880724:METIG RS02200
gene id: 880724:METIG_RS02200
uniprot id: F6BBJ5
names: Similarity
messages: Belongs to the UPF0285 family.

880724:METIG RS01455
gene id: 880724:METIG_RS01455
uniprot id: F6BAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

880724:METIG RS02590
gene id: 880724:METIG_RS02590
uniprot id: F6BC01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

880724:METIG RS05125
gene id: 880724:METIG_RS05125
uniprot id: F6BDK6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

880724:METIG RS06640
gene id: 880724:METIG_RS06640
uniprot id: F6BER0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

880724:METIG RS04915
gene id: 880724:METIG_RS04915
uniprot id: F6BDH1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

880724:METIG RS06505
gene id: 880724:METIG_RS06505
uniprot id: F6BEN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

880724:METIG RS00225
gene id: 880724:METIG_RS00225
uniprot id: F6BEE5
names: Similarity
messages: Belongs to the UPF0201 family.

880724:METIG RS03015
gene id: 880724:METIG_RS03015
uniprot id: F6BCF3
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

880724:METIG RS04195
gene id: 880724:METIG_RS04195
uniprot id: F6BD33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

880724:METIG RS05390
gene id: 880724:METIG_RS05390
uniprot id: F6BDQ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

880724:METIG RS01695
gene id: 880724:METIG_RS01695
uniprot id: F6BAT7
names: Similarity
messages: Belongs to the UPF0284 family.

880724:METIG RS01630
gene id: 880724:METIG_RS01630
uniprot id: F6BAS4
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

880724:METIG RS04445
gene id: 880724:METIG_RS04445
uniprot id: F6BD78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

880724:METIG RS05715
gene id: 880724:METIG_RS05715
uniprot id: F6BDW8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

880724:METIG RS04985
gene id: 880724:METIG_RS04985
uniprot id: F6BDI4
names: Similarity
messages: Belongs to the peptidase C56 family.

880724:METIG RS08865
gene id: 880724:METIG_RS08865
uniprot id: F6BC88
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

880724:METIG RS02070
gene id: 880724:METIG_RS02070
uniprot id: F6BB94
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

880724:METIG RS04340
gene id: 880724:METIG_RS04340
uniprot id: F6BD58
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS06260
gene id: 880724:METIG_RS06260
uniprot id: F6BEA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

880724:METIG RS06800
gene id: 880724:METIG_RS06800
uniprot id: F6BET9
names: Similarity
messages: Belongs to the UPF0212 family.

880724:METIG RS04645
gene id: 880724:METIG_RS04645
uniprot id: F6BDB6
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS03495
gene id: 880724:METIG_RS03495
uniprot id: F6BCP9
names: Similarity
messages: Belongs to the UPF0280 family.

880724:METIG RS02115
gene id: 880724:METIG_RS02115
uniprot id: F6BBA3
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

880724:METIG RS06050
gene id: 880724:METIG_RS06050
uniprot id: F6BE65
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

880724:METIG RS00510
gene id: 880724:METIG_RS00510
uniprot id: F6BEK2
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

880724:METIG RS04280
gene id: 880724:METIG_RS04280
uniprot id: F6BD48
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

880724:METIG RS02630
gene id: 880724:METIG_RS02630
uniprot id: F6BC09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

880724:METIG RS03785
gene id: 880724:METIG_RS03785
uniprot id: F6BCV2
names: Similarity
names: Subunit
messages: Belongs to the L-cysteine desulfidase family.
messages: Homotrimer.

880724:METIG RS00360
gene id: 880724:METIG_RS00360
uniprot id: F6BEH2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

880724:METIG RS02905
gene id: 880724:METIG_RS02905
uniprot id: F6BCD3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

880724:METIG RS09025
gene id: 880724:METIG_RS09025
uniprot id: F6BCB9
names: Similarity
messages: Belongs to the FrhG family.

880724:METIG RS07740
gene id: 880724:METIG_RS07740
uniprot id: F6BAX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

880724:METIG RS08340
gene id: 880724:METIG_RS08340
uniprot id: F6BBQ8
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

880724:METIG RS07090
gene id: 880724:METIG_RS07090
uniprot id: F6BF65
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS04485
gene id: 880724:METIG_RS04485
uniprot id: F6BD86
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS02410
gene id: 880724:METIG_RS02410
uniprot id: F6BBN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

880724:METIG RS04395
gene id: 880724:METIG_RS04395
uniprot id: F6BD68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

880724:METIG RS05170
gene id: 880724:METIG_RS05170
uniprot id: F6BDL5
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

880724:METIG RS05950
gene id: 880724:METIG_RS05950
uniprot id: F6BE11
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS00400
gene id: 880724:METIG_RS00400
uniprot id: F6BEI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

880724:METIG RS03970
gene id: 880724:METIG_RS03970
uniprot id: F6BCY8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

880724:METIG RS06065
gene id: 880724:METIG_RS06065
uniprot id: F6BE68
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-107 inactivates the nitrogenase reductase and regulates nitrogenase activity.

880724:METIG RS04665
gene id: 880724:METIG_RS04665
uniprot id: F6BDC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

880724:METIG RS00160
gene id: 880724:METIG_RS00160
uniprot id: F6BE57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

880724:METIG RS07575
gene id: 880724:METIG_RS07575
uniprot id: F6BAU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

880724:METIG RS00790
gene id: 880724:METIG_RS00790
uniprot id: F6BEY2
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS00785
gene id: 880724:METIG_RS00785
uniprot id: F6BEY1
names: Similarity
messages: Belongs to the DtxR/MntR family.

880724:METIG RS02335
gene id: 880724:METIG_RS02335
uniprot id: F6BBM3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

880724:METIG RS04790
gene id: 880724:METIG_RS04790
uniprot id: F6BDE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

880724:METIG RS03985
gene id: 880724:METIG_RS03985
uniprot id: F6BCZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

880724:METIG RS02795
gene id: 880724:METIG_RS02795
uniprot id: F6BC41
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

880724:METIG RS09045
gene id: 880724:METIG_RS09045
uniprot id: F6BCC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

880724:METIG RS07315
gene id: 880724:METIG_RS07315
uniprot id: F6BAG8
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

880724:METIG RS03540
gene id: 880724:METIG_RS03540
uniprot id: F6BCQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

880724:METIG RS05705
gene id: 880724:METIG_RS05705
uniprot id: F6BDW6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

880724:METIG RS08815
gene id: 880724:METIG_RS08815
uniprot id: F6BC78
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

880724:METIG RS05735
gene id: 880724:METIG_RS05735
uniprot id: F6BDX2
names: Similarity
messages: Belongs to the MCM family.

880724:METIG RS03070
gene id: 880724:METIG_RS03070
uniprot id: F6BCG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

880724:METIG RS06210
gene id: 880724:METIG_RS06210
uniprot id: F6BE93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

880724:METIG RS07305
gene id: 880724:METIG_RS07305
uniprot id: F6BAG6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

880724:METIG RS08230
gene id: 880724:METIG_RS08230
uniprot id: F6BBF9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS07785
gene id: 880724:METIG_RS07785
uniprot id: F6BAY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

880724:METIG RS00325
gene id: 880724:METIG_RS00325
uniprot id: F6BEG5
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

880724:METIG RS04925
gene id: 880724:METIG_RS04925
uniprot id: F6BDH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

880724:METIG RS04065
gene id: 880724:METIG_RS04065
uniprot id: F6BD08
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

880724:METIG RS05970
gene id: 880724:METIG_RS05970
uniprot id: F6BE15
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

880724:METIG RS00695
gene id: 880724:METIG_RS00695
uniprot id: F6BEW5
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS04695
gene id: 880724:METIG_RS04695
uniprot id: F6BDC6
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

880724:METIG RS04100
gene id: 880724:METIG_RS04100
uniprot id: F6BD15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

880724:METIG RS09125
gene id: 880724:METIG_RS09125
uniprot id: F6BBB1
names: Similarity
messages: Belongs to the LEA type 2 family.

880724:METIG RS00945
gene id: 880724:METIG_RS00945
uniprot id: F6BF13
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

880724:METIG RS04700
gene id: 880724:METIG_RS04700
uniprot id: F6BDC7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

880724:METIG RS07490
gene id: 880724:METIG_RS07490
uniprot id: F6BAK2
names: Similarity
messages: Belongs to the AAA ATPase family.

880724:METIG RS00395
gene id: 880724:METIG_RS00395
uniprot id: F6BEH9
names: Similarity
messages: Belongs to the UPF0166 family.

880724:METIG RS05865
gene id: 880724:METIG_RS05865
uniprot id: F6BDZ3
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

880724:METIG RS09005
gene id: 880724:METIG_RS09005
uniprot id: F6BCB5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS03100
gene id: 880724:METIG_RS03100
uniprot id: F6BCG9
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

880724:METIG RS01250
gene id: 880724:METIG_RS01250
uniprot id: F6BAC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

880724:METIG RS07830
gene id: 880724:METIG_RS07830
uniprot id: F6BAZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

880724:METIG RS02045
gene id: 880724:METIG_RS02045
uniprot id: F6BB88
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

880724:METIG RS06160
gene id: 880724:METIG_RS06160
uniprot id: F6BE85
names: Similarity
messages: Belongs to the class-I fumarase family.

