived from the neural crest, including dorsal root ganglia, cranial ganglia, enteric ganglia and peripheral nerve tracts.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.
messages: Isoform 1 is highly expressed inliver. Isoform 2 is abundantly expressed in eye and dorsal root ganglia.
messages: Nucleus
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

9031:SHOX
gene id: 9031:SHOX
uniprot id: Q00G66
names: Subcellular Location Annotation
messages: Nucleus

9031:WASF2
gene id: 9031:WASF2
uniprot id: H9L0D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9031:PCBD2
gene id: 9031:PCBD2
uniprot id: Q9DG45
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
messages: Highest level found in the kidney, liver, heart and ovarian follicles.
messages: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).
messages: Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.

9031:SMO
gene id: 9031:SMO
uniprot id: A0A1D5P8D7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:RPGRIP1L
gene id: 9031:RPGRIP1L
uniprot id: A0A3Q2TTF0
uniprot id: A0A3Q2U526
names: Similarity
messages: Belongs to the RPGRIP1 family.

9031:IK
gene id: 9031:IK
uniprot id: Q5ZHM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9031:TSPAN12
gene id: 9031:TSPAN12
uniprot id: Q5ZIF5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP).
messages: Palmitoylated; required for interaction with ADAM10. The precise position of palmitoylated residues is unclear and occurs either on Cys-9, Cys-12 and/or Cys-83 (By similarity).
messages: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity).

9031:VTG1
gene id: 9031:VTG1
uniprot id: P87498
names: Allergen
names: Function
names: Induction
names: PTM
names: Tissue Specificity
messages: By steroids (estrogen).
messages: Cathepsin D is responsible for intraoocytic processing of vitellogenin.
messages: Causes an allergic reaction in human (PubMed:26897338). Binds to IgE (PubMed:20509661, PubMed:26897338).
messages: May contain intrachain disulfide bonds.
messages: Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo.
messages: Phosvitin, an egg yolk storage protein, is one of the most highly phosphorylated (10%) proteins in nature.
messages: Precursor of the egg-yolk proteins that are sources of nutrients during early development of oviparous organisms.
messages: Produced by the liver, secreted into the blood and then sequestered by receptor mediated endocytosis into growing oocytes, where it is generally cleaved, giving rise to the respective yolk components.

9031:ETV6
gene id: 9031:ETV6
uniprot id: F1NRC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:LOC107053306
gene id: 9031:LOC107053306
uniprot id: A0A1L1RRL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:SERINC3
gene id: 9031:SERINC3
uniprot id: Q5ZJ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9031:SLC45A4
gene id: 9031:SLC45A4
uniprot id: A0A1D5NU91
names: Subcellular Location Annotation
messages: Membrane

9031:HNF1B
gene id: 9031:HNF1B
uniprot id: E1C4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9031:USP9Y
gene id: 9031:USP9Y
uniprot id: E1BWJ5
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:DUOXA1L
gene id: 9031:DUOXA1L
uniprot id: A0A1D5PDQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

9031:KRT23
gene id: 9031:KRT23
uniprot id: A0A1D5PQ65
names: Similarity
messages: Belongs to the intermediate filament family.

9031:SWAP70
gene id: 9031:SWAP70
uniprot id: Q5F4B2
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
messages: The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
messages: The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70.
messages: Tyrosine-phosphorylated.
messages: lamellipodium

9031:PARG
gene id: 9031:PARG
uniprot id: F1NY76
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

9031:ATP6V1B2
gene id: 9031:ATP6V1B2
uniprot id: A0A1D5PP57
uniprot id: Q9I8A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9031:MAPK8
gene id: 9031:MAPK8
uniprot id: A0A3Q2TY19
uniprot id: E1C1H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9031:CARTPT
gene id: 9031:CARTPT
uniprot id: M4M7V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9031:TSHZ3
gene id: 9031:TSHZ3
uniprot id: F1NMF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9031:PCDHA5
gene id: 9031:PCDHA5
uniprot id: Q6R0I6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:DTL
gene id: 9031:DTL
uniprot id: Q5ZJW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat cdt2 family.
messages: Chromosome
messages: Component of the DCX(DTL) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DTL/CDT2 and RBX1.
messages: Nucleus
messages: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity). May play a role in the regulation of the circadian clock (By similarity).
messages: centrosome

9031:GPR37L1
gene id: 9031:GPR37L1
uniprot id: F1NJ18
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TTC3
gene id: 9031:TTC3
uniprot id: F1P0T0
names: Subcellular Location Annotation
messages: Cytoplasm

9031:OTOP2
gene id: 9031:OTOP2
uniprot id: F1NP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9031:HDAC4
gene id: 9031:HDAC4
uniprot id: P83038
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).

9031:IFT20
gene id: 9031:IFT20
uniprot id: A0A1L1RUE2
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

9031:GOLPH3
gene id: 9031:GOLPH3
uniprot id: R4GJZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9031:ERCC5
gene id: 9031:ERCC5
uniprot id: F1P266
uniprot id: Q4AEJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

9031:LIMD1
gene id: 9031:LIMD1
uniprot id: A0A1D5PYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Nucleus

9031:LOC428778
gene id: 9031:LOC428778
uniprot id: A0A3Q2U6B9
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.

9031:MCM6
gene id: 9031:MCM6
uniprot id: Q5ZKR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

9031:BOLA3
gene id: 9031:BOLA3
uniprot id: A0A3Q3A7C9
names: Similarity
messages: Belongs to the BolA/IbaG family.

9031:SCN5A
gene id: 9031:SCN5A
uniprot id: F1N8I1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9031:SPP2
gene id: 9031:SPP2
uniprot id: F1P4U3
uniprot id: Q91982
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

9031:GPBP1
gene id: 9031:GPBP1
uniprot id: E1C106
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

9031:MED30
gene id: 9031:MED30
uniprot id: A0A1D5NUC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9031:AP2M1
gene id: 9031:AP2M1
uniprot id: Q5ZMP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids.
messages: coated pit

9031:ARL14
gene id: 9031:ARL14
uniprot id: A0A1D5P0L5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9031:RAP1B
gene id: 9031:RAP1B
uniprot id: Q5ZHX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell junction
messages: Cell membrane
messages: Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity).
messages: cytosol

9031:LOC422214
gene id: 9031:LOC422214
uniprot id: Q5ZKR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By simi…
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA.
messages: Cytoplasm
messages: Nucleus

9031:WISP1
gene id: 9031:WISP1
uniprot id: Q4ZJF1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:MMGT1
gene id: 9031:MMGT1
uniprot id: R4GI67
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

9031:CHRNA5
gene id: 9031:CHRNA5
uniprot id: P26152
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
messages: Cell membrane
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
messages: Postsynaptic cell membrane

9031:SLC1A2
gene id: 9031:SLC1A2
uniprot id: Q5ZJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9031:NUDT5
gene id: 9031:NUDT5
uniprot id: E1BW57
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9031:LOC408038
gene id: 9031:LOC408038
uniprot id: R4GG12
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:MTG1
gene id: 9031:MTG1
uniprot id: E1C7T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Mitochondrion inner membrane
messages: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

9031:MIEF2
gene id: 9031:MIEF2
uniprot id: F1P228
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9031:APAF1
gene id: 9031:APAF1
uniprot id: F1P1P3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

9031:KCNK2
gene id: 9031:KCNK2
uniprot id: F1NZ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9031:RNH1
gene id: 9031:RNH1
uniprot id: Q5ZIY8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9031:FAM161A
gene id: 9031:FAM161A
uniprot id: E1BRV7
names: Similarity
messages: Belongs to the FAM161 family.

9031:NGFR
gene id: 9031:NGFR
uniprot id: A9UGK7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ANAPC13
gene id: 9031:ANAPC13
uniprot id: A0A1D5PVV7
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

9031:MIER1
gene id: 9031:MIER1
uniprot id: Q5ZKT9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor regulating the expression of a number of genes. Probably functions through recruitment of histone deacetylases involved in chromatin silencing (By similarity).

9031:BRCA1
gene id: 9031:BRCA1
uniprot id: Q90Z51
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

9031:LBH
gene id: 9031:LBH
uniprot id: Q5ZM46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional activator.

9031:TFRC
gene id: 9031:TFRC
uniprot id: Q90997
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity).
messages: Homodimer; disulfide-linked. Binds one transferrin molecule per subunit (By similarity).
messages: Melanosome
messages: N- and O-glycosylated, phosphorylated and palmitoylated.
messages: Stearoylated (By similarity). Stearoylation does not affect iron uptake (By similarity).

9031:NPBWR1
gene id: 9031:NPBWR1
uniprot id: A0A172PWX5
uniprot id: E1C327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:LTA4H
gene id: 9031:LTA4H
uniprot id: Q5ZJJ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9031:ESR2
gene id: 9031:ESR2
uniprot id: Q9PTU5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-alpha.
messages: Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nucleus

9031:SERPINH1
gene id: 9031:SERPINH1
uniprot id: P13731
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
messages: By heat shock.
messages: Endoplasmic reticulum lumen

9031:NMRAL1
gene id: 9031:NMRAL1
uniprot id: Q5ZID0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NmrA-type oxidoreductase family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks the conserved Tyr residue in the active site triad of Ser-Tyr-Lys necessary for dehydrogenase activity, suggesting that it has no oxidoreductase activity.
messages: Nucleus
messages: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels (By similarity).
messages: perinuclear region

9031:DYNC1LI2
gene id: 9031:DYNC1LI2
uniprot id: Q5ZMQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9031:NDUFA1
gene id: 9031:NDUFA1
uniprot id: E1BQ44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Mitochondrion inner membrane

9031:HSPA2
gene id: 9031:HSPA2
uniprot id: A0A346RQZ3
uniprot id: P08106
names: Domain
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
messages: The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.

9031:EXOC1
gene id: 9031:EXOC1
uniprot id: A0A1D5P158
uniprot id: A0A1D5P782
uniprot id: E1BS87
names: Similarity
messages: Belongs to the SEC3 family.

9031:MBTPS1
gene id: 9031:MBTPS1
uniprot id: E1C6Y2
names: Similarity
messages: Belongs to the peptidase S8 family.

9031:BMP2
gene id: 9031:BMP2
uniprot id: A0A1D5P3H4
uniprot id: Q6XDQ0
names: Similarity
messages: Belongs to the TGF-beta family.

9031:GNOT2
gene id: 9031:GNOT2
uniprot id: Q98911
names: Subcellular Location Annotation
messages: Nucleus

9031:GSX1
gene id: 9031:GSX1
uniprot id: A0A1D5PL43
names: Subcellular Location Annotation
messages: Nucleus

9031:MBOAT2
gene id: 9031:MBOAT2
uniprot id: Q5ZKL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. May catalyze preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Prefers oleoyl-CoA as the acyl donor.
messages: Belongs to the membrane-bound acyltransferase family.
messages: Endoplasmic reticulum
messages: Membrane

9031:AGPAT3
gene id: 9031:AGPAT3
uniprot id: A0A1D5PUB7
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:AK3
gene id: 9031:AK3
uniprot id: A0A1D5PHA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9031:CCND1
gene id: 9031:CCND1
uniprot id: P55169
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex (By similarity). The cyclin subunit imparts substrate specificity to the complex (By similarity).
messages: Nucleus
messages: Phosphorylation at Thr-283 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex.
messages: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
messages: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation. The DCX(AMBRA1) complex represents the major regulator of CCND1 stability during the G1/S transition.

9031:ABHD3
gene id: 9031:ABHD3
uniprot id: F1NTP8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9031:OTX1
gene id: 9031:OTX1
uniprot id: R4GG58
names: Subcellular Location Annotation
messages: Nucleus

9031:MALSU1
gene id: 9031:MALSU1
uniprot id: F1NPS2
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9031:LOC100857191
gene id: 9031:LOC100857191
uniprot id: A0A3Q2U125
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:DDC
gene id: 9031:DDC
uniprot id: E1BV90
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9031:VTI1B
gene id: 9031:VTI1B
uniprot id: E1BUX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9031:MFSD11
gene id: 9031:MFSD11
uniprot id: E1BSA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9031:HMGB1
gene id: 9031:HMGB1
uniprot id: Q9YH06
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome
messages: Cytoplasm
messages: Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucleic acids. May promote inflammatory response to sterile and infectious signals and may be involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm may function as sensor and/or chaperone for immunogenic nucleic acids, and mediate autophagy. May act as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury.
messages: Nucleus
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities: 1- fully reduced HMGB1 (HMGB1C23hC45hC106h), 2- disulfide HMGB1 (HMGB1C23-C45C106h) and 3- sulfonyl HMGB1 (HMGB1C23soC45soC106so).
messages: Secreted
messages: The acidic C-terminal domain forms a flexible structure which can reversibly interact intramolecularily with the HMG boxes and modulate binding to DNA and other proteins; may involve Lys-3 and histone H3 'Lys-37' and 'Lys-38'.

9031:PFKFB2
gene id: 9031:PFKFB2
uniprot id: E1BXR3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9031:PAX9
gene id: 9031:PAX9
uniprot id: F1N8W6
names: Subcellular Location Annotation
messages: Nucleus

9031:PICK1
gene id: 9031:PICK1
uniprot id: A0A1D5P5B8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9031:NIFK
gene id: 9031:NIFK
uniprot id: F1NT45
names: Subcellular Location Annotation
messages: nucleolus

9031:CFH
gene id: 9031:CFH
uniprot id: A0A3Q2TRY3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CA3B
gene id: 9031:CA3B
uniprot id: A0A1D5P5F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9031:YWHAG
gene id: 9031:YWHAG
uniprot id: Q5F3W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.

9031:MYH7B
gene id: 9031:MYH7B
uniprot id: Q8UWA0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:SLC35C2
gene id: 9031:SLC35C2
uniprot id: Q5ZJ63
names: Subcellular Location Annotation
messages: Membrane

9031:SS18
gene id: 9031:SS18
uniprot id: A0A1D5PX83
uniprot id: Q5ZMA8
names: Similarity
messages: Belongs to the SS18 family.

9031:WDR1
gene id: 9031:WDR1
uniprot id: O93277
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat AIP1 family.
messages: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity).
messages: cytoskeleton

9031:CHMP3
gene id: 9031:CHMP3
uniprot id: E1C230
names: Similarity
messages: Belongs to the SNF7 family.

9031:TOE1
gene id: 9031:TOE1
uniprot id: F1N9P8
names: Similarity
messages: Belongs to the CAF1 family.

9031:FTO
gene id: 9031:FTO
uniprot id: D7REI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Cytoplasm
messages: Nucleus speckle

9031:FAM212B
gene id: 9031:FAM212B
uniprot id: E1BU53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

9031:NKD1
gene id: 9031:NKD1
uniprot id: A0A1D5PR14
uniprot id: A0A3Q2TWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9031:TIMM9
gene id: 9031:TIMM9
uniprot id: Q5ZIR8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

9031:DCP1A
gene id: 9031:DCP1A
uniprot id: A0A1D5PQ74
names: Similarity
messages: Belongs to the DCP1 family.

9031:NR3C2
gene id: 9031:NR3C2
uniprot id: A0A3Q2U9S3
uniprot id: C1KB84
names: Subcellular Location Annotation
messages: Nucleus

9031:LOC107052803
gene id: 9031:LOC107052803
uniprot id: A0A1D5P312
uniprot id: A0A1D5P6V7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:GEMIN2
gene id: 9031:GEMIN2
uniprot id: Q5ZJH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

9031:PEMT
gene id: 9031:PEMT
uniprot id: Q5ZJB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9031:PLA2G2E
gene id: 9031:PLA2G2E
uniprot id: D6NKG5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9031:FYTTD1L
gene id: 9031:FYTTD1L
uniprot id: A0A1D5PLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

9031:SOX1
gene id: 9031:SOX1
uniprot id: O57401
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation.

9031:CDX1
gene id: 9031:CDX1
uniprot id: Q9DEB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus
messages: Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.

9031:VEZT
gene id: 9031:VEZT
uniprot id: F1P4W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

9031:TSPAN7
gene id: 9031:TSPAN7
uniprot id: F1NUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:NUDT12
gene id: 9031:NUDT12
uniprot id: E1C2E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

9031:TMEM120B
gene id: 9031:TMEM120B
uniprot id: A0A3Q2UHS0
uniprot id: Q5ZJN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9031:BAMBI
gene id: 9031:BAMBI
uniprot id: E1AWU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9031:NOX5
gene id: 9031:NOX5
uniprot id: A0A1D5P1N8
names: Subcellular Location Annotation
messages: Membrane

9031:AARS1
gene id: 9031:AARS1
uniprot id: F1P5J5
uniprot id: Q5ZKF3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9031:NUMB
gene id: 9031:NUMB
uniprot id: A0A1D5NU12
uniprot id: Q9PW30
names: Function
messages: Plays a role in the process of neurogenesis.

9031:TBCA
gene id: 9031:TBCA
uniprot id: F1NVH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9031:LOC426385
gene id: 9031:LOC426385
uniprot id: Q5ZJE9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:LRP4
gene id: 9031:LRP4
uniprot id: A0A1D5PKF3
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:RPS7
gene id: 9031:RPS7
uniprot id: F1NN16
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

9031:SUGT1
gene id: 9031:SUGT1
uniprot id: F1NAS0
names: Similarity
messages: Belongs to the SGT1 family.

9031:GPRIN3
gene id: 9031:GPRIN3
uniprot id: R4GH95
names: Function
messages: May be involved in neurite outgrowth.

9031:NKX3-2
gene id: 9031:NKX3-2
uniprot id: Q98TG7
names: Subcellular Location Annotation
messages: Nucleus

9031:VDR
gene id: 9031:VDR
uniprot id: O42392
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Expressed in kidney and intestine.
messages: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding.
messages: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9031:NPVF
gene id: 9031:NPVF
uniprot id: Q75XU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

9031:LTBP1
gene id: 9031:LTBP1
uniprot id: A0A3Q3AKA0
uniprot id: F1N9I4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:SNCG
gene id: 9031:SNCG
uniprot id: Q9I9H0
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

9031:KATNA1
gene id: 9031:KATNA1
uniprot id: A0A3Q2UDW1
uniprot id: Q1HGK7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: Cytoplasm
messages: centrosome
messages: spindle
messages: spindle pole

9031:SLC15A4
gene id: 9031:SLC15A4
uniprot id: F1NG54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

9031:ATP5F1AZ
gene id: 9031:ATP5F1AZ
uniprot id: Q8UVX3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9031:BDNF
gene id: 9031:BDNF
uniprot id: A0A3Q2UCU5
uniprot id: K4MNE5
uniprot id: P25429
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity).
messages: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
messages: Secreted

9031:WDR4
gene id: 9031:WDR4
uniprot id: A0A1L1RYV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit METTL1.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

9031:SLC31A1
gene id: 9031:SLC31A1
uniprot id: A0A1D5PYH2
uniprot id: F1NNU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

9031:PKD2L2
gene id: 9031:PKD2L2
uniprot id: F1NE51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

9031:SLC6A2
gene id: 9031:SLC6A2
uniprot id: A0A1D5P472
uniprot id: Q9DGN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:ATP2A2
gene id: 9031:ATP2A2
uniprot id: A0A1L1RKB7
uniprot id: Q03669
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Ca(2+) and ATP binding cause major rearrangements of the cytoplasmic and transmembrane domains. According to the E1-E2 model, Ca(2+) binding to the cytosolic domain of the pump in the high-affinity E1 conformation is followed by the ATP-dependent phosphorylation of the active site Asp, giving rise to E1P. A conformational change of the phosphoenzyme gives rise to the low-affinity E2P state that exposes the Ca(2+) ions to the lumenal side and promotes Ca(2+) release. Dephosphorylation of the active site Asp mediates the subsequent return to the E1 conformation.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity). Interacts with TMX2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Only isoform 2 is detected in heart, while both isoforms are expressed in brain, with isoform 2 being predominant.
messages: PLN and SLN both have a single transmembrane helix; both occupy a similar binding site that is situated between the ATP2A2 transmembrane helices.
messages: Reversibly inhibited by phospholamban (PLN) at low calcium concentrations (By similarity). Inhibited by sarcolipin (SLN) and myoregulin (MRLN) (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. May act as a regulator of TNFSF11-mediated Ca(2+) signaling during osteoclastogenesis.

9031:MRPS30
gene id: 9031:MRPS30
uniprot id: O42270
names: Subcellular Location Annotation
messages: Mitochondrion

9031:GATA2
gene id: 9031:GATA2
uniprot id: P23824
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in all developmental stages of erythroid cells but is additionally found in a limited subset of other tissues.
messages: Nucleus
messages: Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.

9031:DLX3
gene id: 9031:DLX3
uniprot id: Q9PT89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9031:NSUN5
gene id: 9031:NSUN5
uniprot id: E1C5I8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9031:SRSF5
gene id: 9031:SRSF5
uniprot id: E1BY00
names: Similarity
messages: Belongs to the splicing factor SR family.

9031:QRFPR
gene id: 9031:QRFPR
uniprot id: B2CL09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:TAMM41
gene id: 9031:TAMM41
uniprot id: E1BUW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9031:TNN
gene id: 9031:TNN
uniprot id: A0A3Q2UEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9031:COL4A3BP
gene id: 9031:COL4A3BP
uniprot id: A0A1D5P5T9
uniprot id: A0A1D5PC51
uniprot id: E1C409
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

9031:RALA
gene id: 9031:RALA
uniprot id: A0A1D5P1T0
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9031:IDS
gene id: 9031:IDS
uniprot id: A0A1L1RU31
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:MYH1A
gene id: 9031:MYH1A
uniprot id: Q8AY28
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:PDCL
gene id: 9031:PDCL
uniprot id: E1BQM7
names: Similarity
messages: Belongs to the phosducin family.

9031:UTP3
gene id: 9031:UTP3
uniprot id: A0A3Q2U489
names: Similarity
messages: Belongs to the SAS10 family.

9031:WWOX
gene id: 9031:WWOX
uniprot id: Q5F389
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Nucleus
messages: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity).

9031:GYS2
gene id: 9031:GYS2
uniprot id: E1BXK3
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

9031:RPL37
gene id: 9031:RPL37
uniprot id: E1C810
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9031:L3HYPDH
gene id: 9031:L3HYPDH
uniprot id: E1BSN3
names: Similarity
messages: Belongs to the proline racemase family.

9031:PCSK5
gene id: 9031:PCSK5
uniprot id: A0A1D5NXR1
uniprot id: F1NU61
names: Similarity
messages: Belongs to the peptidase S8 family.

9031:SUCLA2
gene id: 9031:SUCLA2
uniprot id: Q5F3B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9031:LOC101749502
gene id: 9031:LOC101749502
uniprot id: A0A1L1S0V0
names: Subcellular Location Annotation
messages: Secreted

9031:ACTA2
gene id: 9031:ACTA2
uniprot id: F1P476
uniprot id: P08023
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:ARFGEF2
gene id: 9031:ARFGEF2
uniprot id: E1BVQ3
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9031:GBP4L
gene id: 9031:GBP4L
uniprot id: A0A1D5P4F3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9031:TRPC1
gene id: 9031:TRPC1
uniprot id: Q6DMS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

9031:CRYAB
gene id: 9031:CRYAB
uniprot id: Q05713
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Heteromer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens.
messages: Lens as well as other tissues.
messages: May contribute to the transparency and refractive index of the lens.

9031:CNGA3
gene id: 9031:CNGA3
uniprot id: Q90805
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
messages: Membrane
messages: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors.

9031:MRPL9
gene id: 9031:MRPL9
uniprot id: A0A1D5PRM3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

9031:NTHL1
gene id: 9031:NTHL1
uniprot id: A7M7B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Mitochondrion
messages: Nucleus

9031:TUBA8A
gene id: 9031:TUBA8A
uniprot id: A0A1D5P5Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:MYH7
gene id: 9031:MYH7
uniprot id: Q910C5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:EIF4G1
gene id: 9031:EIF4G1
uniprot id: A0A1D5P490
uniprot id: A0A1D5P6I5
uniprot id: A0A1D5PPZ0
uniprot id: E1BSG5
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9031:PDSS1
gene id: 9031:PDSS1
uniprot id: E1BZW8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9031:NPY4R
gene id: 9031:NPY4R
uniprot id: Q8QGM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:LCLAT1
gene id: 9031:LCLAT1
uniprot id: Q5F3X0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (By similarity). Required for establishment of the hematopoietic and endothelial lineages (By similarity).
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9031:PVALB
gene id: 9031:PVALB
uniprot id: C1L370
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

9031:DENND5B
gene id: 9031:DENND5B
uniprot id: A0A1L1RPK6
uniprot id: A0A3S5ZPX0
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CLCN6
gene id: 9031:CLCN6
uniprot id: E1BZI1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SRP19
gene id: 9031:SRP19
uniprot id: F1NQ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9031:RPL23
gene id: 9031:RPL23
uniprot id: E1BY89
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

9031:PRKCB
gene id: 9031:PRKCB
uniprot id: A0A1D5PCZ1
uniprot id: A0A1D5PUY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9031:PFDN1
gene id: 9031:PFDN1
uniprot id: A0A1D5PB69
uniprot id: F1NDS5
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9031:GDF5
gene id: 9031:GDF5
uniprot id: Q9W6G0
names: Similarity
messages: Belongs to the TGF-beta family.

9031:SLC9A3
gene id: 9031:SLC9A3
uniprot id: A0A1D5NYQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

9031:CGTL
gene id: 9031:CGTL
uniprot id: F1P296
names: Subcellular Location Annotation
messages: Membrane

9031:CTH
gene id: 9031:CTH
uniprot id: E1BYF1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

9031:DCTD
gene id: 9031:DCTD
uniprot id: Q5ZJM4
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9031:MTR
gene id: 9031:MTR
uniprot id: F1NLY0
uniprot id: Q5ZIC7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

9031:SPDYA
gene id: 9031:SPDYA
uniprot id: E1C1Y3
names: Similarity
messages: Belongs to the Speedy/Ringo family.

9031:WNT8A
gene id: 9031:WNT8A
uniprot id: P51030
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Cells that form rhombomere 4. Hensen node and the neural plate immediately anterior to it.
messages: Expressed during embryogenesis.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Is likely to signal over only few cell diameters. May be involved in the regulation of axis formation and in the rhombomere specification.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
messages: Proteolytic processing by tiki1 and tiki2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of wnt8c.
messages: extracellular matrix

9031:TATDN1
gene id: 9031:TATDN1
uniprot id: A0A1D5PNF2
uniprot id: A0A1D5PQK9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

9031:ZRANB2
gene id: 9031:ZRANB2
uniprot id: Q5ZLX5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: May regulate alternative splicing by interfering with constitutive 5'-splice site selection.
messages: Nucleus
messages: The RanBP2-type zinc fingers mediate binding to RNA.

9031:RCOR3
gene id: 9031:RCOR3
uniprot id: Q5ZJ40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoREST family.
messages: May act as a component of a corepressor complex that represses transcription.
messages: Nucleus

9031:PPP1R21
gene id: 9031:PPP1R21
uniprot id: Q5ZL12
names: Function
names: Subcellular Location Annotation
messages: Early endosome
messages: Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway.

9031:SERPINI1
gene id: 9031:SERPINI1
uniprot id: A0A5H1ZRK4
uniprot id: Q90935
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Detected in embryonic ocular vitreous fluid (at protein level) (PubMed:9442076). In the embryo present in retina, brain, cerebellum and spinal cord (PubMed:8670795). In adult, predominantly expressed in the brain (PubMed:8670795).
messages: Perikaryon
messages: Secreted
messages: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
messages: secretory vesicle lumen

9031:TEC
gene id: 9031:TEC
uniprot id: F1NZY8
uniprot id: Q5ZI88
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:AANAT
gene id: 9031:AANAT
uniprot id: P79774
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acetyltransferase family. AANAT subfamily.
messages: Catalyzes the N-acetylation of serotonin into N-acetylserotonin.
messages: Cytoplasm
messages: Exhibits circadian rhythm pattern in the pineal gland with highest levels at ZT 24. Expression in the retinal photoreceptor cells oscillates in a circadian manner.
messages: Expressed in follicular pineal cells and retinal photoreceptors with five times more expression in the pineal gland.
messages: Monomer (By similarity). Interacts with YWHAZ; the interaction requires phosphorylation on Thr-29, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-203 site, the other ywhaz monomer with similar effect (By similarity).
messages: Phosphorylated; cAMP-dependent phosphorylation on both N-terminal and C-terminal sites regulates AANAT activity through allowing interaction with 14-3-3 proteins and protecting the enzyme against proteasomal degradation.

9031:PHF5A
gene id: 9031:PHF5A
uniprot id: E1BV20
names: Similarity
messages: Belongs to the PHF5 family.

9031:SEPTIN9
gene id: 9031:SEPTIN9
uniprot id: Q5F3T2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:SLC25A17
gene id: 9031:SLC25A17
uniprot id: E1BSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:SLC35F1
gene id: 9031:SLC35F1
uniprot id: A0A3Q2TW83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9031:VPS26B
gene id: 9031:VPS26B
uniprot id: F1NPH4
names: Similarity
messages: Belongs to the VPS26 family.

9031:CDK10
gene id: 9031:CDK10
uniprot id: F1NCQ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:NFIX
gene id: 9031:NFIX
uniprot id: Q90932
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9031:PRPF38A
gene id: 9031:PRPF38A
uniprot id: E1C6A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9031:SBNO1
gene id: 9031:SBNO1
uniprot id: Q5F371
names: Similarity
messages: Belongs to the SBNO family.

9031:SLC22A5
gene id: 9031:SLC22A5
uniprot id: Q5W4T3
names: Subunit
messages: Interacts with PDZK1.

9031:UBE2E2
gene id: 9031:UBE2E2
uniprot id: A0A3Q2U636
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:CALB2
gene id: 9031:CALB2
uniprot id: P07090
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9031:SRSF4
gene id: 9031:SRSF4
uniprot id: A0A3Q2UIV1
names: Similarity
messages: Belongs to the splicing factor SR family.

9031:CRYBA1
gene id: 9031:CRYBA1
uniprot id: P10042
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9031:GRK7
gene id: 9031:GRK7
uniprot id: E1C4P5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9031:PGAM1
gene id: 9031:PGAM1
uniprot id: Q5ZLN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate.
messages: Homodimer.

9031:TP53INP1
gene id: 9031:TP53INP1
uniprot id: A0A1D5PSS7
uniprot id: Q5F460
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9031:RP2
gene id: 9031:RP2
uniprot id: Q5ZHN4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as a GTPase-activating protein. May act as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins (By similarity).
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Myristoylated on Gly-2; which may be required for membrane targeting.
messages: Palmitoylated on Cys-3; which may be required for plasma membrane targeting.

9031:GALNT11
gene id: 9031:GALNT11
uniprot id: E1BYU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:AQP1
gene id: 9031:AQP1
uniprot id: Q2MCJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:ADRA1D
gene id: 9031:ADRA1D
uniprot id: A0A1D5PRZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9031:SYN3
gene id: 9031:SYN3
uniprot id: A0A1D5PMP8
names: Similarity
messages: Belongs to the synapsin family.

9031:MYH9
gene id: 9031:MYH9
uniprot id: P14105
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
messages: Cortical granule
messages: Expressed in fibroblasts, brain, lung, kidney, spleen, and skeletal, cardiac and smooth muscles.
messages: Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: cell cortex
messages: cytoskeleton

9031:BANP
gene id: 9031:BANP
uniprot id: A0A1D5PZV3
uniprot id: E1C113
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9031:SLC35B4
gene id: 9031:SLC35B4
uniprot id: A0A1D5NUD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9031:LOC431317
gene id: 9031:LOC431317
uniprot id: A0A3Q2U8S2
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:CENPE
gene id: 9031:CENPE
uniprot id: E1BQJ6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:NAA25
gene id: 9031:NAA25
uniprot id: A0A1D5P768
uniprot id: Q5F3J0
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9031:XRCC5
gene id: 9031:XRCC5
uniprot id: A0A3Q2UA13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

9031:GNA13
gene id: 9031:GNA13
uniprot id: A0A1D5PQE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9031:ITGB5
gene id: 9031:ITGB5
uniprot id: Q6T683
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9031:GGT2
gene id: 9031:GGT2
uniprot id: F1NVY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9031:LOC771066
gene id: 9031:LOC771066
uniprot id: R4GJJ9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:TMEM230
gene id: 9031:TMEM230
uniprot id: Q5ZLH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

9031:ATP1B3
gene id: 9031:ATP1B3
uniprot id: P33879
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Predominantly expressed in brain.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
messages: Was originally thought to be the beta-2 subunit.

9031:SLC40A1
gene id: 9031:SLC40A1
uniprot id: Q5F3K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

9031:HDX
gene id: 9031:HDX
uniprot id: Q5ZKW8
names: Subcellular Location Annotation
messages: Nucleus

9031:UTP15
gene id: 9031:UTP15
uniprot id: Q5F3D7
names: Function
names: Subcellular Location Annotation
messages: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.
messages: nucleolus

9031:IL5
gene id: 9031:IL5
uniprot id: Q5W4T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

9031:DYNC2LI1
gene id: 9031:DYNC2LI1
uniprot id: F1NGV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

9031:RRP12
gene id: 9031:RRP12
uniprot id: Q5ZKD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP12 family.
messages: Nucleus membrane
messages: nucleolus

9031:CDC14A
gene id: 9031:CDC14A
uniprot id: D5K9Y5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9031:COL17A1
gene id: 9031:COL17A1
uniprot id: Q90584
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cornea specific.
messages: Homotrimers of alpha 1(XVII)chains.
messages: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.
messages: Membrane
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion.
messages: The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen homolog. The shedding is mediated by membrane-bound metalloproteases (By similarity).
messages: The intracellular/endo domain is disulfide-linked.
messages: basement membrane
messages: hemidesmosome

9031:GFI1B
gene id: 9031:GFI1B
uniprot id: O42409
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
messages: Expressed in erythroid cells of primitive and definitive lineage and bone marrow cells.
messages: Nucleus
messages: The zinc finger domain is essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.

9031:RREB1
gene id: 9031:RREB1
uniprot id: O57415
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Broadly expressed, except in brain.
messages: Nucleus
messages: Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters.

9031:SEC22A
gene id: 9031:SEC22A
uniprot id: Q5ZIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9031:GREM2
gene id: 9031:GREM2
uniprot id: A0A3Q3AYA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9031:KCNJ15
gene id: 9031:KCNJ15
uniprot id: A0A3Q2TVJ3
uniprot id: F1P0R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9031:P4HB
gene id: 9031:P4HB
uniprot id: A0A1D5PV06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9031:POFUT1
gene id: 9031:POFUT1
uniprot id: Q8AWB4
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

9031:ZDHHC3
gene id: 9031:ZDHHC3
uniprot id: A0A1D5PVV6
uniprot id: A0A3Q2TSS4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:ACSS3
gene id: 9031:ACSS3
uniprot id: F1P5S5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9031:SEC22B
gene id: 9031:SEC22B
uniprot id: Q5ZJW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synaptobrevin family.
messages: Component of 2 distinct SNARE complexes.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9031:SF3A3
gene id: 9031:SF3A3
uniprot id: Q5F387
names: Similarity
messages: Belongs to the SF3A3 family.

9031:HNRNPA1
gene id: 9031:HNRNPA1
uniprot id: Q5ZLB3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:PQLC1
gene id: 9031:PQLC1
uniprot id: A0A3Q2U1K3
names: Subcellular Location Annotation
messages: Membrane

9031:EGF
gene id: 9031:EGF
uniprot id: Q6PPB4
names: Caution
names: Function
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
messages: Interacts with EGFR and promotes EGFR dimerization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:NEUROD2
gene id: 9031:NEUROD2
uniprot id: A0A1D5PAJ0
names: Subcellular Location Annotation
messages: Nucleus

9031:FAM234B
gene id: 9031:FAM234B
uniprot id: Q5F3L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM234 family.
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

9031:TDRD7
gene id: 9031:TDRD7
uniprot id: R9PXP1
names: Subcellular Location Annotation
messages: Cytoplasm

9031:RHBDF1
gene id: 9031:RHBDF1
uniprot id: A0A3Q2TSP2
uniprot id: A0A3Q3AKI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

9031:IGF2R
gene id: 9031:IGF2R
uniprot id: Q90681
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:MSH2
gene id: 9031:MSH2
uniprot id: F1NV33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

9031:SLC2A14
gene id: 9031:SLC2A14
uniprot id: P28568
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Deoxyglucose transport is inhibit by D-glucose, D-galactose and maltose. Galactose transport is inhibited by D-glucose and maltose.
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9031:POLE
gene id: 9031:POLE
uniprot id: A0A1D5PPC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

9031:TRMT1L
gene id: 9031:TRMT1L
uniprot id: A0A1D5NZG5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9031:POLR3F
gene id: 9031:POLR3F
uniprot id: E1BU41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9031:AGO1
gene id: 9031:AGO1
uniprot id: A0A1D5PXD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

9031:SLC29A3
gene id: 9031:SLC29A3
uniprot id: A0A3Q2U8J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9031:TMOD2
gene id: 9031:TMOD2
uniprot id: A0A1D5PW62
names: Subcellular Location Annotation
messages: cytoskeleton

9031:CEP44
gene id: 9031:CEP44
uniprot id: E1C687
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

9031:PEX2
gene id: 9031:PEX2
uniprot id: Q5ZM64
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

9031:TRAPPC2
gene id: 9031:TRAPPC2
uniprot id: A0A1I7Q427
uniprot id: Q5ZKP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Nucleus
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: perinuclear region

9031:TPM4
gene id: 9031:TPM4
uniprot id: F1NK75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9031:RTN4IP1
gene id: 9031:RTN4IP1
uniprot id: A0A3Q2UAN0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9031:TET2
gene id: 9031:TET2
uniprot id: F1NJ90
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

9031:NPFFR1
gene id: 9031:NPFFR1
uniprot id: Q75XU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9031:VCL
gene id: 9031:VCL
uniprot id: P12003
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylated; mainly by myristic acid but also by a small amount of palmitic acid.
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Exhibits self-association properties. Interacts with APBB1IP, NRAP and TLN1. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.
messages: Exists in at least two conformations. When in the closed, 'inactive' conformation, extensive interactions between the head and tail domains prevent detectable binding to most of its ligands. It takes on an 'active' conformation after cooperative and simultaneous binding of two different ligands. This activation involves displacement of the head-tail interactions and leads to a significant accumulation of ternary complexes. The active form then binds a number of proteins that have both signaling and structural roles that are essential for cell adhesion.
messages: Isoform Metavinculin is muscle-specific.
messages: Phosphorylated; on serines, threonines and tyrosines. Phosphorylation on Tyr-1134 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques.
messages: The N-terminal globular head (Vh) comprises of subdomains D1-D4. The C-terminal tail (Vt) binds F-actin and cross-links actin filaments into bundles. An intramolecular interaction between Vh and Vt masks the F-actin-binding domain located in Vt. The binding of talin and alpha-actinin to the D1 subdomain of vinculin induces a helical bundle conversion of this subdomain, leading to the disruption of the intramolecular interaction and the exposure of the cryptic F-actin-binding domain of Vt. Vt inhibits actin filament barbed end elongation without affecting the critical concentration of actin assembly.
messages: adherens junction
messages: cytoskeleton
messages: focal adhesion
messages: sarcolemma

9031:ANO1
gene id: 9031:ANO1
uniprot id: A0A1D5P1I5
uniprot id: A0A3Q2U0X0
uniprot id: A0A3Q2U3V2
uniprot id: A0A3Q3A869
uniprot id: A0A3Q3B1P7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:PANX2
gene id: 9031:PANX2
uniprot id: E1C5A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9031:APLNR
gene id: 9031:APLNR
uniprot id: E1C968
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:RAG2
gene id: 9031:RAG2
uniprot id: A0A1L1RM35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9031:EPC2
gene id: 9031:EPC2
uniprot id: E1C8I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9031:TBC1D23
gene id: 9031:TBC1D23
uniprot id: Q5F415
names: Function
names: Subcellular Location Annotation
messages: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development (By similarity). May act as a general inhibitor of innate immunity signaling (By similarity).
messages: trans-Golgi network

9031:CC2D1A
gene id: 9031:CC2D1A
uniprot id: E1C6S7
names: Similarity
messages: Belongs to the CC2D1 family.

9031:MTHFD2
gene id: 9031:MTHFD2
uniprot id: Q5ZKA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Mitochondrion

9031:SSBP2
gene id: 9031:SSBP2
uniprot id: F1NTD5
names: Subcellular Location Annotation
messages: Nucleus

9031:TMEM132B
gene id: 9031:TMEM132B
uniprot id: F1N8B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9031:AGTPBP1
gene id: 9031:AGTPBP1
uniprot id: A0A3Q2U149
uniprot id: R9PXP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9031:LOC772096
gene id: 9031:LOC772096
uniprot id: C0J3M4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TRMT5
gene id: 9031:TRMT5
uniprot id: A0A1D5PKQ7
uniprot id: F1NFG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

9031:NKAIN1
gene id: 9031:NKAIN1
uniprot id: F1NJ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9031:STARD5
gene id: 9031:STARD5
uniprot id: F1NPH6
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9031:NUDC
gene id: 9031:NUDC
uniprot id: Q5ZIN1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation (By similarity).
messages: Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation is necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity).
messages: cytoskeleton
messages: spindle

9031:LOC121106434
gene id: 9031:LOC121106434
uniprot id: R4GFI6
names: Subcellular Location Annotation
messages: Membrane

9031:TYR
gene id: 9031:TYR
uniprot id: A0A411DFI8
uniprot id: P55024
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.
messages: Melanosome
messages: Melanosome membrane
messages: Membrane
messages: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity).

9031:TACSTD2
gene id: 9031:TACSTD2
uniprot id: F1NJR8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:TPMT
gene id: 9031:TPMT
uniprot id: F1NGW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm

9031:TAF1D
gene id: 9031:TAF1D
uniprot id: F1NY03
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9031:TJP2
gene id: 9031:TJP2
uniprot id: F1NK34
uniprot id: Q9YHV2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9031:SPTY2D1
gene id: 9031:SPTY2D1
uniprot id: E1BUG7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT2 family.
messages: Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro) (By similarity). Modulates RNA polymerase 1-mediated transcription (PubMed:23378026). Required for optimal growth in the presence of the DNA damaging agents actinomycin D or mitomycin C (in vitro) (PubMed:23378026). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity).
messages: Interacts with POLR1A (Probable) (PubMed:23378026). Interacts with histones (PubMed:23378026). Interacts with a heterotetrameric complex formed by histone H3 and H4, especially when the histone tetramer is not bound to DNA (By similarity).
messages: The acidic C-terminal domain mediates interaction with histone H3/H4 complexes.
messages: nucleolus

9031:LANCL3
gene id: 9031:LANCL3
uniprot id: E1C809
names: Similarity
messages: Belongs to the LanC-like protein family.

9031:KIF5C
gene id: 9031:KIF5C
uniprot id: F1NE00
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:ACOD1
gene id: 9031:ACOD1
uniprot id: A0A3Q3AW51
uniprot id: Q5ZIP5
names: Similarity
messages: Belongs to the PrpD family.

9031:PTGER2
gene id: 9031:PTGER2
uniprot id: A2TH15
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:CCNJL
gene id: 9031:CCNJL
uniprot id: A0A1D5PRD8
uniprot id: A0A3Q2U5E0
names: Similarity
messages: Belongs to the cyclin family.

9031:OSGEPL1
gene id: 9031:OSGEPL1
uniprot id: A0A1D5PWZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

9031:KYNU
gene id: 9031:KYNU
uniprot id: F1NDY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:RET
gene id: 9031:RET
uniprot id: A0A1L1RML1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

9031:CCT7
gene id: 9031:CCT7
uniprot id: F1NK38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

9031:TAOK3
gene id: 9031:TAOK3
uniprot id: Q9I9E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of MAPK8/JNK cascade (By similarity).

9031:ANKMY2
gene id: 9031:ANKMY2
uniprot id: Q5ZMD2
names: Function
names: Subcellular Location Annotation
messages: May be involved in the trafficking of signaling proteins to the cilia.
messages: cilium

9031:FAM221A
gene id: 9031:FAM221A
uniprot id: E1BS42
names: Similarity
messages: Belongs to the FAM221 family.

9031:CKAP2
gene id: 9031:CKAP2
uniprot id: Q5ZJF0
names: Similarity
messages: Belongs to the CKAP2 family.

9031:SUCLG2
gene id: 9031:SUCLG2
uniprot id: Q5ZL37
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9031:GNB5
gene id: 9031:GNB5
uniprot id: A0A1D5P714
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9031:EHHADH
gene id: 9031:EHHADH
uniprot id: A0A3Q3AV17
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9031:INTS7
gene id: 9031:INTS7
uniprot id: Q5ZL91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 7 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Chromosome
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. May play a role in DNA damage response (DDR) signaling during the S phase.
messages: Nucleus

9031:IMMT
gene id: 9031:IMMT
uniprot id: A0A3Q3AHD7
uniprot id: Q5ZMI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9031:TMEM200A
gene id: 9031:TMEM200A
uniprot id: E1BT36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

9031:GASTL
gene id: 9031:GASTL
uniprot id: R4GL36
names: Similarity
messages: Belongs to the peptidase A1 family.

9031:COX7A2L
gene id: 9031:COX7A2L
uniprot id: A0A1D5NWJ7
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9031:PMPCB
gene id: 9031:PMPCB
uniprot id: F1P3S2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Mitochondrion matrix

9031:BMT2
gene id: 9031:BMT2
uniprot id: Q5ZJ87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

9031:PANK4
gene id: 9031:PANK4
uniprot id: E1BV98
names: Similarity
names: Subunit
messages: Belongs to the type II pantothenate kinase family.
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.

9031:KCNA6
gene id: 9031:KCNA6
uniprot id: A0A1D5PP83
names: Subcellular Location Annotation
messages: Membrane

9031:RRM2B
gene id: 9031:RRM2B
uniprot id: A0A1D5PI47
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9031:ZDHHC16
gene id: 9031:ZDHHC16
uniprot id: E1BZS7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:INSL5
gene id: 9031:INSL5
uniprot id: A0A8K1B0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9031:GCNT4
gene id: 9031:GCNT4
uniprot id: E1C421
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9031:IRF5
gene id: 9031:IRF5
uniprot id: Q5ZJM5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:ADCY6
gene id: 9031:ADCY6
uniprot id: A0A1D5P0J0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9031:NDUFAF4
gene id: 9031:NDUFAF4
uniprot id: E1C7K8
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9031:VIPR1
gene id: 9031:VIPR1
uniprot id: A5A0U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9031:LOC101751878
gene id: 9031:LOC101751878
uniprot id: A0A1D5PFA0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:RHCE
gene id: 9031:RHCE
uniprot id: Q7T0L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9031:VEGFC
gene id: 9031:VEGFC
uniprot id: E1C7C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

9031:DRC1
gene id: 9031:DRC1
uniprot id: F1NGP0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC1 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum axoneme

9031:SMARCD3
gene id: 9031:SMARCD3
uniprot id: A0A1D5PGF8
uniprot id: A0A3Q2UI83
names: Similarity
messages: Belongs to the SMARCD family.

9031:POLE2
gene id: 9031:POLE2
uniprot id: Q5ZKQ6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus

9031:FAM19A1
gene id: 9031:FAM19A1
uniprot id: A0A1D5PJ76
uniprot id: A0A3Q2UD59
names: Similarity
messages: Belongs to the TAFA family.

9031:TIMP2
gene id: 9031:TIMP2
uniprot id: O42146
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
messages: Secreted
messages: The activity of TIMP2 is dependent on the presence of disulfide bonds.

9031:ARSI
gene id: 9031:ARSI
uniprot id: F1NQP9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:FOXJ3
gene id: 9031:FOXJ3
uniprot id: A0A3Q3AWD2
uniprot id: E1BTL6
names: Subcellular Location Annotation
messages: Nucleus

9031:CRCP
gene id: 9031:CRCP
uniprot id: A0A1D5P987
uniprot id: F1NHW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9031:CCM2
gene id: 9031:CCM2
uniprot id: A0A3Q2TW80
uniprot id: E1C144
names: Similarity
messages: Belongs to the CCM2 family.

9031:ACAD9
gene id: 9031:ACAD9
uniprot id: Q5ZJ68
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9031:NEDD9
gene id: 9031:NEDD9
uniprot id: A0A3Q2TVN1
uniprot id: F1NW90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9031:IRF6
gene id: 9031:IRF6
uniprot id: A0A3Q2TRU7
uniprot id: A0A3Q2TX45
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:EDC4
gene id: 9031:EDC4
uniprot id: A0A1D5P1Q3
uniprot id: A0A1D5PW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: P-body

9031:CLVS2
gene id: 9031:CLVS2
uniprot id: E1C6S0
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

9031:ASIP
gene id: 9031:ASIP
uniprot id: B0ZDU3
names: Subcellular Location Annotation
messages: Secreted

9031:FAM168A
gene id: 9031:FAM168A
uniprot id: E1C589
names: Similarity
messages: Belongs to the FAM168 family.

9031:MRPS14
gene id: 9031:MRPS14
uniprot id: A0A1D5NYX9
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

9031:PSMD7
gene id: 9031:PSMD7
uniprot id: F1NR71
names: Similarity
messages: Belongs to the peptidase M67A family.

9031:KCNJ12
gene id: 9031:KCNJ12
uniprot id: F1NHE9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inward rectifier-type potassium channel family.
messages: Cell membrane
messages: Homotetramer.
messages: Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions.
messages: Membrane
messages: Phosphatidylinositol 4,5-bisphosphate binding to the cytoplasmic side of the channel triggers a conformation change leading to channel opening.

9031:HMGCS1
gene id: 9031:HMGCS1
uniprot id: A0A1L1RZ64
uniprot id: P23228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.
messages: Cytoplasm
messages: Homodimer.

9031:HMX3
gene id: 9031:HMX3
uniprot id: O57601
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMX homeobox family.
messages: Expressed in the otic placode beginning at stage 10 and exhibits a dynamic expression pattern during formation and further differentiation of the otic vesicle.
messages: Nucleus
messages: Regulated by DAN in inner ear.
messages: Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity).

9031:GRM3
gene id: 9031:GRM3
uniprot id: E1BUE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

9031:TMEM136-1
gene id: 9031:TMEM136-1
uniprot id: A0A1D5NZD1
names: Subcellular Location Annotation
messages: Membrane

9031:ACYP2
gene id: 9031:ACYP2
uniprot id: P07031
names: Function
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Its physiological role is not yet clear.

9031:MAP2K6
gene id: 9031:MAP2K6
uniprot id: A0A1D5PHN6
uniprot id: F1NVF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:XPO7
gene id: 9031:XPO7
uniprot id: A0A1D5PWR9
uniprot id: Q5ZLT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Mediates the nuclear export of proteins (cargos) with broad substrate specificity.
messages: Nucleus

9031:TRMT6
gene id: 9031:TRMT6
uniprot id: F1NF40
uniprot id: Q5ZJK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

9031:PRKCZ
gene id: 9031:PRKCZ
uniprot id: E1BQN6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

9031:RUVBL1
gene id: 9031:RUVBL1
uniprot id: Q5ZIC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9031:ADORA2B
gene id: 9031:ADORA2B
uniprot id: O13076
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9031:RAB32
gene id: 9031:RAB32
uniprot id: F1NBL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9031:NKAIN4
gene id: 9031:NKAIN4
uniprot id: A0A1D5PKU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9031:EPGN
gene id: 9031:EPGN
uniprot id: Q5EG71
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Promotes the growth of epithelial cells.

9031:IRX1
gene id: 9031:IRX1
uniprot id: Q9I9C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9031:PALM2AKAP2
gene id: 9031:PALM2AKAP2
uniprot id: F1NCB1
names: Similarity
messages: Belongs to the paralemmin family.

9031:BPIFB2
gene id: 9031:BPIFB2
uniprot id: O42273
names: Developmental Stage
names: Function
names: Induction
names: Tissue Specificity
messages: Down-regulated by dietary stress. Significantly decreased expression between days 0 to 5 in egg whites of eggs laid by corticosterone-fed hens (at protein level). Decreased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens.
messages: Expressed in developing retina and brain, but not in heart, liver or kidney. In brain, located in a narrow strip in the boundary between the ventricular zone (consisting of proliferating cells) and the intermediate zone (consisting of postmitotic, differentiating cells). Expressed in all major regions of the developing brain, including the myelencephalon, the mesencephalon, the telencephalon and the diencephalon. In the developing retina, expression is scattered across the retinal neural epithelium (PubMed:9514522). Expressed in egg white (at protein level). Expressed in the magnum of the oviduct (at protein level) (PubMed:25436390).
messages: In brain, not abundant during the early stages of neurogenesis. Expression increases during cytogenesis followed by a rapid decrease towards the end of cytogenesis. Undetectable at 16 dpc. In retina, expression is detected at 4 dpc and 6 dpc, and becomes scarce by 8 dpc. Not detected in the mature retina.
messages: May play a role in the developmental transition from cell proliferation to cell differentiation during neurogenesis.

9031:AKAP12
gene id: 9031:AKAP12
uniprot id: A0A1D5PLE4
names: Subcellular Location Annotation
messages: Membrane

9031:ESRRG
gene id: 9031:ESRRG
uniprot id: Q5UKY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9031:LOC419584
gene id: 9031:LOC419584
uniprot id: A0A3Q2TXW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:HOPX
gene id: 9031:HOPX
uniprot id: Q8JHU0
names: Function
names: Subcellular Location Annotation
messages: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. May act via an interaction with SRF, leading to modulate the expression of SRF-dependent cardiac-specific genes and cardiac development. May act as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assist in chaperone-mediated protein refolding.
messages: Cytoplasm
messages: Nucleus

9031:MCOLN2
gene id: 9031:MCOLN2
uniprot id: E1BWI2
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9031:ADPRH
gene id: 9031:ADPRH
uniprot id: Q5ZMJ1
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9031:GSTM2
gene id: 9031:GSTM2
uniprot id: P20136
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity) (PubMed:10903867). Participates in the formation of novel hepoxilin regioisomers (By similarity).
messages: Cytoplasm
messages: Homodimer.

9031:CCNA2
gene id: 9031:CCNA2
uniprot id: P43449
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
messages: Cytoplasm
messages: Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes.
messages: Nucleus

9031:SETD6
gene id: 9031:SETD6
uniprot id: F1P3Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

9031:NDUFS3
gene id: 9031:NDUFS3
uniprot id: F1ND23
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

9031:PLEKHF2
gene id: 9031:PLEKHF2
uniprot id: Q5ZLY5
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endoplasmic reticulum
messages: May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
messages: The FYVE domain is important for binding to the endosomal membrane.

9031:SNAPIN
gene id: 9031:SNAPIN
uniprot id: R4GG77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

9031:MAP1LC3A
gene id: 9031:MAP1LC3A
uniprot id: A0A1D5PFR7
names: Similarity
messages: Belongs to the ATG8 family.

9031:FANCC
gene id: 9031:FANCC
uniprot id: F1NYH1
uniprot id: Q5F3H0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.
messages: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
messages: Nucleus

9031:SLC25A32
gene id: 9031:SLC25A32
uniprot id: Q5ZJN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:URAH
gene id: 9031:URAH
uniprot id: E1C8H1
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Homotetramer.

9031:DYNC1LI1
gene id: 9031:DYNC1LI1
uniprot id: Q90828
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity).
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs) (By similarity).
messages: Phosphorylated.
messages: cytoskeleton

9031:SDC1
gene id: 9031:SDC1
uniprot id: F1NV24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane
messages: extracellular exosome

9031:WASL
gene id: 9031:WASL
uniprot id: E1BTH9
names: Subcellular Location Annotation
messages: Nucleus

9031:SLC30A6
gene id: 9031:SLC30A6
uniprot id: Q5ZIH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (Probable). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (By similarity).
messages: Heterodimer with SLC30A5; form a functional zinc ion transmembrane transporter.
messages: Hydrophilic histidine residues that participate to zinc binding in transporters of the family are not conserved in SLC30A6.
messages: trans-Golgi network membrane

9031:CDH8
gene id: 9031:CDH8
uniprot id: A6YJX2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9031:TSPAN14
gene id: 9031:TSPAN14
uniprot id: F1NYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:IFNA3
gene id: 9031:IFNA3
uniprot id: P42165
uniprot id: Q38IF1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears first at 3 hours post-infection, increases to give the strongest signal at about 9 hours and gradually wanes to almost nothing at 24 hours.
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:CCM2L
gene id: 9031:CCM2L
uniprot id: E1BZ83
names: Similarity
messages: Belongs to the CCM2 family.

9031:GHSR
gene id: 9031:GHSR
uniprot id: Q7ZT14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

9031:MRPL2
gene id: 9031:MRPL2
uniprot id: F1NY85
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9031:ACTN2
gene id: 9031:ACTN2
uniprot id: P20111
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-actinin family.
messages: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).
messages: Homodimer; antiparallel.
messages: Ubiquitinated by FBXL22, leading to proteasomal degradation.
messages: Z line

9031:PTGES2
gene id: 9031:PTGES2
uniprot id: A0A1D5PE83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

9031:PHF19
gene id: 9031:PHF19
uniprot id: E1BYX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9031:SSTR5
gene id: 9031:SSTR5
uniprot id: F6RCI2
uniprot id: Q58G83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:ANKRD34B
gene id: 9031:ANKRD34B
uniprot id: A0A1L1RSA7
names: Similarity
messages: Belongs to the ANKRD34 family.

9031:PCBP4
gene id: 9031:PCBP4
uniprot id: R4GF92
names: Subcellular Location Annotation
messages: Cytoplasm

9031:VIP
gene id: 9031:VIP
uniprot id: P48143
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: PHI also causes vasodilation.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

9031:TAS2R40
gene id: 9031:TAS2R40
uniprot id: Q2AB83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Bitter taste receptor (PubMed:25796330). Binds quinine, dextromethorphan, diphenhydramine, diphenidol, chlorpheniramine, diphenidol, chloramphenicol, chloroquine and coumarin, this latter being a weak agonist, as well as epiquinidine, ethylhydrocupreine and quinidine (PubMed:28811548).
messages: Cell membrane
messages: Expressed in the oral cavity, as well as in the gastrointestinal tract, including in the upper palate, tongue, proventriculus, ventriculus, duodenum, jejunum, ileum, cecum and colon.

9031:GINS2
gene id: 9031:GINS2
uniprot id: A0A1D5PQM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9031:TPST2
gene id: 9031:TPST2
uniprot id: F1NGS3
uniprot id: Q5ZJI0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane
messages: Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft.

9031:CNTN5
gene id: 9031:CNTN5
uniprot id: Q90W79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: Contactins mediate cell surface interactions during nervous system development. May contribute to the formation of somatotopic maps of cerebellar afferents during the development of the nervous system.
messages: Expressed by subpopulations of Purkinje cells in the cerebellum. Also expressed by one type of Purkinje cell afferents, the climbing fibers.
messages: Interacts with INgCAM/L1 and the tenascin-R TNP protein. Does not interacts with NrCAM.

9031:ZNF592
gene id: 9031:ZNF592
uniprot id: A0A1D5NW99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9031:TPI1
gene id: 9031:TPI1
uniprot id: P00940
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

9031:PARVB
gene id: 9031:PARVB
uniprot id: E1C891
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

9031:NMD3
gene id: 9031:NMD3
uniprot id: E1BTL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

9031:AvBD9
gene id: 9031:AvBD9
uniprot id: Q6QLR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Has bactericidal activity. Potent activity against C.jejuni, C.perfringens, S.aureus, C.albicans and S.cerevisiae. Less potent against S.typhimurium and E.coli.
messages: Secreted
messages: Strong expression in the testis, liver, gall bladder, kidney, esophagus and crop. Also expressed in the glandular stomach, ovary and male and female reproductive tracts. Low expression in the intestinal tract. Expressed in the ovarian stroma, but not in the ovarian follicles.

9031:RIF1
gene id: 9031:RIF1
uniprot id: E1C2U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIF1 family.
messages: Chromosome
messages: Interacts with TP53BP1 (when phosphorylated by ATM).
messages: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:23333306). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).
messages: Nucleus
messages: spindle
messages: telomere

9031:C1S
gene id: 9031:C1S
uniprot id: Q5F3N3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:AGPAT5
gene id: 9031:AGPAT5
uniprot id: E1BSZ0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:DIAPH2
gene id: 9031:DIAPH2
uniprot id: Q9DEH3
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

9031:ARGLU1
gene id: 9031:ARGLU1
uniprot id: Q5ZL35
names: Similarity
messages: Belongs to the UPF0430 family.

9031:LOC421740
gene id: 9031:LOC421740
uniprot id: F1NRI9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:CCDC90B
gene id: 9031:CCDC90B
uniprot id: A0A1L1RQ34
names: Similarity
messages: Belongs to the CCDC90 family.

9031:TRIAP1
gene id: 9031:TRIAP1
uniprot id: E1C3C0
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

9031:YPEL5
gene id: 9031:YPEL5
uniprot id: Q5ZIK4
names: Similarity
messages: Belongs to the yippee family.

9031:EXO1
gene id: 9031:EXO1
uniprot id: A0A024F8U1
uniprot id: E1C1G7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9031:MMADHC
gene id: 9031:MMADHC
uniprot id: Q5ZKP2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer with MMACHC. Forms a multiprotein complex with MMACHC, MTR and MTRR.
messages: Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Mitochondrion

9031:LOC101747503
gene id: 9031:LOC101747503
uniprot id: Q2AB82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9031:RPL26L1
gene id: 9031:RPL26L1
uniprot id: F2Z4K6
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9031:MYC
gene id: 9031:MYC
uniprot id: A0A167VDX5
uniprot id: P01109
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.

9031:TUBA3E
gene id: 9031:TUBA3E
uniprot id: F1NWX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:SAP18
gene id: 9031:SAP18
uniprot id: Q90ZH5
names: Function
names: Similarity
messages: Belongs to the SAP18 family.
messages: Involved in the tethering of the SIN3 complex to core histone proteins.

9031:EHD4
gene id: 9031:EHD4
uniprot id: A0A3Q2UHT9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane

9031:AQP5
gene id: 9031:AQP5
uniprot id: A0A1D5P9U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:SCG5
gene id: 9031:SCG5
uniprot id: Q5ZI41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 7B2 family.
messages: Secreted

9031:SPAG9
gene id: 9031:SPAG9
uniprot id: A0A1D5PET9
names: Similarity
messages: Belongs to the JIP scaffold family.

9031:OTP
gene id: 9031:OTP
uniprot id: R4GH47
names: Subcellular Location Annotation
messages: Nucleus

9031:SEMA3E
gene id: 9031:SEMA3E
uniprot id: O42237
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.
messages: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation (By similarity).
messages: Secreted
messages: Strong binding to neuropilin is mediated by the carboxy third of the protein.

9031:EPYC
gene id: 9031:EPYC
uniprot id: Q90944
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.
messages: Preferentially expressed in flattened chondrocytes of developing chick limb cartilage. Also found in the cartilage peripheral zone bordering with bone marrow cavity.
messages: The O-linked glycosaminoglycan chain(s) are dermatan sulfate.
messages: extracellular matrix

9031:SDHAF4
gene id: 9031:SDHAF4
uniprot id: A0A1D5PX55
names: Similarity
messages: Belongs to the SDHAF4 family.

9031:HIP1R
gene id: 9031:HIP1R
uniprot id: Q5ZJZ1
names: Similarity
messages: Belongs to the SLA2 family.

9031:THBS1
gene id: 9031:THBS1
uniprot id: F1P0J8
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:NUBP1
gene id: 9031:NUBP1
uniprot id: E1C129
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.

9031:MELTF
gene id: 9031:MELTF
uniprot id: F1NVN3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted

9031:CRHR2
gene id: 9031:CRHR2
uniprot id: A0A3Q2UBF9
uniprot id: Q7ZZZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

9031:MYO1H
gene id: 9031:MYO1H
uniprot id: E1BXA7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:NHLRC2
gene id: 9031:NHLRC2
uniprot id: Q5ZI67
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Required for normal embryonic development.
messages: cytosol

9031:LAMTOR3
gene id: 9031:LAMTOR3
uniprot id: Q5ZIP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMTOR3 family.
messages: Late endosome membrane
messages: Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade.

9031:NRAS
gene id: 9031:NRAS
uniprot id: Q5F352
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

9031:C3orf70
gene id: 9031:C3orf70
uniprot id: A0A3Q2UF71
names: Similarity
messages: Belongs to the UPF0524 family.

9031:LYSMD3
gene id: 9031:LYSMD3
uniprot id: Q5ZKK0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Essential for Golgi structural integrity.
messages: Golgi apparatus

9031:CDS2
gene id: 9031:CDS2
uniprot id: A0A1D5PAV3
uniprot id: A0A3Q2UID3
uniprot id: A0A5P9VLA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9031:IL2
gene id: 9031:IL2
uniprot id: O42288
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9031:AFF3
gene id: 9031:AFF3
uniprot id: A0A1D5P1M2
names: Similarity
messages: Belongs to the AF4 family.

9031:BSX
gene id: 9031:BSX
uniprot id: Q6RFL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain.
messages: Nucleus

9031:GNB4
gene id: 9031:GNB4
uniprot id: E1BW98
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9031:TBP
gene id: 9031:TBP
uniprot id: O13270
uniprot id: Q6JLB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBP family.
messages: Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.
messages: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
messages: Nucleus

9031:MIB2
gene id: 9031:MIB2
uniprot id: Q5ZIJ9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

9031:LAPTM5
gene id: 9031:LAPTM5
uniprot id: A0A1D5PS13
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9031:TTC4
gene id: 9031:TTC4
uniprot id: A0A3Q2TU15
names: Similarity
messages: Belongs to the TTC4 family.

9031:TRAF3
gene id: 9031:TRAF3
uniprot id: A0A3Q2UB30
uniprot id: A0A3Q2UF43
uniprot id: A0A3Q3AAA5
uniprot id: E1BW11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9031:IGFBP1
gene id: 9031:IGFBP1
uniprot id: Q6PN72
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:TLCD2
gene id: 9031:TLCD2
uniprot id: F1P1C2
names: Subcellular Location Annotation
messages: Membrane

9031:MRPL15
gene id: 9031:MRPL15
uniprot id: Q5ZKT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9031:ISL2
gene id: 9031:ISL2
uniprot id: A0A1D5PRU8
names: Subcellular Location Annotation
messages: Nucleus

9031:CCSER1
gene id: 9031:CCSER1
uniprot id: A0A1D5PLD1
names: Similarity
messages: Belongs to the CCSER family.

9031:LOC107054771
gene id: 9031:LOC107054771
uniprot id: A0A1L1RTB6
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

9031:KYAT3
gene id: 9031:KYAT3
uniprot id: E1C934
names: Subunit
messages: Homodimer.

9031:MAN2A1
gene id: 9031:MAN2A1
uniprot id: A0A3Q2UIM7
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9031:ANO5
gene id: 9031:ANO5
uniprot id: F1NN74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

9031:CDH9
gene id: 9031:CDH9
uniprot id: E1C264
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9031:FDX1
gene id: 9031:FDX1
uniprot id: P13216
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenodoxin/putidaredoxin family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons.
messages: Mitochondrion matrix

9031:CD14
gene id: 9031:CD14
uniprot id: A0A1D5PJ49
uniprot id: B0BL87
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

9031:PKD1
gene id: 9031:PKD1
uniprot id: F1N838
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:USP10
gene id: 9031:USP10
uniprot id: Q5ZJN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity).
messages: Nucleus

9031:ART1L1
gene id: 9031:ART1L1
uniprot id: Q49L21
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:SLC16A2
gene id: 9031:SLC16A2
uniprot id: A0A142EGP9
names: Subcellular Location Annotation
messages: Membrane

9031:GABRA2
gene id: 9031:GABRA2
uniprot id: F1NXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9031:DSC1
gene id: 9031:DSC1
uniprot id: F1NJD7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9031:F2R
gene id: 9031:F2R
uniprot id: F1NM53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:MGST1
gene id: 9031:MGST1
uniprot id: B4X9P5
uniprot id: F1NT14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9031:LOC771456
gene id: 9031:LOC771456
uniprot id: U3NEE3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
messages: Monomer.
messages: N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles.
messages: Two different proteins belonging to two different protein families are able to mediate carnosine N-methyltransferase activity in chicken. This protein, which is not conserved in mammals, and another protein (AC F1N9S8), which is conserved from human to yeast.

9031:GRK3
gene id: 9031:GRK3
uniprot id: A0A1D5PP79
uniprot id: A0A3Q3A726
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9031:HACD1
gene id: 9031:HACD1
uniprot id: F1NL16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:FOXN2
gene id: 9031:FOXN2
uniprot id: F1NV54
names: Subcellular Location Annotation
messages: Nucleus

9031:B4GALNT3
gene id: 9031:B4GALNT3
uniprot id: F1NN69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

9031:ARCN1
gene id: 9031:ARCN1
uniprot id: Q5ZL57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

9031:SAR1A
gene id: 9031:SAR1A
uniprot id: F1NT40
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

9031:PQLC2L
gene id: 9031:PQLC2L
uniprot id: E1C8D5
names: Subcellular Location Annotation
messages: Membrane

9031:WEE1
gene id: 9031:WEE1
uniprot id: Q5F400
uniprot id: R4GJW5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9031:HIRA
gene id: 9031:HIRA
uniprot id: A0A1D5PZQ0
uniprot id: P79987
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat HIR1 family.
messages: Cooperates with ASF1A to promote replication-independent chromatin assembly (By similarity). May regulate the transcription of a variety of genes controlling cell growth.
messages: Expressed from gastrulation onwards with predominant expression in the neuroepithelium during neurulation. Expressed in regions of the embryo containing migrating neural crest cells, particularly those emanating from rhombomeres 4 and 6. Expressed throughout the rostral mesenchyme with higher levels of expression in regions containing neural crest cells. At later stages strong expression is seen in the neural crest derived regions of the head, the branchial arches and the pharyngeal pouches. Expression at the rhombomere boundaries increases around stage 16.
messages: Interacts with ASF1, HDAC1, HDAC2 and RBBP4.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

9031:DERL1
gene id: 9031:DERL1
uniprot id: Q5ZMF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9031:ROR1
gene id: 9031:ROR1
uniprot id: F1NML5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:FGFR1
gene id: 9031:FGFR1
uniprot id: P21804
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer and proceeds in a highly ordered manner. Phosphotyrosine residues provide docking sites for interacting proteins and so are crucial for FGFR1 function and its regulation (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Monomer. Homodimer after ligand binding (By similarity).
messages: N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus (By similarity).
messages: Nucleus
messages: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by sequential autophosphorylation on tyrosine residues (By similarity).
messages: The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Isoforms lacking the first Ig-like domain have higher affinity for fibroblast growth factors (FGF) and heparan sulfate proteoglycans than isoforms with all three Ig-like domains (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity).
messages: Ubiquitinated. FGFR1 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation (By similarity).
messages: cytosol

9031:SNF8
gene id: 9031:SNF8
uniprot id: E1BZH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

9031:CDH2
gene id: 9031:CDH2
uniprot id: P10288
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (PubMed:2831236). Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).
messages: Cell junction
messages: Cell membrane
messages: Cell surface
messages: Detected in embryonic brain and heart (at protein level) (PubMed:1638632). Detected in embryonic brain and heart (PubMed:2831236).
messages: Homodimer (via extracellular region). Can also form heterodimers with other cadherins (via extracellular region). Dimerization occurs in trans, i.e. with a cadherin chain from another cell (By similarity). Interacts with CTNNA2 (PubMed:1638632).
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1.
messages: adherens junction
messages: desmosome
messages: sarcolemma

9031:SYNDIG1
gene id: 9031:SYNDIG1
uniprot id: A0A1D5NTZ6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9031:SRP9
gene id: 9031:SRP9
uniprot id: Q5ZHT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9031:SLC7A5
gene id: 9031:SLC7A5
uniprot id: Q5ZIJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

9031:UGT8
gene id: 9031:UGT8
uniprot id: Q98TB5
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9031:ZNF706
gene id: 9031:ZNF706
uniprot id: Q5ZMM5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal.

9031:TTYH1
gene id: 9031:TTYH1
uniprot id: R4GGQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9031:TRAPPC6A
gene id: 9031:TRAPPC6A
uniprot id: E1C3X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9031:HSP90AB1
gene id: 9031:HSP90AB1
uniprot id: F1NC33
uniprot id: Q04619
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: In contrast to other HSP90 heat shock proteins, this one is not induced by heat shock or mitogenic stimuli but is strictly constitutive.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Melanosome
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle.
messages: Monomer. Homodimer.
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.

9031:PCDHGC3
gene id: 9031:PCDHGC3
uniprot id: O13129
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9031:ELOVL3
gene id: 9031:ELOVL3
uniprot id: E7E8G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

9031:DUS4L
gene id: 9031:DUS4L
uniprot id: F1NHN2
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9031:CD55
gene id: 9031:CD55
uniprot id: A0A3Q2ULT8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:MTFP1
gene id: 9031:MTFP1
uniprot id: A0A1D5P0R4
names: Similarity
messages: Belongs to the MTFP1 family.

9031:NEO1
gene id: 9031:NEO1
uniprot id: A0A3Q2UG48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9031:IPMK
gene id: 9031:IPMK
uniprot id: F1NFX3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9031:HSD17B2
gene id: 9031:HSD17B2
uniprot id: E1C6C8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:NSMCE4A
gene id: 9031:NSMCE4A
uniprot id: F1NV66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

9031:ITFG1
gene id: 9031:ITFG1
uniprot id: Q5ZL76
names: Similarity
messages: Belongs to the TIP family.

9031:HEATR5B
gene id: 9031:HEATR5B
uniprot id: E1C8J1
names: Similarity
messages: Belongs to the HEATR5 family.

9031:MRPS9
gene id: 9031:MRPS9
uniprot id: A0A1D5P607
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9031:LRRFIP1
gene id: 9031:LRRFIP1
uniprot id: A0A3Q2U8A7
names: Similarity
messages: Belongs to the LRRFIP family.

9031:TSSC1
gene id: 9031:TSSC1
uniprot id: Q5ZIB3
names: Similarity
messages: Belongs to the WD repeat EIPR1 family.

9031:OPNVA
gene id: 9031:OPNVA
uniprot id: A7M6L0
uniprot id: A8QJE7
uniprot id: D0E2W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9031:SKOR2
gene id: 9031:SKOR2
uniprot id: A0A3Q2TW98
names: Similarity
messages: Belongs to the SKI family.

9031:CYP39A1
gene id: 9031:CYP39A1
uniprot id: A0A3Q3A5J9
uniprot id: E1BWN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9031:SLC25A21
gene id: 9031:SLC25A21
uniprot id: A0A1L1RWY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:MNX1
gene id: 9031:MNX1
uniprot id: Q9YHY7
names: Subcellular Location Annotation
messages: Nucleus

9031:TPM3
gene id: 9031:TPM3
uniprot id: H9L074
uniprot id: H9L3K0
uniprot id: Q5ZLJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9031:CNOT2
gene id: 9031:CNOT2
uniprot id: Q5ZKI3
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9031:NEURL2
gene id: 9031:NEURL2
uniprot id: F1NIQ8
names: Subcellular Location Annotation
messages: Cytoplasm

9031:GAP43
gene id: 9031:GAP43
uniprot id: P35001
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neuromodulin family.
messages: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Cell membrane
messages: Expressed in neurons.
messages: First expressed in the body and head at embryonic stage 3 dpc (PubMed:2153895). Expressed in the mid-thoracic region of embryos and also in the spinal cord, dorsal root and sympathetic ganglia at embryonic stage 10 dpc (PubMed:2153895). Highly expressed in the brain at embryonic stage 13 dpc (PubMed:2153895). Expressed at low levels in the gut at embryonic stage 16 dpc (PubMed:2153895). Not expressed in heart, skeletal muscle or liver at embryonic stage 16 dpc (PubMed:2153895).
messages: Palmitoylated (PubMed:9813098). Palmitoylation is essential for plasma membrane association (PubMed:9813098).
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).
messages: filopodium membrane
messages: growth cone membrane

9031:DFNA5
gene id: 9031:DFNA5
uniprot id: F1NP12
uniprot id: Q5ZJ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9031:CXorf23
gene id: 9031:CXorf23
uniprot id: F1NKX9
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9031:PDIA4
gene id: 9031:PDIA4
uniprot id: Q5ZK20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9031:MGAT4C
gene id: 9031:MGAT4C
uniprot id: Q9DGD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 54 family.
messages: Glycosyltransferase that catalyzes the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage (also named 'GnT-VI' activity). May also participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans by catalyzing the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans.
messages: Golgi apparatus membrane
messages: Highly expressed in oviduct, spleen, lung and colon.

9031:TRAPPC5
gene id: 9031:TRAPPC5
uniprot id: Q5F359
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

9031:MYL12A
gene id: 9031:MYL12A
uniprot id: P24032
names: Function
names: Miscellaneous
names: PTM
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).
messages: Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity.
messages: This chain binds calcium.

9031:GNAI1
gene id: 9031:GNAI1
uniprot id: P50146
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity).
messages: Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Part of a spindle orientation complex. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG1. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG2. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins (By similarity).
messages: Membrane
messages: Myristoylation at Gly-2 is required for membrane anchoring before palmitoylation.
messages: Nucleus
messages: Palmitoylation at Cys-3 varies with membrane lipid composition.
messages: cell cortex
messages: centrosome

9031:MTMR2
gene id: 9031:MTMR2
uniprot id: Q5ZIV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Early endosome membrane
messages: Homooligomer and heterooligomer.
messages: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).

9031:GAREM2
gene id: 9031:GAREM2
uniprot id: A0A3Q2TSB5
names: Similarity
messages: Belongs to the GAREM family.

9031:PDLIM1
gene id: 9031:PDLIM1
uniprot id: A0A1D5NU14
uniprot id: E1C852
names: Subcellular Location Annotation
messages: Z line

9031:AIMP2
gene id: 9031:AIMP2
uniprot id: F1NSQ1
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9031:UCK1
gene id: 9031:UCK1
uniprot id: F1NN92
names: Similarity
messages: Belongs to the uridine kinase family.

9031:MX1
gene id: 9031:MX1
uniprot id: B2X026
uniprot id: Q90597
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By interferons.
messages: Cytoplasm
messages: Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus.

9031:CPT1A
gene id: 9031:CPT1A
uniprot id: Q6B842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:TMPRSS2
gene id: 9031:TMPRSS2
uniprot id: F1NY88
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:COLEC10
gene id: 9031:COLEC10
uniprot id: Q2LK95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the COLEC10/COLEC11 family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration.
messages: Secreted
messages: Widely expressed. Highly expressed in lung. Weakly expressed in larynx, syrinx and cranial air sac. Expressed throughout the lower gastrointestinal tract in increasing levels starting from a faint signal in duodenum and ending with relatively high signals in proctodeum, coprodeum and urodeum. In the upper part of the gastrointestinal tract, expressed in tongue, crop, and mucosa of the crop.

9031:MYOZ3
gene id: 9031:MYOZ3
uniprot id: A0A3Q2TYR0
names: Similarity
messages: Belongs to the myozenin family.

9031:MAN1A1
gene id: 9031:MAN1A1
uniprot id: F1N9D0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9031:NGLY1
gene id: 9031:NGLY1
uniprot id: Q5ZJM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity).

9031:SEC11A
gene id: 9031:SEC11A
uniprot id: Q5ZMQ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:B2M
gene id: 9031:B2M
uniprot id: P21611
uniprot id: Q6L753
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.
messages: Secreted

9031:DDX59
gene id: 9031:DDX59
uniprot id: A0A3Q2UA43
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

9031:FAM49A
gene id: 9031:FAM49A
uniprot id: A0A1D5PP47
uniprot id: Q5ZI04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: May negatively regulate RAC1 signaling and RAC1-driven cytoskeletal remodeling. May regulate chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions.
messages: Membrane

9031:NDUFAF1
gene id: 9031:NDUFAF1
uniprot id: E1BZH1
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

9031:TMEM198
gene id: 9031:TMEM198
uniprot id: H9L154
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9031:DNM1L
gene id: 9031:DNM1L
uniprot id: A0A3Q2UHM4
uniprot id: A0A3Q3ACH0
uniprot id: Q5F469
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

9031:IDH1
gene id: 9031:IDH1
uniprot id: F1NPG2
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9031:NBN
gene id: 9031:NBN
uniprot id: Q9DE07
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity (PubMed:12422221). The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis (PubMed:12422221). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (By similarity). RAD50 may be required to bind DNA ends and hold them in close proximity (By similarity). NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions (By similarity). It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX (By similarity). NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation (By similarity). NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints (By similarity). The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability (By similarity). Forms a complex with RBBP8 to link DNA double-strand break sensing to resection (By similarity).
messages: Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN. Interacts with RBBP8; the interaction links the role of the MRN complex in DNA double-strand break sensing to resection.
messages: Nucleus
messages: Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and telomere maintenance.
messages: The C-terminal domain contains a MRE11-binding site, and this interaction is required for the nuclear localization of the MRN complex.
messages: The EEXXXDDL motif at the C-terminus is required for the interaction with ATM and its recruitment to sites of DNA damage and promote the phosphorylation of ATM substrates, leading to the events of DNA damage response.
messages: The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AX and for relocalization of MRE11/RAD50 complex to the vicinity of DNA damage.
messages: telomere

9031:CALD1
gene id: 9031:CALD1
uniprot id: P12957
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping.
messages: Belongs to the caldesmon family.
messages: High-molecular-weight caldesmon (h-caldesmon) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (l-caldesmon) is widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
messages: Phosphorylated in non-muscle cells. Phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization (By similarity).
messages: The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the muscle forms.
messages: cytoskeleton
messages: myofibril
messages: stress fiber

9031:HINT2
gene id: 9031:HINT2
uniprot id: Q9I882
names: Similarity
messages: Belongs to the HINT family.

9031:TFEC
gene id: 9031:TFEC
uniprot id: Q5XFQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus
messages: Transcriptional regulator that acts as a repressor or an activator. Binds DNA (By similarity).

9031:PARD6A
gene id: 9031:PARD6A
uniprot id: F1P0U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9031:MZT2B
gene id: 9031:MZT2B
uniprot id: A0A1D5NZK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

9031:DIS3L
gene id: 9031:DIS3L
uniprot id: F1NKN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNR ribonuclease family.
messages: Cytoplasm

9031:GTPBP1
gene id: 9031:GTPBP1
uniprot id: A0A1D5P2N4
names: Function
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

9031:DYNC1I2
gene id: 9031:DYNC1I2
uniprot id: Q5ZK94
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9031:PANX1
gene id: 9031:PANX1
uniprot id: A0A1D5P0I0
uniprot id: A0A1D5PP45
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9031:DISP3
gene id: 9031:DISP3
uniprot id: B9U3F2
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the patched family.
messages: Cytoplasmic vesicle membrane
messages: Down-regulated by thyroid hormone T3 in retinal ganglion layers during the embryonic development (PubMed:19179482).
messages: Endoplasmic reticulum membrane
messages: Expressed in retina, hippocampus and cerebellum (PubMed:19179482). Expressed in the ganglion and bipolar cells of the inner and outer nuclear layers of the retina and in Purkinje cells (at protein level) (PubMed:19179482). Expressed strongly in brain and retina, weakly in testis and bone marrow (PubMed:19179482).
messages: Nucleus membrane
messages: Plays a role in neuronal proliferation and differentiation (By similarity). Plays a role in the accumulation of cellular cholesterol (PubMed:19179482). Involved in intracellular lipid droplet formation (PubMed:19179482). May contribute to cholesterol homeostasis in neuronal cells (PubMed:19179482).
messages: The SSD (sterol-sensing) domain is necessary for the increase in cellular cholesterol uptake (PubMed:19179482).

9031:EIF2B5
gene id: 9031:EIF2B5
uniprot id: E1BXS9
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9031:GRPR
gene id: 9031:GRPR
uniprot id: Q802E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:GFAP
gene id: 9031:GFAP
uniprot id: F1NE70
names: Similarity
messages: Belongs to the intermediate filament family.

9031:TTC25
gene id: 9031:TTC25
uniprot id: E1C1J4
names: Subcellular Location Annotation
messages: cilium axoneme

9031:MAPK3
gene id: 9031:MAPK3
uniprot id: Q8UWG6
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9031:PLCZ1
gene id: 9031:PLCZ1
uniprot id: Q2VRL0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed specifically in testis.
messages: Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
messages: Nucleus
messages: The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity.
messages: The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

9031:CHMP2B
gene id: 9031:CHMP2B
uniprot id: Q5F3A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).
messages: cytosol

9031:TOP3A
gene id: 9031:TOP3A
uniprot id: A0A1D5P0H8
uniprot id: Q4W5X0
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9031:ZBTB8OS
gene id: 9031:ZBTB8OS
uniprot id: F1NMM3
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

9031:MRPS17
gene id: 9031:MRPS17
uniprot id: E1C9H4
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9031:PTPN1
gene id: 9031:PTPN1
uniprot id: A0A3Q3AWY5
uniprot id: O13016
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.
messages: Endoplasmic reticulum membrane
messages: May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity).
messages: Phosphorylated on serine and threonine residues near the N-terminus by casein kinase II (CK2).

9031:ABCD3
gene id: 9031:ABCD3
uniprot id: Q5F4B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

9031:UPP1
gene id: 9031:UPP1
uniprot id: E1C1T2
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9031:CYP2J23
gene id: 9031:CYP2J23
uniprot id: A0A1L1RVS8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:F5
gene id: 9031:F5
uniprot id: A0A1D5P5L2
names: Similarity
messages: Belongs to the multicopper oxidase family.

9031:PPP6R3
gene id: 9031:PPP6R3
uniprot id: A0A3Q2U7F4
uniprot id: Q5F471
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SAPS family.
messages: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).
messages: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit (By similarity).

9031:MORF4L2
gene id: 9031:MORF4L2
uniprot id: A0A3Q2TT47
uniprot id: F1P0X1
names: Subcellular Location Annotation
messages: Nucleus

9031:NRF1
gene id: 9031:NRF1
uniprot id: A0A3Q2U3T8
uniprot id: Q90979
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9031:COL14A1
gene id: 9031:COL14A1
uniprot id: P32018
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors.
messages: Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
messages: Homotrimer.
messages: Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all cases and bind carbohydrates.
messages: May contain numerous cysteine residues involved in inter- and intramolecular disulfide bonding.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: Wide tissue distribution; high presence in dense connective tissue in skeletal muscle.
messages: extracellular matrix

9031:PLK2
gene id: 9031:PLK2
uniprot id: F1NB57
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9031:ITGA4
gene id: 9031:ITGA4
uniprot id: A0A1D5PKL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9031:BRE
gene id: 9031:BRE
uniprot id: Q5ZML0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: Nucleus

9031:NEFH
gene id: 9031:NEFH
uniprot id: F1ND22
names: Similarity
messages: Belongs to the intermediate filament family.

9031:GCM1
gene id: 9031:GCM1
uniprot id: F1NQZ7
uniprot id: Q6UEJ0
names: Subcellular Location Annotation
messages: Nucleus

9031:LOC776018
gene id: 9031:LOC776018
uniprot id: A0A3Q2UDL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:PNRC2
gene id: 9031:PNRC2
uniprot id: Q5ZMB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
messages: Nucleus
messages: P-body

9031:NFS1
gene id: 9031:NFS1
uniprot id: Q5ZKP5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9031:DPYSL3
gene id: 9031:DPYSL3
uniprot id: A0A1D5PZ51
uniprot id: Q71SF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
messages: growth cone

9031:SFXN3
gene id: 9031:SFXN3
uniprot id: A0A3Q2U0F7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9031:NAT9
gene id: 9031:NAT9
uniprot id: A0A1D5PI17
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

9031:NDUFA10
gene id: 9031:NDUFA10
uniprot id: Q5ZIQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

9031:ZNF622
gene id: 9031:ZNF622
uniprot id: A0A1D5PB45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9031:IPPK
gene id: 9031:IPPK
uniprot id: E1BV79
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9031:IER3IP1
gene id: 9031:IER3IP1
uniprot id: A0A1D5PTS3
names: Similarity
messages: Belongs to the YOS1 family.

9031:AGTR2
gene id: 9031:AGTR2
uniprot id: F1NC23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

9031:NKX6-2
gene id: 9031:NKX6-2
uniprot id: A0A3Q2UGY9
names: Subcellular Location Annotation
messages: Nucleus

9031:C21orf59
gene id: 9031:C21orf59
uniprot id: Q5ZIK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

9031:RRM1
gene id: 9031:RRM1
uniprot id: Q5ZM69
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9031:ZW10
gene id: 9031:ZW10
uniprot id: A0A1D5PLU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

9031:ACVR1C
gene id: 9031:ACVR1C
uniprot id: A0A3Q2TUT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9031:FADS2
gene id: 9031:FADS2
uniprot id: A6NAB8
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

9031:SCN11A
gene id: 9031:SCN11A
uniprot id: F9W2X9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9031:RBBP5
gene id: 9031:RBBP5
uniprot id: Q5ZLX3
names: Subcellular Location Annotation
messages: Nucleus

9031:CDKL1
gene id: 9031:CDKL1
uniprot id: E1C5K5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:XPO4
gene id: 9031:XPO4
uniprot id: Q5ZMR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Mediates the nuclear export of proteins (cargos) with broad substrate specificity.
messages: Nucleus

9031:CFI
gene id: 9031:CFI
uniprot id: F1NF64
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:XKR5
gene id: 9031:XKR5
uniprot id: A0A1L1S0R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9031:CHRM4
gene id: 9031:CHRM4
uniprot id: A0A3Q2UA34
uniprot id: F1NVL7
uniprot id: P17200
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
messages: Cell membrane
messages: Expressed in heart and brain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. May couple to multiple functional responses in cell lines.

9031:EBF3
gene id: 9031:EBF3
uniprot id: A0A1D5PHG6
uniprot id: A0A1D5PTC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9031:RPS11
gene id: 9031:RPS11
uniprot id: Q98TH5
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9031:PMM2
gene id: 9031:PMM2
uniprot id: Q5ZJ50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9031:CTSH
gene id: 9031:CTSH
uniprot id: F5CE71
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:GRHL1
gene id: 9031:GRHL1
uniprot id: A0A1D5NZ26
uniprot id: A0A1D5PX42
names: Subcellular Location Annotation
messages: Nucleus

9031:AFMID
gene id: 9031:AFMID
uniprot id: E1C2H6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

9031:TXNDC5
gene id: 9031:TXNDC5
uniprot id: Q5ZIM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9031:MAN1C1
gene id: 9031:MAN1C1
uniprot id: F1P0Z9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9031:MYH15
gene id: 9031:MYH15
uniprot id: F1NM49
uniprot id: Q9IBD4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:APOC3
gene id: 9031:APOC3
uniprot id: A0A1D5PK48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

9031:ZDHHC17
gene id: 9031:ZDHHC17
uniprot id: Q5ZIM1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:CYP2J21
gene id: 9031:CYP2J21
uniprot id: A0A1D5PZZ1
uniprot id: Q5ZHU7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:RPL5
gene id: 9031:RPL5
uniprot id: P22451
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53.
messages: Cytoplasm
messages: nucleolus

9031:MAFIP
gene id: 9031:MAFIP
uniprot id: E1C2N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

9031:THT2L
gene id: 9031:THT2L
uniprot id: A0A3Q2UH29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9031:AQP9
gene id: 9031:AQP9
uniprot id: A0A1D5PEK7
uniprot id: A7VMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:PBX1
gene id: 9031:PBX1
uniprot id: F1NQJ4
uniprot id: Q9IB15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9031:PARP1
gene id: 9031:PARP1
uniprot id: F1NL05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.

9031:MRPL20
gene id: 9031:MRPL20
uniprot id: E1BRV2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

9031:NIT1
gene id: 9031:NIT1
uniprot id: A0A1D5P5R1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9031:ATP5O
gene id: 9031:ATP5O
uniprot id: A0A1D5P810
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9031:AVP
gene id: 9031:AVP
uniprot id: P24787
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasopressin/oxytocin family.
messages: Secreted
messages: Seven disulfide bonds are present in neurophysin.
messages: Vasotocin is an antidiuretic hormone.

9031:DUSP6
gene id: 9031:DUSP6
uniprot id: Q7T2L9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9031:CCNB3
gene id: 9031:CCNB3
uniprot id: A0A1L1RLD1
uniprot id: P39963
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
messages: Interacts with the CDK1 and CDK2 protein kinases.
messages: Nucleus
messages: The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: Ubiquitinated, leading to its degradation.

9031:STEAP2
gene id: 9031:STEAP2
uniprot id: E1BTX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9031:S1PR3
gene id: 9031:S1PR3
uniprot id: A0A3Q2U344
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:PRTG
gene id: 9031:PRTG
uniprot id: Q589G5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Highest expression is found in E1-E3 embryos with a significant decrease after 3.5 dpc.
messages: In the embryo, expressed in early mesodermal cells, the neuroepithelial layer of the brain and the trunk neural tube, the neural layer of the retina and in the epithelial somite and dermomyotome. From mid-gastrulation to early somite stages, restricted to the posterior embryonic region but this posterior restriction is progressively lost during somitogenesis. As development proceeds, further restricted to the dorsal parts of the spinal cord and somites. In parallel, expression progresses caudally during axis elongation.
messages: May play a role in anteroposterior axis elongation.
messages: Membrane

9031:TPST1
gene id: 9031:TPST1
uniprot id: E1C200
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9031:ELOVL5
gene id: 9031:ELOVL5
uniprot id: E3VVZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: dendrite

9031:ERAL1
gene id: 9031:ERAL1
uniprot id: Q8JIF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).

9031:FLT1
gene id: 9031:FLT1
uniprot id: Q8QHL3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues upon ligand binding.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Endosome
messages: Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB and PGF (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFB or PGF leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: Secreted
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates PLCG1. Promotes phosphorylation of AKT1 and CBL (By similarity).

9031:MAP3K14
gene id: 9031:MAP3K14
uniprot id: F1NMZ5
uniprot id: Q5F350
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9031:FAM163B
gene id: 9031:FAM163B
uniprot id: R4GL56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

9031:CKS1B
gene id: 9031:CKS1B
uniprot id: A0A1L1S0Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9031:FAXC
gene id: 9031:FAXC
uniprot id: E1C3J5
names: Similarity
messages: Belongs to the FAX family.

9031:SNRPE
gene id: 9031:SNRPE
uniprot id: P62303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9031:LOC768416
gene id: 9031:LOC768416
uniprot id: A0A1D5NYQ6
uniprot id: Q5ZI53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9031:AvBD7
gene id: 9031:AvBD7
uniprot id: Q6QLR2
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Detected in the theca and granulosa layers of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages.
messages: Has bactericidal activity.
messages: Induced in the theca layer of the F3 stage ovarian follicle by intravenous injection of LPS. Expression in the kidney and liver is not affected by intravenous injection of LPS.
messages: Secreted
messages: Strong expression in the bone marrow and testis. Expressed in the ovarian stroma and the theca layer of the ovarian follicles. Not expressed in the granulosa layer of the ovarian follicles.

