867904:METHO RS05120
gene id: 867904:METHO_RS05120
uniprot id: L0KXA9
names: Similarity
messages: Belongs to the P(II) protein family.

867904:METHO RS11785
gene id: 867904:METHO_RS11785
uniprot id: L0L2E9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

867904:METHO RS03800
gene id: 867904:METHO_RS03800
uniprot id: L0KV65
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

867904:METHO RS10950
gene id: 867904:METHO_RS10950
uniprot id: L0L201
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

867904:METHO RS00570
gene id: 867904:METHO_RS00570
uniprot id: L0KSL2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

867904:METHO RS09040
gene id: 867904:METHO_RS09040
uniprot id: L0L1B3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

867904:METHO RS01950
gene id: 867904:METHO_RS01950
uniprot id: L0KX67
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

867904:METHO RS00975
gene id: 867904:METHO_RS00975
uniprot id: L0KSS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

867904:METHO RS08790
gene id: 867904:METHO_RS08790
uniprot id: L0L169
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS00340
gene id: 867904:METHO_RS00340
uniprot id: L0KWD2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

867904:METHO RS09155
gene id: 867904:METHO_RS09155
uniprot id: L0L111
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

867904:METHO RS03265
gene id: 867904:METHO_RS03265
uniprot id: L0KUX6
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS02705
gene id: 867904:METHO_RS02705
uniprot id: L0KVX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

867904:METHO RS08600
gene id: 867904:METHO_RS08600
uniprot id: L0KX11
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

867904:METHO RS02755
gene id: 867904:METHO_RS02755
uniprot id: L0KVY2
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

867904:METHO RS01365
gene id: 867904:METHO_RS01365
uniprot id: L0KSZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

867904:METHO RS08555
gene id: 867904:METHO_RS08555
uniprot id: L0L0Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

867904:METHO RS03995
gene id: 867904:METHO_RS03995
uniprot id: L0KYK6
names: Similarity
messages: Belongs to the Ahb/Nir family.

867904:METHO RS04300
gene id: 867904:METHO_RS04300
uniprot id: L0KWQ9
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09185
gene id: 867904:METHO_RS09185
uniprot id: L0L115
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

867904:METHO RS02205
gene id: 867904:METHO_RS02205
uniprot id: L0KXB6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

867904:METHO RS10910
gene id: 867904:METHO_RS10910
uniprot id: L0L0G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.
messages: Homodimer.

867904:METHO RS11360
gene id: 867904:METHO_RS11360
uniprot id: L0L276
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS00875
gene id: 867904:METHO_RS00875
uniprot id: L0KSR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

867904:METHO RS09020
gene id: 867904:METHO_RS09020
uniprot id: L0KZD3
names: Similarity
messages: Belongs to the SDO1/SBDS family.

867904:METHO RS09900
gene id: 867904:METHO_RS09900
uniprot id: L0KXP3
names: Similarity
messages: Belongs to the archaeal-type GPI family.

867904:METHO RS03890
gene id: 867904:METHO_RS03890
uniprot id: L0KYI7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

867904:METHO RS04175
gene id: 867904:METHO_RS04175
uniprot id: L0KUI9
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09330
gene id: 867904:METHO_RS09330
uniprot id: L0KYD2
names: Similarity
messages: Belongs to the pyruvate kinase family.

867904:METHO RS10600
gene id: 867904:METHO_RS10600
uniprot id: L0KZ54
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

867904:METHO RS09975
gene id: 867904:METHO_RS09975
uniprot id: L0KXR1
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

867904:METHO RS00765
gene id: 867904:METHO_RS00765
uniprot id: L0KUS4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

867904:METHO RS09345
gene id: 867904:METHO_RS09345
uniprot id: L0L1G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Membrane
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

867904:METHO RS07780
gene id: 867904:METHO_RS07780
uniprot id: L0KXJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

867904:METHO RS03145
gene id: 867904:METHO_RS03145
uniprot id: L0KU11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

867904:METHO RS09225
gene id: 867904:METHO_RS09225
uniprot id: L0KYB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS01240
gene id: 867904:METHO_RS01240
uniprot id: L0KWS6
names: Similarity
messages: Belongs to the UPF0147 family.

867904:METHO RS02350
gene id: 867904:METHO_RS02350
uniprot id: L0KXE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

867904:METHO RS00620
gene id: 867904:METHO_RS00620
uniprot id: L0KSL9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS09670
gene id: 867904:METHO_RS09670
uniprot id: L0KYK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

867904:METHO RS09600
gene id: 867904:METHO_RS09600
uniprot id: L0KXI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

867904:METHO RS13525
gene id: 867904:METHO_RS13525
uniprot id: L0KVP3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

867904:METHO RS09675
gene id: 867904:METHO_RS09675
uniprot id: L0KXJ4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

867904:METHO RS10280
gene id: 867904:METHO_RS10280
uniprot id: L0L1Q1
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS07910
gene id: 867904:METHO_RS07910
uniprot id: L0KYU9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS03535
gene id: 867904:METHO_RS03535
uniprot id: L0KWB0
names: Similarity
messages: Belongs to the FwdC/FmdC family.

867904:METHO RS10175
gene id: 867904:METHO_RS10175
uniprot id: L0KXX7
names: Similarity
messages: Belongs to the UPF0251 family.

867904:METHO RS07915
gene id: 867904:METHO_RS07915
uniprot id: L0KXM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS11010
gene id: 867904:METHO_RS11010
uniprot id: L0L0I4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

867904:METHO RS07790
gene id: 867904:METHO_RS07790
uniprot id: L0L0E3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

867904:METHO RS04580
gene id: 867904:METHO_RS04580
uniprot id: L0KWW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

867904:METHO RS08780
gene id: 867904:METHO_RS08780
uniprot id: L0KX42
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

867904:METHO RS08330
gene id: 867904:METHO_RS08330
uniprot id: L0KWW6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS00145
gene id: 867904:METHO_RS00145
uniprot id: L0KT96
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS08950
gene id: 867904:METHO_RS08950
uniprot id: L0KY51
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

867904:METHO RS10020
gene id: 867904:METHO_RS10020
uniprot id: L0KYS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

867904:METHO RS05290
gene id: 867904:METHO_RS05290
uniprot id: L0KXD7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

867904:METHO RS09765
gene id: 867904:METHO_RS09765
uniprot id: L0KZU6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

867904:METHO RS09135
gene id: 867904:METHO_RS09135
uniprot id: L0L1D2
names: Similarity
messages: Belongs to the pirin family.

867904:METHO RS04930
gene id: 867904:METHO_RS04930
uniprot id: L0KYV8
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS08375
gene id: 867904:METHO_RS08375
uniprot id: L0KXU2
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS07970
gene id: 867904:METHO_RS07970
uniprot id: L0KWQ4
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

867904:METHO RS04555
gene id: 867904:METHO_RS04555
uniprot id: L0KWW1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

867904:METHO RS00815
gene id: 867904:METHO_RS00815
uniprot id: L0KUT4
names: Similarity
messages: Belongs to the UPF0288 family.

867904:METHO RS09720
gene id: 867904:METHO_RS09720
uniprot id: L0KYL3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

867904:METHO RS12430
gene id: 867904:METHO_RS12430
uniprot id: L0L332
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

867904:METHO RS10685
gene id: 867904:METHO_RS10685
uniprot id: L0KY74
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS11145
gene id: 867904:METHO_RS11145
uniprot id: L0L236
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

867904:METHO RS03980
gene id: 867904:METHO_RS03980
uniprot id: L0KVA1
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

867904:METHO RS00005
gene id: 867904:METHO_RS00005
uniprot id: L0KWG8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

867904:METHO RS04945
gene id: 867904:METHO_RS04945
uniprot id: L0KX52
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS01430
gene id: 867904:METHO_RS01430
uniprot id: L0KTW5
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

867904:METHO RS10025
gene id: 867904:METHO_RS10025
uniprot id: L0KXS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

867904:METHO RS05670
gene id: 867904:METHO_RS05670
uniprot id: L0KVF5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

867904:METHO RS04155
gene id: 867904:METHO_RS04155
uniprot id: L0KYE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

867904:METHO RS03460
gene id: 867904:METHO_RS03460
uniprot id: L0KW96
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

867904:METHO RS04830
gene id: 867904:METHO_RS04830
uniprot id: L0KYU0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

867904:METHO RS09735
gene id: 867904:METHO_RS09735
uniprot id: L0L1N5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

867904:METHO RS01640
gene id: 867904:METHO_RS01640
uniprot id: L0KV76
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

867904:METHO RS10105
gene id: 867904:METHO_RS10105
uniprot id: L0L1K0
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

867904:METHO RS04840
gene id: 867904:METHO_RS04840
uniprot id: L0KX29
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

867904:METHO RS03015
gene id: 867904:METHO_RS03015
uniprot id: L0KXT6
names: Similarity
messages: Belongs to the AAA ATPase family.

867904:METHO RS09660
gene id: 867904:METHO_RS09660
uniprot id: L0L1M1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

867904:METHO RS11050
gene id: 867904:METHO_RS11050
uniprot id: L0L0I8
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS01860
gene id: 867904:METHO_RS01860
uniprot id: L0KVC7
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09580
gene id: 867904:METHO_RS09580
uniprot id: L0L190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

867904:METHO RS07775
gene id: 867904:METHO_RS07775
uniprot id: L0KYT0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

867904:METHO RS01770
gene id: 867904:METHO_RS01770
uniprot id: L0KU34
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

867904:METHO RS00210
gene id: 867904:METHO_RS00210
uniprot id: L0KWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

867904:METHO RS03930
gene id: 867904:METHO_RS03930
uniprot id: L0KV90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

867904:METHO RS00040
gene id: 867904:METHO_RS00040
uniprot id: L0KT77
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

867904:METHO RS10855
gene id: 867904:METHO_RS10855
uniprot id: L0L2B9
names: Similarity
messages: Belongs to the peptidase S8 family.