880724:METIG RS02660
gene id: 880724:METIG_RS02660
uniprot id: F6BC14
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

880724:METIG RS03605
gene id: 880724:METIG_RS03605
uniprot id: F6BCS1
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

880724:METIG RS03110
gene id: 880724:METIG_RS03110
uniprot id: F6BCH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

880724:METIG RS04530
gene id: 880724:METIG_RS04530
uniprot id: F6BD95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS04480
gene id: 880724:METIG_RS04480
uniprot id: F6BD85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS05580
gene id: 880724:METIG_RS05580
uniprot id: F6BDU0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS02895
gene id: 880724:METIG_RS02895
uniprot id: F6BCD1
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

880724:METIG RS06150
gene id: 880724:METIG_RS06150
uniprot id: F6BE83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

880724:METIG RS01665
gene id: 880724:METIG_RS01665
uniprot id: F6BAT1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

880724:METIG RS08235
gene id: 880724:METIG_RS08235
uniprot id: F6BBG0
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

880724:METIG RS01280
gene id: 880724:METIG_RS01280
uniprot id: F6BAC8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS02155
gene id: 880724:METIG_RS02155
uniprot id: F6BBI7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

880724:METIG RS02400
gene id: 880724:METIG_RS02400
uniprot id: F6BBN6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

880724:METIG RS03805
gene id: 880724:METIG_RS03805
uniprot id: F6BCV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

880724:METIG RS00200
gene id: 880724:METIG_RS00200
uniprot id: F6BEE0
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

880724:METIG RS01420
gene id: 880724:METIG_RS01420
uniprot id: F6BAN3
names: Similarity
messages: Belongs to the FUN14 family.

880724:METIG RS04310
gene id: 880724:METIG_RS04310
uniprot id: F6BD53
names: Similarity
messages: Belongs to the HupF/HypC family.

880724:METIG RS00305
gene id: 880724:METIG_RS00305
uniprot id: F6BEG1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

880724:METIG RS04175
gene id: 880724:METIG_RS04175
uniprot id: F6BD29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

880724:METIG RS01370
gene id: 880724:METIG_RS01370
uniprot id: F6BAM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

880724:METIG RS01940
gene id: 880724:METIG_RS01940
uniprot id: F6BB66
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

880724:METIG RS08360
gene id: 880724:METIG_RS08360
uniprot id: F6BBR3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

880724:METIG RS00845
gene id: 880724:METIG_RS00845
uniprot id: F6BEZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

880724:METIG RS00175
gene id: 880724:METIG_RS00175
uniprot id: F6BE60
names: Similarity
messages: Belongs to the GARS family.

880724:METIG RS07285
gene id: 880724:METIG_RS07285
uniprot id: F6BAG1
names: Similarity
messages: Belongs to the DEAD box helicase family.

880724:METIG RS04660
gene id: 880724:METIG_RS04660
uniprot id: F6BDB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

880724:METIG RS07350
gene id: 880724:METIG_RS07350
uniprot id: F6BAH5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

880724:METIG RS05165
gene id: 880724:METIG_RS05165
uniprot id: F6BDL4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS01595
gene id: 880724:METIG_RS01595
uniprot id: F6BAR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

880724:METIG RS06140
gene id: 880724:METIG_RS06140
uniprot id: F6BE81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

880724:METIG RS07940
gene id: 880724:METIG_RS07940
uniprot id: F6BB18
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

880724:METIG RS00630
gene id: 880724:METIG_RS00630
uniprot id: F6BEV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

880724:METIG RS08290
gene id: 880724:METIG_RS08290
uniprot id: F6BBH1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

880724:METIG RS02370
gene id: 880724:METIG_RS02370
uniprot id: F6BBN0
names: Similarity
messages: Belongs to the UPF0251 family.

880724:METIG RS08885
gene id: 880724:METIG_RS08885
uniprot id: F6BC92
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

880724:METIG RS03885
gene id: 880724:METIG_RS03885
uniprot id: F6BCX2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

880724:METIG RS08565
gene id: 880724:METIG_RS08565
uniprot id: F6BBV5
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS02715
gene id: 880724:METIG_RS02715
uniprot id: F6BC25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

880724:METIG RS05680
gene id: 880724:METIG_RS05680
uniprot id: F6BDW1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

880724:METIG RS06635
gene id: 880724:METIG_RS06635
uniprot id: F6BEQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

880724:METIG RS01680
gene id: 880724:METIG_RS01680
uniprot id: F6BAT4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

880724:METIG RS07775
gene id: 880724:METIG_RS07775
uniprot id: F6BAY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

880724:METIG RS03450
gene id: 880724:METIG_RS03450
uniprot id: F6BCP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

880724:METIG RS07745
gene id: 880724:METIG_RS07745
uniprot id: F6BAX9
names: Similarity
messages: Belongs to the UPF0210 family.

880724:METIG RS08265
gene id: 880724:METIG_RS08265
uniprot id: F6BBG6
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS06525
gene id: 880724:METIG_RS06525
uniprot id: F6BEN7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

880724:METIG RS01720
gene id: 880724:METIG_RS01720
uniprot id: F6BAU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

880724:METIG RS01545
gene id: 880724:METIG_RS01545
uniprot id: F6BAQ8
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

880724:METIG RS07685
gene id: 880724:METIG_RS07685
uniprot id: F6BAW7
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS02850
gene id: 880724:METIG_RS02850
uniprot id: F6BC52
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

880724:METIG RS08780
gene id: 880724:METIG_RS08780
uniprot id: F6BC71
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

880724:METIG RS02180
gene id: 880724:METIG_RS02180
uniprot id: F6BBJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

880724:METIG RS07875
gene id: 880724:METIG_RS07875
uniprot id: F6BB05
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS06510
gene id: 880724:METIG_RS06510
uniprot id: F6BEN4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

880724:METIG RS03695
gene id: 880724:METIG_RS03695
uniprot id: F6BCT8
names: Similarity
messages: Belongs to the HsdR family.

880724:METIG RS08250
gene id: 880724:METIG_RS08250
uniprot id: F6BBG4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

880724:METIG RS05105
gene id: 880724:METIG_RS05105
uniprot id: F6BDK2
names: Function
messages: Part of a potassium transport system.

880724:METIG RS04410
gene id: 880724:METIG_RS04410
uniprot id: F6BD71
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS05795
gene id: 880724:METIG_RS05795
uniprot id: F6BDY3
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

880724:METIG RS02205
gene id: 880724:METIG_RS02205
uniprot id: F6BBJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

880724:METIG RS03080
gene id: 880724:METIG_RS03080
uniprot id: F6BCG5
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

880724:METIG RS06480
gene id: 880724:METIG_RS06480
uniprot id: F6BEM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

880724:METIG RS03515
gene id: 880724:METIG_RS03515
uniprot id: F6BCQ3
names: Similarity
messages: Belongs to the P(II) protein family.

880724:METIG RS01350
gene id: 880724:METIG_RS01350
uniprot id: F6BAL9
names: Similarity
messages: Belongs to the UPF0292 family.

880724:METIG RS01295
gene id: 880724:METIG_RS01295
uniprot id: F6BAD1
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

880724:METIG RS08685
gene id: 880724:METIG_RS08685
uniprot id: F6BBX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

880724:METIG RS03240
gene id: 880724:METIG_RS03240
uniprot id: F6BCJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

880724:METIG RS04735
gene id: 880724:METIG_RS04735
uniprot id: F6BDD7
names: Similarity
messages: Belongs to the SDO1/SBDS family.

880724:METIG RS07520
gene id: 880724:METIG_RS07520
uniprot id: F6BAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

880724:METIG RS06015
gene id: 880724:METIG_RS06015
uniprot id: F6BE24
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

880724:METIG RS04185
gene id: 880724:METIG_RS04185
uniprot id: F6BD31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

880724:METIG RS04460
gene id: 880724:METIG_RS04460
uniprot id: F6BD81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

880724:METIG RS03150
gene id: 880724:METIG_RS03150
uniprot id: F6BCH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

880724:METIG RS01360
gene id: 880724:METIG_RS01360
uniprot id: F6BAM1
names: Similarity
messages: Belongs to the PstS family.

880724:METIG RS06560
gene id: 880724:METIG_RS06560
uniprot id: F6BEP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

880724:METIG RS00420
gene id: 880724:METIG_RS00420
uniprot id: F6BEI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS03760
gene id: 880724:METIG_RS03760
uniprot id: F6BCU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

880724:METIG RS01755
gene id: 880724:METIG_RS01755
uniprot id: F6BB28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

880724:METIG RS04575
gene id: 880724:METIG_RS04575
uniprot id: F6BDA4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

880724:METIG RS06220
gene id: 880724:METIG_RS06220
uniprot id: F6BE95
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

880724:METIG RS07185
gene id: 880724:METIG_RS07185
uniprot id: F6BF84
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-109 inactivates the nitrogenase reductase and regulates nitrogenase activity.