9031:TPD52L1
gene id: 9031:TPD52L1
uniprot id: A0A1D5P1I7
uniprot id: Q9I8F4
names: Similarity
names: Subunit
messages: Belongs to the TPD52 family.
messages: Forms a homodimer or heterodimer with other members of the family.

9031:IGF1
gene id: 9031:IGF1
uniprot id: C5J073
uniprot id: P18254
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.

9031:STAC
gene id: 9031:STAC
uniprot id: A0A1D5P8F5
names: Subcellular Location Annotation
messages: sarcolemma

9031:MRPS7
gene id: 9031:MRPS7
uniprot id: Q5ZMU0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

9031:SRP54
gene id: 9031:SRP54
uniprot id: E1C6G6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle
messages: Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits.

9031:METTL16
gene id: 9031:METTL16
uniprot id: Q5ZIA0
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Methyltransferase activity is autoinhibited by the K-loop region that blocks S-adenosyl-L-methionine-binding. Upon activation, K-loop changes conformation, allowing S-adenosyl-L-methionine-binding and subsequent methyltransferase activity. mRNA N6-adenosine-methyltransferase activity is inhibited by zinc.
messages: Nucleus
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A splicing and protein expression. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs.
messages: The K-loop region occludes the S-adenosyl-L-methionine-binding pocket. Upon activation, conformation of the K-loop changes, allowing S-adenosyl-L-methionine-binding.
messages: The VCR (vertebrate conserved) regions bind the first hairpin of MAT2A mRNAs. The VCR regions interact with the internal stem-loop within U6 snRNAs, inducing the conformational rearrangement of the A43-containing region of U6 snRNA, thereby modifying the RNA structure to become suitable for productive catalysis by the methyltransferase region.

9031:TGM2
gene id: 9031:TGM2
uniprot id: Q01841
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acyltransferase activity is regulated by the binding of GTP and Ca(2+): inactivated by GTP, which stabilizes its closed structure, thereby obstructing the accessibility of substrates to the active sites. In contrast, Ca(2+) acts as a cofactor by inducing conformational change to the active open form. In absence of Ca(2+), Mg(2+) may bind Ca(2+)-binding sites, promoting GTP-binding and subsequent inhibition of the acyltransferase activity.
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins: under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, resulting in the formation of scaffolds. Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components. In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (By similarity). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3. Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, …
messages: Cell membrane
messages: Chromosome
messages: Mitochondrion
messages: Monomer.
messages: Nucleus
messages: Predominates in mature erythrocytes. Also found in kidney and cardiac muscle.
messages: cytosol
messages: extracellular matrix

9031:TRABD2B
gene id: 9031:TRABD2B
uniprot id: R4GF39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9031:WDFY2
gene id: 9031:WDFY2
uniprot id: A0A1D5NTA7
uniprot id: Q5ZL44
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9031:SLC19A1
gene id: 9031:SLC19A1
uniprot id: Q5ZMS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: Transporter that mediates the import of reduced folates.

9031:CNTF
gene id: 9031:CNTF
uniprot id: Q02011
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm
messages: Nervous system.

9031:FAM46C
gene id: 9031:FAM46C
uniprot id: Q5ZL95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TENT family.
messages: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression.
messages: Cytoplasm
messages: Nucleus
messages: centrosome

9031:LOC100858177
gene id: 9031:LOC100858177
uniprot id: P42165
uniprot id: Q38IF1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears first at 3 hours post-infection, increases to give the strongest signal at about 9 hours and gradually wanes to almost nothing at 24 hours.
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:JMY
gene id: 9031:JMY
uniprot id: E1C822
names: Subcellular Location Annotation
messages: Membrane

9031:RBM10
gene id: 9031:RBM10
uniprot id: Q5F3M2
names: Subcellular Location Annotation
messages: Nucleus

9031:PRKAB2
gene id: 9031:PRKAB2
uniprot id: Q156C5
uniprot id: Q156C7
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9031:HIST1H2A4
gene id: 9031:HIST1H2A4
uniprot id: P02263
uniprot id: Q92069
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AK119Ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties, leading to the recruitment of repair proteins to sites of DNA damage. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:GRIA3
gene id: 9031:GRIA3
uniprot id: Q90857
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:GPC1
gene id: 9031:GPC1
uniprot id: F1P150
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: extracellular space

9031:BMPR1A
gene id: 9031:BMPR1A
uniprot id: F1P3H0
uniprot id: Q90754
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9031:AGRP
gene id: 9031:AGRP
uniprot id: Q9W7R0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:NR1I3
gene id: 9031:NR1I3
uniprot id: Q9DFH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

9031:KIAA1191
gene id: 9031:KIAA1191
uniprot id: A0A3Q2U0F5
uniprot id: Q5F368
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity).

9031:MELK
gene id: 9031:MELK
uniprot id: Q5ZL85
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9031:RPRD1B
gene id: 9031:RPRD1B
uniprot id: Q5F4B4
names: Similarity
messages: Belongs to the UPF0400 (RTT103) family.

9031:APOA4
gene id: 9031:APOA4
uniprot id: O93601
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9031:EFTUD2
gene id: 9031:EFTUD2
uniprot id: Q5F3X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). Component of the pre-catalytic, catalytic and post-catalytic spliceosome complexes (By similarity).
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity).

9031:ASCC1
gene id: 9031:ASCC1
uniprot id: A0A1D5PKQ5
names: Subcellular Location Annotation
messages: Cytoplasm

9031:HIST1H46
gene id: 9031:HIST1H46
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:RBM3
gene id: 9031:RBM3
uniprot id: A0A3Q3AZJ6
uniprot id: Q45KQ2
uniprot id: Q5ZLU8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm

9031:BARX2
gene id: 9031:BARX2
uniprot id: Q9W694
names: Subcellular Location Annotation
messages: Nucleus

9031:SNAP47
gene id: 9031:SNAP47
uniprot id: A0A3Q2TZN1
uniprot id: F1NX76
names: Similarity
messages: Belongs to the SVAP1 family.

9031:TUBGCP5
gene id: 9031:TUBGCP5
uniprot id: F1NEV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

9031:PRLL
gene id: 9031:PRLL
uniprot id: C6ZDB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9031:IFIH1
gene id: 9031:IFIH1
uniprot id: D9N195
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9031:SPON2
gene id: 9031:SPON2
uniprot id: A0A1D5PVD0
uniprot id: A0A3Q2TRX4
names: Subcellular Location Annotation
messages: extracellular matrix

9031:EREG
gene id: 9031:EREG
uniprot id: Q6PSS9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GBP1
gene id: 9031:GBP1
uniprot id: F1N9J3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9031:NEGR1
gene id: 9031:NEGR1
uniprot id: Q9W6V2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. IgLON family.
messages: Cell membrane
messages: Expressed in embryonic retina, telencephalon, tectum, cerebellum and diencephalon (at protein level).
messages: Glycosylated.
messages: Interacts with CEPU-1 and LAMP.
messages: May be involved in cell-adhesion. May participate in the regulation of neurite outgrowth in the developing brain.

9031:FOXN4
gene id: 9031:FOXN4
uniprot id: A3EYS4
names: Subcellular Location Annotation
messages: Nucleus

9031:TPPP3
gene id: 9031:TPPP3
uniprot id: E1BR14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

9031:MANEA
gene id: 9031:MANEA
uniprot id: F1NWI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:PREP
gene id: 9031:PREP
uniprot id: Q5ZMI7
names: Similarity
messages: Belongs to the peptidase S9A family.

9031:SUPV3L1
gene id: 9031:SUPV3L1
uniprot id: Q5ZJT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: mitochondrion nucleoid

9031:CPA5
gene id: 9031:CPA5
uniprot id: F1NWB2
names: Similarity
messages: Belongs to the peptidase M14 family.

9031:MICAL1
gene id: 9031:MICAL1
uniprot id: Q5F3F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9031:AvBD6
gene id: 9031:AvBD6
uniprot id: Q6QLR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Expressed in bone marrow, testis, ovary, lung and trachea. Expressed in the ovarian stroma, but not in the ovarian follicles.
messages: Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis.
messages: Secreted

9031:MYH10
gene id: 9031:MYH10
uniprot id: Q02015
uniprot id: Q789A4
uniprot id: Q789A5
uniprot id: Q789A6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:BMP7
gene id: 9031:BMP7
uniprot id: F1NUT2
names: Similarity
messages: Belongs to the TGF-beta family.

9031:RAP2A
gene id: 9031:RAP2A
uniprot id: E1BQI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

9031:TSPO2
gene id: 9031:TSPO2
uniprot id: F1NNL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9031:TTLL8
gene id: 9031:TTLL8
uniprot id: A0A1D5P4Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:RAD52
gene id: 9031:RAD52
uniprot id: A0A1D5NXF5
names: Similarity
messages: Belongs to the RAD52 family.

9031:NMT1
gene id: 9031:NMT1
uniprot id: A0A1L1RKT0
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9031:LOC100859381
gene id: 9031:LOC100859381
uniprot id: F1NDD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:BEST1
gene id: 9031:BEST1
uniprot id: E1C3A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Membrane

9031:SENP1
gene id: 9031:SENP1
uniprot id: A0A1D5PIW4
uniprot id: A0A1D5PLQ6
names: Similarity
messages: Belongs to the peptidase C48 family.

9031:GNPTAB
gene id: 9031:GNPTAB
uniprot id: A0A1D5P8V5
uniprot id: E1BYC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

9031:SCFD2
gene id: 9031:SCFD2
uniprot id: A0A1D5NZ00
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9031:RAB5B
gene id: 9031:RAB5B
uniprot id: Q5ZHW4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Early endosome membrane
messages: Protein transport. Probably involved in vesicular traffic.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

9031:SS18L1
gene id: 9031:SS18L1
uniprot id: F1NW13
names: Similarity
messages: Belongs to the SS18 family.

9031:CRIM1
gene id: 9031:CRIM1
uniprot id: Q8AWW5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed at embryonic stage 20 in the notchcord and weakly in the foor plate and persist until stage 29. Expressed in the motor neuron pool at stage 23. At stage 26 and 29 highly expressed in the ventrolateral neural tube and also in the roof plate.
messages: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.
messages: Membrane

9031:LOC100857940
gene id: 9031:LOC100857940
uniprot id: A0A1D5P6V7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:AVL9
gene id: 9031:AVL9
uniprot id: A0A1D5P0R9
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

9031:UBE4A
gene id: 9031:UBE4A
uniprot id: Q5ZKF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9031:DYDC2
gene id: 9031:DYDC2
uniprot id: E1C7P1
names: Similarity
messages: Belongs to the dpy-30 family.

9031:ST6GALNAC5
gene id: 9031:ST6GALNAC5
uniprot id: F6VMN5
uniprot id: Q6ZXY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:SF3B5
gene id: 9031:SF3B5
uniprot id: A0A1D5P7U7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

9031:ENO1
gene id: 9031:ENO1
uniprot id: P51913
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Binds two Mg(2+) per subunit. Required for catalysis and for stabilizing the dimer.
messages: Cytoplasm
messages: Homodimer.

9031:HSPA13
gene id: 9031:HSPA13
uniprot id: F1ND59
uniprot id: Q5F497
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9031:PLAT
gene id: 9031:PLAT
uniprot id: E1C209
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:CDK14
gene id: 9031:CDK14
uniprot id: A0A3Q2U2B1
uniprot id: A0A3Q2U693
uniprot id: E1BS76
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:NES
gene id: 9031:NES
uniprot id: O57613
names: Similarity
messages: Belongs to the intermediate filament family.

9031:CALM1
gene id: 9031:CALM1
uniprot id: P05419
uniprot id: P62149
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

9031:ZFYVE26
gene id: 9031:ZFYVE26
uniprot id: R4GHN7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
messages: Midbody
messages: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

9031:HDGFRP2
gene id: 9031:HDGFRP2
uniprot id: A0A3Q2UF08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

9031:BMI1
gene id: 9031:BMI1
uniprot id: Q5SDR3
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a PRC1-like complex.
messages: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.
messages: Cytoplasm
messages: During early nervous system development, robust expression was observed in the open neural plate and later in the dorsal neural tube and much of the brain. Also present in the developing heart primordia and the sensory placodes.
messages: Nucleus

9031:LOC107051813
gene id: 9031:LOC107051813
uniprot id: A0A1D5P7Q2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:CHDH
gene id: 9031:CHDH
uniprot id: E1C003
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9031:TMEM50B
gene id: 9031:TMEM50B
uniprot id: A0A1L1RX69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9031:TCEANC2
gene id: 9031:TCEANC2
uniprot id: E1C1G6
names: Subcellular Location Annotation
messages: Nucleus

9031:RBP4A
gene id: 9031:RBP4A
uniprot id: P41263
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.
messages: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
messages: Secreted

9031:CDK3
gene id: 9031:CDK3
uniprot id: F1NA68
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:DDX10
gene id: 9031:DDX10
uniprot id: Q5ZJF6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
messages: Putative ATP-dependent RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9031:RBM38
gene id: 9031:RBM38
uniprot id: Q5ZJX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM38 family.
messages: Nucleus
messages: RNA-binding protein that specifically bind the 3'-UTR of some transcripts, leading to maintain their stability. Also acts as a mRNA splicing factor. May play a role in myogenic differentiation (By similarity).
messages: cytosol

9031:FABP6
gene id: 9031:FABP6
uniprot id: F1NUJ7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:HECTD1
gene id: 9031:HECTD1
uniprot id: E1C040
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

9031:RANBP10
gene id: 9031:RANBP10
uniprot id: F1NUL5
names: Similarity
messages: Belongs to the RANBP9/10 family.

9031:ADCK2
gene id: 9031:ADCK2
uniprot id: F1P1M5
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9031:HADHA
gene id: 9031:HADHA
uniprot id: F1NI29
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9031:SLC25A42
gene id: 9031:SLC25A42
uniprot id: A0A3Q3A649
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:DYL2
gene id: 9031:DYL2
uniprot id: E1C5T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9031:MAS1
gene id: 9031:MAS1
uniprot id: E1BVU0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:HIST1H2A4L3
gene id: 9031:HIST1H2A4L3
uniprot id: P02263
uniprot id: Q92069
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AK119Ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties, leading to the recruitment of repair proteins to sites of DNA damage. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:SIGMAR1
gene id: 9031:SIGMAR1
uniprot id: A0A1D5P285
uniprot id: Q5ZL84
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer (By similarity).
messages: Homotrimer.
messages: May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile.
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

9031:CDK6
gene id: 9031:CDK6
uniprot id: Q90771
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:PRICKLE2
gene id: 9031:PRICKLE2
uniprot id: F1N8U0
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

9031:NOVA1
gene id: 9031:NOVA1
uniprot id: R4GG35
uniprot id: R4GH08
names: Subcellular Location Annotation
messages: Cytoplasm

9031:SARS1
gene id: 9031:SARS1
uniprot id: Q5ZM75
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9031:CORO2A
gene id: 9031:CORO2A
uniprot id: A0A3Q2U1C6
names: Similarity
messages: Belongs to the WD repeat coronin family.

9031:CENPW
gene id: 9031:CENPW
uniprot id: P0DJH6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Association with CENPA-containing complexes may be indirect and due to the proximity of centromeric nucleosomes containing histone H3 with those containing CENPA.
messages: Belongs to the CENP-W/WIP1 family.
messages: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
messages: Heterodimer with CENPT; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex, which is a subcomplex of the large constitutive centromere-associated network (CCAN, also known as the interphase centromere complex or ICEN) (PubMed:19070575, PubMed:21464230, PubMed:22304917). Interacts with NPM1 (By similarity).
messages: Nucleus
messages: centromere
messages: kinetochore

9031:DOCK4
gene id: 9031:DOCK4
uniprot id: A0A3Q2TW91
uniprot id: A0A3Q2U1P6
uniprot id: A0A3Q2U582
names: Similarity
messages: Belongs to the DOCK family.

9031:HOXC10
gene id: 9031:HOXC10
uniprot id: A0A1D5PP81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9031:SHISA5
gene id: 9031:SHISA5
uniprot id: Q5ZIS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shisa family.
messages: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: The proline-rich region is required for endoplasmic reticulum localization.

9031:LOC107050476
gene id: 9031:LOC107050476
uniprot id: A0A3Q2U518
names: Function
messages: Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.
messages: Capsid protein p27: Self-associates to form the irregular polyhedron core composed of hexamers and pentamers, that encapsulates the genomic RNA-nucleocapsid complex. Assembles as a tube in vitro.
messages: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.

9031:STRBP
gene id: 9031:STRBP
uniprot id: Q5ZIL4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in normal spermatogenesis and sperm function. Binds to double-stranded DNA and RNA (By similarity).

9031:OPN3
gene id: 9031:OPN3
uniprot id: E1C1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9031:PRKAA2
gene id: 9031:PRKAA2
uniprot id: Q2LAI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm

9031:SOX14
gene id: 9031:SOX14
uniprot id: Q9W7R6
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a negative regulator of transcription.
messages: Highly expressed in developing brain and spinal cord.
messages: Nucleus

9031:SBK1
gene id: 9031:SBK1
uniprot id: H9L0G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

9031:OPTN
gene id: 9031:OPTN
uniprot id: Q90Z16
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to linear ubiquitin chains. Interacts with LC3 family members (By similarity).
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Expressed in erythrocytes, skeletal muscle, heart, spleen and brain. Weakly expressed in lung and liver (at protein level).
messages: Golgi apparatus
messages: Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.
messages: Recycling endosome
messages: The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins.
messages: Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

9031:SLC35A5
gene id: 9031:SLC35A5
uniprot id: F1NTH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9031:RDM1
gene id: 9031:RDM1
uniprot id: F1NKR6
uniprot id: Q8JFQ4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Confers resistance to the antitumor agent cisplatin. Binds preferentially to sites of DNA modified by cisplatin in vitro. Binds to double-stranded DNA in a cooperative manner resulting in the formation of filament-like structures. Binds to single-stranded DNA with no cooperativity. Binds to RNA.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: nucleolus

9031:CNOT10
gene id: 9031:CNOT10
uniprot id: Q5ZIW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).
messages: Component of the CCR4-NOT complex. CNOT10 and CNOT11 form a subcomplex docked to the CNOT1 scaffold (By similarity).
messages: Cytoplasm
messages: Nucleus

9031:VPS37A
gene id: 9031:VPS37A
uniprot id: F1NVI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9031:CLDN5
gene id: 9031:CLDN5
uniprot id: Q98SR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:EVA1B
gene id: 9031:EVA1B
uniprot id: H9L2U6
names: Similarity
messages: Belongs to the EVA1 family.

9031:CYP26A1
gene id: 9031:CYP26A1
uniprot id: Q9PUB4
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription (PubMed:10588879). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 (PubMed:10588879). Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (By similarity).
messages: Belongs to the cytochrome P450 family.
messages: By retinoic acid.
messages: Endoplasmic reticulum membrane
messages: Expressed at stage 4 in the ectoderm, stage 5-7 in the nascent notochord and at stage 7 its expression decreases in the anterior part of the embryo. From stage 7-10 its expression is restricted to the dorsal folds of the neural tube and to rhombomere 2. At stage 10, it is expressed in the lateral plate endoderm and in the tail bud and by stage 11/12 it disappears in the neural tube, followed by a confined expression at stage 12 to dorsal neural tube and at stage 15 an increasing expression in the ectoderm.
messages: Microsome membrane

9031:ETS2
gene id: 9031:ETS2
uniprot id: P10157
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Probable transcription factor.

9031:TMC7
gene id: 9031:TMC7
uniprot id: A0A1D5P7T7
uniprot id: A0A3Q2UAH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9031:ST8SIA2
gene id: 9031:ST8SIA2
uniprot id: A0A1D5PHM7
uniprot id: Q6ZXD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:PROM1
gene id: 9031:PROM1
uniprot id: E1C9E2
uniprot id: F1CLE7
uniprot id: F1CLE8
uniprot id: F1CLE9
uniprot id: F1CLF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9031:CLDN9
gene id: 9031:CLDN9
uniprot id: A0A1D5PQ41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:G6PC3
gene id: 9031:G6PC3
uniprot id: A0A3Q2U8J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9031:ELMO3
gene id: 9031:ELMO3
uniprot id: A0A1D5PP23
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9031:PDPK1
gene id: 9031:PDPK1
uniprot id: Q5F3U4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

9031:MAPK10
gene id: 9031:MAPK10
uniprot id: A0A1D5PXC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9031:SLC10A2
gene id: 9031:SLC10A2
uniprot id: A0A3S5ZP78
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

9031:NPY5R
gene id: 9031:NPY5R
uniprot id: F1NWY5
uniprot id: Q8QFM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

9031:GRIA2
gene id: 9031:GRIA2
uniprot id: Q90856
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:NUCB2
gene id: 9031:NUCB2
uniprot id: Q5ZHR1
names: Similarity
messages: Belongs to the nucleobindin family.

9031:TGFBR1
gene id: 9031:TGFBR1
uniprot id: Q06900
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9031:RPS3
gene id: 9031:RPS3
uniprot id: Q5ZJC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: nucleolus
messages: spindle

9031:CA6
gene id: 9031:CA6
uniprot id: F1NZ64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversible hydration of carbon dioxide. Its role in saliva is unknown.
messages: Secreted

9031:ADH6
gene id: 9031:ADH6
uniprot id: O42483
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9031:NADK2
gene id: 9031:NADK2
uniprot id: F1NJV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

9031:PRDX6
gene id: 9031:PRDX6
uniprot id: Q5ZJF4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration (By similarity).
messages: Irreversibly inactivated by overoxidation of Cys-46 to sulfinic acid (Cys-SO(2)H) and sulfonic acid (Cys-SO(3)H) forms upon oxidative stress.
messages: Lysosome
messages: Phosphorylation at Thr-176 by MAP kinases increases the phospholipase activity of the enzyme (By similarity). The phosphorylated form exhibits a greater lysophosphatidylcholine acyltransferase activity compared to the non-phosphorylated form (By similarity).
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) is reactivated by glutathionylation mediated by glutathione S-transferase Pi, followed by spontaneous reduction of the enzyme with glutathione.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity).

9031:SEC61A2
gene id: 9031:SEC61A2
uniprot id: A0A1D5NXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:TJP1
gene id: 9031:TJP1
uniprot id: A0A1D5NWX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9031:CEP41
gene id: 9031:CEP41
uniprot id: E1C065
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP41 family.
messages: Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of tubulin polyglutamylases between the basal body and the cilium (By similarity).
messages: centrosome
messages: cilium
messages: cilium basal body

9031:FGD4
gene id: 9031:FGD4
uniprot id: A0A3Q2TYC8
uniprot id: A0A3Q2TZP0
uniprot id: E1C246
names: Subcellular Location Annotation
messages: cytoskeleton

9031:PHOX2B
gene id: 9031:PHOX2B
uniprot id: F1NMR6
names: Subcellular Location Annotation
messages: Nucleus

9031:SLC26A6
gene id: 9031:SLC26A6
uniprot id: R4GKK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

9031:CYP2D6
gene id: 9031:CYP2D6
uniprot id: F1NJG4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:ABHD12
gene id: 9031:ABHD12
uniprot id: Q5ZIN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).

9031:ST8SIA1
gene id: 9031:ST8SIA1
uniprot id: P79783
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:ZC3H12D
gene id: 9031:ZC3H12D
uniprot id: A0A1D5P1H9
names: Similarity
messages: Belongs to the ZC3H12 family.

9031:MAPKAPK2
gene id: 9031:MAPKAPK2
uniprot id: F1NCY7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:PTGS2
gene id: 9031:PTGS2
uniprot id: A0A1D5P416
uniprot id: P27607
names: Caution
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: By cytokines and mitogens.
messages: Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PTGS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PTGS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
messages: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane
messages: PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen. Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.
messages: The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.

9031:RUNX1
gene id: 9031:RUNX1
uniprot id: A0A3Q2TTQ9
uniprot id: Q90813
names: Subcellular Location Annotation
messages: Nucleus

9031:E2F5
gene id: 9031:E2F5
uniprot id: Q5ZI31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9031:HMGN5
gene id: 9031:HMGN5
uniprot id: A3RKL2
uniprot id: P12902
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
messages: Nucleus
messages: There are two HMG-14 proteins in chicken: HMG-14A the major component, and HMG-14B the minor component.

9031:PHKG1
gene id: 9031:PHKG1
uniprot id: Q5ZJ45
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9031:AGPS
gene id: 9031:AGPS
uniprot id: F1P5J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
messages: Homodimer.
messages: Peroxisome

9031:XPO1
gene id: 9031:XPO1
uniprot id: A0A1D5P8H7
uniprot id: Q5ZIV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9031:CCLL4
gene id: 9031:CCLL4
uniprot id: Q5IEZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:LIN52
gene id: 9031:LIN52
uniprot id: Q5ZJQ3
names: Similarity
names: Subunit
messages: Belongs to the lin-52 family.
messages: Component of the DREAM complex.

9031:SERINC5
gene id: 9031:SERINC5
uniprot id: A0A3Q2UCB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

9031:INHBA
gene id: 9031:INHBA
uniprot id: A0A1D5NV71
uniprot id: P27092
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Ciliary ganglion neurons. Levels are higher in the choroid than the iris.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may play a role in regulating neurotransmitter phenotype.
messages: Levels increase in the iris from embryonic day 9 (9 dpc) to 16 dpc and in the choroid, levels are high from 9 dpc to 14 dpc but drop at 16 dpc.
messages: Secreted

9031:CAMK1G
gene id: 9031:CAMK1G
uniprot id: E1BQ82
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:RFC4
gene id: 9031:RFC4
uniprot id: Q5ZHL1
names: Similarity
messages: Belongs to the activator 1 small subunits family.

9031:CHMP2A
gene id: 9031:CHMP2A
uniprot id: A0A1D5PCX2
uniprot id: Q5ZHN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).

9031:ADCY9
gene id: 9031:ADCY9
uniprot id: A0A1L1RTJ6
uniprot id: F1NP57
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9031:AKT3
gene id: 9031:AKT3
uniprot id: A0A1D5NTY9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

9031:PNRC1
gene id: 9031:PNRC1
uniprot id: Q5ZII5
names: Subcellular Location Annotation
messages: Nucleus

9031:DHRS7
gene id: 9031:DHRS7
uniprot id: E1BV75
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:SELENBP1
gene id: 9031:SELENBP1
uniprot id: H9KYX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Membrane
messages: Nucleus
messages: cytosol

9031:ABCG1
gene id: 9031:ABCG1
uniprot id: E1BYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9031:KARS
gene id: 9031:KARS
uniprot id: Q5ZKP8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9031:ESR1
gene id: 9031:ESR1
uniprot id: P06212
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-beta.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).
messages: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

9031:IL12RB2
gene id: 9031:IL12RB2
uniprot id: Q5GR16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9031:PRDM12
gene id: 9031:PRDM12
uniprot id: E1C6K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

9031:GATA5
gene id: 9031:GATA5
uniprot id: F1NZV5
names: Subcellular Location Annotation
messages: Nucleus

9031:CYLY
gene id: 9031:CYLY
uniprot id: E1BYH8
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9031:RPA3
gene id: 9031:RPA3
uniprot id: E1C4C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

9031:VWC2L
gene id: 9031:VWC2L
uniprot id: E1BSM6
names: Subcellular Location Annotation
messages: Synapse

9031:MTM1
gene id: 9031:MTM1
uniprot id: E1BRL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

9031:RDH10
gene id: 9031:RDH10
uniprot id: A0A1D5PLZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9031:EIF4ENIF1
gene id: 9031:EIF4ENIF1
uniprot id: E1BTK8
names: Subcellular Location Annotation
messages: Cytoplasm

9031:GPR4
gene id: 9031:GPR4
uniprot id: E1C4B9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:STAT1
gene id: 9031:STAT1
uniprot id: Q5ZJK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9031:EPCAM
gene id: 9031:EPCAM
uniprot id: Q5F381
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lateral cell membrane

9031:ADIPOR2
gene id: 9031:ADIPOR2
uniprot id: Q5ZMH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9031:MPG
gene id: 9031:MPG
uniprot id: R4GJJ1
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

9031:GLB1
gene id: 9031:GLB1
uniprot id: Q5ZLM4
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9031:LOC428499
gene id: 9031:LOC428499
uniprot id: A0A1D5NWC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9031:FOLR1
gene id: 9031:FOLR1
uniprot id: F1N9X0
uniprot id: Q9PW81
names: Similarity
messages: Belongs to the folate receptor family.

9031:HHATL
gene id: 9031:HHATL
uniprot id: E1C1S6
names: Subcellular Location Annotation
messages: Membrane

9031:EPS8
gene id: 9031:EPS8
uniprot id: A0A3Q2U0U0
uniprot id: E1BVA1
names: Similarity
messages: Belongs to the EPS8 family.

9031:HSPA9
gene id: 9031:HSPA9
uniprot id: Q5ZM98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging.
messages: Interacts strongly with the intermediate form of FXN and weakly with its mature form. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Mitochondrion

9031:MTF2
gene id: 9031:MTF2
uniprot id: Q6X7S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9031:DNTT
gene id: 9031:DNTT
uniprot id: P36195
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Can also utilize other divalent cations, such as Mn(2+) and Co(2+) (in vitro).
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

9031:NPPA
gene id: 9031:NPPA
uniprot id: P18908
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Cleaved by CORIN upon secretion to produce the functional hormone.
messages: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).
messages: Secreted

9031:NUBP2
gene id: 9031:NUBP2
uniprot id: Q5ZKV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.

9031:DNAJB14
gene id: 9031:DNAJB14
uniprot id: F1P414
names: Subcellular Location Annotation
messages: Membrane

9031:PPP2R3C
gene id: 9031:PPP2R3C
uniprot id: F1N899
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:CHST10
gene id: 9031:CHST10
uniprot id: Q5ZIE4
uniprot id: R4GFR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sulfotransferase 2 family.
messages: Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult (By similarity).
messages: Golgi apparatus membrane
messages: Membrane
messages: Predominantly expressed in hypertrophic, prehypertrophic and proliferative chondrocytes at E12 but is down-regulated in epiphyseal chondrocytes.

9031:TAAR2
gene id: 9031:TAAR2
uniprot id: E1C0A1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:SLC16A5
gene id: 9031:SLC16A5
uniprot id: F1NSI6
names: Subcellular Location Annotation
messages: Membrane

9031:NUP62
gene id: 9031:NUP62
uniprot id: F1NFA8
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9031:RPL9
gene id: 9031:RPL9
uniprot id: A0A1D5NVI1
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

9031:MARCH4
gene id: 9031:MARCH4
uniprot id: A0A1D5PG09
names: Subcellular Location Annotation
messages: Membrane

9031:C9ORF58
gene id: 9031:C9ORF58
uniprot id: X2J6L4
names: Subcellular Location Annotation
messages: ruffle membrane

9031:AIDA
gene id: 9031:AIDA
uniprot id: E1BRY9
names: Similarity
messages: Belongs to the AIDA family.

9031:CXorf36
gene id: 9031:CXorf36
uniprot id: F1NKD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9031:ATRNL1
gene id: 9031:ATRNL1
uniprot id: A0A3Q2U610
uniprot id: A0A3Q2UFR3
uniprot id: E1BYK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:YWHAH
gene id: 9031:YWHAH
uniprot id: Q5ZKJ2
names: Similarity
messages: Belongs to the 14-3-3 family.

9031:GLDC
gene id: 9031:GLDC
uniprot id: P15505
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GcvP family.
messages: Homodimer. Interacts with GCSH. The glycine cleavage system is composed of four proteins: P (GLDC), T (GCST), L (DLD) and H (GCSH).
messages: Liver (at protein level).
messages: Mitochondrion
messages: Stimulated by lipoic acid. Inhibited in presence of methylamine.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).

9031:UTP11
gene id: 9031:UTP11
uniprot id: E1BU24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

9031:MAEA
gene id: 9031:MAEA
uniprot id: Q5F398
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity).
messages: Cytoplasm
messages: Identified in the CTLH complex that contains at least MAEA, RMND5A, GID8, WDR26, and RANBP9 and/or RANBP10 as the catalytic core. Interacts with F-actin.
messages: Nucleus matrix
messages: The expected RING-type zinc finger domain is highly divergent and most of the expected Cys residues are not conserved. Still, the protein is required for CTLH complex E3 ubiquitin-protein transferase activity. In addition, the conserved Cys-314 in this highly divergent region is required for ubiquitination by the yeast GID complex, suggesting a direct role in catalyzing ubiquitination.
messages: cytoskeleton
messages: nucleoplasm

9031:RSPO4
gene id: 9031:RSPO4
uniprot id: A0A3Q2UA97
uniprot id: E1BVQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9031:TRUB1
gene id: 9031:TRUB1
uniprot id: A0A1D5PW26
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9031:IFT57
gene id: 9031:IFT57
uniprot id: E1C8D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9031:RPL7A
gene id: 9031:RPL7A
uniprot id: P32429
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9031:EXOSC3
gene id: 9031:EXOSC3
uniprot id: F1NWK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm

9031:MOSPD1
gene id: 9031:MOSPD1
uniprot id: F1NE32
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

9031:ESF1
gene id: 9031:ESF1
uniprot id: A0A1D5P3E5
uniprot id: Q5ZK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9031:QSOX1
gene id: 9031:QSOX1
uniprot id: Q8JGM4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.
messages: Golgi apparatus membrane
messages: N-glycosylated. O-glycosylated on Thr and Ser residues.
messages: Secreted

9031:SUPT20H
gene id: 9031:SUPT20H
uniprot id: F1N922
uniprot id: Q5ZM71
names: Function
names: Similarity
messages: Belongs to the SPT20 family.
messages: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation.

9031:CACUL1
gene id: 9031:CACUL1
uniprot id: Q5ZMM9
names: Similarity
messages: Belongs to the cullin family.

9031:COPA
gene id: 9031:COPA
uniprot id: Q5F354
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9031:VPS53
gene id: 9031:VPS53
uniprot id: Q5ZLD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Belongs to the VPS53 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome membrane
messages: Recycling endosome
messages: trans-Golgi network membrane

9031:ZNF488
gene id: 9031:ZNF488
uniprot id: F1P059
names: Subcellular Location Annotation
messages: Nucleus

9031:TSNAX
gene id: 9031:TSNAX
uniprot id: A0A1D5PPF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9031:RPL38
gene id: 9031:RPL38
uniprot id: E1BU66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9031:CACNA1B
gene id: 9031:CACNA1B
uniprot id: Q9PUM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

9031:CCNG1
gene id: 9031:CCNG1
uniprot id: E1BUH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin G subfamily.
messages: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
messages: Nucleus

9031:RAB9A
gene id: 9031:RAB9A
uniprot id: Q5ZMI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: phagosome membrane

9031:MAST3
gene id: 9031:MAST3
uniprot id: E1C067
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

9031:YIPF4
gene id: 9031:YIPF4
uniprot id: Q5ZJD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Involved in the maintenance of the Golgi structure.
messages: cis-Golgi network membrane

9031:CLNS1A
gene id: 9031:CLNS1A
uniprot id: F1NYD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

9031:SMC6
gene id: 9031:SMC6
uniprot id: E1BWW3
names: Subcellular Location Annotation
messages: Chromosome

9031:DVL2
gene id: 9031:DVL2
uniprot id: A0A1D5NY00
names: Similarity
messages: Belongs to the DSH family.

9031:ARSG
gene id: 9031:ARSG
uniprot id: E1BU03
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:TRPV4
gene id: 9031:TRPV4
uniprot id: A0A1D5PXA5
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP binding enhances channel sensitivity to agonists. Ca(2+)-calmodulin prevents the ATP-mediated increased sensitivity to agonists.
messages: Apical cell membrane
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily.
messages: Homotetramer (By similarity). Interacts with Ca(2+)-calmodulin (PubMed:19864432).
messages: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by phorbol esters (PubMed:19864432). Channel activity seems to be regulated by a calmodulin-dependent mechanism (By similarity).
messages: The ANK repeat region mediates interaction with Ca(2+)-calmodulin and ATP binding (PubMed:19864432). The ANK repeat region mediates interaction with phosphatidylinositol-4,5-bisphosphate and related phosphatidylinositides (PubMed:25256292).
messages: adherens junction

9031:GRK2
gene id: 9031:GRK2
uniprot id: Q5ZJB8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9031:KCNE3
gene id: 9031:KCNE3
uniprot id: A0A1L1RUH7
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9031:LIN9
gene id: 9031:LIN9
uniprot id: Q5ZMF8
names: Similarity
messages: Belongs to the lin-9 family.

9031:INTS9
gene id: 9031:INTS9
uniprot id: Q5ZKK2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

9031:GFM1
gene id: 9031:GFM1
uniprot id: F1P0J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

9031:FGF13
gene id: 9031:FGF13
uniprot id: A0A1D5PML4
uniprot id: F1NWP9
uniprot id: Q9IAI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

9031:PDHA2
gene id: 9031:PDHA2
uniprot id: A0A1D5PEH3
uniprot id: Q5F426
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9031:ARR3
gene id: 9031:ARR3
uniprot id: A4L9I7
names: Function
names: Similarity
messages: Belongs to the arrestin family.
messages: May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.

9031:GSTT1
gene id: 9031:GSTT1
uniprot id: P20135
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.

9031:HIBADH
gene id: 9031:HIBADH
uniprot id: Q5ZLI9
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9031:NRDE2
gene id: 9031:NRDE2
uniprot id: E1C4F1
names: Similarity
messages: Belongs to the NRDE2 family.

9031:CREG2
gene id: 9031:CREG2
uniprot id: A0A3Q2U8T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9031:KCNMB4
gene id: 9031:KCNMB4
uniprot id: E1C6G7
names: Subcellular Location Annotation
messages: Membrane

9031:C14orf159
gene id: 9031:C14orf159
uniprot id: F1NS20
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

9031:ELMO2
gene id: 9031:ELMO2
uniprot id: A0A3Q2UB91
uniprot id: E1C122
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9031:MEIS1
gene id: 9031:MEIS1
uniprot id: A0A1D5NXZ6
uniprot id: A0A3Q2U0L7
uniprot id: B6Z9R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9031:TMEM106C
gene id: 9031:TMEM106C
uniprot id: A0A1D5NWN7
names: Similarity
messages: Belongs to the TMEM106 family.

9031:THUMPD3
gene id: 9031:THUMPD3
uniprot id: A0A1L1RRY6
names: Similarity
messages: Belongs to the methyltransferase superfamily.

9031:ACADSB
gene id: 9031:ACADSB
uniprot id: Q5ZK70
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9031:NME8
gene id: 9031:NME8
uniprot id: A0A1D5PUV4
names: Similarity
messages: Belongs to the NDK family.

9031:SGMS1
gene id: 9031:SGMS1
uniprot id: F1NRU9
uniprot id: Q7T3T4
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide (By similarity).
messages: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.

9031:SEZ6L
gene id: 9031:SEZ6L
uniprot id: A0A1D5PLR0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SLC25A33
gene id: 9031:SLC25A33
uniprot id: E1C5T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:RBM6
gene id: 9031:RBM6
uniprot id: A0A1D5PAD2
uniprot id: Q5F3M4
names: Subcellular Location Annotation
messages: Nucleus

9031:RHCG
gene id: 9031:RHCG
uniprot id: Q6XL41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Functions as an ammonia transporter.
messages: Homotrimer.

9031:HS3ST3A1
gene id: 9031:HS3ST3A1
uniprot id: F1NL56
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:PDCD10
gene id: 9031:PDCD10
uniprot id: Q5ZIV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.

9031:SH3BGRL
gene id: 9031:SH3BGRL
uniprot id: Q5F3C9
names: Similarity
messages: Belongs to the SH3BGR family.

9031:TRABD2A
gene id: 9031:TRABD2A
uniprot id: R4GFJ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9031:CD2
gene id: 9031:CD2
uniprot id: A0A3Q2U1P9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TNFRSF1A
gene id: 9031:TNFRSF1A
uniprot id: Q5ZJG1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:KCTD20
gene id: 9031:KCTD20
uniprot id: A0A1D5PY88
uniprot id: E1C0U7
names: Subcellular Location Annotation
messages: Cytoplasm

9031:BNIP1
gene id: 9031:BNIP1
uniprot id: F1NC47
names: Subcellular Location Annotation
messages: Membrane

9031:CHRNG
gene id: 9031:CHRNG
uniprot id: F1NJ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:JUN
gene id: 9031:JUN
uniprot id: P18870
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Jun subfamily.
messages: Interacts with FOS to form a dimer. Interacts with Gallid herpesvirus 2 MEQ protein.
messages: Nucleus
messages: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter.

9031:TA3
gene id: 9031:TA3
uniprot id: Q1G7G9
names: Disease Annotation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TALPID3 family.
messages: Defects in Talpid3 are the cause of the spontaneous mutant with pleiotropic phenotype including polydactylous limbs with many unpatterned digits, vascular defects, hypoteleorism, abnormal dorsoventral patterning of the neural tube, loss of endochondral bone formation and embryonic lethality.
messages: Failure of formation of primary and motile cilia in ependymal cells of the prosencephalic choroid plexus. Centrosomes are rarely found near the cell surface but are often mislocalized deep within the cell and do not show coordinate orientation within group.
messages: Required for ciliogenesis and sonic hedgehog/SHH signaling (PubMed:16702409, PubMed:19144723, PubMed:26386247). Independently, involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (PubMed:26386247).
messages: Ubiquitously expressed.
messages: centrosome

9031:SLC2A2
gene id: 9031:SLC2A2
uniprot id: Q90592
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: D-glucose and maltose competitively inhibit fructose transport. D-glucose, D-fructose and maltose inhibit deoxyglucose transport.
messages: Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells.

9031:TYW3
gene id: 9031:TYW3
uniprot id: A0A1D5PIG9
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9031:MDK
gene id: 9031:MDK
uniprot id: A9DAB9
uniprot id: P24052
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pleiotrophin family.
messages: By retinoic acid.
messages: Cell surface
messages: Essentially expressed during embryogenesis.
messages: Has mitogenic activity, and neurite extension activity for PC12 cells.
messages: basement membrane

9031:ADRM1
gene id: 9031:ADRM1
uniprot id: Q98SH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ADRM1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor.
messages: Cytoplasm
messages: Nucleus

9031:TMCC3
gene id: 9031:TMCC3
uniprot id: A0A1D5NZV0
uniprot id: A0A3Q2U1S3
uniprot id: F1NWA6
names: Similarity
messages: Belongs to the TEX28 family.

9031:SNTN
gene id: 9031:SNTN
uniprot id: B7FF67
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: 'Sentan' means 'tip' in Japanese.
messages: Belongs to the S-100 family.
messages: May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.
messages: cilium

9031:FAM214A
gene id: 9031:FAM214A
uniprot id: Q5ZI58
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus
messages: The protein contains 2 transactivation domains (TAD). Each of these domains may be required for transcriptional activation of a subset of target genes.
messages: Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues.

9031:ISY1
gene id: 9031:ISY1
uniprot id: F1P220
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9031:PSMC2
gene id: 9031:PSMC2
uniprot id: Q5ZMB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9031:PSAT1
gene id: 9031:PSAT1
uniprot id: F1NTK1
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

9031:UGT8L
gene id: 9031:UGT8L
uniprot id: F1NQS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9031:VPS54
gene id: 9031:VPS54
uniprot id: E1BRC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

9031:SAMD4A
gene id: 9031:SAMD4A
uniprot id: A0A1D5PW57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

9031:BRMS1L
gene id: 9031:BRMS1L
uniprot id: Q5ZLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRMS1 family.
messages: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity.
messages: Nucleus

9031:BTG2
gene id: 9031:BTG2
uniprot id: A0A3Q3AWP4
names: Similarity
messages: Belongs to the BTG family.

9031:ADCY2
gene id: 9031:ADCY2
uniprot id: A0A3Q2UEX1
uniprot id: E1BX91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9031:DLG3
gene id: 9031:DLG3
uniprot id: A0A3Q2U4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9031:NRG4
gene id: 9031:NRG4
uniprot id: Q5ZJR0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SLC22A4
gene id: 9031:SLC22A4
uniprot id: C0MP42
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9031:YIPF1
gene id: 9031:YIPF1
uniprot id: E1C1H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9031:REEP2
gene id: 9031:REEP2
uniprot id: E1C4N6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:WASHC1
gene id: 9031:WASHC1
uniprot id: F1NMK3
uniprot id: Q5ZKA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
messages: Belongs to the WASH1 family.
messages: Component of the WASH complex.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane
messages: The VCA (verprolin, cofilin, acidic) domain promotes actin polymerization by the Arp2/3 complex in vitro.

9031:SNX13
gene id: 9031:SNX13
uniprot id: E1BZM0
names: Similarity
messages: Belongs to the sorting nexin family.

9031:CELF2
gene id: 9031:CELF2
uniprot id: Q7T2T1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Expressed in heart at embryonic day 12 and 14 (at protein level). Expressed in heart at embryonic day 8.
messages: Expressed in heart.
messages: Nucleus
messages: RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation repression and stability. Mediates exon inclusion in TNNT2 pre-mRNA.

9031:RBM24
gene id: 9031:RBM24
uniprot id: Q5ZMA3
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed in differentiated myotomal muscle progenitors in embryos at 3 days of development (at protein level). Expressed in somites in embryos at 3 and 3.5 days of development. Expressed in the mesodermal core of the first and second branchial arches at 3 days of development. Expressed in forelimbs and hindlimbs at 3.5 days of development. Expressed in non-muscle territories including lens and otic vesicle at 3 days of development.
messages: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating MYOG levels. Binds to a huge amount of mRNAs (By similarity). Involved in embryonic heart development and myogenic differentiation of somitic muscle progenitors (PubMed:25217815).
messages: Nucleus
messages: The RRM domain is necessary for mRNA stability and mRNA translation regulation.

9031:UTS2R
gene id: 9031:UTS2R
uniprot id: E1BYR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

9031:PCDHA4
gene id: 9031:PCDHA4
uniprot id: Q6R0I7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:RAD1
gene id: 9031:RAD1
uniprot id: A0A1D5PSK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9031:PTER
gene id: 9031:PTER
uniprot id: E1BWG7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ELP3
gene id: 9031:ELP3
uniprot id: Q5ZHS1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
messages: Component of the elongator complex.
messages: Cytoplasm
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

9031:TBX3
gene id: 9031:TBX3
uniprot id: A0A1D5NXF3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:SLC13A3
gene id: 9031:SLC13A3
uniprot id: A0A3Q2TZV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9031:PTDSS1
gene id: 9031:PTDSS1
uniprot id: Q5ZM65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
messages: Endoplasmic reticulum membrane

9031:RAD50
gene id: 9031:RAD50
uniprot id: F1NEG1
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

9031:RAB5C
gene id: 9031:RAB5C
uniprot id: Q98932
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Detected in brain, ovary, rectum, small intestine, large intestine, liver, spleen, follicle and kidney (at protein level).
messages: Early endosome membrane
messages: Protein transport. Probably involved in vesicular traffic.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.

9031:ANXA5
gene id: 9031:ANXA5
uniprot id: P17153
names: Domain
names: Function
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Collagen-binding protein.

9031:TMEM138
gene id: 9031:TMEM138
uniprot id: A0A1D5PE71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

9031:GNG5
gene id: 9031:GNG5
uniprot id: R4GKD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9031:COPS7A
gene id: 9031:COPS7A
uniprot id: Q5ZJA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

9031:RNF10
gene id: 9031:RNF10
uniprot id: A0A1D5PZ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

9031:ALDH1A1
gene id: 9031:ALDH1A1
uniprot id: F1NJC7
uniprot id: P27463
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (By similarity). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
messages: Homotetramer.
messages: axon
messages: cytosol

9031:SV2B
gene id: 9031:SV2B
uniprot id: A0A1D5PW37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9031:DNMT3B
gene id: 9031:DNMT3B
uniprot id: A0A1D5PJJ1
uniprot id: A0A3Q3A961
names: Subcellular Location Annotation
messages: Nucleus

9031:NDUFV1
gene id: 9031:NDUFV1
uniprot id: Q5ZHS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

9031:LMF2
gene id: 9031:LMF2
uniprot id: A0A1D5P8M7
uniprot id: Q5ZKZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).
messages: Membrane

9031:MFAP5
gene id: 9031:MFAP5
uniprot id: A0A3Q2UBC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

9031:PRXL2A
gene id: 9031:PRXL2A
uniprot id: A0A0F6YFH3
uniprot id: Q5ZI34
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm
messages: Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass (By similarity).
messages: The active site Cys-88 corresponds to one of the redox-active cysteines of peroxiredoxins.

9031:TOR3A
gene id: 9031:TOR3A
uniprot id: E1BTE7
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9031:LOC422929
gene id: 9031:LOC422929
uniprot id: E1BX72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:UPF2
gene id: 9031:UPF2
uniprot id: A0A1D5PHS9
names: Subcellular Location Annotation
messages: Cytoplasm

9031:EEF1A1
gene id: 9031:EEF1A1
uniprot id: Q90835
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9031:SGMS2
gene id: 9031:SGMS2
uniprot id: F1NLG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9031:DDX17
gene id: 9031:DDX17
uniprot id: A0A1D5PD32
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:PIK3C2A
gene id: 9031:PIK3C2A
uniprot id: E1C1G0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:MNAT1
gene id: 9031:MNAT1
uniprot id: E1BVP0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

9031:FAM129A
gene id: 9031:FAM129A
uniprot id: F1NG00
uniprot id: Q5F374
names: Similarity
messages: Belongs to the Niban family.

9031:ATP10B
gene id: 9031:ATP10B
uniprot id: E1BX05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:POU3F3
gene id: 9031:POU3F3
uniprot id: A0A1D5PY72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9031:BCL2L13
gene id: 9031:BCL2L13
uniprot id: E1BXS1
names: Similarity
messages: Belongs to the Bcl-2 family.

9031:MASP2
gene id: 9031:MASP2
uniprot id: Q6Q1Q9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:EDEM3
gene id: 9031:EDEM3
uniprot id: A0A1D5PEI6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9031:GPR132
gene id: 9031:GPR132
uniprot id: R4GHJ0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:STX18
gene id: 9031:STX18
uniprot id: E1C1M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

9031:LOC415662
gene id: 9031:LOC415662
uniprot id: A0A1D5PSE2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:AP3M2
gene id: 9031:AP3M2
uniprot id: A0A1D5NUM5
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

9031:CAPN5
gene id: 9031:CAPN5
uniprot id: A0A1D5PFI2
names: Similarity
messages: Belongs to the peptidase C2 family.

9031:CLOCK
gene id: 9031:CLOCK
uniprot id: Q8QGQ6
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Forms a heterodimer with BMAL1 (PubMed:10931848). The CLOCK-BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and for phosphorylation of both CLOCK and BMAL1 (By similarity). Interaction with PER and CRY proteins requires translocation to the nucleus (By similarity). Interaction of the CLOCK-BMAL1 heterodimer with PER or CRY inhibits transcription activation (By similarity). Interacts with BMAL2 (PubMed:11554928).
messages: Cytoplasm
messages: Expressed in a circadian rhythm manner in the retina. Levels increase over daylight hours, reaching maximum levels between ZT12 and ZT18. Expression levels continue to oscillate during constant darkness, with levels increasing during subjective day to reach maximum levels between day/night transition. In the pineal gland, shows no robust circadian rhythm with only a slight increase in expression between ZT10-18.
messages: Expressed in the retinal photoreceptor cells (at protein level). Isoform 1 is expressed in both the retina and pineal gland. Isoform 2 is expressed mainly in the pineal gland.
messages: Nucleus
messages: O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-BMAL1 heterodimer thereby increasing CLOCK-BMAL1-mediated transcriptional activation of PER1/2/3 and CRY1/2.
messages: Phosphorylation is dependent on the CLOCK-BMAL1 heterodimer formation. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the heterodimer by promoting its degradation.
messages: Sumoylation enhances its transcriptional activity and interaction with ESR1, resulting in up-regulation of ESR1 activity. Estrogen stimulates sumoylation. Desumoylation by SENP1 negatively regulates its transcriptional activity.
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …
messages: Ubiquitinated, leading to its proteasomal degradation.
messages: Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.
messages: cytosol

9031:GALNT12
gene id: 9031:GALNT12
uniprot id: F1NMD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:CCKAR
gene id: 9031:CCKAR
uniprot id: A0ZPS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9031:SCARB1
gene id: 9031:SCARB1
uniprot id: A0A1D5PMI6
uniprot id: A0A3Q2TTF7
uniprot id: F1NAN9
names: Similarity
messages: Belongs to the CD36 family.

9031:ZCCHC6
gene id: 9031:ZCCHC6
uniprot id: A0A3Q2U7I6
uniprot id: F1NJM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

9031:UBAC1
gene id: 9031:UBAC1
uniprot id: Q5ZJI9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the KPC complex.
messages: Cytoplasm
messages: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase.

9031:FXR1
gene id: 9031:FXR1
uniprot id: Q5F3S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasm

9031:MYF5
gene id: 9031:MYF5
uniprot id: Q08856
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

9031:TRMT11
gene id: 9031:TRMT11
uniprot id: Q6YJI5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

9031:PPP1R1C
gene id: 9031:PPP1R1C
uniprot id: E1BYA0
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

9031:CRHR1
gene id: 9031:CRHR1
uniprot id: Q90812
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
messages: Interacts (via N-terminal extracellular domain) with CRF and UCN.
messages: The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).

9031:ACOX1
gene id: 9031:ACOX1
uniprot id: Q5ZM10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9031:PLIN3L
gene id: 9031:PLIN3L
uniprot id: E1BR35
names: Similarity
messages: Belongs to the perilipin family.

9031:CEP295
gene id: 9031:CEP295
uniprot id: A0A1D5P981
names: Subcellular Location Annotation
messages: centrosome

9031:NOTCH2
gene id: 9031:NOTCH2
uniprot id: F1P236
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9031:DRD2
gene id: 9031:DRD2
uniprot id: A0A1D5PDB7
uniprot id: A9YZQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:COPE
gene id: 9031:COPE
uniprot id: Q5ZIK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

9031:FBN2
gene id: 9031:FBN2
uniprot id: A0A1D5PRD6
uniprot id: E1C3A6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:MYH1F
gene id: 9031:MYH1F
uniprot id: A0A1D5P603
uniprot id: Q9PTY2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:S100A11
gene id: 9031:S100A11
uniprot id: P24479
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the S-100 family.
messages: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
messages: Homodimer; disulfide-linked.
messages: Smooth muscle and non-muscle tissues.

9031:SSR2
gene id: 9031:SSR2
uniprot id: Q5ZLW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9031:TM4SF4
gene id: 9031:TM4SF4
uniprot id: E1C345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9031:COG6
gene id: 9031:COG6
uniprot id: A0A3Q2UCG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9031:LITAF
gene id: 9031:LITAF
uniprot id: F1NNL3
uniprot id: Q8QGW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines.
messages: The LITAF domain is stabilized by a bound zinc ion. The LITAF domain contains an amphipathic helix that mediates interaction with lipid membranes.

9031:LNPK
gene id: 9031:LNPK
uniprot id: A0A1D5PNA3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9031:ATP5J2
gene id: 9031:ATP5J2
uniprot id: A0A1D5P1J7
names: Function
names: Similarity
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

9031:LOC428293
gene id: 9031:LOC428293
uniprot id: A0A1D5PNR7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:CAB39L
gene id: 9031:CAB39L
uniprot id: A0A1L1RL30
uniprot id: F1NV80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9031:TMEM254
gene id: 9031:TMEM254
uniprot id: E1BZD7
names: Subcellular Location Annotation
messages: Membrane

9031:EIF2AK3
gene id: 9031:EIF2AK3
uniprot id: E1BX69
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9031:SMG1
gene id: 9031:SMG1
uniprot id: A0A1D5PE85
uniprot id: E1BW33
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9031:GHR
gene id: 9031:GHR
uniprot id: F1N9U3
uniprot id: Q02092
names: Disease Annotation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Broad specificity.
messages: Cell membrane
messages: Defects in GHR are a cause of sex-linked dwarf chicken. A restriction fragment length polymorphism, and an aberrantly-sized transcript in liver leads to a GHR with undetectable GH-binding activity causing growth deficiency and other endocrine abnormalities.
messages: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.
messages: On GH binding, proteolytically cleaved, in vitro, to produce GHBP.
messages: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.
messages: On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).
messages: Proteolytically cleaved, in vitro, to release the growth hormone-binding protein (GHBP).
messages: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
messages: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

9031:IFNKL1
gene id: 9031:IFNKL1
uniprot id: A0A3S5ZPG4
uniprot id: H8XX39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:DDX49
gene id: 9031:DDX49
uniprot id: A0A1D5PVV4
uniprot id: Q5ZLA8
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:TMEM234
gene id: 9031:TMEM234
uniprot id: A0A1D5PTZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

9031:FXYD6
gene id: 9031:FXYD6
uniprot id: Q5ZM59
names: Similarity
messages: Belongs to the FXYD family.

9031:GALR1L
gene id: 9031:GALR1L
uniprot id: B2CNR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:CORO1C
gene id: 9031:CORO1C
uniprot id: Q5ZI60
names: Similarity
messages: Belongs to the WD repeat coronin family.

9031:EIF3H
gene id: 9031:EIF3H
uniprot id: Q5ZLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:EDC3
gene id: 9031:EDC3
uniprot id: A0A1D5NZF2
uniprot id: Q5ZLS2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).
messages: P-body
messages: The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with other proteins (By similarity).

9031:RPL11
gene id: 9031:RPL11
uniprot id: A0A1D5P3B1
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

9031:CD40LG
gene id: 9031:CD40LG
uniprot id: B6RCP9
uniprot id: Q9I8D8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer (By similarity). Homotrimer (By similarity). Interacts with CD28 (By similarity). CD40 ligand, soluble form: Exists as either a monomer or a homotrimer (By similarity). Forms a ternary complex between CD40 and integrins for CD40-CD40LG signaling (By similarity).
messages: Homotrimer.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9031:ARNTL2
gene id: 9031:ARNTL2
uniprot id: Q8QGQ7
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with CLOCK to form the BMAL2-CLOCK transactivator. Can form heterodimers or homodimers which interact directly with CLOCK to form the transcription activator.
messages: Expressed in the pineal gland.
messages: Expression in the pineal gland exhibits circadian rhythm. Maximum levels expressed at CT14, and between ZT14 and ZT18.
messages: Nucleus
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …

9031:SERBP1
gene id: 9031:SERBP1
uniprot id: A0A1D5NZM0
uniprot id: Q5F3L2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:EI24
gene id: 9031:EI24
uniprot id: A0A1D5PTF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

9031:BTG4
gene id: 9031:BTG4
uniprot id: E1C802
names: Similarity
messages: Belongs to the BTG family.

9031:PHACTR1
gene id: 9031:PHACTR1
uniprot id: A0A3Q2U074
uniprot id: A0A3Q3ACR1
uniprot id: Q801X6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers.
messages: Binds three actin monomers via the three C-terminal RPEL repeats.
messages: Cytoplasm
messages: Expressed in the gizzard, and in neurons from central and peripheral nervous systems.
messages: Interacts (via RPEL repeats) with ACTA1.
messages: Nucleus
messages: Synapse

9031:CUTAL
gene id: 9031:CUTAL
uniprot id: F1NKZ5
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

9031:GSTK1
gene id: 9031:GSTK1
uniprot id: F1N9G6
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

9031:DOCK9
gene id: 9031:DOCK9
uniprot id: A0A1D5P0V2
uniprot id: A0A3Q2U9X2
uniprot id: A0A3Q3A5Y1
uniprot id: E1BR01
names: Similarity
messages: Belongs to the DOCK family.

9031:MTRF1
gene id: 9031:MTRF1
uniprot id: E1BXF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9031:SEMA4D
gene id: 9031:SEMA4D
uniprot id: A0A3Q3A9P7
uniprot id: F1NCF9
uniprot id: Q90665
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the semaphorin family.
messages: Cell membrane
messages: Cell surface receptor for PLXNB1 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity).
messages: Homodimer (By similarity). Interacts with PLXNB1 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:STXBP5L
gene id: 9031:STXBP5L
uniprot id: A0A1D5P543
uniprot id: A0A1D5P9W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9031:KCNJ11
gene id: 9031:KCNJ11
uniprot id: F1NBC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

9031:CLSTN1
gene id: 9031:CLSTN1
uniprot id: E1BYQ5
uniprot id: Q9DDD3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9031:BMPR2
gene id: 9031:BMPR2
uniprot id: O42124
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9031:PDGFRL
gene id: 9031:PDGFRL
uniprot id: E1C836
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Secreted

9031:LNPEP
gene id: 9031:LNPEP
uniprot id: A0A1D5PL84
uniprot id: F1NNE7
names: Similarity
messages: Belongs to the peptidase M1 family.

9031:PGLYRP2
gene id: 9031:PGLYRP2
uniprot id: A0A1L1RRT4
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9031:NR2F2
gene id: 9031:NR2F2
uniprot id: Q90733
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Binds DNA as a homodimer.
messages: Highly expressed in the developing spinal motor neurons.
messages: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development.
messages: Nucleus

9031:MCTS1
gene id: 9031:MCTS1
uniprot id: Q5ZI42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm
messages: Plays a role as translation enhancer and involved in cell cycle regulation.
messages: The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function.

9031:CHMP7
gene id: 9031:CHMP7
uniprot id: Q5ZJB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (By similarity). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (By similarity). Recruited to the reforming NE during anaphase by LEMD2 (By similarity). Plays a role in the endosomal sorting pathway (By similarity).
messages: Nucleus envelope

9031:ADH4
gene id: 9031:ADH4
uniprot id: Q5ZK81
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

9031:GCNT1
gene id: 9031:GCNT1
uniprot id: F1NU59
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9031:CAPZB
gene id: 9031:CAPZB
uniprot id: P14315
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex (By similarity). Isoform 2 also is a component of dynactin complex from brain, which contains the actin-related protein ARP1.
messages: I band
messages: Isoform 1 is detected in pectoral muscle, cardiac muscle and gizzard. Isoform 2 is detected in brain and liver (at protein level). Isoform 2 is the predominant isoform of nonmuscle tissues and isoform 1 is the predominant isoform of muscle tissues.
messages: Z line
messages: cytoskeleton

9031:IFNAR2
gene id: 9031:IFNAR2
uniprot id: Q9YHV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

9031:POLR3A
gene id: 9031:POLR3A
uniprot id: Q5ZL98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
messages: Nucleus

9031:MRPL53
gene id: 9031:MRPL53
uniprot id: A0A1D5PKK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

9031:EIF4EBP2
gene id: 9031:EIF4EBP2
uniprot id: A0A1L1RKV7
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9031:PSMD11
gene id: 9031:PSMD11
uniprot id: F1NPA2
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

9031:MED1
gene id: 9031:MED1
uniprot id: E1BUI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9031:SPRTN
gene id: 9031:SPRTN
uniprot id: E1BQ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9031:FKBP5
gene id: 9031:FKBP5
uniprot id: Q646T7
names: Subcellular Location Annotation
messages: Nucleus

9031:RPL7L1
gene id: 9031:RPL7L1
uniprot id: Q5ZKA7
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9031:DIS3
gene id: 9031:DIS3
uniprot id: E1BXX6
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9031:XRCC6
gene id: 9031:XRCC6
uniprot id: O93257
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ku70 family.
messages: Chromosome
messages: Heterodimer composed of XRCC5/Ku80 and XRCC6/Ku70. Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF. Additional component of the NHEJ complex includes PAXX. Following autophosphorylation, PRKDC dissociates from DNA, leading to formation of the short-range NHEJ complex, composed of LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF.
messages: Nucleus
messages: Phosphorylated on serine residues.
messages: Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (By similarity).

9031:NPRL2
gene id: 9031:NPRL2
uniprot id: F1NY69
names: Similarity
messages: Belongs to the NPR2 family.

9031:MST1
gene id: 9031:MST1
uniprot id: Q90865
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PARVA
gene id: 9031:PARVA
uniprot id: F1P5V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

9031:CD99
gene id: 9031:CD99
uniprot id: A0A3Q3A7M3
names: Similarity
messages: Belongs to the CD99 family.

9031:LOC769000
gene id: 9031:LOC769000
uniprot id: A0A1D5NUH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:PPARG
gene id: 9031:PPARG
uniprot id: Q9I878
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9031:SUPT6H
gene id: 9031:SUPT6H
uniprot id: E1C1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

9031:NACC2
gene id: 9031:NACC2
uniprot id: Q5ZI70
names: Subcellular Location Annotation
messages: Nucleus

9031:TXLNB
gene id: 9031:TXLNB
uniprot id: F1P0Q4
uniprot id: Q9I969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the taxilin family.
messages: Cytoplasm
messages: Promotes neurite-outgrowth. May be involved in intracellular vesicle traffic.
messages: Specifically expressed in skeletal and cardiac muscle.

9031:FOXN3
gene id: 9031:FOXN3
uniprot id: A0A1D5P0G0
uniprot id: A0A1D5PF72
uniprot id: E1C4G1
names: Subcellular Location Annotation
messages: Nucleus

9031:NSF
gene id: 9031:NSF
uniprot id: E1BQU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9031:DKK3
gene id: 9031:DKK3
uniprot id: Q90839
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
messages: Belongs to the dickkopf family.
messages: Expressed in eye lens.
messages: Interacts with LRP5 and LRP6.
messages: Secreted
messages: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.

9031:LOC415664
gene id: 9031:LOC415664
uniprot id: A0A1D5P9X5
uniprot id: A0A2Z5EM90
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:MMP1
gene id: 9031:MMP1
uniprot id: E1C9D9
names: Similarity
messages: Belongs to the peptidase M10A family.

9031:FAM26F
gene id: 9031:FAM26F
uniprot id: E1C3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9031:GAS8
gene id: 9031:GAS8
uniprot id: F1NLA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum axoneme

9031:B3GNT5
gene id: 9031:B3GNT5
uniprot id: A0A1D5PGR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:LYVE1
gene id: 9031:LYVE1
uniprot id: E1C9I1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SKIL
gene id: 9031:SKIL
uniprot id: Q05951
names: Similarity
messages: Belongs to the SKI family.

9031:ROCK1
gene id: 9031:ROCK1
uniprot id: A0A1D5PK41
uniprot id: F1NRH6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9031:KCNK7
gene id: 9031:KCNK7
uniprot id: F1NP03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9031:CDC14B
gene id: 9031:CDC14B
uniprot id: A0A1D5PXT4
uniprot id: D5K9Y4
uniprot id: R4GK00
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

9031:LSAMP
gene id: 9031:LSAMP
uniprot id: Q98919
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. IgLON family.
messages: Cell membrane
messages: Mediates selective neuronal growth and axon targeting. Probably serves as a recognition molecule for the formation of limbic connections (By similarity).

9031:TNPO1
gene id: 9031:TNPO1
uniprot id: A0A3Q3AHG4
names: Subcellular Location Annotation
messages: Cytoplasm

9031:NGB
gene id: 9031:NGB
uniprot id: Q5QSB1
names: Similarity
messages: Belongs to the globin family.

9031:TIMM8A
gene id: 9031:TIMM8A
uniprot id: F1NIC5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9031:BRPF1
gene id: 9031:BRPF1
uniprot id: Q5F3S4
names: Subcellular Location Annotation
messages: Nucleus

9031:WDR59
gene id: 9031:WDR59
uniprot id: Q5ZLG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Belongs to the WD repeat WDR59 family.
messages: Lysosome membrane
messages: Probably part of the GATOR complex.

9031:ROGDI
gene id: 9031:ROGDI
uniprot id: F1NFQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Perikaryon
messages: Presynapse
messages: synaptic vesicle

9031:DNAAF2
gene id: 9031:DNAAF2
uniprot id: F1NI98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

9031:LOC396479
gene id: 9031:LOC396479
uniprot id: A0A1D5P8J9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:VIM
gene id: 9031:VIM
uniprot id: F1NJ08
names: Function
names: Similarity
messages: Belongs to the intermediate filament family.
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

9031:SCN3B
gene id: 9031:SCN3B
uniprot id: E1BZ61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9031:PIGU
gene id: 9031:PIGU
uniprot id: E1BST8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:NARF
gene id: 9031:NARF
uniprot id: E1BYV6
names: Similarity
messages: Belongs to the NARF family.

9031:NSMCE1
gene id: 9031:NSMCE1
uniprot id: E1BWX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9031:MRPL33
gene id: 9031:MRPL33
uniprot id: A0A3Q2ULJ2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

9031:UBR1
gene id: 9031:UBR1
uniprot id: F1P5I1
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9031:MKNK1
gene id: 9031:MKNK1
uniprot id: F1N9J6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:BCL9
gene id: 9031:BCL9
uniprot id: A0A1D5PQ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9031:REL
gene id: 9031:REL
uniprot id: P16236
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex. Component of the NF-KAPPA-B p65-c-Rel complex.
messages: Nucleus
messages: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator (By similarity).

9031:FGFR3
gene id: 9031:FGFR3
uniprot id: P18460
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Monomer. Homodimer after ligand binding (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans.
messages: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).

9031:BTD
gene id: 9031:BTD
uniprot id: E1C3J7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9031:KCNA10
gene id: 9031:KCNA10
uniprot id: Q7T199
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily.
messages: Detected in brain, cochlear sensory epithelium, cochlear ganglion, tegumentum vasculosum. Detected at low levels in cochlear lagena.
messages: First detected at very low levels at embryonic day 6. Detected at embryonic day 9 and 14, and 3 days after hatching.
messages: Homotetramer.
messages: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP (By similarity).
messages: Membrane
messages: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

9031:MRPL40
gene id: 9031:MRPL40
uniprot id: A0A3Q2UG94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

9031:FAM214B
gene id: 9031:FAM214B
uniprot id: E1BRK3
names: Similarity
messages: Belongs to the FAM214 family.

9031:RHAG
gene id: 9031:RHAG
uniprot id: F1NFG6
uniprot id: Q7T066
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9031:UROS
gene id: 9031:UROS
uniprot id: E1BUH1
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

9031:COPS5
gene id: 9031:COPS5
uniprot id: Q5ZLC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

9031:GUCA1A
gene id: 9031:GUCA1A
uniprot id: P79880
names: Domain
names: Function
names: Tissue Specificity
messages: Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high (PubMed:17997965). Binds Mg(2+) when calcium levels are low.
messages: Retina, in rod and cone outer segments, and pineal gland.
messages: Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure.

9031:CXXC5
gene id: 9031:CXXC5
uniprot id: F1NCW6
names: Subcellular Location Annotation
messages: Cytoplasm

9031:HIST1H2BO
gene id: 9031:HIST1H2BO
uniprot id: P0C1H3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct.
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:BDKRB2
gene id: 9031:BDKRB2
uniprot id: O42402
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9031:GRIA1
gene id: 9031:GRIA1
uniprot id: A0A1D5PIW7
uniprot id: Q90855
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:GNG10
gene id: 9031:GNG10
uniprot id: E1C795
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9031:CD8A
gene id: 9031:CD8A
uniprot id: F1NXT4
uniprot id: Q90770
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:IGF2BP3
gene id: 9031:IGF2BP3
uniprot id: Q5ZLP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: All KH domains contribute binding to target mRNA. Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 also contribute. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.
messages: Belongs to the RRM IMP/VICKZ family.
messages: Cytoplasm
messages: Homodimer and multimer.
messages: Nucleus
messages: P-body
messages: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability.
messages: Stress granule

9031:AvBD4
gene id: 9031:AvBD4
uniprot id: Q6GXJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis.
messages: Secreted
messages: Strong expression in the bone marrow and testis. Widely expressed. Weak expression in the ovarian stroma, but not expressed in the ovarian follicles.

9031:NDP
gene id: 9031:NDP
uniprot id: E1BWM4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:GPR158
gene id: 9031:GPR158
uniprot id: F1NUT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9031:PTGR1
gene id: 9031:PTGR1
uniprot id: Q5ZII4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9031:ZDHHC12
gene id: 9031:ZDHHC12
uniprot id: A0A3Q2U323
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:KCMF1
gene id: 9031:KCMF1
uniprot id: F1NKH2
names: Function
names: Similarity
messages: Belongs to the KCMF1 family.
messages: Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.

9031:PRPF4
gene id: 9031:PRPF4
uniprot id: F1NNQ9
names: Subcellular Location Annotation
messages: Nucleus speckle

9031:MTTP
gene id: 9031:MTTP
uniprot id: A0A1D5PVM0
uniprot id: M9QWS9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SLC25A46
gene id: 9031:SLC25A46
uniprot id: Q5ZIG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion outer membrane
messages: Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission.

9031:LZIC
gene id: 9031:LZIC
uniprot id: Q5ZKW2
names: Similarity
names: Subunit
messages: Belongs to the CTNNBIP1 family.
messages: Does not interact with CTNNB1.

9031:TYW1
gene id: 9031:TYW1
uniprot id: F1NVK4
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

9031:STK11
gene id: 9031:STK11
uniprot id: Q0GGW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
messages: Catalytic component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta).
messages: Cytoplasm
messages: Nucleus
messages: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity).
messages: Ubiquitously expressed in all tissues tested. High levels were observed in duodenum and skeletal muscle, lower levels in liver and pancreas.

9031:LOC100859586
gene id: 9031:LOC100859586
uniprot id: A0A1D5PAN7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:ALDH4A1
gene id: 9031:ALDH4A1
uniprot id: A0A1D5PXI1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9031:MC1R
gene id: 9031:MC1R
uniprot id: Q59I39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9031:RFTN1
gene id: 9031:RFTN1
uniprot id: Q7SZI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.

9031:TIRAP
gene id: 9031:TIRAP
uniprot id: Q4U127
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

9031:YIPF3
gene id: 9031:YIPF3
uniprot id: Q5F384
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity).
messages: cis-Golgi network membrane

9031:PSMC6
gene id: 9031:PSMC6
uniprot id: Q5ZKX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9031:ELOVL7
gene id: 9031:ELOVL7
uniprot id: E1C102
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:LRP3
gene id: 9031:LRP3
uniprot id: A0A3Q2U4Z0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:HSPB2
gene id: 9031:HSPB2
uniprot id: Q6KCP2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9031:FGF14
gene id: 9031:FGF14
uniprot id: A0A3Q3A899
uniprot id: Q9IAI5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:HMG20A
gene id: 9031:HMG20A
uniprot id: Q5ZKF4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in neuronal differentiation.

9031:SMC2
gene id: 9031:SMC2
uniprot id: Q90988
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
messages: Chromosome
messages: Cytoplasm
messages: Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and probably some non SMC subunits that regulate the complex.
messages: Nucleus
messages: The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.

9031:PCK2
gene id: 9031:PCK2
uniprot id: P21642
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears to be constitutively expressed.
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver.
messages: In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one. In birds, PEPCK-M is the sole form of hepatic PEPCK, but it constitutes 60% of the enzyme in the kidney.
messages: Mitochondrion
messages: Monomer.
messages: Present in liver and kidney.

9031:SGF29
gene id: 9031:SGF29
uniprot id: Q5ZL38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF29 family.
messages: Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (By similarity). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Also binds non-histone proteins that are methylated on Lys residues (By similarity).
messages: Interacts with dimethylated and trimethylated 'Lys-4' of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3). Component of some SAGA-type complexes. Component of the ADA2A-containing complex (ATAC).
messages: Nucleus
messages: The SGF29 C-terminal (also named tudor-like) domain mediates binding to methylated 'Lys-4' of histone H3 (H3K4me).

9031:ARID5B
gene id: 9031:ARID5B
uniprot id: A0A1D5PYH5
uniprot id: Q5ZJ69
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARID5B family.
messages: Nucleus
messages: The ARID domain mediates the interaction with DNA.
messages: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes (By similarity).

9031:RNF43
gene id: 9031:RNF43
uniprot id: E1BQX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

9031:LOC101748830
gene id: 9031:LOC101748830
uniprot id: A0A3Q2TWC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9031:PRLHR2
gene id: 9031:PRLHR2
uniprot id: B1NWL4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:LOC418813
gene id: 9031:LOC418813
uniprot id: A0A3Q2UIQ3
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:EXOG
gene id: 9031:EXOG
uniprot id: F1NCN1
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9031:DIMT1
gene id: 9031:DIMT1
uniprot id: E1C0U9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9031:CCDC167
gene id: 9031:CCDC167
uniprot id: F1NAT1
names: Subcellular Location Annotation
messages: Membrane

9031:SLC9A3R1
gene id: 9031:SLC9A3R1
uniprot id: Q5ZM14
names: Function
names: Subcellular Location Annotation
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity).
messages: filopodium
messages: microvillus
messages: ruffle

9031:SEC61A1
gene id: 9031:SEC61A1
uniprot id: F1NBN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:TMPRSS13
gene id: 9031:TMPRSS13
uniprot id: E1C8L4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TNS3
gene id: 9031:TNS3
uniprot id: A0A1L1RSX2
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

9031:COL4A2
gene id: 9031:COL4A2
uniprot id: F1P2Q3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

9031:SZRD1
gene id: 9031:SZRD1
uniprot id: Q5ZK25
names: Similarity
messages: Belongs to the SZRD1 family.

9031:MOCS1
gene id: 9031:MOCS1
uniprot id: F1N8A1
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9031:STAG2
gene id: 9031:STAG2
uniprot id: A0A1D5PY29
uniprot id: E1BSU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

9031:LOC107049046
gene id: 9031:LOC107049046
uniprot id: A0A1D5PR40
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9031:CNR1
gene id: 9031:CNR1
uniprot id: A0A3Q2TXF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Signaling typically involves reduction in cyclic AMP.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

9031:NTS
gene id: 9031:NTS
uniprot id: R4GFZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9031:DDB1
gene id: 9031:DDB1
uniprot id: Q805F9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of the UV-DDB complex which includes DDB1 and DDB2 (By similarity). Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, CUL4A or CUL4B and RBX1, and a substrate receptor, such as CRBN (PubMed:25043012). DDB1 may recruit specific substrate targeting subunits to the DCX complex. These substrate targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (By similarity). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (Probable). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity). May play a role in the regulation of the circadian clock (By similarity).
messages: The core of the protein consists of three WD40 beta-propeller domains.

9031:DDX18
gene id: 9031:DDX18
uniprot id: F1NEQ3
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

9031:PSMD3
gene id: 9031:PSMD3
uniprot id: Q5ZMD9
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9031:ARRDC1
gene id: 9031:ARRDC1
uniprot id: Q5ZKV5
names: Similarity
messages: Belongs to the arrestin family.

9031:SLC47A1
gene id: 9031:SLC47A1
uniprot id: A0A1D5PCR9
uniprot id: Q5ZK46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9031:ALG10
gene id: 9031:ALG10
uniprot id: Q5ZKB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

9031:CACYBP
gene id: 9031:CACYBP
uniprot id: E1BQN9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9031:C1R
gene id: 9031:C1R
uniprot id: F1NAB7
names: Caution
names: Function
names: Subunit
messages: C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.
messages: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GALNT16
gene id: 9031:GALNT16
uniprot id: F1NXH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:SESN4
gene id: 9031:SESN4
uniprot id: F1NGI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9031:MLF1
gene id: 9031:MLF1
uniprot id: A0A1D5PNX1
uniprot id: A0A1L1RRD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9031:TNS1
gene id: 9031:TNS1
uniprot id: Q04205
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PTEN phosphatase protein family.
messages: Binds to actin filaments. Interacts with phosphotyrosine-containing proteins (PubMed:1708917).
messages: Cell surface
messages: Heart, gizzard, lung and skeletal muscle.
messages: May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Plays a role in cell polarization and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton.
messages: Probable cloning artifact.
messages: Tyrosine phosphorylated.
messages: cytoskeleton
messages: focal adhesion

9031:PABIR3
gene id: 9031:PABIR3
uniprot id: Q5ZLN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint.
messages: Belongs to the FAM122 family.
messages: Cytoplasm
messages: Nucleus

9031:NAE1
gene id: 9031:NAE1
uniprot id: Q5ZIE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M (By similarity).
messages: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity).

9031:RNFT2
gene id: 9031:RNFT2
uniprot id: F1NDS9
names: Subcellular Location Annotation
messages: Membrane

9031:SLC48A1
gene id: 9031:SLC48A1
uniprot id: Q5ZHU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
messages: Lysosome membrane

9031:DDX1
gene id: 9031:DDX1
uniprot id: Q90WU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Acts as a positive regulator of transcription. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Binds DNA and RNA. Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB (By similarity). Binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Detected in embryonic retina, brain, heart and liver (at protein level). Detected in embryonic retina, brain, heart, kidney and liver.
messages: Mitochondrion
messages: Nucleus
messages: The helicase domain is involved in the stimulation of RELA transcriptional activity.
messages: cytosol

9031:RER1
gene id: 9031:RER1
uniprot id: Q5ZHM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Golgi apparatus membrane
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.

9031:POLR1E
gene id: 9031:POLR1E
uniprot id: F1NXA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

9031:PDCL3
gene id: 9031:PDCL3
uniprot id: Q5ZL90
names: Similarity
messages: Belongs to the phosducin family.

9031:USP49
gene id: 9031:USP49
uniprot id: A0A3Q2UJB4
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:PRTFDC1
gene id: 9031:PRTFDC1
uniprot id: E1C5K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

9031:ARF1
gene id: 9031:ARF1
uniprot id: Q5ZMA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9031:CRH
gene id: 9031:CRH
uniprot id: Q703P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9031:SPC25
gene id: 9031:SPC25
uniprot id: E1C4Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9031:CDT1
gene id: 9031:CDT1
uniprot id: A0A3Q2U5N8
names: Similarity
messages: Belongs to the Cdt1 family.

9031:RIOX1
gene id: 9031:RIOX1
uniprot id: Q5ZMM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. NO66 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes demethylation of non-histone proteins (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity).
messages: nucleolus
messages: nucleoplasm

9031:CDKN2AIP
gene id: 9031:CDKN2AIP
uniprot id: E1C4G6
names: Similarity
messages: Belongs to the CARF family.

9031:CUEDC2
gene id: 9031:CUEDC2
uniprot id: A0A1D5P910
uniprot id: E1C7R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9031:SLC6A4
gene id: 9031:SLC6A4
uniprot id: F1NZ44
uniprot id: Q6PWI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

9031:CCDC25
gene id: 9031:CCDC25
uniprot id: E1BRQ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9031:TSR1
gene id: 9031:TSR1
uniprot id: A0A1D5PFK0
names: Subcellular Location Annotation
messages: nucleolus

9031:LOC427416
gene id: 9031:LOC427416
uniprot id: A0A0A0MQ62
uniprot id: P56736
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the avidin/streptavidin family.
messages: Secreted

9031:RPE65
gene id: 9031:RPE65
uniprot id: Q9YGX2
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cell membrane
messages: Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:19490105). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (By similarity). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).
messages: Cytoplasm
messages: Highly expressed in the retinal pigment epithelium (RPE)/ choroid of the 21 dpc embryos (at protein level).
messages: Microsome membrane
messages: Palmitoylation by LRAT regulates ligand binding specificity; the palmitoylated form (membrane form) specifically binds all-trans-retinyl-palmitate, while the soluble unpalmitoylated form binds all-trans-retinol (vitamin A).
messages: Retinal pigment epithelium specific.

9031:MMP2
gene id: 9031:MMP2
uniprot id: Q90611
names: Cofactor
names: Domain
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 4 Ca(2+) ions per subunit.
messages: Ligand for integrin alpha-V/beta-3.
messages: Produced by normal skin fibroblasts.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3).
messages: extracellular matrix

9031:CERS1
gene id: 9031:CERS1
uniprot id: F1N9S0
names: Subcellular Location Annotation
messages: Membrane

9031:TNFAIP8
gene id: 9031:TNFAIP8
uniprot id: Q5ZI78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative mediator of apoptosis.
messages: Belongs to the TNFAIP8 family.
messages: Cytoplasm

9031:NR1H3
gene id: 9031:NR1H3
uniprot id: A0A3Q2UH91
uniprot id: Q8JHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9031:LOC100857367
gene id: 9031:LOC100857367
uniprot id: A0A3Q2TTW5
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:TSG101
gene id: 9031:TSG101
uniprot id: E1BWW2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

9031:GPI
gene id: 9031:GPI
uniprot id: Q5ZMU3
names: Similarity
messages: Belongs to the GPI family.

9031:PIK3R1
gene id: 9031:PIK3R1
uniprot id: A0A1D5PUK7
uniprot id: A0A3Q3ACS4
uniprot id: E1C8M4
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9031:TGM3
gene id: 9031:TGM3
uniprot id: A0A1D5NXS5
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9031:MRPS25
gene id: 9031:MRPS25
uniprot id: E1BSI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

9031:MAFF
gene id: 9031:MAFF
uniprot id: Q90595
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. Maf subfamily.
messages: Highly expressed in the ovary, lower expression in the brain, heart and mesenterium.
messages: Monomer and homo- or heterodimer.
messages: Nucleus
messages: Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerizes among itself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.

9031:GABRA6
gene id: 9031:GABRA6
uniprot id: Q90845
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily.
messages: Cell membrane
messages: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
messages: Postsynaptic cell membrane

9031:TFPI2
gene id: 9031:TFPI2
uniprot id: A0A3Q3A7D8
names: Subcellular Location Annotation
messages: Secreted

9031:HHIP
gene id: 9031:HHIP
uniprot id: A0A1D5PDP9
uniprot id: F1NGW6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:BTG1L
gene id: 9031:BTG1L
uniprot id: F1NFU7
names: Similarity
messages: Belongs to the BTG family.

9031:GXYLT1
gene id: 9031:GXYLT1
uniprot id: Q5ZKI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
messages: Membrane

9031:TPT1
gene id: 9031:TPT1
uniprot id: P43347
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Involved in calcium binding and microtubule stabilization.

9031:SEC13
gene id: 9031:SEC13
uniprot id: A0A1D5NYF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

9031:PRR29
gene id: 9031:PRR29
uniprot id: A0A3Q2U8N1
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9031:TNFSF8
gene id: 9031:TNFSF8
uniprot id: Q800J1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9031:PPM1B
gene id: 9031:PPM1B
uniprot id: A0A1D5PF07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9031:PPIH
gene id: 9031:PPIH
uniprot id: E1BXG0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9031:CHSY3
gene id: 9031:CHSY3
uniprot id: R4GKW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9031:MTMR9LP
gene id: 9031:MTMR9LP
uniprot id: E1C6W8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9031:SLC25A22
gene id: 9031:SLC25A22
uniprot id: A0A1D5PSP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:OLFR3A
gene id: 9031:OLFR3A
uniprot id: Q90807
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:P2RY1
gene id: 9031:P2RY1
uniprot id: P34996
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Brain, spinal cord, gastrointestinal tract, spleen and leg muscle. Is not detected in the heart, liver, stomach, lung and kidney.
messages: Cell membrane
messages: Receptor for extracellular adenine nucleotides such as ADP (PubMed:8508924). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity).

9031:MSX1
gene id: 9031:MSX1
uniprot id: P50223
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Msh homeobox family.
messages: Early limb development. First present in an asymmetric arc extending from the anterior border of the limb bud to the mesenchymal cells directly adjacent to the AER. Later abundantly expressed in the proximal anterior periphery and in the mid-proximal region of the posterior periphery. In older wing buds, detectable throughout the necrotic mesenchyme between the developing digits.
messages: Nucleus
messages: Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death.

9031:TNFRSF21
gene id: 9031:TNFRSF21
uniprot id: A0A1D5PS99
uniprot id: Q98SM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TMEM150C
gene id: 9031:TMEM150C
uniprot id: A0A3Q2TW69
names: Subcellular Location Annotation
messages: Membrane

9031:CLDN23
gene id: 9031:CLDN23
uniprot id: A0A1D5PZV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9031:TCP11L1
gene id: 9031:TCP11L1
uniprot id: F1NSD6
names: Similarity
messages: Belongs to the TCP11 family.

9031:MRRFP1
gene id: 9031:MRRFP1
uniprot id: E1BQ58
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

9031:PARD3
gene id: 9031:PARD3
uniprot id: Q0PVE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9031:USP28
gene id: 9031:USP28
uniprot id: Q5ZID5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP28 subfamily.
messages: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome. Deubiquitinates ZNF304, hence may prevent ZNF304 degradation by the proteasome, leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs).
messages: nucleoplasm

9031:EMP1
gene id: 9031:EMP1
uniprot id: E1BZ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

9031:PEX12
gene id: 9031:PEX12
uniprot id: E1BXZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

9031:LOC420860
gene id: 9031:LOC420860
uniprot id: A0A3Q2U7V5
names: Similarity
messages: Belongs to the TMEM14 family.

9031:SEC22C
gene id: 9031:SEC22C
uniprot id: A0A1D5PMC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9031:OPN4-1
gene id: 9031:OPN4-1
uniprot id: A0A1D5NZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9031:NAAA
gene id: 9031:NAAA
uniprot id: F1NCS3
names: Similarity
messages: Belongs to the acid ceramidase family.

9031:OR51M1
gene id: 9031:OR51M1
uniprot id: Q9YH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:CTCF
gene id: 9031:CTCF
uniprot id: Q08705
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as both a transcriptional activator and repressor of the MYC gene.
messages: Belongs to the CTCF zinc-finger protein family.
messages: Nucleus

9031:EGFR
gene id: 9031:EGFR
uniprot id: A0A1D5PKH0
uniprot id: P13387
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation.
messages: Cell membrane
messages: Endocytosis and inhibition of the activated EGFR by phosphatases constitute immediate regulatory mechanisms. Moreover, inducible feedback inhibitors may constitute alternative regulatory mechanisms for the EGFR signaling.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylated. Autophosphorylates.
messages: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:3260329). Known ligands include EGF and TGFA/TGF-alpha (PubMed:3260329). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (By similarity). May also activate the NF-kappa-B signaling cascade (By similarity).

9031:DLX5
gene id: 9031:DLX5
uniprot id: P50577
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus
messages: Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA.

9031:TMEM177
gene id: 9031:TMEM177
uniprot id: E1BWW7
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

9031:ST8SIA5
gene id: 9031:ST8SIA5
uniprot id: A0A1D5PIR8
uniprot id: A0A3Q2TZK0
uniprot id: Q6ZX98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:CDC37L1
gene id: 9031:CDC37L1
uniprot id: F1NH83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9031:SNRPD1
gene id: 9031:SNRPD1
uniprot id: A0A1D5PGA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

9031:SUGP1
gene id: 9031:SUGP1
uniprot id: A0A1D5P6Z4
names: Subcellular Location Annotation
messages: Nucleus

9031:CTTN
gene id: 9031:CTTN
uniprot id: Q01406
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Acetylated.
messages: Cell junction
messages: Cell membrane
messages: Cell projection
messages: Contributes to the organization of the actin cytoskeleton and cell shape (By similarity). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones, and may play a role in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (By similarity). Plays a role in endocytosis via clathrin-coated pits (By similarity).
messages: Endoplasmic reticulum
messages: In normal cells, appears to be phosphorylated on serine and threonine; in cells expressing activated forms of pp60-src, they become heavily phosphorylated on tyrosine in vitro. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
messages: The SH3 motif may mediate binding to the cytoskeleton.
messages: cell cortex
messages: clathrin-coated pit
messages: cytoskeleton
messages: dendrite
messages: dendritic spine
messages: focal adhesion
messages: lamellipodium
messages: podosome
messages: ruffle

9031:MALL
gene id: 9031:MALL
uniprot id: E1BXC7
names: Subcellular Location Annotation
messages: Membrane

9031:PTPRS
gene id: 9031:PTPRS
uniprot id: F1NWE3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
messages: Cell membrane
messages: Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:11865065, PubMed:17178832). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:17967490). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:17967490). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (PubMed:17967490). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (By similarity).
messages: Detected in embryonic brain, dorsal root ganglion and spinal cord (PubMed:7600997). Detected in embryonic retina (at protein level) (PubMed:11865065). Detected in embryonic brain, spinal cord, dorsal root ganglion, trigeminal ganglion, ganglia associated with the precardinal vein and vagus nerve, the inner and outer nuclear layer of the retina, limb, breast muscle, heart, gut and lung.
messages: Homodimer (PubMed:17178832). Binding to large heparan sulfate proteoglycan structures promotes oligomerization. Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (By similarity). Interacts (via Ig-like domains) with NTRK1 and NTRK3, but does not form detectable complexes with NTRK2 (PubMed:17967490, PubMed:25385546). Interacts (via extracellular domain) with the heparan sulfate proteoglycans AGRN and COL18A1 (PubMed:11865065).
messages: Perikaryon
messages: Postsynaptic density
messages: axon
messages: growth cone
messages: neuron projection
messages: synaptic vesicle membrane
messages: synaptosome

9031:KCNQ2
gene id: 9031:KCNQ2
uniprot id: A0A3Q2UDK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TFAP2C
gene id: 9031:TFAP2C
uniprot id: E1C5K7
names: Similarity
messages: Belongs to the AP-2 family.

9031:SIAH1
gene id: 9031:SIAH1
uniprot id: F1P2G0
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9031:CALHM2
gene id: 9031:CALHM2
uniprot id: E1C257
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9031:SPEG
gene id: 9031:SPEG
uniprot id: A0A3Q2U9K9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

9031:RORA
gene id: 9031:RORA
uniprot id: A0A3Q2UCE3
uniprot id: F1NML9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:TATDN3
gene id: 9031:TATDN3
uniprot id: F1P548
names: Subcellular Location Annotation
messages: Membrane

9031:NBL1
gene id: 9031:NBL1
uniprot id: A0A1N8XHL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

9031:TUBB1
gene id: 9031:TUBB1
uniprot id: P09207
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Highly expressed in bone marrow.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:SS18L2
gene id: 9031:SS18L2
uniprot id: E1BUW3
names: Similarity
messages: Belongs to the SS18 family.

9031:LOC107051909
gene id: 9031:LOC107051909
uniprot id: A0A1D5NYU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

9031:CNTNAP5
gene id: 9031:CNTNAP5
uniprot id: F1NW79
uniprot id: Q0V8S9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Expressed in brain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.
messages: Membrane

9031:SLC39A6
gene id: 9031:SLC39A6
uniprot id: A0A3Q2U1P1
names: Subcellular Location Annotation
messages: Membrane

9031:MCM9
gene id: 9031:MCM9
uniprot id: A0A0A0MQ52
uniprot id: I0IUP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MCM family.
messages: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.
messages: Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9.
messages: Nucleus

9031:LMBRD1
gene id: 9031:LMBRD1
uniprot id: Q5ZI05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). May play a role in mediating and regulating the internalization of the insulin receptor (By similarity).
messages: Lysosome membrane

9031:HSDL2
gene id: 9031:HSDL2
uniprot id: E1C7S2
names: Subcellular Location Annotation
messages: Peroxisome

9031:NDUFB2
gene id: 9031:NDUFB2
uniprot id: A0A1D5PRB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:NKX2-5
gene id: 9031:NKX2-5
uniprot id: Q90788
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NK-2 homeobox family.
messages: Homodimer (via the homeobox); binds DNA as homodimer.
messages: Nucleus
messages: The homeobox domain binds to double-stranded DNA.
messages: Transcription factor required for the development of the heart and the spleen. Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter.