867904:METHO RS01840
gene id: 867904:METHO_RS01840
uniprot id: L0KU50
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS01260
gene id: 867904:METHO_RS01260
uniprot id: L0KSX6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS11595
gene id: 867904:METHO_RS11595
uniprot id: L0L2N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

867904:METHO RS01820
gene id: 867904:METHO_RS01820
uniprot id: L0KT74
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

867904:METHO RS04585
gene id: 867904:METHO_RS04585
uniprot id: L0KVN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

867904:METHO RS00680
gene id: 867904:METHO_RS00680
uniprot id: L0KWH4
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

867904:METHO RS09645
gene id: 867904:METHO_RS09645
uniprot id: L0KYJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

867904:METHO RS04305
gene id: 867904:METHO_RS04305
uniprot id: L0KVH3
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS06525
gene id: 867904:METHO_RS06525
uniprot id: L0L002
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

867904:METHO RS00460
gene id: 867904:METHO_RS00460
uniprot id: L0KTE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

867904:METHO RS05965
gene id: 867904:METHO_RS05965
uniprot id: L0KWF8
names: Similarity
messages: Belongs to the LarC family.

867904:METHO RS04040
gene id: 867904:METHO_RS04040
uniprot id: L0KYL6
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

867904:METHO RS11260
gene id: 867904:METHO_RS11260
uniprot id: L0KZG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

867904:METHO RS03190
gene id: 867904:METHO_RS03190
uniprot id: L0KUW4
names: Similarity
messages: Belongs to the CutA family.

867904:METHO RS11720
gene id: 867904:METHO_RS11720
uniprot id: L0L2Q3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

867904:METHO RS04415
gene id: 867904:METHO_RS04415
uniprot id: L0KYK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

867904:METHO RS06035
gene id: 867904:METHO_RS06035
uniprot id: L0KWH3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS08680
gene id: 867904:METHO_RS08680
uniprot id: L0L151
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

867904:METHO RS09610
gene id: 867904:METHO_RS09610
uniprot id: L0L1L1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

867904:METHO RS04660
gene id: 867904:METHO_RS04660
uniprot id: L0KVP7
names: Similarity
messages: Belongs to the UPF0173 family.

867904:METHO RS02570
gene id: 867904:METHO_RS02570
uniprot id: L0KXL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane

867904:METHO RS07565
gene id: 867904:METHO_RS07565
uniprot id: L0KXF8
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

867904:METHO RS05215
gene id: 867904:METHO_RS05215
uniprot id: L0KZB4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS04825
gene id: 867904:METHO_RS04825
uniprot id: L0KUW8
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS11590
gene id: 867904:METHO_RS11590
uniprot id: L0L2B3
names: Subcellular Location Annotation
messages: Cytoplasm

867904:METHO RS03865
gene id: 867904:METHO_RS03865
uniprot id: L0KYI2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

867904:METHO RS11780
gene id: 867904:METHO_RS11780
uniprot id: L0KZQ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

867904:METHO RS03215
gene id: 867904:METHO_RS03215
uniprot id: L0KUW9
names: Similarity
messages: Belongs to the MtxX family.

867904:METHO RS00110
gene id: 867904:METHO_RS00110
uniprot id: L0KUH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

867904:METHO RS04515
gene id: 867904:METHO_RS04515
uniprot id: L0KUP8
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

867904:METHO RS01385
gene id: 867904:METHO_RS01385
uniprot id: L0KTV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

867904:METHO RS03195
gene id: 867904:METHO_RS03195
uniprot id: L0KU18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

867904:METHO RS06130
gene id: 867904:METHO_RS06130
uniprot id: L0KXS9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

867904:METHO RS07435
gene id: 867904:METHO_RS07435
uniprot id: L0L0I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

867904:METHO RS00305
gene id: 867904:METHO_RS00305
uniprot id: L0KSH3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

867904:METHO RS03860
gene id: 867904:METHO_RS03860
uniprot id: L0KY88
names: Similarity
messages: Belongs to the MCM family.

867904:METHO RS09485
gene id: 867904:METHO_RS09485
uniprot id: L0KZN4
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS10560
gene id: 867904:METHO_RS10560
uniprot id: L0L1U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

867904:METHO RS10770
gene id: 867904:METHO_RS10770
uniprot id: L0L1X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

867904:METHO RS09680
gene id: 867904:METHO_RS09680
uniprot id: L0L1B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS02410
gene id: 867904:METHO_RS02410
uniprot id: L0KVP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

867904:METHO RS01975
gene id: 867904:METHO_RS01975
uniprot id: L0KX70
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

867904:METHO RS00535
gene id: 867904:METHO_RS00535
uniprot id: L0KTF4
names: Similarity
messages: Belongs to the AAA ATPase family.

867904:METHO RS09540
gene id: 867904:METHO_RS09540
uniprot id: L0KYH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS00645
gene id: 867904:METHO_RS00645
uniprot id: L0KSM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS11190
gene id: 867904:METHO_RS11190
uniprot id: L0KYG0
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09940
gene id: 867904:METHO_RS09940
uniprot id: L0KZY3
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

867904:METHO RS04755
gene id: 867904:METHO_RS04755
uniprot id: L0KYS4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

867904:METHO RS00160
gene id: 867904:METHO_RS00160
uniprot id: L0KX52
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS10645
gene id: 867904:METHO_RS10645
uniprot id: L0L0C4
names: Similarity
messages: Belongs to the UPF0166 family.

867904:METHO RS03370
gene id: 867904:METHO_RS03370
uniprot id: L0KY95
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

867904:METHO RS09685
gene id: 867904:METHO_RS09685
uniprot id: L0L1M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

867904:METHO RS10170
gene id: 867904:METHO_RS10170
uniprot id: L0KYX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

867904:METHO RS02165
gene id: 867904:METHO_RS02165
uniprot id: L0KVJ2
names: Subunit
messages: Homotetramer.

867904:METHO RS10700
gene id: 867904:METHO_RS10700
uniprot id: L0L0D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

867904:METHO RS09650
gene id: 867904:METHO_RS09650
uniprot id: L0KXI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

867904:METHO RS08870
gene id: 867904:METHO_RS08870
uniprot id: L0KZA7
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

867904:METHO RS08855
gene id: 867904:METHO_RS08855
uniprot id: L0KX54
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

867904:METHO RS03415
gene id: 867904:METHO_RS03415
uniprot id: L0KU58
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS02200
gene id: 867904:METHO_RS02200
uniprot id: L0KTF2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

867904:METHO RS04855
gene id: 867904:METHO_RS04855
uniprot id: L0KYU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

867904:METHO RS10625
gene id: 867904:METHO_RS10625
uniprot id: L0KZ59
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

867904:METHO RS02465
gene id: 867904:METHO_RS02465
uniprot id: L0KTL3
names: Similarity
messages: Belongs to the UPF0210 family.

867904:METHO RS06270
gene id: 867904:METHO_RS06270
uniprot id: L0KZK6
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

867904:METHO RS00630
gene id: 867904:METHO_RS00630
uniprot id: L0KWS2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS12495
gene id: 867904:METHO_RS12495
uniprot id: L0KZ63
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS02030
gene id: 867904:METHO_RS02030
uniprot id: L0KXG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

867904:METHO RS02210
gene id: 867904:METHO_RS02210
uniprot id: L0KXK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

867904:METHO RS10705
gene id: 867904:METHO_RS10705
uniprot id: L0KZ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

867904:METHO RS08540
gene id: 867904:METHO_RS08540
uniprot id: L0KZ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

867904:METHO RS06570
gene id: 867904:METHO_RS06570
uniprot id: L0KVW0
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS10605
gene id: 867904:METHO_RS10605
uniprot id: L0KY59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS02040
gene id: 867904:METHO_RS02040
uniprot id: L0KU93
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

867904:METHO RS07900
gene id: 867904:METHO_RS07900
uniprot id: L0L0F8
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS10265
gene id: 867904:METHO_RS10265
uniprot id: L0L068
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

867904:METHO RS10860
gene id: 867904:METHO_RS10860
uniprot id: L0L0F7
names: Similarity
messages: Belongs to the Fur family.

867904:METHO RS10245
gene id: 867904:METHO_RS10245
uniprot id: L0KYY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS01375
gene id: 867904:METHO_RS01375
uniprot id: L0KX53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

867904:METHO RS04800
gene id: 867904:METHO_RS04800
uniprot id: L0KUW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

867904:METHO RS01980
gene id: 867904:METHO_RS01980
uniprot id: L0KXF9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

867904:METHO RS08145
gene id: 867904:METHO_RS08145
uniprot id: L0KWT3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

867904:METHO RS02835
gene id: 867904:METHO_RS02835
uniprot id: L0KUQ9
names: Similarity
messages: Belongs to the FBPase class 2 family.

867904:METHO RS02180
gene id: 867904:METHO_RS02180
uniprot id: L0KXB0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

867904:METHO RS07890
gene id: 867904:METHO_RS07890
uniprot id: L0KXL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS07835
gene id: 867904:METHO_RS07835
uniprot id: L0KXK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

867904:METHO RS09620
gene id: 867904:METHO_RS09620
uniprot id: L0KYJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

867904:METHO RS05385
gene id: 867904:METHO_RS05385
uniprot id: L0KXF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

867904:METHO RS09080
gene id: 867904:METHO_RS09080
uniprot id: L0L0Z9
names: Similarity
messages: Belongs to the UPF0285 family.

867904:METHO RS04410
gene id: 867904:METHO_RS04410
uniprot id: L0KUN1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

867904:METHO RS13015
gene id: 867904:METHO_RS13015
uniprot id: L0L0J4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

867904:METHO RS04920
gene id: 867904:METHO_RS04920
uniprot id: L0KX47
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

867904:METHO RS00375
gene id: 867904:METHO_RS00375
uniprot id: L0KUL6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS10885
gene id: 867904:METHO_RS10885
uniprot id: L0L0G1
names: Similarity
messages: Belongs to the UPF0111 family.

867904:METHO RS09170
gene id: 867904:METHO_RS09170
uniprot id: L0KYA0
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

867904:METHO RS09160
gene id: 867904:METHO_RS09160
uniprot id: L0L1D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

867904:METHO RS06610
gene id: 867904:METHO_RS06610
uniprot id: L0L016
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS10875
gene id: 867904:METHO_RS10875
uniprot id: L0L1Z1
names: Similarity
messages: Belongs to the SAICAR synthetase family.

867904:METHO RS03210
gene id: 867904:METHO_RS03210
uniprot id: L0KW53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

867904:METHO RS07995
gene id: 867904:METHO_RS07995
uniprot id: L0KWQ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

867904:METHO RS02170
gene id: 867904:METHO_RS02170
uniprot id: L0KUC0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

867904:METHO RS09690
gene id: 867904:METHO_RS09690
uniprot id: L0KZT0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

867904:METHO RS04130
gene id: 867904:METHO_RS04130
uniprot id: L0KUI2
names: Similarity
messages: Belongs to the PDCD5 family.