880724:METIG RS02710
gene id: 880724:METIG_RS02710
uniprot id: F6BC24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

880724:METIG RS03675
gene id: 880724:METIG_RS03675
uniprot id: F6BCT5
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

880724:METIG RS03460
gene id: 880724:METIG_RS03460
uniprot id: F6BCP2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS00370
gene id: 880724:METIG_RS00370
uniprot id: F6BEH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

880724:METIG RS02280
gene id: 880724:METIG_RS02280
uniprot id: F6BBL2
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

880724:METIG RS01635
gene id: 880724:METIG_RS01635
uniprot id: F6BAS5
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

880724:METIG RS03935
gene id: 880724:METIG_RS03935
uniprot id: F6BCY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

880724:METIG RS08345
gene id: 880724:METIG_RS08345
uniprot id: F6BBQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

880724:METIG RS06000
gene id: 880724:METIG_RS06000
uniprot id: F6BE21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

880724:METIG RS08750
gene id: 880724:METIG_RS08750
uniprot id: F6BC65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

880724:METIG RS00590
gene id: 880724:METIG_RS00590
uniprot id: F6BEU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

880724:METIG RS07455
gene id: 880724:METIG_RS07455
uniprot id: F6BAJ5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

880724:METIG RS00055
gene id: 880724:METIG_RS00055
uniprot id: F6BE38
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

880724:METIG RS02805
gene id: 880724:METIG_RS02805
uniprot id: F6BC43
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS06900
gene id: 880724:METIG_RS06900
uniprot id: F6BF35
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

880724:METIG RS00905
gene id: 880724:METIG_RS00905
uniprot id: F6BF04
names: Similarity
messages: Belongs to the UPF0173 family.

880724:METIG RS07985
gene id: 880724:METIG_RS07985
uniprot id: F6BBA7
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS07100
gene id: 880724:METIG_RS07100
uniprot id: F6BF67
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

880724:METIG RS01735
gene id: 880724:METIG_RS01735
uniprot id: F6BB24
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

880724:METIG RS00680
gene id: 880724:METIG_RS00680
uniprot id: F6BEW2
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

880724:METIG RS03480
gene id: 880724:METIG_RS03480
uniprot id: F6BCP6
names: Similarity
messages: Belongs to the NodU/CmcH family.

880724:METIG RS04255
gene id: 880724:METIG_RS04255
uniprot id: F6BD43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

880724:METIG RS05355
gene id: 880724:METIG_RS05355
uniprot id: F6BDP8
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS08875
gene id: 880724:METIG_RS08875
uniprot id: F6BC90
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS01660
gene id: 880724:METIG_RS01660
uniprot id: F6BAT0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

880724:METIG RS01490
gene id: 880724:METIG_RS01490
uniprot id: F6BAP7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

880724:METIG RS06985
gene id: 880724:METIG_RS06985
uniprot id: F6BF44
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

880724:METIG RS08730
gene id: 880724:METIG_RS08730
uniprot id: F6BC61
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

880724:METIG RS04540
gene id: 880724:METIG_RS04540
uniprot id: F6BD97
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

880724:METIG RS00345
gene id: 880724:METIG_RS00345
uniprot id: F6BEG9
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

880724:METIG RS06295
gene id: 880724:METIG_RS06295
uniprot id: F6BEB0
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

880724:METIG RS06815
gene id: 880724:METIG_RS06815
uniprot id: F6BF19
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

880724:METIG RS01000
gene id: 880724:METIG_RS01000
uniprot id: F6BA70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

880724:METIG RS01495
gene id: 880724:METIG_RS01495
uniprot id: F6BAP8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

880724:METIG RS06715
gene id: 880724:METIG_RS06715
uniprot id: F6BES5
names: Subunit
messages: Homotetramer.

880724:METIG RS03140
gene id: 880724:METIG_RS03140
uniprot id: F6BCH7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

880724:METIG RS00885
gene id: 880724:METIG_RS00885
uniprot id: F6BF00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

880724:METIG RS05765
gene id: 880724:METIG_RS05765
uniprot id: F6BDX7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

880724:METIG RS03510
gene id: 880724:METIG_RS03510
uniprot id: F6BCQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

880724:METIG RS00260
gene id: 880724:METIG_RS00260
uniprot id: F6BEF2
names: Similarity
messages: Belongs to the HerA family.

880724:METIG RS05135
gene id: 880724:METIG_RS05135
uniprot id: F6BDK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

880724:METIG RS06565
gene id: 880724:METIG_RS06565
uniprot id: F6BEP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

880724:METIG RS03980
gene id: 880724:METIG_RS03980
uniprot id: F6BCZ0
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

880724:METIG RS07845
gene id: 880724:METIG_RS07845
uniprot id: F6BAZ9
names: Similarity
messages: Belongs to the UPF0305 family.

880724:METIG RS01440
gene id: 880724:METIG_RS01440
uniprot id: F6BAN7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

880724:METIG RS00960
gene id: 880724:METIG_RS00960
uniprot id: F6BF16
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS08620
gene id: 880724:METIG_RS08620
uniprot id: F6BBW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

880724:METIG RS06155
gene id: 880724:METIG_RS06155
uniprot id: F6BE84
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

880724:METIG RS00830
gene id: 880724:METIG_RS00830
uniprot id: F6BEY9
names: Similarity
messages: Belongs to the MEMO1 family.

880724:METIG RS03095
gene id: 880724:METIG_RS03095
uniprot id: F6BCG8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

880724:METIG RS02800
gene id: 880724:METIG_RS02800
uniprot id: F6BC42
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

880724:METIG RS04515
gene id: 880724:METIG_RS04515
uniprot id: F6BD92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

880724:METIG RS02185
gene id: 880724:METIG_RS02185
uniprot id: F6BBJ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

880724:METIG RS05565
gene id: 880724:METIG_RS05565
uniprot id: F6BDT7
names: Similarity
messages: Belongs to the acylphosphatase family.

880724:METIG RS05180
gene id: 880724:METIG_RS05180
uniprot id: F6BDL7
names: Similarity
messages: Belongs to the glutamate synthase family.

880724:METIG RS05140
gene id: 880724:METIG_RS05140
uniprot id: F6BDK9
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

880724:METIG RS04490
gene id: 880724:METIG_RS04490
uniprot id: F6BD87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

880724:METIG RS08450
gene id: 880724:METIG_RS08450
uniprot id: F6BBT1
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS05805
gene id: 880724:METIG_RS05805
uniprot id: F6BDY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

880724:METIG RS08855
gene id: 880724:METIG_RS08855
uniprot id: F6BC86
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

880724:METIG RS01775
gene id: 880724:METIG_RS01775
uniprot id: F6BB32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

880724:METIG RS07130
gene id: 880724:METIG_RS07130
uniprot id: F6BF73
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

880724:METIG RS05455
gene id: 880724:METIG_RS05455
uniprot id: F6BDR7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

880724:METIG RS07760
gene id: 880724:METIG_RS07760
uniprot id: F6BAY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

880724:METIG RS07420
gene id: 880724:METIG_RS07420
uniprot id: F6BAI8
names: Similarity
messages: Belongs to the acylphosphatase family.

880724:METIG RS02810
gene id: 880724:METIG_RS02810
uniprot id: F6BC44
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS02720
gene id: 880724:METIG_RS02720
uniprot id: F6BC26
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

880724:METIG RS06265
gene id: 880724:METIG_RS06265
uniprot id: F6BEA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

880724:METIG RS07215
gene id: 880724:METIG_RS07215
uniprot id: F6BAE7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS04715
gene id: 880724:METIG_RS04715
uniprot id: F6BDD1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS08720
gene id: 880724:METIG_RS08720
uniprot id: F6BC59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

880724:METIG RS08300
gene id: 880724:METIG_RS08300
uniprot id: F6BBH3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS05120
gene id: 880724:METIG_RS05120
uniprot id: F6BDK5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

880724:METIG RS04745
gene id: 880724:METIG_RS04745
uniprot id: F6BDD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

880724:METIG RS01445
gene id: 880724:METIG_RS01445
uniprot id: F6BAN8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

880724:METIG RS04475
gene id: 880724:METIG_RS04475
uniprot id: F6BD84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

880724:METIG RS05040
gene id: 880724:METIG_RS05040
uniprot id: F6BDI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

880724:METIG RS01885
gene id: 880724:METIG_RS01885
uniprot id: F6BB55
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS00950
gene id: 880724:METIG_RS00950
uniprot id: F6BF14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

880724:METIG RS05525
gene id: 880724:METIG_RS05525
uniprot id: F6BDS9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

880724:METIG RS05945
gene id: 880724:METIG_RS05945
uniprot id: F6BE10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

880724:METIG RS02085
gene id: 880724:METIG_RS02085
uniprot id: F6BB97
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

880724:METIG RS02160
gene id: 880724:METIG_RS02160
uniprot id: F6BBI8
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

880724:METIG RS00555
gene id: 880724:METIG_RS00555
uniprot id: F6BEL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the hemerythrin family.
messages: Monomer.
messages: Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen-binding site contains two iron atoms.