9031:PTK7
gene id: 9031:PTK7
uniprot id: Q91048
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Expressed in bone marrow, spleen, bursa, thymus and brain. Weakly expressed in fibroblasts. Also expressed in embryonic liver.
messages: Inactive tyrosine kinase involved in Wnt signaling. pathway (By similarity).
messages: Membrane
messages: The protein kinase domain is predicted to be catalytically inactive.

9031:TAX1BP3
gene id: 9031:TAX1BP3
uniprot id: F1NK54
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9031:TBCD
gene id: 9031:TBCD
uniprot id: A0A1D5NTW7
uniprot id: E1BU18
uniprot id: Q5ZI87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCD family.
messages: Cytoplasm
messages: Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with PPP2CB (By similarity). Part of a supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Interacts with ARL2; interaction is enhanced with the GDP-bound form of ARL2. Does not interact with ARL3, ARL4A and ARL4D. Interacts with beta tubulin. Interacts with TBCE (By similarity).
messages: Lateral cell membrane
messages: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis.
messages: adherens junction
messages: centrosome
messages: tight junction

9031:YAF2
gene id: 9031:YAF2
uniprot id: Q5ZKC5
names: Subcellular Location Annotation
messages: Nucleus

9031:SELENOI2
gene id: 9031:SELENOI2
uniprot id: A0A3Q2UEY3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

9031:DGKB
gene id: 9031:DGKB
uniprot id: A0A1D5PLX8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9031:SLC6A19
gene id: 9031:SLC6A19
uniprot id: F1NPI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:DRAM2
gene id: 9031:DRAM2
uniprot id: A0A1D5PCK5
names: Subcellular Location Annotation
messages: Membrane

9031:RIDA
gene id: 9031:RIDA
uniprot id: A0A1L1RZS5
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

9031:KCNK9
gene id: 9031:KCNK9
uniprot id: A0A1D5PDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

9031:NTN3
gene id: 9031:NTN3
uniprot id: A0A3Q2TWG9
uniprot id: Q90923
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Netrins control guidance of CNS commissural axons and peripheral motor axons.
messages: extracellular matrix

9031:THRSPB
gene id: 9031:THRSPB
uniprot id: Q6Q125
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9031:WRB
gene id: 9031:WRB
uniprot id: F6R8U4
uniprot id: Q5ZJM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:MTO1
gene id: 9031:MTO1
uniprot id: A0A1D5PM29
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

9031:CXCL12
gene id: 9031:CXCL12
uniprot id: Q6T7B9
uniprot id: Q6T7C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9031:C8A
gene id: 9031:C8A
uniprot id: F1NJU5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:LOC100857439
gene id: 9031:LOC100857439
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:DUSP8
gene id: 9031:DUSP8
uniprot id: E1C2M2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9031:ARMC8
gene id: 9031:ARMC8
uniprot id: A0A1D5PP06
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:SPO11
gene id: 9031:SPO11
uniprot id: A0A1D5P8F2
names: Similarity
messages: Belongs to the TOP6A family.

9031:SMARCA2
gene id: 9031:SMARCA2
uniprot id: Q90755
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9031:PRPF3
gene id: 9031:PRPF3
uniprot id: Q5ZJ85
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the precatalytic spliceosome (spliceosome B complex) (By similarity). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (By similarity). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9031:USP4
gene id: 9031:USP4
uniprot id: Q5ZKD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus

9031:NAT
gene id: 9031:NAT
uniprot id: P12275
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9031:ADPRHL2
gene id: 9031:ADPRHL2
uniprot id: Q5ZI51
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (By similarity). Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
messages: Belongs to the ADP-ribosylglycohydrolase family.
messages: Binds 2 magnesium ions per subunit.
messages: Chromosome
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: The protein undergoes a dramatic conformational switch from closed to open states upon substrate-binding, which enables specific substrate recognition for the 1''-O-linkage. The glutamate flap (Glu-41) blocks substrate entrance to Mg(2+) in the unliganded closed state. In presence of substrate, Glu-41 is ejected from the active site: this closed-to-open transition significantly widens the substrate-binding channel and precisely positions the scissile 1''-O-linkage for cleavage while securing tightly 2'- and 3'-hydroxyls of ADP-ribose.

9031:CTLA4
gene id: 9031:CTLA4
uniprot id: Q1XDY5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9031:HOXA7
gene id: 9031:HOXA7
uniprot id: Q90VZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:TNFRSF8
gene id: 9031:TNFRSF8
uniprot id: Q800I0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CDADC1
gene id: 9031:CDADC1
uniprot id: A0A1D5NZE1
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

9031:MAB21L1
gene id: 9031:MAB21L1
uniprot id: Q8AY65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mab-21 family.
messages: Monomer. Homodecamer; composed of 2 back to back homopentamers. The protein may exist as monomer in solution and oiligomerizes upon ligand binding.
messages: Nucleus
messages: Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity).

9031:GRB10
gene id: 9031:GRB10
uniprot id: A0A1D5P405
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9031:LOC423731
gene id: 9031:LOC423731
uniprot id: F1P225
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9031:TWF1
gene id: 9031:TWF1
uniprot id: Q5ZLN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9031:LOC429682
gene id: 9031:LOC429682
uniprot id: A0A1D5PHT2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9031:DECR2
gene id: 9031:DECR2
uniprot id: F1NG68
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9031:COLEC12
gene id: 9031:COLEC12
uniprot id: Q2LK54
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Membrane
messages: Scavenger receptor that displays several functions associated with host defense. Binds to carbohydrates (By similarity).
messages: Widely expressed.

9031:PRPH2L
gene id: 9031:PRPH2L
uniprot id: F1NF05
uniprot id: O42282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9031:RPS3A
gene id: 9031:RPS3A
uniprot id: F2Z4K7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Cytoplasm

9031:PCDHA3
gene id: 9031:PCDHA3
uniprot id: Q6R0I8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:CRYBA4
gene id: 9031:CRYBA4
uniprot id: P49152
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9031:KLHL21
gene id: 9031:KLHL21
uniprot id: A0A1D5PKW3
names: Subcellular Location Annotation
messages: spindle

9031:INTS10
gene id: 9031:INTS10
uniprot id: A0A1I7Q410
uniprot id: Q5ZLS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 10 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

9031:CLPTM1L
gene id: 9031:CLPTM1L
uniprot id: F1NME5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

9031:NOG
gene id: 9031:NOG
uniprot id: O93525
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: At stage 8 (4-6 somites) expressed in two prominent regions, the notochord and the one posterior to Hensen node. At stage 14 (20 somites) expressed in the lateral border of the segmental plate. As the somite stage proceeds, detected in the lateral and medial portion of a young and old somite respectively and is also localized in the notochord and the roof plate of the neural tube.
messages: Belongs to the noggin family.
messages: By sonic ectopic hedgehog.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis.
messages: Secreted

9031:CHRNB3
gene id: 9031:CHRNB3
uniprot id: F1NKI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:SNX11
gene id: 9031:SNX11
uniprot id: H9L0R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9031:ACSL6
gene id: 9031:ACSL6
uniprot id: F1P2G8
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

9031:MCCC2L
gene id: 9031:MCCC2L
uniprot id: Q5ZMS5
names: Similarity
messages: Belongs to the AccD/PCCB family.

9031:AMOTL1
gene id: 9031:AMOTL1
uniprot id: A0A1D5P206
names: Similarity
messages: Belongs to the angiomotin family.

9031:BRINP3
gene id: 9031:BRINP3
uniprot id: A0A1D5NVI6
names: Similarity
messages: Belongs to the BRINP family.

9031:PSMB2
gene id: 9031:PSMB2
uniprot id: R4GLB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9031:PGA5
gene id: 9031:PGA5
uniprot id: Q9PRG9
names: Similarity
messages: Belongs to the peptidase A1 family.

9031:AQP4
gene id: 9031:AQP4
uniprot id: F1NTP3
uniprot id: Q65YQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:FAM134C
gene id: 9031:FAM134C
uniprot id: A0A3Q2UKZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9031:FFAR2L
gene id: 9031:FFAR2L
uniprot id: A0A0C4WMI0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:HSF3
gene id: 9031:HSF3
uniprot id: A0A1D5PS43
uniprot id: P38531
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HSF family.
messages: Cytoplasm
messages: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF3 binds DNA constitutively only when the C-terminal region is deleted.
messages: Expressed during development.
messages: Expressed in most tissues. High levels are found in erythrocytes and low levels in liver.
messages: Homotrimer.
messages: Nucleus

9031:VPS16
gene id: 9031:VPS16
uniprot id: A0A1D5PZL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9031:SAXO2
gene id: 9031:SAXO2
uniprot id: F1NE52
names: Similarity
messages: Belongs to the FAM154 family.

9031:TOP2B
gene id: 9031:TOP2B
uniprot id: A0A3Q2U225
uniprot id: E1BZ19
uniprot id: O42131
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation.
messages: Nucleus
messages: nucleolus
messages: nucleoplasm

9031:MYBL2
gene id: 9031:MYBL2
uniprot id: Q03237
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the DREAM complex.
messages: Expressed in hematopoietic and non hematopoietic cells.
messages: Nucleus
messages: Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family.

9031:CACTIN
gene id: 9031:CACTIN
uniprot id: E1BVV9
names: Similarity
messages: Belongs to the CACTIN family.

9031:PPAT
gene id: 9031:PPAT
uniprot id: P28173
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9031:HIST1H4I
gene id: 9031:HIST1H4I
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:SRP68
gene id: 9031:SRP68
uniprot id: Q5ZJ33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

9031:ASXL3
gene id: 9031:ASXL3
uniprot id: A0A3Q3A403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

9031:TMSB15B
gene id: 9031:TMSB15B
uniprot id: Q0GFE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9031:FAM206A
gene id: 9031:FAM206A
uniprot id: Q5ZHW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.
messages: Belongs to the ABITRAM family.
messages: Nucleus
messages: Nucleus speckle
messages: dendrite
messages: growth cone
messages: lamellipodium

9031:FLNB
gene id: 9031:FLNB
uniprot id: A0A1D5NYG3
uniprot id: A0A1D5PXM1
names: Similarity
messages: Belongs to the filamin family.

9031:GPNMB
gene id: 9031:GPNMB
uniprot id: F1NPS6
names: Similarity
messages: Belongs to the PMEL/NMB family.

9031:HSD17B4
gene id: 9031:HSD17B4
uniprot id: A0A1D5NWL9
uniprot id: O42484
names: Subcellular Location Annotation
messages: Peroxisome

9031:H3F3C
gene id: 9031:H3F3C
uniprot id: P84247
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me). Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9031:FGF1
gene id: 9031:FGF1
uniprot id: A0A2L2DDN9
uniprot id: P19596
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9031:CNN2
gene id: 9031:CNN2
uniprot id: Q5ZKU6
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

9031:GLI2
gene id: 9031:GLI2
uniprot id: A0A1D5NUY9
uniprot id: A0A1D5P8Y5
uniprot id: A5AA28
uniprot id: F1P5L2
uniprot id: Q9PSZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9031:CPN1
gene id: 9031:CPN1
uniprot id: E1C7M0
names: Similarity
messages: Belongs to the peptidase M14 family.

9031:PADI2
gene id: 9031:PADI2
uniprot id: S6BNL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9031:NPRL3
gene id: 9031:NPRL3
uniprot id: A0A1D5PQD7
uniprot id: A0A3Q2U831
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

9031:ACLY
gene id: 9031:ACLY
uniprot id: A0A1D5PSE5
uniprot id: Q5F3V2
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9031:PHLDA2
gene id: 9031:PHLDA2
uniprot id: A0A1D5P316
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ADD3
gene id: 9031:ADD3
uniprot id: F1NEA1
uniprot id: Q8AVB3
uniprot id: R4GKQ7
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9031:TECTB
gene id: 9031:TECTB
uniprot id: P54097
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Exclusively expressed in the inner ear, where it is found in basilar papilla, clear cells, supporting cells, cuboidal cells and the lagena macula.
messages: May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.
messages: N-glycosylated.
messages: One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
messages: The N-terminus is blocked.
messages: The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.
messages: Zona pellucida domain may enable to form filaments.
messages: extracellular matrix

9031:TMEM199
gene id: 9031:TMEM199
uniprot id: E1BVM0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:ANKZF1
gene id: 9031:ANKZF1
uniprot id: A0A3Q2UI41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

9031:DPYSL2
gene id: 9031:DPYSL2
uniprot id: Q71SG2
uniprot id: Q90635
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Detected in the developing chick nervous system.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1 (By similarity).
messages: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity).

9031:BGLAP
gene id: 9031:BGLAP
uniprot id: A0A1D5PRL0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9031:NFYB
gene id: 9031:NFYB
uniprot id: P25207
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity).
messages: Nucleus

9031:FAM110C
gene id: 9031:FAM110C
uniprot id: E1BRA4
names: Similarity
messages: Belongs to the FAM110 family.

9031:INPP4A
gene id: 9031:INPP4A
uniprot id: A0A1D5PSA2
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9031:MPC2
gene id: 9031:MPC2
uniprot id: F1NU06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9031:CHRNA3
gene id: 9031:CHRNA3
uniprot id: P09481
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily.
messages: Cell membrane
messages: High levels in the developing ciliary and superior cervical ganglia.
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
messages: Postsynaptic cell membrane

9031:MAP3K13
gene id: 9031:MAP3K13
uniprot id: A0A1D5P0M9
uniprot id: E1C1Y9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9031:CDIN1
gene id: 9031:CDIN1
uniprot id: Q5F476
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May play a role in erythroid cell differentiation.
messages: Nucleus

9031:EXOC7
gene id: 9031:EXOC7
uniprot id: E1BT75
uniprot id: F6QPE3
uniprot id: Q5ZIN3
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9031:EOMES
gene id: 9031:EOMES
uniprot id: R4GH67
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:PGP
gene id: 9031:PGP
uniprot id: Q5F4B1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.
messages: Homodimer.

9031:IVD
gene id: 9031:IVD
uniprot id: A0A1D5P5B2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9031:NME1
gene id: 9031:NME1
uniprot id: F1N910
names: Similarity
messages: Belongs to the NDK family.

9031:LBR
gene id: 9031:LBR
uniprot id: P23913
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG4/ERG24 family.
messages: Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (By similarity). Anchors the lamina and the heterochromatin to the inner nuclear membrane (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with DNA (By similarity). Interaction with DNA is sequence independent with higher affinity for supercoiled and relaxed circular DNA than linear DNA (By similarity).
messages: Nucleus
messages: Nucleus inner membrane
messages: The Tudor domain may not recognize methylation marks, but rather bind unassembled free histone H3.

9031:CLN8
gene id: 9031:CLN8
uniprot id: A0A1D5NZY8
names: Subcellular Location Annotation
messages: Membrane

9031:MFSD6
gene id: 9031:MFSD6
uniprot id: A0A1D5PYB6
uniprot id: A0A3Q2U5G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9031:NPW
gene id: 9031:NPW
uniprot id: A0A172PWX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

9031:TPP1
gene id: 9031:TPP1
uniprot id: A0A1D5P1E1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CPEB4
gene id: 9031:CPEB4
uniprot id: A0A1D5P1V7
uniprot id: A0A1D5PET4
names: Similarity
messages: Belongs to the RRM CPEB family.

9031:RPS27A
gene id: 9031:RPS27A
uniprot id: P79781
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Ribosomal protein S27a is a component of the 40S subunit of the ribosome.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.
messages: Ubiquitin Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

9031:SASS6
gene id: 9031:SASS6
uniprot id: Q5ZMV2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity).
messages: Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets.
messages: The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
messages: centrosome

9031:NIPA2
gene id: 9031:NIPA2
uniprot id: F1NBX2
uniprot id: Q8AY37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9031:EFHC2
gene id: 9031:EFHC2
uniprot id: A0A0A0MQ56
names: Subcellular Location Annotation
messages: cilium axoneme

9031:RNF170
gene id: 9031:RNF170
uniprot id: D5M8S4
names: Subcellular Location Annotation
messages: Membrane

9031:TTYH3
gene id: 9031:TTYH3
uniprot id: F1NWU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9031:HYOU1
gene id: 9031:HYOU1
uniprot id: Q5ZLK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen
messages: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

9031:GGPS1
gene id: 9031:GGPS1
uniprot id: A0A1D5NWX3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9031:TOP3B
gene id: 9031:TOP3B
uniprot id: Q5ZK71
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9031:GLI1
gene id: 9031:GLI1
uniprot id: A0A1D5P9C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9031:SPTBN1
gene id: 9031:SPTBN1
uniprot id: A0A1D5P797
uniprot id: A0A1D5PJY1
names: Similarity
messages: Belongs to the spectrin family.

9031:CUL3
gene id: 9031:CUL3
uniprot id: E1BYQ3
names: Similarity
messages: Belongs to the cullin family.

9031:CPNE8
gene id: 9031:CPNE8
uniprot id: F1NGI7
names: Similarity
messages: Belongs to the copine family.

9031:ATP6V1E1
gene id: 9031:ATP6V1E1
uniprot id: Q5ZKJ9
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9031:PIK3R3
gene id: 9031:PIK3R3
uniprot id: E1C8M6
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9031:HAPLN1
gene id: 9031:HAPLN1
uniprot id: P07354
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAPLN family.
messages: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
messages: extracellular matrix

9031:SLC25A3
gene id: 9031:SLC25A3
uniprot id: A0A3S5ZPB7
uniprot id: Q5ZLZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

9031:CSRNP2
gene id: 9031:CSRNP2
uniprot id: A0A1D5PNW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9031:FGF16
gene id: 9031:FGF16
uniprot id: Q197G3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:DDX20
gene id: 9031:DDX20
uniprot id: F1P5C0
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:SCNN1A
gene id: 9031:SCNN1A
uniprot id: Q92075
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties.
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
messages: The long isoform has been found in cochlea, colon, and cartilage. The short isoform is only found in cochlea.
messages: acrosome
messages: cilium
messages: flagellum

9031:COX6C
gene id: 9031:COX6C
uniprot id: A0A1D5PN05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9031:MYH1C
gene id: 9031:MYH1C
uniprot id: Q9DGM4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:PDS5B
gene id: 9031:PDS5B
uniprot id: Q5F3U9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the cohesin complex.
messages: Nucleus
messages: Plays a role in androgen-induced proliferative arrest. Required for maintenance of sister chromatid cohesion during mitosis (By similarity).

9031:MAL2
gene id: 9031:MAL2
uniprot id: A0A1D5PRH9
uniprot id: Q5F3S0
names: Subcellular Location Annotation
messages: Membrane

9031:CCN3
gene id: 9031:CCN3
uniprot id: P28686
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CCN family.
messages: Brain and heart, and at a lower level in muscle and intestine, in the embryo. Lung and less so in brain and spleen, in adult chicken.
messages: Cytoplasm
messages: Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro.
messages: MAV1-induced nephroblastomas express a high level of NOV gene whose transcription is normally arrested in adult kidney.
messages: Secreted
messages: gap junction

9031:LRP1
gene id: 9031:LRP1
uniprot id: P98157
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LDLR family.
messages: Binds vitellogenin and LRPAP1 (alpha 2-macroglobulin).
messages: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated.
messages: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor.
messages: Membrane
messages: Somatic.
messages: coated pit

9031:MCM3
gene id: 9031:MCM3
uniprot id: Q5ZMN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus

9031:MTAP
gene id: 9031:MTAP
uniprot id: F1NCV7
uniprot id: Q5ZHQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9031:CACHD1
gene id: 9031:CACHD1
uniprot id: F1NML1
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9031:LOC107057539
gene id: 9031:LOC107057539
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:PAH
gene id: 9031:PAH
uniprot id: Q6PKI8
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9031:CTSS
gene id: 9031:CTSS
uniprot id: Q5ZMR6
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:TPPP
gene id: 9031:TPPP
uniprot id: A0A1D5P4Y0
names: Similarity
messages: Belongs to the TPPP family.

9031:ZC3H12A
gene id: 9031:ZC3H12A
uniprot id: A0A1D5P3N0
names: Similarity
messages: Belongs to the ZC3H12 family.

9031:CTSV
gene id: 9031:CTSV
uniprot id: F1NYJ1
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:CYP2R1
gene id: 9031:CYP2R1
uniprot id: F1NB14
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:NCALD
gene id: 9031:NCALD
uniprot id: P62758
names: Function
names: Similarity
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).

9031:SLC46A3
gene id: 9031:SLC46A3
uniprot id: F1P383
uniprot id: Q5F4B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. SLC46A family.
messages: Membrane

9031:SLC23A2
gene id: 9031:SLC23A2
uniprot id: B9VMA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9031:DDX3X
gene id: 9031:DDX3X
uniprot id: Q5F491
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:RPN2
gene id: 9031:RPN2
uniprot id: Q5ZM80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9031:ZIC3
gene id: 9031:ZIC3
uniprot id: A0A1D5PRL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9031:AP4B1
gene id: 9031:AP4B1
uniprot id: Q5ZJB3
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9031:CENPP
gene id: 9031:CENPP
uniprot id: Q1T7B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-P/CTF19 family.
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP.
messages: Nucleus
messages: centromere

9031:PLN
gene id: 9031:PLN
uniprot id: P26677
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Heart.
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Phosphorylated in response to beta-adrenergic stimulation. Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake (By similarity).
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity).
messages: Sarcoplasmic reticulum membrane

9031:LOC770890
gene id: 9031:LOC770890
uniprot id: A0A1L1RQ52
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9031:ENDOUL
gene id: 9031:ENDOUL
uniprot id: A0A1D5NXH1
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

9031:SCARF2
gene id: 9031:SCARF2
uniprot id: A0A1D5NYT1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:DLST
gene id: 9031:DLST
uniprot id: F1NQH8
uniprot id: Q5F326
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9031:ALDH8A1
gene id: 9031:ALDH8A1
uniprot id: F1P4K4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9031:HPRT1
gene id: 9031:HPRT1
uniprot id: Q9W719
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.
messages: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
messages: Cytoplasm
messages: Homotetramer.

9031:GPR20
gene id: 9031:GPR20
uniprot id: A0A1D5PS37
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:LYG2
gene id: 9031:LYG2
uniprot id: F1P5H6
uniprot id: P27042
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 23 family.
messages: Granulocyte compartment of myelomonocytic cells.
messages: Secreted
messages: Shows preference for N-acetylmuramic acid residues that are substituted with a peptide moiety. It acts only as a glycanohydrolase.

9031:EFNB2
gene id: 9031:EFNB2
uniprot id: Q9PUJ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:FABP7
gene id: 9031:FABP7
uniprot id: Q05423
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: Highest expression in early stages of retinal development with a 50-100 fold decrease from day 3 to day 19 of retina maturation.

9031:SQLE
gene id: 9031:SQLE
uniprot id: A0A1D5NWK3
uniprot id: Q5ZKQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

9031:OPRK1
gene id: 9031:OPRK1
uniprot id: E1C0V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with SLC9A3R1. Interacts with GABARAPL1.
messages: Membrane

9031:SLC35A3
gene id: 9031:SLC35A3
uniprot id: F1NZW9
uniprot id: Q5ZJS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9031:SDC2
gene id: 9031:SDC2
uniprot id: Q8JIX9
uniprot id: Q8JIY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9031:MYO5A
gene id: 9031:MYO5A
uniprot id: Q02440
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Golgi apparatus membrane
messages: May be a homodimer, which associates with multiple calmodulin or myosin light chains.
messages: Neuronal and non-neuronal cells of the brain.
messages: Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (By similarity).

9031:BAIAP2
gene id: 9031:BAIAP2
uniprot id: A0A1D5P0L1
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9031:ORAI1
gene id: 9031:ORAI1
uniprot id: Q5ZL05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores.
messages: Cell membrane

9031:LOC100857710
gene id: 9031:LOC100857710
uniprot id: A0A1D5PJ64
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:VSX1
gene id: 9031:VSX1
uniprot id: Q9IAL2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At stage 12, expressed throughout the invaginating optic vesicles and a subset of cells in the ventral spinal cord, presumably interneuron precursors. At stage 14, when the optic cup forms, expression is restricted to a subset of retinoblasts. At stage 15, expression along the ventral spinal and hindbrain intensifies and persists beyond stage 20.
messages: Belongs to the paired homeobox family.
messages: Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity).
messages: Nucleus
messages: Restricted to bipolar cells of the retina and spinal cord.

9031:CALCRL
gene id: 9031:CALCRL
uniprot id: C5HV42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP). Receptor specificity may be modulated by accessory proteins. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9031:PHAF1
gene id: 9031:PHAF1
uniprot id: Q5ZKM4
names: Similarity
messages: Belongs to the PHAF1 family.

9031:OAF
gene id: 9031:OAF
uniprot id: Q71SY6
names: Similarity
messages: Belongs to the OAF family.

9031:MOCS3
gene id: 9031:MOCS3
uniprot id: E1C3M4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9031:YY2
gene id: 9031:YY2
uniprot id: Q5ZMN5
names: Similarity
messages: Belongs to the YY transcription factor family.

9031:CEBPB
gene id: 9031:CEBPB
uniprot id: Q05826
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Binds DNA as a dimer. Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005).
messages: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:8467792). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications.
messages: Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates the transcription of these genes.
messages: Methylated. Methylation at Arg-3 by CARM1 and at Lys-39 by EHMT2, inhibit transactivation activity. Methylation is probably inhibited by phosphorylation at Thr-220.
messages: Nucleus
messages: Specifically expressed in myelomoncytic cells.

9031:DIO1
gene id: 9031:DIO1
uniprot id: O42411
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iodothyronine deiodinase family.
messages: Endoplasmic reticulum membrane
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).

9031:TP53I11
gene id: 9031:TP53I11
uniprot id: F1NS21
names: Subcellular Location Annotation
messages: Membrane

9031:DNAJA4
gene id: 9031:DNAJA4
uniprot id: A0A1D5NYA8
names: Subcellular Location Annotation
messages: Membrane

9031:SLC30A5
gene id: 9031:SLC30A5
uniprot id: Q5ZLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: COPII-coated vesicle membrane
messages: Golgi stack membrane
messages: Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.
messages: Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15525635). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635).
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9031:RPL17
gene id: 9031:RPL17
uniprot id: A0A1D5PR40
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9031:PLXNA1
gene id: 9031:PLXNA1
uniprot id: F1N804
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:ARPC2
gene id: 9031:ARPC2
uniprot id: F1P1K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

9031:MRPL47
gene id: 9031:MRPL47
uniprot id: A0A1L1RWY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

9031:TNFSF13B
gene id: 9031:TNFSF13B
uniprot id: Q8JHJ4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9031:PIM3
gene id: 9031:PIM3
uniprot id: E1BY69
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9031:HSD3B1
gene id: 9031:HSD3B1
uniprot id: Q91997
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9031:SPHKAP
gene id: 9031:SPHKAP
uniprot id: A0A1L1RRJ9
uniprot id: F1NAV5
names: Similarity
messages: Belongs to the AKAP110 family.

9031:MATN3
gene id: 9031:MATN3
uniprot id: O42401
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Can form homooligomers (monomers, dimers, trimers and tetramers) and heterooligomers with matrilin-1.
messages: Expression is restricted to cartilaginous tissues.
messages: Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
messages: Secreted

9031:LOC121106448
gene id: 9031:LOC121106448
uniprot id: F1NEZ4
names: Similarity
messages: Belongs to the SLITRK family.

9031:PDE8B
gene id: 9031:PDE8B
uniprot id: F1P2B9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:NPM1
gene id: 9031:NPM1
uniprot id: P16039
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity).
messages: Belongs to the nucleoplasmin family.
messages: Cytoplasm
messages: Decamer formed by two pentameric rings associated in a head-to-head fashion.
messages: Phosphorylated.
messages: nucleolus
messages: nucleoplasm

9031:PTPRA
gene id: 9031:PTPRA
uniprot id: F1NPE8
uniprot id: Q91969
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:C4A
gene id: 9031:C4A
uniprot id: A0A1D5PU94
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse
messages: axon
messages: dendrite

9031:CA3A
gene id: 9031:CA3A
uniprot id: A0A1D5NTS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

9031:MAGI3
gene id: 9031:MAGI3
uniprot id: A0A3Q2U7B8
uniprot id: Q5F488
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes.
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

9031:GPX8
gene id: 9031:GPX8
uniprot id: R4GGB2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9031:HMOX1
gene id: 9031:HMOX1
uniprot id: P14791
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: A soluble form arises by proteolytic removal of the membrane anchor.
messages: Belongs to the heme oxygenase family.
messages: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:1996964, PubMed:2158889). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity).
messages: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
messages: Endoplasmic reticulum membrane
messages: Inhibited by metalloporphyrins in the following order of decreasing potency: tin mesoporphyrin > tin protoporphyrin > zinc protoporphyrin > manganese protoporphyrin > cobalt protoporphyrin.

9031:THOC2
gene id: 9031:THOC2
uniprot id: A0A3S5ZP33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

9031:ZC3H14
gene id: 9031:ZC3H14
uniprot id: Q5F3Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZC3H14 family.
messages: May bind to RNA.
messages: Nucleus speckle

9031:BAP1
gene id: 9031:BAP1
uniprot id: Q5F3N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family. BAP1 subfamily.
messages: Component of the PR-DUB complex.
messages: Cytoplasm
messages: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).
messages: Nucleus

9031:CYP2W2
gene id: 9031:CYP2W2
uniprot id: A0A1L1RLF0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:MIXL1
gene id: 9031:MIXL1
uniprot id: O73592
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Expressed early in embryogenis in a sickle-shaped area in the posterior zone of the blastoderm. With the beginning of gastrulation, it is found in the primitive streak primordium, then in the young and medium-sized streak, however not in the mesoderm after its emergence. In the fully-extended streak, it is restricted to its middle, i.e. the prospective ventral mesoderm. It is then undetectable by in later stages.
messages: Nucleus
messages: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood (By similarity).

9031:FAM199X
gene id: 9031:FAM199X
uniprot id: F1NN36
names: Similarity
messages: Belongs to the FAM199 family.

9031:ACADL
gene id: 9031:ACADL
uniprot id: Q5ZJ93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9031:PTPN6
gene id: 9031:PTPN6
uniprot id: Q5F3I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9031:HDAC1
gene id: 9031:HDAC1
uniprot id: P56517
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Also functions as deacetylase for non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (By similarity).
messages: Nucleus

9031:SMYD2
gene id: 9031:SMYD2
uniprot id: A0A0A0MQ47
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
messages: cytosol

9031:PLA2G4EL2
gene id: 9031:PLA2G4EL2
uniprot id: R4GHN4
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9031:BCL2L10
gene id: 9031:BCL2L10
uniprot id: Q90ZN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Bcl-2 family.
messages: Cell membrane
messages: Expressed preferentially in heart, skeletal muscle, retina, optical tectum and bursa of Fabricius.
messages: Interacts with BAX.
messages: Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX.

9031:KLHL22
gene id: 9031:KLHL22
uniprot id: E1BS99
names: Subcellular Location Annotation
messages: Lysosome
messages: Nucleus
messages: centrosome
messages: cytosol
messages: spindle

9031:LOC107052811
gene id: 9031:LOC107052811
uniprot id: A0A1D5P6V7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:AVPR2
gene id: 9031:AVPR2
uniprot id: Q9PTN7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:NPY2R
gene id: 9031:NPY2R
uniprot id: Q9DDN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for neuropeptide Y and peptide YY.

9031:MRPS18A
gene id: 9031:MRPS18A
uniprot id: A0A1D5NZU8
names: Subcellular Location Annotation
messages: Mitochondrion

9031:PDE7B
gene id: 9031:PDE7B
uniprot id: A0A3Q2TZX9
uniprot id: A0A3Q2UQ10
uniprot id: F1NVY7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:PSMA6
gene id: 9031:PSMA6
uniprot id: F1NEQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9031:SVOPL
gene id: 9031:SVOPL
uniprot id: E1BVZ2
names: Subcellular Location Annotation
messages: Membrane

9031:NOL8
gene id: 9031:NOL8
uniprot id: E1BT63
names: Subcellular Location Annotation
messages: nucleolus

9031:CSNK1E
gene id: 9031:CSNK1E
uniprot id: Q5ZLL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm (By similarity).
messages: Cytoplasm
messages: Monomer (By similarity). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1E, and the PER proteins (By similarity).

9031:ACTR1A
gene id: 9031:ACTR1A
uniprot id: Q5ZM58
names: Similarity
messages: Belongs to the actin family.

9031:SLC2A11L4
gene id: 9031:SLC2A11L4
uniprot id: F1P492
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:FMNL2
gene id: 9031:FMNL2
uniprot id: A0A1D5P5Y7
names: Similarity
messages: Belongs to the formin homology family.

9031:ACTB
gene id: 9031:ACTB
uniprot id: P60706
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylation at His-73 by SETD3 (PubMed:30626964). Methylation stabilizes actin filaments (PubMed:11955010).
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (By similarity). Each actin can bind to 4 others (By similarity).
messages: cytoskeleton

9031:HABP4
gene id: 9031:HABP4
uniprot id: Q9I9R0
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo.
messages: Associates with polysomes.
messages: Cajal body
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation.
messages: Stress granule
messages: The C-terminal region is necessary for nucleus and cytoplasmic localization. The N-terminal region is necessary for nucleus and nuclear bodies localization.
messages: gem
messages: nuclear body
messages: nucleolus
messages: sarcoplasm

9031:NCS1
gene id: 9031:NCS1
uniprot id: P62167
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the recoverin family.
messages: Binds 3 calcium ions via the second, third and fourth EF-hand.
messages: Cell membrane
messages: Cytoplasm
messages: Found in embryos from 3 dpc to adult stages.
messages: Golgi apparatus
messages: Interacts with KCND2.
messages: Membrane
messages: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin.
messages: Post-mitotic neurons in the central and peripheral nervous system.
messages: Postsynaptic density
messages: perinuclear region

9031:ZC3H15
gene id: 9031:ZC3H15
uniprot id: A0A1D5PMI7
uniprot id: Q5H7N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZC3H15/TMA46 family.
messages: Cytoplasm
messages: Interacts with DRG1.
messages: Nucleus
messages: Protects DRG1 from proteolytic degradation.

9031:SENP7
gene id: 9031:SENP7
uniprot id: A0A1L1RZS3
names: Similarity
messages: Belongs to the peptidase C48 family.

9031:ERLIN1
gene id: 9031:ERLIN1
uniprot id: F1NJ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Membrane

9031:HAPLN3
gene id: 9031:HAPLN3
uniprot id: E1BUN0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:C5
gene id: 9031:C5
uniprot id: E1BRS7
names: Subcellular Location Annotation
messages: Secreted

9031:LOC417291
gene id: 9031:LOC417291
uniprot id: A0A1D5PKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SERPINE2
gene id: 9031:SERPINE2
uniprot id: A0A1D5PLJ1
uniprot id: E1BWU2
names: Similarity
messages: Belongs to the serpin family.

9031:MYL3
gene id: 9031:MYL3
uniprot id: P02606
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.

9031:BID
gene id: 9031:BID
uniprot id: A0A140T8G9
uniprot id: A0A3Q2U873
uniprot id: Q8JGM8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2.
messages: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.
messages: Induces caspases and apoptosis. Counters the protective effect of BCL2.
messages: Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity).
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
messages: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:CASP6
gene id: 9031:CASP6
uniprot id: A0A1D5PPP7
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C14A family.
messages: Cysteine protease that plays essential roles in programmed cell death, development and innate immunity (PubMed:11953316). Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein lamin-A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:11953316). Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution (PubMed:11953316). Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity. PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis (By similarity).
messages: Cytoplasm
messages: During activation, the N-terminal prodomain is removed by cleavage (By similarity). Concomitantly, double cleavage gives rise to a large 18-kDa and a small 11-kDa subunit (By similarity). The two large and two small subunits then assemble to form the active CASP6 complex (By similarity). Intramolecular cleavage at Asp-191 is a prerequisite for CASP6 self-activation (By similarity).
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit.
messages: Nucleus
messages: The N-terminal disordered prodomain is required to prevent self-activation.
messages: The Tri-arginine exosite is required to recruit substrates for hydrolysis.
messages: Undergoes helix-strand structural transitions upon substrate-binding: the 130's region interconverts between an inactive helical state and the canonically active strand state. Other caspases rest constitutively in the strand conformation before and after substrate-binding.
messages: Widely expressed.

9031:DNAJB12
gene id: 9031:DNAJB12
uniprot id: A0A1D5P1X0
uniprot id: Q5F3M7
names: Subcellular Location Annotation
messages: Membrane

9031:TFEB
gene id: 9031:TFEB
uniprot id: Q5ZM43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9031:LMNA
gene id: 9031:LMNA
uniprot id: P13648
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
messages: Nucleus

9031:CLDN11
gene id: 9031:CLDN11
uniprot id: E1BR31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:DHODH
gene id: 9031:DHODH
uniprot id: Q5ZHY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9031:HIST1H110
gene id: 9031:HIST1H110
uniprot id: P08286
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

9031:CNP
gene id: 9031:CNP
uniprot id: O57389
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

9031:PPIF
gene id: 9031:PPIF
uniprot id: Q5ZMJ0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9031:HDAC8
gene id: 9031:HDAC8
uniprot id: F1NFY6
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.

9031:YIPF7
gene id: 9031:YIPF7
uniprot id: E1C864
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9031:CCDC85A
gene id: 9031:CCDC85A
uniprot id: A0A1L1RJ65
uniprot id: A0A1L1RR59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9031:MFSD8
gene id: 9031:MFSD8
uniprot id: F1NBR6
names: Subcellular Location Annotation
messages: Membrane

9031:DRC7
gene id: 9031:DRC7
uniprot id: A0A1D5PB27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

9031:LY86
gene id: 9031:LY86
uniprot id: Q90890
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By myb.
messages: Detected in the macrophage-like 10.4 cells.
messages: M-shaped tetramer of two CD180-LY86 heterodimers.
messages: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity).
messages: extracellular space

9031:RAB14
gene id: 9031:RAB14
uniprot id: Q5ZKU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity).
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

9031:ANAPC2
gene id: 9031:ANAPC2
uniprot id: F1NLT0
names: Similarity
messages: Belongs to the cullin family.

9031:DCTN1
gene id: 9031:DCTN1
uniprot id: A0A1D5PEZ3
uniprot id: P35458
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the dynactin 150 kDa subunit family.
messages: Binds to microtubules and to cytoplasmic dynein. Binds preferentially to tyrosinated microtubules than to detyrosinated microtubules.
messages: Cytoplasm
messages: Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Plays a role in metaphase spindle orientation.
messages: Ubiquitously expressed.
messages: cell cortex
messages: centriole
messages: centrosome
messages: cytoskeleton
messages: spindle

9031:NPL
gene id: 9031:NPL
uniprot id: Q5ZKD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
messages: Cytoplasm
messages: Homotetramer.

9031:COA7
gene id: 9031:COA7
uniprot id: A0A1D5PGZ5
uniprot id: A0A1D5PPW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space

9031:ENY2
gene id: 9031:ENY2
uniprot id: A0A1D5PYW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

9031:LBX1
gene id: 9031:LBX1
uniprot id: B0FMT5
names: Subcellular Location Annotation
messages: Nucleus

9031:ART7B
gene id: 9031:ART7B
uniprot id: A9NJ59
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:PTPRT
gene id: 9031:PTPRT
uniprot id: A0A3Q2TX63
uniprot id: A0A3Q2TXT9
uniprot id: A0A3Q2U2J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

9031:TBCCD1
gene id: 9031:TBCCD1
uniprot id: Q5ZKT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: May play a role in the regulation of centrosome and Golgi apparatus positioning.
messages: centrosome
messages: spindle pole

9031:TGFBR2
gene id: 9031:TGFBR2
uniprot id: A0A1I7Q417
uniprot id: Q90999
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Detected at low levels in embryonic heart, brain and lung. Detected at high levels in hatchling heart and lung.
messages: Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer.
messages: Membrane
messages: Membrane raft
messages: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).

9031:RPL22
gene id: 9031:RPL22
uniprot id: Q98TF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9031:SLC44A1
gene id: 9031:SLC44A1
uniprot id: A0A3Q2U280
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9031:NLN
gene id: 9031:NLN
uniprot id: E1C0D8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9031:GATA4
gene id: 9031:GATA4
uniprot id: E1C9C6
uniprot id: P43691
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: More abundant in heart, with lower levels detected in ovary and small intestine.
messages: Nucleus
messages: Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity).

9031:ANAPC15
gene id: 9031:ANAPC15
uniprot id: A0A1D5PUJ5
names: Similarity
messages: Belongs to the APC15 family.

9031:LSM14A
gene id: 9031:LSM14A
uniprot id: A0A3Q3AZ50
uniprot id: Q5ZL27
names: Similarity
messages: Belongs to the LSM14 family.

9031:CCLI5
gene id: 9031:CCLI5
uniprot id: A0A3S5ZPQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:ZEB1
gene id: 9031:ZEB1
uniprot id: A0A2D3HKK9
uniprot id: P36197
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter (By similarity). Binds to delta 1-crystallin enhancer core and represses lens-specific transcription. It binds as well many other non-lens specific DNA sequences.
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
messages: Expression is developmentally regulated with high expression in mesoderm, nervous system and lens.
messages: Expression starts after gastrulation, when organogenesis has just begun.
messages: May interact with CTBP1.
messages: Nucleus

9031:FAM19A2
gene id: 9031:FAM19A2
uniprot id: F1NFR1
names: Similarity
messages: Belongs to the TAFA family.

9031:MYO1F
gene id: 9031:MYO1F
uniprot id: Q90748
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:CNPPD1
gene id: 9031:CNPPD1
uniprot id: Q5ZJH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNPPD1 family.
messages: Membrane

9031:CDKN1A
gene id: 9031:CDKN1A
uniprot id: M9TKU1
uniprot id: Q8AYE7
names: Similarity
messages: Belongs to the CDI family.

9031:RAB2A
gene id: 9031:RAB2A
uniprot id: Q90965
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Interacts with PRKCI. Interacts with TRIP11 (By similarity). Interacts (in GTP-bound form) with GARIN1B (By similarity).
messages: Melanosome
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology.
messages: acrosome

9031:DSG2
gene id: 9031:DSG2
uniprot id: F1NJD5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9031:HOXB2
gene id: 9031:HOXB2
uniprot id: R4GLI3
names: Subcellular Location Annotation
messages: Nucleus

9031:CDS1
gene id: 9031:CDS1
uniprot id: F1NYE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9031:NAA35
gene id: 9031:NAA35
uniprot id: F1NYK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9031:RGS4
gene id: 9031:RGS4
uniprot id: A0A3Q2U3K2
uniprot id: Q7SZC6
names: Function
names: PTM
names: Tissue Specificity
messages: Expressed in the developing nervous system.
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By similarity).
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
messages: Palmitoylated on Cys-2 and/or Cys-12.
messages: Phosphorylated by cyclic GMP-dependent protein kinase.

9031:PRDX1
gene id: 9031:PRDX1
uniprot id: P0CB50
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer (By similarity). Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (PubMed:19766572). Interacts with SESN1 and SESN2 (By similarity).
messages: Reduced levels of PRDX1 by RNAi cause the loss of motor neurons but did not alter the number of motor neuron progenitors or the dorsal-ventral pattering of spinal progenitors, and did not compromise motor neuron survival.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (PubMed:19766572).

9031:PPP1R12A
gene id: 9031:PPP1R12A
uniprot id: A0A1D5NU36
uniprot id: Q90623
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Detected in brain, lung, aorta, heart, gizzard, stomach, oviduct, spleen, kidney and small intestine.
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits (By similarity). PPP1R12A mediates binding to myosin.
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: Phosphorylated by CIT (Rho-associated kinase) and by ROCK2 on serine and threonine residues. Phosphorylation at Thr-695 leads to inhibition of myosin phosphatase activity. Phosphorylation at Thr-850 abolishes myosin binding. May be phosphorylated at Thr-695 by DMPK; may inhibit the myosin phosphatase activity.
messages: Regulates myosin phosphatase activity.
messages: stress fiber

9031:IRF2
gene id: 9031:IRF2
uniprot id: Q98925
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IRF family.
messages: Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity.
messages: Nucleus
messages: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation (By similarity).

9031:ECHDC1
gene id: 9031:ECHDC1
uniprot id: A0A1D5PY85
uniprot id: H9L0N9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9031:STX10
gene id: 9031:STX10
uniprot id: Q5ZL19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane
messages: Recycling endosome membrane
messages: SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.
messages: trans-Golgi network membrane

9031:TSPO
gene id: 9031:TSPO
uniprot id: F1NZA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9031:CYBB
gene id: 9031:CYBB
uniprot id: A7E3K8
names: Subcellular Location Annotation
messages: Membrane

9031:GPR35
gene id: 9031:GPR35
uniprot id: A0A1D5PER1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:OPN5
gene id: 9031:OPN5
uniprot id: B3XZF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:BCO2
gene id: 9031:BCO2
uniprot id: E1C8E0
uniprot id: R4GL86
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

9031:PPL
gene id: 9031:PPL
uniprot id: F1NV96
names: Subcellular Location Annotation
messages: cytoskeleton

9031:SUSD3
gene id: 9031:SUSD3
uniprot id: R4GJ53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PLG
gene id: 9031:PLG
uniprot id: F1NWX6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

9031:MYOG
gene id: 9031:MYOG
uniprot id: C4P6Q3
uniprot id: P17920
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).
messages: Homodimer and heterodimer. Efficient DNA binding requires dimerization with another bHLH protein (By similarity).
messages: Nucleus

9031:DPAGT1
gene id: 9031:DPAGT1
uniprot id: A0A1D5PQ50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:SFT2D1
gene id: 9031:SFT2D1
uniprot id: F1NPE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9031:CAMSAP2
gene id: 9031:CAMSAP2
uniprot id: A0A1D5PU82
uniprot id: E1BY04
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

9031:SETD1A
gene id: 9031:SETD1A
uniprot id: Q5F3P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
messages: Nucleus speckle

9031:DOK5
gene id: 9031:DOK5
uniprot id: E1C0X0
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9031:ST8SIA4
gene id: 9031:ST8SIA4
uniprot id: O42399
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:ANKHD1
gene id: 9031:ANKHD1
uniprot id: E1BXT7
names: Subcellular Location Annotation
messages: Cytoplasm

9031:DTYMK
gene id: 9031:DTYMK
uniprot id: A0A1D5PKC2
names: Similarity
messages: Belongs to the thymidylate kinase family.

9031:ALDH5A1
gene id: 9031:ALDH5A1
uniprot id: A0A1D5PFY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

9031:SGK2
gene id: 9031:SGK2
uniprot id: E1BZK5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:CAPZA2
gene id: 9031:CAPZA2
uniprot id: A0M8U0
uniprot id: P28497
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CapZ may mediate the attachment of the barbed ends of actin filaments to the Z-line.
messages: Heterodimer of an alpha and a beta subunit.
messages: Heterodimer of an alpha and a beta subunit. Component of the WASH complex (By similarity).
messages: Present in all tissues examined.
messages: Z line

9031:HTR1F
gene id: 9031:HTR1F
uniprot id: E1C3Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

9031:CLN5
gene id: 9031:CLN5
uniprot id: F1NZF1
names: Similarity
messages: Belongs to the CLN5 family.

9031:IWS1
gene id: 9031:IWS1
uniprot id: E1BRQ9
names: Subcellular Location Annotation
messages: Nucleus

9031:OSTC
gene id: 9031:OSTC
uniprot id: Q5ZJR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: Specific component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex.

9031:SLC34A2
gene id: 9031:SLC34A2
uniprot id: Q6TQF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

9031:PKP4
gene id: 9031:PKP4
uniprot id: A0A3Q2U9L2
uniprot id: Q5ZK79
names: Similarity
messages: Belongs to the beta-catenin family.

9031:BIRC2
gene id: 9031:BIRC2
uniprot id: A0A140T8H6
uniprot id: Q90660
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apoptotic suppressor.
messages: Belongs to the IAP family.
messages: Cells of the T-lymphocyte lineage. Found in both cortical and medullary cells of the thymus. Expressed at relatively high levels also in spleen, bursa, intestine and lung and at very low levels in testis, brain and skeletal muscle.
messages: Cytoplasm
messages: High levels are induced within 4-8 hours of T-cell activation in spleen and thymus.
messages: Nucleus
messages: The ring finger is important for its antiapoptotic effect.

9031:SLC7A13
gene id: 9031:SLC7A13
uniprot id: A0A1D5PVL1
names: Subcellular Location Annotation
messages: Membrane

9031:SLC4A3
gene id: 9031:SLC4A3
uniprot id: E1C314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

9031:NOC2L
gene id: 9031:NOC2L
uniprot id: Q5ZJT9
names: Similarity
messages: Belongs to the NOC2 family.

9031:DPT
gene id: 9031:DPT
uniprot id: A0A1D5NVS3
names: Similarity
messages: Belongs to the dermatopontin family.

9031:FBXO34
gene id: 9031:FBXO34
uniprot id: A0A1D5P447
uniprot id: Q5ZI71
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9031:SEC24D
gene id: 9031:SEC24D
uniprot id: E1BSP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9031:PRPF4B
gene id: 9031:PRPF4B
uniprot id: F1P4D7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

9031:PPP1CC
gene id: 9031:PPP1CC
uniprot id: Q5ZL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Cytoplasm
messages: Midbody

9031:NTMT1
gene id: 9031:NTMT1
uniprot id: H9L0S2
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9031:KCNG1
gene id: 9031:KCNG1
uniprot id: E1C3M8
names: Subcellular Location Annotation
messages: Membrane

9031:QSOX2
gene id: 9031:QSOX2
uniprot id: F1P458
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

9031:AvBD13
gene id: 9031:AvBD13
uniprot id: Q6IV18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Expressed in the liver, gall bladder, kidney, small intestine, spleen, testis, ovary and male and female reproductive tracts. Not detected in the ovarian stroma and the theca and granulosa layers of the ovarian follicle.
messages: Has bactericidal activity.
messages: Has bactericidal activity. Potent activity against E.coli, L.monocytogenes, S.typhimurium and S.pyogenes but mot against S.aureus.
messages: Secreted

9031:TRNAU1AP
gene id: 9031:TRNAU1AP
uniprot id: E1BZH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Nucleus

9031:GKAP1
gene id: 9031:GKAP1
uniprot id: A0A3Q2UNC5
uniprot id: A0A3Q3AH83
names: Similarity
messages: Belongs to the GKAP1 family.

9031:COPB2
gene id: 9031:COPB2
uniprot id: A0A1L1RUT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

9031:CHGB
gene id: 9031:CHGB
uniprot id: A0A1L1S0I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9031:LOC107049158
gene id: 9031:LOC107049158
uniprot id: A0A3Q2UNR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:LAMB4
gene id: 9031:LAMB4
uniprot id: F1NUQ6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9031:PSMA1
gene id: 9031:PSMA1
uniprot id: O42265
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

9031:EMP2
gene id: 9031:EMP2
uniprot id: A0A3Q2TX99
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9031:EPB41L5
gene id: 9031:EPB41L5
uniprot id: A0A3Q2UIC0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.

9031:RNF2
gene id: 9031:RNF2
uniprot id: A0A1D5P1F4
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

9031:CRABP1
gene id: 9031:CRABP1
uniprot id: B0FLN8
uniprot id: P40220
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

9031:SBNO2
gene id: 9031:SBNO2
uniprot id: A0A1D5NY24
uniprot id: A0A1D5PRM4
names: Similarity
messages: Belongs to the SBNO family.

9031:FAM168B
gene id: 9031:FAM168B
uniprot id: F1NVB8
names: Similarity
messages: Belongs to the FAM168 family.

9031:PAQR7
gene id: 9031:PAQR7
uniprot id: C6KGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9031:OPRD1
gene id: 9031:OPRD1
uniprot id: A0A1D5P5H3
uniprot id: A0A2Z2CIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:CXCR1
gene id: 9031:CXCR1
uniprot id: Q334G8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:SORCS3
gene id: 9031:SORCS3
uniprot id: F1P3Q2
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9031:NPFFR2
gene id: 9031:NPFFR2
uniprot id: F1NVD9
uniprot id: Q4AE91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9031:HAUS1
gene id: 9031:HAUS1
uniprot id: Q5ZJG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

9031:UBQLN1
gene id: 9031:UBQLN1
uniprot id: A0A3Q3AGG5
uniprot id: E1C477
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

9031:BICD2
gene id: 9031:BICD2
uniprot id: A0A3Q2U5E5
uniprot id: E1C2N3
names: Similarity
messages: Belongs to the BicD family.

9031:USP2
gene id: 9031:USP2
uniprot id: Q9YHZ2
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:EVA1A
gene id: 9031:EVA1A
uniprot id: R4GI08
names: Similarity
messages: Belongs to the EVA1 family.

9031:SPIA5
gene id: 9031:SPIA5
uniprot id: E1C206
names: Similarity
messages: Belongs to the serpin family.

9031:TMEM50A
gene id: 9031:TMEM50A
uniprot id: A0A1D5P292
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9031:COX10
gene id: 9031:COX10
uniprot id: Q5ZJY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9031:PTGFR
gene id: 9031:PTGFR
uniprot id: Q1PA18
uniprot id: Q3HS34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:LGR4
gene id: 9031:LGR4
uniprot id: A0A1D5PB24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:PLPPR5
gene id: 9031:PLPPR5
uniprot id: A0A3Q3APE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9031:ATP6V0E1
gene id: 9031:ATP6V0E1
uniprot id: Q5ZJC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9031:TMED10
gene id: 9031:TMED10
uniprot id: Q5ZIR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:USP22
gene id: 9031:USP22
uniprot id: A0A1D5PTS9
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:RFC2
gene id: 9031:RFC2
uniprot id: A0A1D5PYS3
uniprot id: P53033
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA (By similarity).
messages: Nucleus
messages: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).

9031:FIP1L1
gene id: 9031:FIP1L1
uniprot id: A0A1D5PZ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9031:UQCC1
gene id: 9031:UQCC1
uniprot id: Q5ZIZ3
names: Similarity
messages: Belongs to the CBP3 family.

9031:ITGB6
gene id: 9031:ITGB6
uniprot id: E1C6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9031:TOP1
gene id: 9031:TOP1
uniprot id: P79994
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9031:HIST2H3D
gene id: 9031:HIST2H3D
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:WT1
gene id: 9031:WT1
uniprot id: Q9I8A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9031:DDAH1
gene id: 9031:DDAH1
uniprot id: Q7ZTS9
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9031:FANCM
gene id: 9031:FANCM
uniprot id: A0A1D5PRR9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
messages: Component of the Fanconi anemia (FA) core complex. The FA core complex associates with Bloom syndrome (BLM) complex. This supercomplex between FA and BLM complexes has been called BRAFT.
messages: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116434, PubMed:19465393). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork (By similarity). This activity is strongly stimulated in the presence of CENPS and CENPX (By similarity). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (By similarity). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (By similarity).
messages: Nucleus
messages: Phosphorylated; hyperphosphorylated in response to genotoxic stress.

9031:DYL1
gene id: 9031:DYL1
uniprot id: Q5F412
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9031:AMDHD1
gene id: 9031:AMDHD1
uniprot id: F1P298
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

9031:UMPS
gene id: 9031:UMPS
uniprot id: Q5ZMR2
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9031:SNRPF
gene id: 9031:SNRPF
uniprot id: A0A1L1RSB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9031:SPPL2A
gene id: 9031:SPPL2A
uniprot id: Q5F3M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9031:PIK3AP1
gene id: 9031:PIK3AP1
uniprot id: Q9DDT2
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Constitutively phosphorylated (By similarity). Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation.
messages: Cytoplasm
messages: Homooligomer (By similarity). Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase.
messages: It is unsure whether this isoform is produced by alternative splicing or alternative initiation.
messages: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
messages: The DBB domain is required for dimerization.

9031:AK5
gene id: 9031:AK5
uniprot id: A0A1D5PK46
names: Similarity
messages: Belongs to the adenylate kinase family.

9031:COLGALT1
gene id: 9031:COLGALT1
uniprot id: A0A1D5P6H9
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9031:HISTH2A4L1
gene id: 9031:HISTH2A4L1
uniprot id: P02263
uniprot id: Q92069
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AK119Ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties, leading to the recruitment of repair proteins to sites of DNA damage. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:DNER
gene id: 9031:DNER
uniprot id: F1N9F4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:EFHC1
gene id: 9031:EFHC1
uniprot id: F6U0Q8
names: Subcellular Location Annotation
messages: cilium axoneme

9031:F3
gene id: 9031:F3
uniprot id: F1NGT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

9031:GSL
gene id: 9031:GSL
uniprot id: F1P0D2
names: Similarity
messages: Belongs to the glutamine synthetase family.

9031:GJA5
gene id: 9031:GJA5
uniprot id: A0A1D5PJ30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:URM1
gene id: 9031:URM1
uniprot id: Q5ZJU4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3 homolog.
messages: Cytoplasm

9031:AARSD1
gene id: 9031:AARSD1
uniprot id: F1NC49
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9031:MDH1B
gene id: 9031:MDH1B
uniprot id: E1BQM3
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

9031:CCNA1
gene id: 9031:CCNA1
uniprot id: F1P4N0
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9031:MAPRE1
gene id: 9031:MAPRE1
uniprot id: Q5ZLC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: Golgi apparatus
messages: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9031:TNS4
gene id: 9031:TNS4
uniprot id: R4GJC5
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

9031:AADACL3B
gene id: 9031:AADACL3B
uniprot id: A0A3Q2U6E5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9031:NCK1
gene id: 9031:NCK1
uniprot id: Q5ZK48
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9031:ATP5S
gene id: 9031:ATP5S
uniprot id: F1NBU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion inner membrane

9031:POSTN
gene id: 9031:POSTN
uniprot id: A0A3Q2U321
uniprot id: A0A3Q2UBV6
uniprot id: A0A3Q2UC30
uniprot id: F1N8W3
uniprot id: F1P4N9
uniprot id: Q6DMS3
names: Subcellular Location Annotation
messages: extracellular matrix

9031:SLITRK6
gene id: 9031:SLITRK6
uniprot id: A0A1L1RNJ0
names: Similarity
messages: Belongs to the SLITRK family.

9031:SPECC1L
gene id: 9031:SPECC1L
uniprot id: Q2KN97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

9031:HGF
gene id: 9031:HGF
uniprot id: A0A1D5PAR6
uniprot id: A0A3Q2U5D1
uniprot id: Q788Q2
uniprot id: Q90978
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

9031:LOC417013
gene id: 9031:LOC417013
uniprot id: F1N9B4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9031:ATP2A3
gene id: 9031:ATP2A3
uniprot id: Q9YGL9
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Down-regulated by 1,25-dihydroxyvitamin D3.
messages: Endoplasmic reticulum membrane
messages: Found in spleen, lung, intestine and brain.
messages: Inhibited by sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity).
messages: Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity).
messages: Sarcoplasmic reticulum membrane
messages: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

9031:MCM5
gene id: 9031:MCM5
uniprot id: Q5ZKL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

9031:HIST1H3A
gene id: 9031:HIST1H3A
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:RDH5
gene id: 9031:RDH5
uniprot id: Q9DGM0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:ETV3
gene id: 9031:ETV3
uniprot id: H9KYV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

9031:PHOSPHO2
gene id: 9031:PHOSPHO2
uniprot id: E1C2Z3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9031:GRIA4
gene id: 9031:GRIA4
uniprot id: Q90858
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:CFDP1
gene id: 9031:CFDP1
uniprot id: Q75QI0
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

9031:SIAH2
gene id: 9031:SIAH2
uniprot id: E1C3Q9
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9031:GLIS3
gene id: 9031:GLIS3
uniprot id: E1C1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9031:TUBAL3
gene id: 9031:TUBAL3
uniprot id: F1P5B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:CACNB2
gene id: 9031:CACNB2
uniprot id: A0A1D5P3F6
uniprot id: A0A3Q2UJY7
uniprot id: E1BZF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
messages: sarcolemma

9031:PYROXD1
gene id: 9031:PYROXD1
uniprot id: F1NPI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9031:FREM1
gene id: 9031:FREM1
uniprot id: F1P5W0
names: Similarity
messages: Belongs to the FRAS1 family.

9031:GJB1
gene id: 9031:GJB1
uniprot id: Q6URH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:IHH
gene id: 9031:IHH
uniprot id: Q98938
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hedgehog family.
messages: Binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.
messages: Cell membrane
messages: Cholesterylation is required for N-product targeting to lipid rafts and multimerization.
messages: Endoplasmic reticulum membrane
messages: Expressed in developing midgut, lung and cartilage of developing long bones in the limb.
messages: Golgi apparatus membrane
messages: Interacts with BOC and CDON. Interacts with PTCH1 (By similarity). Interacts with glypican GPC3 (By similarity).
messages: Multimer.
messages: N-palmitoylation by HHAT of N-product is required for indian hedgehog protein N-product multimerization and full activity.
messages: Secreted
messages: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). The N-product is the active species in both local and long-range signaling, whereas the C-product is degraded in the reticulum endoplasmic (By similarity).
messages: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity).
messages: The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton. Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy. In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (PubMed:8662546).

9031:FAM3D
gene id: 9031:FAM3D
uniprot id: E1C5S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9031:RALB
gene id: 9031:RALB
uniprot id: E1BVT0
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

9031:RASSF1
gene id: 9031:RASSF1
uniprot id: A0A1D5PTR2
names: Subcellular Location Annotation
messages: cytoskeleton

9031:LOX
gene id: 9031:LOX
uniprot id: Q05063
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: In addition to cross linking of extracellular matrix proteins, it may have a direct role in tumor suppression.
messages: Increases between day 8 and 16 of embryonic development, during aortic embryogenesis, in direct proportion to total protein synthesis.
messages: Proteolytically cleaved by BMP1 which removes the propeptide (By similarity). Also proteolytically cleaved by ADAMTS2 and ADAMTS14, but not by ADAMTS3, at an additional cleavage site downstream of the BMP1 cleavage site (By similarity). The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin (By similarity). Cleavage by BMP1 to remove the propeptide does not increase enzymatic activity but increases binding to collagen (By similarity). Cleavage by ADAMTS2 produces a form with reduced collagen-binding activity (By similarity).
messages: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin.
messages: Sulfated at Tyr-190 and also at either Tyr-186 or Tyr-187 which enhances binding to collagen.
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9031:F13A1
gene id: 9031:F13A1
uniprot id: Q9DER6
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9031:CSNK1D
gene id: 9031:CSNK1D
uniprot id: A0A1D5NXQ4
uniprot id: E1BVW0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:RRAGD
gene id: 9031:RRAGD
uniprot id: R4GK54
names: Similarity
messages: Belongs to the GTR/RAG GTP-binding protein family.

9031:DRD4
gene id: 9031:DRD4
uniprot id: B6UVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:TAF7
gene id: 9031:TAF7
uniprot id: F1NI87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

9031:MMP16
gene id: 9031:MMP16
uniprot id: A0A1D5PZ77
uniprot id: Q1EQ66
uniprot id: Q98947
names: Similarity
messages: Belongs to the peptidase M10A family.

9031:CD40
gene id: 9031:CD40
uniprot id: Q9DDD2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:CYR61
gene id: 9031:CYR61
uniprot id: P19336
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: By V-Src.
messages: Probable secreted regulatory protein.
messages: Secreted

9031:SSPO
gene id: 9031:SSPO
uniprot id: Q2PC93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thrombospondin family.
messages: Involved in the modulation of neuronal aggregation (By similarity). May be involved in developmental events during the formation of the central nervous system (By similarity).
messages: extracellular space

9031:FZD7
gene id: 9031:FZD7
uniprot id: O57329
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Expressed broadly in cranial ectoderm. Also expressed in the developing somites and in other cranial placodes, including the olfactory, lens, otic placodes (lateral half of the vesicle) and epibranchial placodes. Low level of expression in all the mesoderm derivatives in the limb buds.
messages: First detected as stage 6 in the forming neural tube and somites, but not in trunk surface ectoderm. By stage 8, expression persists in the cranial ectoderm and is up-regulated in the presomptive olfactory placodes. By stages 11-12, expression declines in the neural tube, but not in the cranial ectoderm; in somites, expressed all along the rostral-caudal axis as well as in presegmental mesenchyme caudal to the developing somites. Lens and otic placode expression first visible at stage 12, strongest at stages 13-16. Detected uniformly in ectoderm and mesenchyme of the limb primordia at stage 17. By stage 18, decrease of ectodermal, otic, lens and olfactory placode expression; expression appears in the epibranchial placodes. By stages 22-30, highest levels in the most distal mesoderm of the autopod, in the ventricular zone of the neural tube from the forebrain to the spinal cord, in the dermomyotomes and the tail buds.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
messages: The FZ domain is involved in binding with Wnt ligands.

9031:CRYBB2
gene id: 9031:CRYBB2
uniprot id: Q6QIF4
uniprot id: Q6QIF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

9031:TMEM59
gene id: 9031:TMEM59
uniprot id: Q5ZLJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:GARS
gene id: 9031:GARS
uniprot id: Q5ZHR4
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

9031:FUCA2
gene id: 9031:FUCA2
uniprot id: E1BS94
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9031:LOC771069
gene id: 9031:LOC771069
uniprot id: E1BUD0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:DDX6
gene id: 9031:DDX6
uniprot id: Q5ZKB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
messages: Cytoplasm
messages: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation.
messages: Nucleus
messages: P-body

9031:NOP58
gene id: 9031:NOP58
uniprot id: E1BUS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

9031:PSMD12
gene id: 9031:PSMD12
uniprot id: Q5ZI37
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9031:ADAM9
gene id: 9031:ADAM9
uniprot id: F1NSQ3
uniprot id: Q5ZJH4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TM4SF18
gene id: 9031:TM4SF18
uniprot id: A0A1D5NTF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9031:ERI1
gene id: 9031:ERI1
uniprot id: Q5ZL01
names: Subcellular Location Annotation
messages: Cytoplasm

9031:TPK1
gene id: 9031:TPK1
uniprot id: A0A1D5PYF4
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9031:DOLK
gene id: 9031:DOLK
uniprot id: R4GI61
names: Similarity
messages: Belongs to the polyprenol kinase family.

9031:KPTN
gene id: 9031:KPTN
uniprot id: A0A1D5PJB7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the KICSTOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Lysosome membrane
messages: May be part of the KICSTOR complex.
messages: lamellipodium
messages: stereocilium

9031:F7
gene id: 9031:F7
uniprot id: Q804X7
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
messages: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:PI4KA
gene id: 9031:PI4KA
uniprot id: A0A1D5NY86
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:PIAS4
gene id: 9031:PIAS4
uniprot id: A0A1D5P2D1
names: Similarity
messages: Belongs to the PIAS family.

9031:TRPC4
gene id: 9031:TRPC4
uniprot id: E1C0Y0
names: Subcellular Location Annotation
messages: Membrane

9031:PLA2G2A
gene id: 9031:PLA2G2A
uniprot id: H8Y6B2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9031:ATP1B4
gene id: 9031:ATP1B4
uniprot id: Q2HZ96
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Composed of two subunits: alpha (catalytic) and beta (accessory).
messages: Expressed in embryo in skeletal muscle, heart, brain, retina, inner ear and skin at 19 dpc.
messages: Expressed in skeletal muscle, intestine, heart, brain, retina, inner ear and skin.
messages: Glycosylated.
messages: Its function as a Na,K-ATPase beta-subunit will be lost in placental mammals.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9031:FAT3
gene id: 9031:FAT3
uniprot id: A0A1D5PJF9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ATP5B
gene id: 9031:ATP5B
uniprot id: Q5ZLC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion inner membrane

9031:GCNT7
gene id: 9031:GCNT7
uniprot id: E1C518
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9031:HIST2H3A
gene id: 9031:HIST2H3A
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:UPF1
gene id: 9031:UPF1
uniprot id: E1C0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

9031:STC2
gene id: 9031:STC2
uniprot id: E1BRJ2
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9031:SLC9A1
gene id: 9031:SLC9A1
uniprot id: Q1PS52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane

9031:EPN3
gene id: 9031:EPN3
uniprot id: F1NZR2
names: Similarity
messages: Belongs to the epsin family.

9031:LOC107056693
gene id: 9031:LOC107056693
uniprot id: E1BZK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9031:EIF2A
gene id: 9031:EIF2A
uniprot id: Q5ZKC1
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9031:SDHAF3
gene id: 9031:SDHAF3
uniprot id: R4GHE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

9031:DPEP2
gene id: 9031:DPEP2
uniprot id: F1NQJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9031:EDF1
gene id: 9031:EDF1
uniprot id: Q5ZMC0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable transcriptional coactivator.

9031:LOC396365
gene id: 9031:LOC396365
uniprot id: P09859
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Potent stimulus of gastric acid, but not of pancreatic secretion.
messages: Secreted

9031:ALX4
gene id: 9031:ALX4
uniprot id: O93582
names: Subcellular Location Annotation
messages: Nucleus

9031:FAM198B
gene id: 9031:FAM198B
uniprot id: A0A1D5PPI4
names: Similarity
messages: Belongs to the GASK family.

9031:MESDC2
gene id: 9031:MESDC2
uniprot id: R4GI40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

9031:DDR1
gene id: 9031:DDR1
uniprot id: A0A1D5PT01
uniprot id: Q5F3X2
names: Subcellular Location Annotation
messages: Membrane

9031:RAD18
gene id: 9031:RAD18
uniprot id: Q5ZIP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Nucleus

9031:COPS4
gene id: 9031:COPS4
uniprot id: Q5ZJV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9031:CA4
gene id: 9031:CA4
uniprot id: E1C004
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane

9031:SOX3
gene id: 9031:SOX3
uniprot id: Q9PSV6
names: Subcellular Location Annotation
messages: Nucleus

9031:ROR2
gene id: 9031:ROR2
uniprot id: A0SVH2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:HIST1H2B5
gene id: 9031:HIST1H2B5
uniprot id: P0C1H4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:KIF3C
gene id: 9031:KIF3C
uniprot id: R4GFP1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:LPL
gene id: 9031:LPL
uniprot id: P11602
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Ca(2+) binding promotes protein stability and formation of the active homodimer.
messages: Cell membrane
messages: Homodimer. Interacts with GPIHBP1 with 1:1 stoichiometry (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interaction with heparan sulfate proteoglycans is required to protect LPL against loss of activity. Associates with lipoprotein particles in blood plasma. Interacts with LMF1 and SEL1L; interaction with SEL1L is required to prevent aggregation of newly synthesized LPL in the endoplasmic reticulum (ER), and for normal export of LPL from the ER to the extracellular space (By similarity).
messages: Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (By similarity). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity).
messages: N-glycan at Asn-70 is a triantennary complex oligosaccharide containing sialic acid, galactose, mannose, and N-acetylglucosamine, the reducing GlcNAc being sulfated at C6.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9031:POR
gene id: 9031:POR
uniprot id: F1P2T2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

9031:LOC121106490
gene id: 9031:LOC121106490
uniprot id: A0A1D5P312
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:ADAMTS3
gene id: 9031:ADAMTS3
uniprot id: F1NVD1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:HSBP1
gene id: 9031:HSBP1
uniprot id: A0A1D5PAM4
names: Similarity
messages: Belongs to the HSBP1 family.

9031:ATG4B
gene id: 9031:ATG4B
uniprot id: Q6PZ02
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15140988). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: The LIR motif (LC3-interacting region) is required for the interaction with ATG8 family proteins. Required for proteolytic activation and delipidation of ATG8 proteins.
messages: autophagosome
messages: cytosol

9031:SLC6A13
gene id: 9031:SLC6A13
uniprot id: F1NN76
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Membrane

9031:FAM102A
gene id: 9031:FAM102A
uniprot id: E1BZB0
names: Similarity
messages: Belongs to the FAM102 family.

9031:OPN4
gene id: 9031:OPN4
uniprot id: F1NEY8
uniprot id: Q2KNE6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:C18orf21
gene id: 9031:C18orf21
uniprot id: A0A3Q2TXY8
names: Similarity
messages: Belongs to the UPF0711 family.

9031:NDUFAB1
gene id: 9031:NDUFAB1
uniprot id: E1C4C0
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9031:NDUFB5
gene id: 9031:NDUFB5
uniprot id: Q5ZK61
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.

9031:GOLGA7
gene id: 9031:GOLGA7
uniprot id: Q5ZLC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERF4 family.
messages: Golgi apparatus membrane
messages: Interacts with ZDHHC9.
messages: May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity).

9031:SBK2
gene id: 9031:SBK2
uniprot id: E1BXS6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:CDKN1B
gene id: 9031:CDKN1B
uniprot id: Q8JIV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

9031:EIF3E
gene id: 9031:EIF3E
uniprot id: Q5ZLA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Nucleus

9031:UBE2D1
gene id: 9031:UBE2D1
uniprot id: A0A1D5PNM7
uniprot id: E1BZJ2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:SUV39H2
gene id: 9031:SUV39H2
uniprot id: Q5F3W5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Nucleus
messages: centromere

9031:TACR2
gene id: 9031:TACR2
uniprot id: A0A8K1ER17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:ABHD17B
gene id: 9031:ABHD17B
uniprot id: Q5ZJ01
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Cell membrane
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization.
messages: Postsynaptic density membrane
messages: Recycling endosome membrane
messages: dendritic spine

9031:UBE2I
gene id: 9031:UBE2I
uniprot id: P63283
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Cytoplasm
messages: Interacts with SOX9.
messages: Nucleus

9031:CYB561A3
gene id: 9031:CYB561A3
uniprot id: A0A1L1RJW6
names: Subcellular Location Annotation
messages: Membrane

9031:PFDN4
gene id: 9031:PFDN4
uniprot id: F1NP43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9031:RPAP1
gene id: 9031:RPAP1
uniprot id: F1NLT1
names: Similarity
messages: Belongs to the RPAP1 family.

9031:PTS
gene id: 9031:PTS
uniprot id: F1NL99
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9031:FOS
gene id: 9031:FOS
uniprot id: P11939
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Fos subfamily.
messages: Endoplasmic reticulum
messages: Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
messages: Heterodimer. Interacts with MAFB.
messages: May be Tyr-phosphorylated in quiescent cells and dephosphorylated upon cell growth induction.
messages: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity).
messages: Nucleus
messages: cytosol

9031:KERA
gene id: 9031:KERA
uniprot id: O42235
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds keratan sulfate chains.
messages: Plays an important role in generating and maintaining a transparent matrix within the corneal stroma.
messages: extracellular matrix

9031:TTC26
gene id: 9031:TTC26
uniprot id: F1NK58
names: Similarity
messages: Belongs to the IFT56 family.

9031:ADAM19
gene id: 9031:ADAM19
uniprot id: E1AP05
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ANKRD44
gene id: 9031:ANKRD44
uniprot id: Q5F478
names: Function
names: Subunit
messages: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).
messages: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

9031:TESC
gene id: 9031:TESC
uniprot id: A0AVX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcineurin regulatory subunit family. CHP subfamily.
messages: Binds calcium via its EF-hands. Calcium-binding mediates a conformational change. Can also bind magnesium (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the bipotential gonad by E4.5 and expressed in both the testis and ovary by E5.5, but with expression higher in the testis. Expressed in the testis cords but also at low levels in the interstitium. In the ovary, expression is principally in the ovarian cortex, but also in the medulla. Also expressed in the embryonic brain, with expression highest in the region between the nasal placode and olfactory bulb. Also expressed in the embryonic heart and tail.
messages: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin (By similarity).
messages: Membrane
messages: Monomer (By similarity). Homodimer (By similarity).
messages: Nucleus
messages: lamellipodium
messages: ruffle membrane

9031:PPP1R2
gene id: 9031:PPP1R2
uniprot id: Q5F327
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9031:GNL2
gene id: 9031:GNL2
uniprot id: E1BVP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9031:MEF2B
gene id: 9031:MEF2B
uniprot id: A0A1D5P1A2
uniprot id: A0A3Q3A5B9
names: Subcellular Location Annotation
messages: Nucleus

9031:LUC7L3
gene id: 9031:LUC7L3
uniprot id: A0A1D5P7P5
uniprot id: F1NXR8
uniprot id: Q5ZIU4
names: Similarity
messages: Belongs to the Luc7 family.

9031:LOC415661
gene id: 9031:LOC415661
uniprot id: F1N9C1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:KCNH8
gene id: 9031:KCNH8
uniprot id: F1P320
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9031:TMEM33
gene id: 9031:TMEM33
uniprot id: E1BW27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9031:SNAPC3
gene id: 9031:SNAPC3
uniprot id: F1NW98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

9031:FASLG
gene id: 9031:FASLG
uniprot id: Q5CAQ0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9031:PAX7
gene id: 9031:PAX7
uniprot id: A5GZA7
uniprot id: O42349
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9031:GPRIN2
gene id: 9031:GPRIN2
uniprot id: F1P2U2
names: Function
messages: May be involved in neurite outgrowth.

9031:ZFYVE9
gene id: 9031:ZFYVE9
uniprot id: E1C6T3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9031:EVA1C
gene id: 9031:EVA1C
uniprot id: A0A3Q2U242
names: Similarity
messages: Belongs to the EVA1 family.

9031:BRIX1
gene id: 9031:BRIX1
uniprot id: Q5ZLV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9031:GPN2
gene id: 9031:GPN2
uniprot id: R4GIA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9031:CASD1
gene id: 9031:CASD1
uniprot id: F1NZ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

9031:NR5A1
gene id: 9031:NR5A1
uniprot id: E1BXV1
uniprot id: O42102
uniprot id: Q9PWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9031:IMMP2L
gene id: 9031:IMMP2L
uniprot id: E1BYB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

9031:SFXN2
gene id: 9031:SFXN2
uniprot id: F1NDD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9031:LDHA
gene id: 9031:LDHA
uniprot id: E1BTT8
uniprot id: P00340
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

9031:FAM175B
gene id: 9031:FAM175B
uniprot id: Q5F351
names: Subcellular Location Annotation
messages: Nucleus

9031:THEMIS2
gene id: 9031:THEMIS2
uniprot id: R4GIX2
names: Similarity
messages: Belongs to the themis family.

9031:BTAF1
gene id: 9031:BTAF1
uniprot id: A0A1D5P1T4
names: Subcellular Location Annotation
messages: Nucleus

9031:SSTR1
gene id: 9031:SSTR1
uniprot id: A9UGZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:GRK4
gene id: 9031:GRK4
uniprot id: Q5ZKL2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9031:MMP15
gene id: 9031:MMP15
uniprot id: A0A1D5PR25
names: Similarity
messages: Belongs to the peptidase M10A family.

9031:TIMP3
gene id: 9031:TIMP3
uniprot id: P26652
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli.
messages: extracellular matrix

9031:H2AZ2
gene id: 9031:H2AZ2
uniprot id: P02272
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5, Lys-8 and Lys-12 when associated with the 5'-end of active genes.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Expressed in the chicken embryo.
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AF forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).

9031:UBA5
gene id: 9031:UBA5
uniprot id: Q6IVA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Cytoplasm
messages: E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Homodimer; homodimerization is required for UFM1 activation. Interacts (via UIS motif) with UFM1; binds UFM1 via a trans-binding mechanism in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Interacts (via C-terminus) with UFC1.
messages: Nucleus

9031:SFXN1
gene id: 9031:SFXN1
uniprot id: A0A1D5PGI3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9031:PGD
gene id: 9031:PGD
uniprot id: Q5ZIZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

9031:CAPN6
gene id: 9031:CAPN6
uniprot id: E1C312
names: Similarity
messages: Belongs to the peptidase C2 family.

9031:PDSS2
gene id: 9031:PDSS2
uniprot id: E1C4Y7
uniprot id: U3M6H4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9031:PWP2
gene id: 9031:PWP2
uniprot id: A0A1L1RTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9031:AMDHD2
gene id: 9031:AMDHD2
uniprot id: F1P5J8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

9031:BCL6
gene id: 9031:BCL6
uniprot id: Q5ZM39
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation (By similarity).

9031:LOC100857947
gene id: 9031:LOC100857947
uniprot id: P42165
uniprot id: Q38IF1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears first at 3 hours post-infection, increases to give the strongest signal at about 9 hours and gradually wanes to almost nothing at 24 hours.
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:FSHR
gene id: 9031:FSHR
uniprot id: P79763
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB.

9031:NPEPL1
gene id: 9031:NPEPL1
uniprot id: F1NSZ4
names: Similarity
messages: Belongs to the peptidase M17 family.

9031:FABP9
gene id: 9031:FABP9
uniprot id: A0A1D5PJZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9031:PDGFRA
gene id: 9031:PDGFRA
uniprot id: F1N870
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9031:ATP9A
gene id: 9031:ATP9A
uniprot id: F1NUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:ATPAF2
gene id: 9031:ATPAF2
uniprot id: E1BUZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

9031:ASS1
gene id: 9031:ASS1
uniprot id: Q5ZJ23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family.
messages: Homotetramer.
messages: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
messages: cytosol

9031:REEP3
gene id: 9031:REEP3
uniprot id: F1NBY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9031:ESCO1
gene id: 9031:ESCO1
uniprot id: F1NTQ0
names: Subcellular Location Annotation
messages: Nucleus

9031:ACOT8
gene id: 9031:ACOT8
uniprot id: E1BVK8
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9031:SLA
gene id: 9031:SLA
uniprot id: A0A1D5PSA6
uniprot id: Q7T3X8
names: Subcellular Location Annotation
messages: Cytoplasm

9031:MGP
gene id: 9031:MGP
uniprot id: O42413
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: In 16-day-old embryo, expressed at high level in the sternum and tibia, at low level in skeletal muscle, heart and gizzard. Not present in skin, liver and brain.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9031:LOC769486
gene id: 9031:LOC769486
uniprot id: R4GLL2
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:IL10
gene id: 9031:IL10
uniprot id: B6RCP7
uniprot id: Q6A2H4
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IL-10 family.
messages: By lipopolysaccharide (LPS) in white blood cells, liver and spleen 3 hours after treatment. Decreases to basal levels 8 hours after treatment. By primary infection with E.acervulina and E.tenella.
messages: Chickens susceptible to E.maxima infection show higher constitutive and post-infection levels in spleen and higher post-infection levels in small intestine than infection-resistant animals.
messages: Expressed predominantly in bursa of Fabricius and cecal tonsils with low levels in thymus, liver and lung.
messages: Expression is detected as early as embryonic day 12. Higher expression in spleen of post-hatch chickens than embryos. Gradual increase in expression in the spleen which peaks by day 7 post-hatch.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Immune regulatory cytokine.
messages: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
messages: Secreted

9031:PYGL
gene id: 9031:PYGL
uniprot id: Q7ZZK3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9031:PSAP
gene id: 9031:PSAP
uniprot id: A0A1D5PAE3
uniprot id: A0A1L1RR94
uniprot id: E1BSP1
uniprot id: O13035
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Lysosome
messages: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
messages: Saposin-B is a homodimer.
messages: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.
messages: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).
messages: Secreted
messages: The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymatic proteins: the sphingolipids activator proteins (coproteins).
messages: This precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins.

9031:MRPL17
gene id: 9031:MRPL17
uniprot id: F1NHT8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

9031:EAF2
gene id: 9031:EAF2
uniprot id: Q5ZHP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF family.
messages: May act as a transcriptional transactivator.
messages: Nucleus speckle

9031:SCT
gene id: 9031:SCT
uniprot id: Q58G85
names: Similarity
messages: Belongs to the glucagon family.

9031:ACTA1
gene id: 9031:ACTA1
uniprot id: P68139
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:SLC7A2
gene id: 9031:SLC7A2
uniprot id: R4GH92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9031:ATP8B3
gene id: 9031:ATP8B3
uniprot id: F1NKB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:C11orf54
gene id: 9031:C11orf54
uniprot id: F1NY09
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

9031:LARGE2
gene id: 9031:LARGE2
uniprot id: Q66PG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity).
messages: Binds 2 Mn(2+) ions per subunit. The xylosyltransferase part binds one Mn(2+) and the beta-1,3-glucuronyltransferase part binds one Mn(2+).
messages: Golgi apparatus membrane
messages: In the C-terminal section; belongs to the glycosyltransferase 49 family.
messages: In the N-terminal section; belongs to the glycosyltransferase 8 family.

9031:ADRB3
gene id: 9031:ADRB3
uniprot id: A0A4P9IV16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:GJD4
gene id: 9031:GJD4
uniprot id: E1C7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:PSKH1
gene id: 9031:PSKH1
uniprot id: E1BX19
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:SURF4
gene id: 9031:SURF4
uniprot id: Q800K9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

9031:NTN4
gene id: 9031:NTN4
uniprot id: F1P4C0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:LOC428720
gene id: 9031:LOC428720
uniprot id: A0A3Q2UGZ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:GAPVD1
gene id: 9031:GAPVD1
uniprot id: A0A3Q2TVQ8
uniprot id: A0A3Q2U5Y6
uniprot id: E1C268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

9031:CPA2
gene id: 9031:CPA2
uniprot id: E1C2B2
names: Similarity
messages: Belongs to the peptidase M14 family.

9031:NF2
gene id: 9031:NF2
uniprot id: A0A1D5P9T0
uniprot id: Q5ZJB0
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9031:PDE6G
gene id: 9031:PDE6G
uniprot id: Q802E4
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9031:TERF2
gene id: 9031:TERF2
uniprot id: Q9PU53
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (By similarity).
messages: Highly expressed in embryo.
messages: Homodimer. Component of the shelterin complex (telosome) (By similarity). Interacts with TERF2IP/RAP1.
messages: Nucleus
messages: telomere

9031:PEX3
gene id: 9031:PEX3
uniprot id: E1BS88
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9031:TSTA3
gene id: 9031:TSTA3
uniprot id: A0A1D5PUF7
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9031:TMEM104
gene id: 9031:TMEM104
uniprot id: Q5F3I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM104 family.
messages: Membrane

9031:CCNC
gene id: 9031:CCNC
uniprot id: P55168
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
messages: Component of the Mediator complex. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II (By similarity).
messages: Nucleus

9031:LOC396008
gene id: 9031:LOC396008
uniprot id: P55806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.
messages: extracellular space

9031:PAQR8
gene id: 9031:PAQR8
uniprot id: Q5ZHZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9031:METTL6
gene id: 9031:METTL6
uniprot id: A0A1D5PBA2
uniprot id: A0A3Q2U5F1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9031:EXOSC2
gene id: 9031:EXOSC2
uniprot id: A0A1L1RZU7
uniprot id: Q5ZHN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9031:CD200R1A
gene id: 9031:CD200R1A
uniprot id: Q2YHT7
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CD200R family.
messages: Glycosylated.
messages: Highly expressed in macrophages, peripheral blood lymphocytes (PBL) and peripheral blood mononuclear cells (PBMC). Weakly expressed in bursa, thymus, spleen, liver and brain.
messages: Membrane
messages: Phosphorylated.
messages: Secreted

9031:ADAM20L
gene id: 9031:ADAM20L
uniprot id: Q76KT5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:QTRT2
gene id: 9031:QTRT2
uniprot id: Q5ZM96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

9031:TM9SF3
gene id: 9031:TM9SF3
uniprot id: F1NRG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9031:DDB2
gene id: 9031:DDB2
uniprot id: Q5ZJL7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Chromosome
messages: Component of the UV-DDB complex which includes DDB1 and DDB2 (By similarity). Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1), which includes CUL4A or CUL4B, DDB1, DDB2 and RBX1. DDB2 may function as the substrate recognition module within this complex. A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces DDB2. These targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins (By similarity).
messages: Interblade loops of the WD repeat region mediate most of the interaction with DNA. A hairpin between blades 5 and 6 inserts into DNA minor groove and mediates recognition of lesions and separation of the damaged and undamaged strands (By similarity).
messages: Nucleus
messages: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair.
messages: The DWD box is required for interaction with DDB1.

9031:RAB3GAP2
gene id: 9031:RAB3GAP2
uniprot id: E1BVG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

9031:MYOM2
gene id: 9031:MYOM2
uniprot id: Q02173
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Can be detected by day 10-13 in ovo, the content is gradually increased throughout the ovo development and reached its peak after hatching.
messages: Expressed in pectoralis and cardiac muscle.
messages: Is a structural constituent of myofibrillar M-band in striated muscle.

9031:CLP1
gene id: 9031:CLP1
uniprot id: Q5ZJL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by dicer1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

9031:PRKAR1B
gene id: 9031:PRKAR1B
uniprot id: A0A1D5PCI4
uniprot id: E1C2U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9031:MRPL37
gene id: 9031:MRPL37
uniprot id: Q5ZI69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL37 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9031:BORCS5
gene id: 9031:BORCS5
uniprot id: A0A1D5P955
uniprot id: Q5ZJA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

9031:INPP4B
gene id: 9031:INPP4B
uniprot id: A0A1D5PHT1
uniprot id: A0A1D5PYC2
uniprot id: E1C1Z8
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

9031:ITM2B
gene id: 9031:ITM2B
uniprot id: F1NM17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9031:HOXB6
gene id: 9031:HOXB6
uniprot id: A0A1D5PZQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9031:NDE1
gene id: 9031:NDE1
uniprot id: Q5ZMC9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nudE family.
messages: Phosphorylated in mitosis.
messages: Required for centrosome duplication and formation and function of the mitotic spindle.
messages: Self-associates. Interacts with PAFAH1B1 (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

9031:RPA1
gene id: 9031:RPA1
uniprot id: Q5ZJJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus
messages: PML body

9031:SLCO4A1
gene id: 9031:SLCO4A1
uniprot id: F1P5V0
uniprot id: Q5ZMP9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:TMEM132C
gene id: 9031:TMEM132C
uniprot id: F1NFW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9031:LOC426220
gene id: 9031:LOC426220
uniprot id: A0A3Q2UD25
names: Similarity
messages: Belongs to the avidin/streptavidin family.

9031:SMARCAL1
gene id: 9031:SMARCAL1
uniprot id: F1P0X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9031:TRIT1
gene id: 9031:TRIT1
uniprot id: E1C6R1
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

9031:SFXN5
gene id: 9031:SFXN5
uniprot id: E1BRX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

9031:CTNNAL1
gene id: 9031:CTNNAL1
uniprot id: F1NMC0
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

9031:CHRM5
gene id: 9031:CHRM5
uniprot id: F1P0I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9031:PALM
gene id: 9031:PALM
uniprot id: A0A1D5PFN2
uniprot id: A0A1L1RL66
names: Similarity
messages: Belongs to the paralemmin family.

9031:PLIN1
gene id: 9031:PLIN1
uniprot id: B2Z9X8
uniprot id: F1P088
names: Similarity
messages: Belongs to the perilipin family.

9031:MMP24
gene id: 9031:MMP24
uniprot id: A0A1D5P6V1
names: Similarity
messages: Belongs to the peptidase M10A family.

9031:TMEM245
gene id: 9031:TMEM245
uniprot id: A0A1D5PNV7
uniprot id: E1BSU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

9031:CACNB4
gene id: 9031:CACNB4
uniprot id: B6IDG5
uniprot id: B6IDG6
uniprot id: Q804I5
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

9031:COX15
gene id: 9031:COX15
uniprot id: F1NMU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9031:SEMA6B
gene id: 9031:SEMA6B
uniprot id: A0A3S5ZP31
uniprot id: E1BV84
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PPP6C
gene id: 9031:PPP6C
uniprot id: Q5ZIV0
names: Similarity
messages: Belongs to the PPP phosphatase family.

9031:FNDC3A
gene id: 9031:FNDC3A
uniprot id: Q5ZJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNDC3 family.
messages: Golgi apparatus membrane

9031:SEPTIN6
gene id: 9031:SEPTIN6
uniprot id: Q5ZM42
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:FTL
gene id: 9031:FTL
uniprot id: Q8AYG9
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9031:STOML3
gene id: 9031:STOML3
uniprot id: F1P588
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9031:F9
gene id: 9031:F9
uniprot id: Q804X6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease.
messages: Belongs to the peptidase S1 family.
messages: Calcium binds to the gamma-carboxyglutamic acid (Gla) residues in the Gla domain. Calcium can also bind, with stronger affinity, to another site beyond the Gla domain. Under physiological ion concentrations, Ca(2+) is displaced by Mg(2+) from some of the gammaglutamate residues in the N-terminal Gla domain. This leads to a subtle conformation change that may affect the interaction with its binding protein.
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Heterodimer of a light chain and a heavy chain; disulfide-linked.
messages: Secreted
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

9031:TFIP11
gene id: 9031:TFIP11
uniprot id: Q5ZII9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events.
messages: Nucleus

9031:NELL1
gene id: 9031:NELL1
uniprot id: A0A1D5PFI4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:AMD1
gene id: 9031:AMD1
uniprot id: Q5F484
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.

9031:XG
gene id: 9031:XG
uniprot id: R4GHW5
names: Similarity
messages: Belongs to the CD99 family.

9031:TLDC1
gene id: 9031:TLDC1
uniprot id: Q5ZJX5
names: Function
names: Subcellular Location Annotation
messages: Activates an alternative mTOR signaling to regulate cell proliferation and migration.
messages: Cytoplasm
messages: Lysosome
messages: Membrane

9031:EMC6
gene id: 9031:EMC6
uniprot id: A0A1L1RMS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:DBT
gene id: 9031:DBT
uniprot id: Q98UJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9031:RAB3GAP1
gene id: 9031:RAB3GAP1
uniprot id: E1BT09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

9031:RSPO3
gene id: 9031:RSPO3
uniprot id: M4M6X6
names: Similarity
messages: Belongs to the R-spondin family.

9031:TUBD1
gene id: 9031:TUBD1
uniprot id: A0A1D5PLB8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Nucleus
messages: centriole
messages: cilium

9031:BCAP29
gene id: 9031:BCAP29
uniprot id: E1C310
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9031:RBM22
gene id: 9031:RBM22
uniprot id: Q5ZM16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLT11 family.
messages: Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex.
messages: Cytoplasm
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.
messages: The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.

9031:ASRGL1
gene id: 9031:ASRGL1
uniprot id: F1P5N7
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9031:LAT2
gene id: 9031:LAT2
uniprot id: Q5S7W5
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells. May also be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization through the recruitment of GRB2.
messages: Phosphorylated on tyrosines following cross-linking of BCR; which induces the recruitment of GRB2.
messages: When phosphorylated, interacts with GRB2.

9031:WARS
gene id: 9031:WARS
uniprot id: E1C2Z5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9031:FSCN1
gene id: 9031:FSCN1
uniprot id: D5LPR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9031:MED14
gene id: 9031:MED14
uniprot id: E1BWJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:PSMB1
gene id: 9031:PSMB1
uniprot id: Q6JLB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9031:FAM171A1
gene id: 9031:FAM171A1
uniprot id: A0A3Q3AN52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9031:TLR5
gene id: 9031:TLR5
uniprot id: C4PCK0
uniprot id: Q4ZJ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9031:ERRFI1
gene id: 9031:ERRFI1
uniprot id: E1C8Y8
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9031:LRRC8D
gene id: 9031:LRRC8D
uniprot id: E1BYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9031:PDE6B
gene id: 9031:PDE6B
uniprot id: F1NA42
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:PRPS1L1
gene id: 9031:PRPS1L1
uniprot id: F1NIP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

9031:IL6
gene id: 9031:IL6
uniprot id: D9ZYR9
uniprot id: Q90YI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: Secreted

9031:NTNG2
gene id: 9031:NTNG2
uniprot id: F1NQC4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ANP32E
gene id: 9031:ANP32E
uniprot id: Q5F4A3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANP32 family.
messages: Component of a SWR1-like complex. Interacts with H2A.Z/H2AZ1 (By similarity).
messages: Cytoplasm
messages: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity).
messages: Nucleus
messages: The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AZ1.