867904:METHO RS01495
gene id: 867904:METHO_RS01495
uniprot id: L0KWX6
names: Similarity
messages: Belongs to the glutamate synthase family.

867904:METHO RS00085
gene id: 867904:METHO_RS00085
uniprot id: L0KUH4
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS12290
gene id: 867904:METHO_RS12290
uniprot id: L0KZ16
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09365
gene id: 867904:METHO_RS09365
uniprot id: L0L150
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

867904:METHO RS04060
gene id: 867904:METHO_RS04060
uniprot id: L0KYC8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

867904:METHO RS09425
gene id: 867904:METHO_RS09425
uniprot id: L0L1H9
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS06390
gene id: 867904:METHO_RS06390
uniprot id: L0KZM6
names: Similarity
messages: Belongs to the peptidase M18 family.

867904:METHO RS04080
gene id: 867904:METHO_RS04080
uniprot id: L0KUH1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

867904:METHO RS09730
gene id: 867904:METHO_RS09730
uniprot id: L0L1C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS04625
gene id: 867904:METHO_RS04625
uniprot id: L0KYP4
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS07345
gene id: 867904:METHO_RS07345
uniprot id: L0L061
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

867904:METHO RS01630
gene id: 867904:METHO_RS01630
uniprot id: L0KWZ9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

867904:METHO RS05380
gene id: 867904:METHO_RS05380
uniprot id: L0KZE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

867904:METHO RS09760
gene id: 867904:METHO_RS09760
uniprot id: L0L1P2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

867904:METHO RS07230
gene id: 867904:METHO_RS07230
uniprot id: L0KW91
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

867904:METHO RS04065
gene id: 867904:METHO_RS04065
uniprot id: L0KYL9
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

867904:METHO RS08120
gene id: 867904:METHO_RS08120
uniprot id: L0KWS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

867904:METHO RS12775
gene id: 867904:METHO_RS12775
uniprot id: L0L330
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

867904:METHO RS03910
gene id: 867904:METHO_RS03910
uniprot id: L0KY98
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

867904:METHO RS03450
gene id: 867904:METHO_RS03450
uniprot id: L0KY05
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

867904:METHO RS08690
gene id: 867904:METHO_RS08690
uniprot id: L0KXZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS10890
gene id: 867904:METHO_RS10890
uniprot id: L0KZA0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

867904:METHO RS06465
gene id: 867904:METHO_RS06465
uniprot id: L0KZZ2
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09595
gene id: 867904:METHO_RS09595
uniprot id: L0KYI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

867904:METHO RS12450
gene id: 867904:METHO_RS12450
uniprot id: L0L2U2
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

867904:METHO RS05065
gene id: 867904:METHO_RS05065
uniprot id: L0KZ00
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

867904:METHO RS04695
gene id: 867904:METHO_RS04695
uniprot id: L0KYY5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

867904:METHO RS08140
gene id: 867904:METHO_RS08140
uniprot id: L0KXQ6
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS03735
gene id: 867904:METHO_RS03735
uniprot id: L0KY63
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS05690
gene id: 867904:METHO_RS05690
uniprot id: L0KWA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

867904:METHO RS02510
gene id: 867904:METHO_RS02510
uniprot id: L0KUK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

867904:METHO RS02600
gene id: 867904:METHO_RS02600
uniprot id: L0KXV9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS02335
gene id: 867904:METHO_RS02335
uniprot id: L0KVN2
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS04270
gene id: 867904:METHO_RS04270
uniprot id: L0KYQ7
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

867904:METHO RS04975
gene id: 867904:METHO_RS04975
uniprot id: L0KVV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

867904:METHO RS01320
gene id: 867904:METHO_RS01320
uniprot id: L0KX43
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

867904:METHO RS03790
gene id: 867904:METHO_RS03790
uniprot id: L0KYG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

867904:METHO RS04470
gene id: 867904:METHO_RS04470
uniprot id: L0KYU7
names: Similarity
messages: Belongs to the UPF0280 family.

867904:METHO RS04445
gene id: 867904:METHO_RS04445
uniprot id: L0KYU1
names: Similarity
messages: Belongs to the DMRL synthase family.

867904:METHO RS07305
gene id: 867904:METHO_RS07305
uniprot id: L0KYH1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

867904:METHO RS04170
gene id: 867904:METHO_RS04170
uniprot id: L0KVE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

867904:METHO RS00940
gene id: 867904:METHO_RS00940
uniprot id: L0KUV7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS02620
gene id: 867904:METHO_RS02620
uniprot id: L0KXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

867904:METHO RS11800
gene id: 867904:METHO_RS11800
uniprot id: L0KZR1
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

867904:METHO RS01095
gene id: 867904:METHO_RS01095
uniprot id: L0KX05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

867904:METHO RS03035
gene id: 867904:METHO_RS03035
uniprot id: L0KTZ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

867904:METHO RS08980
gene id: 867904:METHO_RS08980
uniprot id: L0KX76
names: Similarity
messages: Belongs to the UPF0284 family.

867904:METHO RS11005
gene id: 867904:METHO_RS11005
uniprot id: L0L2E3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

867904:METHO RS04645
gene id: 867904:METHO_RS04645
uniprot id: L0KVN9
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS04050
gene id: 867904:METHO_RS04050
uniprot id: L0KVB6
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

867904:METHO RS05975
gene id: 867904:METHO_RS05975
uniprot id: L0KZF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell.

867904:METHO RS11075
gene id: 867904:METHO_RS11075
uniprot id: L0L0J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

867904:METHO RS02265
gene id: 867904:METHO_RS02265
uniprot id: L0KVL5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

867904:METHO RS09640
gene id: 867904:METHO_RS09640
uniprot id: L0KZR8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS01675
gene id: 867904:METHO_RS01675
uniprot id: L0KT47
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

867904:METHO RS09695
gene id: 867904:METHO_RS09695
uniprot id: L0KYK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

867904:METHO RS01340
gene id: 867904:METHO_RS01340
uniprot id: L0KWU5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

867904:METHO RS12380
gene id: 867904:METHO_RS12380
uniprot id: L0L1A2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

867904:METHO RS08360
gene id: 867904:METHO_RS08360
uniprot id: L0L0M5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS11900
gene id: 867904:METHO_RS11900
uniprot id: L0KYT3
names: Similarity
messages: Belongs to the MCM family.

867904:METHO RS07110
gene id: 867904:METHO_RS07110
uniprot id: L0L0B0
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS03810
gene id: 867904:METHO_RS03810
uniprot id: L0KY78
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS03570
gene id: 867904:METHO_RS03570
uniprot id: L0KU84
names: Similarity
messages: Belongs to the ClpA/ClpB family.

867904:METHO RS04360
gene id: 867904:METHO_RS04360
uniprot id: L0KVI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

867904:METHO RS09015
gene id: 867904:METHO_RS09015
uniprot id: L0L1A9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

867904:METHO RS06255
gene id: 867904:METHO_RS06255
uniprot id: L0KXV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

867904:METHO RS02270
gene id: 867904:METHO_RS02270
uniprot id: L0KUD7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

867904:METHO RS00995
gene id: 867904:METHO_RS00995
uniprot id: L0KTN3
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

867904:METHO RS02025
gene id: 867904:METHO_RS02025
uniprot id: L0KX79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

867904:METHO RS00860
gene id: 867904:METHO_RS00860
uniprot id: L0KWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

867904:METHO RS02095
gene id: 867904:METHO_RS02095
uniprot id: L0KTD4
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS03520
gene id: 867904:METHO_RS03520
uniprot id: L0KU76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

867904:METHO RS01140
gene id: 867904:METHO_RS01140
uniprot id: L0KWR1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

867904:METHO RS08100
gene id: 867904:METHO_RS08100
uniprot id: L0L0I6
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

867904:METHO RS01965
gene id: 867904:METHO_RS01965
uniprot id: L0KU78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

867904:METHO RS11655
gene id: 867904:METHO_RS11655
uniprot id: L0KYN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

867904:METHO RS03470
gene id: 867904:METHO_RS03470
uniprot id: L0KU68
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

867904:METHO RS01645
gene id: 867904:METHO_RS01645
uniprot id: L0KU08
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

867904:METHO RS11305
gene id: 867904:METHO_RS11305
uniprot id: L0L2I8
names: Similarity
messages: Belongs to the TPP enzyme family.

867904:METHO RS06965
gene id: 867904:METHO_RS06965
uniprot id: L0KW33
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS11270
gene id: 867904:METHO_RS11270
uniprot id: L0L261
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

867904:METHO RS02550
gene id: 867904:METHO_RS02550
uniprot id: L0KXU8
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09010
gene id: 867904:METHO_RS09010
uniprot id: L0L0Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

867904:METHO RS04205
gene id: 867904:METHO_RS04205
uniprot id: L0KYF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

867904:METHO RS10430
gene id: 867904:METHO_RS10430
uniprot id: L0KZ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

867904:METHO RS02475
gene id: 867904:METHO_RS02475
uniprot id: L0KXQ8
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS12800
gene id: 867904:METHO_RS12800
uniprot id: L0L3C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

867904:METHO RS07945
gene id: 867904:METHO_RS07945
uniprot id: L0KWQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

867904:METHO RS06150
gene id: 867904:METHO_RS06150
uniprot id: L0KZT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS03475
gene id: 867904:METHO_RS03475
uniprot id: L0KY11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

867904:METHO RS09220
gene id: 867904:METHO_RS09220
uniprot id: L0KZH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

867904:METHO RS11090
gene id: 867904:METHO_RS11090
uniprot id: L0L225
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS04035
gene id: 867904:METHO_RS04035
uniprot id: L0KYC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

867904:METHO RS11570
gene id: 867904:METHO_RS11570
uniprot id: L0L2N0
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

867904:METHO RS07470
gene id: 867904:METHO_RS07470
uniprot id: L0KXB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

867904:METHO RS00820
gene id: 867904:METHO_RS00820
uniprot id: L0KTK4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS02035
gene id: 867904:METHO_RS02035
uniprot id: L0KVG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

867904:METHO RS08030
gene id: 867904:METHO_RS08030
uniprot id: L0L0V2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

867904:METHO RS03875
gene id: 867904:METHO_RS03875
uniprot id: L0KV80
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

867904:METHO RS00945
gene id: 867904:METHO_RS00945
uniprot id: L0KTM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

867904:METHO RS03785
gene id: 867904:METHO_RS03785
uniprot id: L0KY73
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

867904:METHO RS10655
gene id: 867904:METHO_RS10655
uniprot id: L0KY69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

867904:METHO RS10235
gene id: 867904:METHO_RS10235
uniprot id: L0L212
names: Similarity
messages: Belongs to the DtxR/MntR family.