880724:METIG RS04570
gene id: 880724:METIG_RS04570
uniprot id: F6BDA3
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS06665
gene id: 880724:METIG_RS06665
uniprot id: F6BER5
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

880724:METIG RS05220
gene id: 880724:METIG_RS05220
uniprot id: F6BDM4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

880724:METIG RS04295
gene id: 880724:METIG_RS04295
uniprot id: F6BD50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

880724:METIG RS04520
gene id: 880724:METIG_RS04520
uniprot id: F6BD93
names: Similarity
messages: Belongs to the SUI1 family.

880724:METIG RS07805
gene id: 880724:METIG_RS07805
uniprot id: F6BAZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

880724:METIG RS04655
gene id: 880724:METIG_RS04655
uniprot id: F6BDB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

880724:METIG RS06765
gene id: 880724:METIG_RS06765
uniprot id: F6BET2
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

880724:METIG RS06180
gene id: 880724:METIG_RS06180
uniprot id: F6BE89
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

880724:METIG RS01785
gene id: 880724:METIG_RS01785
uniprot id: F6BB34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

880724:METIG RS01135
gene id: 880724:METIG_RS01135
uniprot id: F6BA97
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS03160
gene id: 880724:METIG_RS03160
uniprot id: F6BE57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

880724:METIG RS06785
gene id: 880724:METIG_RS06785
uniprot id: F6BET6
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

880724:METIG RS07820
gene id: 880724:METIG_RS07820
uniprot id: F6BAZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS03420
gene id: 880724:METIG_RS03420
uniprot id: F6BCN4
names: Similarity
messages: Belongs to the UPF0288 family.

880724:METIG RS05435
gene id: 880724:METIG_RS05435
uniprot id: F6BDR4
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

880724:METIG RS01480
gene id: 880724:METIG_RS01480
uniprot id: F6BAP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

880724:METIG RS08925
gene id: 880724:METIG_RS08925
uniprot id: F6BCA1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

880724:METIG RS01845
gene id: 880724:METIG_RS01845
uniprot id: F6BB46
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

880724:METIG RS05290
gene id: 880724:METIG_RS05290
uniprot id: F6BDN5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

880724:METIG RS03415
gene id: 880724:METIG_RS03415
uniprot id: F6BCN3
names: Subunit
messages: Homotetramer.

880724:METIG RS05055
gene id: 880724:METIG_RS05055
uniprot id: F6BDJ2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

880724:METIG RS05415
gene id: 880724:METIG_RS05415
uniprot id: F6BDR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

880724:METIG RS03475
gene id: 880724:METIG_RS03475
uniprot id: F6BCP5
names: Similarity
messages: Belongs to the UPF0045 family.

880724:METIG RS07395
gene id: 880724:METIG_RS07395
uniprot id: F6BAI4
names: Similarity
messages: Belongs to the CutA family.

880724:METIG RS03010
gene id: 880724:METIG_RS03010
uniprot id: F6BCF2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

880724:METIG RS06230
gene id: 880724:METIG_RS06230
uniprot id: F6BE97
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

880724:METIG RS05145
gene id: 880724:METIG_RS05145
uniprot id: F6BDL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

880724:METIG RS03130
gene id: 880724:METIG_RS03130
uniprot id: F6BCH5
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS05960
gene id: 880724:METIG_RS05960
uniprot id: F6BE13
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

880724:METIG RS00390
gene id: 880724:METIG_RS00390
uniprot id: F6BEH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

880724:METIG RS04635
gene id: 880724:METIG_RS04635
uniprot id: F6BDB4
names: Similarity
messages: Belongs to the HisA/HisF family.

880724:METIG RS07210
gene id: 880724:METIG_RS07210
uniprot id: F6BAE6
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

880724:METIG RS06650
gene id: 880724:METIG_RS06650
uniprot id: F6BER2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

880724:METIG RS05430
gene id: 880724:METIG_RS05430
uniprot id: F6BDR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

880724:METIG RS06705
gene id: 880724:METIG_RS06705
uniprot id: F6BES3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

880724:METIG RS07195
gene id: 880724:METIG_RS07195
uniprot id: F6BAE3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

880724:METIG RS08005
gene id: 880724:METIG_RS08005
uniprot id: F6BBB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

880724:METIG RS02020
gene id: 880724:METIG_RS02020
uniprot id: F6BB83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS01765
gene id: 880724:METIG_RS01765
uniprot id: F6BB30
names: Similarity
messages: Belongs to the FrhG family.

880724:METIG RS05605
gene id: 880724:METIG_RS05605
uniprot id: F6BDU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

880724:METIG RS08160
gene id: 880724:METIG_RS08160
uniprot id: F6BBE5
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS07770
gene id: 880724:METIG_RS07770
uniprot id: F6BAY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

880724:METIG RS08365
gene id: 880724:METIG_RS08365
uniprot id: F6BBR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

880724:METIG RS03315
gene id: 880724:METIG_RS03315
uniprot id: F6BCL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

880724:METIG RS01240
gene id: 880724:METIG_RS01240
uniprot id: F6BAC0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

880724:METIG RS05275
gene id: 880724:METIG_RS05275
uniprot id: F6BDN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

880724:METIG RS08850
gene id: 880724:METIG_RS08850
uniprot id: F6BC85
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

880724:METIG RS01060
gene id: 880724:METIG_RS01060
uniprot id: F6BA82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

880724:METIG RS07595
gene id: 880724:METIG_RS07595
uniprot id: F6BAU9
names: Similarity
messages: Belongs to the UPF0107 family.

880724:METIG RS06910
gene id: 880724:METIG_RS06910
uniprot id: F6BF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

880724:METIG RS00970
gene id: 880724:METIG_RS00970
uniprot id: F6BA64
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

880724:METIG RS07780
gene id: 880724:METIG_RS07780
uniprot id: F6BAY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

880724:METIG RS06745
gene id: 880724:METIG_RS06745
uniprot id: F6BES8
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

880724:METIG RS05065
gene id: 880724:METIG_RS05065
uniprot id: F6BDJ4
names: Similarity
messages: Belongs to the MCM family.

880724:METIG RS06390
gene id: 880724:METIG_RS06390
uniprot id: F6BEC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BioW family.
messages: Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
messages: Homodimer.

880724:METIG RS02760
gene id: 880724:METIG_RS02760
uniprot id: F6BC34
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS04895
gene id: 880724:METIG_RS04895
uniprot id: F6BDG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

880724:METIG RS08595
gene id: 880724:METIG_RS08595
uniprot id: F6BBW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

880724:METIG RS03945
gene id: 880724:METIG_RS03945
uniprot id: F6BCY3
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

880724:METIG RS07580
gene id: 880724:METIG_RS07580
uniprot id: F6BAU6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

880724:METIG RS03170
gene id: 880724:METIG_RS03170
uniprot id: F6BCI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

880724:METIG RS07935
gene id: 880724:METIG_RS07935
uniprot id: F6BB17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

880724:METIG RS07365
gene id: 880724:METIG_RS07365
uniprot id: F6BAH8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

880724:METIG RS08975
gene id: 880724:METIG_RS08975
uniprot id: F6BCA9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

880724:METIG RS04740
gene id: 880724:METIG_RS04740
uniprot id: F6BDD8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

880724:METIG RS01925
gene id: 880724:METIG_RS01925
uniprot id: F6BB63
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS08035
gene id: 880724:METIG_RS08035
uniprot id: F6BBB9
names: Similarity
messages: Belongs to the MoaB/Mog family.

880724:METIG RS01730
gene id: 880724:METIG_RS01730
uniprot id: F6BAU4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

880724:METIG RS04770
gene id: 880724:METIG_RS04770
uniprot id: F6BDE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

880724:METIG RS03550
gene id: 880724:METIG_RS03550
uniprot id: F6BCR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

880724:METIG RS04205
gene id: 880724:METIG_RS04205
uniprot id: F6BD35
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

880724:METIG RS08900
gene id: 880724:METIG_RS08900
uniprot id: F6BC96
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

880724:METIG RS02095
gene id: 880724:METIG_RS02095
uniprot id: F6BB99
names: Similarity
messages: Belongs to the glutaredoxin family.

880724:METIG RS07165
gene id: 880724:METIG_RS07165
uniprot id: F6BF80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

880724:METIG RS08310
gene id: 880724:METIG_RS08310
uniprot id: F6BBH5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

880724:METIG RS03465
gene id: 880724:METIG_RS03465
uniprot id: F6BCP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

880724:METIG RS03120
gene id: 880724:METIG_RS03120
uniprot id: F6BCH3
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

880724:METIG RS08030
gene id: 880724:METIG_RS08030
uniprot id: F6BBB8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

880724:METIG RS00435
gene id: 880724:METIG_RS00435
uniprot id: F6BEI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

880724:METIG RS02920
gene id: 880724:METIG_RS02920
uniprot id: F6BCD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS08065
gene id: 880724:METIG_RS08065
uniprot id: F6BBC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

880724:METIG RS06285
gene id: 880724:METIG_RS06285
uniprot id: F6BEA8
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

880724:METIG RS06920
gene id: 880724:METIG_RS06920
uniprot id: F6BF39
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

880724:METIG RS04795
gene id: 880724:METIG_RS04795
uniprot id: F6BDF0
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS01365
gene id: 880724:METIG_RS01365
uniprot id: F6BAM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

880724:METIG RS08845
gene id: 880724:METIG_RS08845
uniprot id: F6BC84
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS08455
gene id: 880724:METIG_RS08455
uniprot id: F6BBT2
names: Similarity
messages: Belongs to the UPF0200 family.