9031:SRF
gene id: 9031:SRF
uniprot id: F6MF48
names: Subcellular Location Annotation
messages: Nucleus

9031:INSIG2
gene id: 9031:INSIG2
uniprot id: A0A1D5PAY5
uniprot id: Q5F3W2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with SCAP via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with SCAP; interaction is direct and only takes place in the presence of sterols; it prevents interaction between SCAP and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex; association is mediated via its interaction with SCAP and only takes place in the presence of sterols.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBPs to the Golgi. Sterol deprivation reduces oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs. Also regulates cholesterol synthesis by regulating degradation of HMGCR.
messages: The KxHxx motif mediates association with the coatomer complex.

9031:CLCN7
gene id: 9031:CLCN7
uniprot id: Q5ZL60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9031:PITPNM3
gene id: 9031:PITPNM3
uniprot id: A0A3Q2U2V7
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9031:SNAP25
gene id: 9031:SNAP25
uniprot id: P60878
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By similarity).
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with TRIM9, RIMS1 and SNAPIN. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Associates with the BLOC-1 complex. Isoform 1 and isoform 2 interact with BLOC1S6 (By similarity). Interacts with alpha-synuclein/SNCA (By similarity).
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity).

9031:GHRH
gene id: 9031:GHRH
uniprot id: Q1KNA7
uniprot id: Q1KNA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9031:ARRDC2
gene id: 9031:ARRDC2
uniprot id: A0A1D5PPI1
uniprot id: A0A3Q2UAZ5
names: Similarity
messages: Belongs to the arrestin family.

9031:CD47
gene id: 9031:CD47
uniprot id: Q5ZL65
uniprot id: Q6XFR0
uniprot id: Q6XFR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:RGS2
gene id: 9031:RGS2
uniprot id: Q7ZZS4
uniprot id: Q7ZZS5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

9031:FAM155B
gene id: 9031:FAM155B
uniprot id: A0A1D5PZ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

9031:CATH1
gene id: 9031:CATH1
uniprot id: C4PFJ7
uniprot id: Q6QLQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.
messages: Detected in gizzard, liver, small intestine, large intestine, cloaca, bursa of Fabricius, gall bladder, lung, trachea, kidney, testis and bone marrow.
messages: Secreted

9031:BCAN
gene id: 9031:BCAN
uniprot id: A0A3Q2U6L1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PNPLA6
gene id: 9031:PNPLA6
uniprot id: B0FLU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:CANX
gene id: 9031:CANX
uniprot id: A0A1D5PF08
uniprot id: Q5ZMF5
names: Similarity
messages: Belongs to the calreticulin family.

9031:SLC7A9
gene id: 9031:SLC7A9
uniprot id: E5L8B7
names: Subcellular Location Annotation
messages: Membrane

9031:GDPD1
gene id: 9031:GDPD1
uniprot id: F1NYV4
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:LOC100859500
gene id: 9031:LOC100859500
uniprot id: E1C602
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:NOX1
gene id: 9031:NOX1
uniprot id: A0A3Q2UE93
uniprot id: A7E3K3
names: Subcellular Location Annotation
messages: Membrane

9031:CA13
gene id: 9031:CA13
uniprot id: A0A1D5NX31
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9031:TUBA8B
gene id: 9031:TUBA8B
uniprot id: P08070
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: Testis specific.
messages: The MREC motif may be critical for tubulin autoregulation.
messages: There are at least seven alpha tubulin genes (alpha-1 to alpha-6, and alpha-8), and a pseudogene (alpha-7) in chicken.
messages: This tubulin does not have a C-terminal tyrosine.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:MFSD4B
gene id: 9031:MFSD4B
uniprot id: A0A3Q2UF69
names: Subcellular Location Annotation
messages: Membrane

9031:PSMC3IP
gene id: 9031:PSMC3IP
uniprot id: A0A1D5NXS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

9031:CASP1
gene id: 9031:CASP1
uniprot id: A0A3Q2TY24
uniprot id: F1P0X7
names: Similarity
messages: Belongs to the peptidase C14A family.

9031:TAF4
gene id: 9031:TAF4
uniprot id: E1BXA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

9031:DACT2
gene id: 9031:DACT2
uniprot id: A0A1D5NWD7
names: Similarity
messages: Belongs to the dapper family.

9031:SMAD2
gene id: 9031:SMAD2
uniprot id: Q8UWF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:ADAMTS20
gene id: 9031:ADAMTS20
uniprot id: A0A1D5P8Z5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:H2AFZ
gene id: 9031:H2AFZ
uniprot id: Q5ZMD6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

9031:DOCK11
gene id: 9031:DOCK11
uniprot id: A0A1D5PB65
uniprot id: F1N9K4
names: Similarity
messages: Belongs to the DOCK family.

9031:HMCES
gene id: 9031:HMCES
uniprot id: Q5ZJT1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SOS response-associated peptidase family.
messages: Chromosome
messages: Glu-127 is involved in sensing abasic sites in single-stranded DNA (ssDNA). His-202 stabilizes the abasic sites by forming a hydrogen bond with the O4' hydroxyl group.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).

9031:MON1A
gene id: 9031:MON1A
uniprot id: F1NBQ4
uniprot id: Q5ZIH2
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.
messages: Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes.

9031:L3MBTL3
gene id: 9031:L3MBTL3
uniprot id: A0A1D5PTN3
names: Subcellular Location Annotation
messages: Nucleus

9031:PI4K2B
gene id: 9031:PI4K2B
uniprot id: Q5ZIK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Cell membrane
messages: Contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: cytosol

9031:PRDM10
gene id: 9031:PRDM10
uniprot id: A0A1D5P8W1
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9031:GPRC5B
gene id: 9031:GPRC5B
uniprot id: A0A3Q3B1Z6
uniprot id: E1BT99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:ACSM4
gene id: 9031:ACSM4
uniprot id: A0A1D5PBY1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9031:TRMT61A
gene id: 9031:TRMT61A
uniprot id: F1NZ19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

9031:VAX1
gene id: 9031:VAX1
uniprot id: Q9PVN2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: First detected within the ventral eye at Hamburger-Hamilton (HH) stage 14 as the optic vesicle invaginates. Expression restricted to the ventral retina at HH stage 22 and at 4 dpc as well as later in development.
messages: Nucleus
messages: Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina.

9031:ZFP36L1
gene id: 9031:ZFP36L1
uniprot id: S5TQ07
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9031:DCP2
gene id: 9031:DCP2
uniprot id: A0A1D5P6G7
uniprot id: F1NS39
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

9031:HSP90AA1
gene id: 9031:HSP90AA1
uniprot id: P11501
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Melanosome
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from Hsp90 which acquires an open conformation for the next cycle.
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.

9031:RIPPLY3
gene id: 9031:RIPPLY3
uniprot id: A0A3Q2TVP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9031:MFAP1
gene id: 9031:MFAP1
uniprot id: R4GGG5
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9031:ORMDL1
gene id: 9031:ORMDL1
uniprot id: A0A1D5PR34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9031:RPL8
gene id: 9031:RPL8
uniprot id: F1NIX0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9031:PPP1R1B
gene id: 9031:PPP1R1B
uniprot id: A0A1L1RXZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein phosphatase inhibitor 1 family.
messages: Cytoplasm
messages: Inhibitor of protein-phosphatase 1.

9031:MVP
gene id: 9031:MVP
uniprot id: Q5ZMI4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Nucleus
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity).
messages: The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).

9031:UBE2D2
gene id: 9031:UBE2D2
uniprot id: A0A1D5P0Q4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:VPS33B
gene id: 9031:VPS33B
uniprot id: A0A3S5ZPB6
uniprot id: Q5ZL71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9031:HINT1
gene id: 9031:HINT1
uniprot id: A0A3Q2UBJ7
names: Similarity
messages: Belongs to the HINT family.

9031:SMPDL3B
gene id: 9031:SMPDL3B
uniprot id: F1N9C4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9031:VEGFA
gene id: 9031:VEGFA
uniprot id: P67964
uniprot id: Q540I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).
messages: Homodimer; disulfide-linked (By similarity). Also found as heterodimer with PGF (By similarity).

9031:ITPKC
gene id: 9031:ITPKC
uniprot id: A0A3Q2UD35
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9031:PMVK
gene id: 9031:PMVK
uniprot id: A0A1L1RT71
names: Subcellular Location Annotation
messages: cytosol

9031:MRPS23
gene id: 9031:MRPS23
uniprot id: E1C2E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

9031:CASP7
gene id: 9031:CASP7
uniprot id: F1NV61
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cleavage by different proteases, such as granzyme B (GZMB), caspase-1 (CASP1), caspase-8 (CASP8) or caspase-9 (CASP9) generate the two active subunits. Its involvement in different programmed cell death processes is probably specified by the protease that activates CASP7 (By similarity). Cleaved and activated by initiator caspases (CASP8 and/or CASP9), leading to execution phase of apoptosis (By similarity). Cleavage and maturation by GZMB regulates granzyme-mediated programmed cell death (By similarity). Cleaved and activated by CASP1 in response to bacterial infection (By similarity).
messages: During activation, the N-terminal disordered prodomain is removed by cleavage. Concomitantly, double cleavage gives rise to a large Caspase-7 subunit p20 and a small Caspase-7 subunit p11. The two large and two small subunits then assemble to form the active CASP7 complex. Can be cleaved and activated by different caspases, depending on the context (By similarity). Cleaved and activated by initiator caspases (CASP8 and/or CASP9), leading to execution phase of apoptosis (By similarity). Cleavage and maturation by GZMB regulates granzyme-mediated programmed cell death. Cleavage and maturation by CASP1 regulates pyroptosis (By similarity).
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.
messages: Nucleus
messages: Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:14583630). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (By similarity). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8 and/or CASP9), mediates execution of apoptosis by catalyzing cleavage of proteins (PubMed:14583630). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (By similarity). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (By similarity).
messages: cytosol
messages: extracellular space

9031:ZFHX4
gene id: 9031:ZFHX4
uniprot id: A0A3Q2U7X8
names: Subcellular Location Annotation
messages: Nucleus

9031:POLR2H
gene id: 9031:POLR2H
uniprot id: A0A1D5PCT2
uniprot id: A0A1D5PED8
uniprot id: E1BSD8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9031:FAM133B
gene id: 9031:FAM133B
uniprot id: Q5ZLM8
names: Similarity
messages: Belongs to the FAM133 family.

9031:UNC5D
gene id: 9031:UNC5D
uniprot id: A0A1D5P4F5
uniprot id: A0A1D5PNP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9031:ZPBP2
gene id: 9031:ZPBP2
uniprot id: Q6PVW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: May be implicated in the gamete interaction during fertilization.
messages: Secreted
messages: acrosome

9031:CD200R1B
gene id: 9031:CD200R1B
uniprot id: F1NPN8
uniprot id: Q2YHT5
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CD200R family.
messages: Expressed in peripheral blood lymphocytes (PBL) and peripheral blood mononuclear cells (PBMC).
messages: Membrane

9031:PARK7
gene id: 9031:PARK7
uniprot id: D5M8S2
uniprot id: Q8UW59
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C56 family.
messages: Cell membrane
messages: Cytoplasm
messages: Deglycase activity does not require glutathione as a cofactor, however, glycated glutathione constitutes a PARK7 substrate.
messages: Endoplasmic reticulum
messages: Glyoxylase activity previously reported may reflect in fact its deglycase activity.
messages: Homodimer.
messages: Membrane raft
messages: Mitochondrion
messages: Nucleus
messages: Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease. It is involved in neuroprotective mechanisms as well as cell growth and transformation. Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury io…
messages: Sumoylated on Lys-130; which is essential for cell-growth promoting activity and transforming activity.
messages: The protein deglycation activity has been ascribed to a TRIS buffer artifact by a publication, which has then been rebutted by clear biochemical experiments showing that PARK7 is a bona fide deglycase. Deglycase activity is even strengthened by a novel article that reports nucleotide deglycation activity.
messages: Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress.

9031:NEK7
gene id: 9031:NEK7
uniprot id: Q5F3P1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:PDE6D
gene id: 9031:PDE6D
uniprot id: A0A1D5P2A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

9031:LRP5
gene id: 9031:LRP5
uniprot id: Q5ZKF9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:FAM162BL
gene id: 9031:FAM162BL
uniprot id: F1NBN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9031:LOC395095
gene id: 9031:LOC395095
uniprot id: H9L3N2
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:GLP1R
gene id: 9031:GLP1R
uniprot id: B4ZY91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:MIGA1
gene id: 9031:MIGA1
uniprot id: F1NV42
names: Similarity
messages: Belongs to the mitoguardin family.

9031:FAM26E
gene id: 9031:FAM26E
uniprot id: Q5F482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9031:MAPK8IP3
gene id: 9031:MAPK8IP3
uniprot id: A0A3Q3A4R7
names: Similarity
messages: Belongs to the JIP scaffold family.

9031:GMNN
gene id: 9031:GMNN
uniprot id: F1NW42
uniprot id: Q5ZKE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9031:LECT1
gene id: 9031:LECT1
uniprot id: Q9PUU8
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
messages: Belongs to the chondromodulin-1 family.
messages: Bifunctional growth regulator. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity).
messages: Endomembrane system
messages: Expressed in the cartilage and in fetal precartilaginous tissues as well as in heart and eye.
messages: Expression onset occurs between stage 10 and stage 13.
messages: extracellular matrix

9031:GPR1
gene id: 9031:GPR1
uniprot id: F1NYB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9031:TOLLIP
gene id: 9031:TOLLIP
uniprot id: Q5ZK05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tollip family.
messages: Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.
messages: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity).
messages: Cytoplasm
messages: Early endosome
messages: Endosome
messages: Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain). Found in a complex with TOM1; interacts (via N-terminus) with TOM1 (via GAT domain); the interactions leads to TOM1-recruitment to endosomes and inhibition of TOLLIP binding to PtdIns(3)P (By similarity).
messages: The N-terminal TOM1-binding domain (residues 1-53) is a disordered domain that partially folds when bound to the GAT domain of TOM1.

9031:PPM1F
gene id: 9031:PPM1F
uniprot id: A0A1D5PLT1
names: Similarity
messages: Belongs to the PP2C family.

9031:APEH
gene id: 9031:APEH
uniprot id: Q5ZJB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

9031:KCNJ6
gene id: 9031:KCNJ6
uniprot id: A0A3Q2UNZ0
uniprot id: F1P0S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

9031:ADGRD1
gene id: 9031:ADGRD1
uniprot id: A0A1D5P588
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:DCBLD2
gene id: 9031:DCBLD2
uniprot id: A0A3Q2U3L2
uniprot id: Q5F3F4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ALPI
gene id: 9031:ALPI
uniprot id: E1C0U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

9031:FAS
gene id: 9031:FAS
uniprot id: F1P2Q5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

9031:JAK2
gene id: 9031:JAK2
uniprot id: F1NQU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system
messages: Nucleus

9031:H3F3B
gene id: 9031:H3F3B
uniprot id: P84247
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with ZMYND11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains (By similarity). Interacts with ZMYND11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me). Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9031:HTR4
gene id: 9031:HTR4
uniprot id: F1NJL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

9031:WIF1
gene id: 9031:WIF1
uniprot id: A0A1D5PHP9
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:LOC100859690
gene id: 9031:LOC100859690
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:SNAP23
gene id: 9031:SNAP23
uniprot id: E1BRL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

9031:CUL2
gene id: 9031:CUL2
uniprot id: A0A1D5PDA2
uniprot id: F1N829
uniprot id: Q5F385
names: Similarity
messages: Belongs to the cullin family.

9031:FURIN
gene id: 9031:FURIN
uniprot id: Q91000
names: Similarity
messages: Belongs to the peptidase S8 family.

9031:RNP
gene id: 9031:RNP
uniprot id: A9CDT7
names: Subcellular Location Annotation
messages: Secreted

9031:TDRD3
gene id: 9031:TDRD3
uniprot id: Q5ZMS6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of mRNA stress granules.
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By similarity).
messages: The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 'Arg-17' (H3R17me2a) and histones H4 'Arg-3', 2 tags for epigenetic transcriptional activation.

9031:P2RX1
gene id: 9031:P2RX1
uniprot id: Q8AWC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9031:SFRP2
gene id: 9031:SFRP2
uniprot id: Q9IA96
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: In embryo, expressed in developing neural structures as well as in heart, branchial arches and limb buds. First expressed at stage 7 in the neural plate with lower expression in the midline. By stage 9, expressed through out the developing neural tube with lower levels in the future posterior mesencephalon and rhombomere 3. In anterior regions, highest expression in the dorsal neural tube and, more posteriorly throughout the closing neural tube. Also expressed in the ectoderm flanking the neural tube. In the developing brain, expression found in the presumptive forbrain. By stage 12, expression restricted to the dorsal prosencephalon, hindbrain and posterior neural tube. In the placodes, first expressed at stage 11, in the otic placode. By stage 15, expressed in the olfactory and epibranchial placodes. In facial primordia, expression found at stage 2,0 throughout the ectoderm. By stage 24, high mesenchymal expression in a small region of the posterior maxillary primordia, and in the lateral region of the mandibular primordia. By stage 28, expressed in a subset of muscles, including the intermandibularis muscle and the muscle medial to the eye. In the developing trunk, expression found throughout the dermamyotome in the more developed somites. By stage 20, expression restricted to the small region in the dorsal medial lip in all somites. In addition, also expressed in the ventral lateral lip of the dermamyotome that gives rise to the muscles of the limbs and body wall. During limb development, expressed between stages 20 and 30, in the proximal mesenchyme in association with developing muscles. Between stages 27 and 30, expression found in mesenchyme containing undifferentiated myogenic cells. In the developing heart, expression restricted to the myocardial and endocardial cell layers of the trabeculae in the ventricular compartment between stages 20 and 28.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 appears to be associated with myogenesis.
messages: The FZ domain is involved in binding with Wnt ligands.

9031:LOC419677
gene id: 9031:LOC419677
uniprot id: A0A3Q2ULP7
uniprot id: E1C8F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

9031:PSMC3
gene id: 9031:PSMC3
uniprot id: Q5ZIT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

9031:PDE6H
gene id: 9031:PDE6H
uniprot id: Q802E3
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9031:TGFB1
gene id: 9031:TGFB1
uniprot id: H9CX01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

9031:LANCL2
gene id: 9031:LANCL2
uniprot id: A0A1D5PY54
names: Similarity
messages: Belongs to the LanC-like protein family.

9031:OCLN
gene id: 9031:OCLN
uniprot id: Q91049
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Interacts with TJP1 and TJP3.
messages: Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in lung and liver. Expressed at a lower level in brain.
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1.
messages: Phosphorylated.
messages: The C-terminal is cytoplasmic and is important for interaction with ZO-1. Necessary for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction. The second extracellular domain may also be implicated in the permeability barrier function of the tight junction.
messages: tight junction

9031:COQ9
gene id: 9031:COQ9
uniprot id: F1P310
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

9031:FNIP2
gene id: 9031:FNIP2
uniprot id: A0A3Q2U091
uniprot id: A0A3Q2U512
uniprot id: F1NVA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9031:EIF1
gene id: 9031:EIF1
uniprot id: R4GLE6
names: Similarity
messages: Belongs to the SUI1 family.

9031:NSUN2
gene id: 9031:NSUN2
uniprot id: Q5ZLV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.
messages: Cytoplasm
messages: Mitochondrion
messages: RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs). Also mediates C(5)-methylation of mitochondrial tRNAs. Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay. Cytosine C(5)-methylation of mRNAs also regulates mRNA export. Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity.
messages: extracellular exosome
messages: nucleolus
messages: spindle

9031:TMEM206
gene id: 9031:TMEM206
uniprot id: A0A1D5PH61
uniprot id: A0A1D5PSZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9031:FCF1
gene id: 9031:FCF1
uniprot id: A0A1L1RUD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

9031:HOGA1
gene id: 9031:HOGA1
uniprot id: E1C1D7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9031:UCHL5
gene id: 9031:UCHL5
uniprot id: Q5ZKF1
names: Similarity
messages: Belongs to the peptidase C12 family.

9031:SMIM5
gene id: 9031:SMIM5
uniprot id: E1C7Q5
names: Subcellular Location Annotation
messages: Membrane

9031:PIGL
gene id: 9031:PIGL
uniprot id: F1NQ74
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

9031:ATP23
gene id: 9031:ATP23
uniprot id: E1C7J8
names: Similarity
messages: Belongs to the peptidase M76 family.

9031:PFN3
gene id: 9031:PFN3
uniprot id: E1BXG1
names: Similarity
messages: Belongs to the profilin family.

9031:ARRDC4
gene id: 9031:ARRDC4
uniprot id: E1C9I4
names: Similarity
messages: Belongs to the arrestin family.

9031:CA10
gene id: 9031:CA10
uniprot id: E1C7J1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9031:WDR45B
gene id: 9031:WDR45B
uniprot id: Q5ZL16
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2.
messages: Lysosome
messages: Preautophagosomal structure
messages: The L/FRRG motif is required for recruitment to PtdIns3P.

9031:ZDHHC21
gene id: 9031:ZDHHC21
uniprot id: Q5F3P6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:BNIP3L
gene id: 9031:BNIP3L
uniprot id: Q5ZLK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

9031:NDUFB9
gene id: 9031:NDUFB9
uniprot id: A0A1D5PNM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:STK17A
gene id: 9031:STK17A
uniprot id: Q5ZMU4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:MURC
gene id: 9031:MURC
uniprot id: R4GKM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

9031:CDO1
gene id: 9031:CDO1
uniprot id: E1C9J4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9031:GDPD4
gene id: 9031:GDPD4
uniprot id: F1NRU6
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:SEPTIN8
gene id: 9031:SEPTIN8
uniprot id: A0A3Q2U387
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:TAF1B
gene id: 9031:TAF1B
uniprot id: Q5ZJR9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (By similarity).
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity).
messages: nucleolus

9031:ATM
gene id: 9031:ATM
uniprot id: E1C0Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus

9031:PSMD6
gene id: 9031:PSMD6
uniprot id: F1N903
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

9031:GJD2
gene id: 9031:GJD2
uniprot id: Q8UVE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:KLHL20
gene id: 9031:KLHL20
uniprot id: Q5ZKD9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL20 and RBX1.
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity).
messages: perinuclear region

9031:TMEM136
gene id: 9031:TMEM136
uniprot id: R4GKY2
names: Subcellular Location Annotation
messages: Membrane

9031:ERG28
gene id: 9031:ERG28
uniprot id: A0A1D5PJH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:NTM
gene id: 9031:NTM
uniprot id: Q90773
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. IgLON family.
messages: Cell membrane
messages: Expressed by developing cerebellar Purkinje cells. Expression coincides with the growth of the dendritic tree, after Purkinje cells have finished their migration from the ventricular zone (from 15 dpc until 21 dpc). Expressed in the adult.
messages: Found on the dendrites, somata and axons of developing Purkinje cells. Undetectable on other neurons like Golgi or granule cells.
messages: Interacts with NEGR1.
messages: It may be a cellular address molecule specific to Purkinje cells. It may represent a receptor or a subunit of a receptor complex.

9031:CRYAA
gene id: 9031:CRYAA
uniprot id: A3FMM9
uniprot id: P02504
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. May act as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Cytoplasm
messages: Heteropolymer composed of three CRYAA and one CRYAB subunits (By similarity). Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and homotetramers (dimers of dimers) which serve as the building blocks of homooligomers (By similarity). Within homooligomers, the zinc-binding motif is created from residues of 3 different molecules. His-100 and Glu-102 from one molecule are ligands of the zinc ion, and His-107 and His-154 residues from additional molecules complete the site with tetrahedral coordination geometry (By similarity).
messages: Nucleus

9031:TNIP2
gene id: 9031:TNIP2
uniprot id: A0A1D5NW22
names: Subcellular Location Annotation
messages: Cytoplasm

9031:MED10
gene id: 9031:MED10
uniprot id: R4GFY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:SMARCA4
gene id: 9031:SMARCA4
uniprot id: Q90753
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9031:POU1F1
gene id: 9031:POU1F1
uniprot id: O57599
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus

9031:RPF1
gene id: 9031:RPF1
uniprot id: F1NRK2
names: Subcellular Location Annotation
messages: nucleolus

9031:RAB4A
gene id: 9031:RAB4A
uniprot id: A0A1D5NWR3
uniprot id: A0A3Q2TYP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

9031:CMTM7
gene id: 9031:CMTM7
uniprot id: Q5ZLJ3
names: Subcellular Location Annotation
messages: Membrane

9031:CHMP1B
gene id: 9031:CHMP1B
uniprot id: Q5ZKX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome
messages: Late endosome membrane
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III).
messages: cytosol

9031:ACTN4
gene id: 9031:ACTN4
uniprot id: Q90734
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-actinin family.
messages: Cell junction
messages: Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif that may mediate interaction with nuclear receptors.
messages: Cytoplasm
messages: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. Involved in tight junction assembly in epithelial cells. May also function as a transcriptional coactivator, stimulating transcription mediated by nuclear hormone receptors.
messages: Homodimer; antiparallel. Component of the CART complex. May interact with nuclear receptors.
messages: Nucleus
messages: perinuclear region

9031:TM9SF2
gene id: 9031:TM9SF2
uniprot id: F1P0L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9031:HOXC8
gene id: 9031:HOXC8
uniprot id: Q9YH13
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
messages: Transcripts are present at 3.5 dpc in the somitic cells, which give rise to the dorsal dermis by 5 dpc, and at 6.5 dpc to 8.5 dpc in the dorsal dermal and epidermal cells during the first stages of feather morphogenesis.

9031:CCND3
gene id: 9031:CCND3
uniprot id: Q5ZKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

9031:TAC3
gene id: 9031:TAC3
uniprot id: A0A8K1AZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

9031:DBNDD1
gene id: 9031:DBNDD1
uniprot id: A0A1D5P7Y7
uniprot id: F1NLB7
names: Similarity
messages: Belongs to the dysbindin family.

9031:SIRT5
gene id: 9031:SIRT5
uniprot id: E1BRE2
uniprot id: R9PXP3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-101 and Arg-104) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
messages: Nucleus
messages: cytosol

9031:CRBN
gene id: 9031:CRBN
uniprot id: F1P3S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9031:PLA2G4B
gene id: 9031:PLA2G4B
uniprot id: E1BWG9
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9031:CUL1
gene id: 9031:CUL1
uniprot id: A0A1D5P2L3
names: Similarity
messages: Belongs to the cullin family.

9031:FST
gene id: 9031:FST
uniprot id: Q90844
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds directly to activin and functions as an activin antagonist. Inhibits activin A signaling in the iris and regulates somatostatin phenotype in ciliary ganglion neurons. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
messages: Ciliary ganglion neurons. Levels are higher in the iris than the choroid.
messages: Levels increase in the iris from embryonic day 9 (9 dpc) to 16 dpc in contrast to the choroid where it remains low relative to iris. During early hindbrain development strongly expressed in rhombomeres R2, R4, R5 and R6 but not in R3. Expression in R3 is seen at later stages and is dependent on neighboring interactions.
messages: Monomer.
messages: Secreted

9031:ADAT1
gene id: 9031:ADAT1
uniprot id: Q5ZI16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ADAT1 family.
messages: Binds 1 myo-inositol hexakisphosphate (IP6) per subunit.
messages: Specifically deaminates adenosine-37 to inosine in tRNA-Ala.

9031:ADD1
gene id: 9031:ADD1
uniprot id: F1ND55
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9031:HRH4
gene id: 9031:HRH4
uniprot id: R4GJQ4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:SERINC1
gene id: 9031:SERINC1
uniprot id: Q5ZME5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9031:GTF2B
gene id: 9031:GTF2B
uniprot id: A0A1D5P699
uniprot id: F1NXP2
names: Similarity
messages: Belongs to the TFIIB family.

9031:LOC422895
gene id: 9031:LOC422895
uniprot id: A0A1D5NYM3
names: Subcellular Location Annotation
messages: Secreted

9031:TRIM3
gene id: 9031:TRIM3
uniprot id: A0A1D5PTL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

9031:KIF18A
gene id: 9031:KIF18A
uniprot id: A0A3Q3A508
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:SLC37A4
gene id: 9031:SLC37A4
uniprot id: F1NTH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9031:LYPLA1
gene id: 9031:LYPLA1
uniprot id: A0A1D5P263
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9031:LOC416197
gene id: 9031:LOC416197
uniprot id: F1NHZ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:SMOC1
gene id: 9031:SMOC1
uniprot id: F1NY60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ADA
gene id: 9031:ADA
uniprot id: Q5ZKP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity).
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle lumen
messages: Lysosome

9031:OSBPL3
gene id: 9031:OSBPL3
uniprot id: A0A1D5P497
names: Similarity
messages: Belongs to the OSBP family.

9031:MED31
gene id: 9031:MED31
uniprot id: A0A1D5PK99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:TMEM11
gene id: 9031:TMEM11
uniprot id: Q5ZLD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

9031:ZNF330
gene id: 9031:ZNF330
uniprot id: A0A1L1RUJ1
uniprot id: E1C2N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

9031:INO80C
gene id: 9031:INO80C
uniprot id: A0A3Q2U931
names: Subcellular Location Annotation
messages: Nucleus

9031:TRMT2A
gene id: 9031:TRMT2A
uniprot id: F1P0L5
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TRMU
gene id: 9031:TRMU
uniprot id: Q5ZKW0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
messages: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
messages: Mitochondrion

9031:CTDSPL
gene id: 9031:CTDSPL
uniprot id: Q9PTJ6
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per monomer.
messages: Monomer (By similarity). Interacts with LDB1.
messages: Nucleus
messages: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity).

9031:VNN2
gene id: 9031:VNN2
uniprot id: Q5ZHM4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

9031:HOXD4
gene id: 9031:HOXD4
uniprot id: F1NZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9031:KCNH6
gene id: 9031:KCNH6
uniprot id: A0A1I7Q433
uniprot id: A0A3Q2TWF6
names: Subcellular Location Annotation
messages: Membrane

9031:CXCL13L2
gene id: 9031:CXCL13L2
uniprot id: F1NBL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9031:NSRP1
gene id: 9031:NSRP1
uniprot id: F1P283
names: Similarity
messages: Belongs to the NSRP1 family.

9031:CAMLG
gene id: 9031:CAMLG
uniprot id: Q90700
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9031:ST7
gene id: 9031:ST7
uniprot id: A0A1D5PC10
uniprot id: A0A1D5PS55
uniprot id: A0M8U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9031:RHO
gene id: 9031:RHO
uniprot id: P22328
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.
messages: Membrane
messages: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
messages: photoreceptor outer segment

9031:TLR15
gene id: 9031:TLR15
uniprot id: Q2XQ10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane

9031:NDUFA12
gene id: 9031:NDUFA12
uniprot id: D5M8S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:DYNLT1
gene id: 9031:DYNLT1
uniprot id: A0A3Q2U8X6
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9031:LOC769841
gene id: 9031:LOC769841
uniprot id: A0A3Q3AE17
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:HCRTR2
gene id: 9031:HCRTR2
uniprot id: Q5TMB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SDHAF2
gene id: 9031:SDHAF2
uniprot id: A0A1D5PN62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9031:OSBPL8
gene id: 9031:OSBPL8
uniprot id: A0A1D5PGC8
uniprot id: A0A3Q3AQG0
names: Similarity
messages: Belongs to the OSBP family.

9031:ARV1
gene id: 9031:ARV1
uniprot id: F1NRD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

9031:ODC
gene id: 9031:ODC
uniprot id: F1NKA3
uniprot id: P27118
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
messages: Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.
messages: Inhibited by antizymes (AZs) in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.

9031:CLRN3
gene id: 9031:CLRN3
uniprot id: E1C5V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9031:EBF2
gene id: 9031:EBF2
uniprot id: E1C814
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9031:GINS1
gene id: 9031:GINS1
uniprot id: Q5F333
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

9031:GMPR2
gene id: 9031:GMPR2
uniprot id: Q5ZJA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9031:CPLX1
gene id: 9031:CPLX1
uniprot id: E1C8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9031:DACT1
gene id: 9031:DACT1
uniprot id: Q1G7H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm

9031:TFCP2
gene id: 9031:TFCP2
uniprot id: A7VJA9
uniprot id: Q7T2U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Binds the B-response element 5'-CAAGTCCAGGCAAGT-3' of the ENS1/ERNI promoter. May be the major transcription activator thus being essential for its expression.
messages: Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.
messages: Expressed in the epiblast at the pre-primitive streak stage. At the primitive streak stage, expressed in the extending primitive streak and in the prospective neural plate. At stages 7 and 8, expressed in the neural folds, somites and in the regressing primitive streak. At stage 12, ubiquitously expressed in the whole embryo.
messages: Nucleus

9031:B3GAT1
gene id: 9031:B3GAT1
uniprot id: F1NH16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:CYB561
gene id: 9031:CYB561
uniprot id: E1C8U5
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

9031:NTN1
gene id: 9031:NTN1
uniprot id: Q90922
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.
messages: Secreted

9031:HMGN4
gene id: 9031:HMGN4
uniprot id: P02314
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
messages: Nucleus

9031:LPCAT2
gene id: 9031:LPCAT2
uniprot id: Q5ZIX5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:TMEM163
gene id: 9031:TMEM163
uniprot id: F1NEL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: May bind zinc and other divalent cations and recruit them to vesicular organelles.
messages: Membrane
messages: synaptic vesicle membrane

9031:INTS8
gene id: 9031:INTS8
uniprot id: A0A1D5P482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

9031:TRDMT1
gene id: 9031:TRDMT1
uniprot id: A0A1D5PG43
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

9031:ANO10
gene id: 9031:ANO10
uniprot id: A0A1D5P0N6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SSRP1
gene id: 9031:SSRP1
uniprot id: B6ZLK1
uniprot id: Q04678
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity).
messages: Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also a component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B (By similarity).
messages: Nucleus
messages: nucleolus

9031:SDR42E2
gene id: 9031:SDR42E2
uniprot id: E1C196
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9031:C2H6orf52
gene id: 9031:C2H6orf52
uniprot id: A0A1D5NX87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Nucleus

9031:CTNNBL1
gene id: 9031:CTNNBL1
uniprot id: E1BW50
names: Subcellular Location Annotation
messages: Nucleus

9031:HARS2
gene id: 9031:HARS2
uniprot id: A0A1D5P330
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9031:TFAP2A
gene id: 9031:TFAP2A
uniprot id: O13111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9031:XYLB
gene id: 9031:XYLB
uniprot id: A0A1D5PKV6
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9031:PTP4A2
gene id: 9031:PTP4A2
uniprot id: A0A1D5PVR6
uniprot id: F1NLG3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9031:MTOR
gene id: 9031:MTOR
uniprot id: F1NUX4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9031:FADS1
gene id: 9031:FADS1
uniprot id: A0A3S5ZP86
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

9031:PYCRL
gene id: 9031:PYCRL
uniprot id: A0A1D5NV93
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9031:NME7
gene id: 9031:NME7
uniprot id: A0A3Q3AFZ3
uniprot id: E1C3P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9031:IL1RAP
gene id: 9031:IL1RAP
uniprot id: A0A1D5P4S3
uniprot id: A0A3Q2UNW5
uniprot id: E1C117
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9031:TRHR
gene id: 9031:TRHR
uniprot id: O93603
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9031:PSMC5
gene id: 9031:PSMC5
uniprot id: F1NU79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9031:CP
gene id: 9031:CP
uniprot id: A0A3Q3B296
names: Similarity
messages: Belongs to the multicopper oxidase family.

9031:KCNMA1
gene id: 9031:KCNMA1
uniprot id: Q8AYS8
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity).
messages: Homotetramer; which constitutes the calcium-activated potassium channel.
messages: It is uncertain whether Met-1 is the initiator or if the sequence starts further upstream.
messages: Membrane
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S0 segment is essential for the modulation by the accessory beta subunits.
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors regions required for activation of the channel (By similarity).
messages: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation (By similarity).
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
messages: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).

9031:GMFB
gene id: 9031:GMFB
uniprot id: Q5ZJ22
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9031:LOC431653
gene id: 9031:LOC431653
uniprot id: R4GGR1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9031:C7
gene id: 9031:C7
uniprot id: F1DQG4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:ING1
gene id: 9031:ING1
uniprot id: A0A1D5PZI6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9031:TBL3
gene id: 9031:TBL3
uniprot id: Q5ZMD3
names: Subcellular Location Annotation
messages: nucleolus

9031:DCN
gene id: 9031:DCN
uniprot id: P28675
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, to fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN (By similarity).
messages: May affect the rate of fibrils formation.
messages: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
messages: extracellular matrix

9031:PPFIBP1
gene id: 9031:PPFIBP1
uniprot id: A0A3Q2U4S7
uniprot id: Q5F3X7
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9031:RUNX2
gene id: 9031:RUNX2
uniprot id: Q8UVG3
names: Subcellular Location Annotation
messages: Nucleus

9031:VDAC2
gene id: 9031:VDAC2
uniprot id: F6T197
uniprot id: Q9I9D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Mitochondrion outer membrane

9031:CA9
gene id: 9031:CA9
uniprot id: F1NIF0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9031:RAD9A
gene id: 9031:RAD9A
uniprot id: Q76F79
names: Similarity
messages: Belongs to the rad9 family.

9031:DOK3
gene id: 9031:DOK3
uniprot id: A3R064
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DOK family. Type A subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Plays a role as negative regulator of the mobilization of calcium ions and of calcium signaling.
messages: Homooligomer. Interacts with GRB2 and INPP5D/SHIP.
messages: PTB domain mediates receptor interaction.
messages: Tyrosine-phosphorylated in the presence of GRB2.

9031:CCNE1
gene id: 9031:CCNE1
uniprot id: P49707
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin E subfamily.
messages: Essential for the control of the cell cycle at the G1/S (start) transition.
messages: Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (By similarity).
messages: Nucleus
messages: Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.

9031:PLA2G10L
gene id: 9031:PLA2G10L
uniprot id: E1C202
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9031:DCLRE1C
gene id: 9031:DCLRE1C
uniprot id: Q5QJC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Interacts with PRKDC.
messages: Nucleus
messages: Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening (By similarity).
messages: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity).

9031:KHDRBS3
gene id: 9031:KHDRBS3
uniprot id: A0A1D5NXQ0
uniprot id: A0A1D5PBZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDRBS family.
messages: Cytoplasm

9031:WNT11
gene id: 9031:WNT11
uniprot id: P49339
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Expressed during embryogenesis.
messages: Expressed in the dermatome. The expression domain is mutually exclusive to the other Wnt genes.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

9031:SURF1
gene id: 9031:SURF1
uniprot id: Q800L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: May play a role in mitochondrial respiratory chain complex IV assembly. Probably involved in the biogenesis of the COX complex.
messages: Mitochondrion inner membrane

9031:SNRPD3
gene id: 9031:SNRPD3
uniprot id: Q5ZL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

9031:SCO2
gene id: 9031:SCO2
uniprot id: A0A3Q2U072
names: Similarity
messages: Belongs to the SCO1/2 family.

9031:CDC42
gene id: 9031:CDC42
uniprot id: A0A1D5PD33
uniprot id: Q90694
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
messages: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
messages: centrosome
messages: dendrite
messages: spindle

9031:GPR25
gene id: 9031:GPR25
uniprot id: A0A2Z2CBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:PITHD1
gene id: 9031:PITHD1
uniprot id: F1P371
names: Similarity
messages: Belongs to the PITHD1 family.

9031:OST4
gene id: 9031:OST4
uniprot id: A0A1D5PXP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:ABRACL
gene id: 9031:ABRACL
uniprot id: F1NZC1
names: Similarity
messages: Belongs to the costars family.

9031:IPO8
gene id: 9031:IPO8
uniprot id: A0A1D5PPJ3
names: Subcellular Location Annotation
messages: Cytoplasm

9031:DICER1
gene id: 9031:DICER1
uniprot id: Q25BN1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. Dicer subfamily.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC (By similarity).
messages: Cytoplasm
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity).
messages: It is uncertain whether Met-1 or Met-11 is the initiator.

9031:LOC423605
gene id: 9031:LOC423605
uniprot id: A0A1D5PBP0
names: Subcellular Location Annotation
messages: Secreted

9031:PLK1
gene id: 9031:PLK1
uniprot id: Q5ZJ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

9031:THSD1
gene id: 9031:THSD1
uniprot id: R4GFI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plasmodium circumsporozoite protein family.
messages: Cell membrane
messages: Cytoplasm
messages: In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.
messages: Membrane

9031:MBNL1
gene id: 9031:MBNL1
uniprot id: Q5ZKW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the muscleblind family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA (By similarity).
messages: Nucleus

9031:NR2E3
gene id: 9031:NR2E3
uniprot id: Q90WV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:DNM1
gene id: 9031:DNM1
uniprot id: A0A3Q2U7G4
uniprot id: E1BXY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

9031:B4GALT4
gene id: 9031:B4GALT4
uniprot id: E1C9B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:ATP7B
gene id: 9031:ATP7B
uniprot id: A0A3Q2U105
uniprot id: F1P5C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9031:SLC6A17
gene id: 9031:SLC6A17
uniprot id: F1NS02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:USP7
gene id: 9031:USP7
uniprot id: A0A1D5PPD3
uniprot id: Q6U7I1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Chromosome
messages: Cytoplasm
messages: Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling.
messages: Nucleus
messages: PML body
messages: Phosphorylated.
messages: Polyneddylated.
messages: Polyubiquitinated.

9031:ATXN10
gene id: 9031:ATXN10
uniprot id: A0A1D5PLC3
uniprot id: E1C7R6
names: Function
names: Similarity
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.

9031:PRPS2
gene id: 9031:PRPS2
uniprot id: Q5ZI49
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3-bisphosphoglyceride or GDP (By similarity).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).

9031:RELL2
gene id: 9031:RELL2
uniprot id: R4GKS0
names: Similarity
messages: Belongs to the RELT family.

9031:ITGB8
gene id: 9031:ITGB8
uniprot id: A0A1D5PZX6
uniprot id: F1NJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9031:SLITRK1
gene id: 9031:SLITRK1
uniprot id: F1NZH0
names: Similarity
messages: Belongs to the SLITRK family.

9031:SERPINB1
gene id: 9031:SERPINB1
uniprot id: A0A3Q2TTT6
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

9031:NPR3
gene id: 9031:NPR3
uniprot id: A0A1D5PZA8
names: Subcellular Location Annotation
messages: Membrane

9031:EIF3D
gene id: 9031:EIF3D
uniprot id: F1NCE1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Cytoplasm
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

9031:ACTBL2
gene id: 9031:ACTBL2
uniprot id: A0A1D5NV17
names: Similarity
messages: Belongs to the actin family.

9031:MASP1
gene id: 9031:MASP1
uniprot id: Q6Q1Q8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CBFA2T3
gene id: 9031:CBFA2T3
uniprot id: Q5F3B1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBFA2T family.
messages: Expressed in the spinal cord of stage 22 embryos. Expressed during neurogenesis in the mantle zone of the spinal cord in domains corresponding to interneurons.
messages: Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein (By similarity).
messages: Golgi apparatus
messages: nucleolus
messages: nucleoplasm

9031:CXCR5
gene id: 9031:CXCR5
uniprot id: G4U4M4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:ACOX2
gene id: 9031:ACOX2
uniprot id: E1C5V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9031:SRP72
gene id: 9031:SRP72
uniprot id: Q5ZKZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

9031:ATP6V0A1
gene id: 9031:ATP6V0A1
uniprot id: A0A1D5P5R9
uniprot id: Q9I8D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Detected in brain (at protein level). Highest expression in brain, intermediate levels in kidney, and relatively low levels in bone and liver.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Melanosome
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits (By similarity).
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9031:CSF3R
gene id: 9031:CSF3R
uniprot id: E1BQZ9
uniprot id: Q5F3Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9031:SRD5A3
gene id: 9031:SRD5A3
uniprot id: F1NLD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9031:FLT4
gene id: 9031:FLT4
uniprot id: F1N871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane
messages: Nucleus

9031:POU3F1
gene id: 9031:POU3F1
uniprot id: O73861
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9031:DNPEP
gene id: 9031:DNPEP
uniprot id: Q5ZJ47
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

9031:PLCG2
gene id: 9031:PLCG2
uniprot id: A0A1D5PHP4
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9031:BMP3
gene id: 9031:BMP3
uniprot id: Q4FAB3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9031:ZNF326
gene id: 9031:ZNF326
uniprot id: Q5ZJ02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AKAP95 family.
messages: Component of the DBIRD complex.
messages: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing.
messages: Nucleus

9031:KLHL14
gene id: 9031:KLHL14
uniprot id: Q5F3N5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: cytosol

9031:CRYL1
gene id: 9031:CRYL1
uniprot id: F1P156
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9031:DOCK10
gene id: 9031:DOCK10
uniprot id: A0A3Q2UE17
uniprot id: A0A3Q2UEP9
uniprot id: A0A3Q3AYC4
names: Similarity
messages: Belongs to the DOCK family.

9031:LOC101751605
gene id: 9031:LOC101751605
uniprot id: A0A1D5PWE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:NPSR1
gene id: 9031:NPSR1
uniprot id: A0A1D5PKZ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SNX32
gene id: 9031:SNX32
uniprot id: Q5ZK22
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

9031:BTBD10
gene id: 9031:BTBD10
uniprot id: E1C8S4
uniprot id: R4GI02
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ADAM23
gene id: 9031:ADAM23
uniprot id: A0A3Q2U589
uniprot id: A0A3Q2U8D8
uniprot id: A0A3Q2UHH0
uniprot id: B8XA33
uniprot id: F1NYC6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PTBP1
gene id: 9031:PTBP1
uniprot id: A0A1L1S0D8
uniprot id: Q5F456
names: Subcellular Location Annotation
messages: Nucleus

9031:MRPS6
gene id: 9031:MRPS6
uniprot id: Q5ZIJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

9031:LOC100859722
gene id: 9031:LOC100859722
uniprot id: A0A1L1RYD1
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:HN1L
gene id: 9031:HN1L
uniprot id: A0A3S5ZP73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

9031:FMR1
gene id: 9031:FMR1
uniprot id: F1NF19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

9031:PLCD1
gene id: 9031:PLCD1
uniprot id: A0A3Q2TWU3
uniprot id: E1C3D8
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9031:ACTN1
gene id: 9031:ACTN1
uniprot id: A0A1D5P9P3
uniprot id: P05094
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-actinin family.
messages: Cell junction
messages: Cell membrane
messages: F-actin cross-linking protein is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
messages: Homodimer; antiparallel (By similarity). Interacts with PDLIM4 (via PDZ domain) (PubMed:14729062).
messages: Z line
messages: cytoskeleton
messages: ruffle

9031:PTGDS
gene id: 9031:PTGDS
uniprot id: Q8QFM7
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9031:NUP42
gene id: 9031:NUP42
uniprot id: Q5ZI22
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus membrane
messages: Probable component of the nuclear pore complex (NPC).
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
messages: The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.
messages: nuclear pore complex

9031:RABGAP1L
gene id: 9031:RABGAP1L
uniprot id: Q5ZJ17
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Early endosome
messages: GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).
messages: Golgi apparatus
messages: Interacts with ANK2.
messages: The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.

9031:C11orf58
gene id: 9031:C11orf58
uniprot id: Q9I9J6
names: Developmental Stage
names: Similarity
names: Tissue Specificity
messages: Belongs to the SMAP family.
messages: Expressed in brain, heart, eye, liver, kidney and skeletal muscle.
messages: Expressed in embryos at 2, 4 and 6 dpc.

9031:POLR3H
gene id: 9031:POLR3H
uniprot id: E1BV29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

9031:SPSB1
gene id: 9031:SPSB1
uniprot id: E1C5U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9031:FZD2
gene id: 9031:FZD2
uniprot id: Q6WJ01
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:IL1RL1
gene id: 9031:IL1RL1
uniprot id: Q9DEE4
uniprot id: Q9DEE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

9031:FUBP3
gene id: 9031:FUBP3
uniprot id: A0A3Q2TU83
uniprot id: A0A3Q3AB26
uniprot id: Q5ZM76
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ANPEP
gene id: 9031:ANPEP
uniprot id: O57579
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity aminopeptidase. Degrades a variety of peptides possessing various N-terminal amino acids including hydrophobic, basic and acidic amino acids. Preferentially hydrolyzes small peptides consisting of 4 or 5 amino acids. Hydrolyzes the N-terminal Xaa-Pro bonds in the chicken brain peptide Leu-Pro-Leu-Arg-PheNH2, the substance P fragment Arg-Pro-Lys-Pro and the bradykinin fragment Arg-Pro-Pro-Gly-Phe. Hydrolyzes the N-formylated peptides fMet-Leu-Phe, fMet-Ala-Gly-Ser-Glu and fMet-Nle-Leu-Phe-Nle-Tyr-Lys, but does not hydrolyze peptides with acetylation or pyroglutamic acid at N-terminus. Does not hydrolyze large peptides such as complete substance P, bradykinin or schistoFLRFamide.
messages: Cell membrane
messages: Detected in the plasma and granule fractions of egg yolk (at protein level).
messages: Homodimer.

9031:SUSD2
gene id: 9031:SUSD2
uniprot id: A0A3Q2TZY5
uniprot id: E1C3A8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TSSC4
gene id: 9031:TSSC4
uniprot id: F1NV16
uniprot id: Q5ZJS5
names: Similarity
messages: Belongs to the TSSC4 family.

9031:FN1
gene id: 9031:FN1
uniprot id: P11722
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).
messages: Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
messages: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN7 (By similarity).
messages: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix.
messages: Sulfated.
messages: extracellular matrix

9031:IGFBP2
gene id: 9031:IGFBP2
uniprot id: P49705
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: Expressed in embryonic day-15 eye, brain, skeletal muscle, heart and intestine, but virtually absent from embryonic day-15 liver.
messages: Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Secreted
messages: The C-terminus is required for IGF-binding and growth inhibition.

9031:POPDC2
gene id: 9031:POPDC2
uniprot id: Q6TRX0
names: Similarity
messages: Belongs to the popeye family.

9031:ZHX3
gene id: 9031:ZHX3
uniprot id: A0A1D5NUM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9031:FOXF1
gene id: 9031:FOXF1
uniprot id: A0A1D5P6I4
names: Subcellular Location Annotation
messages: Nucleus

9031:THOC7
gene id: 9031:THOC7
uniprot id: F1N915
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

9031:POLR2E
gene id: 9031:POLR2E
uniprot id: F1NHV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

9031:KCTD10
gene id: 9031:KCTD10
uniprot id: F1NW24
names: Similarity
messages: Belongs to the BACURD family.

9031:SHC1
gene id: 9031:SHC1
uniprot id: A0A1D5NYP8
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ATP6V0D1
gene id: 9031:ATP6V0D1
uniprot id: E1BVF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9031:FCER1G
gene id: 9031:FCER1G
uniprot id: A0PFW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9031:MRS2
gene id: 9031:MRS2
uniprot id: A0A1D5P665
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

9031:RBPMS2
gene id: 9031:RBPMS2
uniprot id: Q9W6I1
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in developing heart.
messages: Highly expressed in embryonic stomach, midgut and colon during the period of visceral smooth muscle cell differentiation; levels decrease rapidly thereafter (PubMed:22683258). mRNA already detected at stage 7-8 in the cardiogenic mesoderm, and become almost undetectable in the outer curvature of the ventricular region whereas remaining high in the developing atrial regions (PubMed:10096065).
messages: Homodimer.
messages: RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:22683258, PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway (PubMed:25064856). Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (PubMed:25064856).

9031:LOC100858647
gene id: 9031:LOC100858647
uniprot id: A0A3Q2U3V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9031:SLC15A2
gene id: 9031:SLC15A2
uniprot id: U5TSZ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9031:CARNS1
gene id: 9031:CARNS1
uniprot id: D3KCC4
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.
messages: Homotetramer.

9031:DYRK3
gene id: 9031:DYRK3
uniprot id: F1ND56
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9031:APMAP
gene id: 9031:APMAP
uniprot id: Q5ZIF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the strictosidine synthase family.
messages: Membrane

9031:ERN1
gene id: 9031:ERN1
uniprot id: F1NPU5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:STAT4
gene id: 9031:STAT4
uniprot id: A0A1D5PNV3
uniprot id: Q08I97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9031:LYPLAL1
gene id: 9031:LYPLAL1
uniprot id: A0A3Q2U2T6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9031:FYN
gene id: 9031:FYN
uniprot id: A0A3Q2U639
uniprot id: A0A3Q2UIT4
uniprot id: F1NQU9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:CALM2
gene id: 9031:CALM2
uniprot id: P62149
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

9031:CTNNA2
gene id: 9031:CTNNA2
uniprot id: P30997
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the neural tube, dorsal root glanglia, spinal nerves and myotome at 4 dpc. Expressed in neuronal and glial cell populations as detected at 10 dpc (at protein level).
messages: Interacts with CDH1 and CDH2.
messages: Mainly in the nervous system (at protein level).
messages: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system.
messages: Nucleus
messages: adherens junction
messages: axon
messages: cytoskeleton

9031:NTN4L
gene id: 9031:NTN4L
uniprot id: F1P486
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ARHGAP15
gene id: 9031:ARHGAP15
uniprot id: Q5ZMM3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
messages: Membrane

9031:ATP6AP2
gene id: 9031:ATP6AP2
uniprot id: F1NB42
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

9031:CETN1
gene id: 9031:CETN1
uniprot id: F1NM71
names: Similarity
messages: Belongs to the centrin family.

9031:SPINK5
gene id: 9031:SPINK5
uniprot id: P10184
names: Allergen
names: Biotechnology
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Causes an allergic reaction in humans. Binds to IgE of egg-allergic patients. Immunoreactivity is lost by simulated gastric and gastroduodenal digestion (PubMed:23122126). Binds to rabbit anti-ovomucoid IgG antibody indicating the cross-reactivity between this protein and the ovomucoid protein from egg white (PubMed:6838526).
messages: Expressed in liver of pre-laying and egg-laying hens throughout sexual maturation. Expression increases gradually from 13 weeks of age reaching its maximum at 15 weeks of age (pre-laying hens). A significant decrease in expression is observed in 41-week-old hens (egg-laying), a level that is significantly lower than that measured initially in 13-week-old pullets.
messages: Expressed in oviduct (at protein level) (PubMed:3571241). Expressed in egg white (at protein level) (PubMed:6838526, PubMed:14519973, PubMed:23122126, PubMed:25436390). Expressed in egg yolk plasma of non-fertilized eggs (at protein level) (PubMed:22010862). Expressed in the magnum of the oviduct (at protein level) (PubMed:25436390). Expressed in oviduct (PubMed:3571241, PubMed:14609095). Expressed in liver (PubMed:3571241, PubMed:11572089, PubMed:22010862). Expressed in the cortico-medullary border region of the bursa of Fabricius by the bursal secretory dendritic-like cells (PubMed:15252730). Highly expressed in the magnum of the oviduct, and at a lower level in uterus. Weakly expressed in white isthmus and very weakly in infundibulum. Not expressed in duodenum and kidney (PubMed:22010862).
messages: Expression is regulated by dietary stress. Significantly increased expression between days 0 to 5 in egg whites of eggs laid by corticosterone-fed hens (at protein level). Decreased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens (PubMed:25436390). Significantly increased expression by estrogen. Rapidly up-regulated within 0.5 hour after extrogen exposure with a peak at 1-4 hours and diminishing thereafter (PubMed:11572089). Up-regulated during sexual maturation of pullets (PubMed:22010862).
messages: Glycosylated.
messages: Prevents symptomatic gastoroenteritis in vivo in a mouse model of rotavirus infection. Significantly inhibits intestinal replication of EDIM strain of murine rotavirus in infant mice up to 4 days after intragastrical administration of the virus.
messages: Secreted
messages: Seems to have at least five separate non-overlapping active inhibitory domains; two for trypsin, two for chymotrypsin and one for elastase. They can be bound to the domains simultaneously.
messages: Serine protease inhibitor involved in antimicrobial egg defense preventing contamination of table eggs (non-fertilized eggs) and protecting the chick embryo (fertilized eggs) (Probable). Inhibits trypsin, chymotrypsin, elastase, subtilisin and a proteinase of fungus Aspergillus oryzae (PubMed:13944692, PubMed:6904299, PubMed:6838526, PubMed:14519973, PubMed:14609095, PubMed:22010862). Inhibits calcium-activated potassium channels KCNMA1 (bovine) and slo (Drosophila) (PubMed:8973172). Has antibacterial activity against B.thuringiensis LMSA 3.06.004, but not against S.aureus CIP 103 811, P.aeruginosa PAO1, B.cereus ATCC6464 or B.subtilis ATCC 6633 (PubMed:22010862).
messages: The galactomannan conjugate of this protein prepared through the Maillard reaction shows almost the same inhibitory activity toward trypsin, chymotrypsin and elastase, with stronger heat and emulsion stability, and better emulsifying properties than the untreated protein. The conjugate can therefore be useful for industrial application.

9031:ANP32B
gene id: 9031:ANP32B
uniprot id: Q5ZMN0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ANP32 family.
messages: Directly cleaved by caspase-3/CASP3.
messages: Histone binding is mediated by the concave surface of the LRR region.
messages: Interacts with histones H3 and H4. Interacts with KLF5; this interaction induces promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B.
messages: Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis. Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes. Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1.
messages: Nucleus

9031:TBCK
gene id: 9031:TBCK
uniprot id: Q5F361
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Cytoplasm
messages: Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization.
messages: Midbody
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: spindle

9031:HSPE1
gene id: 9031:HSPE1
uniprot id: O42283
names: Similarity
messages: Belongs to the GroES chaperonin family.

9031:ERCC4
gene id: 9031:ERCC4
uniprot id: V5Y0M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9031:SH3GLB2
gene id: 9031:SH3GLB2
uniprot id: Q5ZJ81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with SH3GLB1.

9031:SLC4A2
gene id: 9031:SLC4A2
uniprot id: Q90710
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane
messages: Plasma membrane anion exchange protein of wide distribution.

9031:NIPSNAP3A
gene id: 9031:NIPSNAP3A
uniprot id: R4GJL1
names: Similarity
messages: Belongs to the NipSnap family.

9031:EPHX1
gene id: 9031:EPHX1
uniprot id: F1P4R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:IFI27L2
gene id: 9031:IFI27L2
uniprot id: Q6IEC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9031:TNFAIP6
gene id: 9031:TNFAIP6
uniprot id: Q155F6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:IMMP1L
gene id: 9031:IMMP1L
uniprot id: F1P533
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

9031:ECE1
gene id: 9031:ECE1
uniprot id: Q9DGN6
names: Function
messages: Converts big endothelin-1 to endothelin-1.

9031:STAM2
gene id: 9031:STAM2
uniprot id: O93436
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the STAM family.
messages: Component of the ESCRT-0 complex composed of STAM2 and HGS.
messages: Cytoplasm
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
messages: Phosphorylated in response to EGF and PDGF. Phosphorylated by SRC.
messages: Ubiquitously expressed.

9031:TNNT3
gene id: 9031:TNNT3
uniprot id: O57559
uniprot id: P12620
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9031:FGF3
gene id: 9031:FGF3
uniprot id: P48801
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.
messages: Secreted

9031:EML6
gene id: 9031:EML6
uniprot id: A0A1D5PMQ4
uniprot id: E1BZK6
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

9031:CER1
gene id: 9031:CER1
uniprot id: Q9PUK2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:DNMT3A
gene id: 9031:DNMT3A
uniprot id: A0A1D5NTR2
uniprot id: Q4W5Z4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Chromosome
messages: Cytoplasm
messages: Nucleus
messages: Required for genome-wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity. Also has weak auto-methylation activity on some Cys residue in absence of DNA.
messages: The PWWP domain is essential for targeting to pericentric heterochromatin.

9031:FGR
gene id: 9031:FGR
uniprot id: Q02977
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: May participate in signaling pathways.
messages: Phosphorylated.
messages: There are elevated levels of this protein in neural and hematopoietic tissues.

9031:NR1D2
gene id: 9031:NR1D2
uniprot id: A0A1D6UPS4
uniprot id: Q90970
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:ADSS2
gene id: 9031:ADSS2
uniprot id: Q5ZJL5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Inhibited competitively by AMP and IMP and non-competitively by fructose 1,6-bisphosphate.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

9031:NBR1
gene id: 9031:NBR1
uniprot id: E1C6F8
names: Subcellular Location Annotation
messages: autophagosome

9031:GUCY1A2
gene id: 9031:GUCY1A2
uniprot id: E1C0P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

9031:ATP8B4
gene id: 9031:ATP8B4
uniprot id: E1BVN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:ART7C
gene id: 9031:ART7C
uniprot id: A9NJ60
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:LOC431324
gene id: 9031:LOC431324
uniprot id: A0A1D5P9R9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:RGN
gene id: 9031:RGN
uniprot id: F1NBX1
uniprot id: Q9I923
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).
messages: Cytoplasm
messages: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).

9031:CHMP5
gene id: 9031:CHMP5
uniprot id: E1BSI4
names: Similarity
messages: Belongs to the SNF7 family.

9031:MLST8
gene id: 9031:MLST8
uniprot id: F1NAZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of TORC1 complex. Part of the TORC2 complex.
messages: Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals.

9031:TMEM30A
gene id: 9031:TMEM30A
uniprot id: Q5F362
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes (By similarity).
messages: Apical cell membrane
messages: Belongs to the CDC50/LEM3 family.
messages: Component of various P4-ATPase flippase complexes which consists of a catalytic alpha subunit and an accessory beta subunit.
messages: Golgi apparatus
messages: Membrane
messages: Photoreceptor inner segment
messages: The N-terminal domain seems to play a role in the reaction cycle of the catalytic subunit such as ATP8A2.
messages: photoreceptor outer segment
messages: secretory vesicle membrane

9031:ANO3
gene id: 9031:ANO3
uniprot id: A0A3Q2U5U2
uniprot id: A0A3Q2UGS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

9031:TMEM170A
gene id: 9031:TMEM170A
uniprot id: F1N8V4
uniprot id: Q5ZM31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Endoplasmic reticulum membrane
messages: May regulate membrane morphogenesis in the endoplasmic reticulum (ER) by promoting ER sheet formation at the expense of ER tubules.
messages: Membrane
messages: Nucleus envelope

9031:LOC420039
gene id: 9031:LOC420039
uniprot id: A0A1D5PMQ5
names: Similarity
messages: Belongs to the intermediate filament family.

9031:AP3B1
gene id: 9031:AP3B1
uniprot id: A0A1D5PAF9
uniprot id: E1BW97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

9031:AGPAT4
gene id: 9031:AGPAT4
uniprot id: E1BY49
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9031:ADAMTS15
gene id: 9031:ADAMTS15
uniprot id: E1BX45
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:PPIB
gene id: 9031:PPIB
uniprot id: P24367
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
messages: Endoplasmic reticulum lumen
messages: Inhibited by cyclosporin A (CsA).
messages: Melanosome
messages: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

9031:CD28
gene id: 9031:CD28
uniprot id: P31043
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Monomer.
messages: Possibly involved in T-cell activation.

9031:GR42L5
gene id: 9031:GR42L5
uniprot id: I3RLD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:MEOX1
gene id: 9031:MEOX1
uniprot id: Q9YI38
names: Subcellular Location Annotation
messages: Nucleus

9031:HNF1A
gene id: 9031:HNF1A
uniprot id: A0A1L1RPG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

9031:PPA2
gene id: 9031:PPA2
uniprot id: A0A1D5PM39
uniprot id: E1C6X1
names: Similarity
messages: Belongs to the PPase family.

9031:LOC420807
gene id: 9031:LOC420807
uniprot id: A0A1D5PWR3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9031:PTPRG
gene id: 9031:PTPRG
uniprot id: A0A1D5NTM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

9031:LOC418108
gene id: 9031:LOC418108
uniprot id: A0A1D5PRH8
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:SULT1B
gene id: 9031:SULT1B
uniprot id: F1NMA3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:RPL13
gene id: 9031:RPL13
uniprot id: P41125
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL13 family.
messages: Component of the 60S large ribosomal subunit (LSU).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs.
messages: Cytoplasm

9031:LMNB1
gene id: 9031:LMNB1
uniprot id: P14731
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Homodimer. Interacts with lamin-associated polypeptides IA, IB and 2.
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
messages: Nucleus lamina
messages: Phosphorylated. Phosphorylation is increased before envelope disintegration and probably plays a role in regulating lamin associations (By similarity).
messages: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.

9031:PMP22
gene id: 9031:PMP22
uniprot id: A0A1D5PDJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

9031:CCT4
gene id: 9031:CCT4
uniprot id: Q9I8D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9031:ARHGEF12
gene id: 9031:ARHGEF12
uniprot id: A0A1D5PUV1
uniprot id: F1P1Y1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

9031:PLXNB3
gene id: 9031:PLXNB3
uniprot id: E1BWU6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:GDF6
gene id: 9031:GDF6
uniprot id: A0A1D5P0D7
names: Similarity
messages: Belongs to the TGF-beta family.

9031:MID1IP1
gene id: 9031:MID1IP1
uniprot id: Q6Q123
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

9031:B4GALT7
gene id: 9031:B4GALT7
uniprot id: Q2HPN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:SLC16A9
gene id: 9031:SLC16A9
uniprot id: Q5ZJU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity).

9031:CASP3
gene id: 9031:CASP3
uniprot id: O93417
names: Similarity
messages: Belongs to the peptidase C14A family.

9031:DIPK2A
gene id: 9031:DIPK2A
uniprot id: A0A3Q2U652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9031:FOXG1
gene id: 9031:FOXG1
uniprot id: Q90964
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Can be detected in regions including primordial retina and neuroepithelium by embryonic day 2 (2dpc). At 3 dpc, expressed in the nasal retina and pigment epithelium as well as in the telencephalon, and at 7 dpc is expressed in retinal ganglion cells. Levels begin to decline from 4 dpc and almost disappear by 10 dpc.
messages: May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.
messages: Nucleus
messages: Retina and brain.

9031:PMS1
gene id: 9031:PMS1
uniprot id: A0A1D5NZ03
uniprot id: Q5ZKT5
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9031:DDX47
gene id: 9031:DDX47
uniprot id: Q5ZLB0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9031:CYBC1
gene id: 9031:CYBC1
uniprot id: E1BYV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:CITED2
gene id: 9031:CITED2
uniprot id: Q9DDW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9031:AFG3L2
gene id: 9031:AFG3L2
uniprot id: E1BZ74
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9031:ADAM17
gene id: 9031:ADAM17
uniprot id: Q5ZL93
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:CRHBP
gene id: 9031:CRHBP
uniprot id: E1C1R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9031:SMUG1
gene id: 9031:SMUG1
uniprot id: A0A3Q3AR14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

9031:MYLK2
gene id: 9031:MYLK2
uniprot id: A2NBE2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May interact with centrin.

9031:DUT
gene id: 9031:DUT
uniprot id: A0A1L1RY20
uniprot id: Q5ZKJ3
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

9031:CREB5
gene id: 9031:CREB5
uniprot id: A0A3Q2UBL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9031:SLC24A1
gene id: 9031:SLC24A1
uniprot id: Q9IAL8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:10662833). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (By similarity).
messages: Cell membrane
messages: Retinal rods. Localizes to the inner segment of rod photoreceptors.
messages: The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration and topology.

9031:LCOR
gene id: 9031:LCOR
uniprot id: F1NKP5
names: Subcellular Location Annotation
messages: Nucleus

9031:CENPS
gene id: 9031:CENPS
uniprot id: E1BSW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (By similarity).
messages: Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners. MHF heterodimers can assemble to form tetrameric structures (PubMed:22304917). MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex (PubMed:22304917). Forms a discrete complex with FANCM and CENPX, called FANCM-MHF; this interaction, probably mediated by direct binding between CENPS and FANCM, leads to synergistic activation of double-stranded DNA binding and strongly stimulates FANCM-mediated DNA remodeling. Recruited by FANCM to the Fanconi anemia (FA) core complex, which consists of CENPS, CENPX, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FAAP24 and FAAP100. The FA core complex associates with Bloom syndrome (BLM) complex, which consists of at least BLM, DNA topoisomerase 3-alpha (TOP3A), RMI1/BLAP75, RPA1/RPA70 and RPA2/RPA32. The super complex between FA and BLM is called BRAFT. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).
messages: Nucleus
messages: centromere
messages: kinetochore

9031:ATAD1
gene id: 9031:ATAD1
uniprot id: F1NT80
names: Similarity
messages: Belongs to the AAA ATPase family.

9031:S1PR4
gene id: 9031:S1PR4
uniprot id: H9L025
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:CHRNA2
gene id: 9031:CHRNA2
uniprot id: P09480
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily.
messages: Cell membrane
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains.
messages: Postsynaptic cell membrane

9031:TMEM38B
gene id: 9031:TMEM38B
uniprot id: R4GGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9031:MTNR1A
gene id: 9031:MTNR1A
uniprot id: P49285
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in optic tectum and retina, less in neostriatum, hypothalamus and thalamus.
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).

9031:PDGFA
gene id: 9031:PDGFA
uniprot id: Q90WK1
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9031:HIST1H2A4L2
gene id: 9031:HIST1H2A4L2
uniprot id: P02263
uniprot id: Q92069
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AK119Ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties, leading to the recruitment of repair proteins to sites of DNA damage. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:PTPRU
gene id: 9031:PTPRU
uniprot id: Q6YI48
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Cell junction
messages: Cell membrane
messages: Contaminating sequence. Sequence of unknown origin.
messages: First observed at HH4 in mesodermal progenitor cells surrounding the area of Hensen node and in the primitive streak. Expressed in the presomitic mesoderm and dynamically expressed in forming somites. Detected in the developing intermediate mesoderm at HH9 and in the mesonephric tubules and ducts by stage HH18. Expressed in the developing nervous system. Also observed in the limb bud and the developing heart.
messages: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity (By similarity).

9031:HMGN2P46
gene id: 9031:HMGN2P46
uniprot id: Q5ZIR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9031:DLG1
gene id: 9031:DLG1
uniprot id: A0A1D5P1S9
uniprot id: A0A1D5PT29
uniprot id: A0A3Q2TXA3
uniprot id: E1BT38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

9031:ACSM3
gene id: 9031:ACSM3
uniprot id: A0A3Q3AJN3
uniprot id: F1NVA1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9031:HSD17B1
gene id: 9031:HSD17B1
uniprot id: O12968
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:PRKCD
gene id: 9031:PRKCD
uniprot id: A0A1D5PXN4
uniprot id: Q5ZKE2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

9031:SLC45A3
gene id: 9031:SLC45A3
uniprot id: E1C3K1
names: Subcellular Location Annotation
messages: Membrane

9031:CHRM3
gene id: 9031:CHRM3
uniprot id: P49578
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
messages: Brain, heart atria, and ventricle.
messages: Cell membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9031:LPAR4
gene id: 9031:LPAR4
uniprot id: E1BWJ9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:GPR137C
gene id: 9031:GPR137C
uniprot id: F1NU49
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9031:AKAP1
gene id: 9031:AKAP1
uniprot id: E1C1N8
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ETF1
gene id: 9031:ETF1
uniprot id: A0A1L1RX26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9031:ATP5J
gene id: 9031:ATP5J
uniprot id: E1C4V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9031:SDC3
gene id: 9031:SDC3
uniprot id: P26261
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan that may bear both heparan sulfate and chondroitin sulfate. The multiple functional domains provide potential sites for mediating the adhesive cell-matrix interactions and cytoskeletal reorganization involved in limb chondrogenesis. Interaction with other matrix ligands as well as phosphorylation and shedding of the ectodomain might be involved in cell shape changes that occur during chondrogenesis. Furthermore, shedding of the ectodomain might break the adhesive interactions that promoted condensation, thus facilitating the deposition of cartilage matrix molecules.
messages: Expressed in high amounts at the onset of limb cartilage differentiation.
messages: Membrane
messages: O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules.
messages: Proximal chondrogenic central core of embryonic limb buds where cartilage differentiation is being initiated.

9031:CDC42BPA
gene id: 9031:CDC42BPA
uniprot id: E1BWT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: lamellipodium

9031:TMEM150B
gene id: 9031:TMEM150B
uniprot id: E1C9H3
names: Subcellular Location Annotation
messages: Membrane

9031:NR2C1
gene id: 9031:NR2C1
uniprot id: Q8JID3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:LOC769491
gene id: 9031:LOC769491
uniprot id: A0A1D5PS82
uniprot id: R4GLN9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:ROCK2
gene id: 9031:ROCK2
uniprot id: A0A1D5NWB8
uniprot id: A0A3Q2TTH6
uniprot id: F1NK88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: centrosome

9031:RGS9BP
gene id: 9031:RGS9BP
uniprot id: Q6XK22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RGS7BP/RGS9BP family.
messages: Expressed in a variety of neuronal tissues, particularly in sensory cells including inner ear hair cells, photoreceptors and dorsal root ganglion neurons.
messages: Membrane
messages: Regulator of G protein-coupled receptor (GPCR) signaling. Probably acts by regulating the activity of some 'R7' family protein (RGS6, RGS7, RGS9 and/or RGS11).

9031:PDK1
gene id: 9031:PDK1
uniprot id: F1NLP2
uniprot id: Q5ZLT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9031:GALR2
gene id: 9031:GALR2
uniprot id: B2CL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:SLC25A4
gene id: 9031:SLC25A4
uniprot id: Q5ZMJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9031:PLS1
gene id: 9031:PLS1
uniprot id: P19179
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminus is blocked.
messages: stereocilium

9031:ACAA1
gene id: 9031:ACAA1
uniprot id: F1NB64
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9031:DEDD
gene id: 9031:DEDD
uniprot id: A0A1D5PXF2
names: Subcellular Location Annotation
messages: nucleolus

9031:GAREM1
gene id: 9031:GAREM1
uniprot id: A0A3Q2UK26
names: Similarity
messages: Belongs to the GAREM family.

9031:SEH1L
gene id: 9031:SEH1L
uniprot id: A0A1D5NZU0
uniprot id: A0A1L1RKI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9031:ATOH7
gene id: 9031:ATOH7
uniprot id: O57598
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expressed in the developing retina, and in a tiny population of ventricular cells located in the ventral domain of the spinal cord and hindbrain. Retinal expression peaks at stage 29 (6 dpc).
messages: Nucleus
messages: Perikaryon
messages: The basic motif confers specificity for the CHRNB3 promoter.
messages: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract (PubMed:11124117, PubMed:15342472, PubMed:16260616). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity). During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3 (PubMed:11172005).
messages: Up-regulated by NGN2 and ATOH7. Down-regulated by HES1.
messages: axon

9031:LCORL
gene id: 9031:LCORL
uniprot id: Q5ZJK5
names: Function
names: Subcellular Location Annotation
messages: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'.
messages: Nucleus

9031:MTRF1L
gene id: 9031:MTRF1L
uniprot id: F1NW58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9031:CAT
gene id: 9031:CAT
uniprot id: Q5ZMM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9031:ACTR3
gene id: 9031:ACTR3
uniprot id: Q90WD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the actin family. ARP3 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
messages: Detected in fibroblasts.
messages: Nucleus
messages: cytoskeleton

9031:KIF3B
gene id: 9031:KIF3B
uniprot id: Q5F423
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:PIGM
gene id: 9031:PIGM
uniprot id: F1NE39
uniprot id: Q5F380
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity).
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9031:MYL4
gene id: 9031:MYL4
uniprot id: P09540
names: Miscellaneous
names: Subunit
messages: Light chain 23 is expressed in chicken embryonic skeletal, cardiac, smooth muscles and in brain continuously from embryo to adult.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.

9031:COPG2
gene id: 9031:COPG2
uniprot id: A0A1D5PLX0
uniprot id: A0A1L1RZW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9031:NOTCH1
gene id: 9031:NOTCH1
uniprot id: A0A3Q2ULK6
uniprot id: F1NZ70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9031:CRYZ
gene id: 9031:CRYZ
uniprot id: F1P4I0
uniprot id: Q5ZHT3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9031:RIC8A
gene id: 9031:RIC8A
uniprot id: Q5ZL77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma (By similarity).

9031:ELF3
gene id: 9031:ELF3
uniprot id: E1C6L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:ATP2B1
gene id: 9031:ATP2B1
uniprot id: A0A1D5PFN0
uniprot id: A0A1D5PXJ7
uniprot id: Q98SH2
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: By vitamin D and 1,25-dihydroxyvitamin D3, and by calcium and phosphorous deficiency.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:CLTA
gene id: 9031:CLTA
uniprot id: A0A3Q2TVE4
uniprot id: A0A3Q2U5N2
uniprot id: Q5ZHR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9031:CPNE2
gene id: 9031:CPNE2
uniprot id: A0A3Q2U7U5
uniprot id: E1BQ84
names: Similarity
messages: Belongs to the copine family.

9031:ITIH5
gene id: 9031:ITIH5
uniprot id: E1BTM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9031:HTR7L
gene id: 9031:HTR7L
uniprot id: D2XUT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:TMEM131L
gene id: 9031:TMEM131L
uniprot id: A0A3Q2UAH6
names: Similarity
messages: Belongs to the TMEM131 family.

9031:GAD2
gene id: 9031:GAD2
uniprot id: A0A1D5PLC8
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9031:SLIT2
gene id: 9031:SLIT2
uniprot id: A0A1D5P0S9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:LOC420291
gene id: 9031:LOC420291
uniprot id: A0A1D5P312
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:YAE1D1
gene id: 9031:YAE1D1
uniprot id: A0A1D5PWD6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:HSPB8
gene id: 9031:HSPB8
uniprot id: E1C6V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.

9031:MVK
gene id: 9031:MVK
uniprot id: E1BZ79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

9031:P2RY6
gene id: 9031:P2RY6
uniprot id: Q98907
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9031:ZDHHC4
gene id: 9031:ZDHHC4
uniprot id: E1C0F2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:VTG2
gene id: 9031:VTG2
uniprot id: P02845
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Tissue Specificity
messages: After incorporation from serum via a specific receptor, it is cleaved into four fragments, heavy and light chain lipovitellins, phosphovitin and YGP40, and YGP40 is released into the yolk plasma before or during compartmentation of lipovitellin-phosvitin complex into the yolk granule.
messages: By steroids (estrogen).
messages: Cathepsin D is responsible for intraoocytic processing of vitellogenin.
messages: May contain intrachain disulfide bonds.
messages: Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo.
messages: Phosvitin, an egg yolk storage protein, is one of the most highly phosphorylated (10%) proteins in nature.
messages: Precursor of the major egg-yolk proteins that are sources of nutrients during early development of oviparous organisms.
messages: Vitellogenin II is the most abundant of the three vitellogenins (I, II, and III).

9031:TYRP1
gene id: 9031:TYRP1
uniprot id: F1NXQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane
messages: Membrane

9031:SLC22A3
gene id: 9031:SLC22A3
uniprot id: E1BXN3
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9031:NETO2
gene id: 9031:NETO2
uniprot id: A0A1D5P8L8
uniprot id: A0A3Q2TU94
uniprot id: E1BYZ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GOT1
gene id: 9031:GOT1
uniprot id: P00504
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
messages: Cytoplasm
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9031:TUBA5
gene id: 9031:TUBA5
uniprot id: A0A1D5PAR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:FYTTD1
gene id: 9031:FYTTD1
uniprot id: Q5ZJ20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore (By similarity).
messages: Widely expressed.
messages: nucleoplasm

9031:BIVM
gene id: 9031:BIVM
uniprot id: A0A140T8H3
names: Similarity
messages: Belongs to the BIVM family.

9031:ALG5
gene id: 9031:ALG5
uniprot id: E1BUU9
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9031:TEF
gene id: 9031:TEF
uniprot id: Q92172
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. PAR subfamily.
messages: Binds DNA as a homodimer or a heterodimer. Exists as a stable dimer in the absence of DNA.
messages: Isoform 1 and isoform 3 are expressed in a variety of somatic tissues, including liver, heart, intestine, stomach and kidney. Both isoforms are also expressed in hepatoma (LMH) cells and in embryonic fibroblast cell lines. Isoform 2 and isoform 4 are expressed in adult heart and intestine.
messages: Isoform 3 is expressed as early as embryonic day 10.
messages: Nucleus
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform 1.
messages: Produced by alternative splicing of isoform 2.
messages: Transcription factor that binds to and transactivates the vitellogenin II (VTG2) promoter. Binds to the palindromic sequence 5'-GTTTACATAAAC-3'.

9031:PPIA
gene id: 9031:PPIA
uniprot id: D0EKR3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9031:OGN
gene id: 9031:OGN
uniprot id: Q9W6H0
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: Levels decrease at each developmental time point and further decrease during maturation into adulthood.
messages: The composition of the N-linked chains or the substitution of the N-linked sites is different between embryonic and adult tissues.
messages: extracellular matrix

9031:SYNDIG1L
gene id: 9031:SYNDIG1L
uniprot id: E1BZT0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9031:CSNK1A1
gene id: 9031:CSNK1A1
uniprot id: F1NL64
uniprot id: P67962
uniprot id: Q71UZ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly.
messages: Cytoplasm
messages: Nucleus speckle
messages: centrosome
messages: cilium basal body
messages: kinetochore
messages: spindle

9031:LOC423222
gene id: 9031:LOC423222
uniprot id: A0A3Q2UML3
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9031:CACNG4
gene id: 9031:CACNG4
uniprot id: Q90X18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

9031:BHLHE22
gene id: 9031:BHLHE22
uniprot id: Q71T09
names: Function
names: Subcellular Location Annotation
messages: May act as a transcriptional repressor.
messages: Nucleus

9031:NAA38
gene id: 9031:NAA38
uniprot id: A0A1L1RTB6
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

9031:CDC73
gene id: 9031:CDC73
uniprot id: Q5ZLM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC73 family.
messages: Component of the PAF1 complex, which at least consists of CDC73, PAF1, LEO1, CTR9 and RTF1.
messages: Nucleus
messages: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).

9031:PRPF38B
gene id: 9031:PRPF38B
uniprot id: E1BVP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9031:ST6GALNAC2
gene id: 9031:ST6GALNAC2
uniprot id: Q92184
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundantly expressed at all embryonic stages but not present in adult tissues.
messages: Belongs to the glycosyltransferase 29 family.
messages: Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed:8034663). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed:8034663).
messages: Golgi apparatus membrane
messages: Heart, kidney, testes, brain, liver and lung.

9031:CDC42EP3
gene id: 9031:CDC42EP3
uniprot id: E1C7B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9031:ATP13A2
gene id: 9031:ATP13A2
uniprot id: A0A1D5PJ96
uniprot id: A0A3Q2TYV0
uniprot id: Q5F3F1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:TMED7
gene id: 9031:TMED7
uniprot id: Q5ZLF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9031:LOC100858100
gene id: 9031:LOC100858100
uniprot id: A0A1D5PF73
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:FGFR1OP2
gene id: 9031:FGFR1OP2
uniprot id: Q5ZKJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIKE family.
messages: Cytoplasm

9031:GOLPH3L
gene id: 9031:GOLPH3L
uniprot id: A0A1D5PLP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9031:LUM
gene id: 9031:LUM
uniprot id: P51890
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds keratan sulfate chains.
messages: Binds to laminin.
messages: Cornea and other tissues.
messages: extracellular matrix

9031:CDK2AP1
gene id: 9031:CDK2AP1
uniprot id: A0A1D5PQL4
uniprot id: Q5ZMM0
names: Similarity
messages: Belongs to the CDK2AP family.

9031:PPP2R5C
gene id: 9031:PPP2R5C
uniprot id: Q5F3C6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

9031:GDF2
gene id: 9031:GDF2
uniprot id: P34822
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Appears to regulate cell differentiation within the neural tube. May regulate the differentiation of cell types along the dorsoventral axis of the neural tube, acting in conjunction with distinct ventralizing signals from the notochord and floor plate. Controls the cell differentiation in the neural tube in several ways: (1) promotes the differentiation of cell types that derive from the dorsal neural tube. (2) ensures that the dorsal neural tube is refractory to ventralizing species from the notochord. (3) can diffuse and influence the fate of cells in more ventral regions of the neural tube.
messages: Belongs to the TGF-beta family.
messages: Expressed selectively in the dorsal neural tube. Lower levels seen in kidney and myotomal cells.
messages: Homodimer; disulfide-linked.
messages: Is not expressed in neural cells at stages before neural tube closure. Is expressed at high levels in the dorsal third of the neural tube, beginning at the time of neural tube closure, but not by ventral neural cells or by nonneural cells. Dorsal restriction persists in the spinal cord at stages after the onset of neuronal differentiation. At later stages of spinal development, is restricted to the dorsomedial region of the spinal cord, including but not confined to the roof plate.
messages: Secreted

9031:BYSL
gene id: 9031:BYSL
uniprot id: F1NPV8
names: Similarity
messages: Belongs to the bystin family.

9031:AUH
gene id: 9031:AUH
uniprot id: A0A3Q2U419
uniprot id: E1BTQ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9031:NCBP3
gene id: 9031:NCBP3
uniprot id: Q5ZM19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.
messages: Belongs to the NCBP3 family.
messages: Component of an alternative cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3.
messages: Cytoplasm
messages: Nucleus

9031:SMIM8
gene id: 9031:SMIM8
uniprot id: F1P1R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9031:GAPDH
gene id: 9031:GAPDH
uniprot id: P00356
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
messages: Homotetramer.
messages: Nucleus
messages: S-nitrosylation of Cys-150 leads to translocation to the nucleus.
messages: cytoskeleton
messages: cytosol

9031:PGGHG
gene id: 9031:PGGHG
uniprot id: F1NZI4
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.
messages: Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.

9031:BLMH
gene id: 9031:BLMH
uniprot id: P87362
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm
messages: Homooctamer.
messages: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.

9031:APOB
gene id: 9031:APOB
uniprot id: Q197X2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:IRAK2
gene id: 9031:IRAK2
uniprot id: A0A3Q2UCU7
uniprot id: Q5F382
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

9031:EXFABP
gene id: 9031:EXFABP
uniprot id: P21760
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Developmentally regulated in chick embryo.
messages: Does not seem to be glycosylated.
messages: Down-regulated by dietary stress. Significantly decreased expression between days 0 to 5 in egg whites of eggs laid by corticosterone-fed hens (at protein level). Decreased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens.
messages: Expressed in egg white (at protein level). Expressed in the magnum of the oviduct (at protein level) (PubMed:25436390). Preferentially synthesized in nonproliferating cells.
messages: Monomer.
messages: Secreted
messages: Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.

9031:LMBR1
gene id: 9031:LMBR1
uniprot id: Q7ZUA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the LIMR family.
messages: Detected ubiquitously at low levels throughout the developing embryo. Present initially in the limb mesoderm as the limb bud emerges from the body wall and up-regulated along the posterior margin of the developing limb bud with progression of the limb outgrowth. Higher levels are detected in limb buds, otic vesicles and pharyngeal arches. Isoform 1 is detected in lung, spleen, heart, breast muscle, cartilage and liver of the adult tissues. Isoform 3 is detected in adult lung, spleen, heart and breast muscle but not detected in cartilage and liver.
messages: Membrane
messages: Putative membrane receptor.

9031:HMGB3
gene id: 9031:HMGB3
uniprot id: P40618
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome
messages: Cytoplasm
messages: Found in newly hatched chick liver and decreases during postnatal development.
messages: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Binds to the delta-1 crystallin/ASL1 enhancer (PubMed:7904558). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity).
messages: Nucleus
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-104 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB3 (HMGB3C23hC45hC104h), 2- disulfide HMGB3 (HMGB3C23-C45C104h) and 3- sulfonyl HMGB3 (HMGB3C23soC45soC104so).

9031:ASMT
gene id: 9031:ASMT
uniprot id: Q92056
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
messages: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
messages: Expressed in pineal gland and retina.
messages: Homodimer.

9031:MTMR7
gene id: 9031:MTMR7
uniprot id: A0A1D5PLM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9031:TRPV6
gene id: 9031:TRPV6
uniprot id: F1NAX8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TBC1D24L
gene id: 9031:TBC1D24L
uniprot id: F1P0C6
names: Subcellular Location Annotation
messages: Membrane

9031:BRINP2
gene id: 9031:BRINP2
uniprot id: E1BV99
names: Similarity
messages: Belongs to the BRINP family.

9031:PLPP1
gene id: 9031:PLPP1
uniprot id: A0A1D5NZW4
uniprot id: F1N992
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

9031:CDH22
gene id: 9031:CDH22
uniprot id: E1C3A7
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9031:TMED6
gene id: 9031:TMED6
uniprot id: F1NSJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:TM2D3
gene id: 9031:TM2D3
uniprot id: F1NX03
names: Subcellular Location Annotation
messages: Membrane

9031:GABARAPL2
gene id: 9031:GABARAPL2
uniprot id: A0A3Q2TZN9
names: Similarity
messages: Belongs to the ATG8 family.

9031:GPC5
gene id: 9031:GPC5
uniprot id: A0A1D5NXW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

9031:QKI
gene id: 9031:QKI
uniprot id: F1NWV0
uniprot id: Q9YH18
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer. Does not require RNA to homodimerize (By similarity).
messages: Major isoform.
messages: Nucleus
messages: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity).

9031:LOC768760
gene id: 9031:LOC768760
uniprot id: B0Z662
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9031:MRPL32
gene id: 9031:MRPL32
uniprot id: A0A1D5PFM8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9031:ARHGAP19
gene id: 9031:ARHGAP19
uniprot id: Q5F3G0
names: Function
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

9031:CD3D
gene id: 9031:CD3D
uniprot id: Q90768
names: Subcellular Location Annotation
messages: Membrane

9031:PRIM2
gene id: 9031:PRIM2
uniprot id: Q5ZM06
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

9031:ALDOC
gene id: 9031:ALDOC
uniprot id: R4GM10
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9031:ABCG2
gene id: 9031:ABCG2
uniprot id: E1C5B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

9031:C21orf91
gene id: 9031:C21orf91
uniprot id: Q9I8W6
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the EURL family.
messages: Expressed in undifferentiated retina and lens (PubMed:12815627).
messages: Plays a role in cortical progenitor cell proliferation and differentiation. May promote dendritic spine development of post-migratory cortical projection neurons by modulating the beta-catenin signaling pathway.

9031:HNMT
gene id: 9031:HNMT
uniprot id: E1C378
names: Subunit
messages: Monomer.

9031:RMI2
gene id: 9031:RMI2
uniprot id: Q5ZM20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMI2 family.
messages: Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM (By similarity).
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
messages: Nucleus

9031:IMPG2
gene id: 9031:IMPG2
uniprot id: Q1XI86
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix.
messages: Detected in retina at 12 dpc with increased expression up to a peak at 16 dpc.
messages: Expressed in retina.
messages: Highly glycosylated (N- and O-linked carbohydrates).
messages: Photoreceptor inner segment membrane
messages: Photoreceptor outer segment membrane
messages: interphotoreceptor matrix

9031:CCR8L
gene id: 9031:CCR8L
uniprot id: Q702H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9031:USP48
gene id: 9031:USP48
uniprot id: Q5ZM45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus
messages: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

9031:SCOC
gene id: 9031:SCOC
uniprot id: A0A3Q2TT83
uniprot id: B0LHV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9031:GRB2
gene id: 9031:GRB2
uniprot id: A3R0S3
uniprot id: Q07883
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
messages: Associates with activated Tyr-phosphorylated EGF receptors and PDGF receptors via its SH2 domain. Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Binds to and translocates the guanine nucleotide exchange factors SOS (By similarity). Interacts with phosphorylated LAT2.
messages: Belongs to the GRB2/sem-5/DRK family.
messages: Cytoplasm
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9031:SLC25A6
gene id: 9031:SLC25A6
uniprot id: Q5ZLG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

9031:PRKCE
gene id: 9031:PRKCE
uniprot id: F1NG47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9031:SYF2
gene id: 9031:SYF2
uniprot id: F1P0B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

9031:MAP3K5
gene id: 9031:MAP3K5
uniprot id: A0A1D5PTJ8
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9031:TBC1D24
gene id: 9031:TBC1D24
uniprot id: A0A1D5P4W1
uniprot id: F1NEU9
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse
messages: Synapse

9031:MED28
gene id: 9031:MED28
uniprot id: A0A3Q2TXI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

9031:RPL15
gene id: 9031:RPL15
uniprot id: F1NQG5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9031:NME4
gene id: 9031:NME4
uniprot id: F1NG65
names: Similarity
messages: Belongs to the NDK family.

9031:ELOVL2
gene id: 9031:ELOVL2
uniprot id: E1BYE9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9031:CA15L
gene id: 9031:CA15L
uniprot id: F1NAI5
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9031:SMPDL3A
gene id: 9031:SMPDL3A
uniprot id: A0A3Q2TWN1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9031:CBLB
gene id: 9031:CBLB
uniprot id: F1NL77
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9031:CFTR
gene id: 9031:CFTR
uniprot id: A0A1D5PBN0
uniprot id: A0M8U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Recycling endosome membrane

9031:LETM1
gene id: 9031:LETM1
uniprot id: A0A1I7Q423
uniprot id: Q5ZK33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LETM1 family.
messages: Homohexamer.
messages: Membrane
messages: Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity).
messages: Mitochondrion inner membrane

9031:GNB1
gene id: 9031:GNB1
uniprot id: F1NLV4
uniprot id: Q5ZLB5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

9031:PKIG
gene id: 9031:PKIG
uniprot id: A0A1D5PU58
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9031:PTRF
gene id: 9031:PTRF
uniprot id: Q90885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9031:WNT4
gene id: 9031:WNT4
uniprot id: P49337
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Interacts with CPZ.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Predominantly expressed in the diencephalon neuromere D2.
messages: extracellular matrix

9031:OAT
gene id: 9031:OAT
uniprot id: Q5ZJ29
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9031:GTF2H2
gene id: 9031:GTF2H2
uniprot id: E1C9E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

9031:FAM192A
gene id: 9031:FAM192A
uniprot id: E1BUS4
names: Subcellular Location Annotation
messages: Nucleus

9031:GSTCD
gene id: 9031:GSTCD
uniprot id: F1NKT3
names: Similarity
messages: Belongs to the GSTCD family.

9031:CYP2J22
gene id: 9031:CYP2J22
uniprot id: A0A1L1RRG6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:ANKH
gene id: 9031:ANKH
uniprot id: Q5EEJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

9031:DPH5
gene id: 9031:DPH5
uniprot id: F1P418
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9031:TRAF5
gene id: 9031:TRAF5
uniprot id: Q805B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9031:RARS2
gene id: 9031:RARS2
uniprot id: E1C229
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9031:EIF4H
gene id: 9031:EIF4H
uniprot id: A0A1L1S0V6
uniprot id: F1NYA2
uniprot id: Q5ZMR0
names: Function
names: Subcellular Location Annotation
messages: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
messages: perinuclear region

9031:LHFPL5
gene id: 9031:LHFPL5
uniprot id: Q7ZZL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LHFP family.
messages: Cell membrane

9031:ILK
gene id: 9031:ILK
uniprot id: Q9DF58
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on serine residues.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cell membrane
messages: Interacts with PXN/PAXILLIN (via LD motif 4).
messages: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling.
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9031:OLFR6
gene id: 9031:OLFR6
uniprot id: P37072
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Odorant receptor.