867904:METHO RS07250
gene id: 867904:METHO_RS07250
uniprot id: L0KYG1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

867904:METHO RS04145
gene id: 867904:METHO_RS04145
uniprot id: L0KVD6
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

867904:METHO RS02505
gene id: 867904:METHO_RS02505
uniprot id: L0KVT7
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS11280
gene id: 867904:METHO_RS11280
uniprot id: L0L0M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

867904:METHO RS02780
gene id: 867904:METHO_RS02780
uniprot id: L0KVY6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

867904:METHO RS01595
gene id: 867904:METHO_RS01595
uniprot id: L0KTZ8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

867904:METHO RS09950
gene id: 867904:METHO_RS09950
uniprot id: L0KXQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

867904:METHO RS04330
gene id: 867904:METHO_RS04330
uniprot id: L0KWR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

867904:METHO RS00885
gene id: 867904:METHO_RS00885
uniprot id: L0KWW9
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS07365
gene id: 867904:METHO_RS07365
uniprot id: L0KWB9
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

867904:METHO RS04720
gene id: 867904:METHO_RS04720
uniprot id: L0KYY9
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

867904:METHO RS01875
gene id: 867904:METHO_RS01875
uniprot id: L0KX50
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS06110
gene id: 867904:METHO_RS06110
uniprot id: L0KWI3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

867904:METHO RS08195
gene id: 867904:METHO_RS08195
uniprot id: L0KWU3
names: Function
names: Subcellular Location Annotation
messages: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).
messages: Cytoplasm

867904:METHO RS07280
gene id: 867904:METHO_RS07280
uniprot id: L0KYG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

867904:METHO RS09655
gene id: 867904:METHO_RS09655
uniprot id: L0L1A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

867904:METHO RS09970
gene id: 867904:METHO_RS09970
uniprot id: L0KYR5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

867904:METHO RS10000
gene id: 867904:METHO_RS10000
uniprot id: L0KXR6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS03610
gene id: 867904:METHO_RS03610
uniprot id: L0KWC3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

867904:METHO RS05210
gene id: 867904:METHO_RS05210
uniprot id: L0KZ27
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

867904:METHO RS03055
gene id: 867904:METHO_RS03055
uniprot id: L0KW29
names: Subcellular Location Annotation
messages: Cell membrane

867904:METHO RS09175
gene id: 867904:METHO_RS09175
uniprot id: L0KXA7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

867904:METHO RS04285
gene id: 867904:METHO_RS04285
uniprot id: L0KUL0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

867904:METHO RS06565
gene id: 867904:METHO_RS06565
uniprot id: L0KWS4
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

867904:METHO RS06595
gene id: 867904:METHO_RS06595
uniprot id: L0KWS9
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

867904:METHO RS03960
gene id: 867904:METHO_RS03960
uniprot id: L0KUE8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

867904:METHO RS04570
gene id: 867904:METHO_RS04570
uniprot id: L0KYN3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

867904:METHO RS10475
gene id: 867904:METHO_RS10475
uniprot id: L0L0A1
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

867904:METHO RS01025
gene id: 867904:METHO_RS01025
uniprot id: L0KST9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

867904:METHO RS01765
gene id: 867904:METHO_RS01765
uniprot id: L0KVA4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

867904:METHO RS10050
gene id: 867904:METHO_RS10050
uniprot id: L0KXS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

867904:METHO RS07875
gene id: 867904:METHO_RS07875
uniprot id: L0L0S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

867904:METHO RS10985
gene id: 867904:METHO_RS10985
uniprot id: L0L0H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

867904:METHO RS09325
gene id: 867904:METHO_RS09325
uniprot id: L0KZK1
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

867904:METHO RS09215
gene id: 867904:METHO_RS09215
uniprot id: L0L1E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

867904:METHO RS07830
gene id: 867904:METHO_RS07830
uniprot id: L0KYT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

867904:METHO RS10040
gene id: 867904:METHO_RS10040
uniprot id: L0L005
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

867904:METHO RS06935
gene id: 867904:METHO_RS06935
uniprot id: L0KX08
names: Similarity
messages: Belongs to the complex I subunit 3 family.

867904:METHO RS02685
gene id: 867904:METHO_RS02685
uniprot id: L0KUN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

867904:METHO RS03200
gene id: 867904:METHO_RS03200
uniprot id: L0KXW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

867904:METHO RS07615
gene id: 867904:METHO_RS07615
uniprot id: L0KYQ5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS06135
gene id: 867904:METHO_RS06135
uniprot id: L0KWI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

867904:METHO RS02245
gene id: 867904:METHO_RS02245
uniprot id: L0KUD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

867904:METHO RS10940
gene id: 867904:METHO_RS10940
uniprot id: L0KZA9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

867904:METHO RS11385
gene id: 867904:METHO_RS11385
uniprot id: L0KZI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

867904:METHO RS08865
gene id: 867904:METHO_RS08865
uniprot id: L0L182
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

867904:METHO RS02420
gene id: 867904:METHO_RS02420
uniprot id: L0KTK2
names: Similarity
messages: Belongs to the acylphosphatase family.

867904:METHO RS11290
gene id: 867904:METHO_RS11290
uniprot id: L0KYH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

867904:METHO RS02225
gene id: 867904:METHO_RS02225
uniprot id: L0KTF7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS05160
gene id: 867904:METHO_RS05160
uniprot id: L0KZ19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

867904:METHO RS02460
gene id: 867904:METHO_RS02460
uniprot id: L0KUH8
names: Similarity
messages: Belongs to the UPF0237 family.

867904:METHO RS06840
gene id: 867904:METHO_RS06840
uniprot id: L0KW07
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

867904:METHO RS06250
gene id: 867904:METHO_RS06250
uniprot id: L0KZV7
names: Similarity
messages: Belongs to the DEAD box helicase family.

867904:METHO RS01395
gene id: 867904:METHO_RS01395
uniprot id: L0KWV4
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

867904:METHO RS05555
gene id: 867904:METHO_RS05555
uniprot id: L0KVD5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS04705
gene id: 867904:METHO_RS04705
uniprot id: L0KVQ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

867904:METHO RS02715
gene id: 867904:METHO_RS02715
uniprot id: L0KTU4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

867904:METHO RS00550
gene id: 867904:METHO_RS00550
uniprot id: L0KWQ8
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS08945
gene id: 867904:METHO_RS08945
uniprot id: L0KZC0
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

867904:METHO RS09630
gene id: 867904:METHO_RS09630
uniprot id: L0L1A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

867904:METHO RS09710
gene id: 867904:METHO_RS09710
uniprot id: L0L1N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

867904:METHO RS04355
gene id: 867904:METHO_RS04355
uniprot id: L0KWR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

867904:METHO RS10820
gene id: 867904:METHO_RS10820
uniprot id: L0L1Y5
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

867904:METHO RS03615
gene id: 867904:METHO_RS03615
uniprot id: L0KV28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

867904:METHO RS06545
gene id: 867904:METHO_RS06545
uniprot id: L0KVV5
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

867904:METHO RS10725
gene id: 867904:METHO_RS10725
uniprot id: L0L0D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

867904:METHO RS08920
gene id: 867904:METHO_RS08920
uniprot id: L0KZB6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

867904:METHO RS05535
gene id: 867904:METHO_RS05535
uniprot id: L0KZ79
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

867904:METHO RS01880
gene id: 867904:METHO_RS01880
uniprot id: L0KXE0
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS07330
gene id: 867904:METHO_RS07330
uniprot id: L0KYH8
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

867904:METHO RS04480
gene id: 867904:METHO_RS04480
uniprot id: L0KVL1
names: Similarity
messages: Belongs to the glutaredoxin family.

867904:METHO RS11335
gene id: 867904:METHO_RS11335
uniprot id: L0L2J3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

867904:METHO RS08820
gene id: 867904:METHO_RS08820
uniprot id: L0KZ97
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

867904:METHO RS03760
gene id: 867904:METHO_RS03760
uniprot id: L0KY68
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS07375
gene id: 867904:METHO_RS07375
uniprot id: L0L0G7
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS01480
gene id: 867904:METHO_RS01480
uniprot id: L0KV46
names: Similarity
messages: Belongs to the HdrC family.

867904:METHO RS01075
gene id: 867904:METHO_RS01075
uniprot id: L0KTP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

867904:METHO RS04715
gene id: 867904:METHO_RS04715
uniprot id: L0KYR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

867904:METHO RS02710
gene id: 867904:METHO_RS02710
uniprot id: L0KUN7
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

867904:METHO RS01315
gene id: 867904:METHO_RS01315
uniprot id: L0KWT9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS01335
gene id: 867904:METHO_RS01335
uniprot id: L0KSY9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

867904:METHO RS11085
gene id: 867904:METHO_RS11085
uniprot id: L0KYE2
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

867904:METHO RS02730
gene id: 867904:METHO_RS02730
uniprot id: L0KVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

867904:METHO RS06265
gene id: 867904:METHO_RS06265
uniprot id: L0KVR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

867904:METHO RS11250
gene id: 867904:METHO_RS11250
uniprot id: L0L2H9
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

867904:METHO RS01665
gene id: 867904:METHO_RS01665
uniprot id: L0KV82
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

867904:METHO RS08620
gene id: 867904:METHO_RS08620
uniprot id: L0KX15
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

867904:METHO RS10620
gene id: 867904:METHO_RS10620
uniprot id: L0L0C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

867904:METHO RS01550
gene id: 867904:METHO_RS01550
uniprot id: L0KX81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

867904:METHO RS00270
gene id: 867904:METHO_RS00270
uniprot id: L0KUJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

867904:METHO RS08905
gene id: 867904:METHO_RS08905
uniprot id: L0KX63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

867904:METHO RS03110
gene id: 867904:METHO_RS03110
uniprot id: L0KW36
names: Similarity
messages: Belongs to the HsdR family.