880724:METIG RS08800
gene id: 880724:METIG_RS08800
uniprot id: F6BC75
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

880724:METIG RS03355
gene id: 880724:METIG_RS03355
uniprot id: F6BCM0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

880724:METIG RS04510
gene id: 880724:METIG_RS04510
uniprot id: F6BD91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS00355
gene id: 880724:METIG_RS00355
uniprot id: F6BEH1
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

880724:METIG RS04600
gene id: 880724:METIG_RS04600
uniprot id: F6BDA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

880724:METIG RS08355
gene id: 880724:METIG_RS08355
uniprot id: F6BBR2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

880724:METIG RS05405
gene id: 880724:METIG_RS05405
uniprot id: F6BDQ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

880724:METIG RS06585
gene id: 880724:METIG_RS06585
uniprot id: F6BEP9
names: Similarity
messages: Belongs to the UPF0273 family.

880724:METIG RS09060
gene id: 880724:METIG_RS09060
uniprot id: F6BCC6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

880724:METIG RS00780
gene id: 880724:METIG_RS00780
uniprot id: F6BEY0
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS06040
gene id: 880724:METIG_RS06040
uniprot id: F6BE63
names: Similarity
messages: Belongs to the FrhG family.

880724:METIG RS08630
gene id: 880724:METIG_RS08630
uniprot id: F6BBW7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

880724:METIG RS01535
gene id: 880724:METIG_RS01535
uniprot id: F6BAQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

880724:METIG RS08470
gene id: 880724:METIG_RS08470
uniprot id: F6BBT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

880724:METIG RS05905
gene id: 880724:METIG_RS05905
uniprot id: F6BE01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

880724:METIG RS00990
gene id: 880724:METIG_RS00990
uniprot id: F6BA68
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS01325
gene id: 880724:METIG_RS01325
uniprot id: F6BAD7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

880724:METIG RS02345
gene id: 880724:METIG_RS02345
uniprot id: F6BBM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

880724:METIG RS00980
gene id: 880724:METIG_RS00980
uniprot id: F6BA66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

880724:METIG RS06440
gene id: 880724:METIG_RS06440
uniprot id: F6BEM0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

880724:METIG RS06005
gene id: 880724:METIG_RS06005
uniprot id: F6BE22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

880724:METIG RS06790
gene id: 880724:METIG_RS06790
uniprot id: F6BET7
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS08415
gene id: 880724:METIG_RS08415
uniprot id: F6BBS4
names: Similarity
messages: Belongs to the AAA ATPase family.

880724:METIG RS08100
gene id: 880724:METIG_RS08100
uniprot id: F6BBD3
names: Similarity
messages: Belongs to the ZPR1 family.

880724:METIG RS04495
gene id: 880724:METIG_RS04495
uniprot id: F6BD88
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

880724:METIG RS08045
gene id: 880724:METIG_RS08045
uniprot id: F6BBC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

880724:METIG RS05315
gene id: 880724:METIG_RS05315
uniprot id: F6BDP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

880724:METIG RS00405
gene id: 880724:METIG_RS00405
uniprot id: F6BEI1
names: Similarity
messages: Belongs to the P(II) protein family.

880724:METIG RS07590
gene id: 880724:METIG_RS07590
uniprot id: F6BAU8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

880724:METIG RS00930
gene id: 880724:METIG_RS00930
uniprot id: F6BF09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

880724:METIG RS00820
gene id: 880724:METIG_RS00820
uniprot id: F6BEY8
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

880724:METIG RS03220
gene id: 880724:METIG_RS03220
uniprot id: F6BCJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

880724:METIG RS06720
gene id: 880724:METIG_RS06720
uniprot id: F6BES6
names: Similarity
messages: Belongs to the UPF0147 family.

880724:METIG RS05810
gene id: 880724:METIG_RS05810
uniprot id: F6BDY6
names: Similarity
messages: Belongs to the P(II) protein family.

880724:METIG RS03365
gene id: 880724:METIG_RS03365
uniprot id: F6BCM2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

880724:METIG RS08660
gene id: 880724:METIG_RS08660
uniprot id: F6BBX3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

880724:METIG RS08535
gene id: 880724:METIG_RS08535
uniprot id: F6BBU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

880724:METIG RS01320
gene id: 880724:METIG_RS01320
uniprot id: F6BAD6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

880724:METIG RS05130
gene id: 880724:METIG_RS05130
uniprot id: F6BDK7
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS01965
gene id: 880724:METIG_RS01965
uniprot id: F6BB71
names: Similarity
messages: Belongs to the UDPGP type 2 family.

880724:METIG RS04685
gene id: 880724:METIG_RS04685
uniprot id: G1UBJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

880724:METIG RS06250
gene id: 880724:METIG_RS06250
uniprot id: F6BEA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

880724:METIG RS07800
gene id: 880724:METIG_RS07800
uniprot id: F6BAZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

880724:METIG RS03770
gene id: 880724:METIG_RS03770
uniprot id: F6BCU9
names: Similarity
messages: Belongs to the UPF0047 family.

880724:METIG RS02065
gene id: 880724:METIG_RS02065
uniprot id: F6BB93
names: Similarity
messages: Belongs to the HdrC family.

880724:METIG RS03960
gene id: 880724:METIG_RS03960
uniprot id: F6BCY6
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

880724:METIG RS08495
gene id: 880724:METIG_RS08495
uniprot id: F6BBU0
names: Similarity
messages: Belongs to the TrpF family.

880724:METIG RS06780
gene id: 880724:METIG_RS06780
uniprot id: F6BET5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

880724:METIG RS01615
gene id: 880724:METIG_RS01615
uniprot id: F6BAS2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS07225
gene id: 880724:METIG_RS07225
uniprot id: F6BAE9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS00635
gene id: 880724:METIG_RS00635
uniprot id: F6BEV3
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

880724:METIG RS04910
gene id: 880724:METIG_RS04910
uniprot id: F6BDH0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

880724:METIG RS00310
gene id: 880724:METIG_RS00310
uniprot id: F6BEG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

880724:METIG RS07160
gene id: 880724:METIG_RS07160
uniprot id: F6BF79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

880724:METIG RS05235
gene id: 880724:METIG_RS05235
uniprot id: F6BDM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

880724:METIG RS09120
gene id: 880724:METIG_RS09120
uniprot id: F6BES9
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

880724:METIG RS03440
gene id: 880724:METIG_RS03440
uniprot id: F6BCN8
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS04980
gene id: 880724:METIG_RS04980
uniprot id: F6BDI3
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

880724:METIG RS01150
gene id: 880724:METIG_RS01150
uniprot id: F6BAA0
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS08740
gene id: 880724:METIG_RS08740
uniprot id: F6BC63
names: Similarity
messages: Belongs to the P(II) protein family.

880724:METIG RS00705
gene id: 880724:METIG_RS00705
uniprot id: F6BEW7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

880724:METIG RS00910
gene id: 880724:METIG_RS00910
uniprot id: F6BF05
names: Similarity
messages: Belongs to the peptidase U62 family.

880724:METIG RS00655
gene id: 880724:METIG_RS00655
uniprot id: F6BEV7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

880724:METIG RS01840
gene id: 880724:METIG_RS01840
uniprot id: F6BB45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

880724:METIG RS02320
gene id: 880724:METIG_RS02320
uniprot id: F6BBM0
names: Similarity
messages: Belongs to the FwdC/FmdC family.

880724:METIG RS04955
gene id: 880724:METIG_RS04955
uniprot id: F6BDH9
names: Similarity
messages: Belongs to the HMD family.

880724:METIG RS02835
gene id: 880724:METIG_RS02835
uniprot id: F6BC49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

880724:METIG RS00855
gene id: 880724:METIG_RS00855
uniprot id: F6BEZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

880724:METIG RS02600
gene id: 880724:METIG_RS02600
uniprot id: F6BC03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

880724:METIG RS04105
gene id: 880724:METIG_RS04105
uniprot id: F6BD16
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

880724:METIG RS06925
gene id: 880724:METIG_RS06925
uniprot id: F6BF40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

880724:METIG RS00105
gene id: 880724:METIG_RS00105
uniprot id: F6BE47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

880724:METIG RS06345
gene id: 880724:METIG_RS06345
uniprot id: F6BEC0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

880724:METIG RS06625
gene id: 880724:METIG_RS06625
uniprot id: F6BEQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

880724:METIG RS03650
gene id: 880724:METIG_RS03650
uniprot id: F6BCS9
names: Similarity
messages: Belongs to the UPF0216 family.