9031:PRIM1
gene id: 9031:PRIM1
uniprot id: A0A1D5PGK7
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9031:RPS19BP1
gene id: 9031:RPS19BP1
uniprot id: Q5ZMG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: Direct regulator of SIRT1.
messages: nucleolus

9031:LOC421583
gene id: 9031:LOC421583
uniprot id: F1NVE0
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9031:HSPA4L
gene id: 9031:HSPA4L
uniprot id: Q5F3J8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9031:HOXD11
gene id: 9031:HOXD11
uniprot id: P24342
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Coordinately expressed in partially overlapping domains during wing development.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:ESYT2
gene id: 9031:ESYT2
uniprot id: A0A1D5P2W2
uniprot id: A0A3Q3AYW8
uniprot id: F1NW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:EAF1
gene id: 9031:EAF1
uniprot id: A0A1D5P3X7
names: Similarity
messages: Belongs to the EAF family.

9031:FMO3
gene id: 9031:FMO3
uniprot id: Q8QH01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:GPR183
gene id: 9031:GPR183
uniprot id: F1P0K6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:HS3ST1
gene id: 9031:HS3ST1
uniprot id: E1C4I5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:TAF8
gene id: 9031:TAF8
uniprot id: Q5ZMS1
uniprot id: R4GIW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF8 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs).
messages: Cytoplasm
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs). Mediates both basal and activator-dependent transcription.

9031:GDPD2
gene id: 9031:GDPD2
uniprot id: A0A1D5P5T7
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:VSX2
gene id: 9031:VSX2
uniprot id: Q9IAL1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex (PubMed:27477290). May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity).
messages: Belongs to the paired homeobox family.
messages: Expressed throughout the invaginating optic vesicles at stage 12, and uniformly throughout the neural retina from stage 14 to stage 18. Expressed in the spinal cord from stage 15 to stage 20.
messages: Nucleus
messages: Retina and spinal cord.

9031:LOC427025
gene id: 9031:LOC427025
uniprot id: A0A1D5PGU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

9031:NR4A3
gene id: 9031:NR4A3
uniprot id: E1BYS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:NDUFV3
gene id: 9031:NDUFV3
uniprot id: A0A1D5PFP1
uniprot id: D5M8S6
uniprot id: E1C699
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

9031:FN3K
gene id: 9031:FN3K
uniprot id: E1BRW8
names: Similarity
messages: Belongs to the fructosamine kinase family.

9031:MCEE
gene id: 9031:MCEE
uniprot id: E1BSK7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9031:ATIC
gene id: 9031:ATIC
uniprot id: P31335
uniprot id: Q5U784
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: AMP and XMP inhibit AICAR formyltransferase activity (By similarity). AICAR formyltransferase activity is competitively inhibited by 2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfo-phenyl)-1H-pyrazol-4-ylazo]-4-sulfo-benzoic acid (326203-A) (PubMed:15355974). FAICAR cyclization is competitively inhibited by 1,5-dihydroimidazo[4,5-c][1,2,6]thiadiazin-4(3H)-one-2,2-dioxide and the corresponding nucleoside and nucleoside monophosphate (PubMed:17324932).
messages: Belongs to the PurH family.
messages: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:12501179). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:12501179). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity).
messages: Homodimer (PubMed:11323713, PubMed:12501179). Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (By similarity).
messages: The IMP cyclohydrolase activity resides in the N-terminal region.
messages: The de novo purine synthesis pathway includes 10 sequential steps, beginning with phosphoribosyl pyrophosphate and ending with inositol monophosphate (IMP), the first purin compound of the pathway.

9031:IL6R
gene id: 9031:IL6R
uniprot id: Q5DWQ5
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

9031:STXBP3
gene id: 9031:STXBP3
uniprot id: A0A1D5NW10
uniprot id: A0A3Q3A3M8
uniprot id: E1BTS5
uniprot id: Q5ZIM9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9031:TAF3
gene id: 9031:TAF3
uniprot id: Q5F489
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF3 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts with TAF10 via the histone fold. Interacts with TAF13, TBP, SAP130 and GCN5L2. Interacts with TBPL2.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF3 forms the TFIID-A module together with TAF5 and TBP. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process.

9031:ALOX5AP
gene id: 9031:ALOX5AP
uniprot id: R4GHN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:BLOC1S1
gene id: 9031:BLOC1S1
uniprot id: A0A3Q3B116
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Mitochondrion intermembrane space

9031:HCCS
gene id: 9031:HCCS
uniprot id: F1NSX8
uniprot id: Q5F339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

9031:WASF3
gene id: 9031:WASF3
uniprot id: A0A3Q2UPF3
uniprot id: E1C2T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9031:LOC100859039
gene id: 9031:LOC100859039
uniprot id: A0A1D5P312
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:FAN1
gene id: 9031:FAN1
uniprot id: A0A3Q2UDF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

9031:NEK8
gene id: 9031:NEK8
uniprot id: A0A3Q2UF44
uniprot id: E1BRZ2
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9031:C26H6ORF125
gene id: 9031:C26H6ORF125
uniprot id: F1NC48
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9031:RGS8
gene id: 9031:RGS8
uniprot id: R4GJB7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: Perikaryon
messages: dendrite

9031:RIPK2
gene id: 9031:RIPK2
uniprot id: Q5ZJT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

9031:EGFLAM
gene id: 9031:EGFLAM
uniprot id: E1BQW4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:FAM20B
gene id: 9031:FAM20B
uniprot id: F1NZJ0
uniprot id: Q5ZI96
names: Similarity
messages: Belongs to the FAM20 family.

9031:ETFRF1
gene id: 9031:ETFRF1
uniprot id: E1BTS3
names: Similarity
messages: Belongs to the complex I LYR family.

9031:CSF3
gene id: 9031:CSF3
uniprot id: C0MN01
uniprot id: P13854
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage.
messages: Secreted

9031:CENPN
gene id: 9031:CENPN
uniprot id: Q1T765
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-N/CHL4 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere

9031:MPP5
gene id: 9031:MPP5
uniprot id: E1C3F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: tight junction

9031:ITGA3
gene id: 9031:ITGA3
uniprot id: Q98TT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9031:TFF3
gene id: 9031:TFF3
uniprot id: E1BZ37
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:HKDC1
gene id: 9031:HKDC1
uniprot id: E1BRU7
names: Similarity
messages: Belongs to the hexokinase family.

9031:CSGALNACT2
gene id: 9031:CSGALNACT2
uniprot id: E1C2T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9031:ITM2A
gene id: 9031:ITM2A
uniprot id: Q5F3H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9031:LAMB3
gene id: 9031:LAMB3
uniprot id: F1NLU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:LAMTOR5
gene id: 9031:LAMTOR5
uniprot id: F1NRX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

9031:ELOVL4
gene id: 9031:ELOVL4
uniprot id: E3VVZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9031:CACNG5
gene id: 9031:CACNG5
uniprot id: E1C4A6
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

9031:TMEM263
gene id: 9031:TMEM263
uniprot id: F1NZP4
uniprot id: Q5ZLA9
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Defect in TMEM263 may be a one of the causes of autosomal recessive dwarfism in Cornell K-strain white leghorns. A nonsense mutation truncates the protein and probably cause a dysfunctional protein. Autosomal dwarf chicken display small body stature by short shank length, with 30-40% reduced adult body weight despite normal hormonal concentration of GH and IGF1.
messages: May be involved in the growth pathway.
messages: Membrane

9031:C2H9ORF30
gene id: 9031:C2H9ORF30
uniprot id: E1BT69
names: Similarity
messages: Belongs to the MSANTD3 family.

9031:PRKD3
gene id: 9031:PRKD3
uniprot id: E1C6T4
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9031:MED18
gene id: 9031:MED18
uniprot id: R4GFA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:TNFAIP8L1
gene id: 9031:TNFAIP8L1
uniprot id: Q5ZJU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNFAIP8 family.
messages: Cytoplasm

9031:SPTSSA
gene id: 9031:SPTSSA
uniprot id: R4GJA8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:EGR1
gene id: 9031:EGR1
uniprot id: Q5ZLU9
uniprot id: Q8QG62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

9031:CMTM3
gene id: 9031:CMTM3
uniprot id: Q5ZI73
uniprot id: Q6L9F3
names: Subcellular Location Annotation
messages: Membrane

9031:WNT6
gene id: 9031:WNT6
uniprot id: Q3C2H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:EDIL3
gene id: 9031:EDIL3
uniprot id: A0A3Q3ADW5
uniprot id: F1NCN3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:NFE2L1
gene id: 9031:NFE2L1
uniprot id: Q5ZL67
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. CNC subfamily.
messages: CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses. Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response. Activates or represses expression of target genes, depending on the context (By similarity). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (By similarity).
messages: Cleaved at Leu-104 following retrotranslocation, releasing the protein from the endoplasmic reticulum membrane and forming the transcription factor NRF1 that translocates into the nucleus.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (By similarity).
messages: Interacts (via the bZIP domain) with small MAF protein (MAFF, MAFG or MAFK); required for binding to antioxidant response elements (AREs) on DNA.
messages: Nucleus
messages: The cholesterol recognition/amino acid consensus (CRAC) region directly binds cholesterol, as well as campesterol and 27-hydroxycholesterol. Has much lower affinity for epicholesterol.

9031:LOC101750836
gene id: 9031:LOC101750836
uniprot id: A0A1D5P2V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:CCDC126
gene id: 9031:CCDC126
uniprot id: E1BS45
names: Subcellular Location Annotation
messages: Secreted

9031:HAGH
gene id: 9031:HAGH
uniprot id: A0A3Q2U554
uniprot id: Q5ZI23
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.
messages: Produced by alternative initiation at Met-51 of isoform 1. Alternative initiation has been proven in human.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

9031:ARF5
gene id: 9031:ARF5
uniprot id: P49702
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9031:GABRB2
gene id: 9031:GABRB2
uniprot id: F6SVX7
uniprot id: Q90590
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:CNEP1R1
gene id: 9031:CNEP1R1
uniprot id: A0A1D5PB80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9031:TMEM68
gene id: 9031:TMEM68
uniprot id: Q5ZJD8
names: Subcellular Location Annotation
messages: Membrane

9031:AGTR1
gene id: 9031:AGTR1
uniprot id: P79785
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: C-terminal Ser or Thr residues may be phosphorylated.
messages: Cell membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

9031:NAA40
gene id: 9031:NAA40
uniprot id: A0A1D5P6G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

9031:ACVR2B
gene id: 9031:ACVR2B
uniprot id: Q90670
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: By activin.
messages: Expressed during the differentiation of neuroepithelium, of myotomes to muscle and of surface extoderm. Expressed in the dorsal root ganglia (DRG).
messages: Membrane
messages: Not expressed in hen anterior pituitary during the ovulatory cycle but expressed in the ovarian follicle.
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.

9031:CFC1
gene id: 9031:CFC1
uniprot id: Q9I8Q3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Cell membrane
messages: First detected in the early streak embryo, specifically in the epiblast layer. At the late streak stage, expression is condensed in the rostral half of the primitive streak. At HH stage 4 expression appeared for the first time in the mesendodermal layer of the presumptive prechordal plate rostrally and in the expanding mesoderm laterally. At HH stage 6, labeling in mesendodermal progenitors underlying the future forebrain level of the neuraxis reached its maximum, whereas mesoderm expression, which was restricted to the lateral plate, was accompanied by an underlying endodermal expression at the level of the heart-forming regions. Later gastrulation (HH stage 5-7) was marked by strong expression in the notochord, beneath the future floor plate of the neural tube. Expressed in Hensen node, within its mesenchymal core beneath the epiblast, and at a time when it is morphologically asymmetric.
messages: May play a role in mesoderm and/or neural patterning during gastrulation.
messages: Secreted

9031:GMDS
gene id: 9031:GMDS
uniprot id: A0A1D5PD70
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9031:SLC2A12
gene id: 9031:SLC2A12
uniprot id: F1P4J7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:IMPDH2
gene id: 9031:IMPDH2
uniprot id: Q5F4A4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9031:CDR2
gene id: 9031:CDR2
uniprot id: Q5ZJA3
names: Similarity
messages: Belongs to the CDR2 family.

9031:OTOP3
gene id: 9031:OTOP3
uniprot id: R4GK65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9031:APOOL
gene id: 9031:APOOL
uniprot id: Q5ZK55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Mitochondrion inner membrane

9031:C2orf49
gene id: 9031:C2orf49
uniprot id: Q5ZK74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9031:MRPL34
gene id: 9031:MRPL34
uniprot id: A0A1D5PAI1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

9031:APH1AL
gene id: 9031:APH1AL
uniprot id: E1C2N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

9031:VANGL1
gene id: 9031:VANGL1
uniprot id: E1C1K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9031:CSE1L
gene id: 9031:CSE1L
uniprot id: E1BV44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

9031:PARP14
gene id: 9031:PARP14
uniprot id: R4GFU1
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:AKAP9
gene id: 9031:AKAP9
uniprot id: A0A1D5PNE9
uniprot id: Q9W6V0
names: Subcellular Location Annotation
messages: centrosome

9031:LOC769121
gene id: 9031:LOC769121
uniprot id: A0A1D5NYV2
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:ITIH2
gene id: 9031:ITIH2
uniprot id: B3VE14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

9031:BLOC1S2
gene id: 9031:BLOC1S2
uniprot id: A0A1L1RL19
names: Similarity
messages: Belongs to the BLOC1S2 family.

9031:DNAJC27
gene id: 9031:DNAJC27
uniprot id: Q6IMM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: GTPase possibly involved in regulation of the MEK/ERK pathway.
messages: Nucleus

9031:LEF1
gene id: 9031:LEF1
uniprot id: A0A3Q3B1W2
uniprot id: O93345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9031:ENTPD6
gene id: 9031:ENTPD6
uniprot id: A0A1L1RPW8
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9031:CTDP1
gene id: 9031:CTDP1
uniprot id: A0A1D5PEM7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

9031:RAB11A
gene id: 9031:RAB11A
uniprot id: Q5ZJN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling (By similarity).
messages: phagosome

9031:HMGA2
gene id: 9031:HMGA2
uniprot id: O73816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9031:CDKN3
gene id: 9031:CDKN3
uniprot id: F1NIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family.
messages: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
messages: perinuclear region

9031:FUT9
gene id: 9031:FUT9
uniprot id: Q8UWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9031:TCF25
gene id: 9031:TCF25
uniprot id: E1C2G1
names: Similarity
messages: Belongs to the TCF25 family.

9031:ADMP
gene id: 9031:ADMP
uniprot id: Q9PVK1
names: Similarity
messages: Belongs to the TGF-beta family.

9031:STK38
gene id: 9031:STK38
uniprot id: E1C8Z7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:CAPN10
gene id: 9031:CAPN10
uniprot id: A0A1D5PVZ2
names: Similarity
messages: Belongs to the peptidase C2 family.

9031:UBE2G1
gene id: 9031:UBE2G1
uniprot id: Q5ZLH8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:KHDRBS2
gene id: 9031:KHDRBS2
uniprot id: E1BVW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDRBS family.
messages: Cytoplasm

9031:PRRX1
gene id: 9031:PRRX1
uniprot id: Q05437
uniprot id: Q8UVD3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At stage 10, expressed in the neural tube throughout the mesoderm. By early stage 13, expression becomes restricted to the lateral mesoderm in the trunk region and in the cranial region, to the dermomyotome, to the somatic mseoderm-derived pericardium and to a group of cells located ventral to the dermomyotome. Expression continues at high levels in the dermatome. In later stages, high expression found in the limb bud mesenchyme pharyngeal arches, the maxillary arches and the frontonasal mass and to a lesser extent, in the aorta, cardiac valve mesenchyme, the pericardial wall and the ventral foregut wall.
messages: Belongs to the paired homeobox family.
messages: Expressed predominantly in the mesodermal cells of the limb bud, visceral arches and craniofacial process, and at lower levels, in cranial mesenchyme, upper and lower eyelids, somites and cartilage of vertebra. Also found in the heart, especially the developing semilunar and atrioventricular valves and in the brain, in a distinct region of the ventral part of the hypothalamus as well as in a broader region of the telencephalon.
messages: Interacts with MAF and MAFB.
messages: May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face.
messages: Nucleus

9031:PARP11
gene id: 9031:PARP11
uniprot id: A0A1D5P5E7
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:ATG13
gene id: 9031:ATG13
uniprot id: A0A3Q2U2X5
uniprot id: A0A3Q3B1U1
uniprot id: E1BQS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9031:GK5
gene id: 9031:GK5
uniprot id: Q5ZMJ4
names: Similarity
messages: Belongs to the FGGY kinase family.

9031:OLFML3
gene id: 9031:OLFML3
uniprot id: Q25C36
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Expression first appears at Hensen's node and subsequently in the axial and paraxial mesoderm. When the neural tube closes, strong expression is transiently found in the roof plate region from the rostral midbrain to the hindbrain.
messages: Secreted
messages: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity).

9031:FAM96B
gene id: 9031:FAM96B
uniprot id: E1BWV0
names: Similarity
messages: Belongs to the MIP18 family.

9031:CENPL
gene id: 9031:CENPL
uniprot id: Q1T7C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-L/IML3 family.
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP.
messages: Nucleus
messages: centromere

9031:STAT5A
gene id: 9031:STAT5A
uniprot id: B9VVJ4
uniprot id: O93378
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9031:AIG1
gene id: 9031:AIG1
uniprot id: E1BS86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9031:H2AFY2
gene id: 9031:H2AFY2
uniprot id: E1BR08
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

9031:PAPSS1
gene id: 9031:PAPSS1
uniprot id: E1C8P2
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9031:GJB2
gene id: 9031:GJB2
uniprot id: E1C2J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:JMJD4
gene id: 9031:JMJD4
uniprot id: Q5ZHV5
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.
messages: Cytoplasm

9031:ZCCHC8
gene id: 9031:ZCCHC8
uniprot id: F1NEG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

9031:TMEM168
gene id: 9031:TMEM168
uniprot id: E1BXX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

9031:LMX1A
gene id: 9031:LMX1A
uniprot id: E1C2D6
names: Subcellular Location Annotation
messages: Nucleus

9031:FRK
gene id: 9031:FRK
uniprot id: E1C2F6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

9031:ATP10D
gene id: 9031:ATP10D
uniprot id: E1C8A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:MTFR1
gene id: 9031:MTFR1
uniprot id: Q9PTD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MTFR1 family.
messages: May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission.
messages: Mitochondrion
messages: Widely expressed in embryonic tissues with higher expression in cartilage and hypertrophic chondrocytes. Specifically expressed in hypertrophic chondrocytes (at protein level).

9031:HACD3
gene id: 9031:HACD3
uniprot id: Q5ZM57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1-signaling pathways leading to the modulation of gene expression.
messages: Endoplasmic reticulum membrane
messages: Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity.

9031:YRDC
gene id: 9031:YRDC
uniprot id: A0A3Q3A330
uniprot id: R4GGW9
names: Similarity
messages: Belongs to the SUA5 family.

9031:LOC107057554
gene id: 9031:LOC107057554
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:EXOC5
gene id: 9031:EXOC5
uniprot id: Q5F3N2
names: Function
names: Similarity
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9031:SET
gene id: 9031:SET
uniprot id: F2Z4L4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9031:RARB
gene id: 9031:RARB
uniprot id: P22448
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: By retinoic acid.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Heterodimer; with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.
messages: In the developing embryo, expressed in the limb bud mesenchyme, in cranofacial mesenchyme, and in hindbrain neuroectoderm. At stages 20, 24 and 28 of embryonic development, expressed ununiformly in facial primordia. Present in lateral nasal processes, at edges and corners of frontonasal mass and in the anterior part of the maxillary primordia. Expressed in mesenchyme at all stages of facial development. In the developing limb, isoform Beta-1 is expressed limb bud mesenchyme and ectoderm, then become restricted within perichondrial regions and loose connective tissue of the limb, while isoform Beta-2, expressed in subsets of similar tissues, in the proximal limb mesenchyme and in the initial mesenchymal condensate. later abundantly expressed in cells lateral to the digit cartilage.
messages: Nucleus
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for limb and craniofacial development.

9031:CYP27C1
gene id: 9031:CYP27C1
uniprot id: F1NZ08
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:SETD7
gene id: 9031:SETD7
uniprot id: F1P558
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

9031:DAD1
gene id: 9031:DAD1
uniprot id: A2NR64
uniprot id: O13113
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9031:SLC16A1
gene id: 9031:SLC16A1
uniprot id: Q5ZLZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

9031:GBP
gene id: 9031:GBP
uniprot id: Q90892
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9031:PRKCH
gene id: 9031:PRKCH
uniprot id: F1NJH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9031:NIPAL3
gene id: 9031:NIPAL3
uniprot id: E1BR96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9031:AFAP1
gene id: 9031:AFAP1
uniprot id: Q90738
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Functions as an adapter molecule that links other proteins to the actin cytoskeleton. May function in facilitating interactions between SRC and actin filaments. May modulate changes in actin filament integrity and induce lamellipodia formation. Can cross-link actin filaments into both network and bundle structures.
messages: Isoform 2 is specifically expressed in brain.
messages: Monomer and homomultimer. Interacts via its C-terminus with F-actin; probably involving AFAP1 multimers. Interacts with activated SRC SH3-SH2 domains. May interact with FYN SH3-SH2 domains. Interacts via its PH 1 domain with PRKCA, PRKCB, PRKCI.
messages: Phosphorylated on tyrosine residues by SRC.
messages: stress fiber

9031:SAMHD1
gene id: 9031:SAMHD1
uniprot id: Q5ZJL9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated and regulated via the combined actions of GTP and dNTPs (dATP, dGTP, dTTP and dCTP): Allosteric site 1 binds GTP, while allosteric site 2 binds dNTP. Allosteric activation promotes the formation of highly active homotetramers.
messages: Belongs to the SAMHD1 family.
messages: Binds 1 zinc ion per subunit.
messages: Chromosome
messages: Homodimer; in absence of GTP and dNTP. Homotetramer; in GTP- and dNTP-bound form (By similarity). Interacts with rbbp8/CtIP (By similarity).
messages: Nucleus
messages: Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication. Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation. Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity.

9031:VSNL1
gene id: 9031:VSNL1
uniprot id: P62764
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the recoverin family.
messages: Probably binds three calcium ions.
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.
messages: Widely expressed in the brain but not detectable in liver, heart or skeletal muscle.

9031:ATG9A
gene id: 9031:ATG9A
uniprot id: E1BVB2
uniprot id: Q3T8Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

9031:KCNH5
gene id: 9031:KCNH5
uniprot id: E1BXK7
names: Subcellular Location Annotation
messages: Membrane

9031:LPIN1
gene id: 9031:LPIN1
uniprot id: A0A3Q2TZZ2
names: Similarity
messages: Belongs to the lipin family.

9031:MCRIP1
gene id: 9031:MCRIP1
uniprot id: Q5ZIU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: May play a role in the regulation of the epithelial-mesenchymal transition.
messages: Nucleus
messages: Stress granule

9031:ADGRL3
gene id: 9031:ADGRL3
uniprot id: A0A1D5NUH8
uniprot id: A0A1D5P0T3
uniprot id: A0A1D5P667
uniprot id: A0A1D5P8C0
uniprot id: F1NWA7
names: Subcellular Location Annotation
messages: Membrane

9031:CRB2
gene id: 9031:CRB2
uniprot id: E1BYW1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TMEM123
gene id: 9031:TMEM123
uniprot id: Q5ZHZ6
uniprot id: Q5ZJI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9031:LAP3
gene id: 9031:LAP3
uniprot id: Q5ZJU9
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9031:KIF2C
gene id: 9031:KIF2C
uniprot id: A0A3Q2UJF4
uniprot id: F1NB03
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:CEP19
gene id: 9031:CEP19
uniprot id: F1P221
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

9031:NOP16
gene id: 9031:NOP16
uniprot id: E1C6R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9031:CLUL1
gene id: 9031:CLUL1
uniprot id: F1N8T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Secreted

9031:LOC414835
gene id: 9031:LOC414835
uniprot id: Q6W4W6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:METTL4
gene id: 9031:METTL4
uniprot id: A0A1D5PM33
names: Similarity
messages: Belongs to the MT-A70-like family.

9031:C1orf174
gene id: 9031:C1orf174
uniprot id: F1P3V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9031:LYPLA2
gene id: 9031:LYPLA2
uniprot id: E1BRI5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

9031:ATG4A
gene id: 9031:ATG4A
uniprot id: A0A1I7Q405
uniprot id: Q5ZIW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy.
messages: Cytoplasm
messages: The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins. Required for proteolytic activation and delipidation of ATG8 proteins.

9031:PDE11A
gene id: 9031:PDE11A
uniprot id: A0A1D5P7N2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:IL21
gene id: 9031:IL21
uniprot id: D3GGX2
uniprot id: Q58IU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9031:TGIF1
gene id: 9031:TGIF1
uniprot id: A0A1D5NW56
uniprot id: Q90655
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/TGIF homeobox family.
messages: Binds to the F' element of the APOVLDLII gene and represses its transcription.
messages: Nucleus

9031:MECOM
gene id: 9031:MECOM
uniprot id: A0A1D5P950
names: Subcellular Location Annotation
messages: Nucleus

9031:AMER1
gene id: 9031:AMER1
uniprot id: F1NGE5
names: Similarity
messages: Belongs to the Amer family.

9031:NT5C3A
gene id: 9031:NT5C3A
uniprot id: A0A1D5PVS5
uniprot id: Q5ZID6
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: By norepinephrine/NE and adenosine which are released by the embryo under hypoxic conditions. By stimulation of beta-adrenergic/adenosine receptors in definitive red blood cells (RBC).
messages: Cytoplasm
messages: Expressed at low levels until 13 dpc and the expression rises transiently between 13 dpc and 16 dpc.
messages: Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.

9031:WRNIP1
gene id: 9031:WRNIP1
uniprot id: F1P1N3
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

9031:CLCC1
gene id: 9031:CLCC1
uniprot id: F1P073
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

9031:PHC1
gene id: 9031:PHC1
uniprot id: Q5ZKD2
names: Subcellular Location Annotation
messages: Nucleus

9031:RHOT2
gene id: 9031:RHOT2
uniprot id: Q5ZM83
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.

9031:LOC771552
gene id: 9031:LOC771552
uniprot id: R4GGW5
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

9031:TXNL4B
gene id: 9031:TXNL4B
uniprot id: E1C0A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9031:RAPSN
gene id: 9031:RAPSN
uniprot id: O42393
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.
messages: Belongs to the RAPsyn family.
messages: Cell membrane
messages: Expressed in muscle fibers and in neurons.
messages: Postsynaptic cell membrane
messages: Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity).
messages: cytoskeleton

9031:C2H5ORF22
gene id: 9031:C2H5ORF22
uniprot id: E1C2V6
names: Similarity
messages: Belongs to the UPF0489 family.

9031:ANOS1
gene id: 9031:ANOS1
uniprot id: P33005
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell surface
messages: Mainly expressed in neurons of the central nervous system during the second half of embryonic life. Expressed in mitral neurons of the olfactory bulbs, striatal neurons, Purkinje cells of the cerebellum, retinal neurons and neurons of the brainstem and spinal cord.
messages: May be an adhesion-like molecule with anti-protease activity.

9031:USP15
gene id: 9031:USP15
uniprot id: A0A1D5P1U9
uniprot id: A0A1D5P9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus

9031:LEPROT
gene id: 9031:LEPROT
uniprot id: Q5ZJD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Involved in protein trafficking. May be involved in the down-regulation of membrane protein levels (By similarity).

9031:CABIN1
gene id: 9031:CABIN1
uniprot id: A0A1D5PK58
uniprot id: E1BUF4
names: Subcellular Location Annotation
messages: Nucleus

9031:PUS1
gene id: 9031:PUS1
uniprot id: F1NZ90
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9031:CALR3
gene id: 9031:CALR3
uniprot id: F1P2G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9031:RPSAP58
gene id: 9031:RPSAP58
uniprot id: P50890
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

9031:MMP10
gene id: 9031:MMP10
uniprot id: E1C9E0
names: Similarity
messages: Belongs to the peptidase M10A family.

9031:ARPC4
gene id: 9031:ARPC4
uniprot id: F1P010
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

9031:CCNH
gene id: 9031:CCNH
uniprot id: A0A1L1RPK0
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

9031:HCN2
gene id: 9031:HCN2
uniprot id: F1NLU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9031:KCNF1
gene id: 9031:KCNF1
uniprot id: F1NK95
names: Subcellular Location Annotation
messages: Membrane

9031:RTRAF
gene id: 9031:RTRAF
uniprot id: Q90706
names: Similarity
messages: Belongs to the RTRAF family.

9031:TLE4
gene id: 9031:TLE4
uniprot id: Q8JIM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9031:ZP3
gene id: 9031:ZP3
uniprot id: P79762
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, which mediates species-specific sperm binding. Directly binds to sperm. Important for egg fertilization.
messages: Detected in the ovarian perivitteline layer. Detected in granulosa cells in ovarian follicle (at protein level). Detected in granulosa cells in ovarian follicle.
messages: Homodimer. Forms higher oligomers, once its C-terminus has been proteolytically removed. Forms heterooligomers with other zona pellucida glycoproteins (By similarity).
messages: N-glycosylated.
messages: O-glycosylated. O-glycosylation at Thr-168 is important for efficient interaction with the sperm head.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: extracellular matrix

9031:BSG
gene id: 9031:BSG
uniprot id: P17790
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Brain endothelial cells, kidney epithelial cells and erythroblasts (at protein level).
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).
messages: Interacts with NXNL1, SLC2A1 and SLC16A1.
messages: N-glycosylated.
messages: Photoreceptor inner segment
messages: Retinal cone photoreceptors (at protein level).
messages: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (By similarity). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity).
messages: photoreceptor outer segment

9031:PCDHA6
gene id: 9031:PCDHA6
uniprot id: Q6R0I5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:UBE2E3
gene id: 9031:UBE2E3
uniprot id: A0A3Q2UHE7
uniprot id: E1BQY2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:CLASP1
gene id: 9031:CLASP1
uniprot id: E1BVC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: centrosome
messages: kinetochore
messages: trans-Golgi network

9031:HK1
gene id: 9031:HK1
uniprot id: Q8AYP8
names: Similarity
messages: Belongs to the hexokinase family.

9031:NAMPTP1
gene id: 9031:NAMPTP1
uniprot id: Q58I02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9031:SLC52A3
gene id: 9031:SLC52A3
uniprot id: H9KZD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9031:STAMBPL1
gene id: 9031:STAMBPL1
uniprot id: E1BUJ2
names: Similarity
messages: Belongs to the peptidase M67C family.

9031:MTHFD1
gene id: 9031:MTHFD1
uniprot id: F1NMC3
uniprot id: Q5ZI76
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9031:RALGPS2
gene id: 9031:RALGPS2
uniprot id: Q5ZJK0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor. May be involved in cytoskeletal organization.
messages: The PH domain mediates binding to membranes.

9031:SLC29A4
gene id: 9031:SLC29A4
uniprot id: F1NNK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9031:PDK3
gene id: 9031:PDK3
uniprot id: Q5ZLT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9031:KPNA3
gene id: 9031:KPNA3
uniprot id: C6KIB2
uniprot id: F1NV68
names: Similarity
messages: Belongs to the importin alpha family.

9031:RPAP3
gene id: 9031:RPAP3
uniprot id: Q5ZKQ3
names: Function
names: Similarity
messages: Belongs to the RPAP3 family.
messages: May for an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein.

9031:PIK3CG
gene id: 9031:PIK3CG
uniprot id: E1C093
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:CYP21A1
gene id: 9031:CYP21A1
uniprot id: A5HUM5
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:YWHAE
gene id: 9031:YWHAE
uniprot id: Q5ZMT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.
messages: Nucleus

9031:SPDL1
gene id: 9031:SPDL1
uniprot id: E1BW90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spindly family.
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.
messages: kinetochore

9031:MARCKS
gene id: 9031:MARCKS
uniprot id: A0A1D5PDE6
uniprot id: P16527
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MARCKS family.
messages: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
messages: Membrane
messages: cytoskeleton

9031:SVOP
gene id: 9031:SVOP
uniprot id: A0A1D5NXA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

9031:LRP12
gene id: 9031:LRP12
uniprot id: A0A1D5PL81
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ARAP3
gene id: 9031:ARAP3
uniprot id: A0A1D5PEH9
uniprot id: E1C2Q5
names: Subcellular Location Annotation
messages: Cytoplasm

9031:MEP1A
gene id: 9031:MEP1A
uniprot id: A0A1D5P6N4
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:AVPR1B
gene id: 9031:AVPR1B
uniprot id: Q90YN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

9031:CD109
gene id: 9031:CD109
uniprot id: F1NX21
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

9031:NPLOC4
gene id: 9031:NPLOC4
uniprot id: A0A1L1RME9
names: Similarity
messages: Belongs to the NPL4 family.

9031:ORMDL2
gene id: 9031:ORMDL2
uniprot id: Q5ZIU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Negative regulator of sphingolipid synthesis.

9031:MAT2B
gene id: 9031:MAT2B
uniprot id: E1BTX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

9031:NSG1
gene id: 9031:NSG1
uniprot id: Q8QFP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSG family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi stack membrane
messages: Late endosome membrane
messages: Lysosome lumen
messages: Membrane
messages: Plays a role in the recycling mechanism in neurons of multiple receptors and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway.
messages: Recycling endosome membrane
messages: dendrite
messages: multivesicular body membrane
messages: trans-Golgi network membrane

9031:LOC419888
gene id: 9031:LOC419888
uniprot id: F1NXG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9031:ADAMTS1
gene id: 9031:ADAMTS1
uniprot id: A0A1D5NX16
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:KIF4B
gene id: 9031:KIF4B
uniprot id: Q90640
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily.
messages: Binds 1 [4Fe-4S] cluster (By similarity). In the presence of oxygen, the [4Fe-4S] cluster may be converted to [2Fe-2S] (By similarity).
messages: Chromosome
messages: Expressed in proliferating cells; neuroepithelium of embryos.
messages: Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Required for mitotic chromosomal positioning and bipolar spindle stabilization.
messages: Nucleus
messages: cytoskeleton

9031:PCBD1
gene id: 9031:PCBD1
uniprot id: O73930
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
messages: Cytoplasm
messages: Homotetramer and homodimer.
messages: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity). Also acts as a coactivator for HNF1B-dependent transcription (By similarity).
messages: Nucleus
messages: The major tissues expressing cDcoH are hypothalamus, kidney and liver.

9031:RPS6KA1
gene id: 9031:RPS6KA1
uniprot id: A0A3Q2U5L9
uniprot id: A0A3Q3ADZ8
uniprot id: A0A3Q3AVG7
uniprot id: P18652
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Activated by multiple phosphorylations on threonine and serine residues.
messages: Autophosphorylated on Ser-398, as part of the activation process.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription.
messages: Small and large intestine, spleen, stomach, and bursa, and to a lesser extent lung and kidney.

9031:SSTR2
gene id: 9031:SSTR2
uniprot id: Q58G84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

9031:SNX9
gene id: 9031:SNX9
uniprot id: E1BTY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9031:NTRK3
gene id: 9031:NTRK3
uniprot id: Q91044
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Interacts with PTPRS (PubMed:17967490, PubMed:25385546).
messages: Expression occurs in the 2 dpc embryo with increasing levels later in development. In the 9 dpc embryo highest levels are found in brain and spinal cord with intermediate levels in eye, heart, gut and muscle. Low levels are found in kidney, liver, skin and yolk sac.
messages: Ligand-mediated auto-phosphorylation.
messages: Membrane
messages: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity). The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells (PubMed:8060621).
messages: The kinase domain is of 19 aa instead of 39aa in the isoform alpha-KD due to a frameshift.

9031:CEP55
gene id: 9031:CEP55
uniprot id: E1C2P7
names: Subcellular Location Annotation
messages: Cytoplasm

9031:MIS12
gene id: 9031:MIS12
uniprot id: Q1T769
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
messages: kinetochore

9031:HSD17B11
gene id: 9031:HSD17B11
uniprot id: F1NPQ5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:TEAD4
gene id: 9031:TEAD4
uniprot id: P48984
names: Caution
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Enriched in cardiac and skeletal muscle.
messages: Isoform B has probably a transactivation capacity that is lacking in the other isoforms. Isoform D may be defective in DNA binding.
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differentially activate transcription.
messages: Was originally called TEF-1, but is the ortholog of mammalian TEF-3.

9031:AVPR1A
gene id: 9031:AVPR1A
uniprot id: A8CWP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

9031:GSK3A
gene id: 9031:GSK3A
uniprot id: A0A3Q2TVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

9031:PRPF19
gene id: 9031:PRPF19
uniprot id: Q5ZMA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Cytoplasm
messages: Homotetramer. Component of activated, catalytic and post-catalytic spliceosomes. Component of the NTC complex (or PRP19-associated complex) which is associated with the spliceosome. Interacts with KHDC4 (By similarity).
messages: Lipid droplet
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity.
messages: nucleoplasm
messages: spindle

9031:ACY1
gene id: 9031:ACY1
uniprot id: A0A1D5PAU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

9031:NOP14
gene id: 9031:NOP14
uniprot id: E1C936
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

9031:BRF2
gene id: 9031:BRF2
uniprot id: E1C4I7
names: Similarity
messages: Belongs to the TFIIB family.

9031:SKA2P1
gene id: 9031:SKA2P1
uniprot id: E1BWA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

9031:SOX2
gene id: 9031:SOX2
uniprot id: A0A1D5NY63
uniprot id: P48430
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expression is maximal at stages 24-31, then begins to decline. Expression is low by stage 37 and is absent by stage 39. Does not appear to be expressed in adults.
messages: First expressed in the embryonic neural plate shortly before closure and expression continues in the neural tube. From stage 16 onwards, expressed throughout the CNS including the brain, with expression predominant in the undifferentiated cells of the neural epithelium. Also expressed at a low level in the retina and the gut epithelium. Highly expressed in the lens placode at stage 13 and in the lens at stage 17.
messages: It is uncertain whether Met-1 or Met-4 is the initiator.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activator (PubMed:7628452). Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3' (PubMed:7628452). In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens (PubMed:7628452). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (PubMed:14517545). May function as a switch in neuronal development (PubMed:7748786).

9031:C16orf72
gene id: 9031:C16orf72
uniprot id: E1BV25
names: Similarity
messages: Belongs to the TAPR1 family.

9031:CLTC
gene id: 9031:CLTC
uniprot id: F1NW23
uniprot id: Q8UUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9031:PFKM
gene id: 9031:PFKM
uniprot id: Q90YA3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ADORA2A
gene id: 9031:ADORA2A
uniprot id: E1BXP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9031:LAMA4
gene id: 9031:LAMA4
uniprot id: F1NSZ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CLIP1
gene id: 9031:CLIP1
uniprot id: O42184
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin.
messages: cytoskeleton
messages: ruffle

9031:CYP19A1
gene id: 9031:CYP19A1
uniprot id: F1NRL7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:NEIL3
gene id: 9031:NEIL3
uniprot id: E1C286
names: Similarity
messages: Belongs to the FPG family.

9031:PLOD1
gene id: 9031:PLOD1
uniprot id: P24802
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
messages: Homodimer.
messages: Rough endoplasmic reticulum membrane

9031:NUDT16L1
gene id: 9031:NUDT16L1
uniprot id: Q9IAY5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although strongly related to the nudix NUDT16 protein, lacks the Nudix box and is therefore not related to the rest of the family. Lacks a number of residues which are necessary for hydrolase activity and does not play a role in U8 snoRNA decapping activity.
messages: Belongs to the Nudix hydrolase family. TIRR subfamily.
messages: Cell membrane
messages: Interacts (via the cytoplasmic part) with syndecan-4 (SDC4), but not with other syndecan proteins (PubMed:10633082).
messages: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin.
messages: Myristoylated in vitro; additional evidence is however required to confirm myristoylation in vivo.
messages: Nucleus
messages: Ubiquitously expressed. Expressed in embryonic brain, eyes, gizzard, heart, intestine, kidney, liver, tibia and skin.
messages: cytoskeleton
messages: focal adhesion

9031:PUM1
gene id: 9031:PUM1
uniprot id: Q2VB19
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Detected in embryonic male and female gonads, heart, liver and muscle. Detected in adult brain, testis, ovary, heart, lung, spleen, kidney and muscle.
messages: P-body
messages: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs.
messages: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. RNA-binding occurs on the concave side of the surface. PUM1 is composed of 8 pumilio repeats of 36 residues; each repeat binds a single nucleotide in its RNA target. Residues at positions 12 and 16 of the pumilio repeat bind each RNA base via hydrogen bonding or van der Waals contacts with the Watson-Crick edge, while the amino acid at position 13 makes a stacking interaction. The recognition of RNA by pumilio repeats is base specific: cysteine and glutamine at position 12 and 16, respectively, bind adenine; asparagine and glutamine bind uracil; and serine and glutamate bind guanine.

9031:SEC63
gene id: 9031:SEC63
uniprot id: E1C0C3
names: Subcellular Location Annotation
messages: Membrane

9031:EDN2
gene id: 9031:EDN2
uniprot id: E1C482
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9031:RASGRP3
gene id: 9031:RASGRP3
uniprot id: Q5ZID9
names: Similarity
messages: Belongs to the RASGRP family.

9031:BCCIP
gene id: 9031:BCCIP
uniprot id: E1BUA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: spindle pole

9031:TMEM8C
gene id: 9031:TMEM8C
uniprot id: A0A0D5WB77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

9031:B3GNT7
gene id: 9031:B3GNT7
uniprot id: F1NU54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:IGHMBP2
gene id: 9031:IGHMBP2
uniprot id: E1BY42
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

9031:SYNJ2BP
gene id: 9031:SYNJ2BP
uniprot id: F1P042
names: Similarity
messages: Belongs to the DeSI family.

9031:CCR8
gene id: 9031:CCR8
uniprot id: A0A1D5P622
uniprot id: Q5ZI02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9031:CENPO
gene id: 9031:CENPO
uniprot id: Q1T7B8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-O/MCM21 family.
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). Involved in kinetochore assembly and required for recovery from spindle damage.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP. Component of a discrete complex composed of at least CENPO, CENPP, CENPQ, CENPR and CENPU.
messages: Increases time to progress through G2/M phase.
messages: Nucleus
messages: centromere

9031:SMAD1
gene id: 9031:SMAD1
uniprot id: Q56IA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:UBE2G2
gene id: 9031:UBE2G2
uniprot id: E1C9E7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:KCNK4
gene id: 9031:KCNK4
uniprot id: F7AVB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9031:BRPF3
gene id: 9031:BRPF3
uniprot id: A0A3Q2U1W3
names: Subcellular Location Annotation
messages: Nucleus

9031:IL17REL
gene id: 9031:IL17REL
uniprot id: E1BQL9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:RPS14
gene id: 9031:RPS14
uniprot id: Q5ZHW8
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9031:TM7SF3
gene id: 9031:TM7SF3
uniprot id: A0A1D5PTV5
names: Subcellular Location Annotation
messages: Membrane

9031:TIE1
gene id: 9031:TIE1
uniprot id: F1NGV4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:GMPPB
gene id: 9031:GMPPB
uniprot id: F1P574
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9031:CAMK2B
gene id: 9031:CAMK2B
uniprot id: O93560
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9031:GLYCTK
gene id: 9031:GLYCTK
uniprot id: A0A3Q2U5V7
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9031:MOCOS
gene id: 9031:MOCOS
uniprot id: F1NQ69
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

9031:RNASE6
gene id: 9031:RNASE6
uniprot id: P27043
uniprot id: Q27J91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pancreatic ribonuclease family.
messages: Homodimer. Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur (By similarity).
messages: Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
messages: Secreted
messages: nucleolus
messages: secretory vesicle lumen

9031:FAM234A
gene id: 9031:FAM234A
uniprot id: A0A1D5P6S9
names: Similarity
messages: Belongs to the FAM234 family.

9031:DCAF12L2
gene id: 9031:DCAF12L2
uniprot id: Q5F3R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DCAF12 family.
messages: Component of the DCX(DCAF12) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF12 and RBX1.
messages: Cytoplasm
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, leading to their ubiquitination and degradation.
messages: centrosome

9031:IGF2
gene id: 9031:IGF2
uniprot id: P33717
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.

9031:HS2ST1
gene id: 9031:HS2ST1
uniprot id: Q76KB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sulfotransferase 3 family.
messages: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes.
messages: Expressed in heart, limb, head and trunk. At stages 20 and 24, it is expressed in the most regions of the first and second pharyngeal arche. In both wing and leg buds, it is detected at the overlying ectoderm and mesenchyme throughout stages 21, 23 and 24.
messages: Golgi apparatus membrane
messages: Homotrimer.

9031:NDFIP2
gene id: 9031:NDFIP2
uniprot id: Q5F3V5
names: Subcellular Location Annotation
messages: Membrane

9031:ITPA
gene id: 9031:ITPA
uniprot id: F1NLH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

9031:SOX4
gene id: 9031:SOX4
uniprot id: Q5J7B6
names: Subcellular Location Annotation
messages: Nucleus

9031:LOC428144
gene id: 9031:LOC428144
uniprot id: A0A4P9IVJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9031:SLC6A12
gene id: 9031:SLC6A12
uniprot id: E1BQT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:RRAGA
gene id: 9031:RRAGA
uniprot id: A0A1D5PFS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9031:BUD13
gene id: 9031:BUD13
uniprot id: A0A3Q2U6I1
uniprot id: Q5ZIJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC26 family.
messages: Involved in pre-mRNA splicing as component of the activated spliceosome.
messages: Nucleus
messages: Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed of at least 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA.

9031:CDV3
gene id: 9031:CDV3
uniprot id: Q5ZLH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDV3 family.
messages: Cytoplasm

9031:FAM45A
gene id: 9031:FAM45A
uniprot id: A0A1L1RYH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

9031:SLC35A1
gene id: 9031:SLC35A1
uniprot id: A0A1D5PV25
uniprot id: Q8AW01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

9031:KIF23
gene id: 9031:KIF23
uniprot id: A0A1D5PDE8
uniprot id: Q5ZI55
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:RARRES2
gene id: 9031:RARRES2
uniprot id: A0A0K0PUH6
names: Subcellular Location Annotation
messages: Secreted

9031:GALR1
gene id: 9031:GALR1
uniprot id: B2ZE94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:TK1
gene id: 9031:TK1
uniprot id: P04047
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration.
messages: Cytoplasm
messages: Homotetramer. Tetramerization from dimerization is induced by ATP and increases catalytic efficiency due to a high affinity for thymidine. Tetramerization is inhibited by phosphorylation at Ser-13. Interacts (via the KEN box) with FZR1.
messages: KEN box sequence located in the C-terminal region is required for its mitotic degradation by the APC/C-FZR1 ubiquitin ligase and interaction capability with FZR1.
messages: Phosphorylated on Ser-13 in mitosis. Phosphorylation of Ser-13 by CDK1 during mitosis reduces homotetramerization and catalytic efficiency when DNA replication is complete and intracellular TK1 is still present at a high level.
messages: Polyubiquitinated. Postmitosis, ubiquitination leads to proteasomal degradation. The KEN box sequence located at the C-terminal region targets for degradation by the anaphase promoting complex (APC/C) activated and rate-limited by FZR1.
messages: Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

9031:UXS1
gene id: 9031:UXS1
uniprot id: E1BV28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

9031:PABIR2
gene id: 9031:PABIR2
uniprot id: E1C1H5
names: Similarity
messages: Belongs to the FAM122 family.

9031:UFL1
gene id: 9031:UFL1
uniprot id: F1NCY5
names: Similarity
messages: Belongs to the UFL1 family.

9031:RPL4
gene id: 9031:RPL4
uniprot id: Q5ZII1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

9031:MRPL43
gene id: 9031:MRPL43
uniprot id: Q5ZHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9031:CYP1A1
gene id: 9031:CYP1A1
uniprot id: P79760
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:CTU2
gene id: 9031:CTU2
uniprot id: A0A3Q2U523
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

9031:PKIB
gene id: 9031:PKIB
uniprot id: R4GIA8
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9031:TCF15
gene id: 9031:TCF15
uniprot id: P79782
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes.
messages: First detected in a subpopulation of cells lateral to the primitive streak corresponding with the area of prospective segmental plate mesoderm and somites (PubMed:9187085, PubMed:9281340). Later in development, it is expressed throughout the segmental plate and newly formed somites and is restricted to the paraxial mesoderm (PubMed:9187085, PubMed:9281340). After somite formation, its expression decline in the lateral region of the somite (PubMed:9187085, PubMed:9281340). Later it is expressed at highest levels at the cranial and caudal edges of the more mature somites (PubMed:9187085, PubMed:9281340). As the dermomyotome and sclerotome formed, expression disappeared from the ventral regions of the somite, but persisted in the dermomyotome (PubMed:9187085, PubMed:9281340). When the dermomyotome developed further into the dermatome and myotome, expression is detected in both compartments, although more prominently in the dermatome (PubMed:9187085, PubMed:9281340). Expression was also detected in migrating precursors of tongue muscle and in the limb buds (PubMed:9187085, PubMed:9281340).
messages: Heterodimer; efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus
messages: Surface ectoderm and neural tube are the sources of inductive signals required for gene expression and for somite formation.

9031:PSMD1
gene id: 9031:PSMD1
uniprot id: A0A1D5PI39
uniprot id: Q5F418
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD1. Interacts with ADRM1.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9031:LIFR
gene id: 9031:LIFR
uniprot id: Q8QFQ7
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9031:GJA1
gene id: 9031:GJA1
uniprot id: P14154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: In all tissues, but mostly in lens.
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles.
messages: gap junction

9031:RCL1
gene id: 9031:RCL1
uniprot id: E1C1K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

9031:DEFB4A
gene id: 9031:DEFB4A
uniprot id: P46158
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Detected in the theca layer of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages. In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens.
messages: Expressed in circulating heterophil granulocytes and bone marrow (at protein level). Strong expression in the bone marrow, lung and testis. Moderate expression in the bursa and intestine. Low expression in the cloaca, gall bladder, brain, pancreas, trachea, air sacs and spleen. Expressed in the vagina, ovarian stroma and the theca layer of the ovarian follicle, but not in the granulosa layer of the ovarian follicle.
messages: Not induced in the ovarian follicle by intravenous injection of LPS. Expression in cultured vaginal cells is increased by LPS and S.enteritidis.
messages: Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans.
messages: Secreted

9031:ATP6V1C1
gene id: 9031:ATP6V1C1
uniprot id: A0A1D5PA09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9031:SLC9A3R2
gene id: 9031:SLC9A3R2
uniprot id: F1NQR2
names: Function
names: Subcellular Location Annotation
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

9031:JAK3
gene id: 9031:JAK3
uniprot id: O42291
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system

9031:ARHGDIB
gene id: 9031:ARHGDIB
uniprot id: F1NLT8
names: Similarity
messages: Belongs to the Rho GDI family.

9031:DNAL4
gene id: 9031:DNAL4
uniprot id: Q5ZHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9031:SPPL3
gene id: 9031:SPPL3
uniprot id: E1C173
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9031:WDR82
gene id: 9031:WDR82
uniprot id: Q5ZMV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SWD2 family.
messages: Chromosome
messages: Component of the SET1 complex.
messages: Nucleus
messages: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

9031:NCF2
gene id: 9031:NCF2
uniprot id: F1NIH3
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

9031:EDEM2
gene id: 9031:EDEM2
uniprot id: A0A1D5PFY5
uniprot id: A0A1D5PW95
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9031:LOC101747844
gene id: 9031:LOC101747844
uniprot id: F1NY83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:METRNL
gene id: 9031:METRNL
uniprot id: R4GHN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the meteorin family.
messages: Secreted

9031:MTIF3
gene id: 9031:MTIF3
uniprot id: A0A3Q2UJN4
uniprot id: F1P2M3
names: Similarity
messages: Belongs to the IF-3 family.

9031:STOML1
gene id: 9031:STOML1
uniprot id: F1NSB5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9031:EXOC3L4
gene id: 9031:EXOC3L4
uniprot id: F1P1M3
names: Similarity
messages: Belongs to the SEC6 family.

9031:RPS27
gene id: 9031:RPS27
uniprot id: A0A1D5NZ06
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9031:SLCO1C1
gene id: 9031:SLCO1C1
uniprot id: Q2PGG8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:NDUFB8
gene id: 9031:NDUFB8
uniprot id: Q5ZJW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:GOLGA5
gene id: 9031:GOLGA5
uniprot id: E1C947
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

9031:FAM32A
gene id: 9031:FAM32A
uniprot id: A0A1D5PDZ1
names: Similarity
messages: Belongs to the FAM32 family.

9031:MSGN1
gene id: 9031:MSGN1
uniprot id: Q9DEQ9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in the presomitic mesoderm preceding the formation of somites. At stage 4 expressed in and around the primitive streak. During subsequent development, expression domain persists, and gradually retracts in parallel to the retracting Hensen's node towards the caudal end. Expression begins to accumulate in gastrulating mesoderm and is later restricted to paraxial mesoderm, prior to the onset of somite formation. No expression is seen within somites, nor in the tailbud mesoderm.
messages: Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).
messages: Nucleus

9031:GCHFR
gene id: 9031:GCHFR
uniprot id: A0A1D5PZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

9031:LZTFL1
gene id: 9031:LZTFL1
uniprot id: A0A3Q3B012
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9031:SEPTIN7
gene id: 9031:SEPTIN7
uniprot id: Q5F3T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium axoneme
messages: kinetochore
messages: spindle

9031:NATD1
gene id: 9031:NATD1
uniprot id: Q5ZJI6
names: Similarity
messages: Belongs to the NATD1 family.

9031:RNF182
gene id: 9031:RNF182
uniprot id: E1BZ35
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

9031:LOC768958
gene id: 9031:LOC768958
uniprot id: A0A3Q2UAM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:NUP93
gene id: 9031:NUP93
uniprot id: A0A1D5PFL9
uniprot id: Q5F386
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9031:VAMP7
gene id: 9031:VAMP7
uniprot id: Q5ZL74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity).
messages: Late endosome membrane
messages: Lysosome membrane
messages: phagosome membrane
messages: secretory vesicle membrane
messages: synaptosome
messages: trans-Golgi network membrane

9031:CHIA
gene id: 9031:CHIA
uniprot id: Q8AV87
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

9031:TUBB6
gene id: 9031:TUBB6
uniprot id: P09653
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9031:SIAH3
gene id: 9031:SIAH3
uniprot id: R4GKE1
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9031:GDI1
gene id: 9031:GDI1
uniprot id: O93382
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9031:TMLHE
gene id: 9031:TMLHE
uniprot id: Q5F4B3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gamma-BBH/TMLD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
messages: Homodimer.
messages: Mitochondrion matrix

9031:ETFDH
gene id: 9031:ETFDH
uniprot id: Q5F3D8
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9031:METTL9
gene id: 9031:METTL9
uniprot id: Q5ZMH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the METTL9 family.
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (By similarity). Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid); 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (By similarity).

9031:AGL
gene id: 9031:AGL
uniprot id: A0A1D5PF87
uniprot id: F1NX83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

9031:SHTN1
gene id: 9031:SHTN1
uniprot id: A0A3Q3AY90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9031:DPYD
gene id: 9031:DPYD
uniprot id: A0A3Q2TU25
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

9031:PCDHGA2
gene id: 9031:PCDHGA2
uniprot id: Q6EI13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:FAM151B
gene id: 9031:FAM151B
uniprot id: F1ND62
names: Similarity
messages: Belongs to the FAM151 family.

9031:ERLIN2
gene id: 9031:ERLIN2
uniprot id: F1NBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Membrane

9031:CLTCL1
gene id: 9031:CLTCL1
uniprot id: A0A1D5P650
uniprot id: A0A1D5PAU8
uniprot id: A0A1D5PDC1
uniprot id: A0A1D5PW75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

9031:GNA11
gene id: 9031:GNA11
uniprot id: Q71RI7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9031:SHROOM4
gene id: 9031:SHROOM4
uniprot id: A0A1D5P268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9031:SLC9A9
gene id: 9031:SLC9A9
uniprot id: Q5F3I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

9031:EIF2D
gene id: 9031:EIF2D
uniprot id: F1NDA1
names: Similarity
messages: Belongs to the eIF2D family.

9031:ELOVL6
gene id: 9031:ELOVL6
uniprot id: E3VVZ9
uniprot id: Q5ZJR8
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The reaction is stimulated by the presence of HSD17B12, the enzyme catalyzing the second step of the elongation cycle.

9031:GRPEL1
gene id: 9031:GRPEL1
uniprot id: Q5ZHV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9031:GUCA1B
gene id: 9031:GUCA1B
uniprot id: P79881
names: Function
names: Miscellaneous
names: Subunit
names: Tissue Specificity
messages: Binds three calcium ions.
messages: Retina and pineal gland.
messages: Stimulates synthesis of cGMP in photoreceptors. Thought to mediate Ca(2+)-sensitive regulation of retinal guanylyl cyclase (GC), a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).
messages: Undergoes dimerization at low calcium ions concentration, while the presence of calcium ions inhibits its dimerization. Dimerization correlates with its ability to activate GC.

9031:LOC420160
gene id: 9031:LOC420160
uniprot id: A0A1D5NWI4
uniprot id: A0A1D5PFI5
uniprot id: F1NZ37
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:GVINP1
gene id: 9031:GVINP1
uniprot id: F1NHR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9031:SENP6
gene id: 9031:SENP6
uniprot id: A0A1D5NZR4
names: Similarity
messages: Belongs to the peptidase C48 family.

9031:CXCL13L3
gene id: 9031:CXCL13L3
uniprot id: G4U4M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9031:ASPA
gene id: 9031:ASPA
uniprot id: E1BVP5
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.

9031:PELI2
gene id: 9031:PELI2
uniprot id: F1NF65
names: Similarity
messages: Belongs to the pellino family.

9031:TNFAIP1
gene id: 9031:TNFAIP1
uniprot id: Q5F3E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BACURD family.
messages: Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1.
messages: Cytoplasm
messages: Endosome
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

9031:ALDH3A2
gene id: 9031:ALDH3A2
uniprot id: Q5ZLE2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9031:EXOSC9
gene id: 9031:EXOSC9
uniprot id: Q6B7Z6
names: Subcellular Location Annotation
messages: Cytoplasm

9031:SPTSSBL
gene id: 9031:SPTSSBL
uniprot id: A0A3Q2UIJ3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:ADTRP
gene id: 9031:ADTRP
uniprot id: A0A1D5NVB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9031:ASF1A
gene id: 9031:ASF1A
uniprot id: Q3C1E9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. May also cooperate with HIRA to promote replication-independent chromatin assembly.
messages: Interacts with CHAF1B, HIRA, histone H3 and histone H4.
messages: Nucleus
messages: Phosphorylated.

9031:FMN1
gene id: 9031:FMN1
uniprot id: Q05858
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the formin homology family. Cappuccino subfamily.
messages: In the developing limb bud, the protein is expressed in the apical ectodermal ridge and the mesenchymal compartment, predominantly in the posterior region. During kidney morphogenesis, expression is initially restricted to the epithelial compartment of the pronephros and mesonephros.
messages: Is important for morphogenesis of limb and kidney and may be involved in determining dorsoventral neural tube polarity and motor neuron induction. It may also have a function in differentiated cells or be involved in maintaining specific differentiated states.
messages: Nucleus
messages: Present in the adult brain, kidney, brain, heart and intestine and throughout the embryo.

9031:ACSS1B
gene id: 9031:ACSS1B
uniprot id: E1BZT9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9031:FAIM2
gene id: 9031:FAIM2
uniprot id: A0A1D5PGL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9031:TMEM120A
gene id: 9031:TMEM120A
uniprot id: A0A1L1RMH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9031:PROX1
gene id: 9031:PROX1
uniprot id: F1P568
uniprot id: Q91018
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Prospero homeodomain family.
messages: Expressed most actively in the developing lens and midgut and at lower levels in the developing brain, heart, muscle and retina.
messages: First detected at stage 14 in the early lens placode. At later stages of development, it was observed throughout the lens, but it appeared more abundant around the bow region of the equator than in the anterior epithelium or the fibers. In the retina, expression was detected mainly in the inner nuclear layer during later stages of histogenesis.
messages: Nucleus
messages: The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
messages: Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes.

9031:TLR4
gene id: 9031:TLR4
uniprot id: C4PCF3
uniprot id: Q7ZTG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9031:TGFB2
gene id: 9031:TGFB2
uniprot id: F1NNP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9031:NDUFA2
gene id: 9031:NDUFA2
uniprot id: A0A1D5NVM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:SH3GL2
gene id: 9031:SH3GL2
uniprot id: Q8AXV1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface (By similarity).
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Early endosome
messages: Highly expressed in brain.
messages: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
messages: Membrane
messages: Monomer; in cytoplasm. Homodimer; when associated with membranes. Associates with MAP4K3. This interaction appears to regulate MAP4K3-mediated JNK activation (By similarity). Interacts with SYNJ1 and DNM1.
messages: Presynapse

9031:SFT2D2
gene id: 9031:SFT2D2
uniprot id: E1C211
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9031:MRPL23
gene id: 9031:MRPL23
uniprot id: Q7ZZB3
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

9031:PDE7A
gene id: 9031:PDE7A
uniprot id: A0A1D5P644
uniprot id: A0A1D5PU92
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:DYNLT3
gene id: 9031:DYNLT3
uniprot id: E1BVZ7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9031:CCDC47
gene id: 9031:CCDC47
uniprot id: F1NL71
names: Subcellular Location Annotation
messages: Membrane
messages: Rough endoplasmic reticulum membrane

9031:PIM1
gene id: 9031:PIM1
uniprot id: A0A1D5NZV7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9031:MARCO
gene id: 9031:MARCO
uniprot id: Q9I8D5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:KCNQ1
gene id: 9031:KCNQ1
uniprot id: A0A1D5PGY0
uniprot id: A0A3Q2U6I7
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft

9031:PYCR1
gene id: 9031:PYCR1
uniprot id: A0A1D5PKK0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9031:HBBR
gene id: 9031:HBBR
uniprot id: P02127
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The rho chain is the major early embryonic beta-type hemoglobin chain.

9031:HDLBP
gene id: 9031:HDLBP
uniprot id: E1C3A9
names: Subcellular Location Annotation
messages: Cytoplasm

9031:C3AR1L
gene id: 9031:C3AR1L
uniprot id: Q5ZIN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9031:LOC100858942
gene id: 9031:LOC100858942
uniprot id: C0J3M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9031:LOC418658
gene id: 9031:LOC418658
uniprot id: E1BYN0
uniprot id: F1NFL4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:TAT
gene id: 9031:TAT
uniprot id: E1C5G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

9031:PPP3R1
gene id: 9031:PPP3R1
uniprot id: Q6VN51
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9031:PARVG
gene id: 9031:PARVG
uniprot id: E1C888
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

9031:TAGLN3
gene id: 9031:TAGLN3
uniprot id: E1C7W7
names: Similarity
messages: Belongs to the calponin family.

9031:SLC37A3
gene id: 9031:SLC37A3
uniprot id: F1P289
uniprot id: Q5F3N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:UTP6
gene id: 9031:UTP6
uniprot id: F1NLG7
uniprot id: Q5ZI50
names: Similarity
messages: Belongs to the UTP6 family.

9031:TOP1MT
gene id: 9031:TOP1MT
uniprot id: A0A3Q2UPP2
uniprot id: Q6T722
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9031:IRX2
gene id: 9031:IRX2
uniprot id: Q9PU52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9031:PENK
gene id: 9031:PENK
uniprot id: E1C652
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

9031:CLIC5
gene id: 9031:CLIC5
uniprot id: A0A1D5PU60
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9031:SMC5
gene id: 9031:SMC5
uniprot id: F1NK20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

9031:EXOC2
gene id: 9031:EXOC2
uniprot id: F1P2A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

9031:SAMD8
gene id: 9031:SAMD8
uniprot id: F1NI82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9031:HOXD13
gene id: 9031:HOXD13
uniprot id: P24344
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Coordinately expressed in partially overlapping domains during wing development.
messages: Nucleus
messages: Sequence-specific transcription factor that binds gene promoters and activates their transcription (By similarity). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (PubMed:1672266).

9031:IFT46
gene id: 9031:IFT46
uniprot id: A0A1L1RRE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

9031:GABBR2
gene id: 9031:GABBR2
uniprot id: A0A1D5P1L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9031:ZBTB14
gene id: 9031:ZBTB14
uniprot id: Q92010
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Interacts with ZBTB21.
messages: Nucleus
messages: The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus.
messages: Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters (By similarity).

9031:CLDN10
gene id: 9031:CLDN10
uniprot id: E1C926
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:BLCAP
gene id: 9031:BLCAP
uniprot id: A0A3Q3ANJ1
names: Similarity
messages: Belongs to the BLCAP family.

9031:ZIC1
gene id: 9031:ZIC1
uniprot id: A0A1D5PND2
uniprot id: Q8JJC0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Expressed in dorsal undifferentiated neural cells in the spinal cord at stages 8 and 23 (at protein level). Expressed in the dorsal neural tube along almost the entire rostrocaudal extent and dorsomedial somites at stage 8. Expressed in the dorsal hindbrain, spinal cord, midbrain and forebrain at stage 17. Expressed in somites and the dorsal CNS at stage 23.
messages: Nucleus

9031:CERCAM
gene id: 9031:CERCAM
uniprot id: A0A3Q2U3E7
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

9031:MUSTN1
gene id: 9031:MUSTN1
uniprot id: Q76MS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: May be involved in the development and regeneration of the musculoskeletal system.
messages: Nucleus

9031:LOC100859427
gene id: 9031:LOC100859427
uniprot id: A0A3Q2UHL5
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:NR1H4
gene id: 9031:NR1H4
uniprot id: Q8JHU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

9031:CAND2
gene id: 9031:CAND2
uniprot id: E1BVC2
names: Similarity
messages: Belongs to the CAND family.

9031:ENTPD4
gene id: 9031:ENTPD4
uniprot id: E1C3V3
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9031:TPM1
gene id: 9031:TPM1
uniprot id: A0A1D5P342
uniprot id: A0A1L1RU52
uniprot id: A0A452J839
uniprot id: P04268
uniprot id: Q8AWI4
uniprot id: Q91005
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
messages: Homodimer (PubMed:23832280). Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG (PubMed:15269838, PubMed:15313924).
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

9031:HTR2B
gene id: 9031:HTR2B
uniprot id: F1NU82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9031:LRP8
gene id: 9031:LRP8
uniprot id: Q98931
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the LDLR family.
messages: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity).
messages: Homooligomer. Interacts with VLDLR. Reelin associates with two or more receptor molecules (By similarity). Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17 (By similarity). Interacts with PCSK9. Interacts with MDK; this interaction is calcium dependent (By similarity). Interacts with CLU (By similarity).
messages: Mainly in brain.
messages: Membrane
messages: O-glycosylated.
messages: Tyrosine phosphorylated upon apoE binding.

9031:B4GALTL
gene id: 9031:B4GALTL
uniprot id: A0A1L1RXH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:RAF1
gene id: 9031:RAF1
uniprot id: A0A452J7W6
uniprot id: P05625
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Isoform 1 was present in all tissues tested: skeletal muscle, intestine, brain, gizzard, heart, lung, kidney, bone marrow, spleen and bursa of Fabricius. Isoform 2 was only detected in brain, heart and skeletal muscle. In brain and heart isoform 1 is more abundant than isoform 2. In skeletal muscle isoform 2 is more abundant than isoform 1.
messages: Phosphorylation at Ser-259 inactivates kinase activity. Dephosphorylation of Ser-259 by a complex containing protein phosphatase 1 relieves inactivation, leading to stimulate RAF1 activity (By similarity).
messages: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity).

9031:KDM1A
gene id: 9031:KDM1A
uniprot id: A0A1D5P6W8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

9031:JAG2
gene id: 9031:JAG2
uniprot id: F1NMD6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9031:ZIC2
gene id: 9031:ZIC2
uniprot id: A0A1D5PNB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9031:SLC35B3
gene id: 9031:SLC35B3
uniprot id: F1P4W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9031:FGF10
gene id: 9031:FGF10
uniprot id: O42407
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:STX16
gene id: 9031:STX16
uniprot id: Q5ZK87
names: Similarity
messages: Belongs to the syntaxin family.

9031:MANEAL
gene id: 9031:MANEAL
uniprot id: E1BYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:PDLIM7
gene id: 9031:PDLIM7
uniprot id: Q679P3
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Anchored to cell periphery via its N-terminal PDZ domain.
messages: Expressed in the presumptive fore- and hindlimb. Continues to be expressed in the limb mesenchyme throughout forelimb and hindlimb bud outgrowth. Expressed in the developing heart and eye.
messages: Interacts with various PKC isoforms through the LIM zinc-binding domains. Interacts with TPM2 (By similarity). Interacts with TBX4 and TBX5.
messages: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. May be involved in bone formation (By similarity).
messages: The LIM zinc-binding 2 (LIM 2) interacts with TBX4.
messages: The LIM zinc-binding 3 (LIM 3) domain provides the structural basis for recognition of tyrosine-containing tight turn structures (By similarity). This domain is necessary and sufficient for interaction with TBX5.
messages: Z line
messages: cytoskeleton

9031:CHRNA8
gene id: 9031:CHRNA8
uniprot id: Q03481
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:SNCB
gene id: 9031:SNCB
uniprot id: Q9I9G9
names: Similarity
messages: Belongs to the synuclein family.

9031:KCTD7
gene id: 9031:KCTD7
uniprot id: Q5ZJP7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May be involved in the control of excitability of cortical neurons.
messages: cytosol

9031:IDH2
gene id: 9031:IDH2
uniprot id: Q5ZL82
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

9031:GPATCH11
gene id: 9031:GPATCH11
uniprot id: A0A1D5NZ97
names: Similarity
messages: Belongs to the GPATCH11 family.

9031:GSTA4
gene id: 9031:GSTA4
uniprot id: Q9W6J2
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9031:PLD4
gene id: 9031:PLD4
uniprot id: E1BVB3
names: Similarity
messages: Belongs to the phospholipase D family.

9031:SLC46A2
gene id: 9031:SLC46A2
uniprot id: R4GFI6
names: Subcellular Location Annotation
messages: Membrane

9031:TLR2A
gene id: 9031:TLR2A
uniprot id: C4PC57
uniprot id: Q9DD78
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Toll-like receptor family.
messages: Binds MYD88 (via TIR domain).
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Highly expressed in ovary. Detected at lower levels in heart, lung, gizzard and testis.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Membrane
messages: N-glycosylated. TLR2-1 is more heavily glycosylated than TLR2-2.
messages: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).

9031:ATP6V0A4
gene id: 9031:ATP6V0A4
uniprot id: A0A1D5PCU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9031:NKAPL
gene id: 9031:NKAPL
uniprot id: Q5ZIJ3
names: Similarity
messages: Belongs to the NKAP family.

9031:GABRP
gene id: 9031:GABRP
uniprot id: F1NY45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:CNOT6
gene id: 9031:CNOT6
uniprot id: A0A1D5P1T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9031:TNMD
gene id: 9031:TNMD
uniprot id: Q6YDP0
names: Similarity
messages: Belongs to the chondromodulin-1 family.

9031:CD74
gene id: 9031:CD74
uniprot id: Q6J613
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SHH
gene id: 9031:SHH
uniprot id: Q91035
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hedgehog family.
messages: Binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.
messages: By retinoic acid.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in the posterior limb bud mesenchyme, the Hensen node, the notochord, and the floor plate of the neural tube.
messages: First detectable at stage 17 during the initiation of limb bud formation. From that point onwards, the expression pattern exactly matches the location of the zone of polarizing activity (ZPA).
messages: Golgi apparatus membrane
messages: Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus (By similarity). Interacts with BOC and CDON (By similarity). Interacts with HHIP (By similarity). Interacts with DISP1 via its cholesterol anchor (By similarity). Interacts with SCUBE2 (By similarity).
messages: Multimer.
messages: N-palmitoylation by HHAT of ShhN is required for sonic hedgehog protein N-product multimerization and full activity (By similarity). It is a prerequisite for the membrane-proximal positioning and the subsequent shedding of this N-terminal peptide (By similarity).
messages: The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN) (By similarity). Cholesterylation is required for the sonic hedgehog protein N-product targeting to lipid rafts and multimerization (By similarity). ShhN is the active species in both local and long-range signaling, whereas the C-product (ShhC) is degraded in the reticulum endoplasmic (By similarity).
messages: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).
messages: The Cardin-Weintraub (CW) motif is required for heparan sulfate binding of the solubilized ShhNp (By similarity). The N-terminal palmitoylated peptide is cleaved at the Heparan sulfate-binding Cardin-Weintraub (CW) motif site (By similarity). The cleavage reduced the interactions with heparan sulfate. The cleavage is enhanced by SCUBE2 (By similarity).
messages: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:7736596). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (By similarity).
messages: The lipidated N- and C-terminal peptides of ShhNp can be cleaved (shedding) (By similarity). The N-terminal palmitoylated peptide is cleaved at the Cardin-Weintraub (CW) motif site (By similarity). The cleavage reduced the interactions with heparan sulfate (By similarity). The cleavage is enhanced by SCUBE2 (By similarity).
messages: The several steps and mechanisms that permit controlled Shh dispersion and gradient formation remain controversial. The ShhNC C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity resulting in the cleavage and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (ShhN). The protein is further modified by covalent addition of palmitate at the N-terminal of ShhN, resulting to the dual-lipidated Shh (ShhNp). ShhNp is firmly tethered to the cell membrane where it forms multimers. Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by proteolytic removal of both terminal lipidated peptides. Once released, the fully processed Shh can signal within embryonic tissues both at short and long-range.

9031:RNF5
gene id: 9031:RNF5
uniprot id: Q5ZIR9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.

9031:MTMR10
gene id: 9031:MTMR10
uniprot id: A0A3Q2TXM8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9031:SOX8
gene id: 9031:SOX8
uniprot id: P57074
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.
messages: Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
messages: Widely expressed in the embryo.

9031:SMS
gene id: 9031:SMS
uniprot id: Q5F3Z6
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9031:SUDS3
gene id: 9031:SUDS3
uniprot id: Q5ZHZ8
names: Subcellular Location Annotation
messages: Nucleus

9031:YME1L1
gene id: 9031:YME1L1
uniprot id: Q5ZIG8
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9031:RFX2
gene id: 9031:RFX2
uniprot id: E1BSB3
names: Subcellular Location Annotation
messages: Nucleus

9031:GPN3
gene id: 9031:GPN3
uniprot id: A0A1L1RYU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9031:CCR5
gene id: 9031:CCR5
uniprot id: B2BJC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:MINAR1
gene id: 9031:MINAR1
uniprot id: Q5Y1E8
names: Similarity
messages: Belongs to the MINAR family.

9031:LOC121106470
gene id: 9031:LOC121106470
uniprot id: A0A1D5P5R1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9031:AvBD5
gene id: 9031:AvBD5
uniprot id: Q6IV26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Has bactericidal activity.
messages: Secreted
messages: Strong expression in the tongue and bone marrow. Low expression in the esophagus, trachea, lung, brain and ovary. Expressed in the ovarian stroma, but not in the ovarian follicles.

9031:FAM188A
gene id: 9031:FAM188A
uniprot id: A0A1L1RPT9
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9031:DYNC1I1
gene id: 9031:DYNC1I1
uniprot id: A0A1D5PCH6
uniprot id: E1C7N2
names: Similarity
messages: Belongs to the dynein intermediate chain family.

9031:RNF111
gene id: 9031:RNF111
uniprot id: F1P2A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

9031:CD5
gene id: 9031:CD5
uniprot id: O73906
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:MINOS1
gene id: 9031:MINOS1
uniprot id: F1NWZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9031:SLBP
gene id: 9031:SLBP
uniprot id: Q6B7Z7
names: Similarity
messages: Belongs to the SLBP family.

9031:ADAMTS8
gene id: 9031:ADAMTS8
uniprot id: A0A1D5PVG5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:SCN4A
gene id: 9031:SCN4A
uniprot id: F9W2X7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9031:ATF4
gene id: 9031:ATF4
uniprot id: Q9W610
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

9031:CNDP1
gene id: 9031:CNDP1
uniprot id: F1P464
names: Cofactor
messages: Binds 2 manganese ions per subunit.

9031:CCNI
gene id: 9031:CCNI
uniprot id: F1P1K0
names: Similarity
messages: Belongs to the cyclin family.

9031:PLEKHO1
gene id: 9031:PLEKHO1
uniprot id: A0A1D5P4V8
uniprot id: Q5F3C8
names: Function
names: PTM
names: Subcellular Location Annotation
messages: C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.
messages: Cytoplasm
messages: Membrane
messages: Nucleus
messages: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).

9031:PFKFB4
gene id: 9031:PFKFB4
uniprot id: A0A1D5P252
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9031:PCYOX1
gene id: 9031:PCYOX1
uniprot id: F1NYT7
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9031:POLG
gene id: 9031:POLG
uniprot id: A0A1L1RT70
names: Function
names: Subcellular Location Annotation
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

9031:XYLT1
gene id: 9031:XYLT1
uniprot id: A0A1D5NUI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

9031:OXCT1
gene id: 9031:OXCT1
uniprot id: Q5F3M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

9031:NMS
gene id: 9031:NMS
uniprot id: A0A2I6J485
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9031:BLOC1S6
gene id: 9031:BLOC1S6
uniprot id: Q5ZIM2
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9031:NOBOX
gene id: 9031:NOBOX
uniprot id: A0A3Q2U9C5
names: Subcellular Location Annotation
messages: Nucleus

9031:ATR
gene id: 9031:ATR
uniprot id: F1NGW1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

9031:ST3GAL3
gene id: 9031:ST3GAL3
uniprot id: A0A1D5PQ75
uniprot id: F1P2W7
uniprot id: I6WCL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:PRKD1
gene id: 9031:PRKD1
uniprot id: F1NHL1
uniprot id: Q5F3M9
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9031:NAPRT
gene id: 9031:NAPRT
uniprot id: A0A1D5PSP4
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

9031:IRF4
gene id: 9031:IRF4
uniprot id: Q98TX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:LOC101750517
gene id: 9031:LOC101750517
uniprot id: F1NPX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

9031:TRPV1
gene id: 9031:TRPV1
uniprot id: Q8QFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendritic spine membrane

9031:PLAU
gene id: 9031:PLAU
uniprot id: F1NYX5
uniprot id: P15120
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

9031:MRPL42
gene id: 9031:MRPL42
uniprot id: F1NWY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

9031:TERF1
gene id: 9031:TERF1
uniprot id: Q5F3M6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus

9031:ANK1
gene id: 9031:ANK1
uniprot id: A0A3Q2U1V0
uniprot id: A0A3Q2UAG0
uniprot id: A0A3Q2UDZ7
uniprot id: A0A3Q3AKQ1
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9031:ABLIM2
gene id: 9031:ABLIM2
uniprot id: A0A3Q3AZY7
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ST8SIA6
gene id: 9031:ST8SIA6
uniprot id: Q6ZXC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:FAM105A
gene id: 9031:FAM105A
uniprot id: A0A1D5P7Q1
uniprot id: A0A1D5PWB5
uniprot id: F1NNA2
uniprot id: Q5ZK68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9031:MMP23A
gene id: 9031:MMP23A
uniprot id: E1BX58
names: Caution
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GDPD5
gene id: 9031:GDPD5
uniprot id: A0A1D5NU41
uniprot id: A0A1D5PB53
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:TOMM7
gene id: 9031:TOMM7
uniprot id: A0A1L1RYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:TGFBR2L
gene id: 9031:TGFBR2L
uniprot id: E1BQF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: Membrane raft

9031:HSDL1
gene id: 9031:HSDL1
uniprot id: Q5ZJG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: May catalyze the metabolism of steroid hormones and thus play an important role in sex differentiation, the emergence and maintenance of the secondary sexual characters, and the regulation of endocrine.
messages: Mitochondrion

9031:LOC426218
gene id: 9031:LOC426218
uniprot id: H9L096
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:DOK6
gene id: 9031:DOK6
uniprot id: F1P215
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9031:ZAP70
gene id: 9031:ZAP70
uniprot id: E1BU42
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9031:TEKT2
gene id: 9031:TEKT2
uniprot id: E1C1A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

9031:PARP4
gene id: 9031:PARP4
uniprot id: A0A1D5PL17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

9031:ETV5
gene id: 9031:ETV5
uniprot id: F1NEG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:GATSL2
gene id: 9031:GATSL2
uniprot id: A0A1D5PUZ4
names: Similarity
messages: Belongs to the GATS family.

9031:PNLIPRP1
gene id: 9031:PNLIPRP1
uniprot id: F1P5K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9031:NMNAT2
gene id: 9031:NMNAT2
uniprot id: E1BXJ1
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9031:KIF21A
gene id: 9031:KIF21A
uniprot id: A0A1D5P9A9
uniprot id: A0A1D5PRV0
uniprot id: E1C7L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

9031:RIOK2
gene id: 9031:RIOK2
uniprot id: F1NNG4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9031:PSMA7
gene id: 9031:PSMA7
uniprot id: O13268
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Interacts with HIF1A. Interacts with RAB7A. Interacts with PRKN. Interacts with ABL1 and ABL2. Interacts with EMAP2. Interacts with MAVS.

9031:CHM
gene id: 9031:CHM
uniprot id: Q5ZKN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9031:AvBD3
gene id: 9031:AvBD3
uniprot id: Q9DG58
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Expression in cultured vaginal cells is increased by LPS and S.enteritidis.
messages: Has bactericidal activity.
messages: In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens.
messages: Secreted
messages: Strongly expressed in the tongue, bone marrow, bursa of Fabricius and trachea. Also expressed in skin, esophagus and air sacs. Weak expression in the large intestine, kidney and ovary. Expressed in the vagina and ovarian stroma, but not in the ovarian follicle.

9031:ALDOB
gene id: 9031:ALDOB
uniprot id: P07341
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Homotetramer.
messages: In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
messages: centriolar satellite

9031:BBS7
gene id: 9031:BBS7
uniprot id: E1BXI4
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9031:STRA6
gene id: 9031:STRA6
uniprot id: F1NSC4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:LOC107049146
gene id: 9031:LOC107049146
uniprot id: A0A1D5P9Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:SSR3
gene id: 9031:SSR3
uniprot id: R4GJK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

9031:MEP1B
gene id: 9031:MEP1B
uniprot id: A0A1L1RS59
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:BCL2A1
gene id: 9031:BCL2A1
uniprot id: Q9W6F2
names: Similarity
messages: Belongs to the Bcl-2 family.

9031:LSM14B
gene id: 9031:LSM14B
uniprot id: A0A1D5PS81
uniprot id: F1NWM9
names: Similarity
messages: Belongs to the LSM14 family.

9031:TERF2IP
gene id: 9031:TERF2IP
uniprot id: Q7T0L4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity).
messages: Belongs to the RAP1 family.
messages: Homodimer. Component of the shelterin complex (telosome) (By similarity). Interacts with terf2; the interaction is direct.
messages: Nucleus
messages: Shares a bidirectional promoter with KARS.
messages: telomere

9031:GPR83L
gene id: 9031:GPR83L
uniprot id: F8UV75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:ITGA9
gene id: 9031:ITGA9
uniprot id: Q5ZM22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9031:TMEM183A
gene id: 9031:TMEM183A
uniprot id: A0A1D5PNU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

9031:CLIC3
gene id: 9031:CLIC3
uniprot id: A0A1D5PD90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

9031:SQSTM1
gene id: 9031:SQSTM1
uniprot id: A0A1D5PLN4
uniprot id: A0A1D5PXQ2
names: Subcellular Location Annotation
messages: autophagosome

9031:MINA
gene id: 9031:MINA
uniprot id: Q5ZJC5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
messages: nucleolus

9031:LOC424199
gene id: 9031:LOC424199
uniprot id: A0A3Q2UCI8
names: Similarity
messages: Belongs to the apolipoprotein L family.

9031:C5H14orf4
gene id: 9031:C5H14orf4
uniprot id: A0A1D5NX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9031:RAB10
gene id: 9031:RAB10
uniprot id: Q5ZIT5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Also plays a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. Finally, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (By similarity).
messages: cilium
messages: perinuclear region
messages: phagosome membrane
messages: trans-Golgi network membrane

9031:COPS9
gene id: 9031:COPS9
uniprot id: A0A3Q2UDI0
names: Similarity
messages: Belongs to the CSN9 family.

9031:TPX2
gene id: 9031:TPX2
uniprot id: F1NW64
uniprot id: Q805A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9031:CYP2W1
gene id: 9031:CYP2W1
uniprot id: E1C495
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:KCNA2
gene id: 9031:KCNA2
uniprot id: Q7T1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane

9031:CBL
gene id: 9031:CBL
uniprot id: Q98TY6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9031:KDELR2
gene id: 9031:KDELR2
uniprot id: Q5ZKX9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (PubMed:30846601). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (PubMed:30846601).

9031:FUT7
gene id: 9031:FUT7
uniprot id: Q8UWB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9031:PPP6R2
gene id: 9031:PPP6R2
uniprot id: A0A1D5P3R3
names: Similarity
messages: Belongs to the SAPS family.

9031:SESN1
gene id: 9031:SESN1
uniprot id: A0A1D5P711
uniprot id: A0A1D5PK02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9031:CLDN20
gene id: 9031:CLDN20
uniprot id: A0A3Q3ANS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:TMEM43
gene id: 9031:TMEM43
uniprot id: E1BUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9031:AURKB
gene id: 9031:AURKB
uniprot id: E1BVE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9031:ELAVL1
gene id: 9031:ELAVL1
uniprot id: Q9PW24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

9031:CHRM2
gene id: 9031:CHRM2
uniprot id: P30372
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
messages: Cell membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
messages: This receptor has a high affinity for pirenzepine.

9031:NOL6
gene id: 9031:NOL6
uniprot id: A0A1D5PT04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

9031:BLM
gene id: 9031:BLM
uniprot id: Q9I920
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:28228481). Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair (By similarity). Negatively regulates sister chromatid exchange (SCE) (By similarity). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity). Binds DNA (PubMed:28228481). Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity).
messages: Belongs to the helicase family. RecQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer (PubMed:28228481). Homodimer (via N-terminus) (PubMed:28228481). Homotetramer (via N-terminus); dimer of dimers (PubMed:28228481). Homohexamer (via N-terminus) (PubMed:28228481). Self-association negatively regulates DNA unwinding amplitude and rate (PubMed:28228481). Oligomer complexes dissociate into monomer in presence of ATP (PubMed:28228481).
messages: Nucleus
messages: The N-terminal region mediates dimerization and homooligomerization (PubMed:28228481). Both the helicase ATP-binding domain and the helicase C-terminal domain form intramolecular interactions with the HRDC domain in a ATP-dependent manner (By similarity). The HRDC domain is required for single-stranded DNA (ssDNA) and DNA Holliday junction binding (By similarity).

9031:TMPO
gene id: 9031:TMPO
uniprot id: A0A1L1RX46
uniprot id: A0A3Q2UJ35
uniprot id: Q5ZMN6
names: Similarity
messages: Belongs to the LEM family.

9031:ING2
gene id: 9031:ING2
uniprot id: A0A3Q2UH22
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9031:KATNB1
gene id: 9031:KATNB1
uniprot id: Q5ZIU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

9031:UNC45B
gene id: 9031:UNC45B
uniprot id: F1NVB3
names: Subcellular Location Annotation
messages: A band
messages: Z line
messages: perinuclear region

9031:FUCA1
gene id: 9031:FUCA1
uniprot id: F1P4X3
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9031:ENS-3
gene id: 9031:ENS-3
uniprot id: Q98ST1
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

9031:NTRK2
gene id: 9031:NTRK2
uniprot id: Q91987
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Detected in embryonic brain and orsal root ganglia.
messages: Endosome membrane
messages: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor (By similarity). Interacts with SORCS2; this interaction is important for normal targeting to post-synaptic densities in response to high-frequency stimulation (By similarity). Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway (By similarity). Interacts with APPL1 (By similarity). Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (By similarity).
messages: It is unsure whether Leu-144 or Met-188 is the initiator of isoform 2.
messages: Ligand-mediated auto-phosphorylation.
messages: Postsynaptic density
messages: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4 (PubMed:8287802, PubMed:8670834). Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:8670834). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia (By similarity).
messages: Specifically activated by BDNF but not NTF3 and NTF4.
messages: The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity).
messages: axon
messages: dendrite
messages: perinuclear region

9031:CMC2
gene id: 9031:CMC2
uniprot id: A0A1D5PD00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9031:TOB1
gene id: 9031:TOB1
uniprot id: Q90VW0
names: Similarity
messages: Belongs to the BTG family.

9031:SLC25A38
gene id: 9031:SLC25A38
uniprot id: A0A1D5P6J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane

9031:GALT
gene id: 9031:GALT
uniprot id: R4GFF0
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

9031:PLSCR5
gene id: 9031:PLSCR5
uniprot id: E1C858
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9031:YPEL2
gene id: 9031:YPEL2
uniprot id: Q5ZI07
names: Similarity
messages: Belongs to the yippee family.

9031:ORC5
gene id: 9031:ORC5
uniprot id: Q5F3H9
names: Subcellular Location Annotation
messages: Nucleus

9031:SOX11
gene id: 9031:SOX11
uniprot id: P48435
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expression is maximal at stages 24-31, then begins to decline. Expression is low by stage 37 and disappears by stage 39. Does not appear to be expressed in adults.
messages: Low level expression is seen in undifferentiated proliferating cells of the neural epithelium. Greater expression is seen in the maturing neurons after they leave the neural epithelium. Also expressed in the embryonic gut epithelium and adrenal medulla.
messages: Nucleus
messages: Transcription factor that acts as a transcriptional activator (By similarity). May function as a switch in neuronal development (PubMed:7748786).

9031:ATP1B1
gene id: 9031:ATP1B1
uniprot id: P08251
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

9031:ANAPC1
gene id: 9031:ANAPC1
uniprot id: A0A3Q2TZ07
uniprot id: A0A3Q2UIV9
names: Function
names: Similarity
messages: Belongs to the APC1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9031:LOC395159
gene id: 9031:LOC395159
uniprot id: Q6TPK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SLC25A13
gene id: 9031:SLC25A13
uniprot id: Q5ZIF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9031:HIST1H2B7
gene id: 9031:HIST1H2B7
uniprot id: P0C1H3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct.
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:SMAGP
gene id: 9031:SMAGP
uniprot id: A0A1D5P4L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

9031:DHRS7B
gene id: 9031:DHRS7B
uniprot id: A0A3Q2UBH5
uniprot id: F1NH35
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:TM6SF1
gene id: 9031:TM6SF1
uniprot id: A0A1L1RWK0
names: Subcellular Location Annotation
messages: Membrane

9031:WFDC1
gene id: 9031:WFDC1
uniprot id: Q8JG33
names: Function
names: Subcellular Location Annotation
messages: Has growth inhibitory activity.
messages: Secreted

9031:B3GNT2
gene id: 9031:B3GNT2
uniprot id: Q5ZK57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:CDH18
gene id: 9031:CDH18
uniprot id: A0A1D5PKP1
uniprot id: A0A1D5PZT9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9031:ADRA1B
gene id: 9031:ADRA1B
uniprot id: A0A6J3ZXA9
uniprot id: F1NIZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

9031:BCLAF1
gene id: 9031:BCLAF1
uniprot id: A0A1D5NWG1
uniprot id: A0A1D5PC74
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9031:TTC27
gene id: 9031:TTC27
uniprot id: Q5F3K0
names: Similarity
messages: Belongs to the TTC27 family.

9031:PTGES3
gene id: 9031:PTGES3
uniprot id: Q90955
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Binds to telomerase (By similarity). Binds to the progesterone receptor (PubMed:8114727).
messages: Cytoplasm
messages: Molecular chaperone.

9031:PANX3
gene id: 9031:PANX3
uniprot id: E1C4Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9031:CLUH
gene id: 9031:CLUH
uniprot id: F1N988
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

9031:NEK6
gene id: 9031:NEK6
uniprot id: Q5F3L5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:ARHGEF18
gene id: 9031:ARHGEF18
uniprot id: A0A1D5PC02
uniprot id: F1NJU1
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ASPHD1
gene id: 9031:ASPHD1
uniprot id: E1BSD3
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9031:PYGB
gene id: 9031:PYGB
uniprot id: Q5ZME4
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9031:HYLS1
gene id: 9031:HYLS1
uniprot id: A0A1D5NVB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9031:UBE2D3
gene id: 9031:UBE2D3
uniprot id: Q5ZL59
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:ARHGEF7
gene id: 9031:ARHGEF7
uniprot id: A0A3Q2TT34
uniprot id: A0A3Q2TZR1
uniprot id: A0A3Q3API9
names: Subcellular Location Annotation
messages: lamellipodium

9031:PALMD
gene id: 9031:PALMD
uniprot id: E1C6E8
names: Similarity
messages: Belongs to the paralemmin family.

9031:ZBTB7A
gene id: 9031:ZBTB7A
uniprot id: O93567
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ and in alternative splicing (By similarity).

9031:RXFP2
gene id: 9031:RXFP2
uniprot id: A0A1D5P7S6
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:PNPLA4
gene id: 9031:PNPLA4
uniprot id: B3TZB7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SDF4
gene id: 9031:SDF4
uniprot id: Q5ZKE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen
messages: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.

9031:GOLM1
gene id: 9031:GOLM1
uniprot id: E1C3N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9031:DYNLL1
gene id: 9031:DYNLL1
uniprot id: F1N8L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9031:TMEM106B
gene id: 9031:TMEM106B
uniprot id: A0A1D5PUI5
uniprot id: Q5F3Z0
names: Similarity
messages: Belongs to the TMEM106 family.

9031:LOC395991
gene id: 9031:LOC395991
uniprot id: O42397
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PPP1R16B
gene id: 9031:PPP1R16B
uniprot id: Q5ZHY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:CORIN
gene id: 9031:CORIN
uniprot id: F1NZW6
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:FABP4
gene id: 9031:FABP4
uniprot id: Q90X55
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:MTTPL
gene id: 9031:MTTPL
uniprot id: F1NPK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TPD52
gene id: 9031:TPD52
uniprot id: Q5ZHP4
names: Similarity
messages: Belongs to the TPD52 family.

9031:HSPD1
gene id: 9031:HSPD1
uniprot id: Q5ZL72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chaperonin (HSP60) family.
messages: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.
messages: Mitochondrion matrix

9031:SLC25A37
gene id: 9031:SLC25A37
uniprot id: F1NS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:PTMA
gene id: 9031:PTMA
uniprot id: A0A1D5PPP9
names: Similarity
messages: Belongs to the pro/parathymosin family.