867904:METHO RS05070
gene id: 867904:METHO_RS05070
uniprot id: L0KZ90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

867904:METHO RS07225
gene id: 867904:METHO_RS07225
uniprot id: L0KX69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

867904:METHO RS11185
gene id: 867904:METHO_RS11185
uniprot id: L0KZE8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

867904:METHO RS11265
gene id: 867904:METHO_RS11265
uniprot id: L0KYH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

867904:METHO RS09625
gene id: 867904:METHO_RS09625
uniprot id: L0KXI4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

867904:METHO RS13055
gene id: 867904:METHO_RS13055
uniprot id: L0L3G7
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

867904:METHO RS08055
gene id: 867904:METHO_RS08055
uniprot id: L0L0V6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

867904:METHO RS04180
gene id: 867904:METHO_RS04180
uniprot id: L0KYF4
names: Similarity
messages: Belongs to the TrpC family.

867904:METHO RS04785
gene id: 867904:METHO_RS04785
uniprot id: L0KZ05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

867904:METHO RS09870
gene id: 867904:METHO_RS09870
uniprot id: L0KYP2
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

867904:METHO RS01475
gene id: 867904:METHO_RS01475
uniprot id: L0KX68
names: Similarity
messages: Belongs to the HdrB family.

867904:METHO RS02840
gene id: 867904:METHO_RS02840
uniprot id: L0KTW7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

867904:METHO RS00555
gene id: 867904:METHO_RS00555
uniprot id: L0KUN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS10545
gene id: 867904:METHO_RS10545
uniprot id: L0L268
names: Similarity
messages: Belongs to the UPF0235 family.

867904:METHO RS05980
gene id: 867904:METHO_RS05980
uniprot id: L0KZR0
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS08215
gene id: 867904:METHO_RS08215
uniprot id: L0KXR9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

867904:METHO RS01515
gene id: 867904:METHO_RS01515
uniprot id: L0KT19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

867904:METHO RS01410
gene id: 867904:METHO_RS01410
uniprot id: L0KT01
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

867904:METHO RS01435
gene id: 867904:METHO_RS01435
uniprot id: L0KT06
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

867904:METHO RS05650
gene id: 867904:METHO_RS05650
uniprot id: L0KXJ3
names: Similarity
messages: Belongs to the DEAD box helicase family.

867904:METHO RS01945
gene id: 867904:METHO_RS01945
uniprot id: L0KT99
names: Similarity
messages: Belongs to the eIF-2-alpha family.

867904:METHO RS07220
gene id: 867904:METHO_RS07220
uniprot id: L0KYF7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

867904:METHO RS12150
gene id: 867904:METHO_RS12150
uniprot id: L0L2Y4
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS06955
gene id: 867904:METHO_RS06955
uniprot id: L0KY96
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

867904:METHO RS10445
gene id: 867904:METHO_RS10445
uniprot id: L0L252
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

867904:METHO RS12195
gene id: 867904:METHO_RS12195
uniprot id: L0L2N8
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS03720
gene id: 867904:METHO_RS03720
uniprot id: L0KWE0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

867904:METHO RS04485
gene id: 867904:METHO_RS04485
uniprot id: L0KUP3
names: Subcellular Location Annotation
messages: Cytoplasm

867904:METHO RS06815
gene id: 867904:METHO_RS06815
uniprot id: L0KW03
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

867904:METHO RS09200
gene id: 867904:METHO_RS09200
uniprot id: L0KYA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

867904:METHO RS01855
gene id: 867904:METHO_RS01855
uniprot id: L0KXD6
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS03985
gene id: 867904:METHO_RS03985
uniprot id: L0KUF2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

867904:METHO RS09195
gene id: 867904:METHO_RS09195
uniprot id: L0KZH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

867904:METHO RS02295
gene id: 867904:METHO_RS02295
uniprot id: L0KTH2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

867904:METHO RS01745
gene id: 867904:METHO_RS01745
uniprot id: L0KU29
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

867904:METHO RS08835
gene id: 867904:METHO_RS08835
uniprot id: L0L0V9
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

867904:METHO RS10460
gene id: 867904:METHO_RS10460
uniprot id: L0KY34
names: Similarity
messages: Belongs to the TrpF family.

867904:METHO RS03360
gene id: 867904:METHO_RS03360
uniprot id: L0KU49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

867904:METHO RS00715
gene id: 867904:METHO_RS00715
uniprot id: L0KUR4
names: Similarity
messages: Belongs to the PurH family.

867904:METHO RS07235
gene id: 867904:METHO_RS07235
uniprot id: L0L041
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

867904:METHO RS09055
gene id: 867904:METHO_RS09055
uniprot id: L0L0Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

867904:METHO RS01105
gene id: 867904:METHO_RS01105
uniprot id: L0KTQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

867904:METHO RS10455
gene id: 867904:METHO_RS10455
uniprot id: L0KZ26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

867904:METHO RS11160
gene id: 867904:METHO_RS11160
uniprot id: L0KZE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

867904:METHO RS08995
gene id: 867904:METHO_RS08995
uniprot id: L0KZC9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

867904:METHO RS00730
gene id: 867904:METHO_RS00730
uniprot id: L0KWI2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

867904:METHO RS11035
gene id: 867904:METHO_RS11035
uniprot id: L0L217
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

867904:METHO RS00465
gene id: 867904:METHO_RS00465
uniprot id: L0KSJ8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

867904:METHO RS01955
gene id: 867904:METHO_RS01955
uniprot id: L0KXF3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

867904:METHO RS08490
gene id: 867904:METHO_RS08490
uniprot id: L0KZ38
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS07620
gene id: 867904:METHO_RS07620
uniprot id: L0KXH5
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS06025
gene id: 867904:METHO_RS06025
uniprot id: L0KZS0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

867904:METHO RS11220
gene id: 867904:METHO_RS11220
uniprot id: L0L250
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

867904:METHO RS02175
gene id: 867904:METHO_RS02175
uniprot id: L0KTE8
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

867904:METHO RS00200
gene id: 867904:METHO_RS00200
uniprot id: L0KTA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

867904:METHO RS00450
gene id: 867904:METHO_RS00450
uniprot id: L0KWP4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

867904:METHO RS01620
gene id: 867904:METHO_RS01620
uniprot id: L0KU04
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS10490
gene id: 867904:METHO_RS10490
uniprot id: L0L1T7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

867904:METHO RS09775
gene id: 867904:METHO_RS09775
uniprot id: L0KXL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

867904:METHO RS02845
gene id: 867904:METHO_RS02845
uniprot id: L0KXR4
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS00670
gene id: 867904:METHO_RS00670
uniprot id: L0KSM8
names: Similarity
messages: Belongs to the HerA family.

867904:METHO RS02220
gene id: 867904:METHO_RS02220
uniprot id: L0KUC8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

867904:METHO RS04455
gene id: 867904:METHO_RS04455
uniprot id: L0KVK4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS04740
gene id: 867904:METHO_RS04740
uniprot id: L0KX07
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS01120
gene id: 867904:METHO_RS01120
uniprot id: L0KX09
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS04650
gene id: 867904:METHO_RS04650
uniprot id: L0KYP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

867904:METHO RS04165
gene id: 867904:METHO_RS04165
uniprot id: L0KWM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

867904:METHO RS00835
gene id: 867904:METHO_RS00835
uniprot id: L0KWV9
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

867904:METHO RS11845
gene id: 867904:METHO_RS11845
uniprot id: L0KZS1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

867904:METHO RS07810
gene id: 867904:METHO_RS07810
uniprot id: L0KWM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

867904:METHO RS05470
gene id: 867904:METHO_RS05470
uniprot id: L0KZG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

867904:METHO RS02395
gene id: 867904:METHO_RS02395
uniprot id: L0KTJ8
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

867904:METHO RS09450
gene id: 867904:METHO_RS09450
uniprot id: L0L166
names: Similarity
messages: Belongs to the GARS family.

867904:METHO RS00840
gene id: 867904:METHO_RS00840
uniprot id: L0KUT9
names: Similarity
messages: Belongs to the AOR/FOR family.

867904:METHO RS04340
gene id: 867904:METHO_RS04340
uniprot id: L0KUL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

867904:METHO RS04565
gene id: 867904:METHO_RS04565
uniprot id: L0KUQ8
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS00725
gene id: 867904:METHO_RS00725
uniprot id: L0KSN7
names: Subcellular Location Annotation
messages: Cell membrane

867904:METHO RS10980
gene id: 867904:METHO_RS10980
uniprot id: L0L2D9
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS11275
gene id: 867904:METHO_RS11275
uniprot id: L0L2I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

867904:METHO RS06555
gene id: 867904:METHO_RS06555
uniprot id: L0L009
names: Similarity
messages: Belongs to the HsdR family.

867904:METHO RS05280
gene id: 867904:METHO_RS05280
uniprot id: L0KV83
names: Cofactor
messages: Binds 1 zinc ion per subunit.

867904:METHO RS02585
gene id: 867904:METHO_RS02585
uniprot id: L0KUL9
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS02785
gene id: 867904:METHO_RS02785
uniprot id: L0KUQ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

867904:METHO RS05540
gene id: 867904:METHO_RS05540
uniprot id: L0KZH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

867904:METHO RS00905
gene id: 867904:METHO_RS00905
uniprot id: L0KWL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

867904:METHO RS03260
gene id: 867904:METHO_RS03260
uniprot id: L0KW61
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

867904:METHO RS04545
gene id: 867904:METHO_RS04545
uniprot id: L0KYM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

867904:METHO RS09350
gene id: 867904:METHO_RS09350
uniprot id: L0KZK8
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

867904:METHO RS07215
gene id: 867904:METHO_RS07215
uniprot id: L0L0D0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

867904:METHO RS04405
gene id: 867904:METHO_RS04405
uniprot id: L0KVJ4
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

867904:METHO RS12200
gene id: 867904:METHO_RS12200
uniprot id: L0L2Z3
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS01180
gene id: 867904:METHO_RS01180
uniprot id: L0KTR1
names: Subcellular Location Annotation
messages: Cell membrane

867904:METHO RS04350
gene id: 867904:METHO_RS04350
uniprot id: L0KYS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

867904:METHO RS10015
gene id: 867904:METHO_RS10015
uniprot id: L0L001
names: Similarity
messages: Belongs to the MtrH family.

867904:METHO RS04550
gene id: 867904:METHO_RS04550
uniprot id: L0KYV9
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

867904:METHO RS10085
gene id: 867904:METHO_RS10085
uniprot id: L0L1J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

867904:METHO RS10895
gene id: 867904:METHO_RS10895
uniprot id: L0KYB0
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

867904:METHO RS00920
gene id: 867904:METHO_RS00920
uniprot id: L0KTM3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS09635
gene id: 867904:METHO_RS09635
uniprot id: L0L1L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS07955
gene id: 867904:METHO_RS07955
uniprot id: L0L0T9
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

867904:METHO RS09235
gene id: 867904:METHO_RS09235
uniprot id: L0L124
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

867904:METHO RS11445
gene id: 867904:METHO_RS11445
uniprot id: L0L289
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

867904:METHO RS04190
gene id: 867904:METHO_RS04190
uniprot id: L0KWN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

867904:METHO RS07510
gene id: 867904:METHO_RS07510
uniprot id: L0KYM8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

867904:METHO RS09205
gene id: 867904:METHO_RS09205
uniprot id: L0KXB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

867904:METHO RS01380
gene id: 867904:METHO_RS01380
uniprot id: L0KV27
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

867904:METHO RS04965
gene id: 867904:METHO_RS04965
uniprot id: L0KZ44
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

867904:METHO RS05190
gene id: 867904:METHO_RS05190
uniprot id: L0KZB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

867904:METHO RS12220
gene id: 867904:METHO_RS12220
uniprot id: L0L2Z5
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09615
gene id: 867904:METHO_RS09615
uniprot id: L0KZR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

867904:METHO RS04185
gene id: 867904:METHO_RS04185
uniprot id: L0KYN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

867904:METHO RS08975
gene id: 867904:METHO_RS08975
uniprot id: L0KY56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

867904:METHO RS05320
gene id: 867904:METHO_RS05320
uniprot id: L0KW47
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

867904:METHO RS06730
gene id: 867904:METHO_RS06730
uniprot id: L0L035
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

867904:METHO RS01310
gene id: 867904:METHO_RS01310
uniprot id: L0KSY5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS02915
gene id: 867904:METHO_RS02915
uniprot id: L0KXS4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

867904:METHO RS02815
gene id: 867904:METHO_RS02815
uniprot id: L0KTW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

867904:METHO RS09025
gene id: 867904:METHO_RS09025
uniprot id: L0KY66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

867904:METHO RS10435
gene id: 867904:METHO_RS10435
uniprot id: L0KY29
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

867904:METHO RS07795
gene id: 867904:METHO_RS07795
uniprot id: L0L0R4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

867904:METHO RS08415
gene id: 867904:METHO_RS08415
uniprot id: L0KXU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

867904:METHO RS03970
gene id: 867904:METHO_RS03970
uniprot id: L0KYK1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

867904:METHO RS05060
gene id: 867904:METHO_RS05060
uniprot id: L0KV39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

867904:METHO RS03175
gene id: 867904:METHO_RS03175
uniprot id: L0KXV6
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09445
gene id: 867904:METHO_RS09445
uniprot id: L0KXF1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS09430
gene id: 867904:METHO_RS09430
uniprot id: L0KZM4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS04275
gene id: 867904:METHO_RS04275
uniprot id: L0KWQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS01810
gene id: 867904:METHO_RS01810
uniprot id: L0KVB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

867904:METHO RS06470
gene id: 867904:METHO_RS06470
uniprot id: L0KXZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS04700
gene id: 867904:METHO_RS04700
uniprot id: L0KWZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

867904:METHO RS09455
gene id: 867904:METHO_RS09455
uniprot id: L0L1I4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS10990
gene id: 867904:METHO_RS10990
uniprot id: L0KZB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

867904:METHO RS08875
gene id: 867904:METHO_RS08875
uniprot id: L0KY35
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS08915
gene id: 867904:METHO_RS08915
uniprot id: L0L194
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

867904:METHO RS01290
gene id: 867904:METHO_RS01290
uniprot id: L0KWT4
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

867904:METHO RS00015
gene id: 867904:METHO_RS00015
uniprot id: L0KT75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

867904:METHO RS06330
gene id: 867904:METHO_RS06330
uniprot id: L0KZL6
names: Similarity
messages: Belongs to the HsdR family.

867904:METHO RS00400
gene id: 867904:METHO_RS00400
uniprot id: L0KUM0
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

867904:METHO RS02700
gene id: 867904:METHO_RS02700
uniprot id: L0KXX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

867904:METHO RS02960
gene id: 867904:METHO_RS02960
uniprot id: L0KY22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

867904:METHO RS04560
gene id: 867904:METHO_RS04560
uniprot id: L0KVM5
names: Function
messages: Part of a potassium transport system.

867904:METHO RS09050
gene id: 867904:METHO_RS09050
uniprot id: L0KX86
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

867904:METHO RS05855
gene id: 867904:METHO_RS05855
uniprot id: L0KVJ1
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

867904:METHO RS08475
gene id: 867904:METHO_RS08475
uniprot id: L0KWY8
names: Similarity
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.

867904:METHO RS00175
gene id: 867904:METHO_RS00175
uniprot id: L0KSD3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS06435
gene id: 867904:METHO_RS06435
uniprot id: L0KVT6
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

867904:METHO RS07825
gene id: 867904:METHO_RS07825
uniprot id: L0L0R9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

867904:METHO RS05325
gene id: 867904:METHO_RS05325
uniprot id: L0KV92
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

867904:METHO RS03465
gene id: 867904:METHO_RS03465
uniprot id: L0KV07
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

867904:METHO RS05240
gene id: 867904:METHO_RS05240
uniprot id: L0KZB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

867904:METHO RS04210
gene id: 867904:METHO_RS04210
uniprot id: L0KYP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

867904:METHO RS08230
gene id: 867904:METHO_RS08230
uniprot id: L0L0X9
names: Similarity
messages: Belongs to the thymidylate kinase family.

867904:METHO RS00690
gene id: 867904:METHO_RS00690
uniprot id: L0KUR1
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS08380
gene id: 867904:METHO_RS08380
uniprot id: L0KWX5
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS11105
gene id: 867904:METHO_RS11105
uniprot id: L0KZD4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS12265
gene id: 867904:METHO_RS12265
uniprot id: L0L2Q5
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS06240
gene id: 867904:METHO_RS06240
uniprot id: L0KVR0
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

867904:METHO RS09795
gene id: 867904:METHO_RS09795
uniprot id: L0KYM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

867904:METHO RS04015
gene id: 867904:METHO_RS04015
uniprot id: L0KYL1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

867904:METHO RS01425
gene id: 867904:METHO_RS01425
uniprot id: L0KV36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

867904:METHO RS01100
gene id: 867904:METHO_RS01100
uniprot id: L0KUY1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS01230
gene id: 867904:METHO_RS01230
uniprot id: L0KTS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

867904:METHO RS07210
gene id: 867904:METHO_RS07210
uniprot id: L0L037
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

867904:METHO RS14000
gene id: 867904:METHO_RS14000
uniprot id: L0L154
names: Similarity
messages: Belongs to the intimin/invasin family.

867904:METHO RS07930
gene id: 867904:METHO_RS07930
uniprot id: L0L0T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

867904:METHO RS04125
gene id: 867904:METHO_RS04125
uniprot id: L0KVD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS09230
gene id: 867904:METHO_RS09230
uniprot id: L0KXB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

867904:METHO RS07800
gene id: 867904:METHO_RS07800
uniprot id: L0KYT4
names: Similarity
messages: Belongs to the MEMO1 family.

867904:METHO RS01985
gene id: 867904:METHO_RS01985
uniprot id: L0KVF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

867904:METHO RS03400
gene id: 867904:METHO_RS03400
uniprot id: L0KY99
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS02920
gene id: 867904:METHO_RS02920
uniprot id: L0KY17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

867904:METHO RS10960
gene id: 867904:METHO_RS10960
uniprot id: L0L0H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

867904:METHO RS00850
gene id: 867904:METHO_RS00850
uniprot id: L0KSQ9
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

867904:METHO RS09890
gene id: 867904:METHO_RS09890
uniprot id: L0KZX3
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS10575
gene id: 867904:METHO_RS10575
uniprot id: L0KZ50
names: Similarity
messages: Belongs to the UPF0215 family.

867904:METHO RS03600
gene id: 867904:METHO_RS03600
uniprot id: L0KY36
names: Similarity
messages: Belongs to the UPF0758 family.

867904:METHO RS02825
gene id: 867904:METHO_RS02825
uniprot id: L0KXZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

867904:METHO RS10030
gene id: 867904:METHO_RS10030
uniprot id: L0L1I6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

867904:METHO RS07745
gene id: 867904:METHO_RS07745
uniprot id: L0L0Q7
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

867904:METHO RS11480
gene id: 867904:METHO_RS11480
uniprot id: L0L0R2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

867904:METHO RS02060
gene id: 867904:METHO_RS02060
uniprot id: L0KVH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

867904:METHO RS02280
gene id: 867904:METHO_RS02280
uniprot id: L0KXL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

867904:METHO RS00215
gene id: 867904:METHO_RS00215
uniprot id: L0KWK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS04500
gene id: 867904:METHO_RS04500
uniprot id: L0KWV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

867904:METHO RS10485
gene id: 867904:METHO_RS10485
uniprot id: L0KY38
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

867904:METHO RS10525
gene id: 867904:METHO_RS10525
uniprot id: L0L0A6
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

867904:METHO RS03235
gene id: 867904:METHO_RS03235
uniprot id: L0KW57
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS03445
gene id: 867904:METHO_RS03445
uniprot id: L0KV03
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

867904:METHO RS02635
gene id: 867904:METHO_RS02635
uniprot id: L0KUM8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

867904:METHO RS08245
gene id: 867904:METHO_RS08245
uniprot id: L0KWV3
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

867904:METHO RS05085
gene id: 867904:METHO_RS05085
uniprot id: L0KV45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

867904:METHO RS11505
gene id: 867904:METHO_RS11505
uniprot id: L0L0R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

867904:METHO RS09590
gene id: 867904:METHO_RS09590
uniprot id: L0KZQ8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

867904:METHO RS11405
gene id: 867904:METHO_RS11405
uniprot id: L0L0P9
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

867904:METHO RS00275
gene id: 867904:METHO_RS00275
uniprot id: L0KTB9
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

867904:METHO RS02615
gene id: 867904:METHO_RS02615
uniprot id: L0KTS7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

867904:METHO RS11200
gene id: 867904:METHO_RS11200
uniprot id: L0L2H0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

867904:METHO RS02985
gene id: 867904:METHO_RS02985
uniprot id: L0KUT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

867904:METHO RS05100
gene id: 867904:METHO_RS05100
uniprot id: L0KXA5
names: Similarity
messages: Belongs to the HepT RNase toxin family.

867904:METHO RS13960
gene id: 867904:METHO_RS13960
uniprot id: L0KZW6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

867904:METHO RS03725
gene id: 867904:METHO_RS03725
uniprot id: L0KV49
names: Similarity
messages: Belongs to the DtxR/MntR family.

867904:METHO RS03490
gene id: 867904:METHO_RS03490
uniprot id: L0KV11
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

867904:METHO RS08345
gene id: 867904:METHO_RS08345
uniprot id: L0KZ12
names: Similarity
messages: Belongs to the Fur family.

867904:METHO RS10480
gene id: 867904:METHO_RS10480
uniprot id: L0KZ31
names: Caution
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS11585
gene id: 867904:METHO_RS11585
uniprot id: L0KYM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

867904:METHO RS09030
gene id: 867904:METHO_RS09030
uniprot id: L0KX82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

867904:METHO RS12825
gene id: 867904:METHO_RS12825
uniprot id: L0L3C7
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

867904:METHO RS06185
gene id: 867904:METHO_RS06185
uniprot id: L0KWJ9
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS07975
gene id: 867904:METHO_RS07975
uniprot id: L0L0H0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

867904:METHO RS07500
gene id: 867904:METHO_RS07500
uniprot id: L0L090
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS03965
gene id: 867904:METHO_RS03965
uniprot id: L0KYA8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS02775
gene id: 867904:METHO_RS02775
uniprot id: L0KXY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

867904:METHO RS10835
gene id: 867904:METHO_RS10835
uniprot id: L0KZ91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

867904:METHO RS01485
gene id: 867904:METHO_RS01485
uniprot id: L0KTX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

867904:METHO RS09125
gene id: 867904:METHO_RS09125
uniprot id: L0KX98
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS01110
gene id: 867904:METHO_RS01110
uniprot id: L0KSV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

867904:METHO RS11795
gene id: 867904:METHO_RS11795
uniprot id: L0L0X0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

867904:METHO RS12020
gene id: 867904:METHO_RS12020
uniprot id: L0L2K0
names: Subunit
messages: Monomer.

867904:METHO RS09960
gene id: 867904:METHO_RS09960
uniprot id: L0L1T5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

867904:METHO RS00640
gene id: 867904:METHO_RS00640
uniprot id: L0KTH1
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS04765
gene id: 867904:METHO_RS04765
uniprot id: L0KX12
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

867904:METHO RS10955
gene id: 867904:METHO_RS10955
uniprot id: L0L2D5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

867904:METHO RS02355
gene id: 867904:METHO_RS02355
uniprot id: L0KXM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

867904:METHO RS00665
gene id: 867904:METHO_RS00665
uniprot id: L0KTH6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS07335
gene id: 867904:METHO_RS07335
uniprot id: L0KX90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

867904:METHO RS07360
gene id: 867904:METHO_RS07360
uniprot id: L0KX95
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

867904:METHO RS10795
gene id: 867904:METHO_RS10795
uniprot id: L0L1Y0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

867904:METHO RS02140
gene id: 867904:METHO_RS02140
uniprot id: L0KVI7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

867904:METHO RS06510
gene id: 867904:METHO_RS06510
uniprot id: L0KWR5
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

867904:METHO RS12860
gene id: 867904:METHO_RS12860
uniprot id: L0L349
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS09605
gene id: 867904:METHO_RS09605
uniprot id: L0L199
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

867904:METHO RS10760
gene id: 867904:METHO_RS10760
uniprot id: L0KZ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

867904:METHO RS10735
gene id: 867904:METHO_RS10735
uniprot id: L0KY83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

867904:METHO RS05625
gene id: 867904:METHO_RS05625
uniprot id: L0KXI8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

867904:METHO RS05465
gene id: 867904:METHO_RS05465
uniprot id: L0KZ67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

867904:METHO RS01415
gene id: 867904:METHO_RS01415
uniprot id: L0KWW0
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

867904:METHO RS01885
gene id: 867904:METHO_RS01885
uniprot id: L0KVD2
names: Similarity
messages: Belongs to the UPF0145 family.

867904:METHO RS09550
gene id: 867904:METHO_RS09550
uniprot id: L0L186
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

867904:METHO RS10465
gene id: 867904:METHO_RS10465
uniprot id: L0L1T3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS09240
gene id: 867904:METHO_RS09240
uniprot id: L0L1E9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS07805
gene id: 867904:METHO_RS07805
uniprot id: L0KXK2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

867904:METHO RS07440
gene id: 867904:METHO_RS07440
uniprot id: L0KYJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

867904:METHO RS06915
gene id: 867904:METHO_RS06915
uniprot id: L0KW21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

867904:METHO RS09725
gene id: 867904:METHO_RS09725
uniprot id: L0KXK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

867904:METHO RS07820
gene id: 867904:METHO_RS07820
uniprot id: L0L0E5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

867904:METHO RS03050
gene id: 867904:METHO_RS03050
uniprot id: L0KY33
names: Similarity
messages: Belongs to the DNA photolyase family.

867904:METHO RS10915
gene id: 867904:METHO_RS10915
uniprot id: L0KZA5
names: Similarity
messages: Belongs to the SUI1 family.

867904:METHO RS04160
gene id: 867904:METHO_RS04160
uniprot id: L0KYN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

867904:METHO RS08105
gene id: 867904:METHO_RS08105
uniprot id: L0L0W0
names: Similarity
messages: Belongs to the UPF0212 family.

867904:METHO RS11600
gene id: 867904:METHO_RS11600
uniprot id: L0L0T2
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

867904:METHO RS11425
gene id: 867904:METHO_RS11425
uniprot id: L0L2K6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS05220
gene id: 867904:METHO_RS05220
uniprot id: L0KXC7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS10370
gene id: 867904:METHO_RS10370
uniprot id: L0KY15
names: Similarity
messages: Belongs to the UPF0107 family.

867904:METHO RS00955
gene id: 867904:METHO_RS00955
uniprot id: L0KWM8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS01750
gene id: 867904:METHO_RS01750
uniprot id: L0KT60
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS00845
gene id: 867904:METHO_RS00845
uniprot id: L0KTK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

867904:METHO RS02115
gene id: 867904:METHO_RS02115
uniprot id: L0KUA9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

867904:METHO RS02490
gene id: 867904:METHO_RS02490
uniprot id: L0KTN4
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS07495
gene id: 867904:METHO_RS07495
uniprot id: L0KWE7
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

867904:METHO RS08585
gene id: 867904:METHO_RS08585
uniprot id: L0L133
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

867904:METHO RS06880
gene id: 867904:METHO_RS06880
uniprot id: L0KY81
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS05125
gene id: 867904:METHO_RS05125
uniprot id: L0KW14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

867904:METHO RS07895
gene id: 867904:METHO_RS07895
uniprot id: L0KWN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS04440
gene id: 867904:METHO_RS04440
uniprot id: L0KYL0
names: Similarity
messages: Belongs to the DMRL synthase family.

867904:METHO RS00350
gene id: 867904:METHO_RS00350
uniprot id: L0KUL2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

867904:METHO RS09470
gene id: 867904:METHO_RS09470
uniprot id: L0KXF7
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

867904:METHO RS12110
gene id: 867904:METHO_RS12110
uniprot id: L0KZY1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS09865
gene id: 867904:METHO_RS09865
uniprot id: L0KZW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

867904:METHO RS03625
gene id: 867904:METHO_RS03625
uniprot id: L0KY40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

867904:METHO RS09705
gene id: 867904:METHO_RS09705
uniprot id: L0L1B7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

867904:METHO RS04375
gene id: 867904:METHO_RS04375
uniprot id: L0KWS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

867904:METHO RS01995
gene id: 867904:METHO_RS01995
uniprot id: L0KTB1
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

867904:METHO RS01090
gene id: 867904:METHO_RS01090
uniprot id: L0KWQ1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

867904:METHO RS04950
gene id: 867904:METHO_RS04950
uniprot id: L0KVV3
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS01205
gene id: 867904:METHO_RS01205
uniprot id: L0KTR5
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

867904:METHO RS09955
gene id: 867904:METHO_RS09955
uniprot id: L0L1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

867904:METHO RS04970
gene id: 867904:METHO_RS04970
uniprot id: L0KX58
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

867904:METHO RS05475
gene id: 867904:METHO_RS05475
uniprot id: L0KXG6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

867904:METHO RS10035
gene id: 867904:METHO_RS10035
uniprot id: L0L1V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

867904:METHO RS05390
gene id: 867904:METHO_RS05390
uniprot id: L0KW56
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS08965
gene id: 867904:METHO_RS08965
uniprot id: L0L1A1
names: Similarity
messages: Belongs to the ZPR1 family.

867904:METHO RS11175
gene id: 867904:METHO_RS11175
uniprot id: L0L2G6
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

867904:METHO RS03550
gene id: 867904:METHO_RS03550
uniprot id: L0KY26
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

867904:METHO RS01580
gene id: 867904:METHO_RS01580
uniprot id: L0KWZ1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

867904:METHO RS09535
gene id: 867904:METHO_RS09535
uniprot id: L0KZP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

867904:METHO RS00735
gene id: 867904:METHO_RS00735
uniprot id: L0KWU0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

867904:METHO RS09460
gene id: 867904:METHO_RS09460
uniprot id: L0KZM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

867904:METHO RS01255
gene id: 867904:METHO_RS01255
uniprot id: L0KTS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

867904:METHO RS10130
gene id: 867904:METHO_RS10130
uniprot id: L0L1L8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

867904:METHO RS08385
gene id: 867904:METHO_RS08385
uniprot id: L0L0N0
names: Similarity
messages: Belongs to the class-I fumarase family.

867904:METHO RS06885
gene id: 867904:METHO_RS06885
uniprot id: L0KWZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

867904:METHO RS10925
gene id: 867904:METHO_RS10925
uniprot id: L0L1Z8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

867904:METHO RS01990
gene id: 867904:METHO_RS01990
uniprot id: L0KU83
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

867904:METHO RS00455
gene id: 867904:METHO_RS00455
uniprot id: L0KUM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

867904:METHO RS09700
gene id: 867904:METHO_RS09700
uniprot id: L0KXJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

867904:METHO RS00280
gene id: 867904:METHO_RS00280
uniprot id: L0KSG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

867904:METHO RS08695
gene id: 867904:METHO_RS08695
uniprot id: L0KX27
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS12285
gene id: 867904:METHO_RS12285
uniprot id: L0L021
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS01635
gene id: 867904:METHO_RS01635
uniprot id: L0KX92
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

867904:METHO RS02830
gene id: 867904:METHO_RS02830
uniprot id: L0KVZ4
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

867904:METHO RS04450
gene id: 867904:METHO_RS04450
uniprot id: L0KWU2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

867904:METHO RS02340
gene id: 867904:METHO_RS02340
uniprot id: L0KUF0
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

867904:METHO RS11370
gene id: 867904:METHO_RS11370
uniprot id: L0L2J7
names: Similarity
messages: Belongs to the peptidase S49 family.

867904:METHO RS02425
gene id: 867904:METHO_RS02425
uniprot id: L0KXG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS08115
gene id: 867904:METHO_RS08115
uniprot id: L0KXQ2
names: Similarity
messages: Belongs to the HerA family.

867904:METHO RS04595
gene id: 867904:METHO_RS04595
uniprot id: L0KYN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

867904:METHO RS04980
gene id: 867904:METHO_RS04980
uniprot id: L0KUZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

867904:METHO RS03170
gene id: 867904:METHO_RS03170
uniprot id: L0KU15
names: Similarity
messages: Belongs to the threonine synthase family.

867904:METHO RS07985
gene id: 867904:METHO_RS07985
uniprot id: L0KYW1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

867904:METHO RS04055
gene id: 867904:METHO_RS04055
uniprot id: L0KUG8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

867904:METHO RS02595
gene id: 867904:METHO_RS02595
uniprot id: L0KXL8
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

867904:METHO RS11110
gene id: 867904:METHO_RS11110
uniprot id: L0KYE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

867904:METHO RS02795
gene id: 867904:METHO_RS02795
uniprot id: L0KXQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

867904:METHO RS10250
gene id: 867904:METHO_RS10250
uniprot id: L0KXZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

867904:METHO RS04910
gene id: 867904:METHO_RS04910
uniprot id: L0KYV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

867904:METHO RS04120
gene id: 867904:METHO_RS04120
uniprot id: L0KWL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

867904:METHO RS08590
gene id: 867904:METHO_RS08590
uniprot id: U3GLG9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

867904:METHO RS05135
gene id: 867904:METHO_RS05135
uniprot id: L0KZ14
names: Similarity
messages: Belongs to the UPF0047 family.

867904:METHO RS00055
gene id: 867904:METHO_RS00055
uniprot id: L0KWH6
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS04885
gene id: 867904:METHO_RS04885
uniprot id: L0KZ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

867904:METHO RS02415
gene id: 867904:METHO_RS02415
uniprot id: L0KUG7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS03245
gene id: 867904:METHO_RS03245
uniprot id: L0KU26
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS06740
gene id: 867904:METHO_RS06740
uniprot id: L0KWW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

867904:METHO RS11055
gene id: 867904:METHO_RS11055
uniprot id: L0KZC6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS02090
gene id: 867904:METHO_RS02090
uniprot id: L0KUA4
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

867904:METHO RS13175
gene id: 867904:METHO_RS13175
uniprot id: L0L1N8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

867904:METHO RS08335
gene id: 867904:METHO_RS08335
uniprot id: L0L0M1
names: Similarity
messages: Belongs to the catalase family.

867904:METHO RS00190
gene id: 867904:METHO_RS00190
uniprot id: L0KWJ7
names: Similarity
messages: Belongs to the monomethylamine methyltransferase family.

867904:METHO RS06795
gene id: 867904:METHO_RS06795
uniprot id: L0KVZ8
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS00575
gene id: 867904:METHO_RS00575
uniprot id: U3GK80
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS01970
gene id: 867904:METHO_RS01970
uniprot id: L0KTA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

867904:METHO RS12615
gene id: 867904:METHO_RS12615
uniprot id: L0L1F8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

867904:METHO RS02640
gene id: 867904:METHO_RS02640
uniprot id: L0KTT2
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

867904:METHO RS08610
gene id: 867904:METHO_RS08610
uniprot id: L0KZ60
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

867904:METHO RS09880
gene id: 867904:METHO_RS09880
uniprot id: L0L1F9
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

867904:METHO RS02240
gene id: 867904:METHO_RS02240
uniprot id: L0KVK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

867904:METHO RS11000
gene id: 867904:METHO_RS11000
uniprot id: L0L211
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

867904:METHO RS00470
gene id: 867904:METHO_RS00470
uniprot id: L0KWF0
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

867904:METHO RS08860
gene id: 867904:METHO_RS08860
uniprot id: L0L0W3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

867904:METHO RS11815
gene id: 867904:METHO_RS11815
uniprot id: L0L2F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

867904:METHO RS11685
gene id: 867904:METHO_RS11685
uniprot id: L0KYP0
names: Similarity
messages: Belongs to the UPF0201 family.

867904:METHO RS01285
gene id: 867904:METHO_RS01285
uniprot id: L0KSY0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

867904:METHO RS04140
gene id: 867904:METHO_RS04140
uniprot id: L0KWM0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

867904:METHO RS11460
gene id: 867904:METHO_RS11460
uniprot id: L0KZJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

867904:METHO RS03555
gene id: 867904:METHO_RS03555
uniprot id: L0KYC6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS08560
gene id: 867904:METHO_RS08560
uniprot id: L0L128
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

867904:METHO RS02720
gene id: 867904:METHO_RS02720
uniprot id: L0KXP1
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS12215
gene id: 867904:METHO_RS12215
uniprot id: L0L2P4
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS02235
gene id: 867904:METHO_RS02235
uniprot id: L0KXK5
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

867904:METHO RS01625
gene id: 867904:METHO_RS01625
uniprot id: L0KT38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

867904:METHO RS01670
gene id: 867904:METHO_RS01670
uniprot id: L0KU13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

867904:METHO RS09275
gene id: 867904:METHO_RS09275
uniprot id: L0KYC1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

867904:METHO RS01740
gene id: 867904:METHO_RS01740
uniprot id: L0KV99
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

867904:METHO RS08470
gene id: 867904:METHO_RS08470
uniprot id: L0KXV3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

867904:METHO RS04000
gene id: 867904:METHO_RS04000
uniprot id: L0KWJ0
names: Similarity
messages: Belongs to the Ahb/Nir family.

867904:METHO RS06995
gene id: 867904:METHO_RS06995
uniprot id: L0L086
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

867904:METHO RS09665
gene id: 867904:METHO_RS09665
uniprot id: L0KZS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

867904:METHO RS04775
gene id: 867904:METHO_RS04775
uniprot id: L0KUV6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

867904:METHO RS07570
gene id: 867904:METHO_RS07570
uniprot id: L0KWI0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

867904:METHO RS03575
gene id: 867904:METHO_RS03575
uniprot id: L0KY31
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

867904:METHO RS02275
gene id: 867904:METHO_RS02275
uniprot id: L0KTG8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS03420
gene id: 867904:METHO_RS03420
uniprot id: L0KY00
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

867904:METHO RS03405
gene id: 867904:METHO_RS03405
uniprot id: L0KW87
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

867904:METHO RS00365
gene id: 867904:METHO_RS00365
uniprot id: L0KWD3
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

867904:METHO RS09210
gene id: 867904:METHO_RS09210
uniprot id: L0L119
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

867904:METHO RS02370
gene id: 867904:METHO_RS02370
uniprot id: L0KTJ2
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS02515
gene id: 867904:METHO_RS02515
uniprot id: L0KTQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

867904:METHO RS08240
gene id: 867904:METHO_RS08240
uniprot id: L0KXS3
names: Similarity
messages: Belongs to the HisA/HisF family.

867904:METHO RS09545
gene id: 867904:METHO_RS09545
uniprot id: L0KXH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

867904:METHO RS10255
gene id: 867904:METHO_RS10255
uniprot id: L0L1P6
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS01325
gene id: 867904:METHO_RS01325
uniprot id: L0KV17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

867904:METHO RS01175
gene id: 867904:METHO_RS01175
uniprot id: L0KUZ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

867904:METHO RS11550
gene id: 867904:METHO_RS11550
uniprot id: L0L2M5
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

867904:METHO RS08900
gene id: 867904:METHO_RS08900
uniprot id: L0KY41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

867904:METHO RS06930
gene id: 867904:METHO_RS06930
uniprot id: L0KY91
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

867904:METHO RS10155
gene id: 867904:METHO_RS10155
uniprot id: L0L1M9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS00780
gene id: 867904:METHO_RS00780
uniprot id: L0KWJ2
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09005
gene id: 867904:METHO_RS09005
uniprot id: L0KX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

867904:METHO RS06790
gene id: 867904:METHO_RS06790
uniprot id: L0KWX4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

867904:METHO RS11080
gene id: 867904:METHO_RS11080
uniprot id: L0KZD1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

867904:METHO RS04045
gene id: 867904:METHO_RS04045
uniprot id: L0KWK0
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

867904:METHO RS00205
gene id: 867904:METHO_RS00205
uniprot id: L0KSF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

867904:METHO RS06370
gene id: 867904:METHO_RS06370
uniprot id: L0KZX5
names: Subcellular Location Annotation
messages: Membrane

867904:METHO RS09715
gene id: 867904:METHO_RS09715
uniprot id: L0KZT6
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

867904:METHO RS10150
gene id: 867904:METHO_RS10150
uniprot id: L0KXX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

867904:METHO RS08815
gene id: 867904:METHO_RS08815
uniprot id: L0L173
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

867904:METHO RS04990
gene id: 867904:METHO_RS04990
uniprot id: L0KZ49
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

867904:METHO RS11870
gene id: 867904:METHO_RS11870
uniprot id: L0KYS9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

867904:METHO RS00070
gene id: 867904:METHO_RS00070
uniprot id: L0KSD3
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

867904:METHO RS07070
gene id: 867904:METHO_RS07070
uniprot id: L0KW55
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

867904:METHO RS02660
gene id: 867904:METHO_RS02660
uniprot id: L0KUN0
names: Similarity
messages: Belongs to the UPF0179 family.

867904:METHO RS07475
gene id: 867904:METHO_RS07475
uniprot id: L0KWE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

867904:METHO RS09895
gene id: 867904:METHO_RS09895
uniprot id: L0KYP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

867904:METHO RS03655
gene id: 867904:METHO_RS03655
uniprot id: L0KYE3
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

867904:METHO RS11810
gene id: 867904:METHO_RS11810
uniprot id: L0KYR1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

867904:METHO RS02250
gene id: 867904:METHO_RS02250
uniprot id: L0KTG4
names: Similarity
messages: Belongs to the PspA/IM30 family.