880724:METIG RS05890
gene id: 880724:METIG_RS05890
uniprot id: F6BDZ8
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS08880
gene id: 880724:METIG_RS08880
uniprot id: F6BC91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

880724:METIG RS07140
gene id: 880724:METIG_RS07140
uniprot id: F6BF75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

880724:METIG RS01800
gene id: 880724:METIG_RS01800
uniprot id: F6BB37
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

880724:METIG RS08735
gene id: 880724:METIG_RS08735
uniprot id: F6BC62
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-108 inactivates the nitrogenase reductase and regulates nitrogenase activity.

880724:METIG RS06980
gene id: 880724:METIG_RS06980
uniprot id: F6BF43
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

880724:METIG RS00995
gene id: 880724:METIG_RS00995
uniprot id: F6BA69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

880724:METIG RS05585
gene id: 880724:METIG_RS05585
uniprot id: F6BDU1
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

880724:METIG RS04730
gene id: 880724:METIG_RS04730
uniprot id: F6BDD6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

880724:METIG RS05570
gene id: 880724:METIG_RS05570
uniprot id: F6BDT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

880724:METIG RS04470
gene id: 880724:METIG_RS04470
uniprot id: F6BD83
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

880724:METIG RS03950
gene id: 880724:METIG_RS03950
uniprot id: F6BCY4
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS01935
gene id: 880724:METIG_RS01935
uniprot id: F6BB65
names: Similarity
messages: Belongs to the TrpC family.

880724:METIG RS07555
gene id: 880724:METIG_RS07555
uniprot id: F6BAL5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS08395
gene id: 880724:METIG_RS08395
uniprot id: F6BBS0
names: Similarity
messages: Belongs to the UPF0237 family.

880724:METIG RS05555
gene id: 880724:METIG_RS05555
uniprot id: F6BDT5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

880724:METIG RS00575
gene id: 880724:METIG_RS00575
uniprot id: F6BEU2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

880724:METIG RS04270
gene id: 880724:METIG_RS04270
uniprot id: F6BD46
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

880724:METIG RS01820
gene id: 880724:METIG_RS01820
uniprot id: F6BB41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

880724:METIG RS07810
gene id: 880724:METIG_RS07810
uniprot id: F6BAZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

880724:METIG RS00005
gene id: 880724:METIG_RS00005
uniprot id: F6BE28
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

880724:METIG RS02980
gene id: 880724:METIG_RS02980
uniprot id: F6BCE9
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

880724:METIG RS09055
gene id: 880724:METIG_RS09055
uniprot id: F6BCC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

880724:METIG RS03570
gene id: 880724:METIG_RS03570
uniprot id: F6BCR4
names: Similarity
messages: Belongs to the UPF0235 family.

880724:METIG RS02350
gene id: 880724:METIG_RS02350
uniprot id: F6BBM6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

880724:METIG RS03230
gene id: 880724:METIG_RS03230
uniprot id: F6BCJ4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

880724:METIG RS08185
gene id: 880724:METIG_RS08185
uniprot id: F6BBF0
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

880724:METIG RS06030
gene id: 880724:METIG_RS06030
uniprot id: F6BE61
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

880724:METIG RS07135
gene id: 880724:METIG_RS07135
uniprot id: F6BF74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

880724:METIG RS01015
gene id: 880724:METIG_RS01015
uniprot id: F6BA73
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

880724:METIG RS01875
gene id: 880724:METIG_RS01875
uniprot id: F6BB53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

880724:METIG RS08690
gene id: 880724:METIG_RS08690
uniprot id: F6BBX9
names: Similarity
messages: Belongs to the AOR/FOR family.

880724:METIG RS08020
gene id: 880724:METIG_RS08020
uniprot id: F6BBB5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

880724:METIG RS00720
gene id: 880724:METIG_RS00720
uniprot id: F6BEX0
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS07825
gene id: 880724:METIG_RS07825
uniprot id: F6BAZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

880724:METIG RS08970
gene id: 880724:METIG_RS08970
uniprot id: F6BCA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

880724:METIG RS00600
gene id: 880724:METIG_RS00600
uniprot id: F6BEU7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS08895
gene id: 880724:METIG_RS08895
uniprot id: F6BC95
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

880724:METIG RS03835
gene id: 880724:METIG_RS03835
uniprot id: F6BCW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

880724:METIG RS04060
gene id: 880724:METIG_RS04060
uniprot id: F6BD07
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

880724:METIG RS04260
gene id: 880724:METIG_RS04260
uniprot id: F6BD44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS04350
gene id: 880724:METIG_RS04350
uniprot id: F6BD60
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS06425
gene id: 880724:METIG_RS06425
uniprot id: F6BEL7
names: Function
names: Similarity
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

880724:METIG RS03815
gene id: 880724:METIG_RS03815
uniprot id: F6BCV8
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

880724:METIG RS08510
gene id: 880724:METIG_RS08510
uniprot id: F6BBU3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

880724:METIG RS01600
gene id: 880724:METIG_RS01600
uniprot id: F6BAR9
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS02290
gene id: 880724:METIG_RS02290
uniprot id: F6BBL4
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

880724:METIG RS03500
gene id: 880724:METIG_RS03500
uniprot id: F6BCQ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

880724:METIG RS02080
gene id: 880724:METIG_RS02080
uniprot id: F6BB96
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

880724:METIG RS07905
gene id: 880724:METIG_RS07905
uniprot id: F6BB11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

880724:METIG RS05695
gene id: 880724:METIG_RS05695
uniprot id: F6BDW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

880724:METIG RS01675
gene id: 880724:METIG_RS01675
uniprot id: F6BAT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

880724:METIG RS01405
gene id: 880724:METIG_RS01405
uniprot id: F6BAN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

880724:METIG RS06470
gene id: 880724:METIG_RS06470
uniprot id: F6BEM6
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

880724:METIG RS07815
gene id: 880724:METIG_RS07815
uniprot id: F6BAZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

880724:METIG RS07835
gene id: 880724:METIG_RS07835
uniprot id: F6BAZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

880724:METIG RS08240
gene id: 880724:METIG_RS08240
uniprot id: F6BBG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

880724:METIG RS06375
gene id: 880724:METIG_RS06375
uniprot id: F6BEC6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS03920
gene id: 880724:METIG_RS03920
uniprot id: F6BCX9
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

880724:METIG RS08585
gene id: 880724:METIG_RS08585
uniprot id: F6BBV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

880724:METIG RS06845
gene id: 880724:METIG_RS06845
uniprot id: F6BF25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

880724:METIG RS08465
gene id: 880724:METIG_RS08465
uniprot id: F6BBT4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

880724:METIG RS05150
gene id: 880724:METIG_RS05150
uniprot id: F6BDL1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

880724:METIG RS04225
gene id: 880724:METIG_RS04225
uniprot id: F6BD39
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

880724:METIG RS01790
gene id: 880724:METIG_RS01790
uniprot id: F6BB35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

880724:METIG RS08490
gene id: 880724:METIG_RS08490
uniprot id: F6BBT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

880724:METIG RS06255
gene id: 880724:METIG_RS06255
uniprot id: F6BEA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

880724:METIG RS01065
gene id: 880724:METIG_RS01065
uniprot id: F6BA83
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS04045
gene id: 880724:METIG_RS04045
uniprot id: F6BD04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

880724:METIG RS04990
gene id: 880724:METIG_RS04990
uniprot id: F6BDI5
names: Similarity
messages: Belongs to the UPF0146 family.

880724:METIG RS04810
gene id: 880724:METIG_RS04810
uniprot id: F6BDF3
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS08675
gene id: 880724:METIG_RS08675
uniprot id: F6BBX6
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

880724:METIG RS03775
gene id: 880724:METIG_RS03775
uniprot id: F6BCV0
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

880724:METIG RS02190
gene id: 880724:METIG_RS02190
uniprot id: F6BBJ3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

880724:METIG RS05835
gene id: 880724:METIG_RS05835
uniprot id: F6BDY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

880724:METIG RS00700
gene id: 880724:METIG_RS00700
uniprot id: F6BEW6
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

880724:METIG RS08505
gene id: 880724:METIG_RS08505
uniprot id: F6BBU2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

880724:METIG RS01340
gene id: 880724:METIG_RS01340
uniprot id: F6BAE1
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS03525
gene id: 880724:METIG_RS03525
uniprot id: F6BCQ5
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

880724:METIG RS06245
gene id: 880724:METIG_RS06245
uniprot id: F6BEA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

880724:METIG RS06755
gene id: 880724:METIG_RS06755
uniprot id: F6BET0
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

880724:METIG RS08305
gene id: 880724:METIG_RS08305
uniprot id: F6BBH4
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS04150
gene id: 880724:METIG_RS04150
uniprot id: F6BD25
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

880724:METIG RS00740
gene id: 880724:METIG_RS00740
uniprot id: F6BEX4
names: Similarity
messages: Belongs to the UPF0310 family.