9031:ERGIC2
gene id: 9031:ERGIC2
uniprot id: E1C3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9031:ADGRL2
gene id: 9031:ADGRL2
uniprot id: A0A1D5PBF0
names: Subcellular Location Annotation
messages: Membrane

9031:PDK4
gene id: 9031:PDK4
uniprot id: F1NYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9031:PPARA
gene id: 9031:PPARA
uniprot id: A0A1D5PJQ2
uniprot id: Q9I8W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9031:NEMF
gene id: 9031:NEMF
uniprot id: F1N8T0
names: Similarity
messages: Belongs to the NEMF family.

9031:ACAA2
gene id: 9031:ACAA2
uniprot id: Q5ZLW8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9031:CMBL
gene id: 9031:CMBL
uniprot id: E1BXS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9031:SPIA4
gene id: 9031:SPIA4
uniprot id: A0A160F7C1
uniprot id: E1BS56
names: Similarity
messages: Belongs to the serpin family.

9031:GPR155
gene id: 9031:GPR155
uniprot id: F1NXA3
names: Subcellular Location Annotation
messages: Membrane

9031:FZR1
gene id: 9031:FZR1
uniprot id: H9L1Y1
uniprot id: Q8UWJ7
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9031:MYO1G
gene id: 9031:MYO1G
uniprot id: Q5ZMC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cell membrane
messages: Interacts with calmodulin; via its IQ motifs.
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).
messages: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication.
messages: phagocytic cup

9031:CTGFL
gene id: 9031:CTGFL
uniprot id: A0A1D5NYX5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:PM20D2
gene id: 9031:PM20D2
uniprot id: F1P3U4
names: Similarity
messages: Belongs to the peptidase M20A family.

9031:STIM1
gene id: 9031:STIM1
uniprot id: Q5ZIJ6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:CPNE1
gene id: 9031:CPNE1
uniprot id: F1NKY6
names: Similarity
messages: Belongs to the copine family.

9031:FHIP1B
gene id: 9031:FHIP1B
uniprot id: A0A3Q2TUN0
uniprot id: F1NSN2
names: Similarity
messages: Belongs to the FHIP family.

9031:C11orf70
gene id: 9031:C11orf70
uniprot id: E1C9D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9031:ATP5I
gene id: 9031:ATP5I
uniprot id: Q9YH14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

9031:SYS1
gene id: 9031:SYS1
uniprot id: E1C467
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

9031:AKR1B10
gene id: 9031:AKR1B10
uniprot id: Q90W83
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9031:UTS2RL
gene id: 9031:UTS2RL
uniprot id: F1NDY4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:SEC23A
gene id: 9031:SEC23A
uniprot id: A0A1D5P0E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9031:SPCS3
gene id: 9031:SPCS3
uniprot id: P28687
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SPCS3 family.
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit SEC11A and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:2831945). Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit SEC11C and three accessory subunits SPCS1, SPCS2 and SPCS3 (PubMed:2831945). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity).
messages: Endoplasmic reticulum membrane
messages: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).
messages: Expressed in hen oviduct (at protein level).

9031:RDH16
gene id: 9031:RDH16
uniprot id: A0A1D5P648
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:RPS10
gene id: 9031:RPS10
uniprot id: E1C4N0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9031:SGTA
gene id: 9031:SGTA
uniprot id: A0A1D5PBJ5
uniprot id: Q5ZHW6
names: Similarity
messages: Belongs to the SGT family.

9031:PSMB4
gene id: 9031:PSMB4
uniprot id: H9L0U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

9031:HDC
gene id: 9031:HDC
uniprot id: F1NXM1
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9031:BECN1
gene id: 9031:BECN1
uniprot id: Q5ZKS6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beclin family.
messages: Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: May be proteolytically processed by caspases; the C-terminal fragment(s) may induce apoptosis.
messages: Mitochondrion membrane
messages: Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity).
messages: autophagosome
messages: trans-Golgi network membrane

9031:FAM210A
gene id: 9031:FAM210A
uniprot id: Q5ZML6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM210 family.
messages: Cytoplasm
messages: Interacts with ATAD3A.
messages: May play a role in the structure and strength of both muscle and bone.
messages: Membrane
messages: Mitochondrion

9031:RHPN1
gene id: 9031:RHPN1
uniprot id: A0A1D5NTA2
names: Similarity
messages: Belongs to the RHPN family.

9031:KIF5B
gene id: 9031:KIF5B
uniprot id: E1C3A1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:ENAH
gene id: 9031:ENAH
uniprot id: O93263
uniprot id: Q90YB5
uniprot id: Q9DEG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

9031:HBE
gene id: 9031:HBE
uniprot id: P02128
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Beta-type chain found in early embryos.
messages: Heterotetramer of two epsilon chains and two alpha chains. Hemoglobin E (Hbe) contains a alpha-A chains while hemoglobin M (Hbm) contains alpha-D chains.

9031:HBAD
gene id: 9031:HBAD
uniprot id: P02001
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha-D chains and two beta chains. The component D forms dimers of tetramers upon deoxygenation.
messages: In birds, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.
messages: Ref.6 chain was isolated from Hbm, the least abundant of the four early chick hemoglobins.

9031:CDH15
gene id: 9031:CDH15
uniprot id: A0A1D5P5J3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9031:LOC431323
gene id: 9031:LOC431323
uniprot id: A0A1D5NWU6
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:CCDC50
gene id: 9031:CCDC50
uniprot id: Q5ZM86
names: Function
names: PTM
messages: Involved in EGFR signaling.
messages: Phosphorylated on tyrosine residues.

9031:PITX2
gene id: 9031:PITX2
uniprot id: O93385
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis.
messages: Nucleus

9031:CHAF1B
gene id: 9031:CHAF1B
uniprot id: F1P2D7
uniprot id: Q5R1S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat HIR1 family.
messages: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
messages: Interacts with CHAF1A.
messages: Nucleus

9031:ITM2C
gene id: 9031:ITM2C
uniprot id: A0A1D5P5B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9031:HIST1H103
gene id: 9031:HIST1H103
uniprot id: P08285
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

9031:GOSR2
gene id: 9031:GOSR2
uniprot id: A0A3Q3AE10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9031:LOC431316
gene id: 9031:LOC431316
uniprot id: A0A1D5PAN7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:PCDHAC1
gene id: 9031:PCDHAC1
uniprot id: Q6R0H9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:P3H1
gene id: 9031:P3H1
uniprot id: Q6JHU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the leprecan family.
messages: Binds unfolded collagen in a complex with CYPB and CRTAP.
messages: Endoplasmic reticulum
messages: Expressed in embryonic dermis, tendon, cartilage, liver and kidney. Expression in the kidney is restricted to the calyx. In the liver, expression is restricted to the interlobular septum.
messages: Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types IV and V. May be involved in the secretoty pathway of cells. Has growth suppressive activity in fibroblasts.

9031:MED7
gene id: 9031:MED7
uniprot id: E1C6N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

9031:KIF1B
gene id: 9031:KIF1B
uniprot id: A0A3Q2UDS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

9031:LRRC45
gene id: 9031:LRRC45
uniprot id: Q5ZI11
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.
messages: Homomer.
messages: centrosome

9031:GALNTL6
gene id: 9031:GALNTL6
uniprot id: A0A1D5PUA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:GLIS1
gene id: 9031:GLIS1
uniprot id: F1ND41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

9031:UBE2E1
gene id: 9031:UBE2E1
uniprot id: F1P120
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:SELENOT
gene id: 9031:SELENOT
uniprot id: Q5ZJN8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.
messages: Endoplasmic reticulum membrane
messages: May contain a selenide-sulfide bond between Cys-50 and Sec-53. This bond is speculated to serve as redox-active pair (By similarity).
messages: Selenoprotein with thioredoxin reductase-like oxidoreductase activity.

9031:NUTF2
gene id: 9031:NUTF2
uniprot id: F1NLL4
uniprot id: Q5ZLY4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9031:LOC100857280
gene id: 9031:LOC100857280
uniprot id: A0A3Q3AT56
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9031:PRDM5
gene id: 9031:PRDM5
uniprot id: E1BV09
names: Subcellular Location Annotation
messages: Nucleus

9031:ADRA1A
gene id: 9031:ADRA1A
uniprot id: F1NP52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

9031:CHGA
gene id: 9031:CHGA
uniprot id: F1NLZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

9031:TMSB4Y
gene id: 9031:TMSB4Y
uniprot id: A0A3Q2UAP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9031:UBE4B
gene id: 9031:UBE4B
uniprot id: A0A1D5P1D5
uniprot id: F1NGY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

9031:ITGB2
gene id: 9031:ITGB2
uniprot id: Q92070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

9031:NRCAM
gene id: 9031:NRCAM
uniprot id: P35331
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Cell membrane
messages: Expressed in developing neural retina and embryonic brain tissue.
messages: Heterodimer of an alpha and a beta chain.
messages: Retina and developing brain.
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Specifically involved in the development of optic fibres in the retina.

9031:MYBPHL
gene id: 9031:MYBPHL
uniprot id: Q05623
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. MyBP family.
messages: Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
messages: Skeletal muscle. Seems to be also expressed in the slow tonic ald muscle. Not detected in gizzard or heart.

9031:OTUB1
gene id: 9031:OTUB1
uniprot id: A0A1D5NTA0
names: Similarity
messages: Belongs to the peptidase C65 family.

9031:CCT6A
gene id: 9031:CCT6A
uniprot id: Q5ZJ54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity).
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

9031:ITGA8
gene id: 9031:ITGA8
uniprot id: A0A1D5PM20
uniprot id: P26009
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the integrin alpha chain family.
messages: Cell membrane
messages: Expressed in developing tectum (at protein level).
messages: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.
messages: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
messages: Membrane
messages: Prominently expressed on axons and on cells in contact with basal laminae in embryos.

9031:VPS25
gene id: 9031:VPS25
uniprot id: A0A1D5NW43
names: Similarity
messages: Belongs to the VPS25 family.

9031:TSPAN2
gene id: 9031:TSPAN2
uniprot id: E1C2R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:DDX5
gene id: 9031:DDX5
uniprot id: A0A3S5ZPN3
uniprot id: Q9W744
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9031:MAP3K7
gene id: 9031:MAP3K7
uniprot id: A0A1D5NUC4
uniprot id: A0A1D5PAV9
uniprot id: E1C063
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9031:C6
gene id: 9031:C6
uniprot id: B8ZX71
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:PCM1
gene id: 9031:PCM1
uniprot id: Q8AV28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PCM1 family.
messages: Cytoplasmic granule
messages: Required for centrosome assembly and function (PubMed:12403812). Essential for the correct localization of several centrosomal proteins including CETN3 and PCNT (By similarity). Required to anchor microtubules to the centrosome (PubMed:12403812). Probably involved in the biogenesis of cilia (By similarity).
messages: Self-associates.
messages: centriolar satellite
messages: centrosome
messages: cilium basal body
messages: cytoskeleton

9031:DNAJC18
gene id: 9031:DNAJC18
uniprot id: E1C5R7
names: Subcellular Location Annotation
messages: Membrane

9031:SMIM12
gene id: 9031:SMIM12
uniprot id: A0A1D5PAL1
names: Similarity
messages: Belongs to the SMIM12 family.

9031:LOC426913
gene id: 9031:LOC426913
uniprot id: R4GKP9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:CFAP43
gene id: 9031:CFAP43
uniprot id: A0A3Q3AYK8
names: Similarity
messages: Belongs to the CFAP43 family.

9031:NFX1
gene id: 9031:NFX1
uniprot id: A0A1D5P8E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9031:CLIC4
gene id: 9031:CLIC4
uniprot id: F1NYZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

9031:COQ10A
gene id: 9031:COQ10A
uniprot id: A0A1D5P181
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9031:CREB1
gene id: 9031:CREB1
uniprot id: Q7SX83
names: Subcellular Location Annotation
messages: Nucleus

9031:F-KER
gene id: 9031:F-KER
uniprot id: R4GIF9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:TTLL1
gene id: 9031:TTLL1
uniprot id: A0A3Q3AZU2
uniprot id: F1NZA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin polyglutamylase family.
messages: cilium basal body

9031:MARK3
gene id: 9031:MARK3
uniprot id: A0A3Q2U0C1
uniprot id: A0A3Q2UAK5
uniprot id: A0A3Q3A6W5
uniprot id: A0A3Q3AMF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9031:CLCN1
gene id: 9031:CLCN1
uniprot id: F1NAL0
names: Subcellular Location Annotation
messages: Membrane

9031:FHL5
gene id: 9031:FHL5
uniprot id: E1C1I0
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9031:INTS12
gene id: 9031:INTS12
uniprot id: E1C843
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 12 family.
messages: Nucleus

9031:SLC10A7
gene id: 9031:SLC10A7
uniprot id: E1BU54
uniprot id: Q5ZJH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates.

9031:C6orf89
gene id: 9031:C6orf89
uniprot id: Q5F344
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9031:SLC17A5
gene id: 9031:SLC17A5
uniprot id: A0A3Q2U392
uniprot id: Q5ZL94
names: Subcellular Location Annotation
messages: Membrane

9031:CHMP4B
gene id: 9031:CHMP4B
uniprot id: Q5ZHP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Late endosome membrane
messages: Midbody
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).
messages: cytosol

9031:PTP4A1
gene id: 9031:PTP4A1
uniprot id: Q5ZIQ1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9031:IFNW1
gene id: 9031:IFNW1
uniprot id: Q90873
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:HPCAL1
gene id: 9031:HPCAL1
uniprot id: P42324
names: Induction
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the recoverin family.
messages: By the MYB-ETS fusion oncogene.
messages: Expressed in hemopoietic cells, but also in the fibroblasts, bone marrow, brain, eye and gut.
messages: Probably binds two or three calcium ions.

9031:MDM4
gene id: 9031:MDM4
uniprot id: A0A3Q2TVB9
uniprot id: A0A3Q3AAH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

9031:HNRNPAB
gene id: 9031:HNRNPAB
uniprot id: Q90602
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:SPR
gene id: 9031:SPR
uniprot id: E1C4L3
names: Similarity
messages: Belongs to the sepiapterin reductase family.

9031:CSF2
gene id: 9031:CSF2
uniprot id: Q5W4T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

9031:LOC417937
gene id: 9031:LOC417937
uniprot id: E1BSS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

9031:GPSM1
gene id: 9031:GPSM1
uniprot id: A0A3Q2UCV7
uniprot id: E1BS79
names: Similarity
messages: Belongs to the GPSM family.

9031:MAPK1IP1L
gene id: 9031:MAPK1IP1L
uniprot id: A0A1D5NVN9
names: Similarity
messages: Belongs to the MISS family.

9031:SLC35F4
gene id: 9031:SLC35F4
uniprot id: F1NF95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9031:PCID2
gene id: 9031:PCID2
uniprot id: F1NEE3
names: Similarity
messages: Belongs to the CSN12 family.

9031:GPR65
gene id: 9031:GPR65
uniprot id: F1NJ83
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:YIPF5
gene id: 9031:YIPF5
uniprot id: E1C6B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9031:MYH1B
gene id: 9031:MYH1B
uniprot id: A0A1D5NVW6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:ADCYAP1
gene id: 9031:ADCYAP1
uniprot id: Q58FG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9031:GSDMA
gene id: 9031:GSDMA
uniprot id: A0A1L1RUM0
uniprot id: Q5ZHP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9031:TAC1
gene id: 9031:TAC1
uniprot id: F1NWH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9031:CLDN2
gene id: 9031:CLDN2
uniprot id: E1C8Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:RAMP3
gene id: 9031:RAMP3
uniprot id: B9VGZ4
names: Similarity
messages: Belongs to the RAMP family.

9031:UBA52
gene id: 9031:UBA52
uniprot id: O42388
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

9031:SRM
gene id: 9031:SRM
uniprot id: A0A1D5NY06
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

9031:PDE6C
gene id: 9031:PDE6C
uniprot id: P52731
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Cell membrane
messages: Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.

9031:SPEN
gene id: 9031:SPEN
uniprot id: A0A1D5P140
names: Similarity
messages: Belongs to the RRM Spen family.

9031:MERTK
gene id: 9031:MERTK
uniprot id: Q90777
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9031:MEOX2
gene id: 9031:MEOX2
uniprot id: Q90YH7
names: Subcellular Location Annotation
messages: Nucleus

9031:AK2
gene id: 9031:AK2
uniprot id: F1NJ73
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9031:CRPL1
gene id: 9031:CRPL1
uniprot id: Q2EJU6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9031:TMEM70
gene id: 9031:TMEM70
uniprot id: Q5ZLJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM70 family.
messages: Mitochondrion inner membrane
messages: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1. Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis.

9031:CYP3A5
gene id: 9031:CYP3A5
uniprot id: Q9PU44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:FAM13A
gene id: 9031:FAM13A
uniprot id: A0A1D5PTF6
names: Similarity
messages: Belongs to the FAM13 family.

9031:PPP2R5A
gene id: 9031:PPP2R5A
uniprot id: E1C5A3
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

9031:EIF3I
gene id: 9031:EIF3I
uniprot id: E1C6T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:PXN
gene id: 9031:PXN
uniprot id: P49024
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK.
messages: Interacts (via LD motif 4) with PARVA/PARVIN and ILK.
messages: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

9031:HDDC2
gene id: 9031:HDDC2
uniprot id: A0A1L1RPZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

9031:ENTPD8L2
gene id: 9031:ENTPD8L2
uniprot id: F1NJE7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9031:SEPSECS
gene id: 9031:SEPSECS
uniprot id: Q5F3Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9031:MRGPRH
gene id: 9031:MRGPRH
uniprot id: A0A3Q3ALN6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:SRPX2
gene id: 9031:SRPX2
uniprot id: A0A3Q2U607
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

9031:PGRMC1
gene id: 9031:PGRMC1
uniprot id: Q5ZKN2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). May be required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.
messages: Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.
messages: Microsome membrane
messages: Mitochondrion outer membrane
messages: Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
messages: Smooth endoplasmic reticulum membrane
messages: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 105 and 129.

9031:RPL35A
gene id: 9031:RPL35A
uniprot id: F1NQ35
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9031:FSHB
gene id: 9031:FSHB
uniprot id: Q8QGF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9031:JAG1
gene id: 9031:JAG1
uniprot id: E1BTW5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9031:AARS2
gene id: 9031:AARS2
uniprot id: Q5ZIA1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9031:NT5DC2
gene id: 9031:NT5DC2
uniprot id: A0A1D5PJ03
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9031:TSPAN18
gene id: 9031:TSPAN18
uniprot id: Q9PTE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:STK40
gene id: 9031:STK40
uniprot id: Q7T0B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9031:TPRA1
gene id: 9031:TPRA1
uniprot id: A0A1D5PME1
uniprot id: F1NB16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

9031:LCK
gene id: 9031:LCK
uniprot id: F1NP54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9031:RTN4
gene id: 9031:RTN4
uniprot id: A0A1D5P5K2
uniprot id: A0A1D5PD62
uniprot id: A0A1D5PPG9
uniprot id: A0A3Q2U086
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:CNBP
gene id: 9031:CNBP
uniprot id: O42395
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 40S ribosomal subunit, the 80S ribosome and with polysomes.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus
messages: Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity).

9031:LGR5
gene id: 9031:LGR5
uniprot id: E1C2F8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TSHB
gene id: 9031:TSHB
uniprot id: A5YW28
uniprot id: O57340
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Indispensable for the control of thyroid structure and metabolism.
messages: Secreted

9031:LIN7C
gene id: 9031:LIN7C
uniprot id: Q5F425
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules.
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains (By similarity). The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
messages: The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
messages: The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
messages: The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.

9031:SGPL1
gene id: 9031:SGPL1
uniprot id: A0A3Q3APG2
uniprot id: F1NMD8
uniprot id: Q5ZMK8
names: Similarity
messages: Belongs to the group II decarboxylase family.

9031:ZFYVE16
gene id: 9031:ZFYVE16
uniprot id: E1C1H1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9031:KIF18B
gene id: 9031:KIF18B
uniprot id: Q5ZLK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Cytoplasm
messages: May play an important role in microtubule plus-end depolymerizing activity in mitotic cells.
messages: Nucleus
messages: cytoskeleton

9031:GHITM
gene id: 9031:GHITM
uniprot id: A0A1D5PGF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9031:SLF2
gene id: 9031:SLF2
uniprot id: F1N9I2
names: Similarity
messages: Belongs to the FAM178 family.

9031:KCNA4
gene id: 9031:KCNA4
uniprot id: Q9YGX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

9031:TRMT44
gene id: 9031:TRMT44
uniprot id: E1C1E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
messages: Belongs to the TRM44 family.
messages: Cytoplasm

9031:FAM83C
gene id: 9031:FAM83C
uniprot id: A0A1D5PNL5
names: Similarity
messages: Belongs to the FAM83 family.

9031:ONECUT1
gene id: 9031:ONECUT1
uniprot id: A0A1D5NY75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9031:THRA
gene id: 9031:THRA
uniprot id: P04625
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus
messages: Probably interacts with SFPQ.

9031:TYSND1
gene id: 9031:TYSND1
uniprot id: A0A1D5P8S7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

9031:MMP13
gene id: 9031:MMP13
uniprot id: A0A7L8YSP2
uniprot id: O93363
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Secreted

9031:ARMC10
gene id: 9031:ARMC10
uniprot id: E1C223
names: Similarity
messages: Belongs to the eutherian X-chromosome-specific Armcx family.

9031:TRAPPC3
gene id: 9031:TRAPPC3
uniprot id: Q5ZI57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer. Part of the multisubunit TRAPP (transport protein particle) complex (By similarity).
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9031:ISCA1
gene id: 9031:ISCA1
uniprot id: Q5ZJ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
messages: Mitochondrion

9031:RHOT1
gene id: 9031:RHOT1
uniprot id: Q5ZM73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
messages: Mitochondrion outer membrane

9031:FHIP2A
gene id: 9031:FHIP2A
uniprot id: A0A1D5NZH5
uniprot id: A0A1D5P0U6
names: Similarity
messages: Belongs to the FHIP family.

9031:CLDN1
gene id: 9031:CLDN1
uniprot id: Q5ZMG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:VPS11
gene id: 9031:VPS11
uniprot id: A0A1D5PQT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

9031:HTR1E
gene id: 9031:HTR1E
uniprot id: E1BS44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SEPTIN2L
gene id: 9031:SEPTIN2L
uniprot id: Q5ZMH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity).
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Can form heterooligomers with other family members and form filaments (By similarity).
messages: cell cortex
messages: cilium membrane
messages: cytoskeleton
messages: spindle

9031:BARHL2
gene id: 9031:BARHL2
uniprot id: A0A1D5PW02
names: Subcellular Location Annotation
messages: Nucleus

9031:SF3B3
gene id: 9031:SF3B3
uniprot id: A0A1D6UPS9
names: Subcellular Location Annotation
messages: Nucleus

9031:WNT3A
gene id: 9031:WNT3A
uniprot id: A0A1D5PX88
uniprot id: Q2LMP1
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A palmitoylation site was proposed at Cys-77, but it was later shown that this cysteine is engaged in a disulfide bond.
messages: Belongs to the Wnt family.
messages: Cytoplasm
messages: Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine in WNT3A results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding (By similarity).
messages: Expressed in cornea. Isoform 1 is expressed in the primitive streak, dorsal neural tube, proximal otic vesicle, the apical ectodermal ridge and the epithelium of feather buds.
messages: In the eye, the expression was observed at stage 23 in the ocular surface epithelium ventral to the corneal epithelium. Strongly expressed in the entire ocular surface at stage 26 including the corneal epithelium. Remained strongly expressed at stage 30.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:17488271). Regulates chick apical ectodermal ridge formation (PubMed:17488271). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity).
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Not secreted.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors (PubMed:22046319). Depalmitoleoylation leads to inhibit the Wnt signaling pathway (By similarity).
messages: Secreted
messages: extracellular matrix

9031:PTGER4
gene id: 9031:PTGER4
uniprot id: A2TH16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

9031:CASC4
gene id: 9031:CASC4
uniprot id: A0A1D5PFD3
uniprot id: Q5ZKQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9031:TMED5
gene id: 9031:TMED5
uniprot id: Q5ZMT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9031:QARS
gene id: 9031:QARS
uniprot id: Q5F3C0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9031:GOSR1
gene id: 9031:GOSR1
uniprot id: Q5ZK51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9031:DGKZ
gene id: 9031:DGKZ
uniprot id: A0A3Q2U884
uniprot id: Q5F494
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9031:LOC426914
gene id: 9031:LOC426914
uniprot id: H9L3M8
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:ANXA2
gene id: 9031:ANXA2
uniprot id: A0A1C9KD18
uniprot id: P17785
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
messages: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.
messages: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
messages: Membrane
messages: basement membrane

9031:HGD
gene id: 9031:HGD
uniprot id: E1C3Y2
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9031:SIGIRR
gene id: 9031:SIGIRR
uniprot id: E1BR97
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9031:RPL30
gene id: 9031:RPL30
uniprot id: P67883
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL30 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9031:THBS2
gene id: 9031:THBS2
uniprot id: A0A3Q2UF62
uniprot id: P35440
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.
messages: Belongs to the thrombospondin family.
messages: Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:HOOK1
gene id: 9031:HOOK1
uniprot id: Q5ZJ27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hook family.
messages: Cytoplasm
messages: Interacts with microtubules.
messages: May function to promote vesicle trafficking and/or fusion.
messages: cytoskeleton

9031:BARX1
gene id: 9031:BARX1
uniprot id: Q9DED6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the BAR homeobox family.
messages: Expressed in smooth muscle cells of the upper digestive organs and their attached arteries and to craniofacial structures.
messages: Interacts with serum response factor (SRF).
messages: Nucleus
messages: Transcription factor which is involved with the serum response factor (SRF) in the smooth muscle cell-specific transcription of the beta-tropomyosin gene in the upper digestive organs and their attached arteries.

9031:NHSL2
gene id: 9031:NHSL2
uniprot id: R4GFL3
names: Similarity
messages: Belongs to the NHS family.

9031:KCNA3
gene id: 9031:KCNA3
uniprot id: Q7T195
names: Subcellular Location Annotation
messages: Membrane

9031:IGFBP5
gene id: 9031:IGFBP5
uniprot id: F1ND88
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:CWC15
gene id: 9031:CWC15
uniprot id: E1C8V6
names: Similarity
messages: Belongs to the CWC15 family.

9031:BRCC3
gene id: 9031:BRCC3
uniprot id: E1C8A6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9031:RNGTT
gene id: 9031:RNGTT
uniprot id: A0A3Q2UC80
uniprot id: E1C254
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9031:ENSA
gene id: 9031:ENSA
uniprot id: Q5ZIF8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A.
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).

9031:PGS1
gene id: 9031:PGS1
uniprot id: Q5ZHN9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by calcium and magnesium and inhibited by other bivalent cations.
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

9031:CHAC2
gene id: 9031:CHAC2
uniprot id: F1NE73
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9031:ELOVL1
gene id: 9031:ELOVL1
uniprot id: E3VVM5
uniprot id: Q5F345
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9031:SETD3
gene id: 9031:SETD3
uniprot id: Q5ZML9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin.
messages: The SET domain specifically recognizes and binds actin, suggesting that it does not accommodate substrates diverging from actin.

9031:BLOC1S5
gene id: 9031:BLOC1S5
uniprot id: Q5ZK77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking (By similarity).
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).

9031:MBLAC2
gene id: 9031:MBLAC2
uniprot id: Q5F336
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18.
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cell membrane
messages: Endoplasmic reticulum membrane

9031:SLC35E1
gene id: 9031:SLC35E1
uniprot id: F1NE93
names: Subcellular Location Annotation
messages: Membrane

9031:OASL
gene id: 9031:OASL
uniprot id: O13256
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

9031:DNAJA2
gene id: 9031:DNAJA2
uniprot id: Q5ZIZ7
names: Subcellular Location Annotation
messages: Membrane

9031:DPH1
gene id: 9031:DPH1
uniprot id: F1NBE0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

9031:HOXA1
gene id: 9031:HOXA1
uniprot id: R4GHI8
names: Subcellular Location Annotation
messages: Nucleus

9031:PHYHIPL
gene id: 9031:PHYHIPL
uniprot id: A0A1D5P7V0
names: Similarity
messages: Belongs to the PHYHIP family.

9031:P2RY8
gene id: 9031:P2RY8
uniprot id: Q5ZI82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Probable receptor for purines coupled to G-proteins.

9031:PRKCA
gene id: 9031:PRKCA
uniprot id: Q5F3X1
uniprot id: R4GHL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9031:MTFMT
gene id: 9031:MTFMT
uniprot id: A0A1D5NT29
names: Similarity
messages: Belongs to the Fmt family.

9031:DTX4
gene id: 9031:DTX4
uniprot id: F1NLX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9031:NKX2-3
gene id: 9031:NKX2-3
uniprot id: O73907
names: Subcellular Location Annotation
messages: Nucleus

9031:DERL3
gene id: 9031:DERL3
uniprot id: F6RIR9
uniprot id: Q5ZHP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9031:MAPK9
gene id: 9031:MAPK9
uniprot id: P79996
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
messages: Expressed in the neuroepithelium of developing brain at stages 16 to 26.
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

9031:KITLG
gene id: 9031:KITLG
uniprot id: Q009U4
uniprot id: Q009U6
uniprot id: Q09108
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form is produced by proteolytic processing of the extracellular domain.
messages: Acts in the early stages of hematopoiesis.
messages: Belongs to the SCF family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity).
messages: Secreted
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9031:FAM96A
gene id: 9031:FAM96A
uniprot id: Q5ZJP2
names: Similarity
messages: Belongs to the MIP18 family.

9031:LOC100859756
gene id: 9031:LOC100859756
uniprot id: A0A1D5PPB5
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:RSPO1
gene id: 9031:RSPO1
uniprot id: E1BVU3
names: Similarity
messages: Belongs to the R-spondin family.

9031:TMCO3
gene id: 9031:TMCO3
uniprot id: E1BT78
names: Subcellular Location Annotation
messages: Membrane

9031:RPS2
gene id: 9031:RPS2
uniprot id: E1C4M0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.

9031:LOC107055444
gene id: 9031:LOC107055444
uniprot id: A0A1D5P521
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Nucleus

9031:SGCG
gene id: 9031:SGCG
uniprot id: A0A1D5PL96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

9031:KCNV1
gene id: 9031:KCNV1
uniprot id: A0A1D5PA94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9031:HDAC7
gene id: 9031:HDAC7
uniprot id: Q5F432
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

9031:ASTL
gene id: 9031:ASTL
uniprot id: P0DJJ2
names: Cofactor
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cortical granule
messages: Cytoplasm
messages: Expressed in embryonic stem cells. Expressed in the pluripotent cells of the epiblast. Detected at the junction of non-neuronal and neuronal ectoderm just before neural tube closure. Expressed in the ventral epidermis before ventral closure, in the intermediate mesoderm, gonads and the forming nephric duct and tubules of the mesonephros and metanephros.
messages: Expressed in ovary and gonads.
messages: Probable oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. May act as a protease (By similarity).

9031:TMEM255A
gene id: 9031:TMEM255A
uniprot id: E1BZD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9031:TBR1
gene id: 9031:TBR1
uniprot id: A0A1D5P6N0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:DOHH
gene id: 9031:DOHH
uniprot id: Q5ZIP3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

9031:RPS26
gene id: 9031:RPS26
uniprot id: Q5ZM66
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

9031:PSD2
gene id: 9031:PSD2
uniprot id: A0A1D5P0H4
names: Subcellular Location Annotation
messages: ruffle membrane

9031:IPO13
gene id: 9031:IPO13
uniprot id: Q5ZIC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
messages: Nucleus

9031:CSNK2A1
gene id: 9031:CSNK2A1
uniprot id: P21868
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (By similarity). Plays an important role in the circadian clock function by phosphorylating BMAL1 (By similarity).
messages: Nucleus
messages: Tetramer composed of an alpha chain, an alpha' and two beta chains. Interacts with RNPS1 (By similarity).

9031:TFAP2B
gene id: 9031:TFAP2B
uniprot id: O93346
names: Similarity
messages: Belongs to the AP-2 family.

9031:NKIRAS1
gene id: 9031:NKIRAS1
uniprot id: E1BRD6
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9031:LGMN
gene id: 9031:LGMN
uniprot id: E1C958
names: Similarity
messages: Belongs to the peptidase C13 family.

9031:ADHFE1
gene id: 9031:ADHFE1
uniprot id: A0A1D5PNX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

9031:KBTBD8
gene id: 9031:KBTBD8
uniprot id: A0A1D5PX74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9031:FAM134B
gene id: 9031:FAM134B
uniprot id: A0A3Q2UE12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

9031:CHST1
gene id: 9031:CHST1
uniprot id: E1BV91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9031:DNAAF4
gene id: 9031:DNAAF4
uniprot id: Q5QIE2
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: neuron projection

9031:LAMC1
gene id: 9031:LAMC1
uniprot id: F1NI05
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9031:DLAT
gene id: 9031:DLAT
uniprot id: E1C6N5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

9031:SEMA6C
gene id: 9031:SEMA6C
uniprot id: A0A1L1RP59
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:NDUFB1
gene id: 9031:NDUFB1
uniprot id: A0A1D6UPT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:COMTD1
gene id: 9031:COMTD1
uniprot id: F1NI85
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9031:TNKS
gene id: 9031:TNKS
uniprot id: Q800D9
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:HMOX2
gene id: 9031:HMOX2
uniprot id: E1C7J0
names: Similarity
messages: Belongs to the heme oxygenase family.

9031:POLRMT
gene id: 9031:POLRMT
uniprot id: E1BZ13
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9031:RPL12
gene id: 9031:RPL12
uniprot id: E1BTG1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

9031:CPEB1
gene id: 9031:CPEB1
uniprot id: F1NY46
names: Similarity
messages: Belongs to the RRM CPEB family.

9031:SGK1
gene id: 9031:SGK1
uniprot id: A0A3Q2UHJ7
uniprot id: Q6U1I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus
messages: Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity).

9031:AvBD10
gene id: 9031:AvBD10
uniprot id: Q6QLQ9
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Detected in the theca and granulosa layers of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages.
messages: Expression in the theca and granulosa layers of the F3 stage ovarian follicle is not affected by intravenous injection of LPS.
messages: Has bactericidal activity.
messages: Secreted
messages: Strong expression in the testis, liver, gall bladder and kidney. Also expressed in the ovary and male and female reproductive tracts. Expressed in the ovarian stroma and the theca and granulosa layers of the ovarian follicle.

9031:PPT1
gene id: 9031:PPT1
uniprot id: Q5ZJT3
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9031:SMIM15
gene id: 9031:SMIM15
uniprot id: Q5F409
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9031:BORA
gene id: 9031:BORA
uniprot id: A0A3Q2U088
uniprot id: A0A3Q2UE79
uniprot id: Q5F3S1
names: Similarity
messages: Belongs to the BORA family.

9031:LMBR1L
gene id: 9031:LMBR1L
uniprot id: A0A1D5PDR6
names: Similarity
messages: Belongs to the LIMR family.

9031:UBE2V2
gene id: 9031:UBE2V2
uniprot id: Q5F3Z3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).
messages: Heterodimer with UBE2N.

9031:POLR3B
gene id: 9031:POLR3B
uniprot id: E1BRJ4
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9031:ART1L2
gene id: 9031:ART1L2
uniprot id: Q49L19
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:IREB2
gene id: 9031:IREB2
uniprot id: Q5ZLQ4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit. [4Fe-4S]-binding affects RNA-binding activity, thereby inhibiting activity of the protein.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
messages: Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen.

9031:IDH3B
gene id: 9031:IDH3B
uniprot id: Q5ZKN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9031:TMEM184C
gene id: 9031:TMEM184C
uniprot id: Q5ZMP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM184 family.
messages: May play a role in cell growth.
messages: Membrane

9031:RBL2
gene id: 9031:RBL2
uniprot id: F1NEZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9031:PRSS2
gene id: 9031:PRSS2
uniprot id: Q90629
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: High levels are seen in the pancreas while lower levels are found in the liver, spleen and thymus.
messages: extracellular space

9031:OVOA
gene id: 9031:OVOA
uniprot id: F1NZY2
uniprot id: Q98UI9
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Multimer; disulfide-linked.
messages: N-glycosylated. Complex glycosylation with bisecting N-acetylglucosamine. Contains mainly N-acetylglucosamine (3.1-8.5%), mannose (2.9-4.6%), a small amount of galactose (1.1-4.35) and sialic acid (0.3-1.3%). Most abundant glycan is composed of a GlcNAc(2)Man(3) core, a bisecting GlcNAc and another 3 GlcNAc antannae located on the mannoses of the core. Site Asn-1639 exists both in glycosylated and non-glycosylated forms.
messages: Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6.
messages: Secreted

9031:TMEM41A
gene id: 9031:TMEM41A
uniprot id: A0A1D5PJ35
uniprot id: F1P1Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9031:NPM2
gene id: 9031:NPM2
uniprot id: A0A3Q2U959
names: Similarity
messages: Belongs to the nucleoplasmin family.

9031:LOC100857512
gene id: 9031:LOC100857512
uniprot id: R4GFB4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:GRM2
gene id: 9031:GRM2
uniprot id: E1C8F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9031:MTUS1
gene id: 9031:MTUS1
uniprot id: A0A3Q2TYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTUS1 family.
messages: Nucleus

9031:LOC112529929
gene id: 9031:LOC112529929
uniprot id: A0A1D5PQ92
names: Similarity
messages: Belongs to the intermediate filament family.

9031:PPM1D
gene id: 9031:PPM1D
uniprot id: A0A1D5NXQ2
names: Similarity
messages: Belongs to the PP2C family.

9031:IGF2BP1
gene id: 9031:IGF2BP1
uniprot id: O42254
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM IMP/VICKZ family.
messages: Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Associates with the cytoskeleton, predominantly with actin filament bundles and occasionally with microtubules. In a heterologous system, interacts with ELAVL1, DHX9 and HNRNPU.
messages: Cytoplasm
messages: Domains KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute to transcript binding. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules. KH3 and KH4 mediate association with the cytoskeleton. Two nuclear export signals (NES) have been identified in KH2 and KH4 domains, respectively. Only KH2 NES is XPO1-dependent. Both NES may be redundant, since individual in vitro mutations do not affect subcellular location of the full length protein.
messages: Expressed in neurons and embryonic fibroblasts (at protein level).
messages: Nucleus
messages: P-body
messages: Phosphorylated by SRC at Tyr-396. This residue is involved in ACTB mRNA binding, its phosphorylation impairs association with ACTB mRNA and hence abolishes translational repression. Phosphorylation occurs in close proximity to filopodia and in the growth cones of differentiated neuroglioblastoma cells.
messages: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation in polarized cells, a crucial process for cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves by a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The ribonucleoparticle (RNP) thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, IGF2BP1 prevents beta-actin mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated by SRC. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. The monomeric ACTB protein then assembles into the subcortical actin cytoskeleton, which pushes the leading edge onwards. Binds MYC mRNA. Binding to MYC mRNA is enhanced by m6A-modification of the CRD (By similarity). Promotes the directed movement of cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphoryl…
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9031:NSUN6
gene id: 9031:NSUN6
uniprot id: E1BQJ7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9031:DENND5A
gene id: 9031:DENND5A
uniprot id: A0A1L1RT22
uniprot id: A0A3Q3ARC9
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:VRTN
gene id: 9031:VRTN
uniprot id: A0A1D5PDU0
names: Similarity
messages: Belongs to the vertnin family.

9031:CLDN14
gene id: 9031:CLDN14
uniprot id: E1C5Q7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:SUMO1
gene id: 9031:SUMO1
uniprot id: Q8QGH2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2 (By similarity). Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

9031:CTNNB1
gene id: 9031:CTNNB1
uniprot id: A0A1D5NYE8
uniprot id: A0A1D5PQN0
uniprot id: O42486
names: Similarity
messages: Belongs to the beta-catenin family.

9031:GNAQ
gene id: 9031:GNAQ
uniprot id: Q5F3B5
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9031:B3GAT2
gene id: 9031:B3GAT2
uniprot id: Q5CAS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:EXOC6
gene id: 9031:EXOC6
uniprot id: Q5ZJ05
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9031:CYP2AC7
gene id: 9031:CYP2AC7
uniprot id: A0A1L1RUT8
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:LEPR
gene id: 9031:LEPR
uniprot id: Q9I8V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9031:SERF2
gene id: 9031:SERF2
uniprot id: A0A3Q2ULA2
names: Similarity
messages: Belongs to the SERF family.

9031:INSRR
gene id: 9031:INSRR
uniprot id: H9KZZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9031:HMX1
gene id: 9031:HMX1
uniprot id: Q9DE09
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At stage 11, expressed in the surface ectoderm surrounding the optic vesicle. At stage 15, expressed in anterior/nasal side of the early retina. At stage 26, during the peak period of ganglion cell genesis, highly expressed in the nasal retina and the lens ectoderm.
messages: Belongs to the HMX homeobox family.
messages: DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear.
messages: Nucleus

9031:SMYD5
gene id: 9031:SMYD5
uniprot id: Q5ZIZ2
names: Function
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression.

9031:SNCA
gene id: 9031:SNCA
uniprot id: Q9I9H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse

9031:ZEB2
gene id: 9031:ZEB2
uniprot id: A0A0U4VU53
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9031:NPAS2
gene id: 9031:NPAS2
uniprot id: Q5ZQU2
names: Activity Regulation
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Carbon monoxide (CO) and the redox state of the cell can modulate the transcriptional activity of the NPAS2-BMAL1 heterodimer. NADH and NADPH enhance the DNA-binding activity of the heterodimer whereas CO binds the heme group in NPAS2 and inhibits the DNA-binding activity of the heterodimer.
messages: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with BMAL1 and this heterodimerization is required for E-box-dependent transactivation.
messages: Exhibits a circadian rhythm in the retina with peak levels in early subjective night. No circadian rhythm pattern in the pineal gland.
messages: Expressed in the retinal photoreceptor cells (at protein level). Expressed in the pineal gland and retina.
messages: Nucleus
messages: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a …

9031:POU2F1
gene id: 9031:POU2F1
uniprot id: A0A1D5PZY6
uniprot id: F1NSK6
uniprot id: P15143
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Interacts with NR3C1, AR and PGR.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity).

9031:TMEM59L
gene id: 9031:TMEM59L
uniprot id: F1P0P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:RNFT1
gene id: 9031:RNFT1
uniprot id: F1P4I2
names: Subcellular Location Annotation
messages: Membrane

9031:C9orf78
gene id: 9031:C9orf78
uniprot id: F1P4D4
names: Similarity
messages: Belongs to the TLS1 family.

9031:CBS
gene id: 9031:CBS
uniprot id: A0A3Q2UDX4
uniprot id: E1BYG4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

9031:BCAT1
gene id: 9031:BCAT1
uniprot id: A0A3Q2UDM7
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9031:USP35
gene id: 9031:USP35
uniprot id: A0A3Q2UDW5
names: Similarity
messages: Belongs to the peptidase C19 family.

9031:ADRA2C
gene id: 9031:ADRA2C
uniprot id: F1NDD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:RELL1
gene id: 9031:RELL1
uniprot id: Q5F3A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RELT family.
messages: Cell membrane

9031:RAN
gene id: 9031:RAN
uniprot id: P42558
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis.
messages: Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
messages: Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis. Interacts with KPNB1. Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity. Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP. Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP. Interacts (GTP-bound form) with TNPO1; the interaction is direct. Interacts (GTP-bound form) with TNPO3; the interaction is direct. Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity. Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity. Interacts with RANGRF, which promotes the release of bound guanine nucleotide. RANGRF and RCC1 compete for an overlapping binding site on RAN. Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex. Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1. Identified in a complex composed of RAN, RANGAP1 and RANBP1. Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a nuclear export complex with XPO1. Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1.
messages: Nucleus
messages: Nucleus envelope
messages: cytosol

9031:HAL
gene id: 9031:HAL
uniprot id: Q802A0
names: Similarity
messages: Belongs to the PAL/histidase family.

9031:DCTN6
gene id: 9031:DCTN6
uniprot id: F1NAP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

9031:GORAB
gene id: 9031:GORAB
uniprot id: F1NUY6
names: Similarity
messages: Belongs to the GORAB family.

9031:GANC
gene id: 9031:GANC
uniprot id: E1BTT7
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9031:MTMR6
gene id: 9031:MTMR6
uniprot id: A0A1L1S0G8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9031:JMJD1C
gene id: 9031:JMJD1C
uniprot id: F1N9P6
names: Subcellular Location Annotation
messages: Nucleus

9031:PODXL
gene id: 9031:PODXL
uniprot id: A0A3Q2UBE7
uniprot id: F1NXC1
uniprot id: O57604
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the podocalyxin family.
messages: Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes (By similarity). The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation.
messages: Cell membrane
messages: Expressed in thrombocytes, kidney podocytes, vascular endothelia and mono- and multipotent progenitors from the bone marrow (at protein level).
messages: Expressed on the surface of extra- and intraembryonic hematopoietic cells, neural tube, aorta, glomerulus, liver, heart and coelomic cavity in 4 day old embryo; in each of these tissues, detection is restricted to cells comprising the lumenal surfaces of tissues or boundary elements between tissues such as in the liver capsule, aorta, mesonephros, coelomic cavity and the central canal of the neural tube. Expressed in multipotent progenitors of day three yolk sac (at protein level).
messages: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells (By similarity). Induces the formation of apical actin-dependent microvilli.
messages: Membrane
messages: Membrane raft
messages: N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

9031:CAPZA3
gene id: 9031:CAPZA3
uniprot id: E1BUP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

9031:TMEM9
gene id: 9031:TMEM9
uniprot id: F1NKS2
names: Similarity
messages: Belongs to the TMEM9 family.

9031:SRD5A2
gene id: 9031:SRD5A2
uniprot id: F1NUW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane
messages: Microsome membrane

9031:TEX10
gene id: 9031:TEX10
uniprot id: Q5ZM41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of some MLL1/MLL complex. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.
messages: Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

9031:PHTF2
gene id: 9031:PHTF2
uniprot id: Q5ZKN3
names: Subcellular Location Annotation
messages: Membrane

9031:MYOZ2
gene id: 9031:MYOZ2
uniprot id: A0A1L1RJB3
names: Similarity
messages: Belongs to the myozenin family.

9031:SULT1B1
gene id: 9031:SULT1B1
uniprot id: Q8JG30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family.
messages: Cytoplasm
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3).

9031:SLC46A1
gene id: 9031:SLC46A1
uniprot id: F1NJ67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. SLC46A family.
messages: Cell membrane
messages: Cytoplasm
messages: Endosome membrane
messages: Monomer.
messages: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:34040256). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:34040256). Functions at acidic pH via alternate outward- and inward-open conformation states (PubMed:34040256). Protonation of residues in the outward open state primes the protein for transport (PubMed:34040256). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (PubMed:34040256). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:34040256). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity).
messages: Widely expressed, including brain, aorta, liver, kidney, spleen, small intestine, pancreas, ovary and testis.

9031:RECQL5
gene id: 9031:RECQL5
uniprot id: D3KR67
uniprot id: F1NWK5
uniprot id: Q8AYS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9031:TMEM63A
gene id: 9031:TMEM63A
uniprot id: F1P4T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9031:LONP1
gene id: 9031:LONP1
uniprot id: A0A1D5NYJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix

9031:PLK3
gene id: 9031:PLK3
uniprot id: A0A1D5P517
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9031:RSPO2
gene id: 9031:RSPO2
uniprot id: I0IVW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

9031:ERBB3
gene id: 9031:ERBB3
uniprot id: Q2HZD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9031:MRPS11
gene id: 9031:MRPS11
uniprot id: Q5ZL20
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9031:SFR1
gene id: 9031:SFR1
uniprot id: E1BXS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFR1/MEI5 family.
messages: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (By similarity). May act as a transcriptional modulator for ESR1 (By similarity).
messages: Component of the swi5-sfr1 complex.
messages: Nucleus

9031:STK4
gene id: 9031:STK4
uniprot id: Q5ZJK4
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Homodimer; mediated via the coiled-coil region.
messages: Nucleus
messages: Proteolytically cleaved by caspase-3 during apoptosis at Asp-325 resulting in a 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N) (By similarity).
messages: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
messages: The C-terminal non-catalytic region inhibits the kinase activity, the enzyme is activated by caspase-cleavage. Homodimerization and autophosphorylation of Thr-182 is also required for full activation (By similarity).

9031:MTCH2
gene id: 9031:MTCH2
uniprot id: Q9PVL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:STS
gene id: 9031:STS
uniprot id: A0A1D5PEM6
uniprot id: F1NGC8
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:MT3
gene id: 9031:MT3
uniprot id: A4PBT0
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9031:PLPPR3
gene id: 9031:PLPPR3
uniprot id: A0A1D5PYJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9031:VEGFRKDRL
gene id: 9031:VEGFRKDRL
uniprot id: F1NKN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane

9031:IGFBP3
gene id: 9031:IGFBP3
uniprot id: A6N8N6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:GABRG1
gene id: 9031:GABRG1
uniprot id: Q7LZ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:POLR2B
gene id: 9031:POLR2B
uniprot id: Q5ZMN9
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9031:TAL1
gene id: 9031:TAL1
uniprot id: P24899
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3 (By similarity).
messages: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation.
messages: Nucleus
messages: Phosphorylated on serine residues.

9031:RDX
gene id: 9031:RDX
uniprot id: Q9PU45
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
messages: cytoskeleton

9031:MEA1
gene id: 9031:MEA1
uniprot id: A0A1D5PZX0
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

9031:CDK9
gene id: 9031:CDK9
uniprot id: Q5ZKN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with cyclin-T to form P-TEFb. Also associates with cyclin-K (By similarity).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro (By similarity).
messages: Nucleus

9031:RRH
gene id: 9031:RRH
uniprot id: Q69FK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:UTS2B
gene id: 9031:UTS2B
uniprot id: Q6Q273
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

9031:PI15
gene id: 9031:PI15
uniprot id: Q98ST6
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: First expressed the mesoderm of the emerging dorsal pancreatic bud at stage 17-18. Also expressed in the thyroid anlagen. Expression persists throughout the dorsal pancreatic mesoderm through 6 dpc as the pancreas continues to enlarge. After 6 dpc, the amount of mesoderm in the pancreas declines to a minimal level and little or no expression is seen. The expression in the mesoderm of the thyroid persists at least through 8 dpc in the development of this organ. Weakly expressed within the emerging lung buds and developing gut. Also expressed in developing carniofacial structures. At stage 17, expression is restricted to the cranial paraxial mesoderm. At stage 24, expressed in the corners of the frontonasal mass (globular processes) where the lip will fuse. At stage 26 through 29, becomes focused in the center of the frontonasal mass. At stage 30, further restricted to the future egg tooth. By stage 34, found in the egg tooth and structures derived from the frontonasal mass, such as the premaxillary mesenchyme (PubMed:26385749).
messages: Secreted
messages: Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (PubMed:26385749).
messages: Up-regulated by Noggin/NOG and retinoic acid. May be a direct retinoic acid target.
messages: Was named SugarCrisp after the breakfast cereal.

9031:LUC7L
gene id: 9031:LUC7L
uniprot id: A0A3Q2UH51
names: Similarity
messages: Belongs to the Luc7 family.

9031:PRKRIP1
gene id: 9031:PRKRIP1
uniprot id: Q5ZKU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRKRIP1 family.
messages: Component of the pre-catalytic and post-catalytic spliceosome complexes.
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA (By similarity).
messages: nucleolus

9031:DPYS
gene id: 9031:DPYS
uniprot id: A0A1D5PMN7
uniprot id: A0A1L1RMS7
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9031:BDH1A
gene id: 9031:BDH1A
uniprot id: F1NHH9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:ARHGAP26
gene id: 9031:ARHGAP26
uniprot id: A0A1D5PAP4
uniprot id: Q5ZMW5
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds to the C-terminus of PTK2/FAK1.
messages: Detected in embryonic brain and liver, and at low levels in embryonic eye, heart, lung, intestine and skeletal muscle.
messages: GTPase-activating protein for RHOA and CDC42.
messages: cytoskeleton
messages: focal adhesion

9031:ING3
gene id: 9031:ING3
uniprot id: F1NI27
uniprot id: Q5ZK36
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).
messages: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9031:SP8
gene id: 9031:SP8
uniprot id: Q64HY5
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Detected in early stages of embryos as an oval and 2 stripes at HH stage 5, which becomes two lateral stripes at HH stage 7, running along the anteroposterior body axis from the head ectoderm to the anterior region of the primitive streak. At HH stage 8, strong expression in the anterior neuroectoderm, which forms the central nervous system, is observed, and at HH stage 9, expressed in the most anterior region of the forebrain, midbrain, neural groove and Hensen's node. At HH stage 15-16, the expression is seen in the surface ectoderm of the limb-forming fields, in addition to the neural tube. The expression in the limb field became confined to the distal region of the limb at HH stage 16 and 17, with still scattered signal visible in the surface ectoderm of the limb bud. Strongly expressed in the apical ectodermal ridge (AER) and weakly in the ectoderm in the developing limb bud at HH stage 21. The expression in the AER is detected throughout later stages of limb development.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.

9031:UBE2R2
gene id: 9031:UBE2R2
uniprot id: R4GIV8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:TAF5
gene id: 9031:TAF5
uniprot id: Q5F3I7
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9031:HSPB7
gene id: 9031:HSPB7
uniprot id: E1BV54
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

9031:RACK1
gene id: 9031:RACK1
uniprot id: E6N1V8
uniprot id: P63247
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity).
messages: Nucleus
messages: Perikaryon
messages: dendrite
messages: perinuclear region

9031:PPP2CA
gene id: 9031:PPP2CA
uniprot id: Q5ZM47
names: Similarity
messages: Belongs to the PPP phosphatase family.

9031:CHPT1
gene id: 9031:CHPT1
uniprot id: A0A1D5PJD6
uniprot id: A0A3Q2U5K3
uniprot id: Q5ZHQ5
uniprot id: R9PXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
messages: Golgi apparatus membrane

9031:MRAP2
gene id: 9031:MRAP2
uniprot id: A0A140B2F4
uniprot id: E1BS24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:RPF2
gene id: 9031:RPF2
uniprot id: A0A1D5PVA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

9031:FAM76B
gene id: 9031:FAM76B
uniprot id: F1NYM6
names: Similarity
messages: Belongs to the FAM76 family.

9031:LSM12
gene id: 9031:LSM12
uniprot id: Q5ZML5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LSM12 family.
messages: Cytoplasm
messages: Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein.

9031:CPB2
gene id: 9031:CPB2
uniprot id: F1NXB6
names: Similarity
messages: Belongs to the peptidase M14 family.

9031:BZW2
gene id: 9031:BZW2
uniprot id: F1NM03
uniprot id: Q5ZL42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BZW family.
messages: Cytoplasm
messages: Translation initiation regulator which may repress non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function.

9031:TP53I3
gene id: 9031:TP53I3
uniprot id: E1C9A2
names: Similarity
messages: Belongs to the profilin family.

9031:ELAVL2
gene id: 9031:ELAVL2
uniprot id: A0A3Q2UCB0
uniprot id: R4GFW0
names: Similarity
messages: Belongs to the RRM elav family.

9031:PIK3CA
gene id: 9031:PIK3CA
uniprot id: O42391
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9031:CYP46A1
gene id: 9031:CYP46A1
uniprot id: F1NEB6
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:XPOT
gene id: 9031:XPOT
uniprot id: E1C593
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9031:SELENOW
gene id: 9031:SELENOW
uniprot id: D0EYG3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SelWTH family. Selenoprotein W subfamily.
messages: Cytoplasm
messages: Expressed ubiquitously with predominant expression in the pituitary, spinal cord, sciatic nerve, cerebral cortex, cerebral nuclei, thalamus, cerebellum, muscle, cartilage, trachea, gizzard and artery. Weakly expressed in pancreas, testis, ovary, kidney and veins.
messages: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).
messages: Up-regulated by dietary selenium in cerebral tissue.

9031:CACNG1
gene id: 9031:CACNG1
uniprot id: F1NC88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

9031:RPS23
gene id: 9031:RPS23
uniprot id: F1NDC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

9031:CYP26B1
gene id: 9031:CYP26B1
uniprot id: F1NZL3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:EHD3
gene id: 9031:EHD3
uniprot id: Q5ZM17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

9031:UNC45A
gene id: 9031:UNC45A
uniprot id: A0A1D5P9T4
names: Subcellular Location Annotation
messages: perinuclear region

9031:EMC3
gene id: 9031:EMC3
uniprot id: E1BQV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

9031:KCNB1
gene id: 9031:KCNB1
uniprot id: E1BYX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: sarcolemma
messages: synaptosome

9031:PPM1K
gene id: 9031:PPM1K
uniprot id: F1P138
names: Similarity
messages: Belongs to the PP2C family.

9031:ISOC1
gene id: 9031:ISOC1
uniprot id: F1NS88
names: Similarity
messages: Belongs to the isochorismatase family.

9031:P2RX5
gene id: 9031:P2RX5
uniprot id: Q9IAD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9031:PKIA
gene id: 9031:PKIA
uniprot id: Q90641
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9031:LLPH
gene id: 9031:LLPH
uniprot id: Q5ZHK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the learning-associated protein family.
messages: Chromosome
messages: Regulates dendritic and spine growth and synaptic transmission.
messages: nucleolus

9031:SOBP
gene id: 9031:SOBP
uniprot id: A7XYH5
names: Function
names: Similarity
messages: Belongs to the SOBP family.
messages: Implicated in development of the cochlea.

9031:TRH
gene id: 9031:TRH
uniprot id: Q6ZXC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

9031:LSM8
gene id: 9031:LSM8
uniprot id: E1BZ75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

9031:FRRS1
gene id: 9031:FRRS1
uniprot id: E1C859
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9031:AGO3
gene id: 9031:AGO3
uniprot id: F1P3Z0
uniprot id: Q5ZLG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Ago subfamily.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.

9031:BF1
gene id: 9031:BF1
uniprot id: A0A1D5PBG2
uniprot id: A0ZXL5
uniprot id: Q5PY04
names: Similarity
messages: Belongs to the MHC class I family.

9031:GRIN2C
gene id: 9031:GRIN2C
uniprot id: R4GFN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

9031:HSPA5
gene id: 9031:HSPA5
uniprot id: Q90593
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cell surface
messages: Cytoplasm
messages: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). May also play a role in apoptosis and cell proliferation (By similarity).
messages: Endoplasmic reticulum lumen
messages: Melanosome
messages: Monomer and homooligomer; homooligomerization via the interdomain linker inactivates the chaperone activity and acts as a storage of HSPA5/BiP molecules (By similarity). Interacts with DNAJC10 (By similarity). Interacts with DNAJB9/ERdj4; leading to recruit HSPA5/BiP to ERN1/IRE1. Interacts with ERN1/IRE1; interaction takes place following interaction with DNAJB9/ERdj4 and leads to inactivate ERN1/IRE1 (By similarity).
messages: The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains (By similarity). In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction (By similarity). In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates (By similarity). J domain-containing co-chaperones (DNAJB9/ERdj4 or DNAJC10/ERdj5) stimulate the ATPase activity and are required for efficient substrate recognition by HSPA5/BiP. Homooligomerization inactivates participating HSPA5/BiP protomers and probably act as reservoirs to store HSPA5/BiP molecules when they are not needed by the cell (By similarity).
messages: The interdomain linker regulates the chaperone activity by mediating the formation of homooligomers. Homooligomers are formed by engagement of the interdomain linker of one HSPA5/BiP molecule as a typical substrate of an adjacent HSPA5/BiP molecule. HSPA5/BiP oligomerization inactivates participating HSPA5/BiP protomers. HSPA5/BiP oligomers probably act as reservoirs to store HSPA5/BiP molecules when they are not needed by the cell. When the levels of unfolded proteins rise, cells can rapidly break up these oligomers to make active monomers.

9031:SLC2A11L5
gene id: 9031:SLC2A11L5
uniprot id: A0A3Q2UNR7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:BCL2
gene id: 9031:BCL2
uniprot id: Q00709
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Also interacts with APAF1 and RAF-1 (By similarity).
messages: In adult chicken expressed, in thymus, spleen, kidney, heart, ovary and brain, with the highest levels in the thymus. In the embryo, highly levels expressed in all tissues with high levels in the bursa of Fabricius.
messages: Mitochondrion outer membrane
messages: Nucleus membrane
messages: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
messages: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1.

9031:HSD11B1L
gene id: 9031:HSD11B1L
uniprot id: Q6PUF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Secreted

9031:ST6GAL2
gene id: 9031:ST6GAL2
uniprot id: E1BZW3
uniprot id: Q701R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.

9031:PROS1
gene id: 9031:PROS1
uniprot id: A0A3Q2U504
names: Caution
names: Function
messages: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PARP6
gene id: 9031:PARP6
uniprot id: A0A3Q3APE1
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:SLC25A36
gene id: 9031:SLC25A36
uniprot id: Q5ZKP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism.
messages: Mitochondrion inner membrane

9031:BHMT2
gene id: 9031:BHMT2
uniprot id: E1BSH9
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9031:KCNJ2
gene id: 9031:KCNJ2
uniprot id: P52186
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Found in the apical basilar papilla of the inner ear, brain, muscle, cerebellum, heart and liver.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3, resulting in an enhanced G-protein-induced current. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).
messages: Membrane
messages: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

9031:CEP57L1
gene id: 9031:CEP57L1
uniprot id: E1C0V0
names: Similarity
messages: Belongs to the translokin family.

9031:FRZB
gene id: 9031:FRZB
uniprot id: Q9IA95
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At stage 7 of embryonic development, expressed in the neural plate with lower expression in the midline. At stage 9, expression restricted to the dorsal neural tube and cranial neural crest. At stage 12, expressed in the lateral plate mesoderm. In the developing trunk, expressed, from stages 9-12, in the ventral migrating neural crest with some expression at stage 12 in the dorsal streams From stage 15, expressed in the endocardial cells of the outflow tract of the developing heart. From stage 18, expression found in the epibranchial placodes, in endocardial and mesenchymal cells of the developing atrioventricular canal and of the outflow tract cushions. Expression in these regions of the developing heart continue until stage 26. During limb development, low expression found, by stage 18, in the developing limb buds, By stage 20, highly expressed in the ventral mesenchyme of both fore- and hind-limb buds. By stage 24, expression localized to the central core of the developing limb bud, which contains the chondrogenic precursors. Also expressed in the surrounding nonchondrogenic mesenchyme. Later expression confined to the perichondrium and to the epiphyses of the early developing skeletal elements.
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
messages: The FZ domain is involved in binding with Wnt ligands.

9031:EIF2S2
gene id: 9031:EIF2S2
uniprot id: Q9DEQ6
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9031:HPGD
gene id: 9031:HPGD
uniprot id: E1C688
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:MYO1A
gene id: 9031:MYO1A
uniprot id: A0A1D5PQB7
uniprot id: P47807
names: Caution
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Could play an important role in morphogenesis and function of intestinal microvilli.
messages: Intestine.
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).

9031:COX16
gene id: 9031:COX16
uniprot id: E1C6R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

9031:MYH1E
gene id: 9031:MYH1E
uniprot id: P13538
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: myofibril

9031:WDR91
gene id: 9031:WDR91
uniprot id: Q5ZLL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.
messages: Late endosome membrane

9031:CAPRIN1
gene id: 9031:CAPRIN1
uniprot id: Q5XNV3
names: Similarity
messages: Belongs to the caprin family.

9031:SPARCL1
gene id: 9031:SPARCL1
uniprot id: A0A1L1RTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9031:ATP8B1
gene id: 9031:ATP8B1
uniprot id: A0A1D5PRN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:RPIA
gene id: 9031:RPIA
uniprot id: Q5ZI35
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

9031:PRRX2
gene id: 9031:PRRX2
uniprot id: R4GIL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9031:LOC395100
gene id: 9031:LOC395100
uniprot id: Q2TV23
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

9031:NT5C3B
gene id: 9031:NT5C3B
uniprot id: Q5ZKF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm
messages: Monomer.
messages: Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity).

9031:NAP1L1
gene id: 9031:NAP1L1
uniprot id: E1BZS2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9031:TMC3
gene id: 9031:TMC3
uniprot id: Q5YCC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TMC family.
messages: Expressed in a range of tissues including cerebrum, cerebellum, retina, cochlea, lung, liver and heart. Also expressed in the apical, medial and basal portions of the basillar papilla.
messages: Membrane
messages: Probable ion channel.

9031:CRYGS
gene id: 9031:CRYGS
uniprot id: D0UYB8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9031:ZPBP1
gene id: 9031:ZPBP1
uniprot id: F1NQ00
uniprot id: Q5F3P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

9031:EPHA5
gene id: 9031:EPHA5
uniprot id: F1NSE6
names: Subcellular Location Annotation
messages: Membrane

9031:FERMT1
gene id: 9031:FERMT1
uniprot id: F1NPF7
names: Similarity
messages: Belongs to the kindlin family.

9031:OR52B2L
gene id: 9031:OR52B2L
uniprot id: E1C4Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:NT5DC1
gene id: 9031:NT5DC1
uniprot id: E1C3Z6
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

9031:CAB39
gene id: 9031:CAB39
uniprot id: R4GI86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9031:NFASC
gene id: 9031:NFASC
uniprot id: A0A1D5NY88
uniprot id: A0A1D5NYU8
uniprot id: A0A1D5P601
uniprot id: A0A1D5PN99
uniprot id: A0A3Q2U092
uniprot id: O42414
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
messages: Cell membrane
messages: May be proteolytically cleaved at Arg-636.
messages: Membrane
messages: N-glycosylated and O-glycosylated.
messages: There is one major 'early' isoform and multiple 'late' isoforms. Around 50 isoforms are found at different developmental stages.

9031:SPATS2L
gene id: 9031:SPATS2L
uniprot id: A0A3S5ZPL8
uniprot id: Q5ZHU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

9031:KPNA6
gene id: 9031:KPNA6
uniprot id: F7B5S0
uniprot id: Q5ZJZ0
names: Similarity
messages: Belongs to the importin alpha family.

9031:C17orf58
gene id: 9031:C17orf58
uniprot id: E1BZB3
names: Subcellular Location Annotation
messages: Secreted

9031:PTPRN
gene id: 9031:PTPRN
uniprot id: A0A1D5PAA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9031:GRAMD1C
gene id: 9031:GRAMD1C
uniprot id: A0A1D5PFV8
uniprot id: A0A1D5PM04
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:SYK
gene id: 9031:SYK
uniprot id: F1N9Y5
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region) to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation. The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement. Downstream signaling adapters and intermediates may mediate positive and/or negative feedback regulation (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
messages: Cell membrane
messages: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors.
messages: The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins.
messages: cytosol

9031:SEC31B
gene id: 9031:SEC31B
uniprot id: A0A3Q2TX69
uniprot id: A0A3Q2TZ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

9031:KPNA1
gene id: 9031:KPNA1
uniprot id: Q5ZML1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin alpha family.
messages: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
messages: Cytoplasm
messages: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
messages: Nucleus
messages: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
messages: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).

9031:PFN2
gene id: 9031:PFN2
uniprot id: Q5ZL50
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

9031:PPP1RL
gene id: 9031:PPP1RL
uniprot id: O13155
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

9031:SPINK2
gene id: 9031:SPINK2
uniprot id: A0A3Q2U1E0
names: Subcellular Location Annotation
messages: Secreted

9031:TM4SF1
gene id: 9031:TM4SF1
uniprot id: A0A1D5NY90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9031:ANKRD52
gene id: 9031:ANKRD52
uniprot id: Q5ZLC8
names: Function
names: Subunit
messages: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS).
messages: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

9031:NDUFS5
gene id: 9031:NDUFS5
uniprot id: E1C5D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9031:CHRNB4
gene id: 9031:CHRNB4
uniprot id: Q7T3Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:SLCO2B1
gene id: 9031:SLCO2B1
uniprot id: E1C5S3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:HLF
gene id: 9031:HLF
uniprot id: F1NBU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9031:FOPNL
gene id: 9031:FOPNL
uniprot id: Q5ZJ24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEP43 family.
messages: Cytoplasmic granule
messages: Homooligomer; probably required for localization to centrosomes.
messages: Involved in the biogenesis of cilia (By similarity). Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity).
messages: centriolar satellite
messages: centrosome
messages: cilium
messages: cilium basal body

9031:MANBAL
gene id: 9031:MANBAL
uniprot id: A0A1D5NZB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9031:DENND11
gene id: 9031:DENND11
uniprot id: F1P1J3
names: Similarity
messages: Belongs to the DENND11 family.

9031:EMC8
gene id: 9031:EMC8
uniprot id: F1N8E6
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9031:ASIC1
gene id: 9031:ASIC1
uniprot id: A0A3Q2UFS5
uniprot id: Q1XA76
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.
messages: Cell membrane
messages: Channel opening involves a conformation change that affects primarily the extracellular domain and the second transmembrane helix and its orientation in the membrane. In the open state, the second transmembrane helix is nearly perpendicular to the plane of the membrane; in the desensitized state it is strongly tilted. Besides, the second transmembrane domain is discontinuously helical in the open state. The GAS motif of the selectivity filter is in an extended conformation, giving rise to a distinct kink in the polypeptide chain. A domain swap between subunits gives rise to a full-length transmembrane helix.
messages: Homotrimer. Interacts with spider venom psalmotoxin 1 with a one to one stoichiometry. Interacts with the heterodimeric snake venom neurotoxin composed of MitTx-alpha and MitTx-beta.
messages: Inhibited by the diuretic amiloride. Inhibited by Cs(1+) ions. Inhibited by the spider venom psalmotoxin-1; this locks the channel into its desensitized conformation. Channel activity is increased by the heterodimeric snake venom neurotoxin composed of MitTx-alpha and MitTx-beta; this slows channel closure and increases the magnitude of the steady-state current that is triggered by low pH.
messages: Membrane
messages: Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.

9031:FAM65A
gene id: 9031:FAM65A
uniprot id: A0A1D5NVC5
uniprot id: A0A3Q2U2G0
uniprot id: A0A3Q3AG36
names: Similarity
messages: Belongs to the RIPOR family.

9031:NRXN1
gene id: 9031:NRXN1
uniprot id: A0A1D5PHD8
uniprot id: D0PRN2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neurexin family.
messages: Brain and arteries (at protein level).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling (By similarity). Plays a role in angiogenesis.

9031:CNKSR2
gene id: 9031:CNKSR2
uniprot id: A0A3Q2U909
uniprot id: F1NN17
names: Similarity
messages: Belongs to the CNKSR family.

9031:RFLNA
gene id: 9031:RFLNA
uniprot id: E1BR21
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9031:UNC93A
gene id: 9031:UNC93A
uniprot id: F1NVP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9031:FTSJ3
gene id: 9031:FTSJ3
uniprot id: A0A1D5PNW7
uniprot id: Q5ZKM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

9031:FOSL2
gene id: 9031:FOSL2
uniprot id: P18625
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Fos subfamily.
messages: Heterodimer with JUN.
messages: Nucleus
messages: Serum inducible, and cycloheximide superinducible.

9031:ACTR3B
gene id: 9031:ACTR3B
uniprot id: F1NW48
names: Similarity
messages: Belongs to the actin family.

9031:BAZ2B
gene id: 9031:BAZ2B
uniprot id: A0A1D5NTV5
uniprot id: A0A1D5PQ94
uniprot id: Q9DE13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WAL family.
messages: Nucleus
messages: Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (By similarity). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (By similarity). Chromatin reader protein (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by transcriptional regulation (By similarity).

9031:MMS19
gene id: 9031:MMS19
uniprot id: F1NS60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

9031:LOC121106455
gene id: 9031:LOC121106455
uniprot id: E1BZ23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9031:PEPD
gene id: 9031:PEPD
uniprot id: Q5ZKL3
names: Similarity
messages: Belongs to the peptidase M24B family.

9031:TNC
gene id: 9031:TNC
uniprot id: A0A1D5PJ88
uniprot id: A0A3Q2U5M0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:CDCA7L
gene id: 9031:CDCA7L
uniprot id: A0A1D5PAZ0
uniprot id: Q5F343
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:GLB1L
gene id: 9031:GLB1L
uniprot id: F1NW93
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9031:SIRT3
gene id: 9031:SIRT3
uniprot id: A0A1D5NYI2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

9031:GHRHR
gene id: 9031:GHRHR
uniprot id: Q1PCF1
uniprot id: Q309X7
names: Subcellular Location Annotation
messages: Membrane

9031:CEP57
gene id: 9031:CEP57
uniprot id: F1NYM7
names: Similarity
messages: Belongs to the translokin family.

9031:SLC25A39
gene id: 9031:SLC25A39
uniprot id: A0A1D5NTM6
uniprot id: A0A1D5PY28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:HCN1
gene id: 9031:HCN1
uniprot id: F1N9K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9031:SATB2
gene id: 9031:SATB2
uniprot id: E1ANH5
uniprot id: E1BZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9031:IDUA
gene id: 9031:IDUA
uniprot id: Q5F366
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

9031:RPS28
gene id: 9031:RPS28
uniprot id: A0A3Q2U825
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

9031:PPIL2
gene id: 9031:PPIL2
uniprot id: A0A3Q2U2B8
uniprot id: Q5ZJH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

9031:ORM1
gene id: 9031:ORM1
uniprot id: Q8JIG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Functions as transport protein in the blood stream.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9031:ABCC3
gene id: 9031:ABCC3
uniprot id: F1NM51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9031:SULT4A1
gene id: 9031:SULT4A1
uniprot id: E1C8B2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:ATG4C
gene id: 9031:ATG4C
uniprot id: A0A1D5PHI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9031:LOC426957
gene id: 9031:LOC426957
uniprot id: A0A3Q3B2H5
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:ST7L
gene id: 9031:ST7L
uniprot id: A0A452J7Y8
uniprot id: Q90YH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9031:ABHD13
gene id: 9031:ABHD13
uniprot id: Q5ZJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Membrane

9031:IL16
gene id: 9031:IL16
uniprot id: Q70XC4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

9031:IL2RA
gene id: 9031:IL2RA
uniprot id: Q90WJ4
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9031:CCNB1
gene id: 9031:CCNB1
uniprot id: A0A1D5PKB6
uniprot id: P29332
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
messages: Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

9031:CAND1
gene id: 9031:CAND1
uniprot id: F1NHL2
names: Similarity
messages: Belongs to the CAND family.

9031:NFKB2
gene id: 9031:NFKB2
uniprot id: P98150
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of the NF-kappa-B RelB-p52 complex.
messages: Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which contains the death domain.
messages: Cytoplasm
messages: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the en…
messages: NF-kappa-B p100 is one of the high-molecular-weight proteins complexed with the v-rel oncoprotein in transformed chicken spleen cells.
messages: Nucleus
messages: The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation.
messages: The glycine-rich region (GRR) appears to be a critical element in the generation of p52.
messages: While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing (By similarity).

9031:GUSB
gene id: 9031:GUSB
uniprot id: A0A1L1RSD2
uniprot id: Q5ZIA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Lysosome

9031:LAMP2
gene id: 9031:LAMP2
uniprot id: A0A3Q2U0K1
uniprot id: A0A452J7X9
uniprot id: Q90617
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMP family.
messages: Cell membrane
messages: Endosome membrane
messages: Extensively N-glycosylated. Contains a minor proportion of O-linked glycans.
messages: Lysosome membrane
messages: Monomer. Forms large homooligomers. Interacts (via its cytoplasmic region) with HSPA8. Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity).
messages: Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (By similarity). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes. Required for normal degradation of the contents of autophagosomes. Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits. Is not required for efficient MHCII-mediated presentation of endogenous antigens (By similarity).
messages: autophagosome membrane

9031:LOC428295
gene id: 9031:LOC428295
uniprot id: A0A1D5PBX6
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:APC2
gene id: 9031:APC2
uniprot id: D2W6W9
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

9031:SLC26A4
gene id: 9031:SLC26A4
uniprot id: E1C3I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

9031:ASAH1
gene id: 9031:ASAH1
uniprot id: Q5ZK58
names: Similarity
messages: Belongs to the acid ceramidase family.

9031:DLK1
gene id: 9031:DLK1
uniprot id: B7SFV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:INHBE
gene id: 9031:INHBE
uniprot id: A0A3Q2TUG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9031:PON1
gene id: 9031:PON1
uniprot id: F1NCU9
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

9031:UTRN
gene id: 9031:UTRN
uniprot id: A0A1D5P9A8
uniprot id: F1NI75
names: Function
names: Subcellular Location Annotation
messages: May play a role in anchoring the cytoskeleton to the plasma membrane.
messages: cytoskeleton

9031:PAN2
gene id: 9031:PAN2
uniprot id: Q5F450
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9031:LOC396480
gene id: 9031:LOC396480
uniprot id: H9KZL7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:SPIA3
gene id: 9031:SPIA3
uniprot id: F1NPN5
names: Similarity
messages: Belongs to the serpin family.

9031:MRPL51
gene id: 9031:MRPL51
uniprot id: Q5ZKG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).
messages: Mitochondrion

9031:EVL
gene id: 9031:EVL
uniprot id: Q5ZIC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: lamellipodium
messages: stress fiber

9031:STMN2
gene id: 9031:STMN2
uniprot id: Q90987
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Expression is neuron-specific and found in cerebellum, forebrain, midbrain, tectum and spinal cord.
messages: Is a key regulator of neurite extension through regulation of microtubule instabilily.
messages: Membrane
messages: axon
messages: growth cone
messages: lamellipodium
messages: perinuclear region

9031:IFT43
gene id: 9031:IFT43
uniprot id: A0A1D5PGF9
uniprot id: F1NJS3
names: Similarity
messages: Belongs to the IFT43 family.

9031:RFTN2
gene id: 9031:RFTN2
uniprot id: A0A1D5PGW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9031:INVS
gene id: 9031:INVS
uniprot id: Q8UVC3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds calmodulin via its IQ domains. Interacts with APC2 (By similarity).
messages: Cytoplasm
messages: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity).
messages: The D-box (destruction box) mediate the interaction with APC proteins, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: cytoskeleton

9031:FAM173A
gene id: 9031:FAM173A
uniprot id: A0A1D5P7I3
uniprot id: A0A1D5PG38
uniprot id: E1BSP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9031:CYP2AC2
gene id: 9031:CYP2AC2
uniprot id: A0A1L1RWI4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:NDFIP1
gene id: 9031:NDFIP1
uniprot id: A0A1D5PYN1
names: Subcellular Location Annotation
messages: Membrane

9031:AMY2A
gene id: 9031:AMY2A
uniprot id: A0A1D5PUZ5
uniprot id: Q98942
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9031:MAFA
gene id: 9031:MAFA
uniprot id: O42290
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. Maf subfamily.
messages: First detected in the lens placode at stage 11, when the head ectoderm makes contact with the optic vesicle. The expression remains restricted to the invaginating lens placode, and subsequently to the developing lens vesicle. In 8-day old embryo, almost exclusively expressed in lens with very weak expression in brain.
messages: Forms homodimers or heterodimers. May interact (via leucine-zipper domain) with MAFB. May interact with FOS and JUN. Interacts with PCAF; this interaction impairs MAFA ubiquitination.
messages: Nucleus
messages: Transcription factor involved in transcription regulation during lens development, including that of crystallin and filensin/BFSP1 genes (PubMed:9525857). Binds to CRE-type MARE 5'-TGCTGACGTCAGCA-3' and TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequences (PubMed:12970735).

9031:ACSM5
gene id: 9031:ACSM5
uniprot id: A0A1D5PJF2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9031:GPT2
gene id: 9031:GPT2
uniprot id: A0A1D5PND8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9031:PPP1CB
gene id: 9031:PPP1CB
uniprot id: P62207
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Detected in gizzard (at protein level).
messages: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress (By similarity).
messages: Nucleus
messages: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen (By similarity).
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.

9031:UBE2A
gene id: 9031:UBE2A
uniprot id: Q9W6F3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:RNF166
gene id: 9031:RNF166
uniprot id: Q5F3B2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates.

9031:SLC6A7
gene id: 9031:SLC6A7
uniprot id: F1NG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:IMPA1
gene id: 9031:IMPA1
uniprot id: A0A1D5PHE2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9031:COX17
gene id: 9031:COX17
uniprot id: F1NPL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

9031:FAM3C
gene id: 9031:FAM3C
uniprot id: E1BWA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9031:SYBU
gene id: 9031:SYBU
uniprot id: A0A1D5NVV7
names: Subcellular Location Annotation
messages: Membrane

9031:SPINK4
gene id: 9031:SPINK4
uniprot id: A0A1L1RML9
names: Subcellular Location Annotation
messages: Secreted

9031:HTATSF1
gene id: 9031:HTATSF1
uniprot id: F1P1G7
names: Similarity
messages: Belongs to the HTATSF1 family.

9031:PARP3
gene id: 9031:PARP3
uniprot id: E1BSI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:27530147). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 (By similarity). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA (PubMed:27530147). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (By similarity). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity).
messages: Nucleus
messages: centriole
messages: centrosome

9031:TGIF2
gene id: 9031:TGIF2
uniprot id: A0A1D5P8I9
names: Subcellular Location Annotation
messages: Nucleus

9031:TAF2
gene id: 9031:TAF2
uniprot id: Q5ZIT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF2 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs).
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs).

9031:PIWIL1
gene id: 9031:PIWIL1
uniprot id: A6N7Y9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Piwi subfamily.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs (By similarity).
messages: Methylated on arginine residues; required for the interaction with Tudor domain-containing protein and subsequent localization to the meiotic nuage, also named P granule.
messages: The PAZ domain specifically recognizes binds the 2'-O-methylated 3'-end of piRNAs. The MID region is required for recognition of uridine in the first position of piRNAs (g1U preference, also named 1U-bias).

9031:NDUFA5
gene id: 9031:NDUFA5
uniprot id: E1BRT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9031:DTX3L
gene id: 9031:DTX3L
uniprot id: F1NFB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9031:CDK5RAP3
gene id: 9031:CDK5RAP3
uniprot id: Q5F3L8
names: Similarity
messages: Belongs to the CDK5RAP3 family.

9031:CDC25A
gene id: 9031:CDC25A
uniprot id: A0A1D5PY31
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

9031:HAGHL
gene id: 9031:HAGHL
uniprot id: Q5ZLY2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Hydrolase acting on ester bonds.

9031:ARSA
gene id: 9031:ARSA
uniprot id: A0A1D5PS44
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:KAT2A
gene id: 9031:KAT2A
uniprot id: F1NSS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

9031:EIF3M
gene id: 9031:EIF3M
uniprot id: Q5ZJ64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:PSMD2
gene id: 9031:PSMD2
uniprot id: Q5ZLU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

9031:UCP3
gene id: 9031:UCP3
uniprot id: Q9DDT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9031:KIF26B
gene id: 9031:KIF26B
uniprot id: E1C4G2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:INIP
gene id: 9031:INIP
uniprot id: F1NAD7
uniprot id: Q5ZJ32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Belongs to the multiprotein complex Integrator. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP (By similarity).
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity).
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9031:KCNMB1
gene id: 9031:KCNMB1
uniprot id: O93393
names: Subcellular Location Annotation
messages: Membrane

9031:RECK
gene id: 9031:RECK
uniprot id: A0A1D5PUP4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RECK family.
messages: Cell membrane
messages: Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (By similarity). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. Also acts as a serine protease inhibitor (By similarity).
messages: Interacts (via knot repeats) with WNT7A (via disordered linker region); the interaction is direct (By similarity). Interacts (via knot repeats) with WNT7B (via disordered linker region); the interaction is direct (By similarity). Interacts with ADGRA2; the interaction is direct (By similarity).
messages: Localizes to the plasma membrane via its GPI-anchor (PubMed:23329048). Released from the plasma membrane following cleavage of the GPI-anchor by GDPD5/GPE2 (PubMed:23329048).
messages: The Kazal-like domains mediate the serine protease inhibitor activity.

9031:SLC16A8
gene id: 9031:SLC16A8
uniprot id: Q90632
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: First detected at embryonic day 5 (5 dpc) in both apical and basolateral membranes. By 14 dpc the distribution is restricted to the basolateral surface of retinal pigment epithelium. Restricted to the basolateral membrane in adult.
messages: Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (Probable). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity).
messages: Retinal pigment epithelium.
messages: The two basolateral sorting signals (BSS) are required to direct SLC16A8 to the basolateral membrane.

9031:TRAPPC3L
gene id: 9031:TRAPPC3L
uniprot id: R4GMH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

9031:ARL6IP4
gene id: 9031:ARL6IP4
uniprot id: F1NPS9
uniprot id: Q5F4A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: May be involved in modulating alternative pre-mRNA splicing.
messages: Nucleus speckle
messages: nucleolus

9031:ATRX
gene id: 9031:ATRX
uniprot id: A0A1D5PZA1
uniprot id: E1C8H5
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9031:GREB1L
gene id: 9031:GREB1L
uniprot id: E1C4J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

9031:C1D
gene id: 9031:C1D
uniprot id: F1NRP5
uniprot id: Q5ZHS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9031:DYM
gene id: 9031:DYM
uniprot id: A0A3Q3ASW2
uniprot id: Q5ZLW3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dymeclin family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.
messages: Necessary for correct organization of Golgi apparatus.

9031:IKBKAP
gene id: 9031:IKBKAP
uniprot id: F1P5L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

9031:SIX3
gene id: 9031:SIX3
uniprot id: O42406
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: First detected in the corneal epithelium and lens epithelium at 6.5 dpc and 12 dpc. At 12 dpc is present in the corneal endothelium and the limbal region. After 16 dpc and at hatching (H1), expression persisted in multiple anterior segment tissues, including the lens epithelium, the corneal endothelium, the iris, and the trabecular meshwork (at protein level).
messages: Nucleus
messages: Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon (PubMed:12569128). Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner (PubMed:12050133). Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 functions also in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway. Plays a role i…

9031:LIG4
gene id: 9031:LIG4
uniprot id: F1P275
uniprot id: Q90YB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4.
messages: Interacts with XRCC4; the LIG4-XRCC4 subcomplex has a 1:2 stoichiometry (By similarity). Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (By similarity). Additional component of the NHEJ complex includes PAXX (By similarity). Following autophosphorylation, PRKDC dissociates from DNA, leading to formation of the short-range NHEJ complex, composed of LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (By similarity).
messages: Nucleus

9031:CNP1
gene id: 9031:CNP1
uniprot id: A9CDT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

9031:FOXF2
gene id: 9031:FOXF2
uniprot id: A0A1D5PD26
names: Subcellular Location Annotation
messages: Nucleus

9031:PAPOLB
gene id: 9031:PAPOLB
uniprot id: A0A1D5P5T8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

9031:SOCS3
gene id: 9031:SOCS3
uniprot id: Q90X67
names: Domain
names: Function
names: PTM
names: Subunit
messages: Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and EPO receptor. Binding to JAK is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO and gp130 receptors.
messages: Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.
messages: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

9031:CPSF3
gene id: 9031:CPSF3
uniprot id: F1NKW5
names: Subcellular Location Annotation
messages: Nucleus

9031:DMAP1
gene id: 9031:DMAP1
uniprot id: E1C4L9
names: Subcellular Location Annotation
messages: Nucleus

9031:DLL4
gene id: 9031:DLL4
uniprot id: A0A3Q2TSN7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9031:NUDT1
gene id: 9031:NUDT1
uniprot id: F7BGT1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

9031:GRM5
gene id: 9031:GRM5
uniprot id: F1NWG3
uniprot id: Q98UC4
uniprot id: Q98UC5
uniprot id: Q98UC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9031:NANOG
gene id: 9031:NANOG
uniprot id: A7Y7W3
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nanog homeobox family.
messages: During embryonic development, expressed preferentially in epiblastic cells and germ cells. In pre-streak embryos, detected in the whole epiblast, but not in the forming hypoblast (stages XI through XIII) (at protein level). As the primitive streak starts to form, disappears from the primitive streak epiblast, but still expressed throughout the area pellucida epiblast (stage XIV -> 3+). At the end of gastrulation (stage 4+), quickly decreases in the epiblast and persists in a crescent anterior to the emerging head process (stages 4+ through 6). At stage 5, strongly expressed in some of the cells in the germinal crescent, probably corresponding primordial germ cells. At stage 7 (neurula stage), undetectable in differentiated cells (at protein level). As the neural plate forms (stages 6-8), expression in the epiblast is restricted to the anterior neural plate. At stage 33, still expressed in germ cells. At stages 42-43, expressed in gonads, as well as in brain, kidney and heart, but at much lower levels than in proliferating embryonic stem cells.
messages: Nucleus
messages: Strongly down-regulated during embryonic stem cell differentiation, induced either by retinoic acid treatment, or by cell adhesion prevention leading to embryoid body formation.
messages: Transcription factor required for the maintenance of pluripotency and self-renewal of embryonic stem cells.

9031:SV2C
gene id: 9031:SV2C
uniprot id: F1NCT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9031:CASP18
gene id: 9031:CASP18
uniprot id: Q4JQQ0
names: Similarity
messages: Belongs to the peptidase C14A family.

9031:SOX21
gene id: 9031:SOX21
uniprot id: Q9W7R5
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a negative regulator of transcription.
messages: Expressed predominantly in CNS.
messages: Nucleus

9031:SHFM1
gene id: 9031:SHFM1
uniprot id: Q5ZJW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

9031:MTFR2
gene id: 9031:MTFR2
uniprot id: E1BWR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9031:PCDH15
gene id: 9031:PCDH15
uniprot id: Q0ZM14
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function (By similarity).
messages: Cell membrane
messages: In the utricle, localizes to the distal region of the kinocilium and near the tips of the stereocilia.

9031:PLPPR1
gene id: 9031:PLPPR1
uniprot id: F1N9B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

9031:MRPS10
gene id: 9031:MRPS10
uniprot id: E1C1Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9031:FGF23
gene id: 9031:FGF23
uniprot id: R4GIR0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:PRMT5
gene id: 9031:PRMT5
uniprot id: Q5ZJZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

9031:PHC3
gene id: 9031:PHC3
uniprot id: F1P0K3
names: Subcellular Location Annotation
messages: Nucleus

9031:INO80
gene id: 9031:INO80
uniprot id: F1NYY9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9031:CDX4
gene id: 9031:CDX4
uniprot id: Q90Z54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9031:RABEP1
gene id: 9031:RABEP1
uniprot id: O42351
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

9031:RC3H1
gene id: 9031:RC3H1
uniprot id: A0A1D5P331
uniprot id: E1BZI9
names: Subcellular Location Annotation
messages: P-body

9031:CHMP1A
gene id: 9031:CHMP1A
uniprot id: F1NPS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9031:GPX4
gene id: 9031:GPX4
uniprot id: Q8QG67
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9031:C7orf25
gene id: 9031:C7orf25
uniprot id: A0A1D5P7R3
uniprot id: A0A3Q3AZZ9
names: Similarity
messages: Belongs to the UPF0415 family.

9031:METTL2B
gene id: 9031:METTL2B
uniprot id: Q5ZHP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. METL family.
messages: Cytoplasm
messages: Monomer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by METTL2 requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite.

9031:RFNG
gene id: 9031:RFNG
uniprot id: A0A140T8F8
uniprot id: O12972
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Detected at stage 15 in the presumptive dorsal-limb ectoderm. At stages 16-18 expression is restricted to the dorsal side with higher concentration at the dorsoventral boundary and later in the AER. Expression remains restricted to the dorsal ectoderm and the AER until stages 22-24 when it starts to fade in the dorsal ectoderm, but remains in the AER until the last stage examined (27).
messages: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Plays an important role in limb outgrowth, it directs the formation and positioning of the apical ectodermal ridge (AER), one of the key organizer centers of vertebrate limb development (PubMed:9121551, PubMed:9121552).
messages: Golgi apparatus membrane
messages: Membrane

9031:GLRX
gene id: 9031:GLRX
uniprot id: P79764
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutaredoxin family.
messages: Cytoplasm
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

9031:LOC769317
gene id: 9031:LOC769317
uniprot id: A0A1L1RTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:CHMP4C
gene id: 9031:CHMP4C
uniprot id: A0A1D5P420
names: Similarity
messages: Belongs to the SNF7 family.

9031:MAN1A2
gene id: 9031:MAN1A2
uniprot id: A0A1D5PZT0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9031:IAPP
gene id: 9031:IAPP
uniprot id: Q90743
names: Similarity
messages: Belongs to the calcitonin family.

9031:FAM208A
gene id: 9031:FAM208A
uniprot id: A0A1D5NWA9
uniprot id: A0A1D5P0K2
uniprot id: A0A1D5PF47
uniprot id: A0A1D5PTF5
names: Similarity
messages: Belongs to the TASOR family.

9031:AK6
gene id: 9031:AK6
uniprot id: Q5F4A8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9031:GADD45A
gene id: 9031:GADD45A
uniprot id: Q2HZD6
names: Similarity
messages: Belongs to the GADD45 family.

9031:FAM60A
gene id: 9031:FAM60A
uniprot id: Q5ZJV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SINHCAF family.
messages: Component of the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L, HDAC1. Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1.
messages: Nucleus
messages: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway. Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells and is essential to maintain the complex on chromatin.

9031:MUC2
gene id: 9031:MUC2
uniprot id: L7XFH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TWSG1
gene id: 9031:TWSG1
uniprot id: Q98T89
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the twisted gastrulation protein family.
messages: Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7 (By similarity).
messages: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
messages: Secreted
messages: The N-terminal domain is sufficient to interact with BMP4.

9031:TRAPPC11
gene id: 9031:TRAPPC11
uniprot id: Q5ZI89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPPC11 family.
messages: Component of the multisubunit TRAPP (transport protein particle) complex.
messages: Golgi apparatus
messages: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
messages: cis-Golgi network

9031:CENPH
gene id: 9031:CENPH
uniprot id: Q90ZF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CENP-H/MCM16 family.
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP. Interacts with NDC80.
messages: Nucleus
messages: kinetochore

9031:SUMO2
gene id: 9031:SUMO2
uniprot id: Q5ZJM9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

9031:NDUFS8
gene id: 9031:NDUFS8
uniprot id: A0A1D5PE41
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

9031:ST13P5
gene id: 9031:ST13P5
uniprot id: Q5ZLF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM10 family.
messages: Cytoplasm
messages: Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity).
messages: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).

9031:SLC27A6
gene id: 9031:SLC27A6
uniprot id: A0A3Q3AQ10
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9031:UBIAD1
gene id: 9031:UBIAD1
uniprot id: F1NST4
uniprot id: Q5ZKS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.

9031:GLB1L2
gene id: 9031:GLB1L2
uniprot id: A0A1D5PZH3
uniprot id: F1NLL2
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9031:STXBP5
gene id: 9031:STXBP5
uniprot id: A0A3Q2U138
uniprot id: A0A3Q2U1Q0
uniprot id: A0A3Q2UIP6
uniprot id: A0A3Q3AJI5
uniprot id: E1C3U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9031:RPS25
gene id: 9031:RPS25
uniprot id: F1NU56
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

9031:NAPG
gene id: 9031:NAPG
uniprot id: E1BWS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9031:NECAP1
gene id: 9031:NECAP1
uniprot id: A0A1D5P835
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9031:CAMK2N2
gene id: 9031:CAMK2N2
uniprot id: A0A1L1RTR6
names: Similarity
messages: Belongs to the CAMK2N family.

9031:HIST1H111L
gene id: 9031:HIST1H111L
uniprot id: P08287
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

9031:MPPE1
gene id: 9031:MPPE1
uniprot id: Q5ZK82
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Binds 2 manganese ions per subunit.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).
messages: cis-Golgi network membrane

9031:GPR37
gene id: 9031:GPR37
uniprot id: A1IHG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:NFKB1
gene id: 9031:NFKB1
uniprot id: Q04861
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Active NF-kappa-B is a heterodimer of an about 50 kDa DNA-binding subunit and the weak DNA-binding subunit p65. Two heterodimers might form a labile tetramer.
messages: Cytoplasm
messages: Nucleus
messages: P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA.
messages: S-nitrosylation of Cys-66 affects DNA binding.
messages: The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding by p50 homodimers, and/or transcription activation.
messages: While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing (By similarity).

9031:PGAP2
gene id: 9031:PGAP2
uniprot id: A0A1D5PFU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

9031:OVALX
gene id: 9031:OVALX
uniprot id: A0A1D5PI58
names: Similarity
messages: Belongs to the serpin family.

9031:RORBL
gene id: 9031:RORBL
uniprot id: F1P101
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:ADGRG1
gene id: 9031:ADGRG1
uniprot id: A0A1D5PP46
names: Subcellular Location Annotation
messages: Membrane
messages: Membrane raft
messages: Secreted

9031:IARS2
gene id: 9031:IARS2
uniprot id: Q5ZKA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

9031:NLGN3
gene id: 9031:NLGN3
uniprot id: D3WGL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

9031:HADH
gene id: 9031:HADH
uniprot id: E1BZH9
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9031:EYA4
gene id: 9031:EYA4
uniprot id: A0A1D5NXI7
uniprot id: A0A1D5PPX9
uniprot id: Q9YH98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity).

9031:LYRM1
gene id: 9031:LYRM1
uniprot id: E1BT52
names: Similarity
messages: Belongs to the complex I LYR family.

9031:SH3BP4
gene id: 9031:SH3BP4
uniprot id: F1P4F1
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9031:CST3
gene id: 9031:CST3
uniprot id: P01038
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Secreted
messages: This protein binds tightly to and inhibits a variety of thiol proteases including ficin, papain, and cathepsins B, C, H, and L. Although isolated from egg white, it is also present in serum.

9031:LOC107049580
gene id: 9031:LOC107049580
uniprot id: A0A3Q2UH82
names: Similarity
messages: Belongs to the BolA/IbaG family.

9031:STT3B
gene id: 9031:STT3B
uniprot id: E1BTD5
uniprot id: Q5ZKX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

9031:EFNA2
gene id: 9031:EFNA2
uniprot id: P52802
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ephrin family.
messages: Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8 (By similarity).
messages: Cell membrane
messages: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity).
messages: Expressed in a gradient across the tectum being more strongly expressed at the posterior pole.

9031:ZGPAT
gene id: 9031:ZGPAT
uniprot id: E1C285
names: Subcellular Location Annotation
messages: Nucleus

9031:MTERF2
gene id: 9031:MTERF2
uniprot id: F1NYE8
names: Similarity
messages: Belongs to the mTERF family.

9031:CMTM4
gene id: 9031:CMTM4
uniprot id: F1P203
names: Subcellular Location Annotation
messages: Membrane

9031:SH3PXD2A
gene id: 9031:SH3PXD2A
uniprot id: A0A3Q2U9A8
uniprot id: A0A3Q2U9S1
uniprot id: E1C207
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm
messages: podosome

9031:TMEM229B
gene id: 9031:TMEM229B
uniprot id: Q5F3L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

9031:UBL3
gene id: 9031:UBL3
uniprot id: Q5ZJ13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:SLC28A2
gene id: 9031:SLC28A2
uniprot id: A0A1D5P3G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9031:ACTG1
gene id: 9031:ACTG1
uniprot id: P53478
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:PGM2L1
gene id: 9031:PGM2L1
uniprot id: F1NAA5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9031:E2F7
gene id: 9031:E2F7
uniprot id: A0A1D5P6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9031:LOC396477
gene id: 9031:LOC396477
uniprot id: P02707
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Hepatic lectin is a membrane receptor protein that recognizes and binds exposed N-acetylglucosamine moieties of plasma glycoproteins, thus mediating their clearance (from the circulation) and endocytosis.
messages: Membrane
messages: Some or all of the cysteines are involved in disulfide bonds.

9031:DUS3L
gene id: 9031:DUS3L
uniprot id: F1NGP4
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

9031:FAM173B
gene id: 9031:FAM173B
uniprot id: A0A1D5PLC9
uniprot id: F1NJN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9031:RPA2
gene id: 9031:RPA2
uniprot id: Q5ZLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

9031:TMC1
gene id: 9031:TMC1
uniprot id: Q5YCC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9031:PDGFD
gene id: 9031:PDGFD
uniprot id: A0A3Q2U6E1
uniprot id: F1NPV1
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SMYD4
gene id: 9031:SMYD4
uniprot id: Q5F3V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus
messages: Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.

9031:FAM69C
gene id: 9031:FAM69C
uniprot id: F1P454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

9031:HTR7
gene id: 9031:HTR7
uniprot id: D4P5A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:LOC107049128
gene id: 9031:LOC107049128
uniprot id: E1BXV2
names: Similarity
messages: Belongs to the actin family.

9031:CCNT1
gene id: 9031:CCNT1
uniprot id: A0A3Q3ACK9
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

9031:MPHOSPH10
gene id: 9031:MPHOSPH10
uniprot id: A0A3Q2UAX9
uniprot id: F1NC78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9031:AGAP1
gene id: 9031:AGAP1
uniprot id: F1NWZ1
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9031:ENKD1
gene id: 9031:ENKD1
uniprot id: A0A3Q2UD29
names: Subcellular Location Annotation
messages: cilium axoneme

9031:NEU4
gene id: 9031:NEU4
uniprot id: F1P459
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9031:LOC771880
gene id: 9031:LOC771880
uniprot id: A0A1L1S0W6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:FBP2
gene id: 9031:FBP2
uniprot id: A0A1D5PN46
names: Similarity
messages: Belongs to the FBPase class 1 family.

9031:MOS
gene id: 9031:MOS
uniprot id: P10741
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

9031:GPCPD1
gene id: 9031:GPCPD1
uniprot id: E1BYP8
uniprot id: S5ZB27
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:GUK1
gene id: 9031:GUK1
uniprot id: A0A1D5PRY0
uniprot id: E1C038
names: Similarity
messages: Belongs to the guanylate kinase family.

9031:ARL6
gene id: 9031:ARL6
uniprot id: A0A1D5PWK2
uniprot id: A0A1L1RMR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

9031:MEF2D
gene id: 9031:MEF2D
uniprot id: A0A1D5PKS4
names: Subcellular Location Annotation
messages: Nucleus

9031:SLC2A8
gene id: 9031:SLC2A8
uniprot id: Q8AYP6
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

9031:GIP
gene id: 9031:GIP
uniprot id: A1DPK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9031:BIRC8
gene id: 9031:BIRC8
uniprot id: Q8UVF8
names: Similarity
messages: Belongs to the IAP family.

9031:FABP2
gene id: 9031:FABP2
uniprot id: Q7ZZZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9031:COX7A2
gene id: 9031:COX7A2
uniprot id: F1NWK2
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9031:SEC62
gene id: 9031:SEC62
uniprot id: Q5F3A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Part of a complex that contains SEC61, SEC62 and SEC63.
messages: Required for preprotein translocation.

9031:CNTN2
gene id: 9031:CNTN2
uniprot id: P28685
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Axon-associated cell adhesion molecule (AxCAM) which promotes neurite outgrowth by interaction with the AxCAM L1 (G4) of neuritic membrane. Contributes to the organization of axonal domains at nodes of Ranvier (By similarity).
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: The N-terminus is blocked.

9031:TINAG
gene id: 9031:TINAG
uniprot id: E1BTI7
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:ILKAP
gene id: 9031:ILKAP
uniprot id: E1BYA9
names: Similarity
messages: Belongs to the PP2C family.

9031:INCENPL
gene id: 9031:INCENPL
uniprot id: A0A1D5PDU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

9031:UBE2R2L
gene id: 9031:UBE2R2L
uniprot id: R4GIV8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:HPDL
gene id: 9031:HPDL
uniprot id: E1BX51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9031:SLC16A10
gene id: 9031:SLC16A10
uniprot id: A0A142EGP8
names: Subcellular Location Annotation
messages: Membrane

9031:PAICS
gene id: 9031:PAICS
uniprot id: A0A1D5PH07
uniprot id: P38024
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9031:KDELC1
gene id: 9031:KDELC1
uniprot id: E1BSM9
names: Similarity
messages: Belongs to the KDELC family.

9031:RSRP1
gene id: 9031:RSRP1
uniprot id: A0A1D5PEB7
names: Similarity
messages: Belongs to the RSRP family.

9031:MRPL54
gene id: 9031:MRPL54
uniprot id: R4GK77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9031:CNIH4
gene id: 9031:CNIH4
uniprot id: A0A1D5PVW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9031:MCL1
gene id: 9031:MCL1
uniprot id: A0A1L1RNM6
uniprot id: A0A1L1RUS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9031:GNPDA2
gene id: 9031:GNPDA2
uniprot id: E1C878
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9031:COG2
gene id: 9031:COG2
uniprot id: E1C7Y1
names: Similarity
messages: Belongs to the COG2 family.

9031:XKR8
gene id: 9031:XKR8
uniprot id: Q49M60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9031:GALR3
gene id: 9031:GALR3
uniprot id: B3GS82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:MAP2K1
gene id: 9031:MAP2K1
uniprot id: A0A1L1RPJ2
uniprot id: Q5ZIF0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:ATP6V1A
gene id: 9031:ATP6V1A
uniprot id: F1NBW2
uniprot id: Q90647
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP hydrolysis occurs at the interface between the nucleotide-binding domains of subunits A and B (By similarity). ATP hydrolysis triggers a conformational change in the subunits D and F, which induces a shift of subunit d (By similarity). The c-ring is subsequently rotated and results in a continuous proton translocation across the membrane (By similarity).
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity).
messages: Cytoplasm
messages: Ubiquitously expressed (both isoforms).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits (By similarity).

9031:MRE11
gene id: 9031:MRE11
uniprot id: A0A3Q2UAJ7
uniprot id: Q9IAM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN. Interacts with DCLRE1C/Artemis (By similarity).
messages: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9031:TNKS2
gene id: 9031:TNKS2
uniprot id: Q800E0
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:RBM48
gene id: 9031:RBM48
uniprot id: Q5F3S8
names: Similarity
messages: Belongs to the RBM48 family.

9031:ATP6V0B
gene id: 9031:ATP6V0B
uniprot id: A0A1L1RUN2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

9031:CHMP6
gene id: 9031:CHMP6
uniprot id: Q5ZL55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endomembrane system
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).

9031:SGSH
gene id: 9031:SGSH
uniprot id: F1NGI6
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:ELL
gene id: 9031:ELL
uniprot id: Q5ZLS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9031:SUGP2
gene id: 9031:SUGP2
uniprot id: E1C5N4
names: Subcellular Location Annotation
messages: Nucleus

9031:PCMT1
gene id: 9031:PCMT1
uniprot id: Q5F3N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.
messages: Monomer.
messages: cytosol

9031:ABHD17C
gene id: 9031:ABHD17C
uniprot id: Q5ZJX1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization.
messages: Postsynaptic density membrane
messages: Recycling endosome membrane
messages: dendritic spine

9031:MCU
gene id: 9031:MCU
uniprot id: A0A1D5P9H3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9031:RAP2C
gene id: 9031:RAP2C
uniprot id: F1P231
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

9031:PIK3R2
gene id: 9031:PIK3R2
uniprot id: E1C2C5
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9031:ATP9B
gene id: 9031:ATP9B
uniprot id: A0A1D5P8E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:LOC776719
gene id: 9031:LOC776719
uniprot id: H9KYP2
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

9031:SLC35B1
gene id: 9031:SLC35B1
uniprot id: A0A1D5PFY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9031:KPNA2
gene id: 9031:KPNA2
uniprot id: A0A1L1RX89
uniprot id: Q5ZMA9
names: Similarity
messages: Belongs to the importin alpha family.

9031:UBR2
gene id: 9031:UBR2
uniprot id: A0A1D5P284
uniprot id: E1C1D2
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9031:CCND2
gene id: 9031:CCND2
uniprot id: P49706
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
messages: Nucleus
messages: Nucleus membrane
messages: Phosphorylation at Thr-282 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex.
messages: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
messages: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-282 phosphorylation. The DCX(AMBRA1) complex represents the major regulator of CCND2 stability during the G1/S transition.

9031:S100A6
gene id: 9031:S100A6
uniprot id: Q98953
names: Function
names: Similarity
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).

9031:CETN2
gene id: 9031:CETN2
uniprot id: R4GLB5
names: Similarity
messages: Belongs to the centrin family.

9031:IL17F
gene id: 9031:IL17F
uniprot id: F1NFI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

9031:CYB5R2
gene id: 9031:CYB5R2
uniprot id: A0A1D5NTT2
uniprot id: Q5ZHX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Membrane
messages: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis and drug metabolism.

9031:TMTC4
gene id: 9031:TMTC4
uniprot id: F1P0M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9031:NEU2
gene id: 9031:NEU2
uniprot id: A0A1D5PLC0
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9031:IL4I1
gene id: 9031:IL4I1
uniprot id: E6N1V0
uniprot id: F1NM87
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

9031:SDR16C5
gene id: 9031:SDR16C5
uniprot id: Q5ZL32
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:SLC2A1
gene id: 9031:SLC2A1
uniprot id: P46896
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (PubMed:25957687).
messages: Interacts with isoform 1 of BSG.
messages: Photoreceptor inner segment
messages: Retinal cones (at protein level).

9031:SCN9A
gene id: 9031:SCN9A
uniprot id: E1C4S2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9031:NDUFAF2
gene id: 9031:NDUFAF2
uniprot id: R4GHM9
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9031:TMOD4
gene id: 9031:TMOD4
uniprot id: Q9PUQ7
names: Subcellular Location Annotation
messages: cytoskeleton

9031:FGFR2
gene id: 9031:FGFR2
uniprot id: P18461
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Monomer. Homodimer after ligand binding (By similarity).
messages: N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans.
messages: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity).
messages: Ubiquitinated. FGFR2 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation. Subject to degradation both in lysosomes and by the proteasome (By similarity).

9031:PLXND1
gene id: 9031:PLXND1
uniprot id: A0A3Q2U1R1
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:GCM2
gene id: 9031:GCM2
uniprot id: Q5TLZ8
names: Subcellular Location Annotation
messages: Nucleus

9031:MTPN
gene id: 9031:MTPN
uniprot id: Q91955
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myotrophin family.
messages: Cytoplasm
messages: Nucleus
messages: Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity).
messages: perinuclear region

9031:LOC107052805
gene id: 9031:LOC107052805
uniprot id: A0A1D5PS82
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:GFOD2
gene id: 9031:GFOD2
uniprot id: A0A3Q2UA90
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9031:GSTA2
gene id: 9031:GSTA2
uniprot id: Q08393
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Alpha family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.

9031:MIEF1
gene id: 9031:MIEF1
uniprot id: E1BVG4
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9031:PPP1R9A
gene id: 9031:PPP1R9A
uniprot id: A0A3Q2UE66
uniprot id: A0A3Q2UM45
uniprot id: E1C9E1
names: Subcellular Location Annotation
messages: cytoskeleton

9031:PRL
gene id: 9031:PRL
uniprot id: A0A0B5KZ08
uniprot id: P14676
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9031:RPL3
gene id: 9031:RPL3
uniprot id: Q5ZJZ2
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9031:FAM46A
gene id: 9031:FAM46A
uniprot id: Q5ZJ51
names: Similarity
messages: Belongs to the TENT family.

9031:PALD1
gene id: 9031:PALD1
uniprot id: Q8JHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paladin family.
messages: cytosol

9031:KBP
gene id: 9031:KBP
uniprot id: P19439
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

9031:DRD3
gene id: 9031:DRD3
uniprot id: C5HV40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

9031:ST6GALNAC4
gene id: 9031:ST6GALNAC4
uniprot id: Q704X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:CATH3
gene id: 9031:CATH3
uniprot id: C4PFJ9
uniprot id: Q2IAL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: Detected in bone marrow, liver and lung.
messages: May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).
messages: Membrane
messages: Secreted

9031:DGAT2
gene id: 9031:DGAT2
uniprot id: A0A1D5PMU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:KIT
gene id: 9031:KIT
uniprot id: Q08156
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation. Phosphorylated tyrosine residues are important for interaction with specific binding partners (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: High in the brain and testes and also present in the bursa of Fabricus, heart, kidney, lung, spleen thymus and ovary.
messages: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. KIT promotes activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor (By similarity).
messages: Ubiquitinated. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation.

9031:DHX29
gene id: 9031:DHX29
uniprot id: E1C388
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC).

9031:NCDN
gene id: 9031:NCDN
uniprot id: Q5ZIG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse
messages: Probably involved in signal transduction, in the nervous system. Required for the spatial learning process. May also be involved in neurite outgrowth (By similarity).
messages: cytosol
messages: dendrite

9031:CLCN2
gene id: 9031:CLCN2
uniprot id: R4GFW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

9031:SLC16A6
gene id: 9031:SLC16A6
uniprot id: F1P2B3
names: Subcellular Location Annotation
messages: Membrane

9031:TK2
gene id: 9031:TK2
uniprot id: Q5ZI21
names: Similarity
messages: Belongs to the DCK/DGK family.

9031:ATP5G3
gene id: 9031:ATP5G3
uniprot id: E1BV48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9031:SMPD2
gene id: 9031:SMPD2
uniprot id: A0A1D5PL80
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9031:SP3
gene id: 9031:SP3
uniprot id: Q90WR8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-541 also control transcriptional activity.
messages: Belongs to the Sp1 C2H2-type zinc-finger protein family.
messages: Interacts with HDAC1 and HDAC2; the interaction deacetylates SP3 and regulates its transcriptional activity (By similarity). Interacts with v-Jun.
messages: Nucleus
messages: PML body
messages: Sumoylation represses transcriptional activity. Lys-541 is the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Alternate sumoylation and acetylation at Lys-541 also control transcriptional activity (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription.

9031:ARL5B
gene id: 9031:ARL5B
uniprot id: E1BQL0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9031:LIN54
gene id: 9031:LIN54
uniprot id: A0A1D5P487
uniprot id: F1NCE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9031:OGFOD1
gene id: 9031:OGFOD1
uniprot id: F1NBM0
names: Similarity
messages: Belongs to the TPA1 family.

9031:RGS17
gene id: 9031:RGS17
uniprot id: Q9PWA0
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with GNAI1 and GNAQ (By similarity). Interacts with GNAZ and GNAI2. Forms a complex with mu-opioid receptors and G(alpha)z/i2 subunits, including GNAZ and GNAI2; the formation of this complex results in mu-opioid receptor desensitization (By similarity).
messages: Membrane
messages: N- and O-glycosylated in synapsomal membranes.
messages: Nucleus
messages: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
messages: Serine phosphorylated in synapsomal membranes.
messages: Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits.
messages: synaptosome

9031:CTSZ
gene id: 9031:CTSZ
uniprot id: E1C4M3
names: Similarity
messages: Belongs to the peptidase C1 family.

9031:PFDN5
gene id: 9031:PFDN5
uniprot id: A0A1D5NXK7
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

9031:NXPH2
gene id: 9031:NXPH2
uniprot id: R4GG19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9031:NXPE3
gene id: 9031:NXPE3
uniprot id: E1C8F5
names: Similarity
messages: Belongs to the NXPE family.

9031:GIPC2
gene id: 9031:GIPC2
uniprot id: F1NKY8
names: Similarity
messages: Belongs to the GIPC family.

9031:MRPL10
gene id: 9031:MRPL10
uniprot id: H9L0I5
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

9031:SLC51A
gene id: 9031:SLC51A
uniprot id: E1C4J6
names: Subcellular Location Annotation
messages: Membrane

9031:CLEC18B
gene id: 9031:CLEC18B
uniprot id: R4GI94
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:METTL15P1
gene id: 9031:METTL15P1
uniprot id: A0A1D5PLE8
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9031:GJB6
gene id: 9031:GJB6
uniprot id: O93533
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Exclusively expressed in the cochlea of the inner ear, where it is found in cells of the tegmentum vasculosum, cuboidal cells, supporting cells and clear cells.
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: Specifically expressed at the late developmental stages in the cochlea.
messages: gap junction

9031:PTGER3
gene id: 9031:PTGER3
uniprot id: Q1KMR2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:UQCRFS1
gene id: 9031:UQCRFS1
uniprot id: Q5ZLR5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit. Fe-S cluster delivery to the Rieske protein is mediated by components of the iron sulfur (Fe-S) cluster assembly machinery that reside in the mitochondrial matrix (including HSC20 and LYRM7) (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Incorporation of the Rieske protein UQCRFS1 is the penultimate step in complex III assembly. Interacts with TTC19, which is involved in the clearance of UQCRFS1 fragments (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). Subunit 9 corresponds to the mitochondrial targeting sequence (MTS) of Rieske protein UQCRFS1. It is retained after processing and incorporated inside complex III, where it remains bound to the complex and localizes between the 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS) (By similarity). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (By similarity).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity).
messages: Mitochondrion inner membrane
messages: Proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer. Several fragments are generated during UQCRFS1 insertion, most probably due to the endogenous matrix-processing peptidase (MPP) activity of the 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, which are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively. The action of the protease is also necessary for the clearance of the UQCRFS1 fragments.
messages: Several peptides are generated during UQCRFS1 insertion. According to some authors, the identification of the transit peptide as the subunit 9, does not necessary imply that it must be considered as a structural subunit of the complex III dimer as additional fragments from UQCRFS1 are also present.
messages: The Rieske protein is a high potential 2Fe-2S protein.

9031:TRPM8
gene id: 9031:TRPM8
uniprot id: Q5UKZ3
names: Subcellular Location Annotation
messages: Membrane

9031:LGALS3
gene id: 9031:LGALS3
uniprot id: A4GTP0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9031:NMU
gene id: 9031:NMU
uniprot id: A0A1D5PLD5
uniprot id: F1NEH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9031:DOK1
gene id: 9031:DOK1
uniprot id: A0A1D5PZ39
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9031:POLH
gene id: 9031:POLH
uniprot id: Q5ZIW9
names: Subcellular Location Annotation
messages: Nucleus

9031:TNNT2
gene id: 9031:TNNT2
uniprot id: A0A1D5PBV6
uniprot id: P02642
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9031:SEPTIN2
gene id: 9031:SEPTIN2
uniprot id: E1C3D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium membrane
messages: spindle

9031:DDX11
gene id: 9031:DDX11
uniprot id: A0A3Q2UC34
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.

9031:SLC1A3
gene id: 9031:SLC1A3
uniprot id: A0A3Q2U6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9031:TMEM45L
gene id: 9031:TMEM45L
uniprot id: E1BSJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9031:MYO1D
gene id: 9031:MYO1D
uniprot id: A0A3Q2TZ02
uniprot id: A0A3Q2TZW8
uniprot id: E1C459
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:PMPCA
gene id: 9031:PMPCA
uniprot id: Q5ZJ49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

9031:CYP7A1
gene id: 9031:CYP7A1
uniprot id: Q76CE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9031:DIP2C
gene id: 9031:DIP2C
uniprot id: A0A1D5P145
names: Similarity
messages: Belongs to the DIP2 family.

9031:CTSA
gene id: 9031:CTSA
uniprot id: A0A1L1RKJ5
uniprot id: Q5ZIJ5
names: Similarity
messages: Belongs to the peptidase S10 family.

9031:IFITM10
gene id: 9031:IFITM10
uniprot id: A0A1D5NV57
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9031:COR1
gene id: 9031:COR1
uniprot id: P37067
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Odorant receptor.

9031:MED17
gene id: 9031:MED17
uniprot id: Q5ZID1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

9031:ICOS
gene id: 9031:ICOS
uniprot id: A6PZH9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

9031:VAMP1
gene id: 9031:VAMP1
uniprot id: A0A3Q3B1A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9031:YWHAB
gene id: 9031:YWHAB
uniprot id: Q5ZLQ6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.
messages: Phosphorylated.

9031:IL8L1
gene id: 9031:IL8L1
uniprot id: O73912
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

9031:GDAP1
gene id: 9031:GDAP1
uniprot id: A0A1D5NWZ6
names: Similarity
messages: Belongs to the GST superfamily.

9031:POLR2F
gene id: 9031:POLR2F
uniprot id: Q9PT88
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

9031:MRPL28
gene id: 9031:MRPL28
uniprot id: F6UK13
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9031:CUL4B
gene id: 9031:CUL4B
uniprot id: E1BQK9
names: Similarity
messages: Belongs to the cullin family.

9031:FOXC1
gene id: 9031:FOXC1
uniprot id: O93440
names: Subcellular Location Annotation
messages: Nucleus

9031:TBPL2
gene id: 9031:TBPL2
uniprot id: A6H910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

9031:RNF175
gene id: 9031:RNF175
uniprot id: F1ND46
names: Subcellular Location Annotation
messages: Membrane

9031:LOC100857573
gene id: 9031:LOC100857573
uniprot id: A0A1D5PZA0
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9031:BIRC7
gene id: 9031:BIRC7
uniprot id: E1C5V5
names: Similarity
messages: Belongs to the IAP family.

9031:BTC
gene id: 9031:BTC
uniprot id: Q64EU6
uniprot id: Q6B4U6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:FAM91A1
gene id: 9031:FAM91A1
uniprot id: A0A1D5NU70
names: Similarity
messages: Belongs to the FAM91 family.

9031:PCNX4
gene id: 9031:PCNX4
uniprot id: F1NF96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9031:ERMN
gene id: 9031:ERMN
uniprot id: A0A1L1RRV4
names: Function
names: Subunit
messages: Binds actin.
messages: Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.

9031:TOM1
gene id: 9031:TOM1
uniprot id: A0A3Q2UMT0
uniprot id: O12940
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (By similarity). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (By similarity). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (By similarity). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). Binds to polyubiquitinated proteins via its GAT domain (By similarity). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (By similarity). Mediates clathrin recruitment to early endosomes (By similarity). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (By similarity). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (By similarity). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (By similarity). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (By similarity).
messages: Belongs to the TOM1 family.
messages: Cytoplasm
messages: Early endosome membrane
messages: Endosome membrane
messages: Expression is cooperatively activated by MYB and CEBPG.
messages: Found in a complex with TOLLIP; interacts (via GAT domain) with TOLLIP (via N-terminus); the interactions leads to TOM1-recruitment to endosomes and inhibition of TOLLIP binding to PtdIns(3)P (By similarity). Interacts (via GAT domain and the C-terminal part of the VHS domain) with UBC/ubiquitin (By similarity). Interacts (via clathrin box and C-terminus) with clathrin heavy chain (By similarity). Interacts with MYO6 (By similarity).
messages: Monoubiquitinated.
messages: The GAT domain and the VHS domain are required for the interaction with polyubiquitinated proteins.
messages: The VHS domain binds to phosphatidylinositol monophosphates (By similarity). The KRKK motif within the VHS domain is required for binding to phosphatidylinositol monophosphates, with a preference for phosphatidylinositol 5-phosphate (PtdIns(5)P) (By similarity).

9031:CDC42SE2
gene id: 9031:CDC42SE2
uniprot id: R4GLC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9031:ASB8
gene id: 9031:ASB8
uniprot id: A0A1D5NZD2
uniprot id: Q5ZHY6
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9031:SH3PXD2B
gene id: 9031:SH3PXD2B
uniprot id: E1C4J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm
messages: podosome

9031:SPATA6
gene id: 9031:SPATA6
uniprot id: A0A1L1RNF7
names: Similarity
messages: Belongs to the SPATA6 family.

9031:CDC42EP4
gene id: 9031:CDC42EP4
uniprot id: A0A1L1RMX6
uniprot id: E1BUR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9031:EIF2B2
gene id: 9031:EIF2B2
uniprot id: A0A1D5PPG6
uniprot id: Q5ZL25
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

9031:LAPTM4A
gene id: 9031:LAPTM4A
uniprot id: Q5ZML7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAPTM4/LAPTM5 transporter family.
messages: Endomembrane system
messages: May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.
messages: The C-terminal domain is necessary for retention within intracellular membranes.

9031:STXBP1
gene id: 9031:STXBP1
uniprot id: A0A1D5PHU2
uniprot id: A0A1D5PK28
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9031:UNC93B1
gene id: 9031:UNC93B1
uniprot id: A0A1D5PAL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9031:ANXA13
gene id: 9031:ANXA13
uniprot id: A0A1D5NUB1
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9031:CARNMT1
gene id: 9031:CARNMT1
uniprot id: A0A0G3FDI9
uniprot id: F1N9S8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carnosine N-methyltransferase family.
messages: Homodimer. Each monomer accommodates one molecule of carnosine in its active pocket, precisely anchoring the histidine imidazole ring such that only N1 is exposed and deprotonated for methylation.
messages: N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
messages: Nucleus
messages: The Gly-Xaa-Gly-Xaa-Gly (GXGXG) motif binds the adenosyl part of S-adenosyl-L-methionine.
messages: The carnosine-binding region forms hydrophobic and hydrogen bonds with carnosine, defining a flipping orientation of the imidazole ring so that N1 is present next to S-adenosyl-L-methionine for methylation.
messages: Two different proteins belonging to two different protein families are able to mediate carnosine N-methyltransferase activity in chicken. This protein, which is conserved from human to yeast, and another protein (AC U3NEE3), which is not conserved in mammals.
messages: cytosol

9031:SULT6B1L
gene id: 9031:SULT6B1L
uniprot id: A0A1L1RLU1
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:S100A12
gene id: 9031:S100A12
uniprot id: P28318
names: Similarity
names: Tissue Specificity
messages: Belongs to the S-100 family.
messages: Expressed in v-myb-transformed myelomonocytic cells.

9031:OLIG2
gene id: 9031:OLIG2
uniprot id: Q90XB3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for oligodendrocyte and motor neuron specification in the spinal cord.

9031:TFB2M
gene id: 9031:TFB2M
uniprot id: F1NSS3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

9031:ERCC3
gene id: 9031:ERCC3
uniprot id: F1NZ23
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

9031:SMAD5
gene id: 9031:SMAD5
uniprot id: Q56I99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: May form trimers with the co-SMAD SMAD4.
messages: Nucleus
messages: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity).

9031:SLC6A6
gene id: 9031:SLC6A6
uniprot id: F1P1E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

9031:PSMD9
gene id: 9031:PSMD9
uniprot id: Q5ZJS1
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9031:PDE5A
gene id: 9031:PDE5A
uniprot id: S4SCC1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:APOD
gene id: 9031:APOD
uniprot id: Q5G8Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9031:SMAD3
gene id: 9031:SMAD3
uniprot id: P84023
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Interacts with SARA (SMAD anchor for receptor activation); form trimers with another SMAD3 and the co-SMAD SMAD4.
messages: Nucleus
messages: Phosphorylated on serine by TGF-beta and activin type 1 receptor kinases.
messages: The MH2 domain is sufficient to carry protein nuclear export.
messages: Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity).

9031:TRIM9
gene id: 9031:TRIM9
uniprot id: A0A3Q2U2G8
names: Subcellular Location Annotation
messages: cytoskeleton

9031:TAF12
gene id: 9031:TAF12
uniprot id: Q5ZKX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9031:SENP8
gene id: 9031:SENP8
uniprot id: R4GKQ2
names: Similarity
messages: Belongs to the peptidase C48 family.

9031:FGD3
gene id: 9031:FGD3
uniprot id: A0A1D5NVP9
uniprot id: F1P409
names: Subcellular Location Annotation
messages: cytoskeleton

9031:APOLD1
gene id: 9031:APOLD1
uniprot id: A0A3Q2UFK3
names: Similarity
messages: Belongs to the apolipoprotein L family.

9031:NHEJ1
gene id: 9031:NHEJ1
uniprot id: A0A3Q2UFN5
uniprot id: F1NVP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Membrane
messages: Nucleus

9031:HOXC9
gene id: 9031:HOXC9
uniprot id: A0A1D5PQW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:TM4SF1a
gene id: 9031:TM4SF1a
uniprot id: R4GLJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9031:BCHE
gene id: 9031:BCHE
uniprot id: A0A3Q2UC01
uniprot id: F1NV99
uniprot id: Q90ZK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9031:DUSP5
gene id: 9031:DUSP5
uniprot id: A0A1D5P5S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9031:UNG
gene id: 9031:UNG
uniprot id: Q8AYC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

9031:MIS18A
gene id: 9031:MIS18A
uniprot id: E1BQA3
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9031:ADPRM
gene id: 9031:ADPRM
uniprot id: A0A1D5PMT3
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9031:SPAST
gene id: 9031:SPAST
uniprot id: A0A1L1RV27
uniprot id: Q5ZK92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.
messages: Belongs to the AAA ATPase family.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules.
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cytoskeleton
messages: perinuclear region

9031:ZFHX3
gene id: 9031:ZFHX3
uniprot id: A0A1D5NZZ5
names: Subcellular Location Annotation
messages: Nucleus

9031:F13B
gene id: 9031:F13B
uniprot id: F1NZ84
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:PIP4K2A
gene id: 9031:PIP4K2A
uniprot id: Q5F356
names: Activity Regulation
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: In rod outer segments, activated by light.
messages: Lysosome
messages: Nucleus
messages: Phosphorylated in tyrosines. Phosphorylation is induced by light and increases kinase activity.

9031:PXMP4
gene id: 9031:PXMP4
uniprot id: E1C5N7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

9031:GGA3
gene id: 9031:GGA3
uniprot id: Q5F496
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

9031:NR0B2
gene id: 9031:NR0B2
uniprot id: F1NCW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

9031:PDGFC
gene id: 9031:PDGFC
uniprot id: Q9I946
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Expression increases in the spinal cord from 4 dpc to 16 dpc, with the highest level detected between 12 dpc and 16 dpc. Expression rapidly decreases after hatching.
messages: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, in angiogenesis and blood vessel development (By similarity).
messages: Homodimer; disulfide-linked. Interacts with PDGFRA homodimers, and with heterodimers formed by PDGFRA and PDGFRB (By similarity).
messages: Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form (By similarity).
messages: Secreted

9031:GADL1
gene id: 9031:GADL1
uniprot id: F1P1L4
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9031:DNAJB6
gene id: 9031:DNAJB6
uniprot id: Q5F3Z5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity.
messages: Homooligomer.
messages: Nucleus
messages: perinuclear region

9031:KMO
gene id: 9031:KMO
uniprot id: F1NM78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Mitochondrion outer membrane

9031:SH3GL1
gene id: 9031:SH3GL1
uniprot id: Q8AXV0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Early endosome membrane
messages: Expressed throughout follicle development with highest level in small white follicles. Expressed in granulosa cells, theca cells and post-ovulatory sacs of developing follicles.
messages: Highest level in central region of the theca of developing follicles (at protein level). Expressed at highest level in brain and testis, at high level in kidney, lung and stroma, low level in spleen and adrenal gland (at protein level). Expressed in most tissue with highest levels in small ovarian follicles, brain and testis.
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
messages: Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1.
messages: podosome

9031:RB1
gene id: 9031:RB1
uniprot id: Q90600
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: (Microbial infection) Interacts with, and is inhibited by fowl adenovirus 1 protein GAM-1.
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Interacts with and sequesters the E2F1 transcription factor. Interacts with SUV39H1, KMT5B and KMT5C (By similarity).
messages: Nucleus
messages: Phosphorylated in G1, thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. Phosphorylation of domain C promotes interaction between the C-terminal domain C and the Pocket domain, and thereby inhibits interactions with heterodimeric E2F/DP transcription factor complexes (By similarity).
messages: Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C.

9031:MRPS16
gene id: 9031:MRPS16
uniprot id: E1C907
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

9031:DIP2B
gene id: 9031:DIP2B
uniprot id: A0A3Q2U035
names: Similarity
messages: Belongs to the DIP2 family.

9031:CCNE2
gene id: 9031:CCNE2
uniprot id: Q5ZMH4
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

9031:HOXA13
gene id: 9031:HOXA13
uniprot id: Q90X25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Abd-B homeobox family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:SRRD
gene id: 9031:SRRD
uniprot id: F1NQQ0
names: Similarity
messages: Belongs to the SRR1 family.

9031:BFSP1
gene id: 9031:BFSP1
uniprot id: Q06637
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Detected in eye lens fiber cells (at protein level). Detected in embryonic eye lens.
messages: Required for the correct formation of lens intermediate filaments.
messages: cell cortex
messages: cytoskeleton

9031:ST6GALNAC6
gene id: 9031:ST6GALNAC6
uniprot id: A0A3Q2UCV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:SBF1
gene id: 9031:SBF1
uniprot id: A0A1D5NV84
uniprot id: A0A1D5PEM8
uniprot id: A0A1D5PSZ3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9031:PRDM16
gene id: 9031:PRDM16
uniprot id: A0A3Q3AHL1
names: Subcellular Location Annotation
messages: Nucleus

9031:TMEM231
gene id: 9031:TMEM231
uniprot id: F1NNL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM231 family.
messages: Part of the tectonic-like complex (also named B9 complex).
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: cilium membrane

9031:ADGRG5
gene id: 9031:ADGRG5
uniprot id: F1P3R6
names: Subcellular Location Annotation
messages: Membrane

9031:UBA2
gene id: 9031:UBA2
uniprot id: F1P226
uniprot id: Q5ZKH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

9031:ATP13A3
gene id: 9031:ATP13A3
uniprot id: A0A3Q3AE24
uniprot id: A0A3Q3ASK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9031:HYAL2
gene id: 9031:HYAL2
uniprot id: H9KZ20
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9031:LHX5
gene id: 9031:LHX5
uniprot id: E1BQX0
names: Subcellular Location Annotation
messages: Nucleus

9031:SCN2A
gene id: 9031:SCN2A
uniprot id: E1BQT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9031:ANXA8L1
gene id: 9031:ANXA8L1
uniprot id: E1C8K3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9031:WEE2
gene id: 9031:WEE2
uniprot id: R9PXP6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

9031:CLK4
gene id: 9031:CLK4
uniprot id: E1C4D8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:CENPM
gene id: 9031:CENPM
uniprot id: Q1T7B9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: Component of the CENPA-HI complex, at least composed of CENPH, CENPI, CENPK, CENPL, CENPM, CENPO and CENPP.
messages: Nucleus
messages: centromere

9031:CCR7
gene id: 9031:CCR7
uniprot id: E3VW39
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:CKS2
gene id: 9031:CKS2
uniprot id: A0A1D5PGD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9031:TDP1
gene id: 9031:TDP1
uniprot id: A0A3Q2TZJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9031:PSMB3
gene id: 9031:PSMB3
uniprot id: E1BYW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9031:TRAF2
gene id: 9031:TRAF2
uniprot id: A0A090JQG8
uniprot id: A0A3Q2U6P9
uniprot id: E1BTY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9031:RBM17
gene id: 9031:RBM17
uniprot id: E1BUJ1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9031:CSTF3
gene id: 9031:CSTF3
uniprot id: Q5F4A0
names: Subcellular Location Annotation
messages: Nucleus

9031:MCHR2
gene id: 9031:MCHR2
uniprot id: B3GRU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:TFAP2D
gene id: 9031:TFAP2D
uniprot id: A0A1D5P457
uniprot id: B5LEQ3
names: Similarity
messages: Belongs to the AP-2 family.

9031:EMX2
gene id: 9031:EMX2
uniprot id: A0A3Q2TSV2
names: Subcellular Location Annotation
messages: Nucleus

9031:ATP10A
gene id: 9031:ATP10A
uniprot id: A0A1D5PHS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9031:MPI
gene id: 9031:MPI
uniprot id: A0A1D5Q008
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9031:PROC
gene id: 9031:PROC
uniprot id: F1NGY6
uniprot id: Q804X5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:FBLN1
gene id: 9031:FBLN1
uniprot id: A0A1L1RU28
uniprot id: O73775
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:POT1
gene id: 9031:POT1
uniprot id: P62597
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the telombin family.
messages: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex that is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to at least two telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand). Its activity is TERT dependent but it does not increase TERT activity (By similarity).
messages: Homodimer or homooligomer. Component of the telomerase ribonucleoprotein complex. Binds single-stranded telomeric DNA as a monomer (By similarity). Found in a complex with TERF1, TINF2 and TNKS1. Interacts with TNKS1 (By similarity).
messages: Nucleus
messages: telomere

9031:SYP
gene id: 9031:SYP
uniprot id: F6U685
uniprot id: Q90661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9031:CDH7
gene id: 9031:CDH7
uniprot id: Q90763
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
messages: Cell membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:GFRA3
gene id: 9031:GFRA3
uniprot id: F1NKR0
names: Similarity
messages: Belongs to the GDNFR family.

9031:SSTR3
gene id: 9031:SSTR3
uniprot id: Q4ZJF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:GUCA2B
gene id: 9031:GUCA2B
uniprot id: R4GIC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9031:BMPR1B
gene id: 9031:BMPR1B
uniprot id: F1NTD3
uniprot id: Q05438
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcription (By similarity). Positively regulates chondrocyte differentiation (PubMed:24129431, PubMed:14523231).

9031:HPS5
gene id: 9031:HPS5
uniprot id: A0A1D5PX82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9031:RCAN1
gene id: 9031:RCAN1
uniprot id: E1BUP1
names: Similarity
messages: Belongs to the RCAN family.

9031:SUSD6
gene id: 9031:SUSD6
uniprot id: A0A1D5PFT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:HOXA6
gene id: 9031:HOXA6
uniprot id: Q5YLH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:MIOS
gene id: 9031:MIOS
uniprot id: F1NS24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

9031:NKIRAS2
gene id: 9031:NKIRAS2
uniprot id: Q5ZJW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation.
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
messages: Cytoplasm
messages: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

9031:GPHN
gene id: 9031:GPHN
uniprot id: A0A3Q2U7L3
names: Similarity
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9031:RRAGC
gene id: 9031:RRAGC
uniprot id: A0A1D5PLJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9031:EZH1
gene id: 9031:EZH1
uniprot id: A0A1D5PTZ6
names: Subcellular Location Annotation
messages: Nucleus

9031:PLIN2
gene id: 9031:PLIN2
uniprot id: F7BYG6
uniprot id: Q5F3Y4
names: Similarity
messages: Belongs to the perilipin family.

9031:MTG2
gene id: 9031:MTG2
uniprot id: F1NVX4
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9031:CMC4
gene id: 9031:CMC4
uniprot id: F1P3A7
names: Similarity
messages: Belongs to the CMC4 family.

9031:ARHGDIA
gene id: 9031:ARHGDIA
uniprot id: F1P3P3
uniprot id: Q5ZMT1
names: Similarity
messages: Belongs to the Rho GDI family.

9031:PADI1
gene id: 9031:PADI1
uniprot id: E1C0W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Cytoplasm

9031:EPHA4
gene id: 9031:EPHA4
uniprot id: A0A1D5PNP7
uniprot id: Q07496
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Expressed at high levels in brain, with expression also detected in the kidney, lung, muscle and thymus.
messages: Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602 (By similarity). Interacts (via PDZ motif) with SIPA1L1 (via PDZ domain); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases.
messages: Membrane
messages: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections (By similarity).

9031:HBS1L
gene id: 9031:HBS1L
uniprot id: E1BW59
names: Subunit
messages: Interacts with the SKI complex.

9031:DTD1
gene id: 9031:DTD1
uniprot id: E1BRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

9031:RNF20
gene id: 9031:RNF20
uniprot id: F1N9A6
uniprot id: Q5ZLS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively).
messages: Component of the RNF20/40 complex (also known as BRE1 complex).
messages: Nucleus

9031:HOXB3
gene id: 9031:HOXB3
uniprot id: A0A1D5NXL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9031:ARL8B
gene id: 9031:ARL8B
uniprot id: F1P0Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9031:GPS1
gene id: 9031:GPS1
uniprot id: Q5ZLU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN1 family.
messages: Cytoplasm
messages: Nucleus

9031:C8orf22
gene id: 9031:C8orf22
uniprot id: A0A1D5P8M4
names: Similarity
messages: Belongs to the PPDPF family.

9031:SLIT3
gene id: 9031:SLIT3
uniprot id: F1NF14
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:TNFRSF9
gene id: 9031:TNFRSF9
uniprot id: A0A3Q2UM48
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:LOC769139
gene id: 9031:LOC769139
uniprot id: H9L110
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:SEC61B
gene id: 9031:SEC61B
uniprot id: F1NWX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

9031:TMEM237
gene id: 9031:TMEM237
uniprot id: R4GF30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

9031:MPDZ
gene id: 9031:MPDZ
uniprot id: A0A3Q2U267
uniprot id: F1N9G0
uniprot id: G1JT17
names: Subcellular Location Annotation
messages: tight junction

9031:NPY6R
gene id: 9031:NPY6R
uniprot id: Q2I810
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:TARSL2
gene id: 9031:TARSL2
uniprot id: F1P372
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9031:RPS13
gene id: 9031:RPS13
uniprot id: Q6ITC7
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9031:SIM1
gene id: 9031:SIM1
uniprot id: E1C5G3
names: Subcellular Location Annotation
messages: Nucleus

9031:IL6ST
gene id: 9031:IL6ST
uniprot id: Q9W6U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

9031:CCDC85C
gene id: 9031:CCDC85C
uniprot id: E1C6L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9031:FBXO31
gene id: 9031:FBXO31
uniprot id: A0A3Q2UD36
uniprot id: E1C5T0
names: Similarity
names: Subunit
messages: Belongs to the FBXO31 family.
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

9031:PAX6
gene id: 9031:PAX6
uniprot id: O42348
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:MED4
gene id: 9031:MED4
uniprot id: A0A1D5P8W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:PRKAR1A
gene id: 9031:PRKAR1A
uniprot id: Q5ZM91
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules (By similarity).
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain but is not phosphorylated. The physiological significance of phosphorylations by other kinases is unclear (By similarity).

9031:MAN2B2
gene id: 9031:MAN2B2
uniprot id: F1NQF6
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9031:SMC4
gene id: 9031:SMC4
uniprot id: F1NDN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

9031:RALY
gene id: 9031:RALY
uniprot id: A0A1D5PSH2
uniprot id: A0A3Q2U2Y0
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9031:SMIM19
gene id: 9031:SMIM19
uniprot id: A0A1D5PP98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

9031:GABRQ
gene id: 9031:GABRQ
uniprot id: P24045
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB4 sub-subfamily.
messages: Cell membrane
messages: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
messages: Postsynaptic cell membrane

9031:CD8BP
gene id: 9031:CD8BP
uniprot id: F6RFK3
uniprot id: Q90769
names: Subcellular Location Annotation
messages: Membrane

9031:USB1
gene id: 9031:USB1
uniprot id: A0A1D5P2D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.

9031:TAF15
gene id: 9031:TAF15
uniprot id: E1BT66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

9031:HPGDS
gene id: 9031:HPGDS
uniprot id: O73888
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the GST superfamily. Sigma family.
messages: Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide.
messages: Cytoplasm
messages: Glutathione is required for the prostaglandin D synthase activity.
messages: Highly expressed in liver, kidney, small intestine and colon, moderately in pancreas, bone marrow, lung and ovary, and expressed at low levels in spleen, thymus, heart and brain. Not detected in oviduct or skin (at protein level) (PubMed:9657971). Expressed in liver (PubMed:11572089).
messages: Significantly increased expression by estrogen. Up-regulated after 1 hour of exposure to estrogen. Expression persists through 72 hours.

9031:ACSL5
gene id: 9031:ACSL5
uniprot id: Q5ZIG7
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

9031:CCR6
gene id: 9031:CCR6
uniprot id: B0BL89
uniprot id: F1NPD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

9031:SNTG1
gene id: 9031:SNTG1
uniprot id: A0A1D5NVQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9031:SFN
gene id: 9031:SFN
uniprot id: R4GF89
names: Similarity
messages: Belongs to the 14-3-3 family.

9031:SMAD6
gene id: 9031:SMAD6
uniprot id: C3U1W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9031:SLC39A9
gene id: 9031:SLC39A9
uniprot id: C4N9M9
uniprot id: Q5ZIU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

9031:CHRNB2
gene id: 9031:CHRNB2
uniprot id: P09484
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.
messages: Cell membrane
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains. The pentamer alpha3-beta-2 interacts with the conotoxin BuIA and the conotoxin MII (By similarity).
messages: Postsynaptic cell membrane

9031:FSCN2
gene id: 9031:FSCN2
uniprot id: D5LHI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9031:LOC427656
gene id: 9031:LOC427656
uniprot id: A0A3Q2UAX1
names: Subcellular Location Annotation
messages: Nucleus

9031:CHRNA7
gene id: 9031:CHRNA7
uniprot id: F1P4Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:A4GNT
gene id: 9031:A4GNT
uniprot id: F1P4K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9031:KCNH1
gene id: 9031:KCNH1
uniprot id: A0A1D5P1M1
names: Subcellular Location Annotation
messages: Membrane

9031:AZIN2
gene id: 9031:AZIN2
uniprot id: A0A1D5PTD4
uniprot id: E1C5E7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9031:MPPED2
gene id: 9031:MPPED2
uniprot id: E1BXB8
names: Similarity
messages: Belongs to the UPF0046 family.

9031:LOC421690
gene id: 9031:LOC421690
uniprot id: E1BWT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Membrane
messages: Vacuole membrane

9031:BMP4
gene id: 9031:BMP4
uniprot id: E1C0T2
names: Similarity
messages: Belongs to the TGF-beta family.

9031:LOC101747660
gene id: 9031:LOC101747660
uniprot id: R4GII9
names: Similarity
messages: Belongs to the threonine aldolase family.

9031:PPP4R2
gene id: 9031:PPP4R2
uniprot id: Q5ZMU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP4R2 family.
messages: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

9031:CDX2
gene id: 9031:CDX2
uniprot id: P79788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9031:SH3BGRL3
gene id: 9031:SH3BGRL3
uniprot id: A0A1L1RWM3
names: Similarity
messages: Belongs to the SH3BGR family.

9031:H2AFY
gene id: 9031:H2AFY
uniprot id: O93327
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ADP-ribosylated.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: In contrast to isoform 1, does not bind poly-ADP-ribose.
messages: Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism. Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them. This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration.
messages: Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin.
messages: Nucleus
messages: Present in immature erythrocytes (at protein level).
messages: Present in liver (at protein level).
messages: The macro domain specifically binds poly-ADP-ribose.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

9031:ST6GALNAC1
gene id: 9031:ST6GALNAC1
uniprot id: Q92183
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 29 family.
messages: Embryo.
messages: Golgi apparatus membrane
messages: Heart, kidney, testes, brain, liver and lung.
messages: Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (By similarity). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:8288607).

9031:EPHB6
gene id: 9031:EPHB6
uniprot id: F1NAX7
uniprot id: Q07497
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Membrane
messages: Most abundant in thymus and detectable in brain, retina, kidney, lung and heart. Not detected in skeletal muscle and liver.
messages: Receptor for members of the ephrin-B family.

9031:MYO6
gene id: 9031:MYO6
uniprot id: Q9I8D1
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-binding linker domain and a single IQ motif, and a C-terminal tail region with a three-helix bundle region, a SAH domain and a unique globular domain required for interaction with other proteins such as cargo-binding.
messages: Golgi apparatus
messages: Homodimer; dimerization seems to implicate the unfolding of the three-helix bundle region creating an additional calmodulin binding site, and cargo binding (By similarity). Able to function as a monomer under specific conditions in vitro (By similarity). Forms a complex with CFTR and DAB2 in the apical membrane of epithelial cells (By similarity). Binding to calmodulin through a unique insert, not found in other myosins, located in the neck region between the motor domain and the IQ domain appears to contribute to the directionality reversal (By similarity). This interaction occurs only if the C-terminal lobe of calmodulin is occupied by calcium (By similarity). Interaction with F-actin/ACTN1 occurs only at the apical brush border domain of the proximal tubule cells (By similarity). Interacts with DAB2 (By similarity). In vitro, the C-terminal globular tail binds a C-terminal region of DAB2 (By similarity). Interacts with CFTR (By similarity). Interacts with OPTN (PubMed:15837803). Interacts with CABP5 (By similarity). Interacts (via residues 1139-1257) with TOM1 (via residues 397-488) (By similarity). Interacts with TAX1BP1 and CALCOCO2/NDP52 (By similarity). Interacts with TOM1L2 (By similarity).
messages: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (By similarity). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (By similarity). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). May act as a regulator of F-actin dynamics (By similarity). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Modulates RNA polymerase II-dependent transcription (By similarity).
messages: Nucleus
messages: Originally predicted to contain a coiled coil domain but generally accepted to contain a stable SAH domain instead.
messages: Phosphorylation in the motor domain, induced by EGF, results in translocation of MYO6 from the cell surface to membrane ruffles. Phosphorylated in vitro by p21-activated kinase (PAK).
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-6 (MYH6).
messages: The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds (By similarity). Its contribution to the mechanism confering the myosin movement on actin filaments is debated (By similarity).
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: clathrin-coated vesicle membrane
messages: cytosol
messages: filopodium
messages: microvillus
messages: perinuclear region
messages: ruffle membrane
messages: trans-Golgi network membrane

9031:RPL32
gene id: 9031:RPL32
uniprot id: E1BVB1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9031:EEF2K
gene id: 9031:EEF2K
uniprot id: E1C172
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

9031:NRTN
gene id: 9031:NRTN
uniprot id: A0A3Q2UF79
uniprot id: A2PYM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9031:MRPS27
gene id: 9031:MRPS27
uniprot id: E1C1P9
names: Subcellular Location Annotation
messages: Mitochondrion

9031:TNNC1
gene id: 9031:TNNC1
uniprot id: P09860
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the troponin C family.
messages: Slow skeletal muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.
messages: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

9031:CDH19
gene id: 9031:CDH19
uniprot id: A6YJX3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9031:ELF1
gene id: 9031:ELF1
uniprot id: F1NXG3
uniprot id: Q5ZMG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:MMD
gene id: 9031:MMD
uniprot id: A0A1D5NZL3
uniprot id: Q5ZKB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9031:AGO4
gene id: 9031:AGO4
uniprot id: Q5ZMW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Ago subfamily.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9031:PARP16
gene id: 9031:PARP16
uniprot id: F1NBH6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9031:HACL1
gene id: 9031:HACL1
uniprot id: F1NYG7
names: Similarity
messages: Belongs to the TPP enzyme family.

9031:DLL1
gene id: 9031:DLL1
uniprot id: Q90656
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9031:OVOL3
gene id: 9031:OVOL3
uniprot id: E1BWL6
names: Subcellular Location Annotation
messages: Nucleus

9031:CACNA1D
gene id: 9031:CACNA1D
uniprot id: A0A1D5PY30
uniprot id: A0A3Q2UF34
uniprot id: A0A3Q2UHE5
uniprot id: O73700
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
messages: Expressed in the basilar papilla of the cochlea.
messages: Membrane
messages: The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
messages: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity (By similarity). Interacts with RIMBP2.
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

9031:RDH14
gene id: 9031:RDH14
uniprot id: F1N970
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:SEPTIN14
gene id: 9031:SEPTIN14
uniprot id: E1BV11
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:NT5E
gene id: 9031:NT5E
uniprot id: F1NZT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9031:C11orf49
gene id: 9031:C11orf49
uniprot id: F1P3V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

9031:COPS3
gene id: 9031:COPS3
uniprot id: Q5ZJF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN3 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the CSN complex, probably composed of COPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7, COPS8 and COPS9.
messages: Cytoplasm
messages: Nucleus

9031:PRLR
gene id: 9031:PRLR
uniprot id: Q04594
uniprot id: Q6QDA0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9031:FGFBP2
gene id: 9031:FGFBP2
uniprot id: Q802A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibroblast growth factor-binding protein family.
messages: extracellular space

9031:HRAS
gene id: 9031:HRAS
uniprot id: P08642
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

9031:PIGN
gene id: 9031:PIGN
uniprot id: A0A3Q2TS75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

9031:GPM6A
gene id: 9031:GPM6A
uniprot id: A0A3Q2UJ15
uniprot id: Q5EES3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

9031:CCR9
gene id: 9031:CCR9
uniprot id: Q702H3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:RBBP8
gene id: 9031:RBBP8
uniprot id: E1C2F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

9031:XRCC4
gene id: 9031:XRCC4
uniprot id: F1NDC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9031:CBLL1
gene id: 9031:CBLL1
uniprot id: Q5ZHZ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Hakai family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.
messages: Homodimer (By similarity). Interacts with tyrosine-phosphorylated SRC substrates (By similarity). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. Component of the MACOM subcomplex (By similarity).
messages: Nucleus speckle
messages: The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.
messages: nucleoplasm

9031:SUPT3H
gene id: 9031:SUPT3H
uniprot id: Q5ZIW0
names: Subcellular Location Annotation
messages: Nucleus

9031:ENTPD1
gene id: 9031:ENTPD1
uniprot id: A0A1D5PBT2
uniprot id: F1N851
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9031:PRORSD1P
gene id: 9031:PRORSD1P
uniprot id: A0A3Q3B0L2
names: Similarity
messages: Belongs to the PRORSD1 family.

9031:CYP1A2
gene id: 9031:CYP1A2
uniprot id: P79761
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:AQP2
gene id: 9031:AQP2
uniprot id: A7M7C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

9031:LMBRD2
gene id: 9031:LMBRD2
uniprot id: Q5F3F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: May associate with G-protein coupled receptors and regulate downstream signaling pathways.

9031:NR2F1
gene id: 9031:NR2F1
uniprot id: F1NJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:STX2
gene id: 9031:STX2
uniprot id: A0A1D5NXG4
uniprot id: A0A1D5PY18
names: Similarity
messages: Belongs to the syntaxin family.

9031:WNT3
gene id: 9031:WNT3
uniprot id: A1DYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:NTF3
gene id: 9031:NTF3
uniprot id: A0A3Q2U804
uniprot id: P25433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NGF-beta family.
messages: In the embryo, the expression peak at E4.5 and decreases at later stages of development.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

9031:DAPK3
gene id: 9031:DAPK3
uniprot id: A0A1D5PRN8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:LRRFIP2
gene id: 9031:LRRFIP2
uniprot id: A0A1D5P1C0
uniprot id: A0A3Q2TWK5
uniprot id: A0A3Q2UD46
uniprot id: A0A3Q2UIP1
uniprot id: A0A3Q3AS85
names: Similarity
messages: Belongs to the LRRFIP family.

9031:LOC771085
gene id: 9031:LOC771085
uniprot id: A0A3S5ZPJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

9031:AKR1E2
gene id: 9031:AKR1E2
uniprot id: R4GG24
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9031:PTPN13
gene id: 9031:PTPN13
uniprot id: E1C8H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9031:ATP6V0A2
gene id: 9031:ATP6V0A2
uniprot id: Q9I8C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9031:DMGDH
gene id: 9031:DMGDH
uniprot id: E1BSV1
names: Similarity
messages: Belongs to the GcvT family.

9031:DMRT1
gene id: 9031:DMRT1
uniprot id: Q0H8S8
names: Similarity
messages: Belongs to the DMRT family.

9031:TERT
gene id: 9031:TERT
uniprot id: Q537V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

9031:BAK1
gene id: 9031:BAK1
uniprot id: Q5F404
names: Similarity
messages: Belongs to the Bcl-2 family.

9031:GSKIP
gene id: 9031:GSKIP
uniprot id: Q5ZMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSKIP family.
messages: Cytoplasm

9031:FOXO1
gene id: 9031:FOXO1
uniprot id: Q9W7F9
names: Subcellular Location Annotation
messages: Nucleus

9031:AKIRIN2
gene id: 9031:AKIRIN2
uniprot id: E1C249
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9031:RPL10A
gene id: 9031:RPL10A
uniprot id: F6SU35
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

9031:PRMT7
gene id: 9031:PRMT7
uniprot id: A0A1D5NW53
uniprot id: Q5ZIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.
messages: Nucleus
messages: cytosol

9031:HPSE
gene id: 9031:HPSE
uniprot id: Q90YK5
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 79 family.
messages: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety (By similarity). Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity.
messages: Expressed, as early as 12 hours post fertilization, in cells migrating from the epiblast and forming the hypoblast layer. Later on at 72 h, preferentially expressed in cells of the developing vascular and nervous systems.
messages: Heterodimer; the active enzyme is a heterodimer of the 60 kDa and 45 kDa proteolytic products.
messages: N-glycosylated.
messages: Proteolytically cleaved to produce a 60 kDa and a 45 kDa product.
messages: Secreted

9031:PLA2G10
gene id: 9031:PLA2G10
uniprot id: D6NKG6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9031:PTCH1
gene id: 9031:PTCH1
uniprot id: A0A1D5PJW0
uniprot id: F1NYG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9031:EIF3J
gene id: 9031:EIF3J
uniprot id: Q5ZKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

9031:PGA3
gene id: 9031:PGA3
uniprot id: P16476
names: Developmental Stage
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Specifically secreted during the embryonic period in the chicken proventriculus (glandular stomach).

9031:PROK2
gene id: 9031:PROK2
uniprot id: F1NP50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9031:MAGT1
gene id: 9031:MAGT1
uniprot id: Q5ZJ06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.
messages: Accessory component of the STT3B-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.
messages: Belongs to the OST3/OST6 family.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum membrane
messages: May be involved in Mg(2+) transport in epithelial cells.

9031:CD3E
gene id: 9031:CD3E
uniprot id: P70069
names: Subcellular Location Annotation
messages: Membrane

9031:MAML2
gene id: 9031:MAML2
uniprot id: F1NYN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9031:ANXA7
gene id: 9031:ANXA7
uniprot id: E1C1D1
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9031:SKI
gene id: 9031:SKI
uniprot id: P49140
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKI family.
messages: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. May function in TGF-beta signaling (By similarity).
messages: Nucleus

9031:CDH6
gene id: 9031:CDH6
uniprot id: Q90762
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
messages: Cell membrane
messages: First expressed in splanchnic mesoderm of stage 4 embryos. At stage 6, strongly expressed along the neural fold in a region corresponding to the future neural crest. Expression in the neural fold continues during closure of the neural tube but diminishes after neural crest cells have left the neural tube.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:RAG1
gene id: 9031:RAG1
uniprot id: P24271
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination (By similarity).
messages: Homodimer. Component of the RAG complex composed of core components RAG1 and RAG2 (By similarity).
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.
messages: The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity.

9031:WNT2
gene id: 9031:WNT2
uniprot id: A0A1D5NTF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:RAB39B
gene id: 9031:RAB39B
uniprot id: A0A1D5PYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9031:PSIP1
gene id: 9031:PSIP1
uniprot id: F1NXS9
uniprot id: Q5XXA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus
messages: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).

9031:ST3GAL1
gene id: 9031:ST3GAL1
uniprot id: Q11200
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Expressed in early embryonic stages.
messages: Golgi stack membrane
messages: Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.

9031:HACD4
gene id: 9031:HACD4
uniprot id: R4GIV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:AMH
gene id: 9031:AMH
uniprot id: Q788U7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

9031:CBWD1
gene id: 9031:CBWD1
uniprot id: Q5ZK54
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

9031:FAM26D
gene id: 9031:FAM26D
uniprot id: A0A1D5PP02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9031:PSME3
gene id: 9031:PSME3
uniprot id: Q5F3J5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1 (By similarity).
messages: Belongs to the PA28 family.
messages: Homoheptamer.
messages: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity).

9031:MRPL24
gene id: 9031:MRPL24
uniprot id: A0A1D5P3Y4
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9031:CCDC53
gene id: 9031:CCDC53
uniprot id: E1BYD1
names: Similarity
messages: Belongs to the CCDC53 family.

9031:GATB
gene id: 9031:GATB
uniprot id: F1N9W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9031:SEPTIN11
gene id: 9031:SEPTIN11
uniprot id: A0A1D5PJI5
uniprot id: F1P0X3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9031:PSMD4
gene id: 9031:PSMD4
uniprot id: Q5ZI14
uniprot id: R4GLK3
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9031:DLD
gene id: 9031:DLD
uniprot id: Q5ZM32
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9031:CHAC1
gene id: 9031:CHAC1
uniprot id: R4GKI4
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9031:RAD21
gene id: 9031:RAD21
uniprot id: Q5ZLK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9031:C20orf173
gene id: 9031:C20orf173
uniprot id: A0A1D5PWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:TECRL
gene id: 9031:TECRL
uniprot id: A0A1D5P442
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

9031:STAR
gene id: 9031:STAR
uniprot id: Q9DG09
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed principally in steroidogenic tissues as ovary (granulosa from the largest preovulatory follicle and stromal tissues) and adrenals.
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).

9031:GDA
gene id: 9031:GDA
uniprot id: A0A3Q2UHG8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9031:HIC1
gene id: 9031:HIC1
uniprot id: Q90850
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
messages: Binds specifically to the gamma F-1-binding motif of the gamma F-crystallin promoter. May have a regulatory role in sclerotome specification and/or differentiation. Isoform 2 functions as a transcriptional repressor in lens cells.
messages: In the embryo of stage 11, expressed predominantly in the head mesenchyme surrounding the brain and in the paraxial mesoderm. Highly expressed in presomitic mesoderm and then over the entire epithelial somite. During somitic differentiation, expression becomes restricted to the sclerotome. In the developing lens, expression is most active at the beginning of lens fiber cell differentiation.
messages: Interacts with CtBP.
messages: Isoform 1 is highly expressed in kidney and lung. Expression of isoform 2 is higher in the lens, retina and stomach, and extremely low in heart, muscle, kidney and lung. Isoform 3 is weakly expressed in heart, kidney and lens.
messages: Nucleus

9031:NME3
gene id: 9031:NME3
uniprot id: R4GM98
names: Similarity
messages: Belongs to the NDK family.

9031:PCNA
gene id: 9031:PCNA
uniprot id: Q9DEA3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with DNMT1 (By similarity). Interacts with CHAF1A. Component of the replisome complex (By similarity).
messages: Monoubiquitinated by the UBE2B-RAD18 complex on Lys-164. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis (By similarity).
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

9031:PDE4D
gene id: 9031:PDE4D
uniprot id: A0A1D5NZI1
uniprot id: A0A1D5PP20
uniprot id: F1NB56
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:SLC47A2
gene id: 9031:SLC47A2
uniprot id: E1BR23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

9031:THNSL2
gene id: 9031:THNSL2
uniprot id: A0A1L1RJ01
names: Similarity
messages: Belongs to the threonine synthase family.

9031:KLC2
gene id: 9031:KLC2
uniprot id: A0A3Q3AI12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9031:LOC100858797
gene id: 9031:LOC100858797
uniprot id: R4GLQ9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:TMEM129
gene id: 9031:TMEM129
uniprot id: Q5ZI25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

9031:SBDS
gene id: 9031:SBDS
uniprot id: Q5ZIY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the 60S ribosomal subunit.
messages: Belongs to the SDO1/SBDS family.
messages: Cytoplasm
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).
messages: nucleolus
messages: nucleoplasm
messages: spindle

9031:CSTF2
gene id: 9031:CSTF2
uniprot id: A0A3Q2UCR0
uniprot id: Q5ZLS0
names: Subcellular Location Annotation
messages: Nucleus

9031:CHD2
gene id: 9031:CHD2
uniprot id: A0A1D5PMQ3
names: Subcellular Location Annotation
messages: Nucleus

9031:ARL2BP
gene id: 9031:ARL2BP
uniprot id: Q5ZKW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL2BP family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Nucleus
messages: Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.
messages: centrosome
messages: cilium basal body
messages: spindle

9031:PSEN1
gene id: 9031:PSEN1
uniprot id: A0A3Q2UE42
uniprot id: Q4JIM4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
messages: Cell membrane
messages: Cytoplasmic granule
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by a caspase.
messages: Homodimer.
messages: Homodimer. The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity (By similarity). Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment (By similarity). Interacts with CDH2 (PubMed:16046145).
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Substrates, such as NOTCH1 and APP peptides, are bound between PSEN1 transmembrane domains and via the first lumenal loop and the cytoplasmic loop between the sixth and seventh transmembrane domains. Substrate binding causes a conformation change and formation of an intermolecular antiparallel beta-sheet between PSEN1 and its substrates.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

9031:TIMM10
gene id: 9031:TIMM10
uniprot id: E1BXY8
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

9031:FGF6
gene id: 9031:FGF6
uniprot id: F1P5Y5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:PKNOX2
gene id: 9031:PKNOX2
uniprot id: Q8AYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9031:MYF6
gene id: 9031:MYF6
uniprot id: C4P6Q1
uniprot id: Q01795
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
messages: Nucleus
messages: Skeletal muscle.

9031:ADSS1
gene id: 9031:ADSS1
uniprot id: F1NVD4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9031:HOXB5
gene id: 9031:HOXB5
uniprot id: Q5I188
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9031:PA2G4
gene id: 9031:PA2G4
uniprot id: A0A1D5P7C6
names: Similarity
messages: Belongs to the peptidase M24 family.

9031:TIMP4
gene id: 9031:TIMP4
uniprot id: A0A1D5NY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

9031:TAF13
gene id: 9031:TAF13
uniprot id: Q5ZLI0
names: Subcellular Location Annotation
messages: Nucleus

9031:FAM135A
gene id: 9031:FAM135A
uniprot id: A0A1D5PV38
uniprot id: F1P508
names: Similarity
messages: Belongs to the FAM135 family.

9031:UBE2U
gene id: 9031:UBE2U
uniprot id: R4GJY8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:HIST1H2B7L4
gene id: 9031:HIST1H2B7L4
uniprot id: P0C1H3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct.
messages: Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:CCNJ
gene id: 9031:CCNJ
uniprot id: E1C1A2
names: Similarity
messages: Belongs to the cyclin family.

9031:DPF3
gene id: 9031:DPF3
uniprot id: A0A452J871
uniprot id: P58270
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the requiem/DPF family.
messages: Component of the BAF complex. Interacts with acetylated histones H3 and H4. Component of neuron-specific chromatin remodeling complex (nBAF complex), a subfamily of ATP-dependent SWI/SNF chromatin remodeling complexes (By similarity).
messages: Expressed in the heart and somites.
messages: Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in neural development.
messages: Nucleus
messages: The PHD-type zinc fingers mediate the binding to acetylated histones.

9031:SCAMP2
gene id: 9031:SCAMP2
uniprot id: F1NV32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9031:SFRP5
gene id: 9031:SFRP5
uniprot id: A0A0K0PVD8
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:IKZF1
gene id: 9031:IKZF1
uniprot id: O42410
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity).
messages: Expressed early in embryo from embryonic day 2 onwards.
messages: Expressed in embryonic hematopoietic organs such as the bursa of Fabricius, thymus and spleen. In the adult, expressed in spleen, thymus, bursa and peripheral blood leukocytes.
messages: Nucleus

9031:TEKT3
gene id: 9031:TEKT3
uniprot id: E1BZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

9031:NR4A2
gene id: 9031:NR4A2
uniprot id: A0A1D5NYR5
uniprot id: E1C6K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Nucleus

9031:ERGIC3
gene id: 9031:ERGIC3
uniprot id: A0A1D5P4J2
uniprot id: R4GJ83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9031:LOC420294
gene id: 9031:LOC420294
uniprot id: A0A1D5Q028
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

9031:PSMB5
gene id: 9031:PSMB5
uniprot id: P34065
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Directly interacts with POMP. Interacts with ABCB1 and TAP1.

9031:KCNN3
gene id: 9031:KCNN3
uniprot id: A0A1D5NU20
names: Subcellular Location Annotation
messages: Membrane

9031:GRB14
gene id: 9031:GRB14
uniprot id: A0A1D5NTQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9031:ACOX3
gene id: 9031:ACOX3
uniprot id: E1C1E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9031:TRAPPC4
gene id: 9031:TRAPPC4
uniprot id: Q5ZHS6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9031:EIF4A2
gene id: 9031:EIF4A2
uniprot id: Q8JFP1
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIFFG3 (By similarity). Interacts with EIF4E (By similarity).

9031:B4GALT2
gene id: 9031:B4GALT2
uniprot id: Q92073
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:XDH
gene id: 9031:XDH
uniprot id: P47990
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters per subunit.
messages: Cytoplasm
messages: Detected in liver (at protein level).
messages: Homodimer.
messages: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
messages: Peroxisome

9031:RGS3
gene id: 9031:RGS3
uniprot id: Q7SYH9
names: Subcellular Location Annotation
messages: Cytoplasm

9031:GJA10
gene id: 9031:GJA10
uniprot id: E1BZR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:PPIL3
gene id: 9031:PPIL3
uniprot id: Q5ZLV2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9031:FFAR2L7
gene id: 9031:FFAR2L7
uniprot id: A0A0C4WTK8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:ATG101
gene id: 9031:ATG101
uniprot id: A0A1L1S0P7
names: Similarity
messages: Belongs to the ATG101 family.

9031:CARS
gene id: 9031:CARS
uniprot id: Q5F408
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
messages: Cytoplasm
messages: Homodimer.

9031:AvBD1
gene id: 9031:AvBD1
uniprot id: P46156
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Detected in the theca layer of the ovarian follicle in the white follicle (WF) stage, but decreases throughout the F1, F3, F5, and postovulatory follicle stages. Detected in the granulosa layer of the ovarian follicle in the white follicle (WF) stage, F1, F3, F5, and postovulatory follicle stages. In the vagina expression is higher in laying hens than in non-laying hens, and is higher in older laying hens than in young laying hens.
messages: Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans.
messages: Induced in the theca layer of the F3 stage ovarian follicle by intravenous injection of LPS. Repressed in the granulosa layer of the F3 stage ovarian follicle by intravenous injection of LPS. Expression in cultured vaginal cells is increased by LPS and S.enteritidis. Expression in the kidney and liver is not affected by intravenous injection of LPS.
messages: Secreted
messages: Strong expression in the bone marrow, lung, testis. Moderate expression in the bursa and intestine. Low expression in the cloaca, gall bladder, brain and pancreas. Expressed in the vagina, ovarian stroma and the theca and granulosa layers of the ovarian follicle.

9031:UBE2H
gene id: 9031:UBE2H
uniprot id: Q5ZLI7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9031:TNK2
gene id: 9031:TNK2
uniprot id: R4GK19
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9031:EPHA7
gene id: 9031:EPHA7
uniprot id: O42422
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Cell membrane
messages: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
messages: Phosphorylated.
messages: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7 (By similarity).
messages: Within the nervous system, expression is restricted to prosomeres 1 and 2 in the diencephalon and all the rhombomeres in the hindbrain during segmentation stages. Later on, a superimposed pattern appears that correlates with the formation of several axonal tracts. In the somitic mesoderm, the expression correlates with segmentation and the guidance of both neural crest and motor axons through the sclerotomes.

9031:EMX1
gene id: 9031:EMX1
uniprot id: A0A1D5PI40
names: Subcellular Location Annotation
messages: Nucleus

9031:AP1S3
gene id: 9031:AP1S3
uniprot id: A0A3Q3APK7
uniprot id: E1BWN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

9031:WNT1
gene id: 9031:WNT1
uniprot id: Q91029
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A palmitoylation site was proposed at Cys-91, but it was later shown that this cysteine is engaged in a disulfide bond.
messages: Belongs to the Wnt family.
messages: Expression in the met-mesencephalic region.
messages: Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids (By similarity). Interacts with PORCN (PubMed:25451226).
messages: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:25451226). Developmental protein that promotes cell proliferation in the developing spinal cord (PubMed:25451226). Has a role in osteoblast function, bone development and bone homeostasis (By similarity).
messages: N-glycosylated. N-glycosylation favors subsequent palmitoleoylation.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Palmitoleoylation is necessary for proper trafficking to cell surface (Probable). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).
messages: Secreted
messages: extracellular matrix

9031:KCNG2
gene id: 9031:KCNG2
uniprot id: O73606
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.
messages: Heterodimer with KCNB1. Does not form homomultimers (By similarity).
messages: Membrane
messages: Potassium channel subunit. Modulates channel activity (By similarity).
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

9031:NMBR
gene id: 9031:NMBR
uniprot id: E1BRP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:TEK
gene id: 9031:TEK
uniprot id: A0A3Q2UKD3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SPIN1L
gene id: 9031:SPIN1L
uniprot id: Q90WG2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SPIN/STSY family.
messages: Expressed in early embryo.
messages: Expressed predominantly in ovarian granulosa and thecal cell.
messages: May play a role in mitosis.
messages: Nucleus

9031:APRT
gene id: 9031:APRT
uniprot id: A0A1D5NUK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

9031:MYH1G
gene id: 9031:MYH1G
uniprot id: Q8JG72
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:PNO1
gene id: 9031:PNO1
uniprot id: Q5F414
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNO1 family.
messages: Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
messages: nucleolus

9031:CD34
gene id: 9031:CD34
uniprot id: E1BUT3
names: Subcellular Location Annotation
messages: Membrane

9031:SCN8A
gene id: 9031:SCN8A
uniprot id: A0A1D5PBH0
uniprot id: A0A1D5PQT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

9031:PPP2R5E
gene id: 9031:PPP2R5E
uniprot id: F1NLM6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

9031:TRAP1
gene id: 9031:TRAP1
uniprot id: Q5ZMF6
names: Similarity
messages: Belongs to the heat shock protein 90 family.

9031:CORO2B
gene id: 9031:CORO2B
uniprot id: A0A1D5PVL9
uniprot id: A0A3Q3AYV8
uniprot id: E1C2B6
names: Similarity
messages: Belongs to the WD repeat coronin family.

9031:HPD
gene id: 9031:HPD
uniprot id: F1NVJ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9031:RBPJ
gene id: 9031:RBPJ
uniprot id: A0A3Q2UCS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9031:SRC
gene id: 9031:SRC
uniprot id: P00523
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Becomes activated when its major tyrosine phosphorylation site is not phosphorylated. It can also be activated by point mutations as well as by truncations at the C-terminal end or by other mutations. Heme regulates its activity by enhancing the phosphorylation on Tyr-527 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Dephosphorylated at Tyr-527 by PTPRJ. Phosphorylated on Tyr-527 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-416. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-527, the SH3 domain engaged with the SH2-kinase linker, and Tyr-416 dephosphorylated. Dephosphorylation of Tyr-527 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-527, Tyr-416 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-527 by CSK allows this interaction to reform, resulting in SRC inactivation (By similarity).
messages: Endosome membrane
messages: Expressed to high levels, and with a high degree of kinase activity, in certain fully differentiated cells such as neurons, platelets and macrophages. Isoform 1 is widely expressed. Isoform 2 is expressed only in the muscle.
messages: Forms a complex with polyoma virus middle T antigen. Interacts with AFAP-110. Interacts with GJA1 and PXN.
messages: Membrane-bound.
messages: Mitochondrion inner membrane
messages: Myristoylated at Gly-2, and this is essential for targeting to membranes.
messages: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (By similarity). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:1717492, PubMed:8550628). Involved in anchorage-independent cell growth (PubMed:19307596).
messages: Nucleus
messages: S-nitrosylation is important for activation of its kinase activity.
messages: cytoskeleton
messages: focal adhesion
messages: perinuclear region

9031:PARN
gene id: 9031:PARN
uniprot id: Q5ZJ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm
messages: Nucleus

9031:XPO5
gene id: 9031:XPO5
uniprot id: A0A1D5PSL9
uniprot id: F1NBL6
names: Subcellular Location Annotation
messages: Cytoplasm

9031:SLC7A1
gene id: 9031:SLC7A1
uniprot id: C0IN11
uniprot id: F1P388
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9031:MFSD2A
gene id: 9031:MFSD2A
uniprot id: F1NCD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (By similarity). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity).

9031:GABRR2
gene id: 9031:GABRR2
uniprot id: F1ND90
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9031:FLI1
gene id: 9031:FLI1
uniprot id: Q5ZKX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9031:CTNNA1
gene id: 9031:CTNNA1
uniprot id: E1C7M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: cytoskeleton

9031:CDK7
gene id: 9031:CDK7
uniprot id: E1C8L2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9031:NCBP1
gene id: 9031:NCBP1
uniprot id: Q5ZJZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NCBP1 family.
messages: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. The conventional CBC with NCBP2 binds both small nucle…
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA. Component of an alternative nuclear cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3 (By similarity).
messages: Cytoplasm
messages: Nucleus

9031:OSBPL9
gene id: 9031:OSBPL9
uniprot id: A0A3Q2U913
names: Similarity
messages: Belongs to the OSBP family.

9031:NDOR1
gene id: 9031:NDOR1
uniprot id: E1BY65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.
messages: perinuclear region

9031:ATP5F1AW
gene id: 9031:ATP5F1AW
uniprot id: A0A1L1RZJ6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9031:GHRHR-LR
gene id: 9031:GHRHR-LR
uniprot id: B3F053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9031:FAM129B
gene id: 9031:FAM129B
uniprot id: F1NZE1
names: Similarity
messages: Belongs to the Niban family.

9031:HMGB2
gene id: 9031:HMGB2
uniprot id: P26584
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome
messages: Cytoplasm
messages: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA (PubMed:14672558). Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity).
messages: Nucleus
messages: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).
messages: Secreted

9031:PPRC1
gene id: 9031:PPRC1
uniprot id: F1N955
names: Subcellular Location Annotation
messages: Nucleus

9031:CCT2
gene id: 9031:CCT2
uniprot id: Q5F424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9031:NRN1L
gene id: 9031:NRN1L
uniprot id: A0A3Q3AUX4
names: Similarity
messages: Belongs to the neuritin family.

9031:C12orf75
gene id: 9031:C12orf75
uniprot id: P0C915
names: Similarity
messages: Belongs to the OCC1 family.

9031:NQO2
gene id: 9031:NQO2
uniprot id: R4GLI9
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9031:RHBDD1
gene id: 9031:RHBDD1
uniprot id: E1BT32
names: Subcellular Location Annotation
messages: Membrane

9031:FGF7
gene id: 9031:FGF7
uniprot id: Q5KRA4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:TNFRSF10B
gene id: 9031:TNFRSF10B
uniprot id: Q9IAR7
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

9031:GREM1
gene id: 9031:GREM1
uniprot id: O73755
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling.
messages: In brain first detected at 6 dpc and persisted until 14 dpc. On 10 dpc brain, expressed in the dorsal region of the telencephalic hemispheres and cells located in the ventral diencephalon. On 14 dpc head, expressed in the meninges of the spinal cord. Expressed in the developing optic nerve and at the optic nerve/pecten junction.
messages: Secreted

9031:SLC45A2
gene id: 9031:SLC45A2
uniprot id: F1NJ93
names: Subcellular Location Annotation
messages: Membrane

9031:SOX9
gene id: 9031:SOX9
uniprot id: P48434
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: By BMP2 during chondrogenesis.
messages: Found in chondrogenic regions in the branchial arches, somites and limb buds at 22 dpc. At 28 dpc detected in the limbs, developing scapula, prevertebrae and ribs. Found in condensing mesenchyme of the forelimb at 25 dpc. Expressed in the condensing mesenchyme at the distal tips of the developing hindlimbs at 26 dpc.
messages: Interacts with SNAI2; triggers neural crest delamination in a phosphorylation dependent manner. Interacts with UBE2I.
messages: Nucleus
messages: Phosphorylated at Ser-181 in the developing neural tube. Phosphorylation at either Ser-64 or Ser-181 is required for sumoylation, but phosphorylation is not dependent on sumoylation. Sumoylation is enhanced by PKA. Phosphorylation is required for interaction with SNAI2 to trigger neural crest delamination and for an efficient trunk neural crest delamination, whereas sumoylation plays a less significant role. Phosphorylation and sumoylation are induced by BMP signaling pathway.
messages: Sumoylated at Lys-376; phosphorylation at either Ser-64 or Ser-181 is required for sumoylation. Sumoylation is induced by BMP signaling pathway.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:10340758, PubMed:9858536). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1 (PubMed:10340758, PubMed:9858536). Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells (By similarity). In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination (PubMed:23382206).

9031:LOC771308
gene id: 9031:LOC771308
uniprot id: A6YIJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9031:JAK1
gene id: 9031:JAK1
uniprot id: F1NMJ9
uniprot id: Q9PWM9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9031:DLX6
gene id: 9031:DLX6
uniprot id: F1NCY8
uniprot id: Q6DV99
names: Subcellular Location Annotation
messages: Nucleus

9031:MSLNL
gene id: 9031:MSLNL
uniprot id: A0A3Q2UBZ4
names: Similarity
messages: Belongs to the mesothelin family.

9031:HSF4
gene id: 9031:HSF4
uniprot id: D0VYS4
uniprot id: F1NNK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9031:LAMP5
gene id: 9031:LAMP5
uniprot id: A0A0B4J1C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

9031:GLUL
gene id: 9031:GLUL
uniprot id: P16580
names: Activity Regulation
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Expressed in retina, brain and liver (PubMed:1356223). Little or no detectable expression in breast muscle, pancreas and spleen (PubMed:1356223).
messages: Glutamate to glutamine ratio influences catalytic activity (PubMed:19895308). At glutamate to glutamine ratios greater than 4, decarboxylase activity ceases (PubMed:19895308). In the presence of manganese, synthetase activity is limited to concentrations between 10 mM and 20 mM, whereas decarboxylase activity is not affected (PubMed:19895308). Both catalytic activities are inhibited by avidin (PubMed:19895308).
messages: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:19895308). When expressed in liver, it may be involved in detoxifying intramitochondrially generated ammonia (PubMed:4401992). Also acts as glutamate decarboxylase by catalyzing the production of 4-aminobutanoate (gamma-aminobutyric acid, GABA) in a pyridoxal phosphate-independent manner (PubMed:19895308).
messages: Homooctamer and homotetramer.
messages: In the retina, down-regulated upon application of glutamate concentrations of 15 umol/eye or higher.
messages: Mitochondrion
messages: Weakly expressed in retina on embryonic day 18, with levels increasing until day 6 after hatching and then remaining high until day 21 (at protein level).

9031:ASXL2
gene id: 9031:ASXL2
uniprot id: A0A3Q2UB41
uniprot id: Q5ZM88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors.
messages: Nucleus
messages: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (By similarity).

9031:CRYBB1
gene id: 9031:CRYBB1
uniprot id: P07530
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).

9031:RC3H2
gene id: 9031:RC3H2
uniprot id: F1NZ02
names: Subcellular Location Annotation
messages: P-body

9031:DAZL
gene id: 9031:DAZL
uniprot id: Q804A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM DAZ family.
messages: Cytoplasm
messages: RNA-binding protein, which probably plays a central role in gametogenesis in both males and females. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and promoting the translation of key transcripts (By similarity).

9031:PLLP
gene id: 9031:PLLP
uniprot id: Q5ZIE5
names: Subcellular Location Annotation
messages: Membrane

9031:STX12
gene id: 9031:STX12
uniprot id: E1C319
names: Similarity
messages: Belongs to the syntaxin family.

9031:ARSB
gene id: 9031:ARSB
uniprot id: F1P099
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:THOP1
gene id: 9031:THOP1
uniprot id: A0A1D5PIZ1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9031:ATP6V0E2
gene id: 9031:ATP6V0E2
uniprot id: F1P345
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9031:GSTA3
gene id: 9031:GSTA3
uniprot id: Q08392
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Alpha family.
messages: Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid.
messages: Homodimer or heterodimer of GSTA1 and GSTA2.

9031:TBX18
gene id: 9031:TBX18
uniprot id: Q68SB0
uniprot id: Q7T2Z6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:HIST1H3H
gene id: 9031:HIST1H3H
uniprot id: P84229
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by RAG1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HMGB1.

9031:RAD54L2
gene id: 9031:RAD54L2
uniprot id: A0A1D5PDU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9031:CAV1
gene id: 9031:CAV1
uniprot id: P35431
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).
messages: Membrane raft
messages: Phosphorylated on tyrosine residue(s).
messages: caveola

9031:BTN1A1
gene id: 9031:BTN1A1
uniprot id: Q49K83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

9031:SMIM18
gene id: 9031:SMIM18
uniprot id: A0A3Q2TZK5
names: Subcellular Location Annotation
messages: Membrane

9031:MGA
gene id: 9031:MGA
uniprot id: A0A3Q2TWM7
uniprot id: A0A3Q2U217
uniprot id: A0A3Q2UMQ7
uniprot id: A0A3Q3B130
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:NT5DC3
gene id: 9031:NT5DC3
uniprot id: A0A1D5PNR2
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

9031:ADAMTS17
gene id: 9031:ADAMTS17
uniprot id: A0A1D5NUB9
uniprot id: A0A1D5P6Z0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:CDC45
gene id: 9031:CDC45
uniprot id: A0A3Q2UBE9
uniprot id: E1BYS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

9031:CCDC58
gene id: 9031:CCDC58
uniprot id: A0A1L1RWZ8
names: Similarity
messages: Belongs to the MIX23 family.

9031:TMEM258
gene id: 9031:TMEM258
uniprot id: Q76LT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9031:SULT
gene id: 9031:SULT
uniprot id: O57338
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:KHDC4
gene id: 9031:KHDC4
uniprot id: Q5ZL54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KHDC4 family.
messages: Cytoplasm
messages: Interacts with PRPF19.
messages: Nucleus
messages: RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
messages: The C-terminal part is necessary for the interaction with the PRP19C/Prp19 complex/NTC/Nineteen complex.
messages: The KH domains mediate RNA-binding.

9031:TGS1
gene id: 9031:TGS1
uniprot id: Q5ZJ77
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

9031:AASDHPPT
gene id: 9031:AASDHPPT
uniprot id: R4GI82
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9031:CFAP52
gene id: 9031:CFAP52
uniprot id: E1BQP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: Cytoplasm
messages: flagellum

9031:LDHB
gene id: 9031:LDHB
uniprot id: P00337
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer.
messages: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).

9031:LYRM7
gene id: 9031:LYRM7
uniprot id: A0A1D5PQS9
uniprot id: A0A3Q2UAX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

9031:LSM6
gene id: 9031:LSM6
uniprot id: E1C8T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9031:FARSB
gene id: 9031:FARSB
uniprot id: Q5ZJ61
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9031:HIBCH
gene id: 9031:HIBCH
uniprot id: A0A1D5NTK1
uniprot id: Q5ZJ60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity).
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9031:PAX3
gene id: 9031:PAX3
uniprot id: Q8QGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9031:GCGR
gene id: 9031:GCGR
uniprot id: A6N8N7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:MBOAT1
gene id: 9031:MBOAT1
uniprot id: Q5ZKE9
names: Subcellular Location Annotation
messages: Membrane

9031:PIGF
gene id: 9031:PIGF
uniprot id: E1C2L3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:SLC12A7
gene id: 9031:SLC12A7
uniprot id: A0A1D5P9V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9031:TNR
gene id: 9031:TNR
uniprot id: Q00546
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tenascin family.
messages: Brain specific.
messages: Expression weakly detectable at 6 dpc embryo, reaches a maximum at 16 dpc and declines in the adult.
messages: Forms homodimers and homotrimers. Interacts with CNTN1, NFASC and CSPG5.
messages: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Involved in cell attachment and neurite formation. Interaction with CNTN1 enhances the neurite outgrowth.
messages: The N-terminus cysteine-rich segment may mediate the formation of oligomers. The fibronectin type-III 2-3 mediate the binding to contactin 1. The fibronectin type-III 9 mediates the cell attachment. The fibronectin type-III 2-5 mediate NFASC binding. The fibrinogen C-terminal domain mediates interaction with CSPG5.
messages: extracellular matrix

9031:LY6E
gene id: 9031:LY6E
uniprot id: Q90986
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Expressed by thymic blast cells.

9031:TIPRL
gene id: 9031:TIPRL
uniprot id: F1NR86
names: Similarity
messages: Belongs to the TIP41 family.

9031:VWA9
gene id: 9031:VWA9
uniprot id: Q5ZK21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9031:ALDH3B2
gene id: 9031:ALDH3B2
uniprot id: A0A1D5P553
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9031:DHCR7
gene id: 9031:DHCR7
uniprot id: F1P4X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9031:APOV1
gene id: 9031:APOV1
uniprot id: P02659
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: ApoII mRNA induction by estrogen in kidney at day 11 is at 10% of the level in the liver but estrogen-responsiveness decreases later in development and is low in the adult.
messages: Belongs to the apovitellenin family.
messages: By steroids (estrogen).
messages: Homodimer; disulfide-linked.
messages: Produced by the liver, secreted into the blood and then sequestred by receptor mediated endocytosis into growing oocytes.
messages: Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes.

9031:MTMR8
gene id: 9031:MTMR8
uniprot id: Q5F452
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Nucleus envelope
messages: Phosphatase that acts on lipids with a phosphoinositol headgroup (By similarity). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).

9031:ARL6IP5
gene id: 9031:ARL6IP5
uniprot id: Q5F433
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA1 family.
messages: Binds to prenylated RAB and Ras superfamily members.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic.
messages: cytoskeleton

9031:DBR1
gene id: 9031:DBR1
uniprot id: Q5ZLM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function.
messages: Nucleus

9031:PSPC1
gene id: 9031:PSPC1
uniprot id: Q5ZK88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PSPC family.
messages: Cytoplasm
messages: Nucleus matrix
messages: Nucleus speckle
messages: Together with NONO, required for the formation of nuclear paraspeckles. Acts as a coactivator during transcriptional activation. Binds to RNA. May act as a regulator the circadian clock (By similarity).
messages: nucleolus

9031:EIF2S3
gene id: 9031:EIF2S3
uniprot id: Q5ZMS3
names: Function
names: Similarity
names: Subunit
messages: As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: The eukaryotic translation initiation factor 2 complex/eIF2 is a heterotrimer composed of an alpha, a beta and a gamma subunit.

9031:PRDM15
gene id: 9031:PRDM15
uniprot id: A0A3Q2UBY3
uniprot id: E1BZC6
names: Subcellular Location Annotation
messages: Nucleus

9031:SPIN1
gene id: 9031:SPIN1
uniprot id: Q90WG1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SPIN/STSY family.
messages: Expressed in early embryo.
messages: Expressed in several tissues including testis.
messages: May play a role in mitosis.
messages: Nucleus

9031:TBXAS1
gene id: 9031:TBXAS1
uniprot id: A0A3Q3APH5
uniprot id: F1P4G4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:LAMTOR1
gene id: 9031:LAMTOR1
uniprot id: A0A3Q2TWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

9031:SLC7A3
gene id: 9031:SLC7A3
uniprot id: A0A1D5PY78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9031:PEX1
gene id: 9031:PEX1
uniprot id: E1BY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

9031:SNRPN
gene id: 9031:SNRPN
uniprot id: Q9PV94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP SmB/SmN family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (By similarity). Component of the U1 snRNP (By similarity). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (By similarity). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (By similarity). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (By similarity). Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts with TDRD3 and SNUPN (By similarity). Interacts with PRMT5; interaction lead…
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
messages: cytosol

9031:TIMM44
gene id: 9031:TIMM44
uniprot id: F1NU71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

9031:SPERT
gene id: 9031:SPERT
uniprot id: A1KXM5
names: Similarity
messages: Belongs to the chibby family. SPERT subfamily.