880724:METIG RS01880
gene id: 880724:METIG_RS01880
uniprot id: F6BB54
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS08995
gene id: 880724:METIG_RS08995
uniprot id: F6BCB3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

880724:METIG RS03075
gene id: 880724:METIG_RS03075
uniprot id: F6BCG4
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

880724:METIG RS07550
gene id: 880724:METIG_RS07550
uniprot id: F6BAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

880724:METIG RS03620
gene id: 880724:METIG_RS03620
uniprot id: F6BCS4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

880724:METIG RS05930
gene id: 880724:METIG_RS05930
uniprot id: F6BE07
names: Similarity
messages: Belongs to the UPF0111 family.

880724:METIG RS07500
gene id: 880724:METIG_RS07500
uniprot id: F6BAK4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

880724:METIG RS00495
gene id: 880724:METIG_RS00495
uniprot id: F6BEJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

880724:METIG RS00060
gene id: 880724:METIG_RS00060
uniprot id: F6BE39
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

880724:METIG RS04850
gene id: 880724:METIG_RS04850
uniprot id: F6BDG1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

880724:METIG RS06455
gene id: 880724:METIG_RS06455
uniprot id: F6BEM3
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS04465
gene id: 880724:METIG_RS04465
uniprot id: F6BD82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

880724:METIG RS02770
gene id: 880724:METIG_RS02770
uniprot id: F6BC36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

880724:METIG RS05265
gene id: 880724:METIG_RS05265
uniprot id: F6BDN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

880724:METIG RS05440
gene id: 880724:METIG_RS05440
uniprot id: F6BDR5
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

880724:METIG RS06270
gene id: 880724:METIG_RS06270
uniprot id: F6BEA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

880724:METIG RS06185
gene id: 880724:METIG_RS06185
uniprot id: F6BE90
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS04830
gene id: 880724:METIG_RS04830
uniprot id: F6BDF7
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS06385
gene id: 880724:METIG_RS06385
uniprot id: F6BEC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

880724:METIG RS00120
gene id: 880724:METIG_RS00120
uniprot id: F6BE50
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS08560
gene id: 880724:METIG_RS08560
uniprot id: F6BBV4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS00230
gene id: 880724:METIG_RS00230
uniprot id: F6BEE6
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

880724:METIG RS08110
gene id: 880724:METIG_RS08110
uniprot id: F6BBD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EhaA family.
messages: Cell membrane
messages: Membrane
messages: One of the integral membrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase eha. Eha is predicted to form large electron transfer complex and might catalyze energy-driven reduction of low-potential redox carriers.
messages: Putative multisubunit membrane-bound [NiFe]-hydrogenase eha is composed of at least 20 subunits.

880724:METIG RS06725
gene id: 880724:METIG_RS06725
uniprot id: F6BES7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

880724:METIG RS09010
gene id: 880724:METIG_RS09010
uniprot id: F6BCB6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

880724:METIG RS00250
gene id: 880724:METIG_RS00250
uniprot id: F6BEF0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS03125
gene id: 880724:METIG_RS03125
uniprot id: F6BCH4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

880724:METIG RS03790
gene id: 880724:METIG_RS03790
uniprot id: F6BCV3
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

880724:METIG RS03375
gene id: 880724:METIG_RS03375
uniprot id: F6BCM5
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

880724:METIG RS04330
gene id: 880724:METIG_RS04330
uniprot id: F6BD56
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

880724:METIG RS03210
gene id: 880724:METIG_RS03210
uniprot id: F6BCJ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS06475
gene id: 880724:METIG_RS06475
uniprot id: F6BEM7
names: Similarity
messages: Belongs to the Nth/MutY family.

880724:METIG RS00090
gene id: 880724:METIG_RS00090
uniprot id: F6BE44
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

880724:METIG RS04680
gene id: 880724:METIG_RS04680
uniprot id: G1UBJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

880724:METIG RS04275
gene id: 880724:METIG_RS04275
uniprot id: F6BD47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

880724:METIG RS08295
gene id: 880724:METIG_RS08295
uniprot id: F6BBH2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

880724:METIG RS04170
gene id: 880724:METIG_RS04170
uniprot id: F6BD28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

880724:METIG RS05085
gene id: 880724:METIG_RS05085
uniprot id: F6BDJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

880724:METIG RS05940
gene id: 880724:METIG_RS05940
uniprot id: F6BE09
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

880724:METIG RS04525
gene id: 880724:METIG_RS04525
uniprot id: F6BD94
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

880724:METIG RS02005
gene id: 880724:METIG_RS02005
uniprot id: F6BB79
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS07465
gene id: 880724:METIG_RS07465
uniprot id: F6BAJ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

880724:METIG RS05505
gene id: 880724:METIG_RS05505
uniprot id: F6BDS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

880724:METIG RS03425
gene id: 880724:METIG_RS03425
uniprot id: F6BCN5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

880724:METIG RS05665
gene id: 880724:METIG_RS05665
uniprot id: F6BDV8
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

880724:METIG RS04035
gene id: 880724:METIG_RS04035
uniprot id: F6BD02
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS07280
gene id: 880724:METIG_RS07280
uniprot id: F6BAG0
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

880724:METIG RS04230
gene id: 880724:METIG_RS04230
uniprot id: F6BD40
names: Similarity
messages: Belongs to the HypE family.

880724:METIG RS01210
gene id: 880724:METIG_RS01210
uniprot id: F6BAB4
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS06460
gene id: 880724:METIG_RS06460
uniprot id: F6BEM4
names: Similarity
messages: Belongs to the class-I fumarase family.

880724:METIG RS06135
gene id: 880724:METIG_RS06135
uniprot id: F6BE80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

880724:METIG RS03940
gene id: 880724:METIG_RS03940
uniprot id: F6BCY2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

880724:METIG RS06365
gene id: 880724:METIG_RS06365
uniprot id: F6BEC4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

880724:METIG RS03430
gene id: 880724:METIG_RS03430
uniprot id: F6BCN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

880724:METIG RS00220
gene id: 880724:METIG_RS00220
uniprot id: F6BEE4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

880724:METIG RS05410
gene id: 880724:METIG_RS05410
uniprot id: F6BDQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

880724:METIG RS04450
gene id: 880724:METIG_RS04450
uniprot id: F6BD79
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

880724:METIG RS04165
gene id: 880724:METIG_RS04165
uniprot id: F6BD27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

880724:METIG RS06300
gene id: 880724:METIG_RS06300
uniprot id: F6BEB1
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

880724:METIG RS03830
gene id: 880724:METIG_RS03830
uniprot id: F6BCW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

880724:METIG RS02935
gene id: 880724:METIG_RS02935
uniprot id: F6BCD9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

880724:METIG RS02665
gene id: 880724:METIG_RS02665
uniprot id: F6BC15
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

880724:METIG RS04690
gene id: 880724:METIG_RS04690
uniprot id: G1UBJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

880724:METIG RS06430
gene id: 880724:METIG_RS06430
uniprot id: F6BEL8
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS03275
gene id: 880724:METIG_RS03275
uniprot id: F6BCK3
names: Caution
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS02340
gene id: 880724:METIG_RS02340
uniprot id: F6BBM4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

880724:METIG RS01920
gene id: 880724:METIG_RS01920
uniprot id: F6BB62
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

880724:METIG RS07540
gene id: 880724:METIG_RS07540
uniprot id: F6BAL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

880724:METIG RS01020
gene id: 880724:METIG_RS01020
uniprot id: F6BA74
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

880724:METIG RS06145
gene id: 880724:METIG_RS06145
uniprot id: F6BE82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

880724:METIG RS05095
gene id: 880724:METIG_RS05095
uniprot id: F6BDK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

880724:METIG RS02010
gene id: 880724:METIG_RS02010
uniprot id: F6BB81
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

880724:METIG RS02880
gene id: 880724:METIG_RS02880
uniprot id: F6BC58
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

880724:METIG RS06235
gene id: 880724:METIG_RS06235
uniprot id: F6BE98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

880724:METIG RS06225
gene id: 880724:METIG_RS06225
uniprot id: F6BE96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

880724:METIG RS05785
gene id: 880724:METIG_RS05785
uniprot id: F6BDY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS00300
gene id: 880724:METIG_RS00300
uniprot id: F6BEG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

880724:METIG RS02595
gene id: 880724:METIG_RS02595
uniprot id: F6BC02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

880724:METIG RS02565
gene id: 880724:METIG_RS02565
uniprot id: F6BBZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

880724:METIG RS05690
gene id: 880724:METIG_RS05690
uniprot id: F6BDW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

880724:METIG RS07615
gene id: 880724:METIG_RS07615
uniprot id: F6BAV3
names: Similarity
messages: Belongs to the peptidase S49 family.

880724:METIG RS00155
gene id: 880724:METIG_RS00155
uniprot id: F6BE56
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

880724:METIG RS06420
gene id: 880724:METIG_RS06420
uniprot id: F6BEL6
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

880724:METIG RS05385
gene id: 880724:METIG_RS05385
uniprot id: F6BDQ4
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS03635
gene id: 880724:METIG_RS03635
uniprot id: F6BCS6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

880724:METIG RS04125
gene id: 880724:METIG_RS04125
uniprot id: F6BD20
names: Similarity
messages: Belongs to the UPF0248 family.

880724:METIG RS01380
gene id: 880724:METIG_RS01380
uniprot id: F6BAM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

880724:METIG RS07360
gene id: 880724:METIG_RS07360
uniprot id: F6BAH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

880724:METIG RS03595
gene id: 880724:METIG_RS03595
uniprot id: F6BCR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

880724:METIG RS04095
gene id: 880724:METIG_RS04095
uniprot id: F6BD14
names: Similarity
messages: Belongs to the DMRL synthase family.

880724:METIG RS07510
gene id: 880724:METIG_RS07510
uniprot id: F6BAK6
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

880724:METIG RS00195
gene id: 880724:METIG_RS00195
uniprot id: F6BED9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS02925
gene id: 880724:METIG_RS02925
uniprot id: F6BCD7
names: Similarity
messages: Belongs to the PDCD5 family.

880724:METIG RS07735
gene id: 880724:METIG_RS07735
uniprot id: F6BAX7
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS05530
gene id: 880724:METIG_RS05530
uniprot id: F6BDT0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

880724:METIG RS01315
gene id: 880724:METIG_RS01315
uniprot id: F6BAD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

880724:METIG RS07340
gene id: 880724:METIG_RS07340
uniprot id: F6BAH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

880724:METIG RS08680
gene id: 880724:METIG_RS08680
uniprot id: F6BBX7
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS00640
gene id: 880724:METIG_RS00640
uniprot id: F6BEV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

880724:METIG RS01995
gene id: 880724:METIG_RS01995
uniprot id: F6BB77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

880724:METIG RS08940
gene id: 880724:METIG_RS08940
uniprot id: F6BCA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

880724:METIG RS04760
gene id: 880724:METIG_RS04760
uniprot id: F6BDE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

880724:METIG RS08910
gene id: 880724:METIG_RS08910
uniprot id: F6BC98
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS04030
gene id: 880724:METIG_RS04030
uniprot id: F6BD01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

880724:METIG RS03270
gene id: 880724:METIG_RS03270
uniprot id: F6BCK2
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS01140
gene id: 880724:METIG_RS01140
uniprot id: F6BA98
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS08745
gene id: 880724:METIG_RS08745
uniprot id: F6BC64
names: Similarity
messages: Belongs to the P(II) protein family.

880724:METIG RS02635
gene id: 880724:METIG_RS02635
uniprot id: F6BC10
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS08485
gene id: 880724:METIG_RS08485
uniprot id: F6BBT8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

880724:METIG RS06490
gene id: 880724:METIG_RS06490
uniprot id: F6BEN0
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

880724:METIG RS03165
gene id: 880724:METIG_RS03165
uniprot id: F6BCI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

880724:METIG RS07045
gene id: 880724:METIG_RS07045
uniprot id: F6BF56
names: Similarity
messages: Belongs to the UPF0282 family.

880724:METIG RS04250
gene id: 880724:METIG_RS04250
uniprot id: F6BD42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

880724:METIG RS06060
gene id: 880724:METIG_RS06060
uniprot id: F6BE67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

880724:METIG RS03780
gene id: 880724:METIG_RS03780
uniprot id: F6BCV1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

880724:METIG RS08425
gene id: 880724:METIG_RS08425
uniprot id: F6BBS6
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS07335
gene id: 880724:METIG_RS07335
uniprot id: F6BAH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

880724:METIG RS01870
gene id: 880724:METIG_RS01870
uniprot id: F6BB52
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS04425
gene id: 880724:METIG_RS04425
uniprot id: F6BD74
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS04180
gene id: 880724:METIG_RS04180
uniprot id: F6BD30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

880724:METIG RS04265
gene id: 880724:METIG_RS04265
uniprot id: F6BD45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

880724:METIG RS01470
gene id: 880724:METIG_RS01470
uniprot id: F6BAP3
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

880724:METIG RS04430
gene id: 880724:METIG_RS04430
uniprot id: F6BD75
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

880724:METIG RS03730
gene id: 880724:METIG_RS03730
uniprot id: F6BCU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

880724:METIG RS07925
gene id: 880724:METIG_RS07925
uniprot id: F6BB15
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

880724:METIG RS03260
gene id: 880724:METIG_RS03260
uniprot id: F6BCK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

880724:METIG RS01145
gene id: 880724:METIG_RS01145
uniprot id: F6BA99
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS00865
gene id: 880724:METIG_RS00865
uniprot id: F6BEZ6
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

880724:METIG RS04970
gene id: 880724:METIG_RS04970
uniprot id: F6BDI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

880724:METIG RS07260
gene id: 880724:METIG_RS07260
uniprot id: F6BAF6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

880724:METIG RS03225
gene id: 880724:METIG_RS03225
uniprot id: F6BCJ3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

880724:METIG RS02875
gene id: 880724:METIG_RS02875
uniprot id: F6BC57
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

880724:METIG RS05035
gene id: 880724:METIG_RS05035
uniprot id: F6BDI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

880724:METIG RS06495
gene id: 880724:METIG_RS06495
uniprot id: F6BEN1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

880724:METIG RS08590
gene id: 880724:METIG_RS08590
uniprot id: F6BBW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

880724:METIG RS03305
gene id: 880724:METIG_RS03305
uniprot id: F6BCL0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

880724:METIG RS00280
gene id: 880724:METIG_RS00280
uniprot id: F6BEF6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

880724:METIG RS02170
gene id: 880724:METIG_RS02170
uniprot id: F6BBI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

880724:METIG RS02415
gene id: 880724:METIG_RS02415
uniprot id: F6BBN9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

880724:METIG RS03300
gene id: 880724:METIG_RS03300
uniprot id: F6BCK9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

880724:METIG RS06090
gene id: 880724:METIG_RS06090
uniprot id: F6BE73
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS02830
gene id: 880724:METIG_RS02830
uniprot id: F6BC48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

880724:METIG RS08575
gene id: 880724:METIG_RS08575
uniprot id: F6BBV7
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS05080
gene id: 880724:METIG_RS05080
uniprot id: F6BDJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

880724:METIG RS08725
gene id: 880724:METIG_RS08725
uniprot id: F6BC60
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

880724:METIG RS04405
gene id: 880724:METIG_RS04405
uniprot id: F6BD70
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

880724:METIG RS04930
gene id: 880724:METIG_RS04930
uniprot id: F6BDH4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

880724:METIG RS05155
gene id: 880724:METIG_RS05155
uniprot id: F6BDL2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS04190
gene id: 880724:METIG_RS04190
uniprot id: F6BD32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

880724:METIG RS01130
gene id: 880724:METIG_RS01130
uniprot id: F6BA96
names: Similarity
messages: Belongs to the archaeal ATPase family.

880724:METIG RS08260
gene id: 880724:METIG_RS08260
uniprot id: F6BBG5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

880724:METIG RS05070
gene id: 880724:METIG_RS05070
uniprot id: F6BDJ5
names: Similarity
messages: Belongs to the UPF0179 family.

880724:METIG RS06840
gene id: 880724:METIG_RS06840
uniprot id: F6BF24
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

880724:METIG RS07380
gene id: 880724:METIG_RS07380
uniprot id: F6BAI1
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS01055
gene id: 880724:METIG_RS01055
uniprot id: F6BA81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

880724:METIG RS03435
gene id: 880724:METIG_RS03435
uniprot id: F6BCN7
names: Similarity
messages: Belongs to the UPF0215 family.

880724:METIG RS02405
gene id: 880724:METIG_RS02405
uniprot id: F6BBN7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

880724:METIG RS01865
gene id: 880724:METIG_RS01865
uniprot id: F6BB51
names: Similarity
messages: Belongs to the UPF0252 family.

880724:METIG RS09040
gene id: 880724:METIG_RS09040
uniprot id: F6BCC2
names: Subcellular Location Annotation
messages: Membrane

880724:METIG RS03135
gene id: 880724:METIG_RS03135
uniprot id: F6BCH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

880724:METIG RS04455
gene id: 880724:METIG_RS04455
uniprot id: F6BD80
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

880724:METIG RS00185
gene id: 880724:METIG_RS00185
uniprot id: F6BED7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

880724:METIG RS06355
gene id: 880724:METIG_RS06355
uniprot id: F6BEC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

880724:METIG RS09015
gene id: 880724:METIG_RS09015
uniprot id: F6BCB7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

880724:METIG RS00595
gene id: 880724:METIG_RS00595
uniprot id: F6BEU6
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

880724:METIG RS00675
gene id: 880724:METIG_RS00675
uniprot id: F6BEW1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

880724:METIG RS06775
gene id: 880724:METIG_RS06775
uniprot id: F6BET4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

880724:METIG RS03530
gene id: 880724:METIG_RS03530
uniprot id: F6BCQ6
names: Similarity
messages: Belongs to the UPF0254 family.

880724:METIG RS04505
gene id: 880724:METIG_RS04505
uniprot id: F6BD90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

880724:METIG RS03090
gene id: 880724:METIG_RS03090
uniprot id: F6BCG7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

880724:METIG RS08830
gene id: 880724:METIG_RS08830
uniprot id: F6BC81
names: Similarity
messages: Belongs to the acylphosphatase family.