9031:PBRM1
gene id: 9031:PBRM1
uniprot id: A0A1D5PJG5
uniprot id: A0A3Q2UJ59
uniprot id: Q90941
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex.
messages: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).
messages: Nucleus

9031:RPS24
gene id: 9031:RPS24
uniprot id: F1NF89
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9031:APOO
gene id: 9031:APOO
uniprot id: A0A1D5NXD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9031:CPPED1
gene id: 9031:CPPED1
uniprot id: A0A1D5PJC6
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.

9031:NRG2
gene id: 9031:NRG2
uniprot id: A0A1D5PVP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:LIPT1
gene id: 9031:LIPT1
uniprot id: E1BVP4
names: Similarity
messages: Belongs to the LplA family.

9031:MFN1
gene id: 9031:MFN1
uniprot id: Q5ZKH5
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9031:KMT5A
gene id: 9031:KMT5A
uniprot id: A0A3Q2U747
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9031:CPE
gene id: 9031:CPE
uniprot id: R4GFJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Membrane
messages: secretory vesicle membrane

9031:GRM8
gene id: 9031:GRM8
uniprot id: A0A1D5PGF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9031:METAP2
gene id: 9031:METAP2
uniprot id: Q5ZIL5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

9031:KRT5
gene id: 9031:KRT5
uniprot id: Q6PVZ5
names: Similarity
messages: Belongs to the intermediate filament family.

9031:FOXA1
gene id: 9031:FOXA1
uniprot id: A0A1D5PCB1
names: Subcellular Location Annotation
messages: Nucleus

9031:RLN3
gene id: 9031:RLN3
uniprot id: B1AC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9031:ENPP6
gene id: 9031:ENPP6
uniprot id: A0A3Q2TVC4
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

9031:CGA
gene id: 9031:CGA
uniprot id: F1NJD3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer of an alpha and a beta chain.
messages: Secreted

9031:FREM2
gene id: 9031:FREM2
uniprot id: A0A1D5PEU2
names: Similarity
messages: Belongs to the FRAS1 family.

9031:SLC16A14
gene id: 9031:SLC16A14
uniprot id: E1C1Q8
names: Subcellular Location Annotation
messages: Membrane

9031:WAPL
gene id: 9031:WAPL
uniprot id: F1NF28
names: Similarity
messages: Belongs to the WAPL family.

9031:AHCYL2
gene id: 9031:AHCYL2
uniprot id: A0A1D5PF77
uniprot id: A0A1L1S0T2
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9031:DARS
gene id: 9031:DARS
uniprot id: Q5ZJQ5
uniprot id: Q5ZJQ6
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

9031:KCND2
gene id: 9031:KCND2
uniprot id: E1BS72
uniprot id: Q8UW33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

9031:ANGPTL4
gene id: 9031:ANGPTL4
uniprot id: F1NUQ4
names: Subcellular Location Annotation
messages: Secreted

9031:RICTOR
gene id: 9031:RICTOR
uniprot id: F1NMJ6
names: Similarity
messages: Belongs to the RICTOR family.

9031:LANCL1
gene id: 9031:LANCL1
uniprot id: A0A1D5PYA4
names: Similarity
messages: Belongs to the LanC-like protein family.

9031:VEGFD
gene id: 9031:VEGFD
uniprot id: A0A1L1RNL9
uniprot id: F1NHR2
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9031:LOC770940
gene id: 9031:LOC770940
uniprot id: A0A3Q2TVE1
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:RHOC
gene id: 9031:RHOC
uniprot id: Q9PSX7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Cleavage furrow
messages: Detected in embryonic notochord.
messages: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity).

9031:CENPJ
gene id: 9031:CENPJ
uniprot id: E1C0R8
names: Similarity
messages: Belongs to the TCP10 family.

9031:MKI67
gene id: 9031:MKI67
uniprot id: R4GLV4
names: Subcellular Location Annotation
messages: Nucleus

9031:STON1
gene id: 9031:STON1
uniprot id: E1BRM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm

9031:SUFU
gene id: 9031:SUFU
uniprot id: Q8QG94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Nucleus

9031:LOC776816
gene id: 9031:LOC776816
uniprot id: Q5ZMQ2
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3.
messages: Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:ABHD2
gene id: 9031:ABHD2
uniprot id: F1P1V6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9031:PPIP5K1
gene id: 9031:PPIP5K1
uniprot id: A0A1D5P3Z0
uniprot id: A0A3Q2TWW6
uniprot id: A0A3Q2TXA8
uniprot id: A0A3Q2U812
uniprot id: A0A3Q2UDD9
uniprot id: E1BXR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9031:KIF13A
gene id: 9031:KIF13A
uniprot id: F1P140
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:LAMA5
gene id: 9031:LAMA5
uniprot id: A0A3Q2UJC9
uniprot id: F1NZZ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

9031:RAP1GAP2
gene id: 9031:RAP1GAP2
uniprot id: Q5ZMV8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

9031:PTH
gene id: 9031:PTH
uniprot id: A9YX65
uniprot id: P15743
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
messages: Secreted

9031:ADGRB3
gene id: 9031:ADGRB3
uniprot id: A0A3Q2TVT9
uniprot id: A0A3Q2UBW1
uniprot id: A0A3Q2UE52
uniprot id: E1BZ18
names: Subcellular Location Annotation
messages: Membrane

9031:SERPINB12
gene id: 9031:SERPINB12
uniprot id: E1BTF2
names: Similarity
messages: Belongs to the serpin family.

9031:ESRP1
gene id: 9031:ESRP1
uniprot id: A0A1D5P7J2
uniprot id: A0A1J0PJB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

9031:MAF
gene id: 9031:MAF
uniprot id: Q789F3
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE).
messages: Belongs to the bZIP family. Maf subfamily.
messages: Expressed in kidney, brain, lung, gut, mesenterium, testis and ovary.
messages: Expressed in the lens placode at stage 14. Expressed at stage 18 when the invaginating lens placode closes to form the lens vesicle.
messages: Homodimer or heterodimer. Binds DNA as a homodimer or a heterodimer. Interacts with HOXD12, PAX6 and PRRX1; interaction is direct and inhibits its DNA-binding and transactivating activity.
messages: Nucleus
messages: The basic region and the leucine zipper structure are necessary for association with HOXD12 and PRRX1.

9031:FAM18B1
gene id: 9031:FAM18B1
uniprot id: Q5ZJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

9031:PCSK2
gene id: 9031:PCSK2
uniprot id: A0A3Q2TYP3
names: Similarity
messages: Belongs to the peptidase S8 family.

9031:C4BPG
gene id: 9031:C4BPG
uniprot id: Q4AEI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:CCL20
gene id: 9031:CCL20
uniprot id: Q8QG55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:CA8
gene id: 9031:CA8
uniprot id: A0A1D5PPM5
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9031:CHD7
gene id: 9031:CHD7
uniprot id: Q06A37
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Expressed in the neural epithelium, otic placodes, optic placodes, branchial arches, and the olfactory placodes,.
messages: Expression is pan-neuronal at stages 8-20. Expressed throughout the rostral neural ectoderm and along the rostrocaudal axis but is absent from the more lateral, non-neuronal ectoderm. Adjacent to the neural tube, detected at the optic and otic placodes. At stage 20, expression is observed in the branchial arches and olfactory placodes in addition to brain and optic and otic placodes.
messages: Nucleus
messages: Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity).

9031:HMBOX1
gene id: 9031:HMBOX1
uniprot id: E1BZ53
names: Subcellular Location Annotation
messages: Nucleus

9031:CYP11A1
gene id: 9031:CYP11A1
uniprot id: O13254
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion inner membrane

9031:LOC107055264
gene id: 9031:LOC107055264
uniprot id: A0A1L1RZV5
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:SH3YL1
gene id: 9031:SH3YL1
uniprot id: F1NNR2
names: Similarity
messages: Belongs to the SH3YL1 family.

9031:SLC5A7
gene id: 9031:SLC5A7
uniprot id: F1P4Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9031:RNPS1
gene id: 9031:RNPS1
uniprot id: E1BV45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus speckle

9031:MRPS26
gene id: 9031:MRPS26
uniprot id: Q2ACD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

9031:LOC100859848
gene id: 9031:LOC100859848
uniprot id: A0A3Q2U818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9031:SLAIN2
gene id: 9031:SLAIN2
uniprot id: A0A3Q2U2B3
uniprot id: F1NZZ4
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9031:PRCP
gene id: 9031:PRCP
uniprot id: A0A1D5PVG8
names: Similarity
messages: Belongs to the peptidase S28 family.

9031:LCMT1
gene id: 9031:LCMT1
uniprot id: Q5ZII2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9031:MPPED1
gene id: 9031:MPPED1
uniprot id: E1C8B4
names: Similarity
messages: Belongs to the UPF0046 family.

9031:SLC5A10
gene id: 9031:SLC5A10
uniprot id: F1NYX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9031:PRIMPOL
gene id: 9031:PRIMPOL
uniprot id: A0A3Q2TTB3
uniprot id: Q5F3K7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Can act both with Mn(2+) and Mg(2+) as cofactor in vitro, but Mn(2+) is the preferred cofactor in vivo.
messages: Chromosome
messages: DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them (PubMed:26626482). Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (PubMed:26694751, PubMed:27230014). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as UV lesions, R-loops and G-quadruplexes, to allow DNA replication to continue (PubMed:26694751, PubMed:27230014, PubMed:26626482). Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion (By similarity). Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase (By similarity). Also required for reinitiating stalled forks after ultraviolet (UV) damage during nuclear DNA replication (By similarity). Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (By similarity). In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: The presence of an Asp-Aaa-Glu (DxE) motif in the metal-binding active site favors the use of Mn(2+) ions to achieve optimal incoming nucleotide stabilization, especially required during primer synthesis. Glu-118 is required to stabilize the incoming nucleotide at the 3'-site.
messages: The zinc knuckle motif binds zinc and is required for the DNA primase activity. It facilitates the binding and selection of the 5'-nucleotide of the newly synthesized primer and the recognition of preferred initiation sites.

9031:EYA3
gene id: 9031:EYA3
uniprot id: A0A3Q2UIM0
uniprot id: F1ND27
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9031:SCPEP1
gene id: 9031:SCPEP1
uniprot id: Q5F3W4
names: Similarity
messages: Belongs to the peptidase S10 family.

9031:MED16
gene id: 9031:MED16
uniprot id: F1P5G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:SH3GL3
gene id: 9031:SH3GL3
uniprot id: A0A3Q2UJE9
uniprot id: Q8AXU9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Early endosome membrane
messages: Endosome membrane
messages: Expressed in early stages of follicle development up to large white follicles with highest level in small white follicles.
messages: Hens express reduced levels of SH3GL3 in ovarian follicles prior to uptake of yolk proteins.
messages: Highest level in a region associated with endocytosis of yolk proteins in developing oocytes (at protein level). Highest level in small ovarian follicles. High levels in brain and testis. Lower level in adrenal glands.
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Implicated in endocytosis of yolk proteins during oogenesis.
messages: Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1.
messages: Membrane

9031:HIST1H46L6
gene id: 9031:HIST1H46L6
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:STARD3
gene id: 9031:STARD3
uniprot id: A0A1D5PID8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9031:PDZD11
gene id: 9031:PDZD11
uniprot id: Q5ZIK2
names: Subcellular Location Annotation
messages: Cytoplasm

9031:NOS2
gene id: 9031:NOS2
uniprot id: Q90703
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: By treatment with lipopolysaccharides (LPS) or cytokines, but not in osteoclasts where they are induced by calcium and PMA (phorbol 12-myristate 13-acetate).
messages: Homodimer.
messages: Not stimulated by calcium/calmodulin.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO may serve as both a paracrine and autocrine signal for modulating osteoclast bone resorption. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 (By similarity).
messages: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
messages: cytosol

9031:LMNB2
gene id: 9031:LMNB2
uniprot id: P14732
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
messages: Belongs to the intermediate filament family.
messages: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
messages: Nucleus lamina
messages: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.

9031:NETO1
gene id: 9031:NETO1
uniprot id: A0A1D5PQM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:MEPE
gene id: 9031:MEPE
uniprot id: F1NSM7
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Asn-62 is fully glycosylated, whereas only less than 10% of Asn-293 seem to be glycosylated.
messages: Belongs to the osteoregulin family.
messages: Expressed at high levels at the middle of the calcification stage of shell formation. Expression levels are similar at 3-4 hours post-oviposition prior to entry of the egg into the uterus and at 16-17 hours post-oviposition during eggshell calcification. Expressed in tibia from 5 dpc and in mandible from 7 dpc until the end of embryonic development at 19 dpc. Expression detected first in osteoblasts, in later stages both in osteoblasts and osteocytes, and by the end of embryonic development mainly in osteocytes.
messages: In the eggshell, expressed mainly in the palisade and mammillary layers. Expression also detected in the hypertrophic zone of the epiphyseal growth plate, and in cortical and medullary bone (at protein level). Highly expressed in uterus. Not detected in the proximal oviduct, liver, magnum, duodenum and kidney.
messages: Major component of the eggshell matrix. May play an important role in the regulation of calcite growth during eggshell calcification. May also regulate the mineralization process in developing and growing bones.
messages: extracellular matrix

9031:ODR4
gene id: 9031:ODR4
uniprot id: F1NYX9
uniprot id: Q5ZKH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.
messages: Membrane

9031:MCCC2
gene id: 9031:MCCC2
uniprot id: F1P531
names: Similarity
messages: Belongs to the AccD/PCCB family.

9031:TROVE2
gene id: 9031:TROVE2
uniprot id: F1P572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9031:DCP1B
gene id: 9031:DCP1B
uniprot id: A0A3Q2U9U1
names: Similarity
messages: Belongs to the DCP1 family.

9031:MPC1L
gene id: 9031:MPC1L
uniprot id: Q5ZJW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

9031:HOXB4
gene id: 9031:HOXB4
uniprot id: P14840
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:SCFD1
gene id: 9031:SCFD1
uniprot id: F1NH65
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9031:ELAVL4
gene id: 9031:ELAVL4
uniprot id: A0A1D5PWF5
uniprot id: Q9PW22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

9031:OSBPL6
gene id: 9031:OSBPL6
uniprot id: A0A1D5P5J6
uniprot id: A0A3Q2TY05
uniprot id: F1NF23
names: Similarity
messages: Belongs to the OSBP family.

9031:ATG7
gene id: 9031:ATG7
uniprot id: Q5ZKY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (By similarity). Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress (By similarity). Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).
messages: Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5 (By similarity).
messages: Preautophagosomal structure
messages: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.

9031:TMEM86A
gene id: 9031:TMEM86A
uniprot id: A0A3Q2U4R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9031:TP63
gene id: 9031:TP63
uniprot id: A0A167VDT2
uniprot id: F1NWD0
uniprot id: Q9DEC7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Nucleus

9031:SLC6A8
gene id: 9031:SLC6A8
uniprot id: A0A1L1RLR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9031:SERPINA10
gene id: 9031:SERPINA10
uniprot id: F1NPN3
names: Similarity
messages: Belongs to the serpin family.

9031:SHOC2
gene id: 9031:SHOC2
uniprot id: E1BU15
uniprot id: Q5F4C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHOC2 family.
messages: Cytoplasm
messages: Nucleus
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes (By similarity).
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

9031:RPS6
gene id: 9031:RPS6
uniprot id: P47838
names: Function
names: PTM
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).
messages: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.

9031:HBE1
gene id: 9031:HBE1
uniprot id: Q90864
names: Similarity
messages: Belongs to the globin family.

9031:RXFP1
gene id: 9031:RXFP1
uniprot id: F1NY48
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:PIGZ
gene id: 9031:PIGZ
uniprot id: R4GJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:LOC427533
gene id: 9031:LOC427533
uniprot id: A0A1D5PN01
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:SKAP2
gene id: 9031:SKAP2
uniprot id: A0A3Q2TSS2
names: Similarity
messages: Belongs to the SKAP family.

9031:HIST1H2A3
gene id: 9031:HIST1H2A3
uniprot id: P02263
uniprot id: Q92069
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (By similarity).
messages: Monoubiquitination of Lys-120 (H2AK119Ub) gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties, leading to the recruitment of repair proteins to sites of DNA damage. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9031:PIK3R5
gene id: 9031:PIK3R5
uniprot id: Q5ZIB8
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Greatly activated by G gamma proteins.
messages: Heterodimer. Interacts with a catalytic subunit and with G beta gamma proteins (By similarity).
messages: Nucleus
messages: Regulatory subunit of the PI3K gamma complex.
messages: The heterodimerization region allows the binding to the catalytic subunit.

9031:CHP1
gene id: 9031:CHP1
uniprot id: Q5ZM44
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family. CHP subfamily.
messages: Calcium-binding or N-myristoylation are necessary for the Na(+)/H(+) exchange activities.
messages: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription. Acts as a negative regulator of the calcineurin/NFAT signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Endomembrane system
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Membrane
messages: Monomer.
messages: Nucleus
messages: Phosphorylated.
messages: cytoskeleton

9031:GH
gene id: 9031:GH
uniprot id: P08998
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Growth hormone plays an important role in growth control.
messages: Secreted

9031:IRF7
gene id: 9031:IRF7
uniprot id: Q90643
uniprot id: Q90ZD4
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the IRF-1 binding site PRD-I.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Up-regulated by poly I:C.
messages: Widely expressed with higher expression in lung, spleen and intestine.

9031:TMEM2
gene id: 9031:TMEM2
uniprot id: F1NJD8
names: Similarity
messages: Belongs to the CEMIP family.

9031:GALNT2
gene id: 9031:GALNT2
uniprot id: A0A3Q2UB17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9031:SNX33
gene id: 9031:SNX33
uniprot id: A0A1D5PC37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9031:TMED2
gene id: 9031:TMED2
uniprot id: Q5ZKB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9031:EDNRB
gene id: 9031:EDNRB
uniprot id: A0A7L4W6L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:GPR83
gene id: 9031:GPR83
uniprot id: E1C8V5
uniprot id: G3G8J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9031:NDUFC2
gene id: 9031:NDUFC2
uniprot id: Q6Q122
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9031:RMND1
gene id: 9031:RMND1
uniprot id: E1BQW2
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9031:TIMM23B
gene id: 9031:TIMM23B
uniprot id: E1BR29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

9031:HK2
gene id: 9031:HK2
uniprot id: Q8AYP7
names: Similarity
messages: Belongs to the hexokinase family.

9031:GPRC6A
gene id: 9031:GPRC6A
uniprot id: E1C4L4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:CAPN8
gene id: 9031:CAPN8
uniprot id: F1P052
names: Similarity
messages: Belongs to the peptidase C2 family.

9031:SRPRB
gene id: 9031:SRPRB
uniprot id: Q5ZJA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:LOC107052820
gene id: 9031:LOC107052820
uniprot id: A0A1D5P6V7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:SATB1
gene id: 9031:SATB1
uniprot id: A0A1D5PV61
uniprot id: E1BRH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

9031:HIKESHI
gene id: 9031:HIKESHI
uniprot id: Q5ZK09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages (By similarity).
messages: Belongs to the OPI10 family.
messages: Nucleus
messages: cytosol

9031:KIF3A
gene id: 9031:KIF3A
uniprot id: F1NIP3
uniprot id: Q5F3C2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:INO80D
gene id: 9031:INO80D
uniprot id: A0A1D5P5H5
names: Subcellular Location Annotation
messages: Nucleus

9031:LOC427973
gene id: 9031:LOC427973
uniprot id: A0A1L1RJ61
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:MGAT4A
gene id: 9031:MGAT4A
uniprot id: Q5F407
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity).
messages: Golgi apparatus membrane
messages: Inhibited by UDP.
messages: N-glycosylated.
messages: Secreted

9031:PDE3A
gene id: 9031:PDE3A
uniprot id: E1C0B2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9031:TRIM59
gene id: 9031:TRIM59
uniprot id: Q5ZMD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Endoplasmic reticulum membrane
messages: Interacts with ECSIT.
messages: May serve as a multifunctional regulator for innate immune signaling pathways.

9031:SPRY2
gene id: 9031:SPRY2
uniprot id: F1NZG9
uniprot id: Q9PTL2
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as an antagonist of FGF-induced retinal lens fiber differentiation (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). May play an important role in FGF-mediated patterning of the mid/hindbrain region by acting to modulate the signaling effects of FGF8 (PubMed:10662503).
messages: At the 4- to 5-somite stage (4/5S) found in the embryo in scattered cells across the neural plate in the presumptive mid/ hindbrain region (PubMed:10662503). At 7/8S found in the isthmus and throughout the presumptive r1 territory. Between 10-14S stage found throughout the R1 region and at the isthmic constriction (PubMed:10662503). By 26S the anterior limit of expression extends into the posterior midbrain region and this pattern of expression is maintained at later stages (PubMed:10662503).
messages: Belongs to the sprouty family.
messages: Brain and interlimb region.
messages: By FGF signaling.
messages: Cytoplasm
messages: Membrane
messages: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

9031:PIN4
gene id: 9031:PIN4
uniprot id: F1NCD7
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

9031:RAB3C
gene id: 9031:RAB3C
uniprot id: E1C105
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9031:NPTX2
gene id: 9031:NPTX2
uniprot id: E1C7S1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:ISPD
gene id: 9031:ISPD
uniprot id: A0A3Q2U4A9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Homodimer.
messages: cytosol

9031:PSMA4
gene id: 9031:PSMA4
uniprot id: F1NC02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9031:CLSTN3
gene id: 9031:CLSTN3
uniprot id: E1C3B9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

9031:PCDHA1
gene id: 9031:PCDHA1
uniprot id: Q6R0J0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:AHCY
gene id: 9031:AHCY
uniprot id: A0A1D5PPA8
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

9031:ORMDL3
gene id: 9031:ORMDL3
uniprot id: R4GJY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9031:SARAF
gene id: 9031:SARAF
uniprot id: Q5ZK00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:TMEM97
gene id: 9031:TMEM97
uniprot id: F1N859
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Endoplasmic reticulum membrane
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

9031:MITF
gene id: 9031:MITF
uniprot id: B6E281
uniprot id: O73871
uniprot id: Q9IAU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9031:SSBP3
gene id: 9031:SSBP3
uniprot id: A0A1D5PM35
uniprot id: A0A1D5PX87
uniprot id: Q98948
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in embryonic fibroblasts and chondrocytes.
messages: May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.
messages: Nucleus

9031:LOC107055267
gene id: 9031:LOC107055267
uniprot id: A0A1D5PBX6
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:GINS3
gene id: 9031:GINS3
uniprot id: A0A1D5PWI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9031:THPO
gene id: 9031:THPO
uniprot id: Q6IYE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9031:RTCB
gene id: 9031:RTCB
uniprot id: F1NYI3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

9031:DCK
gene id: 9031:DCK
uniprot id: Q5ZMF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DCK/DGK family.
messages: Expressed at high levels in adult intestine, spleen, thymus and testis with lower levels in skeletal muscle and eye. In the embryo, expressed at higher levels until day 10 with lower levels in later stages.
messages: Homodimer.
messages: Nucleus
messages: Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:27906638). Displays highest activity against deoxycytidine followed by deoxyadenosine and then deoxyguanosine (PubMed:27906638). Shows only very minor activity against deoxyuridine and deoxythymidine (PubMed:27906638).

9031:MXRA8
gene id: 9031:MXRA8
uniprot id: Q90WI4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer in cis. Does not appear to form trans-homodimers.
messages: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro.

9031:KDSR
gene id: 9031:KDSR
uniprot id: Q5ZKZ6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9031:CSRP2
gene id: 9031:CSRP2
uniprot id: P50460
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Totally down-regulated in transformed cells. May therefore take part in the control of cell growth and differentiation.

9031:NIM1K
gene id: 9031:NIM1K
uniprot id: E1C6B4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9031:EMC1
gene id: 9031:EMC1
uniprot id: Q5ZL00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

9031:FAHD1
gene id: 9031:FAHD1
uniprot id: F1NXZ7
names: Similarity
messages: Belongs to the FAH family.

9031:PHTF1
gene id: 9031:PHTF1
uniprot id: E1BZ77
names: Subcellular Location Annotation
messages: Membrane

9031:OVAL
gene id: 9031:OVAL
uniprot id: A0A2H4Y7U9
uniprot id: A0A411G5W6
uniprot id: P01012
names: Allergen
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the serpin family.
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: Can cause an allergic reaction in humans.
messages: Down-regulated by dietary stress. Decreased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens.
messages: During storage of fertilized and non-fertilized eggs or under alkaline conditions, the native ovalbumin conformer (N-ovalbumin) is transformed into a thermostabilized conformer, S-ovalbumin. Ser-165, Ser-237 and Ser-321 take on a D-configuration in this conformer and may be responsible for the thermostability.
messages: Homodimer.
messages: Major protein of egg white. Expressed in the magnum of the oviduct (at protein level) (PubMed:25436390).
messages: Non-inhibitory serpin. Storage protein of egg white.
messages: Secreted
messages: The uncleaved signal peptide becomes available for membrane translocation of ovalbumin when the nascent chain is 50 to 60 residues long. The hydrophobic sequence, which lies between residues 27 and 43, folds back on the preceding residues to form an amphipathic hairpin structure which is the signal element recognized by the membrane.
messages: Undergoes proteolytic cleavage first at the canonical P1-P1' site, and then at the P8-P7 site by subtilisin.
messages: Unlike other serpins, after protease cleavage at the P-P' site, ovalbumin does not have the ability to undergo the conformational transition into the loop-inserted reactive-center-containing thermostabilized form. The bulky arginine residue (Arg-340) at the hinge region appears to be responsible for this lack of loop-inserted conformational change, but not for the absence of serpin inhibitory activity.

9031:CATHB1
gene id: 9031:CATHB1
uniprot id: Q5F378
uniprot id: R4GJF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cathelicidin family.
messages: Detected in bursa of Fabricius, in filamentous structures surrounding the basal and lateral surfaces of bursal M cells (at protein level). Detected in bursa of Fabricius, in secretory enterocytes of the interfollicular bursal epithelium, but not in M cells.
messages: Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). May play a role in the innate immune response.
messages: Secreted

9031:SRPRA
gene id: 9031:SRPRA
uniprot id: Q5F390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

9031:MST1R
gene id: 9031:MST1R
uniprot id: Q08757
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:LOC107057524
gene id: 9031:LOC107057524
uniprot id: A0A1D5NZB0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

9031:GLRA3
gene id: 9031:GLRA3
uniprot id: A0A1D5PDX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9031:DNASE2B
gene id: 9031:DNASE2B
uniprot id: Q2XP49
names: Similarity
messages: Belongs to the DNase II family.

9031:CDHR1
gene id: 9031:CDHR1
uniprot id: Q8UVJ7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein.

9031:PDHX
gene id: 9031:PDHX
uniprot id: Q5F3G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

9031:LIX1
gene id: 9031:LIX1
uniprot id: Q8UVV7
names: Developmental Stage
names: Similarity
messages: Belongs to the LIX1 family.
messages: Transiently expressed in the nascent hindlimb bud between Hamburger-Hamilton stages 15 and 19. Also found in the basal plate of rhombomeres 3 and 5, in pharyngeal and in foregut mesenchyme and in all facial primordia except for the mandibular arches.

9031:LAMP1
gene id: 9031:LAMP1
uniprot id: P05300
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: (Microbial infection) Plays an essential role in efficient replication and spread of Marek's disease virus, by facilitating viral cell-to-cell spread.
messages: Belongs to the LAMP family.
messages: Cell membrane
messages: Cytolytic granule membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis. Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
messages: Lysosome membrane

9031:NUP58
gene id: 9031:NUP58
uniprot id: A0A1D5PUQ9
uniprot id: Q5ZKL1
names: Subcellular Location Annotation
messages: nuclear pore complex

9031:AMACR
gene id: 9031:AMACR
uniprot id: Q5ZL63
names: Similarity
messages: Belongs to the CoA-transferase III family.

9031:BPGM
gene id: 9031:BPGM
uniprot id: Q5ZHV4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9031:ACP1
gene id: 9031:ACP1
uniprot id: A0A1D5P9Z1
uniprot id: Q5ZKG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

9031:PAFAH1B1
gene id: 9031:PAFAH1B1
uniprot id: Q9PTR5
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, NDE1 and NDEL1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Expressed in the intermediate and lateral mesoderm, posterior neural tube, notochord and somites of stage 9 embryos. Expressed in the neural tube, roof plate, notochord, somites, dermomymotomes and eye of stage 20 embryos. This expression pattern persists in stage 27 embryos, where expression is also seen in the heart, intestine and dorsal aorta. Weakly and uniformly expressed in the stage 35 embryo.
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: centrosome
messages: cytoskeleton

9031:C12orf49
gene id: 9031:C12orf49
uniprot id: Q5ZJE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.

9031:CSPG5
gene id: 9031:CSPG5
uniprot id: Q9DF69
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds TNC and TNR. The 80 kDa form but not the 140 kDa form can bind TNC and TNR when expressed at the cell surface.
messages: Cell membrane
messages: Different forms exist: the 140 kDa form (also reported as 130 kDa), which probably consists of the entire protein, and the 38 and 80 kDa forms, which are probably cleaved in their N-terminus. Increase in synaptic activity, results in shedding of the extracellular domain and expression at the cell surface of a 38 kDa form. A form of 200 kDa has also been reported, which is probably hyperglycosylated.
messages: Expressed in astroglial and neuronal surfaces in different parts of the embryonic brain. Expressed in adult brain and retina (at protein level).
messages: May function as a growth and differentiation factor involved in neuritogenesis and more particularly in neurite extension.
messages: N-glycosylated.
messages: O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, the 200 kDa form is the only one containing chondroitin sulfate glycans.
messages: The 80 kDa and 200 kDa forms were detected only during embryonic development. The 80 kDa form reaches a maximum of expression at 14 dpc/15 dpc and then decreases gradually. The 140 kDa form is already detected at 7 dpc. The 130 and 140 kDa forms reach their maximal expression at 20 dpc (at protein level).

9031:SLC7A7
gene id: 9031:SLC7A7
uniprot id: A0A1D5P6T2
names: Subcellular Location Annotation
messages: Membrane

9031:CYP2C23b
gene id: 9031:CYP2C23b
uniprot id: P20678
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: By phenobarbital.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9031:MLH1
gene id: 9031:MLH1
uniprot id: A0A1D5P146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9031:BZW1
gene id: 9031:BZW1
uniprot id: Q5ZLT7
names: Function
names: Similarity
messages: Belongs to the BZW family.
messages: Translation initiation regulator which may repress repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity).

9031:PSPH
gene id: 9031:PSPH
uniprot id: E1C9F4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

9031:APP
gene id: 9031:APP
uniprot id: F1P0B2
uniprot id: Q9DGJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus
messages: Secreted

9031:DSEL
gene id: 9031:DSEL
uniprot id: A0A1D5PUS3
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

9031:MAPK4
gene id: 9031:MAPK4
uniprot id: Q5F3W3
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.
messages: Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

9031:CTNND1
gene id: 9031:CTNND1
uniprot id: A0A3Q2U1A5
uniprot id: A0A3Q2U7N3
uniprot id: A0A3Q2UEG2
names: Similarity
messages: Belongs to the beta-catenin family.

9031:STUB1
gene id: 9031:STUB1
uniprot id: Q5ZHY5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (By similarity). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity).
messages: Homodimer.
messages: The U-box domain is required for the ubiquitin protein ligase activity.

9031:KRT7
gene id: 9031:KRT7
uniprot id: A0A146F0A0
uniprot id: O93532
names: Developmental Stage
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Abundant in the cochlea of the inner ear, where it is found in the cells of the tegmentum vasculosum. Lower levels also found in the heart and forebrain.
messages: Belongs to the intermediate filament family.
messages: Heterotetramer of two type I and two type II keratins.
messages: Specifically expressed at the late developmental stages in the cochlea.

9031:DDX55
gene id: 9031:DDX55
uniprot id: Q5ZLN8
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
messages: Probable ATP-binding RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9031:LOC422442
gene id: 9031:LOC422442
uniprot id: E1C5U2
names: Similarity
messages: Belongs to the MS4A family.

9031:EXTL3
gene id: 9031:EXTL3
uniprot id: F1NGB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

9031:GSC
gene id: 9031:GSC
uniprot id: P53545
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Involved in the development of the organizer region in the gastrula (Hensen node in chicken).
messages: Is first expressed in the Koller's sickle (a crescent shaped thickening located at the edge of the posterior marginal zone), and then it is detected in Hensen node which is considered as the chick organizer. Later expression is seen in the anterior most region of the head process (cells that contribute to the prechordal plate at the midline of the pharyngeal mesendoderm).
messages: Nucleus

9031:INTS2
gene id: 9031:INTS2
uniprot id: Q5ZKU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 2 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus membrane

9031:C6orf120
gene id: 9031:C6orf120
uniprot id: F1NYK5
uniprot id: Q5ZLK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: Secreted

9031:C3
gene id: 9031:C3
uniprot id: Q90633
names: Subcellular Location Annotation
messages: Secreted

9031:OCM1
gene id: 9031:OCM1
uniprot id: P43305
names: Function
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the parvalbumin family.
messages: Binds two calcium ions.
messages: Restricted to the thymic stroma.
messages: This parvalbumin has an isoelectric point of 4.6.

9031:RAB3IP
gene id: 9031:RAB3IP
uniprot id: E1C029
names: Similarity
messages: Belongs to the SEC2 family.

9031:UPRT
gene id: 9031:UPRT
uniprot id: Q5ZIJ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPRTase family.
messages: Cytoplasm
messages: Nucleus
messages: The uracil binding region known from UPRTases is missing.

9031:GRIK2
gene id: 9031:GRIK2
uniprot id: A0A1D5PFB0
uniprot id: A0A3Q2U6R3
uniprot id: F1NU20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9031:CXCL13
gene id: 9031:CXCL13
uniprot id: A0A1L1RZN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9031:PISD
gene id: 9031:PISD
uniprot id: F1NIN3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

9031:C16orf87
gene id: 9031:C16orf87
uniprot id: A0A3Q3A8E8
names: Similarity
messages: Belongs to the UPF0547 family.

9031:HCFC2
gene id: 9031:HCFC2
uniprot id: A0A1D5PJV0
names: Subcellular Location Annotation
messages: Nucleus

9031:CHEK1
gene id: 9031:CHEK1
uniprot id: Q8AYC9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated through phosphorylation by atr or atm in response to DNA damage or inhibition of DNA replication.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by ATR in a RAD17-dependent manner in response to ultraviolet irradiation and inhibition of DNA replication. Phosphorylated by ATM in response to ionizing irradiation (By similarity). Phosphorylation at Ser-345 induces a change in the conformation of the protein and activates the kinase activity. Phosphorylation at Ser-345 also increases binding to 14-3-3 proteins and promotes nuclear retention (PubMed:12554671).
messages: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:12554671). May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. This inhibits their activity through proteasomal degradation, nucleo-cytoplasmic shuttling and inhibition by proteins of the 13-3-3 family. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May promote DNA repair, regulate chromatin assembly and the transcription of genes that regulate cell-cycle progression. May also play a role in replication fork maintenance (By similarity).
messages: The autoinhibitory region (AIR) inhibits the activity of the kinase domain.
messages: centrosome

9031:DMRT3
gene id: 9031:DMRT3
uniprot id: E1C2G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9031:EPHX1L
gene id: 9031:EPHX1L
uniprot id: E1C7F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Microsome membrane

9031:ART4
gene id: 9031:ART4
uniprot id: B6RDJ8
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9031:C22orf39
gene id: 9031:C22orf39
uniprot id: A0A1L1RQR8
names: Similarity
messages: Belongs to the UPF0545 family.

9031:ADGRF4
gene id: 9031:ADGRF4
uniprot id: A0A3Q2UI82
names: Subcellular Location Annotation
messages: Membrane

9031:PATL1
gene id: 9031:PATL1
uniprot id: A0A1D5PJZ8
names: Similarity
messages: Belongs to the PAT1 family.

9031:GPR12
gene id: 9031:GPR12
uniprot id: F1P2L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:TMBIM4
gene id: 9031:TMBIM4
uniprot id: E1C1Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9031:LSM5
gene id: 9031:LSM5
uniprot id: A0A1D5PYI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9031:RPS6KB1
gene id: 9031:RPS6KB1
uniprot id: Q5ZLW5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9031:PPY
gene id: 9031:PPY
uniprot id: P68248
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
messages: Secreted

9031:UCHL3
gene id: 9031:UCHL3
uniprot id: Q9PW67
names: Similarity
messages: Belongs to the peptidase C12 family.

9031:GCG
gene id: 9031:GCG
uniprot id: P68259
uniprot id: Q3HWX0
uniprot id: Q3HWX1
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
messages: Potent stimulator of glucose-dependent insulin release. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation.
messages: Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
messages: Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1 and GLP-2. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide (By similarity).
messages: Secreted
messages: Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.

9031:TACC3
gene id: 9031:TACC3
uniprot id: F1NCL7
uniprot id: Q5ZLP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9031:TMEM189
gene id: 9031:TMEM189
uniprot id: F1NKD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9031:NFIB
gene id: 9031:NFIB
uniprot id: A0A1D5NWM2
uniprot id: A0A1D5NZS7
uniprot id: A0A1D5PQ76
uniprot id: P17924
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

9031:LOC107055197
gene id: 9031:LOC107055197
uniprot id: E1C5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9031:DCLK3
gene id: 9031:DCLK3
uniprot id: A0A1D5PTR1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9031:RLBP1
gene id: 9031:RLBP1
uniprot id: E1C1U1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DEGS1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.

9031:P3H2
gene id: 9031:P3H2
uniprot id: Q6JHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leprecan family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (By similarity). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity).
messages: Sarcoplasmic reticulum

9031:ADGRG6
gene id: 9031:ADGRG6
uniprot id: F1P1B2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:LOC396380
gene id: 9031:LOC396380
uniprot id: F1NQS2
uniprot id: P26697
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Alpha family.
messages: Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.
messages: Cytoplasm
messages: Homodimer or heterodimer (with a subunit from group CL-4).
messages: The variations were found from AA sequencing and imply there are multiple forms of CL-3.

9031:DUSP3
gene id: 9031:DUSP3
uniprot id: A0A1D5PI23
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9031:WASF1
gene id: 9031:WASF1
uniprot id: E1C9B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9031:DERL2
gene id: 9031:DERL2
uniprot id: A0A1D5PW06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9031:WNT7B
gene id: 9031:WNT7B
uniprot id: Q3L254
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Detected in the anterior parencephalon and secondary prosencephalon at stages 20 and 24. Expressed in the ventricular epithelium of the spinal cord at the latest stages.
messages: Expressed in differentiating lens fiber cells.
messages: Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Produced by alternative splicing.
messages: Secreted
messages: extracellular matrix

9031:TFB1M
gene id: 9031:TFB1M
uniprot id: E1BWX0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

9031:INS
gene id: 9031:INS
uniprot id: P67970
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

9031:NDUFB10
gene id: 9031:NDUFB10
uniprot id: E1C6C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

9031:ARPC5
gene id: 9031:ARPC5
uniprot id: Q5ZMV5
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9031:HOMER1
gene id: 9031:HOMER1
uniprot id: F1NBG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9031:RBP2
gene id: 9031:RBP2
uniprot id: F1NZY4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:MEGF10
gene id: 9031:MEGF10
uniprot id: E1C393
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:NEIL2
gene id: 9031:NEIL2
uniprot id: E1BYL0
names: Similarity
messages: Belongs to the FPG family.

9031:WFIKKN2
gene id: 9031:WFIKKN2
uniprot id: E1C6W9
names: Similarity
messages: Belongs to the WFIKKN family.

9031:HESX1
gene id: 9031:HESX1
uniprot id: F1NTN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

9031:TBX15
gene id: 9031:TBX15
uniprot id: F1NA14
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:DCT
gene id: 9031:DCT
uniprot id: O93505
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tyrosinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Melanocytes and retinal pigmented epithelium.
messages: Melanosome
messages: Melanosome membrane
messages: Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).

9031:ALDH1L2
gene id: 9031:ALDH1L2
uniprot id: F1P130
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9031:RLTPR
gene id: 9031:RLTPR
uniprot id: E1BZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9031:COPB1
gene id: 9031:COPB1
uniprot id: Q5ZIA5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Expressed more highly in male embryonic day 3 (3 dpc) and 5 dpc whole embryos, paired urogenital system at 7 dpc and gonads at 9 dpc than in females.
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

9031:COPG1
gene id: 9031:COPG1
uniprot id: Q5F402
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9031:GATAD1
gene id: 9031:GATAD1
uniprot id: F1P024
names: Subcellular Location Annotation
messages: Nucleus

9031:PHACTR2
gene id: 9031:PHACTR2
uniprot id: A0A1D5PSM4
uniprot id: A0A3Q2UHA2
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9031:TLR2
gene id: 9031:TLR2
uniprot id: C4PC51
uniprot id: Q9DGB6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Toll-like receptor family.
messages: Binds MYD88 (via TIR domain).
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Highly expressed in ovary. Also detected in brain, heart, lung, liver, spleen and kidney, and at low levels in gizzard, muscle, testis and proventriculus.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Membrane
messages: N-glycosylated.
messages: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).

9031:SNX14
gene id: 9031:SNX14
uniprot id: Q5ZIZ8
names: Similarity
messages: Belongs to the sorting nexin family.

9031:PMEPA1
gene id: 9031:PMEPA1
uniprot id: Q5ZJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9031:HRH1
gene id: 9031:HRH1
uniprot id: F1NEN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:TEKT5
gene id: 9031:TEKT5
uniprot id: E1C109
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

9031:CDIP1
gene id: 9031:CDIP1
uniprot id: A0A1D5PGK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

9031:ERG
gene id: 9031:ERG
uniprot id: A0A1D5P6W0
uniprot id: Q8UUU0
uniprot id: Q90837
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcriptional activator.
messages: Belongs to the ETS family.
messages: Expressed in mesoderm- and, to a lesser extent, in ectoderm-derived tissues.
messages: Nucleus

9031:PNPLA7
gene id: 9031:PNPLA7
uniprot id: B3TZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:ARL11
gene id: 9031:ARL11
uniprot id: F1N8V9
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9031:FGF19
gene id: 9031:FGF19
uniprot id: R4GMB5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9031:APOA1
gene id: 9031:APOA1
uniprot id: P08250
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Homodimer.
messages: Major protein of plasma HDL, also found in chylomicrons.
messages: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).
messages: Secreted

9031:PNPT1
gene id: 9031:PNPT1
uniprot id: A0A1D5NZ09
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

9031:RPL37A
gene id: 9031:RPL37A
uniprot id: P32046
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9031:CASK
gene id: 9031:CASK
uniprot id: A0A1D5PB73
uniprot id: A0A3Q2ULY1
names: Similarity
messages: Belongs to the MAGUK family.

9031:PDIA2
gene id: 9031:PDIA2
uniprot id: A0A1D5PKM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

9031:TCF7L2
gene id: 9031:TCF7L2
uniprot id: A0A1D5P979
uniprot id: E1BYU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9031:LHX9
gene id: 9031:LHX9
uniprot id: Q90881
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in the limb mesenchyme throughout stages 16 to 32. Expressed in the prospective wing bud at stage 16. Expressed in the leg bud at stage 17. Expressed in the forebrain throughout stages 14 to 21.
messages: May be involved in gonadal development.
messages: Nucleus

9031:SRSF2
gene id: 9031:SRSF2
uniprot id: P30352
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA.
messages: Nucleus

9031:SLC12A9
gene id: 9031:SLC12A9
uniprot id: A0A1D5PB75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9031:CNTNAP1
gene id: 9031:CNTNAP1
uniprot id: F1NAE5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

9031:RAE1
gene id: 9031:RAE1
uniprot id: Q5ZJA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: spindle pole

9031:DRAXIN
gene id: 9031:DRAXIN
uniprot id: B6ZI38
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the draxin family.
messages: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Binds directly to the neurites and growth cones.
messages: Expressed transiently during development of the brain and spinal cord, especially in the roof plate and the dorsal lip of the dermomyotome. Also present at the dorsolateral basement membrane of the spinal cord (at protein level).
messages: Secreted

9031:FAM150B
gene id: 9031:FAM150B
uniprot id: A0A1D5PAD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9031:FTCD
gene id: 9031:FTCD
uniprot id: F1NE33
uniprot id: Q9YH58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds and promotes bundling of vimentin filaments originating from the Golgi.
messages: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
messages: Golgi apparatus
messages: Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.
messages: In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.
messages: In the N-terminal section; belongs to the formiminotransferase family.
messages: centriole
messages: cytosol

9031:GNPNAT1
gene id: 9031:GNPNAT1
uniprot id: E1C0V1
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9031:IMP3
gene id: 9031:IMP3
uniprot id: A0A3Q2U8J0
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

9031:SH3GLB1
gene id: 9031:SH3GLB1
uniprot id: A0A1D5P3G5
uniprot id: Q5ZIR1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Homodimer, and heterodimer with SH3GLB2. Binds BAX. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1 (By similarity).
messages: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity).
messages: Membrane
messages: Mitochondrion outer membrane

9031:HIST1H4B
gene id: 9031:HIST1H4B
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:PCNT
gene id: 9031:PCNT
uniprot id: F1NGJ4
names: Subcellular Location Annotation
messages: centrosome

9031:YWHAQ
gene id: 9031:YWHAQ
uniprot id: Q5ZMD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.

9031:PTGR2
gene id: 9031:PTGR2
uniprot id: Q5F370
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

9031:AP3S1
gene id: 9031:AP3S1
uniprot id: Q5ZJE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9031:HTT
gene id: 9031:HTT
uniprot id: E1BZK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

9031:TOR4A
gene id: 9031:TOR4A
uniprot id: F1NLT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Membrane

9031:CDC2L1
gene id: 9031:CDC2L1
uniprot id: A0A1D5NZU4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

9031:ADAMTS12
gene id: 9031:ADAMTS12
uniprot id: A0A3Q2TUD5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9031:IFT122
gene id: 9031:IFT122
uniprot id: A0A1D5PQD0
names: Subcellular Location Annotation
messages: cilium

9031:SYT14
gene id: 9031:SYT14
uniprot id: A0A3Q2U603
uniprot id: E1C1Z1
names: Similarity
messages: Belongs to the synaptotagmin family.

9031:MID1
gene id: 9031:MID1
uniprot id: Q71R46
uniprot id: Q90WD1
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

9031:CNTN1
gene id: 9031:CNTN1
uniprot id: P14781
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: Interacts with TNR.
messages: Mediates cell surface interactions during nervous system development. Interaction with TNR enhances the neurite outgrowth.

9031:KLHL9
gene id: 9031:KLHL9
uniprot id: Q5ZLD3
names: Function
names: Subunit
messages: Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB (By similarity).
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).

9031:DKC1
gene id: 9031:DKC1
uniprot id: Q5ZJH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pseudouridine synthase TruB family.
messages: Cajal body
messages: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance.
messages: Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate.
messages: nucleolus

9031:CDC26
gene id: 9031:CDC26
uniprot id: A0A3Q2UD09
names: Similarity
messages: Belongs to the CDC26 family.

9031:DCAF1
gene id: 9031:DCAF1
uniprot id: A0A1D5PF43
uniprot id: A0A1D5PJD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

9031:FAM172A
gene id: 9031:FAM172A
uniprot id: Q5ZK44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: May play role in the regulation of alternative splicing. May have hydrolase activity.
messages: Nucleus

9031:CYP2AC1
gene id: 9031:CYP2AC1
uniprot id: F1NFF7
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:MME
gene id: 9031:MME
uniprot id: Q67BJ2
names: Cofactor
messages: Binds 1 zinc ion per subunit.

9031:SNPH
gene id: 9031:SNPH
uniprot id: A0A1D5PEN5
names: Subcellular Location Annotation
messages: Membrane

9031:KIZ
gene id: 9031:KIZ
uniprot id: Q5ZK13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9031:EXOC6B
gene id: 9031:EXOC6B
uniprot id: F1NZL5
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9031:COX20
gene id: 9031:COX20
uniprot id: R4GH54
names: Similarity
messages: Belongs to the COX20 family.

9031:NUF2
gene id: 9031:NUF2
uniprot id: A0A140T8H9
uniprot id: Q76I90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12829748). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity).
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which is composed of at least NDC80/HEC1 and CDCA1.
messages: Cytoplasm
messages: Nucleus
messages: centrosome
messages: kinetochore

9031:FES
gene id: 9031:FES
uniprot id: F1NXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: cytoskeleton

9031:SUMO3
gene id: 9031:SUMO3
uniprot id: Q5ZHQ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins (By similarity).
messages: PML body
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I (By similarity).

9031:BEST3
gene id: 9031:BEST3
uniprot id: E1C882
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

9031:GPR182
gene id: 9031:GPR182
uniprot id: A0A1D5PU79
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9031:WNT5A
gene id: 9031:WNT5A
uniprot id: Q9YGX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9031:TMEM17
gene id: 9031:TMEM17
uniprot id: E1BY51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM17 family.
messages: Part of the tectonic-like complex (also named B9 complex).
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: cilium membrane

9031:RAMP2
gene id: 9031:RAMP2
uniprot id: A7UH64
names: Similarity
messages: Belongs to the RAMP family.

9031:NAGA
gene id: 9031:NAGA
uniprot id: F1NJF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9031:SDHB
gene id: 9031:SDHB
uniprot id: A0A1D5PIF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9031:ZDHHC5
gene id: 9031:ZDHHC5
uniprot id: Q2THW5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:NIPA1
gene id: 9031:NIPA1
uniprot id: A0A1D5PVN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9031:LOC415852
gene id: 9031:LOC415852
uniprot id: E1BYE0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:GTPBP4
gene id: 9031:GTPBP4
uniprot id: Q5ZM18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

9031:MYO18A
gene id: 9031:MYO18A
uniprot id: A0A3Q2UDG5
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:MAP1LC3C
gene id: 9031:MAP1LC3C
uniprot id: E1C1H3
names: Similarity
messages: Belongs to the ATG8 family.

9031:TACR3
gene id: 9031:TACR3
uniprot id: F1NJ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:MEAF6
gene id: 9031:MEAF6
uniprot id: A0A1D5P1W0
uniprot id: A0A1D5PS50
uniprot id: F1P3G5
uniprot id: Q5ZIX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

9031:CDK1
gene id: 9031:CDK1
uniprot id: F1NBD7
uniprot id: P13863
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase.
messages: Nucleus
messages: Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts negative regulator of entry into mitosis (G2 to M transition).
messages: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. May play a role in regulating the amplitude of the cyclic expression of circadian clock genes.
messages: Thr-14 and Tyr-15 are phosphorylated maximally during G2 phase, but dephosphorylated abruptly at the G2/M transition. Phosphorylation at Thr-14 and Tyr-15 inactivates the enzyme. During M phase it is also phosphorylated on Thr-161. Finally during G1 phase it is phosphorylated on Ser-277.
messages: centrosome

9031:ZNF687
gene id: 9031:ZNF687
uniprot id: A0A1D5PTU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

9031:KCNQ3
gene id: 9031:KCNQ3
uniprot id: A0A1D5PFY9
uniprot id: A0A1D5PTN9
uniprot id: A0A3Q2UHP4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:THRB
gene id: 9031:THRB
uniprot id: F1NWE9
uniprot id: P68306
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

9031:REV3L
gene id: 9031:REV3L
uniprot id: F1NQT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9031:PPP4R3A
gene id: 9031:PPP4R3A
uniprot id: F1NPW9
names: Similarity
messages: Belongs to the SMEK family.

9031:HIST2H4B
gene id: 9031:HIST2H4B
uniprot id: P62801
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

9031:NME2
gene id: 9031:NME2
uniprot id: O57535
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cell membrane
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

9031:RPLP0
gene id: 9031:RPLP0
uniprot id: P47826
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Cytoplasm
messages: Nucleus
messages: P0 forms a pentameric complex by interaction with dimers of P1 and P2.
messages: Phosphorylated.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

9031:PKN3
gene id: 9031:PKN3
uniprot id: A0A3Q3B2F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

9031:VCAN
gene id: 9031:VCAN
uniprot id: Q90953
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Disappears after the cartilage development.
messages: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
messages: Prechondrogenic condensation area of developing limb buds.
messages: extracellular matrix
messages: interphotoreceptor matrix
messages: photoreceptor outer segment

9031:FOXL2
gene id: 9031:FOXL2
uniprot id: Q5J7N5
names: Subcellular Location Annotation
messages: Nucleus

9031:ALCAM
gene id: 9031:ALCAM
uniprot id: P42292
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM (PubMed:1931049, PubMed:22421359). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (PubMed:1873027, PubMed:22421359). Mediates outgrowth and pathfinding for retinal ganglion cell axons (PubMed:22421359).
messages: Cell membrane
messages: Detected in embryo (PubMed:1931049, PubMed:1608932). Detected in embryonic spinal cord and embryonic brain (PubMed:1873027, PubMed:1313497). Within the spinal cord it is localized to axons in the dorsal funiculus, midline floor plate cells, and motoneurons (PubMed:1873027). Detected in embryonic epithelia and brain (PubMed:1608932). After hatching, detected in bursa of Fabricius and thymus (PubMed:1608932). Detected on embryonic retinal ganglion cell axon growth cones (at protein level) (PubMed:22421359). Detected in embryonic retina and in the optic fiber layer, which is composed of retinal ganglion cell axons and their growth cones (PubMed:22421359).
messages: Glycosylated.
messages: Homodimer. Interacts (via extracellular domain) with CD6 (via extracellular domain). Homodimerization and interaction with CD6 involve the same region and cannot occur simultaneously. The affinity for CD6 is much higher than the affinity for self-association.
messages: The CD6 binding site is located in the N-terminal Ig-like domain.
messages: Widely expressed during embryonic development.
messages: axon
messages: dendrite

9031:LIMK2
gene id: 9031:LIMK2
uniprot id: P53666
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Binds ROCK1 and LKAP.
messages: Expressed predominantly in the lung, and faintly in the kidney, liver, brain, spleen, gizzard, and intestine.
messages: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP.
messages: centrosome
messages: spindle

9031:MVB12A
gene id: 9031:MVB12A
uniprot id: Q5ZJX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MVB12 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I).
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity).
messages: Cytoplasm
messages: Endosome
messages: Late endosome membrane

9031:SLC8A3
gene id: 9031:SLC8A3
uniprot id: A0A3Q2UKZ9
uniprot id: F1P023
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

9031:SCGN
gene id: 9031:SCGN
uniprot id: E1BY74
names: Subcellular Location Annotation
messages: Cytoplasm

9031:ACTR10
gene id: 9031:ACTR10
uniprot id: Q5ZID3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

9031:PSMA3
gene id: 9031:PSMA3
uniprot id: Q5ZLI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9031:LGALS1B
gene id: 9031:LGALS1B
uniprot id: P23668
names: Function
names: Subunit
names: Tissue Specificity
messages: Homodimer.
messages: Mainly in the liver (adult), mainly in the muscle (embryo).
messages: This protein binds beta-galactoside. Its physiological function is not yet known. It may be involved in the regulation of differentiation.

9031:LMX1B
gene id: 9031:LMX1B
uniprot id: P53413
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifies dorsal cell fate during limb development.

9031:NAV3
gene id: 9031:NAV3
uniprot id: A0A3Q2UA21
uniprot id: A0A3Q2UDJ2
uniprot id: A0A3Q2UKU2
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9031:PGM1
gene id: 9031:PGM1
uniprot id: F1NN63
uniprot id: Q2UZR2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9031:C2orf40
gene id: 9031:C2orf40
uniprot id: A0A8K1B0E1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

9031:VTI1A
gene id: 9031:VTI1A
uniprot id: A0A1D5PRR1
uniprot id: A0A1L1RKZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

9031:FGD5
gene id: 9031:FGD5
uniprot id: E1BQN2
names: Subcellular Location Annotation
messages: cytoskeleton

9031:PGR
gene id: 9031:PGR
uniprot id: P07812
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Nucleus
messages: Oviduct and bursa of Fabricius.
messages: Phosphorylation of Ser-529 is sharply increased upon progesterone treatment, whereas phosphorylation of Ser-210 and Ser-259 is modestly induced by progesterone.
messages: Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-385, the main site of sumoylation, is repressed by ubiquitination on the same site (By similarity).
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
messages: Ubiquitinated. Ubiquitination is increased by progesterone and represses sumoylation at the same site (By similarity).

9031:KCNJ3
gene id: 9031:KCNJ3
uniprot id: Q90854
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity).
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat (By similarity).

9031:SLC51AL
gene id: 9031:SLC51AL
uniprot id: E1BTD2
names: Subcellular Location Annotation
messages: Membrane

9031:OCM3
gene id: 9031:OCM3
uniprot id: P19753
names: Function
names: Miscellaneous
names: Similarity
messages: Appears to promote immune maturation in bone marrow cells in culture. Binds two calcium ions.
messages: Belongs to the parvalbumin family.
messages: This parvalbumin has an isoelectric point of 4.3.

9031:PPA1
gene id: 9031:PPA1
uniprot id: F1NT28
names: Similarity
messages: Belongs to the PPase family.

9031:CISH
gene id: 9031:CISH
uniprot id: Q9PW70
names: Domain
names: Function
messages: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

9031:SLC35E3
gene id: 9031:SLC35E3
uniprot id: F1NGX8
names: Subcellular Location Annotation
messages: Membrane

9031:FZD4
gene id: 9031:FZD4
uniprot id: Q9IA05
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Expressed in optic cup at stages 10-19 and in nephric tubules from stage 10 to 20 and more. Expression in interdigital space begins at stage 20.
messages: Expressed in the developing kidney, interdigital spaces and optic cup.
messages: Interacts (via FZ domain) with TSKU; TSKU competes with WNT2B for binding to FZD4, inhibiting Wnt signaling and repressing peripheral eye development.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase (By similarity). Both pathways seem to involve interactions with G-proteins (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity).
messages: The FZ domain is involved in binding with Wnt ligands.

9031:NSUN3
gene id: 9031:NSUN3
uniprot id: A0A1D5NWQ9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9031:SPRY1
gene id: 9031:SPRY1
uniprot id: A4LA71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

9031:ARC
gene id: 9031:ARC
uniprot id: Q8AWC3
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ARC/ARG3.1 family.
messages: By synaptic activity. Transcript level significantly increased in auditory cortex as well as two higher-associative brain regions by auditory imprinting stimulus in newborn chicks.
messages: Early endosome membrane
messages: Expressed at various levels throughout the brain.
messages: Extracellular vesicle membrane
messages: Homooligomer; homooligomerizes into virion-like capsids.
messages: Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material.
messages: Palmitoylation anchors the protein into the membrane by allowing direct insertion into the hydrophobic core of the lipid bilayer.
messages: Postsynaptic cell membrane
messages: Postsynaptic density
messages: Synapse
messages: The protein is evolutionarily related to retrotransposon Gag proteins: it contains large N- and C-terminal domains that form a bi-lobar architecture similar to the capsid domain of human immunodeficiency virus (HIV) gag protein. It contains structural elements found within viral Gag polyproteins originated from the Ty3/gypsy retrotransposon family and retains the ability to form virion-like capsid structures that can mediate mRNA transfer between cells. Tetrapod and fly Arc protein-coding genes originated independently from distinct lineages of Ty3/gypsy retrotransposons.
messages: cell cortex
messages: cytoskeleton
messages: dendrite
messages: dendritic spine

9031:DD1CR
gene id: 9031:DD1CR
uniprot id: B7U502
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:PCDHA7
gene id: 9031:PCDHA7
uniprot id: Q6R0I4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:GTF2A1
gene id: 9031:GTF2A1
uniprot id: A1IIE6
uniprot id: Q5F3E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

9031:DAG1
gene id: 9031:DAG1
uniprot id: A4VAR9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9031:PROK1
gene id: 9031:PROK1
uniprot id: A0A3Q2U6T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9031:PLA1A
gene id: 9031:PLA1A
uniprot id: F1NM35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9031:ITGAV
gene id: 9031:ITGAV
uniprot id: P26008
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin alpha chain family.
messages: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V (ITGAV) associates with either beta-1 (ITGB1), beta-3 (ITGB3), beta-5 (ITGB5), beta-6 (ITGB6) or beta-8 (ITGB8) (By similarity). Interacts with RAB25. Interacts with CIB1 (By similarity). Integrins ITGAV:ITGB3 and ITGAV:ITGB5 interact with FBLN5 (via N-terminus) (By similarity). ITGAV:ITGB3 and ITGAV:ITGB5 interact with CCN3 (By similarity). ITGAV:ITGB3 interacts with ADGRA2 (By similarity). ITGAV:ITGB3 interacts with FGF2; it is likely that FGF2 can simultaneously bind ITGAV:ITGB3 and FGF receptors (By similarity). ITGAV:ITGB3 is found in a ternary complex with CX3CR1 and CX3CL1. ITGAV:ITGB3 is found in a ternary complex with NRG1 and ERBB3. ITGAV:ITGB3 is found in a ternary complex with FGF1 and FGFR1. ITGAV:ITGB3 is found in a ternary complex with IGF1 and IGF1R (By similarity). ITGAV:ITGB3 interacts with IGF2 (By similarity). ITGAV:ITGB3 and ITGAV:ITGB6 interact with FBN1 (By similarity). ITGAV:ITGB3 interacts with CD9, CD81 and CD151 (via second extracellular domain) (By similarity). ITGAV:ITGB6 interacts with TGFB1 (By similarity).
messages: Membrane
messages: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). ITGAV:ITGB3 acts as a receptor for CD40LG (By similarity).
messages: focal adhesion

9031:CYP24A1
gene id: 9031:CYP24A1
uniprot id: O73684
names: Similarity
messages: Belongs to the cytochrome P450 family.

9031:SVIL
gene id: 9031:SVIL
uniprot id: A0A3Q2U6D7
uniprot id: A0A3Q3AIZ0
names: Similarity
messages: Belongs to the villin/gelsolin family.

9031:PPIL1
gene id: 9031:PPIL1
uniprot id: A0A1D5PW44
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9031:GPR137B
gene id: 9031:GPR137B
uniprot id: E1C7C7
uniprot id: Q5ZLT1
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9031:VPS29
gene id: 9031:VPS29
uniprot id: A0A1L1RIQ6
uniprot id: Q5ZIL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrins. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity).
messages: Belongs to the VPS29 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity). Component of the heterotrimeric retriever complex (By similarity).
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9031:HAAO
gene id: 9031:HAAO
uniprot id: E1C0L2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9031:ENO4
gene id: 9031:ENO4
uniprot id: A0A3Q3AEZ3
uniprot id: F1P5H2
names: Similarity
messages: Belongs to the enolase family.

9031:NUP155
gene id: 9031:NUP155
uniprot id: F1NPS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: nuclear pore complex

9031:DUSP4
gene id: 9031:DUSP4
uniprot id: Q9PW71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus
messages: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

9031:MED21
gene id: 9031:MED21
uniprot id: R4GGZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9031:RRM2
gene id: 9031:RRM2
uniprot id: E1BXP4
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

9031:VDAC3
gene id: 9031:VDAC3
uniprot id: A0A1L1RKA6
uniprot id: A0A1L1RZW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

9031:TDP2
gene id: 9031:TDP2
uniprot id: F1NW29
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily.
messages: Binds 1 magnesium or manganese ion per subunit.
messages: Can partially complement the absence of TDP1 due to its weak 3'-tyrosyl DNA phosphodiesterase activity.
messages: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (By similarity). Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1.
messages: Nucleus
messages: PML body

9031:RPS6KA6
gene id: 9031:RPS6KA6
uniprot id: E1C7L2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

9031:SLU7
gene id: 9031:SLU7
uniprot id: Q5ZIG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLU7 family.
messages: Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

9031:LOC100859414
gene id: 9031:LOC100859414
uniprot id: A0A3Q3AA10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

9031:PELO
gene id: 9031:PELO
uniprot id: Q5ZK01
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. Required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. Upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.
messages: Cytoplasm
messages: Nucleus
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

9031:MEIS2
gene id: 9031:MEIS2
uniprot id: F5ANJ3
uniprot id: F5ANJ4
uniprot id: Q9PTH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9031:MLEC
gene id: 9031:MLEC
uniprot id: F1N872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9031:OPNP
gene id: 9031:OPNP
uniprot id: A0A140T8G2
uniprot id: P51475
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Pineal gland.
messages: Produces a slow and prolonged phototransduction response consistent with the non-visual function of pineal photoreception.

9031:GLRB
gene id: 9031:GLRB
uniprot id: F1P037
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

9031:DCLRE1B
gene id: 9031:DCLRE1B
uniprot id: Q5QJC3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways (By similarity). May be required for DNA interstrand cross-link repair (PubMed:15572677). Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity).
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Interacts with TERF2; the interaction is direct.
messages: Nucleus
messages: The TBM domain mediates interaction with TERF2.
messages: telomere

9031:CCL5
gene id: 9031:CCL5
uniprot id: Q8QG57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9031:DMRTB1
gene id: 9031:DMRTB1
uniprot id: E9LHE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9031:PARL
gene id: 9031:PARL
uniprot id: F1NUI6
names: Subcellular Location Annotation
messages: Membrane

9031:MYL1
gene id: 9031:MYL1
uniprot id: P02604
uniprot id: P02605
names: PTM
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.
messages: The N-terminus is blocked.
messages: The N-terminus is blocked. N,N,N-trimethylalanine, found in other myosin light chains would not have been detected in the N-terminal tryptic peptide in PubMed:6709041 and PubMed:7238855 because it would remain trimethylated and ninhydrin negative after hydrolysis.

9031:PTPN3
gene id: 9031:PTPN3
uniprot id: F1NHM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

9031:ATF1
gene id: 9031:ATF1
uniprot id: A0A1D5PT06
uniprot id: A0A1L1RQX8
names: Subcellular Location Annotation
messages: Nucleus

9031:SEC24B
gene id: 9031:SEC24B
uniprot id: Q5ZM67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9031:AGA
gene id: 9031:AGA
uniprot id: Q5ZJG0
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9031:ST6GAL1
gene id: 9031:ST6GAL1
uniprot id: F1NRE4
uniprot id: Q92182
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Highly expressed in testis, brain and liver and to a lesser extent in lung and heart.
messages: Membrane
messages: Monomer and homodimer.
messages: N-glycosylated.
messages: Secreted
messages: The soluble form derives from the membrane form by proteolytic processing.
messages: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

9031:TRIO
gene id: 9031:TRIO
uniprot id: A0A1D5NZW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm

9031:FTH1
gene id: 9031:FTH1
uniprot id: P08267
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

9031:GSR
gene id: 9031:GSR
uniprot id: A0A1D5P338
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

9031:ZER1
gene id: 9031:ZER1
uniprot id: F1NI66
names: Similarity
messages: Belongs to the zyg-11 family.

9031:BCR
gene id: 9031:BCR
uniprot id: E1C0M5
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9031:AHR1A
gene id: 9031:AHR1A
uniprot id: F1NLX8
uniprot id: Q9I9E2
names: Subcellular Location Annotation
messages: Cytoplasm

9031:C1orf43
gene id: 9031:C1orf43
uniprot id: A0A1D5P7T4
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

9031:SULT1C3
gene id: 9031:SULT1C3
uniprot id: Q90WR6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9031:NOB1
gene id: 9031:NOB1
uniprot id: F1NRU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

9031:CEP162
gene id: 9031:CEP162
uniprot id: A0A3Q2U7K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

9031:CDH4
gene id: 9031:CDH4
uniprot id: A0A3Q3ACG0
uniprot id: P24503
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
messages: Cell membrane
messages: Detected only after some degree of neuronal differentiation has taken place and persists at least up to the newly hatched stage.
messages: Embryonic brain and neuronal retina.
messages: Membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:SDC4
gene id: 9031:SDC4
uniprot id: P49416
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
messages: Interacts with SDOS.
messages: Membrane

9031:GDE1
gene id: 9031:GDE1
uniprot id: A0A1D5PNJ4
uniprot id: F1P2N8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9031:RNMT
gene id: 9031:RNMT
uniprot id: E1BYM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9031:GFM2
gene id: 9031:GFM2
uniprot id: E1C430
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9031:FGF9
gene id: 9031:FGF9
uniprot id: Q7ZZN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

9031:ERBB4
gene id: 9031:ERBB4
uniprot id: Q4PLA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

9031:PLAC8L1
gene id: 9031:PLAC8L1
uniprot id: F1NUW2
names: Similarity
messages: Belongs to the cornifelin family.

9031:FSIP1
gene id: 9031:FSIP1
uniprot id: E1C166
names: Similarity
messages: Belongs to the FSIP1 family.

9031:ARF6
gene id: 9031:ARF6
uniprot id: P26990
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity).
messages: In 3 days embryos.
messages: Midbody ring
messages: Recycling endosome membrane
messages: cytosol
messages: filopodium membrane
messages: ruffle

9031:GJB5
gene id: 9031:GJB5
uniprot id: A0A3Q2U3Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9031:BTF3L4
gene id: 9031:BTF3L4
uniprot id: Q5ZJG3
names: Similarity
messages: Belongs to the NAC-beta family.

9031:BRD7
gene id: 9031:BRD7
uniprot id: Q5ZKG2
names: Function
names: Subcellular Location Annotation
messages: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Participates in the Wnt signaling pathway. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Inhibits cell cycle progression from G1 to S phase (By similarity).
messages: Nucleus

9031:ACTC1
gene id: 9031:ACTC1
uniprot id: P68034
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

9031:IL18
gene id: 9031:IL18
uniprot id: Q9I8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Secreted

9031:ARL8A
gene id: 9031:ARL8A
uniprot id: Q5ZKQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity).
messages: Synapse
messages: axon
messages: spindle

9031:SEMA3D
gene id: 9031:SEMA3D
uniprot id: Q90663
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Developing spinal cord and developing visual system. Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.
messages: Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin.
messages: Secreted
messages: Strong binding to neuropilin is mediated by the carboxy third of the protein.

9031:F10
gene id: 9031:F10
uniprot id: P25155
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. VAP cleaves the fusion proteins of Sendai virus, NDV, and influenza virus a at a specific single arginine-containing site, and plays a key role in the viral spreading in the allantoic sac.
messages: Liver and chorioallantoic membrane.
messages: Secreted
messages: The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
messages: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds.
messages: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.

9031:BMP5
gene id: 9031:BMP5
uniprot id: P87373
names: Similarity
messages: Belongs to the TGF-beta family.

9031:PHF10
gene id: 9031:PHF10
uniprot id: A0A1D5NX83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

9031:LASP1
gene id: 9031:LASP1
uniprot id: D2Z1L9
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9031:TSPAN17
gene id: 9031:TSPAN17
uniprot id: F1NIA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9031:GPX7
gene id: 9031:GPX7
uniprot id: E1C697
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9031:HYAL6
gene id: 9031:HYAL6
uniprot id: F1NFN8
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9031:DCSTAMP
gene id: 9031:DCSTAMP
uniprot id: A0A1D5PJ70
names: Subcellular Location Annotation
messages: Membrane

9031:TM9SF2L
gene id: 9031:TM9SF2L
uniprot id: Q5ZLM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9031:RORB
gene id: 9031:RORB
uniprot id: Q98934
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9031:SLC6A9
gene id: 9031:SLC6A9
uniprot id: Q5ZL10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9031:ST3GAL6
gene id: 9031:ST3GAL6
uniprot id: F1NQP1
uniprot id: Q70D52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9031:HBP1
gene id: 9031:HBP1
uniprot id: E1C2B1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9031:SNRPC
gene id: 9031:SNRPC
uniprot id: A0A1I7Q3Y9
uniprot id: E1C6F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

9031:FUT11
gene id: 9031:FUT11
uniprot id: Q8AWC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Probable fucosyltransferase.

9031:PHPT1
gene id: 9031:PHPT1
uniprot id: A0A1D5PWG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the janus family.
messages: Cytoplasm
messages: Exhibits phosphohistidine phosphatase activity.
messages: Monomer.

9031:MSH6
gene id: 9031:MSH6
uniprot id: A0A1I7Q445
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

9031:TMEM267
gene id: 9031:TMEM267
uniprot id: A0A1L1RL63
names: Subcellular Location Annotation
messages: Membrane

9031:LPP
gene id: 9031:LPP
uniprot id: Q5F464
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zyxin/ajuba family.
messages: Cell junction
messages: Cytoplasm
messages: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. May be involved in signal transduction from cell adhesion sites to the nucleus (By similarity).
messages: Nucleus

9031:LDB3
gene id: 9031:LDB3
uniprot id: A0A1D5P909
names: Subcellular Location Annotation
messages: Z line

9031:ATE1
gene id: 9031:ATE1
uniprot id: A0A3Q2TZK1
uniprot id: Q5F446
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

9031:GGH
gene id: 9031:GGH
uniprot id: A0A1D5P167
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: extracellular space

9031:AvBD8
gene id: 9031:AvBD8
uniprot id: Q6IV23
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the beta-defensin family.
messages: Cytoplasmic granule
messages: Detected in the theca and granulosa layers of the ovarian follicle in the white follicle (WF), F1, F3, F5, and postovulatory follicle stages.
messages: Expressed in the liver, kidney, gall bladder, testis, ovary and male and femae reproductive tracts. Expressed in the ovarian stroma and the theca and granulosa layers of the ovarian follicle.
messages: Has bactericidal activity.
messages: Induced in the theca layer of the F3 stage ovarian follicle by intravenous injection of LPS. Expression in the granulosa layer of the ovarian follicle is not affected by intravenous injection of LPS.
messages: Secreted

9031:SLC34A1
gene id: 9031:SLC34A1
uniprot id: A0A1D5NWQ4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9031:RAX2
gene id: 9031:RAX2
uniprot id: Q9PVY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus
messages: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.

9031:SNX2
gene id: 9031:SNX2
uniprot id: Q5F406
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

9031:PROM2
gene id: 9031:PROM2
uniprot id: A0A1D5PPW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9031:SLC5A11
gene id: 9031:SLC5A11
uniprot id: A0A3Q2U0A6
uniprot id: E1C8N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

9031:EBF1
gene id: 9031:EBF1
uniprot id: A0A1D5NYJ1
uniprot id: F1N9Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9031:VMO1
gene id: 9031:VMO1
uniprot id: P41366
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMO1 family.
messages: Exact function not known, component of the outer membrane of the vitelline layer of the egg. Seems to be able to synthesize N-acetylchito-oligosaccharides (n=14-15) from hexasaccharides of N-acetylglucosamine in a manner similar to the transferase activity of lysozyme.
messages: Secreted

9031:ARPP19
gene id: 9031:ARPP19
uniprot id: Q5ZLY8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Interacts (when phosphorylated at Ser-62) with PPP2R2D.
messages: Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A.
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).

9031:AVD
gene id: 9031:AVD
uniprot id: P02701
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the avidin/streptavidin family.
messages: Homotetramer.
messages: N-linked glycan at Asn-41 consists of GlcNAc(beta1-2)Man(alpha1-3)[GlcNAc(beta1-4)][Man(alpha1-?)Man(alpha1-6)] Man(beta1-4)GlcNAc(beta1-4)GlcNAc.
messages: Secreted
messages: Synthesized in hen oviduct and concentrated in egg white (where it represents 0.05% of the total protein).
messages: The biological function of avidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of avidin).

9031:NRP1
gene id: 9031:NRP1
uniprot id: P79795
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the neuropilin family.
messages: Cell membrane
messages: Developing nervous system; optic tectum (layers D and E of SGFS), amacrine cells of retina, neurites of dorsal root ganglia. Also expressed in non-neuronal cells, e.g. blood vessels in the entire embryo.
messages: Homodimer, and heterodimer.
messages: Mitochondrion membrane
messages: Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction (By similarity).

9031:COL6A1
gene id: 9031:COL6A1
uniprot id: P20785
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type VI collagen family.
messages: Collagen VI acts as a cell-binding protein.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: Trimers composed of three different chains: alpha 1(VI), alpha 2(VI), and alpha 3(VI).
messages: extracellular matrix

9031:TMC6
gene id: 9031:TMC6
uniprot id: A0A1D5P3F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9031:B4GALT1
gene id: 9031:B4GALT1
uniprot id: Q92074
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9031:SEC31A
gene id: 9031:SEC31A
uniprot id: A0A1D5P9Q7
uniprot id: A0A3Q2TXN7
uniprot id: A0A3Q2UED1
uniprot id: A0A3Q2UK47
uniprot id: A0A3Q3AQV2
uniprot id: Q5F3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC31 family.
messages: COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity).
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane

9031:COMP
gene id: 9031:COMP
uniprot id: A0A3Q2UFV6
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:KIF11
gene id: 9031:KIF11
uniprot id: Q5ZMS0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:NKX2-1
gene id: 9031:NKX2-1
uniprot id: A0A1D5PQG0
uniprot id: Q9YH59
names: Subcellular Location Annotation
messages: Nucleus

9031:NF2L
gene id: 9031:NF2L
uniprot id: A0A3Q3AT45
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

9031:TNFSF15
gene id: 9031:TNFSF15
uniprot id: Q50L61
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9031:DGCR6
gene id: 9031:DGCR6
uniprot id: O73770
names: Similarity
messages: Belongs to the gonadal family.

9031:DYNC1H1
gene id: 9031:DYNC1H1
uniprot id: F1NKL4
names: Similarity
messages: Belongs to the dynein heavy chain family.

9031:GSN
gene id: 9031:GSN
uniprot id: O93510
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the villin/gelsolin family.
messages: Binds to actin and to fibronectin.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity).
messages: Comprises six structurally related gelsolin-like (G1-G6) domains, that, in a calcium-free environment, are packed together to form a compact globular structure in which the putative actin-binding sequences are not sufficiently exposed to enable binding to occur. Binding calcium may release the connections that join the N- and C-terminal halves of gelsolin, enabling each half to bind actin relatively independently. G1 and G4 bind two Ca(2+) in a type I and in a type II manner. G2, G3, G5 and G6 bind only one Ca(2+) in a type II manner. Type I Ca(2+) binding sites are shared between actin and gelsolin-like repeats G1 and G4. Type I binding governs the strength of interactions between gelsolin and actin by direct participation at the binding interface. Ca(2+) binding to G2 and G6 disrupts the interactions between G2 and G6, releases the C-terminal tail, and induces large interdomain rearrangements that result in the exposure of the F-actin-binding site on G2 and contributes to the activation of gelsolin. Binding to phosphoinositides may inhibit the severing and capping properties of gelsolin.
messages: Highly expressed in homogene cells of the basilar papilla. Also detected in subcutaneous layer of the skin.
messages: Secreted
messages: cytoskeleton

9031:TBL1X
gene id: 9031:TBL1X
uniprot id: A0A1D5PXG9
names: Similarity
messages: Belongs to the WD repeat EBI family.

9031:HAO1
gene id: 9031:HAO1
uniprot id: E1BRR7
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

9031:KCNG3
gene id: 9031:KCNG3
uniprot id: E1C0L8
names: Subcellular Location Annotation
messages: Membrane

9031:ABCC9
gene id: 9031:ABCC9
uniprot id: A0A1D5P453
uniprot id: A0A1D5PIV1
uniprot id: E1BZE8
names: Subunit
messages: Interacts with KCNJ11.

9031:ACAT1
gene id: 9031:ACAT1
uniprot id: E1C0Q5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9031:PLCB4
gene id: 9031:PLCB4
uniprot id: A0A3Q2U0G2
uniprot id: A0A3Q3AX15
uniprot id: R4GFB3
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9031:ACADS
gene id: 9031:ACADS
uniprot id: Q5ZL56
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9031:MTERF3
gene id: 9031:MTERF3
uniprot id: Q5ZJC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mTERF family.
messages: Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity).
messages: Contains about seven structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a superhelical structure with a solenoid shape (By similarity).
messages: Mitochondrion

9031:AGMAT
gene id: 9031:AGMAT
uniprot id: Q90XD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginase family. Agmatinase subfamily.
messages: Mitochondrion

9031:SLC22A18
gene id: 9031:SLC22A18
uniprot id: E1BQC0
names: Subcellular Location Annotation
messages: Membrane

9031:LMOD2
gene id: 9031:LMOD2
uniprot id: E1BTG2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomodulin family.
messages: Can bind at least three actin monomers and thereby provides a nucleus for actin filament formation. Interacts (via N-terminus) with tropomyosin alpha (TPM1) (via N-terminus). May also interact with TPM2 (via N-terminus).
messages: First detected in myocardium at HH stage 14. Detected in myocardium and somites at HH stage 17 and 19.
messages: M line
messages: Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length (PubMed:20736303). Required for normal sarcomere organization in the heart, and for normal heart function (By similarity).
messages: cytoskeleton
messages: myofibril
messages: sarcomere

9031:MEF2A
gene id: 9031:MEF2A
uniprot id: A0A1D5PBY4
uniprot id: A0A3Q2UIF7
names: Subcellular Location Annotation
messages: Nucleus

9031:UBN1
gene id: 9031:UBN1
uniprot id: A0A1D5P9Y4
names: Similarity
messages: Belongs to the ubinuclein family.

9031:FABP5
gene id: 9031:FABP5
uniprot id: Q5ZIR7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

9031:SH3RF1
gene id: 9031:SH3RF1
uniprot id: F1NYR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

9031:SDHD
gene id: 9031:SDHD
uniprot id: Q5ZIS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9031:HSPH1
gene id: 9031:HSPH1
uniprot id: E1BT08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9031:HSCB
gene id: 9031:HSCB
uniprot id: F1N857
names: Similarity
messages: Belongs to the HscB family.

9031:MRPL50
gene id: 9031:MRPL50
uniprot id: Q5ZLC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

9031:SIK1
gene id: 9031:SIK1
uniprot id: Q9IA88
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by phosphorylation on Thr-181.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: Phosphorylated at Thr-181 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
messages: Phosphorylates IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity).
messages: Ubiquitously expressed in embryonic tissue.

9031:COL6A2
gene id: 9031:COL6A2
uniprot id: P15988
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type VI collagen family.
messages: Collagen VI acts as a cell-binding protein.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: Trimers composed of three different chains: alpha 1(VI), alpha 2(VI), and alpha 3(VI).
messages: extracellular matrix

9031:OTX2
gene id: 9031:OTX2
uniprot id: Q6E236
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9031:RPS20
gene id: 9031:RPS20
uniprot id: F1NH93
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

9031:UPP2
gene id: 9031:UPP2
uniprot id: A0A1L1RSG3
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9031:LOC416924
gene id: 9031:LOC416924
uniprot id: A0A1D5PFZ0
names: Similarity
messages: Belongs to the THADA family.

9031:SSTR4
gene id: 9031:SSTR4
uniprot id: Q4PLA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:SDHA
gene id: 9031:SDHA
uniprot id: F1NPJ4
uniprot id: Q9YHT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9031:MCM8
gene id: 9031:MCM8
uniprot id: I0IUP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MCM family.
messages: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.
messages: Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9.
messages: Nucleus

9031:KIF9
gene id: 9031:KIF9
uniprot id: E1C427
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:CYP17A1
gene id: 9031:CYP17A1
uniprot id: P12394
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.
messages: Membrane

9031:CDH11
gene id: 9031:CDH11
uniprot id: O93319
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration.
messages: Cell membrane
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

9031:NFIA
gene id: 9031:NFIA
uniprot id: Q90925
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9031:OR52L1
gene id: 9031:OR52L1
uniprot id: R4GIA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9031:DESI1
gene id: 9031:DESI1
uniprot id: A0A3Q3B0Z9
names: Similarity
messages: Belongs to the DeSI family.

9031:POMT1
gene id: 9031:POMT1
uniprot id: F1NMM0
uniprot id: Q5ZK29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9031:MAMDC4
gene id: 9031:MAMDC4
uniprot id: A0A3Q2U8Q1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:TPD52L2
gene id: 9031:TPD52L2
uniprot id: Q5ZI93
names: Similarity
messages: Belongs to the TPD52 family.

9031:FGGY
gene id: 9031:FGGY
uniprot id: E1C771
names: Similarity
messages: Belongs to the FGGY kinase family.

9031:CSNK1G1
gene id: 9031:CSNK1G1
uniprot id: A0A3Q3AWM4
uniprot id: Q5ZJS0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
messages: Cytoplasm

9031:IDH3A
gene id: 9031:IDH3A
uniprot id: A0A1L1RX65
uniprot id: Q5ZI29
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9031:TSHR
gene id: 9031:TSHR
uniprot id: Q3V5L9
uniprot id: Q3V5M0
uniprot id: Q3V5M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

9031:DDX27
gene id: 9031:DDX27
uniprot id: Q5ZLD0
names: Similarity
messages: Belongs to the DEAD box helicase family.

9031:CAPN13
gene id: 9031:CAPN13
uniprot id: E1BRR5
names: Similarity
messages: Belongs to the peptidase C2 family.

9031:RFC1
gene id: 9031:RFC1
uniprot id: Q5ZKU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

9031:FGF2
gene id: 9031:FGF2
uniprot id: P48800
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity).
messages: Belongs to the heparin-binding growth factors family.
messages: Nucleus
messages: Secreted

9031:POLR2L
gene id: 9031:POLR2L
uniprot id: E1BSY6
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

9031:EMG1
gene id: 9031:EMG1
uniprot id: F1N832
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

9031:MARCKSL1
gene id: 9031:MARCKSL1
uniprot id: Q5ZKS0
names: Similarity
messages: Belongs to the MARCKS family.

9031:CLDN19
gene id: 9031:CLDN19
uniprot id: A0A3Q3A4L0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9031:GNG12
gene id: 9031:GNG12
uniprot id: R4GFT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9031:ADCY3
gene id: 9031:ADCY3
uniprot id: F1NGF1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9031:RBM15
gene id: 9031:RBM15
uniprot id: F1NRZ4
names: Similarity
messages: Belongs to the RRM Spen family.

9031:S100B
gene id: 9031:S100B
uniprot id: E1C251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

9031:MT4
gene id: 9031:MT4
uniprot id: P68497
names: Domain
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9031:ASL
gene id: 9031:ASL
uniprot id: P05083
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase.
messages: Eye lens.
messages: Homotetramer.
messages: It is uncertain if this gene is expressed.

9031:TBX4
gene id: 9031:TBX4
uniprot id: O93288
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:UBLCP1
gene id: 9031:UBLCP1
uniprot id: Q5ZJJ8
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).
messages: Nucleus
messages: The Ubiquitin-like domain mediates interaction with proteasomes.

9031:ING5
gene id: 9031:ING5
uniprot id: Q5ZHX3
uniprot id: Q5ZJ84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9031:CL2
gene id: 9031:CL2
uniprot id: Q5GAL6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

9031:SLC43A2
gene id: 9031:SLC43A2
uniprot id: E1C4M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
messages: Membrane

9031:CALB1
gene id: 9031:CALB1
uniprot id: P04354
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Highly abundant in supporting cells. Also present in hair cells.
messages: This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

9031:CRYGN
gene id: 9031:CRYGN
uniprot id: D0FH75
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

9031:LYAR
gene id: 9031:LYAR
uniprot id: E1C1Q0
names: Subcellular Location Annotation
messages: Cytoplasm

9031:C20H20ORF24
gene id: 9031:C20H20ORF24
uniprot id: Q5ZMJ3
names: Subcellular Location Annotation
messages: Membrane

9031:SLCO1A2
gene id: 9031:SLCO1A2
uniprot id: A0A1D5PMA0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:PLPPR4
gene id: 9031:PLPPR4
uniprot id: R4GL67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9031:PKNOX1
gene id: 9031:PKNOX1
uniprot id: E1BYI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9031:TMEM132E
gene id: 9031:TMEM132E
uniprot id: F1P195
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9031:B3GALT2
gene id: 9031:B3GALT2
uniprot id: A0A3Q2TVW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9031:DDX52
gene id: 9031:DDX52
uniprot id: Q5F3Y6
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.

9031:CPSF6
gene id: 9031:CPSF6
uniprot id: A0A1D5P9A5
uniprot id: F1NGU9
uniprot id: Q5ZL34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM CPSF6/7 family.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. Plays a role in mRNA export.
messages: Component of the cleavage factor Im (CFIm) complex.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: nucleoplasm

9031:TIMM13
gene id: 9031:TIMM13
uniprot id: R4GGQ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9031:ALKBH8
gene id: 9031:ALKBH8
uniprot id: A0A1D5P2W9
uniprot id: A0A3Q2TTL6
uniprot id: A0A3Q3B0E1
uniprot id: F1P0F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

9031:GAL3ST1
gene id: 9031:GAL3ST1
uniprot id: F1NP56
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9031:HOXD12
gene id: 9031:HOXD12
uniprot id: P24343
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Abd-B homeobox family.
messages: Coordinately expressed in partially overlapping domains during wing development.
messages: Expressed primarily in limb buds.
messages: Interacts with MAF and MAFB.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9031:IRF9
gene id: 9031:IRF9
uniprot id: Q90WI0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9031:ESD
gene id: 9031:ESD
uniprot id: E1BXC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9031:CR1
gene id: 9031:CR1
uniprot id: F1NE59
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9031:MAP7
gene id: 9031:MAP7
uniprot id: Q5ZIA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAP7 family.
messages: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells.
messages: cytoskeleton
messages: perinuclear region

9031:SLC16A7
gene id: 9031:SLC16A7
uniprot id: F1NVU4
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

9031:MFAP3
gene id: 9031:MFAP3
uniprot id: F1NWZ4
uniprot id: Q5F3V6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9031:TMEM165
gene id: 9031:TMEM165
uniprot id: A0A1L1RXM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

9031:SYNJ1
gene id: 9031:SYNJ1
uniprot id: A0A1D5NT69
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9031:XKR9
gene id: 9031:XKR9
uniprot id: Q49M59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9031:STEEP1
gene id: 9031:STEEP1
uniprot id: E1BYZ0
names: Similarity
messages: Belongs to the STEEP1 family.

9031:ATP5C1
gene id: 9031:ATP5C1
uniprot id: A0A1D5P0U8
uniprot id: A0A1L1RYK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9031:RPLP1
gene id: 9031:RPLP1
uniprot id: P18660
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

9031:MYO9B
gene id: 9031:MYO9B
uniprot id: A0A1D5P2Q0
uniprot id: A0A1D5PTR8
uniprot id: A0A1D5PYC5
uniprot id: E1C470
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:PLTP
gene id: 9031:PLTP
uniprot id: C5H3Z3
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

9031:DHRS11
gene id: 9031:DHRS11
uniprot id: Q71R50
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
messages: Inhibited by flavonoids including apigenin, luteolin, genistein, kaempferol and quercetin and also by carbenoxolone, zearalenone, glycyrrhetinic, curcumin and flufenamic acid.
messages: Secreted

9031:TF
gene id: 9031:TF
uniprot id: P02789
names: Allergen
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Causes an allergic reaction in human.
messages: Different forms of hen transferrin are distinguished by their carbohydrate composition. Ovotransferrin and embryo serum transferrin but not adult serum transferrin, have bisecting N-acetylglucosamine. Transferrin secreted by embryo hepatocytes in primary culture is marked by the presence of (alpha1-6) fucosylation of the core N-acetylglucosamine. Serum transferrins also differ in the number of attached neuraminic acid residues. In both embryo forms, sialylation occurs on the Man (alpha 1-3)-linked antennae.
messages: Expressed in the magnum of the oviduct (at protein level).
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels.
messages: Up-regulated by dietary stress. Increased expression at day 14 in the magnum of the oviduct in the corticosterone-fed laying hens (at protein level).

9031:ARSH
gene id: 9031:ARSH
uniprot id: Q71BV1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9031:XRN2
gene id: 9031:XRN2
uniprot id: Q5ZIP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II (By similarity).
messages: nucleolus

9031:ART1L3
gene id: 9031:ART1L3
uniprot id: P55807
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.
messages: extracellular space

9031:SEPHS1
gene id: 9031:SEPHS1
uniprot id: F1N876
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9031:KLHL15
gene id: 9031:KLHL15
uniprot id: A0A1D5PIX2
uniprot id: F1NNV8
uniprot id: Q5ZJU2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer. Interacts with CUL3.
messages: Nucleus
messages: Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex.

9031:NOC4L
gene id: 9031:NOC4L
uniprot id: Q5ZJC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane
messages: nucleolus

9031:TMEM255B
gene id: 9031:TMEM255B
uniprot id: A0A1D5PFG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

9031:ZDHHC23
gene id: 9031:ZDHHC23
uniprot id: Q5F493
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9031:MTX3
gene id: 9031:MTX3
uniprot id: Q5F3K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9031:MYO1E
gene id: 9031:MYO1E
uniprot id: F1P4D9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9031:SLC25A12
gene id: 9031:SLC25A12
uniprot id: A0A1D5PP62
uniprot id: A0A1D5PSJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9031:THBS4
gene id: 9031:THBS4
uniprot id: F1NBP0
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:KIFC2
gene id: 9031:KIFC2
uniprot id: A0A1D5PZ94
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9031:OLFML2A
gene id: 9031:OLFML2A
uniprot id: F1P0X8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9031:POLR1C
gene id: 9031:POLR1C
uniprot id: A0A1D5PP80
uniprot id: A0A1L1RS34
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

9031:NOL11
gene id: 9031:NOL11
uniprot id: Q5ZL79
names: Function
names: Subcellular Location Annotation
messages: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and pre-rRNA processing (By similarity).
messages: nucleolus

9031:GRP
gene id: 9031:GRP
uniprot id: A0A1D5PXC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: secretory vesicle lumen

9031:ABCC8
gene id: 9031:ABCC8
uniprot id: E1C949
names: Subunit
messages: Interacts with KCNJ11.

9031:PADI3
gene id: 9031:PADI3
uniprot id: F1NP39
uniprot id: O57400
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9031:ITGA6
gene id: 9031:ITGA6
uniprot id: P26007
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha-6 levels decrease with age.
messages: Belongs to the integrin alpha chain family.
messages: Cell membrane
messages: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 (ITGB1) or beta-4 (ITGB4) to form ITGA6:ITGB1 and ITGA6:ITGB4, respectively.
messages: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
messages: Phosphorylated in vivo.

9031:TADA2A
gene id: 9031:TADA2A
uniprot id: F1P5V3
names: Subcellular Location Annotation
messages: Nucleus

9031:PRNP
gene id: 9031:PRNP
uniprot id: P27177
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the prion family.
messages: Cell membrane
messages: Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
messages: Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.
messages: Spinal cord and brain.

9031:PDP1
gene id: 9031:PDP1
uniprot id: A0A1D5PGH3
uniprot id: A0A3Q2UF31
names: Similarity
messages: Belongs to the PP2C family.

9031:NDUFS7
gene id: 9031:NDUFS7
uniprot id: F1NYM3
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

9031:TSPAN3
gene id: 9031:TSPAN3
uniprot id: A0A1D5P279
uniprot id: E1C6E5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9031:SPON1
gene id: 9031:SPON1
uniprot id: Q9W770
names: Function
names: Subcellular Location Annotation
messages: Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Somite-derived spondin 1 is an inhibitory signal involved in patterning the segmental migration of neural crest cells and their topographical segregation within the rostral somites in vitro. May be required to prevent the lateral drifting of the commissural axons after having crossed the floor plate.
messages: extracellular matrix

9031:IKBKB
gene id: 9031:IKBKB
uniprot id: Q5ZI83
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9031:TRMT10C
gene id: 9031:TRMT10C
uniprot id: F1NMQ4
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9031:LOC100858506
gene id: 9031:LOC100858506
uniprot id: B0FLN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted