8364:irf6.2
gene id: 8364:irf6.2
uniprot id: A0A803KIF7
uniprot id: A0A8J0SLB5
uniprot id: A0A8J0SMS1
uniprot id: F7B9E6
uniprot id: Q5BL51
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:senp5
gene id: 8364:senp5
uniprot id: A0A6I8PXC2
uniprot id: F6ZX71
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.
messages: nucleolus

8364:hsf3
gene id: 8364:hsf3
uniprot id: Q28DZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8364:hlx
gene id: 8364:hlx
uniprot id: A0A8J0QRR0
uniprot id: A0A8J0R4I6
uniprot id: F6SKP4
names: Subcellular Location Annotation
messages: Nucleus

8364:vps16
gene id: 8364:vps16
uniprot id: Q6DIM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

8364:med1l
gene id: 8364:med1l
uniprot id: A0A803J8R5
uniprot id: A0A8J0SQR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

8364:jpt2
gene id: 8364:jpt2
uniprot id: A0A6I8PKV3
uniprot id: B4F6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

8364:wdr48
gene id: 8364:wdr48
uniprot id: Q05B17
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Cytoplasm
messages: Late endosome
messages: Lysosome
messages: Nucleus
messages: Regulator of deubiquitinating complexes, which acts as a strong activator of usp1, usp12 and usp46. Enhances the usp1-mediated deubiquitination of fancd2; usp1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing usp12. Together with rad51ap1, promotes DNA repair by stimulating rad51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for usp1-mediated deubiquitination of fancd2 and stimulation of rad51-mediated homologous recombination: both wdr48/uaf1 and rad51ap1 have coordinated role in DNA-binding during these processes. Together with atad5 and by regulating usp1 activity, has a role in pcna-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated pcna. Together with atad5, has a role in recruiting rad51 to stalled forks during replication stress.
messages: The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46.

8364:fads1
gene id: 8364:fads1
uniprot id: A0A6I8QSG1
uniprot id: A0A8J0R097
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

8364:adipor2
gene id: 8364:adipor2
uniprot id: A0A803J440
uniprot id: A0A803JZS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8364:pbx3
gene id: 8364:pbx3
uniprot id: A0A6I8Q4K3
uniprot id: A0A8J0R5K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

8364:LOC100486384
gene id: 8364:LOC100486384
uniprot id: A0A5S6KTE9
uniprot id: F6U264
uniprot id: F6U6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle

8364:camk1
gene id: 8364:camk1
uniprot id: Q5BL60
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC116411774
gene id: 8364:LOC116411774
uniprot id: A0A8J1JRJ1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:chst9l.4
gene id: 8364:chst9l.4
uniprot id: A0A6I8RAL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:mtmr3
gene id: 8364:mtmr3
uniprot id: A0A6I8R8A9
uniprot id: A0A6I8SUG8
uniprot id: A0A8J1IPL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

8364:trpm4
gene id: 8364:trpm4
uniprot id: A0A8J0QP05
uniprot id: A0A8J0R1I2
uniprot id: A0A8J0R3I9
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100135389
gene id: 8364:LOC100135389
uniprot id: A0A8J1JL03
names: Subcellular Location Annotation
messages: Membrane

8364:wif1
gene id: 8364:wif1
uniprot id: F6RKP1
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cep63
gene id: 8364:cep63
uniprot id: A0A803J758
uniprot id: A0A8J1JPF3
names: Similarity
messages: Belongs to the CEP63 family.

8364:rxfp3
gene id: 8364:rxfp3
uniprot id: A0A8J0QT76
uniprot id: F6V946
uniprot id: F7BZS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
messages: Cell membrane
messages: Membrane

8364:LOC100485134
gene id: 8364:LOC100485134
uniprot id: F7C6D9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:cpne7
gene id: 8364:cpne7
uniprot id: A0A6I8QQ62
names: Similarity
messages: Belongs to the copine family.

8364:chmp1b
gene id: 8364:chmp1b
uniprot id: Q6DF27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Endosome
messages: Late endosome membrane
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.
messages: cytosol

8364:hamp
gene id: 8364:hamp
uniprot id: A1YWG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

8364:seh1l
gene id: 8364:seh1l
uniprot id: A0A6I8RCF3
uniprot id: A0A6I8S811
uniprot id: Q5U4Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). Probably part of the GATOR complex.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore
messages: nuclear pore complex

8364:eif3b
gene id: 8364:eif3b
uniprot id: A0A8J0PIE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

8364:cwc15
gene id: 8364:cwc15
uniprot id: B0JYY8
uniprot id: Q0VFP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC15 family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing as component of the spliceosome.
messages: Nucleus

8364:wdr12
gene id: 8364:wdr12
uniprot id: A0A8J0SWP9
uniprot id: Q5BJ90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, composed of bop1, pes1 and wdr12. The complex is held together by bop1, which interacts with pes1 via its N-terminal domain and with wdr12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with mdn1 (via VWFA/MIDAS domain).
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

8364:acy3
gene id: 8364:acy3
uniprot id: A0A8J1J5E3
uniprot id: Q5BJ91
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules.

8364:tmlhe
gene id: 8364:tmlhe
uniprot id: A4IHQ2
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

8364:eif1ax
gene id: 8364:eif1ax
uniprot id: Q6GLB2
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

8364:LOC100489081
gene id: 8364:LOC100489081
uniprot id: A0A8J1JC74
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8364:rnmt
gene id: 8364:rnmt
uniprot id: Q28FT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.
messages: Nucleus

8364:LOC116411634
gene id: 8364:LOC116411634
uniprot id: A0A6I8QAK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116408577
gene id: 8364:LOC116408577
uniprot id: A0A8J1J2G2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:taf10
gene id: 8364:taf10
uniprot id: A0A803JJV9
uniprot id: A0A8J0PJE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus

8364:adssl1
gene id: 8364:adssl1
uniprot id: Q6DIW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.

8364:nfx1
gene id: 8364:nfx1
uniprot id: A0A8J1JNA5
uniprot id: A0A8J1JNA7
uniprot id: A0A8J1JQR7
uniprot id: A0A8J1JS10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

8364:rhcg
gene id: 8364:rhcg
uniprot id: A0A6I8SZE0
uniprot id: A0A8J0SF71
uniprot id: A0A8J1J718
uniprot id: A0A8J1J719
uniprot id: Q6WRY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Functions as an ammonia transporter.
messages: Homotrimer.
messages: Membrane

8364:slc44a5
gene id: 8364:slc44a5
uniprot id: A0A6I8Q9T1
uniprot id: A0A8J1JCT9
uniprot id: A0A8J1JCU4
uniprot id: A0A8J1JCV1
uniprot id: A0A8J1JFA4
uniprot id: A0A8J1JGC2
uniprot id: B0JZD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

8364:pigm
gene id: 8364:pigm
uniprot id: A0A8J1JQ71
uniprot id: A0A8J1JRH3
uniprot id: Q66IJ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity).
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

8364:LOC116411739
gene id: 8364:LOC116411739
uniprot id: A0A8J1JV22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8364:atp9a
gene id: 8364:atp9a
uniprot id: Q6P4Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:g6pc.2
gene id: 8364:g6pc.2
uniprot id: A8WH23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

8364:LOC100494645
gene id: 8364:LOC100494645
uniprot id: A0A803JAD9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:nfkb2
gene id: 8364:nfkb2
uniprot id: A0A8J0SS56
uniprot id: A0A8J0STJ0
uniprot id: Q6DF61
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:LOC100485994
gene id: 8364:LOC100485994
uniprot id: A0A8J0QUM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sde2
gene id: 8364:sde2
uniprot id: Q07G43
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (By similarity). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (By similarity).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (By similarity). May recruit CACTIN to the spliceosome (By similarity).
messages: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity).
messages: The PIP-box (PCNA interacting peptide) motif mediates both the interaction with PCNA and cleavage of the SDE2 precursor by a deubiquitinating enzyme.
messages: The SAP domain is necessary for specific binding to DNA.
messages: The propeptide displays a ubiquitin-like fold.
messages: Upon binding to PCNA, the N-terminal UBL (ubiquitin-like) propeptide is cleaved at Gly-71 by an unidentified deubiquitinating enzyme; the resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner.

8364:sfxn2
gene id: 8364:sfxn2
uniprot id: A0A6I8QM64
uniprot id: A0A8J0SQQ2
uniprot id: F6X6B9
uniprot id: Q5XGE6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

8364:arl8b
gene id: 8364:arl8b
uniprot id: A0A6I8SH59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8364:ehd2
gene id: 8364:ehd2
uniprot id: Q569E0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

8364:LOC116412276
gene id: 8364:LOC116412276
uniprot id: A0A803JJ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:katnb1
gene id: 8364:katnb1
uniprot id: Q6NVM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with katna1. This interaction enhances the microtubule binding and severing activity of katna1 and also targets this activity to the centrosome.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

8364:t2r42
gene id: 8364:t2r42
uniprot id: Q2AB45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:coa5
gene id: 8364:coa5
uniprot id: Q28CA1
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

8364:LOC100497914
gene id: 8364:LOC100497914
uniprot id: A0A8J1JE89
names: Subcellular Location Annotation
messages: Secreted

8364:med12
gene id: 8364:med12
uniprot id: A0A6I8PL47
uniprot id: A0A8J0SW97
uniprot id: A0A8J1ISA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

8364:kti12
gene id: 8364:kti12
uniprot id: A0A6I8SBI7
uniprot id: B7ZTH7
names: Similarity
messages: Belongs to the KTI12 family.

8364:gpc3
gene id: 8364:gpc3
uniprot id: A0A6I8SBK0
uniprot id: A0A8J1INN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

8364:glp2r
gene id: 8364:glp2r
uniprot id: A0A803J9T5
names: Subcellular Location Annotation
messages: Membrane

8364:sbno1
gene id: 8364:sbno1
uniprot id: A0A6I8QF00
uniprot id: A0A8J0T122
uniprot id: F6YBA0
names: Similarity
messages: Belongs to the SBNO family.

8364:LOC108644783
gene id: 8364:LOC108644783
uniprot id: A0A8J1JTK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:mpp5
gene id: 8364:mpp5
uniprot id: A0A6I8PY89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: tight junction

8364:cabin1
gene id: 8364:cabin1
uniprot id: A0A6I8RJW7
uniprot id: A0A8J1IRH1
uniprot id: A0A8J1ITV4
uniprot id: A0A8J1IUP1
uniprot id: F6XDS7
names: Subcellular Location Annotation
messages: Nucleus

8364:stard4
gene id: 8364:stard4
uniprot id: F6X1W5
names: Similarity
messages: Belongs to the N-CoR nuclear receptor corepressors family.

8364:nppb
gene id: 8364:nppb
uniprot id: A0A7D9NLJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

8364:LOC101735193
gene id: 8364:LOC101735193
uniprot id: A0A8J1JTN2
uniprot id: A0A8J1JXG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:chd3
gene id: 8364:chd3
uniprot id: A0A6I8RL94
uniprot id: A0A8J0QXL8
uniprot id: A0A8J1JC12
uniprot id: A0A8J1JEF7
uniprot id: F6PUX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

8364:fam120c
gene id: 8364:fam120c
uniprot id: A0A6I8RBX3
uniprot id: A0A8J1ILA1
uniprot id: A0A8J1IN99
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

8364:ptgs1
gene id: 8364:ptgs1
uniprot id: A0A6I8SVS9
uniprot id: F6PNE5
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mrps12
gene id: 8364:mrps12
uniprot id: A0A8J0T652
uniprot id: Q28F98
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

8364:fut6
gene id: 8364:fut6
uniprot id: A0A6I8PJR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8364:ciao2a
gene id: 8364:ciao2a
uniprot id: F6PJX5
names: Similarity
messages: Belongs to the MIP18 family.

8364:LOC100485630
gene id: 8364:LOC100485630
uniprot id: A0A8J1IQS9
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

8364:calml4
gene id: 8364:calml4
uniprot id: Q5XGC7
names: Similarity
messages: Belongs to the calmodulin family.

8364:LOC100496109
gene id: 8364:LOC100496109
uniprot id: A0A6I8SYM6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100485358
gene id: 8364:LOC100485358
uniprot id: F6PY92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8364:tmem45a
gene id: 8364:tmem45a
uniprot id: F6ZRP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

8364:rapgef2
gene id: 8364:rapgef2
uniprot id: A0A6I8QRJ5
uniprot id: A0A8J0SBR1
uniprot id: A0A8J0SBS1
uniprot id: A0A8J0SDR5
uniprot id: A0A8J0SEL7
uniprot id: A0A8J0SEM2
uniprot id: A0A8J0SER9
uniprot id: A0A8J0SET1
uniprot id: A0A8J1J4S8
uniprot id: Q08BU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAPGEF2 family.
messages: Cell junction
messages: Endosome
messages: Late endosome
messages: perinuclear region

8364:gabpa
gene id: 8364:gabpa
uniprot id: A0A803KI95
uniprot id: F6UXC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:tpr
gene id: 8364:tpr
uniprot id: A0A6I8SXN0
names: Similarity
messages: Belongs to the TPR family.

8364:LOC100486739
gene id: 8364:LOC100486739
uniprot id: A0A8J0QQH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gtf3c5
gene id: 8364:gtf3c5
uniprot id: A0A6I8RZA6
uniprot id: A0A8J0SVF7
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100490855
gene id: 8364:LOC100490855
uniprot id: A0A8J1JHW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

8364:sec23b
gene id: 8364:sec23b
uniprot id: Q28DM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8364:LOC101733691
gene id: 8364:LOC101733691
uniprot id: A0A8J0R599
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Target cell membrane

8364:mccc2
gene id: 8364:mccc2
uniprot id: Q5BKM8
names: Similarity
messages: Belongs to the AccD/PCCB family.

8364:myo5c
gene id: 8364:myo5c
uniprot id: A0A6I8R1J1
uniprot id: A0A7D9NJM0
uniprot id: A0A8J1JB10
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:coq10b
gene id: 8364:coq10b
uniprot id: Q28GY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

8364:tet2
gene id: 8364:tet2
uniprot id: A0A803JD48
uniprot id: A0A8J0QP75
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

8364:ttc30a
gene id: 8364:ttc30a
uniprot id: A0A8J1JR22
uniprot id: A4IHR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

8364:LOC108648285
gene id: 8364:LOC108648285
uniprot id: A0A8J0T5G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:il18
gene id: 8364:il18
uniprot id: A0A8J1JX39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

8364:minpp1
gene id: 8364:minpp1
uniprot id: A0A7D9N0D2
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

8364:c9orf64
gene id: 8364:c9orf64
uniprot id: F7A4U0
uniprot id: Q5BJ80
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

8364:LOC116410798
gene id: 8364:LOC116410798
uniprot id: A0A8J1JM66
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100490793
gene id: 8364:LOC100490793
uniprot id: A0A8J0QYD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:pglyrp2
gene id: 8364:pglyrp2
uniprot id: A8QN48
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

8364:atp1a1
gene id: 8364:atp1a1
uniprot id: Q6P1S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8364:LOC548945
gene id: 8364:LOC548945
uniprot id: A0A8J0T090
uniprot id: B1H1D5
uniprot id: F6RI56
uniprot id: Q28FS1
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

8364:slc25a32
gene id: 8364:slc25a32
uniprot id: A0A8J1JN35
uniprot id: A9ULD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:arpp19
gene id: 8364:arpp19
uniprot id: Q28GU6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Interacts (when phosphorylated at Ser-67) with ppp2r2d.
messages: Phosphorylation at Ser-67 by gwl during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A.
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).

8364:ccdc85a
gene id: 8364:ccdc85a
uniprot id: A0A8J0QSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

8364:unc93a.2
gene id: 8364:unc93a.2
uniprot id: A0A6I8PPW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

8364:p4ha2
gene id: 8364:p4ha2
uniprot id: A0A6I8SPS1
uniprot id: A0A8J0SI76
uniprot id: Q66KA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8364:shank2
gene id: 8364:shank2
uniprot id: A0A6I8Q109
uniprot id: A0A6I8QHK2
uniprot id: A0A6I8RKX3
uniprot id: A0A6I8T0E0
uniprot id: A0A803KIM5
uniprot id: A0A8J1JCI8
uniprot id: A0A8J1JCJ2
uniprot id: A0A8J1JG19
uniprot id: F6ZPP7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynaptic density

8364:raf1
gene id: 8364:raf1
uniprot id: A0A803JXH9
uniprot id: Q28GW9
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

8364:myo6
gene id: 8364:myo6
uniprot id: A0A6I8RL33
uniprot id: A0A6I8S0P9
uniprot id: A0A6I8SDP6
uniprot id: A0A8J0R474
uniprot id: A0A8J1JKX7
uniprot id: A0A8J1JKX9
uniprot id: A0A8J1JKY2
uniprot id: A0A8J1JKY3
uniprot id: A0A8J1JKY8
uniprot id: A0A8J1JNC9
uniprot id: A0A8J1JPJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: filopodium
messages: microvillus

8364:f2
gene id: 8364:f2
uniprot id: Q5FVW1
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

8364:ndufa11
gene id: 8364:ndufa11
uniprot id: A0A8J0S7W0
uniprot id: B3DM83
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8364:caprin2
gene id: 8364:caprin2
uniprot id: F6QR57
names: Similarity
messages: Belongs to the caprin family.

8364:ctnna1
gene id: 8364:ctnna1
uniprot id: F7DHT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: cytoskeleton

8364:rsph9
gene id: 8364:rsph9
uniprot id: Q6DFN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flagellar radial spoke RSP9 family.
messages: Component of the axonemal radial spoke head which plays an important role in ciliary motility (By similarity). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity).
messages: cilium axoneme
messages: flagellum
messages: kinocilium

8364:LOC101732936
gene id: 8364:LOC101732936
uniprot id: A0A803KAL2
uniprot id: A0A8J1IZ28
uniprot id: A0A8J1IZ38
uniprot id: A0A8J1IZ48
uniprot id: A0A8J1J1H4
uniprot id: A0A8J1J1H9
uniprot id: A0A8J1J2C6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sart1
gene id: 8364:sart1
uniprot id: A0A6I8PWL8
uniprot id: F6X8I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

8364:me2
gene id: 8364:me2
uniprot id: Q5EC53
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

8364:atrnl1
gene id: 8364:atrnl1
uniprot id: A0A8J1JYH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:lypd6b
gene id: 8364:lypd6b
uniprot id: A0A6I8PST8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cd40lg
gene id: 8364:cd40lg
uniprot id: A0A803KAB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

8364:osr2
gene id: 8364:osr2
uniprot id: F7D8N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8364:echs1
gene id: 8364:echs1
uniprot id: Q6GLG0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8364:LOC100488285
gene id: 8364:LOC100488285
uniprot id: A0A8J0QZ65
names: Subcellular Location Annotation
messages: Membrane

8364:nsf
gene id: 8364:nsf
uniprot id: A0A8J0SC23
uniprot id: Q0IJ19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

8364:dusp4
gene id: 8364:dusp4
uniprot id: Q28F83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

8364:abcc1
gene id: 8364:abcc1
uniprot id: A0A6I8QSY5
uniprot id: A0A7D9NK67
uniprot id: A0A8J0QC75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

8364:ssh2
gene id: 8364:ssh2
uniprot id: A0A6I8R0T2
uniprot id: A0A6I8R1R1
uniprot id: A0A8J0QWA7
uniprot id: A0A8J0QYE2
uniprot id: A0A8J0R0X3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

8364:tm4sf5
gene id: 8364:tm4sf5
uniprot id: F6RRT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:LOC105945182
gene id: 8364:LOC105945182
uniprot id: A0A8J1JJ51
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100490841
gene id: 8364:LOC100490841
uniprot id: A0A8J1JBX4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:grk3
gene id: 8364:grk3
uniprot id: A0A6I8S283
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8364:qtrt2
gene id: 8364:qtrt2
uniprot id: A0A8J1J1X2
uniprot id: Q28DX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Heterodimer of a catalytic subunit qtrt1 and an accessory subunit qtrt2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

8364:xpo4
gene id: 8364:xpo4
uniprot id: A0A803K9E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

8364:tmem59l
gene id: 8364:tmem59l
uniprot id: B2GUE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:tasor
gene id: 8364:tasor
uniprot id: A0A803KK55
uniprot id: A0A8J0R3Y6
uniprot id: F6ZRE3
names: Similarity
messages: Belongs to the TASOR family.

8364:ccni2
gene id: 8364:ccni2
uniprot id: A0A8J1J6C6
uniprot id: A4IIX7
names: Similarity
messages: Belongs to the cyclin family.

8364:hhip
gene id: 8364:hhip
uniprot id: Q6DIG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:lhx2
gene id: 8364:lhx2
uniprot id: A0A1B8YA12
uniprot id: A0A803K5A2
names: Subcellular Location Annotation
messages: Nucleus

8364:asah2
gene id: 8364:asah2
uniprot id: B3DM04
names: Similarity
messages: Belongs to the neutral ceramidase family.

8364:eif4g2
gene id: 8364:eif4g2
uniprot id: A0A8J1JFS6
uniprot id: Q6DIH1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

8364:kif24
gene id: 8364:kif24
uniprot id: A0A6I8Q1R6
uniprot id: A0A8J1J1C5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:cdo1
gene id: 8364:cdo1
uniprot id: Q6P896
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

8364:ppif
gene id: 8364:ppif
uniprot id: A0A8J0QFX8
uniprot id: Q66JH4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:atf4
gene id: 8364:atf4
uniprot id: Q6GLH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

8364:dicer1
gene id: 8364:dicer1
uniprot id: A0A8J1IMX6
uniprot id: B3DLA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. Dicer subfamily.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of dicer1, ago2 and tarbp2; dicer1 and tarbp2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto ago2. Note that the trimeric RLC/miRLC is also referred to as RISC (By similarity).
messages: Cytoplasm
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity).
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

8364:tubgcp4
gene id: 8364:tubgcp4
uniprot id: A0A6I8RAR2
uniprot id: Q05AR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

8364:cfap73
gene id: 8364:cfap73
uniprot id: B0BMJ2
names: Similarity
messages: Belongs to the CFAP73 family.

8364:ppib
gene id: 8364:ppib
uniprot id: Q28G13
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:cryga.2
gene id: 8364:cryga.2
uniprot id: A0A8J0T636
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC100485036
gene id: 8364:LOC100485036
uniprot id: A0A8J0QT67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:odr4
gene id: 8364:odr4
uniprot id: A0A8J0R2S8
uniprot id: A0A8J0T0K6
uniprot id: F6RIS9
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

8364:myo9a
gene id: 8364:myo9a
uniprot id: A0A6I8RJ35
uniprot id: A0A6I8SV20
uniprot id: A0A8J0SUA1
uniprot id: F7AFM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Membrane
messages: Synapse
messages: growth cone

8364:bace1
gene id: 8364:bace1
uniprot id: F7ABF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

8364:grpel1
gene id: 8364:grpel1
uniprot id: Q5BJ46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

8364:slitrk6
gene id: 8364:slitrk6
uniprot id: F6ZGX3
names: Similarity
messages: Belongs to the SLITRK family.

8364:LOC100494882
gene id: 8364:LOC100494882
uniprot id: A0A8J0R8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116411996
gene id: 8364:LOC116411996
uniprot id: A0A8J1JUF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100488911
gene id: 8364:LOC100488911
uniprot id: A0A8J0QYE3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:lpcat4
gene id: 8364:lpcat4
uniprot id: A0A8J0SCG3
uniprot id: Q28C60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity).
messages: Endoplasmic reticulum membrane

8364:cntf
gene id: 8364:cntf
uniprot id: A0A8J1JYM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

8364:mdn1
gene id: 8364:mdn1
uniprot id: A0A6I8SCR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

8364:dnm1
gene id: 8364:dnm1
uniprot id: A0A6I8R9C9
uniprot id: A0A6I8RXJ8
uniprot id: A0A6I8SNW8
uniprot id: A0A6I8SRA9
uniprot id: A0A8J0QI56
uniprot id: A0A8J1IL44
uniprot id: A0A8J1IL47
uniprot id: A0A8J1IL48
uniprot id: A0A8J1IL52
uniprot id: A0A8J1IL55
uniprot id: A0A8J1IL57
uniprot id: A0A8J1IL62
uniprot id: A0A8J1IL64
uniprot id: A0A8J1IL69
uniprot id: A0A8J1IN48
uniprot id: A0A8J1IN55
uniprot id: A0A8J1INS5
uniprot id: A0A8J1INT1
uniprot id: A0A8J1INU1
uniprot id: A0A8J1INU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

8364:nr5a1
gene id: 8364:nr5a1
uniprot id: A0A6I8RA71
uniprot id: B9WZB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

8364:cxorf56
gene id: 8364:cxorf56
uniprot id: Q6P338
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEEP1 family.
messages: Cytoplasm
messages: Nucleus
messages: Stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity). Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1 oligomers (By similarity).

8364:fdxr
gene id: 8364:fdxr
uniprot id: A0A803KGG1
uniprot id: F6XUJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

8364:cog1
gene id: 8364:cog1
uniprot id: A0A6I8QLR4
uniprot id: F6RI12
names: Similarity
messages: Belongs to the COG1 family.

8364:LOC116409581
gene id: 8364:LOC116409581
uniprot id: A0A8J1J8I3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cdc20b
gene id: 8364:cdc20b
uniprot id: A0A6I8PMD9
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

8364:rspo1
gene id: 8364:rspo1
uniprot id: B2GUL2
names: Similarity
messages: Belongs to the R-spondin family.

8364:LOC100498105
gene id: 8364:LOC100498105
uniprot id: A0A8J0SW38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:fbxl5
gene id: 8364:fbxl5
uniprot id: A0A803K1B5
uniprot id: Q5XGI3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of ireb2/irp2. Upon high iron and oxygen level, it specifically recognizes and binds ireb2/irp2, promoting its ubiquitination and degradation by the proteasome (By similarity).
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
messages: The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded (By similarity).
messages: Ubiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor (By similarity).
messages: perinuclear region

8364:LOC101733182
gene id: 8364:LOC101733182
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:abat
gene id: 8364:abat
uniprot id: B2GUT2
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer; disulfide-linked.

8364:rtn1
gene id: 8364:rtn1
uniprot id: A7MC64
uniprot id: A8WGE1
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
messages: Membrane
messages: Nucleus

8364:lmx1b.2
gene id: 8364:lmx1b.2
uniprot id: F7CT16
names: Subcellular Location Annotation
messages: Nucleus

8364:hsd11b1l
gene id: 8364:hsd11b1l
uniprot id: A4IGM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Secreted

8364:creg1
gene id: 8364:creg1
uniprot id: A0A8J0QR34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

8364:sft2d3
gene id: 8364:sft2d3
uniprot id: Q28FF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

8364:krt222
gene id: 8364:krt222
uniprot id: A0A1B8Y9F5
names: Similarity
messages: Belongs to the intermediate filament family.

8364:LOC116406532
gene id: 8364:LOC116406532
uniprot id: A0A8J1ILX7
names: Similarity
messages: Belongs to the cyclin family.

8364:il17d
gene id: 8364:il17d
uniprot id: A0A6I8RHS6
uniprot id: B0BML6
uniprot id: F7AM55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Belongs to the cytochrome P450 family.
messages: Secreted

8364:lef1
gene id: 8364:lef1
uniprot id: A0A6I8RA13
uniprot id: A0A8J0QGW0
uniprot id: A0A8J0T1T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

8364:tax1bp1
gene id: 8364:tax1bp1
uniprot id: Q6P3P1
names: Domain
names: Function
messages: May have an anti-apoptotic activity.
messages: The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.

8364:homeobox100496651-provisional
gene id: 8364:homeobox100496651-provisional
uniprot id: A0A6I8S867
names: Subcellular Location Annotation
messages: Nucleus

8364:mzt2b
gene id: 8364:mzt2b
uniprot id: Q28DB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOZART2 family.
messages: Part of the gamma-tubulin complex. Interacts with TUBG1 (By similarity).
messages: centrosome
messages: spindle

8364:ctnnal1
gene id: 8364:ctnnal1
uniprot id: A0A6I8SJF0
uniprot id: A4IIR4
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

8364:mettl6
gene id: 8364:mettl6
uniprot id: A4IJ22
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

8364:svep1
gene id: 8364:svep1
uniprot id: A0A6I8QCW2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:eva1c
gene id: 8364:eva1c
uniprot id: A0A803J8E2
uniprot id: A0A8J0QZ17
names: Similarity
messages: Belongs to the EVA1 family.

8364:snrpc
gene id: 8364:snrpc
uniprot id: B0JYS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins snrnp70/U1-70K, snrpa/U1-A and snrpc/U1-C. snrpc/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus

8364:ccdc172
gene id: 8364:ccdc172
uniprot id: A0A6I8PLZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

8364:cyct
gene id: 8364:cyct
uniprot id: A0A8J1IVG0
uniprot id: Q640U4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

8364:duoxa1
gene id: 8364:duoxa1
uniprot id: A0A8J1JA83
uniprot id: Q0P4G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane
messages: Possible role in maturation and transport from the endoplasmic reticulum to the plasma membrane of functional dual oxidase.

8364:LOC100494536
gene id: 8364:LOC100494536
uniprot id: A0A8J1IYZ0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:ano3
gene id: 8364:ano3
uniprot id: A0A8J1JHE7
uniprot id: F6ZLE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

8364:tas2r13
gene id: 8364:tas2r13
uniprot id: A0A803KIY5
uniprot id: F6T8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:LOC101733556
gene id: 8364:LOC101733556
uniprot id: A0A6I8RD63
uniprot id: F7A6Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Belongs to the MAGUK family.
messages: Membrane

8364:grwd1
gene id: 8364:grwd1
uniprot id: F6Z3Y6
names: Subcellular Location Annotation
messages: Nucleus

8364:igf3
gene id: 8364:igf3
uniprot id: A0A803KGX6
uniprot id: A0A8J1JUG4
uniprot id: F7CZB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

8364:vax1
gene id: 8364:vax1
uniprot id: A0A803JYH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

8364:rgn
gene id: 8364:rgn
uniprot id: Q6DF62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Binds 1 divalent metal cation per subunit. Most active with Zn(2+) and Mn(2+) ions. The physiological cofactor is most likely Ca(2+) or Mg(2+).
messages: Cytoplasm
messages: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).

8364:LOC100494223
gene id: 8364:LOC100494223
uniprot id: A0A803JAF7
uniprot id: A0A803JEL4
uniprot id: A0A8J1J570
names: Similarity
messages: Belongs to the S-100 family.

8364:gngt1
gene id: 8364:gngt1
uniprot id: A4IIB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:mief1
gene id: 8364:mief1
uniprot id: Q501R1
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

8364:ehhadh
gene id: 8364:ehhadh
uniprot id: L7N381
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

8364:onecut3
gene id: 8364:onecut3
uniprot id: A0A6I8SWT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8364:taf5
gene id: 8364:taf5
uniprot id: B4F725
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

8364:laptm4b
gene id: 8364:laptm4b
uniprot id: A0A6I8S9L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAPTM4/LAPTM5 transporter family.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: multivesicular body lumen
messages: multivesicular body membrane

8364:cyp2u1
gene id: 8364:cyp2u1
uniprot id: A8KBF5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:ttyh3
gene id: 8364:ttyh3
uniprot id: A0A8J0SY41
uniprot id: B1H141
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

8364:adamts8
gene id: 8364:adamts8
uniprot id: A0A8J0QSE7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:LOC100486462
gene id: 8364:LOC100486462
uniprot id: A0A8J0T3Q8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

8364:shbg
gene id: 8364:shbg
uniprot id: A0A803JL43
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:whamm
gene id: 8364:whamm
uniprot id: A0A803JIU4
names: Subcellular Location Annotation
messages: Membrane

8364:slc25a13
gene id: 8364:slc25a13
uniprot id: A0A8J1JMC9
uniprot id: B0JZG3
uniprot id: F7ATJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

8364:LOC116412424
gene id: 8364:LOC116412424
uniprot id: F6SHL8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:epha4
gene id: 8364:epha4
uniprot id: A0A8J0SWZ8
uniprot id: A0A8J0T0R8
uniprot id: A0A8J0T400
uniprot id: B4F704
uniprot id: F6QKP3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

8364:marcks
gene id: 8364:marcks
uniprot id: Q28ES5
uniprot id: Q6DIZ1
names: Similarity
messages: Belongs to the MARCKS family.

8364:LOC116407737
gene id: 8364:LOC116407737
uniprot id: A0A6I8SFV2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:tgm3l.2
gene id: 8364:tgm3l.2
uniprot id: F6YIE8
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

8364:tob1
gene id: 8364:tob1
uniprot id: Q28I92
names: Similarity
messages: Belongs to the BTG family.

8364:tnfaip2
gene id: 8364:tnfaip2
uniprot id: A0A6I8PYH2
names: Similarity
messages: Belongs to the SEC6 family.

8364:gla
gene id: 8364:gla
uniprot id: F6VA94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

8364:ing3
gene id: 8364:ing3
uniprot id: A0A8J1J761
uniprot id: A0A8J1J762
uniprot id: Q66KD5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).
messages: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

8364:hdc
gene id: 8364:hdc
uniprot id: A0A6I8Q2V4
uniprot id: A0A6I8RBZ8
uniprot id: F7BRU8
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

8364:htr6
gene id: 8364:htr6
uniprot id: A0A7D9NMD0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC100487890
gene id: 8364:LOC100487890
uniprot id: A0A6I8PZ96
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:epn3
gene id: 8364:epn3
uniprot id: Q6DJC6
names: Similarity
messages: Belongs to the epsin family.

8364:csrnp1
gene id: 8364:csrnp1
uniprot id: Q0P4X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

8364:LOC101730267
gene id: 8364:LOC101730267
uniprot id: A0A8J0R021
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:spsb4
gene id: 8364:spsb4
uniprot id: A0A6I8RXC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

8364:ift43
gene id: 8364:ift43
uniprot id: A0A8J0SKZ1
uniprot id: A0A8J0ST44
uniprot id: Q28CW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.
messages: Belongs to the IFT43 family.
messages: Component of the IFT complex A (IFT-A) complex.
messages: cilium
messages: cytoskeleton

8364:LOC105946957
gene id: 8364:LOC105946957
uniprot id: A0A8J1J8F4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:vps33b
gene id: 8364:vps33b
uniprot id: F6SGV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8364:chchd4
gene id: 8364:chchd4
uniprot id: Q6PBC3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.
messages: Mitochondrion intermembrane space
messages: Monomer. Can form homooligomers.
messages: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.

8364:selenoo
gene id: 8364:selenoo
uniprot id: A0A8J0QEA7
uniprot id: B4F6T8
names: Similarity
messages: Belongs to the SELO family.

8364:LOC116412293
gene id: 8364:LOC116412293
uniprot id: A0A8J1JW58
names: Subcellular Location Annotation
messages: Membrane

8364:st6galnac5
gene id: 8364:st6galnac5
uniprot id: A0A803KJ10
uniprot id: F7DC83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:LOC116412169
gene id: 8364:LOC116412169
uniprot id: A0A8J1JUV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dock5
gene id: 8364:dock5
uniprot id: A0A6I8QES5
uniprot id: A0A8J0QJ89
names: Similarity
messages: Belongs to the DOCK family.

8364:flna
gene id: 8364:flna
uniprot id: A0A6I8QK80
uniprot id: A0A6I8QUV6
uniprot id: A0A6I8S7R2
uniprot id: A0A8J0SLA0
uniprot id: A0A8J0T665
names: Similarity
messages: Belongs to the filamin family.

8364:pln
gene id: 8364:pln
uniprot id: A0A803K1S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

8364:mid1ip1
gene id: 8364:mid1ip1
uniprot id: Q6P8B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

8364:LOC100488698
gene id: 8364:LOC100488698
uniprot id: A0A8J0R2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:bcl9
gene id: 8364:bcl9
uniprot id: A0A6I8T1T1
uniprot id: F6QD69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

8364:LOC100496978
gene id: 8364:LOC100496978
uniprot id: A0A803JXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116407579
gene id: 8364:LOC116407579
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:kmt2d
gene id: 8364:kmt2d
uniprot id: A0A8J0SYQ0
uniprot id: A0A8J1J563
uniprot id: A0A8J1J566
uniprot id: A0A8J1J569
uniprot id: A0A8J1J7M0
uniprot id: A0A8J1J8L3
names: Subcellular Location Annotation
messages: Nucleus

8364:sostdc1
gene id: 8364:sostdc1
uniprot id: A4QNH1
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:vrk1
gene id: 8364:vrk1
uniprot id: Q6P8D6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:fgf4
gene id: 8364:fgf4
uniprot id: B7U3X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

8364:tacr3
gene id: 8364:tacr3
uniprot id: A0A6I8T2S3
uniprot id: F6WV10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the beta/gamma-crystallin family.
messages: Cell membrane
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.
messages: Membrane
messages: Monomer.

8364:LOC100485203
gene id: 8364:LOC100485203
uniprot id: A0A803JWJ6
uniprot id: A0A8J1IMV1
uniprot id: A0A8J1IMV2
uniprot id: A0A8J1IMV4
uniprot id: A0A8J1IMV6
uniprot id: A0A8J1IMV9
uniprot id: A0A8J1IQ65
uniprot id: A0A8J1IQ70
uniprot id: A0A8J1IQW5
uniprot id: A0A8J1IQX0
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

8364:pggt1b
gene id: 8364:pggt1b
uniprot id: Q66IH6
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

8364:c19orf54
gene id: 8364:c19orf54
uniprot id: A0A8J0SUU3
uniprot id: B0BM95
names: Similarity
messages: Belongs to the UPF0692 family.

8364:rangrf
gene id: 8364:rangrf
uniprot id: A0A1B8Y4P8
uniprot id: A0A8J0QY61
uniprot id: A0A8J0T017
names: Similarity
messages: Belongs to the MOG1 family.

8364:gpr35
gene id: 8364:gpr35
uniprot id: A0A8J0QIS0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:ehf
gene id: 8364:ehf
uniprot id: F6PYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:tjp1
gene id: 8364:tjp1
uniprot id: A0A6I8PXD5
uniprot id: A0A8J1JAY3
uniprot id: A0A8J1JAY4
uniprot id: A0A8J1JAY5
uniprot id: A0A8J1JAY8
uniprot id: A0A8J1JAY9
uniprot id: A0A8J1JDE4
uniprot id: A0A8J1JDE9
uniprot id: A0A8J1JEF9
uniprot id: A0A8J1JEG4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

8364:vcp
gene id: 8364:vcp
uniprot id: Q6GL04
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is inhibited or reduced by lowering pH from 9.0 to 7.0, and by addition of Ca(2+), EDTA, KNO(3) or by treatment with N-ethylmaleimide (NEM).
messages: Belongs to the AAA ATPase family.
messages: Endoplasmic reticulum
messages: Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry. Interacts with the FACT/DUF complex, which includes subunits ssrp1/duf87 and supt16h/duf140 (By similarity).
messages: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Plays a role in the regulation of stress granules (SGs) clearance process upon arsenite-induced response (By similarity). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (By similarity). Together with sprtn metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (By similarity). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Enhances cell cycle progression and inhibits apoptosis at low temperatures (By similarity). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (By similarity). Acts as a negative regulator of type I interferon production by promoting ubiquitination of rigi (By similarity). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (By similarity). May more particularly play a role in caveolins sorting in cells (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth f…
messages: Nucleus
messages: Phosphorylated.
messages: Stress granule
messages: cytosol

8364:onecut1
gene id: 8364:onecut1
uniprot id: A0A6I8SYT1
uniprot id: A4II00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8364:ppp5c
gene id: 8364:ppp5c
uniprot id: Q68EP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.
messages: Cytoplasm

8364:cycs
gene id: 8364:cycs
uniprot id: Q6PBF4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Mitochondrion intermembrane space

8364:hcfc2
gene id: 8364:hcfc2
uniprot id: A0A6I8RLL6
uniprot id: A0A8J0R2R1
names: Subcellular Location Annotation
messages: Nucleus

8364:aadacl3
gene id: 8364:aadacl3
uniprot id: F6Z8F0
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

8364:jun
gene id: 8364:jun
uniprot id: A0A803K0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

8364:gpc5
gene id: 8364:gpc5
uniprot id: A0A6I8PV93
uniprot id: A0A6I8Q0C9
uniprot id: F7AHQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: Golgi apparatus
messages: Membrane
messages: secretory vesicle membrane

8364:c11orf49
gene id: 8364:c11orf49
uniprot id: Q0VFE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

8364:LOC108644800
gene id: 8364:LOC108644800
uniprot id: A0A8J0SZ94
names: Subcellular Location Annotation
messages: Membrane

8364:kif4a
gene id: 8364:kif4a
uniprot id: A0A8J1IL75
uniprot id: Q6DIN5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:trmt11
gene id: 8364:trmt11
uniprot id: A0A8J0QMW9
uniprot id: A0A8J0T4B0
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

8364:cox17
gene id: 8364:cox17
uniprot id: Q0VFB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

8364:tmem50b
gene id: 8364:tmem50b
uniprot id: Q28G39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

8364:tmem38b
gene id: 8364:tmem38b
uniprot id: Q28FA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM38 family.
messages: Endoplasmic reticulum membrane
messages: Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

8364:LOC100486303
gene id: 8364:LOC100486303
uniprot id: A0A8J0QYT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100492198
gene id: 8364:LOC100492198
uniprot id: A0A8J0QU04
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hcrt
gene id: 8364:hcrt
uniprot id: A0A803J4X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Synapse
messages: Vesicle

8364:ppm1h
gene id: 8364:ppm1h
uniprot id: Q28DF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Cytoplasm
messages: Nucleus

8364:LOC116408597
gene id: 8364:LOC116408597
uniprot id: A0A8J1J603
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:ovos2
gene id: 8364:ovos2
uniprot id: F7DI46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:pold3
gene id: 8364:pold3
uniprot id: A0A8J0PI21
uniprot id: A0A8J1J1W6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100485327
gene id: 8364:LOC100485327
uniprot id: A0A8J1J0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

8364:gbe1
gene id: 8364:gbe1
uniprot id: F6ZJE3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

8364:usp19
gene id: 8364:usp19
uniprot id: F6X7M7
names: Similarity
messages: Belongs to the peptidase M10A family.

8364:trmt10c
gene id: 8364:trmt10c
uniprot id: A4IHS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: Component of mitochondrial ribonuclease P. Interacts with HSD17B10/MRPP2.
messages: Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, which cleaves tRNA molecules in their 5'-ends. Together with hsd17b10/mrpp2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; trmt10c/mrpp1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after elac2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, trmt10c/mrpp1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA.
messages: mitochondrion nucleoid

8364:mtmr8
gene id: 8364:mtmr8
uniprot id: A0A6I8QYJ5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:lix1
gene id: 8364:lix1
uniprot id: A0A8J0QNE6
uniprot id: F7D8Q8
names: Similarity
messages: Belongs to the LIX1 family.

8364:LOC116410254
gene id: 8364:LOC116410254
uniprot id: A0A803K900
uniprot id: A0A8J1JEM1
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gins3
gene id: 8364:gins3
uniprot id: B0JZ19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

8364:LOC733556
gene id: 8364:LOC733556
uniprot id: A0A803JZF4
uniprot id: A0A8J1JIW0
uniprot id: F7AIP4
uniprot id: Q28GK5
names: Similarity
messages: Belongs to the MS4A family.

8364:zc2hc1c
gene id: 8364:zc2hc1c
uniprot id: A0A8J1IS40
names: Similarity
messages: Belongs to the ZC2HC1 family.

8364:nlgn1
gene id: 8364:nlgn1
uniprot id: A0A6I8QK87
uniprot id: A0A6I8RTS2
uniprot id: D2X2K4
uniprot id: F6WUA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8364:tram1
gene id: 8364:tram1
uniprot id: Q6NVP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

8364:LOC100492027
gene id: 8364:LOC100492027
uniprot id: A0A8J0QSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rhbdl1
gene id: 8364:rhbdl1
uniprot id: A0A803K1K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

8364:crygdl.39
gene id: 8364:crygdl.39
uniprot id: A0A8J0QTJ1
uniprot id: A0A8J0QYR9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:tgs1
gene id: 8364:tgs1
uniprot id: A0A8J0SQI8
uniprot id: A0A8J0SUX4
uniprot id: F6YTE0
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

8364:agtr2
gene id: 8364:agtr2
uniprot id: F6Z3M6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

8364:slitrk4
gene id: 8364:slitrk4
uniprot id: F7BNQ6
names: Similarity
messages: Belongs to the SLITRK family.

8364:cox4i2
gene id: 8364:cox4i2
uniprot id: Q28FR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

8364:MGC79725
gene id: 8364:MGC79725
uniprot id: Q6DFP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8364:aldoa
gene id: 8364:aldoa
uniprot id: Q6GL64
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

8364:LOC116406747
gene id: 8364:LOC116406747
uniprot id: A0A6I8SIP7
names: Similarity
messages: Belongs to the FBPase class 1 family.

8364:dtd1
gene id: 8364:dtd1
uniprot id: B1H1C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

8364:LOC100487746
gene id: 8364:LOC100487746
uniprot id: A0A803KBZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:tmem242
gene id: 8364:tmem242
uniprot id: B7ZTD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

8364:foxf2
gene id: 8364:foxf2
uniprot id: A4IIG1
names: Subcellular Location Annotation
messages: Nucleus

8364:pcmt1
gene id: 8364:pcmt1
uniprot id: A0A8J0SNY7
uniprot id: A0A8J1JIA7
uniprot id: A0A8J1JIA8
uniprot id: Q5BKH1
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

8364:LOC100496633
gene id: 8364:LOC100496633
uniprot id: A0A8J0QPG4
uniprot id: A0A8J0QTL3
uniprot id: A0A8J0QUM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

8364:ndufc2
gene id: 8364:ndufc2
uniprot id: A0A1B8Y3G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

8364:chek1
gene id: 8364:chek1
uniprot id: A0A6I8Q227
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

8364:LOC100486268
gene id: 8364:LOC100486268
uniprot id: F6PWM4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:LOC100494266
gene id: 8364:LOC100494266
uniprot id: A0A6I8R1L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

8364:alg2
gene id: 8364:alg2
uniprot id: A0A803KL01
uniprot id: F6Y018
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

8364:idua
gene id: 8364:idua
uniprot id: A0A6I8SI02
uniprot id: A0A8J0T610
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

8364:slc12a3
gene id: 8364:slc12a3
uniprot id: L7N3R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

8364:khdrbs2
gene id: 8364:khdrbs2
uniprot id: A0A8J1JIE1
uniprot id: Q0VFL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDRBS family.
messages: Nucleus
messages: RNA-binding protein that plays a role in the regulation of alternative splicing.

8364:slc39a7
gene id: 8364:slc39a7
uniprot id: A0A7D9NJU8
names: Subcellular Location Annotation
messages: Membrane

8364:syndig1
gene id: 8364:syndig1
uniprot id: A4IGW9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:cd36l
gene id: 8364:cd36l
uniprot id: A0A6I8S279
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

8364:tmco4
gene id: 8364:tmco4
uniprot id: A0A803JWI1
uniprot id: A0A8J1JWU3
names: Similarity
messages: Belongs to the TMCO4 family.

8364:jrk
gene id: 8364:jrk
uniprot id: A0A6I8PRF9
uniprot id: A0A8J0R7Z8
names: Subcellular Location Annotation
messages: Nucleus

8364:cpa3
gene id: 8364:cpa3
uniprot id: A0A6I8SCX3
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:pthlh
gene id: 8364:pthlh
uniprot id: F6WB14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

8364:LOC100487011
gene id: 8364:LOC100487011
uniprot id: A0A6I8PVW8
names: Similarity
messages: Belongs to the NXPE family.

8364:h2bc12
gene id: 8364:h2bc12
uniprot id: Q6AZK7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:trappc6a
gene id: 8364:trappc6a
uniprot id: Q6NVQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

8364:tspan1
gene id: 8364:tspan1
uniprot id: Q28F80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:LOC100489375
gene id: 8364:LOC100489375
uniprot id: F6ZCC3
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

8364:LOC594991
gene id: 8364:LOC594991
uniprot id: F7ADL6
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:LOC100490896
gene id: 8364:LOC100490896
uniprot id: A0A8J1IQ84
uniprot id: A0A8J1ISN1
names: Similarity
messages: Belongs to the MHC class I family.

8364:LOC116409556
gene id: 8364:LOC116409556
uniprot id: A0A8J1J899
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116407755
gene id: 8364:LOC116407755
uniprot id: A0A8J1IVH6
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nodal1
gene id: 8364:nodal1
uniprot id: Q28GB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also dorsalizes ventral marginal zone (VMZ) tissues during gastrulation. Acts in a downstream signaling cascade via cripto and cer1 to mediate cardiogenesis in embryonic mesoderm. Directs the orientation of the left-right axis by driving the left-specific gene cascade in the left lateral plate mesoderm (By similarity).
messages: Homodimer; disulfide-linked. Interacts with, and is inhibited by cer1 and gdf10/bmp3b.
messages: Secreted

8364:kcna5
gene id: 8364:kcna5
uniprot id: A0A6I8RVY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

8364:rnf13
gene id: 8364:rnf13
uniprot id: Q66JJ1
names: Subcellular Location Annotation
messages: Membrane

8364:gapvd1
gene id: 8364:gapvd1
uniprot id: A0A8J0QU88
uniprot id: A0A8J0R3Q5
uniprot id: A0A8J0R658
uniprot id: A0A8J0R6L2
uniprot id: A0A8J0SLR2
uniprot id: A0A8J0STW5
uniprot id: A0A8J0SWC6
uniprot id: A0A8J1IPG2
uniprot id: A0A8J1IPG6
uniprot id: A0A8J1IPG8
uniprot id: A0A8J1IRW6
uniprot id: A0A8J1IRX1
uniprot id: A0A8J1ISL2
uniprot id: A0A8J1ISL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

8364:LOC100489247
gene id: 8364:LOC100489247
uniprot id: A0A6I8S962
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:chrna5
gene id: 8364:chrna5
uniprot id: A0A6I8SMR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:t2r52
gene id: 8364:t2r52
uniprot id: Q2AB35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:map1lc3b
gene id: 8364:map1lc3b
uniprot id: Q6P2W9
names: Similarity
messages: Belongs to the ATG8 family.

8364:kctd10
gene id: 8364:kctd10
uniprot id: A0A8J0PHX9
uniprot id: F6U3U6
uniprot id: Q28HW7
names: Similarity
messages: Belongs to the BACURD family.

8364:fgfr4
gene id: 8364:fgfr4
uniprot id: F6VYS9
uniprot id: Q28GC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:mmp25
gene id: 8364:mmp25
uniprot id: F7BXU6
names: Similarity
messages: Belongs to the peptidase M10A family.

8364:csnk1g3
gene id: 8364:csnk1g3
uniprot id: A0A6I8PY01
uniprot id: A0A6I8R6G6
uniprot id: A0A8J0SEB2
uniprot id: B6ID06
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

8364:rsph6a
gene id: 8364:rsph6a
uniprot id: A1L0Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flagellar radial spoke RSP4/6 family.
messages: flagellum
messages: flagellum axoneme

8364:crnkl1
gene id: 8364:crnkl1
uniprot id: F7C1G4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:rida
gene id: 8364:rida
uniprot id: Q28GJ3
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

8364:LOC116412139
gene id: 8364:LOC116412139
uniprot id: A0A8J1JYM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gar1
gene id: 8364:gar1
uniprot id: Q5RJV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the telomerase holoenzyme complex.
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

8364:ppdpf
gene id: 8364:ppdpf
uniprot id: A4IGU9
names: Function
names: Similarity
messages: Belongs to the PPDPF family.
messages: Probable regulator of exocrine pancreas development.

8364:rimkla
gene id: 8364:rimkla
uniprot id: B1H339
names: Similarity
messages: Belongs to the RimK family.

8364:slc9a7
gene id: 8364:slc9a7
uniprot id: B2GUM7
uniprot id: F7BFD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

8364:mmp9.1
gene id: 8364:mmp9.1
uniprot id: Q6DF16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

8364:LOC100494227
gene id: 8364:LOC100494227
uniprot id: L7N2L9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:trhd
gene id: 8364:trhd
uniprot id: A0A803J286
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8364:LOC100489587
gene id: 8364:LOC100489587
uniprot id: A0A6I8RLQ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:abracl
gene id: 8364:abracl
uniprot id: A0A6I8S2R4
uniprot id: A4IHJ3
names: Similarity
messages: Belongs to the costars family.

8364:slc45a1
gene id: 8364:slc45a1
uniprot id: A4II12
names: Subcellular Location Annotation
messages: Membrane

8364:phyhdla.3
gene id: 8364:phyhdla.3
uniprot id: F6WCC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:smc2
gene id: 8364:smc2
uniprot id: A0A6I8RY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

8364:rnaseh2b
gene id: 8364:rnaseh2b
uniprot id: A0A6I8RBL4
uniprot id: A0A8J0SEI9
uniprot id: A0A8J1J496
uniprot id: A0A8J1J587
uniprot id: Q28GD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit rnaseh2a and the non-catalytic subunits rnaseh2b and rnaseh2c.

8364:LOC100490987
gene id: 8364:LOC100490987
uniprot id: A0A803JQU4
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:gstp1
gene id: 8364:gstp1
uniprot id: Q28IG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

8364:chd2
gene id: 8364:chd2
uniprot id: A0A6I8Q0Q2
uniprot id: A0A8J0T1Z3
names: Subcellular Location Annotation
messages: Nucleus

8364:slc16a2
gene id: 8364:slc16a2
uniprot id: A0A8J1IQK8
names: Subcellular Location Annotation
messages: Membrane

8364:tspan6
gene id: 8364:tspan6
uniprot id: F6QNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:fam126b
gene id: 8364:fam126b
uniprot id: A0A6I8PWA7
uniprot id: A0A6I8R787
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

8364:dnah1
gene id: 8364:dnah1
uniprot id: A0A6I8PVM9
uniprot id: A0A8J1JK30
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:man2a1
gene id: 8364:man2a1
uniprot id: A9UM36
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

8364:tmem269
gene id: 8364:tmem269
uniprot id: A0A803JUX0
uniprot id: B0BLZ6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

8364:clns1a
gene id: 8364:clns1a
uniprot id: A0A8J1J1P8
uniprot id: Q28H03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

8364:xgb
gene id: 8364:xgb
uniprot id: Q5QSB2
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:snap91
gene id: 8364:snap91
uniprot id: A0A6I8PYS9
uniprot id: A0A6I8SCD5
uniprot id: A0A8J0SDR6
uniprot id: A0A8J0SDR8
uniprot id: A0A8J0SKS0
uniprot id: A0A8J0SKS5
uniprot id: A0A8J0SKT2
uniprot id: A0A8J0SM65
uniprot id: A0A8J0SNF4
uniprot id: A0A8J0SNI1
uniprot id: A0A8J0SNI6
uniprot id: A0A8J1JHQ8
uniprot id: A0A8J1JLB5
uniprot id: B3DLI8
uniprot id: F6WGC4
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

8364:msr1
gene id: 8364:msr1
uniprot id: A0A803KE28
names: Subcellular Location Annotation
messages: Membrane

8364:slc25a44
gene id: 8364:slc25a44
uniprot id: Q66JC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:rabl3
gene id: 8364:rabl3
uniprot id: A4IHM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Homodimer.
messages: Required for KRAS signaling regulation and modulation of cell proliferation (By similarity). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (By similarity). Required for lymphocyte development and function (By similarity). Not required for myeloid cell development (By similarity).

8364:LOC116406662
gene id: 8364:LOC116406662
uniprot id: A0A8J1IN98
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:pear1
gene id: 8364:pear1
uniprot id: K9J8B0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:agrp
gene id: 8364:agrp
uniprot id: A0A8J1JFG4
uniprot id: J3A6E8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:rsbn1l
gene id: 8364:rsbn1l
uniprot id: Q28DE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins.
messages: Nucleus

8364:th2
gene id: 8364:th2
uniprot id: A0A803J5C5
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

8364:LOC105947944
gene id: 8364:LOC105947944
uniprot id: A0A8J0T5I9
names: Similarity
messages: Belongs to the Izumo family.

8364:ndfip1
gene id: 8364:ndfip1
uniprot id: A0A6I8RRE8
uniprot id: A0A803JS05
uniprot id: Q4V786
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May play a role in Golgi structure maintenance.
messages: Membrane

8364:sdf4
gene id: 8364:sdf4
uniprot id: Q5BKL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen
messages: May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.

8364:aspg
gene id: 8364:aspg
uniprot id: F7B322
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

8364:LOC100489305
gene id: 8364:LOC100489305
uniprot id: A0A6I8STL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

8364:LOC100493140
gene id: 8364:LOC100493140
uniprot id: F7CDE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8364:mmp2
gene id: 8364:mmp2
uniprot id: Q5FVW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

8364:LOC100498016
gene id: 8364:LOC100498016
uniprot id: A0A8J1IQV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8364:rab27a
gene id: 8364:rab27a
uniprot id: A0A6I8PW45
uniprot id: Q66KA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

8364:LOC100488761
gene id: 8364:LOC100488761
uniprot id: A0A8J0SWQ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:g6pc3.1
gene id: 8364:g6pc3.1
uniprot id: A0A8J0SZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

8364:ap1g1
gene id: 8364:ap1g1
uniprot id: A0A6I8QYC5
uniprot id: A0A6I8SWT5
uniprot id: A0A8J0QYE4
uniprot id: A0A8J0STD6
uniprot id: F6RS91
names: Similarity
messages: Belongs to the UFL1 family.
messages: Belongs to the adaptor complexes large subunit family.

8364:LOC101734514
gene id: 8364:LOC101734514
uniprot id: A0A8J1K0Z9
names: Similarity
messages: Belongs to the leprecan family.

8364:LOC116411534
gene id: 8364:LOC116411534
uniprot id: A0A803JS36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

8364:stim2
gene id: 8364:stim2
uniprot id: A0A803K290
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:tnfrsf11b
gene id: 8364:tnfrsf11b
uniprot id: A0A7D9NJN5
uniprot id: A0A803K7X4
uniprot id: L7N3J0
names: Caution
names: Similarity
messages: Belongs to the AP-2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:taf1d
gene id: 8364:taf1d
uniprot id: A0A8J0QLQ6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

8364:camsap1
gene id: 8364:camsap1
uniprot id: A0A6I8QTQ8
uniprot id: F6TMK5
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

8364:acta1
gene id: 8364:acta1
uniprot id: F6UH63
names: Similarity
messages: Belongs to the actin family.

8364:oip5
gene id: 8364:oip5
uniprot id: A0A6I8SI93
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

8364:vamp1
gene id: 8364:vamp1
uniprot id: A0A6I8Q031
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane

8364:dcaf1
gene id: 8364:dcaf1
uniprot id: A0A6I8SPT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

8364:LOC108648794
gene id: 8364:LOC108648794
uniprot id: A0A8J0T3R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:usp45
gene id: 8364:usp45
uniprot id: A0A6I8PLY4
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:cenpu
gene id: 8364:cenpu
uniprot id: A0A6I8PZ31
uniprot id: A0A803J8C5
uniprot id: Q0P4J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

8364:parp4.1
gene id: 8364:parp4.1
uniprot id: A0A8J1J615
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

8364:znf706l
gene id: 8364:znf706l
uniprot id: Q28JA7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:neil2
gene id: 8364:neil2
uniprot id: A9ULI4
names: Similarity
messages: Belongs to the FPG family.

8364:cacna2d1
gene id: 8364:cacna2d1
uniprot id: A1L1E0
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

8364:pacsin1
gene id: 8364:pacsin1
uniprot id: A0A6I8QHL6
uniprot id: A0A8J1J4C6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

8364:ltv1
gene id: 8364:ltv1
uniprot id: F7AKE2
names: Similarity
messages: Belongs to the LTV1 family.

8364:tbl1x
gene id: 8364:tbl1x
uniprot id: B1H2M5
names: Similarity
messages: Belongs to the WD repeat EBI family.

8364:rpl36
gene id: 8364:rpl36
uniprot id: Q6DER2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL36 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm
messages: cytosol

8364:pparg
gene id: 8364:pparg
uniprot id: A0A8J1JJG3
uniprot id: A0A8J1JKJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

8364:psat1
gene id: 8364:psat1
uniprot id: Q28I26
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

8364:h1-1
gene id: 8364:h1-1
uniprot id: A0A8J0PIA9
uniprot id: Q07GA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:cnga2
gene id: 8364:cnga2
uniprot id: A0A6I8PNK9
uniprot id: A0A8J0R677
names: Subcellular Location Annotation
messages: Membrane

8364:fam189b
gene id: 8364:fam189b
uniprot id: A0A8J1INI8
uniprot id: A0A8J1IQY1
names: Similarity
messages: Belongs to the ENTREP family.

8364:homer2
gene id: 8364:homer2
uniprot id: Q28EU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

8364:fxyd1
gene id: 8364:fxyd1
uniprot id: A0A803JHU9
uniprot id: A0A8J1JV38
uniprot id: Q5M8E9
names: Similarity
messages: Belongs to the FXYD family.

8364:LOC100492274
gene id: 8364:LOC100492274
uniprot id: A0A6I8S211
uniprot id: A0A8J1JR17
names: Subcellular Location Annotation
messages: Membrane

8364:gbx2.2
gene id: 8364:gbx2.2
uniprot id: Q5I079
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101730999
gene id: 8364:LOC101730999
uniprot id: A0A6I8SQD1
names: Subcellular Location Annotation
messages: Membrane

8364:cldn14
gene id: 8364:cldn14
uniprot id: F6QP38
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:hk1
gene id: 8364:hk1
uniprot id: A0A6I8SCZ6
uniprot id: A4II49
names: Similarity
messages: Belongs to the hexokinase family.

8364:tcp11l1
gene id: 8364:tcp11l1
uniprot id: A0A6I8SF60
uniprot id: A8KBD8
names: Similarity
messages: Belongs to the TCP11 family.

8364:atp5f1c
gene id: 8364:atp5f1c
uniprot id: A0A6I8PXM9
uniprot id: A0A8J0PHQ6
uniprot id: F6XES7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

8364:tacc1
gene id: 8364:tacc1
uniprot id: A0A8J0QI95
uniprot id: A0A8J0QX83
uniprot id: A0A8J0S9Y7
uniprot id: A0A8J0SG65
uniprot id: A0A8J0SJ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

8364:prim1
gene id: 8364:prim1
uniprot id: Q6NVT9
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

8364:scyl1
gene id: 8364:scyl1
uniprot id: Q28FH2
names: Domain
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.
messages: The protein kinase domain is predicted to be catalytically inactive.

8364:mrpl37
gene id: 8364:mrpl37
uniprot id: F6R7P1
names: Subcellular Location Annotation
messages: Mitochondrion

8364:krt78.2
gene id: 8364:krt78.2
uniprot id: A0A8J0QRD3
names: Similarity
messages: Belongs to the intermediate filament family.

8364:polr2l.1
gene id: 8364:polr2l.1
uniprot id: Q28GI6
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

8364:barx1
gene id: 8364:barx1
uniprot id: A0A1B8XZX2
uniprot id: A0A6I8T0G8
names: Subcellular Location Annotation
messages: Nucleus

8364:znf574
gene id: 8364:znf574
uniprot id: Q6GL52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

8364:ndst1
gene id: 8364:ndst1
uniprot id: F6Z0F4
uniprot id: Q5U4X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.
messages: trans-Golgi network membrane

8364:hook1
gene id: 8364:hook1
uniprot id: A0A6I8RNQ2
uniprot id: A4IIU6
uniprot id: F7CDG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

8364:ncan
gene id: 8364:ncan
uniprot id: A0A6I8Q003
uniprot id: F6YUS7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116410450
gene id: 8364:LOC116410450
uniprot id: A0A6I8RWM2
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:aqp2
gene id: 8364:aqp2
uniprot id: A0A803KK56
uniprot id: F6RW76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:med20
gene id: 8364:med20
uniprot id: A0A7D9NL53
uniprot id: A0A8J0QJM5
uniprot id: A0A8J1J4B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:ttc27
gene id: 8364:ttc27
uniprot id: A0A6I8QYT2
uniprot id: A0A6I8RZ65
names: Similarity
messages: Belongs to the TTC27 family.

8364:LOC101732341
gene id: 8364:LOC101732341
uniprot id: A0A6I8PZN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

8364:ctsd
gene id: 8364:ctsd
uniprot id: Q6P7Z8
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:LOC100037901
gene id: 8364:LOC100037901
uniprot id: A0A5G3HUQ0
names: Similarity
messages: Belongs to the globin family.

8364:edem3
gene id: 8364:edem3
uniprot id: A0A8J0QLN7
uniprot id: A0A8J0T0K1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8364:LOC108647711
gene id: 8364:LOC108647711
uniprot id: A0A8J1JMB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:kcnk7
gene id: 8364:kcnk7
uniprot id: B0BLT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

8364:scarf2
gene id: 8364:scarf2
uniprot id: A0A803JVX0
uniprot id: A0A8J1IT50
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ablim1
gene id: 8364:ablim1
uniprot id: A0A6I8R657
uniprot id: A0A6I8RNE1
uniprot id: A0A8J1JW75
uniprot id: A0A8J1JW78
uniprot id: A0A8J1JW80
uniprot id: A0A8J1JW81
uniprot id: A0A8J1JW83
uniprot id: A0A8J1JW85
uniprot id: A0A8J1JW86
uniprot id: A0A8J1JW88
uniprot id: A0A8J1JW90
uniprot id: A0A8J1JW93
uniprot id: A0A8J1JW95
uniprot id: A0A8J1JW96
uniprot id: A0A8J1JW97
uniprot id: A0A8J1JW99
uniprot id: A0A8J1JWA1
uniprot id: A0A8J1JWA4
uniprot id: A0A8J1JWA5
uniprot id: A0A8J1JWB0
uniprot id: A0A8J1JWB1
uniprot id: A0A8J1JYP7
uniprot id: A0A8J1JYR3
uniprot id: A0A8J1JYS4
uniprot id: A0A8J1JYS9
uniprot id: A0A8J1K094
uniprot id: A0A8J1K099
uniprot id: A0A8J1K0A4
uniprot id: A0A8J1K0A9
uniprot id: A0A8J1K0C0
uniprot id: A0A8J1K0C5
names: Subcellular Location Annotation
messages: Cytoplasm

8364:stag3
gene id: 8364:stag3
uniprot id: A0A6I8RR30
uniprot id: A0A8J1J6L4
uniprot id: B1H2R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

8364:LOC105945395
gene id: 8364:LOC105945395
uniprot id: A0A8J0SCB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:pnlip
gene id: 8364:pnlip
uniprot id: A0A8J1JS00
uniprot id: A0A8J1JS08
uniprot id: B1H305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8364:cdca9
gene id: 8364:cdca9
uniprot id: Q0V9F7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the borealin family.
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B Interacts with incenp (via N-terminus).
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Contributes to CPC function by facilitating loading of the CPC onto chromosomes (By similarity).
messages: Nucleus
messages: centromere
messages: spindle

8364:opn4
gene id: 8364:opn4
uniprot id: A0A6I8Q0P6
uniprot id: A0A6I8S6Q1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:mknk1
gene id: 8364:mknk1
uniprot id: A0A8J1JGV2
uniprot id: Q28HV8
uniprot id: Q66JF3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).

8364:LOC116406534
gene id: 8364:LOC116406534
uniprot id: A0A803JXW0
names: Similarity
messages: Belongs to the cyclin family.

8364:ndfip2
gene id: 8364:ndfip2
uniprot id: A0A6I8QQ41
uniprot id: A0A8J0PIS5
names: Subcellular Location Annotation
messages: Membrane

8364:tgfb2
gene id: 8364:tgfb2
uniprot id: A0A6I8R415
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

8364:rsph3
gene id: 8364:rsph3
uniprot id: F7AKI7
names: Similarity
messages: Belongs to the flagellar radial spoke RSP3 family.

8364:LOC101734099
gene id: 8364:LOC101734099
uniprot id: A0A8J1JBT5
uniprot id: A0A8J1JBT7
uniprot id: A0A8J1JFA2
names: Subcellular Location Annotation
messages: Secreted

8364:naga
gene id: 8364:naga
uniprot id: A0A6R5A7S2
uniprot id: Q0P4I8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

8364:LOC100488897
gene id: 8364:LOC100488897
uniprot id: A0A8J1JTM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:LOC116408629
gene id: 8364:LOC116408629
uniprot id: A0A8J1J2Q7
names: Subcellular Location Annotation
messages: Membrane

8364:hmgn3
gene id: 8364:hmgn3
uniprot id: A0A6I8PJ20
uniprot id: A0A6I8PN05
uniprot id: A0A8J0SNT8
uniprot id: F7A3R4
uniprot id: Q28GS1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8364:crygbl.2
gene id: 8364:crygbl.2
uniprot id: A0A803J3L5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:dhdh
gene id: 8364:dhdh
uniprot id: B1WBL2
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

8364:slc25a38
gene id: 8364:slc25a38
uniprot id: Q6DJ08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: May play a role as pro-apoptotic protein that induces caspase-dependent apoptosis.
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane

8364:LOC116407540
gene id: 8364:LOC116407540
uniprot id: A0A6I8PJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:tspan14
gene id: 8364:tspan14
uniprot id: F6YL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:LOC100486323
gene id: 8364:LOC100486323
uniprot id: A0A6I8QAK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Membrane

8364:mrps23
gene id: 8364:mrps23
uniprot id: F6W7L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

8364:atp6v0e1
gene id: 8364:atp6v0e1
uniprot id: B4F6J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8364:LOC116411016
gene id: 8364:LOC116411016
uniprot id: A0A8J1JPU8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:kcnk12
gene id: 8364:kcnk12
uniprot id: A0A8J1JLL9
uniprot id: F6WH56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8364:ndufa10
gene id: 8364:ndufa10
uniprot id: Q5M8K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

8364:trpm8b
gene id: 8364:trpm8b
uniprot id: A0A6I8PW05
uniprot id: A0A6I8QL26
uniprot id: A0A8J1IS36
uniprot id: C5IJY9
uniprot id: F6TBS4
names: Subcellular Location Annotation
messages: Membrane

8364:ephb3
gene id: 8364:ephb3
uniprot id: A0A6I8RKK6
uniprot id: F6W1P4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.
messages: Membrane

8364:LOC101735190
gene id: 8364:LOC101735190
uniprot id: A0A8J1JLW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8364:babam1
gene id: 8364:babam1
uniprot id: Q5M8J0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM1 family.
messages: Component of the ARISC complex, at least composed of uimc1/rap80, abraxas1, brcc3/brcc36, BABAM2 and babam1/nba1. Component of the BRCA1-A complex, at least composed of brca1, bard1, uimc1/rap80, abraxas1, brcc3/brcc36, BABAM2 and babam1/nba1. In the BRCA1-A complex, interacts directly with abraxas1 and BABAM2. Component of the BRISC complex, at least composed of abraxas2, brcc3/brcc36, babam2 and babam1/nba1.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by brcc3/brcc36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.
messages: Cytoplasm
messages: Nucleus
messages: The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.

8364:vipas39
gene id: 8364:vipas39
uniprot id: B1WAS8
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Vesicle

8364:LOC108648247
gene id: 8364:LOC108648247
uniprot id: A0A8J0T5A5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:fam83f
gene id: 8364:fam83f
uniprot id: A0A6I8QNA4
names: Similarity
messages: Belongs to the FAM83 family.

8364:LOC101730371
gene id: 8364:LOC101730371
uniprot id: A0A6I8SFV2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:tmprss4
gene id: 8364:tmprss4
uniprot id: A0A8J0STM8
uniprot id: A0A8J1JVD8
uniprot id: Q28DA4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:hint2
gene id: 8364:hint2
uniprot id: A0A803JAB9
names: Similarity
messages: Belongs to the HINT family.

8364:fmnl2
gene id: 8364:fmnl2
uniprot id: A0A6I8QPV0
uniprot id: A0A6I8QVV0
uniprot id: A0A6I8S2E4
uniprot id: A0A8J0QPG2
uniprot id: A0A8J0SVY3
uniprot id: A0A8J0SXS7
uniprot id: A0A8J0SYF1
uniprot id: F6TFR9
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Belongs to the formin homology family.

8364:wdr45b
gene id: 8364:wdr45b
uniprot id: Q640T2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2.
messages: Lysosome
messages: Preautophagosomal structure
messages: The L/FRRG motif is required for recruitment to PtdIns3P.

8364:trmt112
gene id: 8364:trmt112
uniprot id: F6WPP0
uniprot id: Q28IT5
names: Similarity
messages: Belongs to the TRM112 family.

8364:hmces
gene id: 8364:hmces
uniprot id: Q6P7N4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SOS response-associated peptidase family.
messages: Chromosome
messages: Glu-129 is involved in sensing abasic sites in single-stranded DNA (ssDNA). His-203 stabilizes the abasic sites by forming a hydrogen bond with the O4' hydroxyl group.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).

8364:itgav
gene id: 8364:itgav
uniprot id: A0A6I8QC93
uniprot id: B1WAV5
uniprot id: F7A493
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:LOC116412144
gene id: 8364:LOC116412144
uniprot id: A0A8J1JX74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ddit4l
gene id: 8364:ddit4l
uniprot id: A0A6I8RXS0
names: Similarity
messages: Belongs to the DDIT4 family.

8364:emp3
gene id: 8364:emp3
uniprot id: Q5XGD1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:slc39a11
gene id: 8364:slc39a11
uniprot id: A0A8J0SQX6
uniprot id: A0A8J0SXA6
uniprot id: A0A8J1IYY2
uniprot id: Q28J44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Cytoplasm
messages: Functions as a cellular zinc transporter.
messages: Golgi apparatus
messages: Membrane
messages: Nucleus

8364:frmd8
gene id: 8364:frmd8
uniprot id: Q0IJ35
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Promotes the cell surface stability of RHBDF1 and RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on RHBDF proteins, involved in ADAM17-mediated ligand shedding (By similarity). May negatively regulate Wnt signaling (By similarity).
messages: cytosol

8364:edn1
gene id: 8364:edn1
uniprot id: F7ADY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

8364:LOC100495408
gene id: 8364:LOC100495408
uniprot id: A0A8J1J818
uniprot id: A0A8J1J822
names: Similarity
messages: Belongs to the nucleoplasmin family.

8364:arhgef28
gene id: 8364:arhgef28
uniprot id: A0A6I8QLR5
uniprot id: A0A6I8SM83
uniprot id: A0A8J0QZI9
uniprot id: A0A8J0S9R7
uniprot id: A0A8J1IVG9
names: Subcellular Location Annotation
messages: Cytoplasm

8364:anxa5
gene id: 8364:anxa5
uniprot id: Q640T3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

8364:h2az2
gene id: 8364:h2az2
uniprot id: Q5BJ65
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated on Lys-5, Lys-8 and Lys-12 when associated with the 5'-end of active genes.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ2 forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).

8364:msrb3
gene id: 8364:msrb3
uniprot id: A0A8J1JAM0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

8364:LOC116406730
gene id: 8364:LOC116406730
uniprot id: F7BGJ7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:pla2g15
gene id: 8364:pla2g15
uniprot id: A0A803J590
uniprot id: F6UY66
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

8364:plpp1
gene id: 8364:plpp1
uniprot id: B0BM26
uniprot id: Q5XGH7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

8364:hacd4
gene id: 8364:hacd4
uniprot id: A0A6I8RKB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:map7d3
gene id: 8364:map7d3
uniprot id: A0A803J8L3
uniprot id: A0A8J0QI48
uniprot id: A0A8J0R3Y4
uniprot id: A0A8J0R5U7
uniprot id: A0A8J0R6T9
uniprot id: A0A8J0SM01
uniprot id: A0A8J0SX68
uniprot id: F6PUN7
names: Similarity
messages: Belongs to the MAP7 family.

8364:LOC116407635
gene id: 8364:LOC116407635
uniprot id: A0A8J1IUE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

8364:fam92a
gene id: 8364:fam92a
uniprot id: A0A8J0SQ86
uniprot id: A9UL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIBAR family.
messages: centriole

8364:dnaaf3
gene id: 8364:dnaaf3
uniprot id: I6L707
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

8364:cept1
gene id: 8364:cept1
uniprot id: A0A8J0SMS2
uniprot id: B1H2K0
uniprot id: Q28H54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane

8364:bco2l
gene id: 8364:bco2l
uniprot id: A0A6I8R1T0
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

8364:adcyap1r1
gene id: 8364:adcyap1r1
uniprot id: A0A1B8YA01
uniprot id: A0A803KGP5
uniprot id: A0A8J1JN68
uniprot id: Q0V9U7
names: Subcellular Location Annotation
messages: Membrane

8364:ndufa13
gene id: 8364:ndufa13
uniprot id: Q6PBF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

8364:nfatc1
gene id: 8364:nfatc1
uniprot id: A0A6I8PRL5
uniprot id: A0A6I8QJN6
uniprot id: A0A6I8SA77
uniprot id: A0A6I8SP12
uniprot id: A0A8J0SQ70
uniprot id: F6T5A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Nucleus

8364:ppp2r5a
gene id: 8364:ppp2r5a
uniprot id: Q0IIU9
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

8364:t2r10
gene id: 8364:t2r10
uniprot id: Q2AB71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:LOC100497157
gene id: 8364:LOC100497157
uniprot id: Q6P8D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8364:mtmr6
gene id: 8364:mtmr6
uniprot id: A0A8J0QWI8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:sgcz
gene id: 8364:sgcz
uniprot id: A0A8J1J3J5
uniprot id: F6YTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

8364:hsd17b3
gene id: 8364:hsd17b3
uniprot id: A0A8J0SPN7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:metap2
gene id: 8364:metap2
uniprot id: Q28F92
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

8364:hbg1
gene id: 8364:hbg1
uniprot id: P07429
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

8364:gast
gene id: 8364:gast
uniprot id: F6W277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

8364:slc35e4
gene id: 8364:slc35e4
uniprot id: F6WN93
names: Subcellular Location Annotation
messages: Membrane

8364:cox7a2
gene id: 8364:cox7a2
uniprot id: A4QND9
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

8364:map3k13
gene id: 8364:map3k13
uniprot id: F7BQB0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

8364:ccz1b
gene id: 8364:ccz1b
uniprot id: A0A6I8QBI0
uniprot id: A0A8J0T5S7
uniprot id: F7DNC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCZ1 family.
messages: Lysosome membrane

8364:atad2
gene id: 8364:atad2
uniprot id: A0A6I8RDE6
uniprot id: A0A8J1JQP9
names: Similarity
messages: Belongs to the AAA ATPase family.

8364:LOC101734580
gene id: 8364:LOC101734580
uniprot id: A0A8J0SEI5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

8364:arl3l2
gene id: 8364:arl3l2
uniprot id: A0A6I8Q1W7
uniprot id: F7BXL7
uniprot id: F7C0Y2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse
messages: centrosome

8364:ntsr2
gene id: 8364:ntsr2
uniprot id: A0A6I8S4R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100498108
gene id: 8364:LOC100498108
uniprot id: A0A6I8QRE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

8364:tbce
gene id: 8364:tbce
uniprot id: Q28EJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

8364:hnf1b
gene id: 8364:hnf1b
uniprot id: A0A8J0SYI4
uniprot id: F6XA53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

8364:acaa2
gene id: 8364:acaa2
uniprot id: A0A6I8RGB7
uniprot id: F6WDA6
uniprot id: Q0VGV6
names: Similarity
messages: Belongs to the PIH1 family.
messages: Belongs to the thiolase-like superfamily. Thiolase family.

8364:b4galnt2
gene id: 8364:b4galnt2
uniprot id: A0A6I8QM48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

8364:LOC116408737
gene id: 8364:LOC116408737
uniprot id: A0A6I8QCA3
names: Similarity
messages: Belongs to the cystatin family.

8364:LOC100493846
gene id: 8364:LOC100493846
uniprot id: A0A8J0QY97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:crisp1.6
gene id: 8364:crisp1.6
uniprot id: A0A8J0QIW9
names: Similarity
messages: Belongs to the CRISP family.

8364:marchf8
gene id: 8364:marchf8
uniprot id: Q28IK8
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle membrane
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of cd86 and MHC class II proteins, such as hla-dr alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies.
messages: Early endosome membrane
messages: Lysosome membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

8364:crot
gene id: 8364:crot
uniprot id: B5DEC4
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

8364:MGC107841
gene id: 8364:MGC107841
uniprot id: F7CJW9
uniprot id: Q5BKM7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8364:kcnh7
gene id: 8364:kcnh7
uniprot id: A0A6I8QVR8
uniprot id: A0A8J1ITV3
uniprot id: A0A8J1ITW3
uniprot id: A0A8J1IW94
names: Subcellular Location Annotation
messages: Membrane

8364:clic1
gene id: 8364:clic1
uniprot id: Q6PBD0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

8364:tom1l2
gene id: 8364:tom1l2
uniprot id: A0A6I8QDH2
uniprot id: A0A6I8S4V2
uniprot id: A0A6I8SE74
uniprot id: A0A6I8SFW0
uniprot id: A0A8J0R567
uniprot id: A0A8J0R7F0
uniprot id: A0A8J1IWB6
names: Similarity
messages: Belongs to the TOM1 family.

8364:bcap29
gene id: 8364:bcap29
uniprot id: A0A803J2I7
uniprot id: B5DEU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

8364:neu3.1
gene id: 8364:neu3.1
uniprot id: K0PUS8
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

8364:vps4a
gene id: 8364:vps4a
uniprot id: A0A6I8RDL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8364:LOC100495326
gene id: 8364:LOC100495326
uniprot id: A0A6I8QWK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8364:cpne9
gene id: 8364:cpne9
uniprot id: L7MUJ7
names: Similarity
messages: Belongs to the copine family.

8364:LOC100490663
gene id: 8364:LOC100490663
uniprot id: A0A6I8QJD3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:acer3
gene id: 8364:acer3
uniprot id: A8E5U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

8364:baiap2
gene id: 8364:baiap2
uniprot id: A0A6I8R0T5
uniprot id: A0A6I8R269
uniprot id: A0A6I8S083
uniprot id: A0A8J0SPN1
uniprot id: A0A8J0SWQ3
uniprot id: A0A8J0SWQ8
uniprot id: A0A8J0SYL3
uniprot id: A0A8J0SZ60
uniprot id: A0A8J0SZV1
uniprot id: A0A8J0T6I0
uniprot id: A0A8J1IW81
uniprot id: B2GU87
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

8364:piwil2
gene id: 8364:piwil2
uniprot id: A0A8J0SGF1
uniprot id: A8KBF3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the argonaute family.
messages: Belongs to the argonaute family. Piwi subfamily.
messages: Component of the PET complex.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' piwil4. Piwil2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded. Required for piwil4/miwi2 nuclear localization and association with secondary piRNAs antisense. Represses circadian rhythms by promoting the stability and activity of core clock components BMAL1 and CLOCK (By similarity).
messages: Expressed in oocytes, testis and liver (at protein level).
messages: Methylated on arginine residues; required for the interaction with Tudor domain-containing protein and subsequent localization to the meiotic nuage, also named P granule.
messages: Nucleus

8364:rpa1
gene id: 8364:rpa1
uniprot id: B7ZUB9
uniprot id: Q5FW17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Component of the heterotrimeric canonical replication protein A complex (RPA). Interacts with rpain-a (By similarity).
messages: Nucleus
messages: PML body

8364:dnajc2
gene id: 8364:dnajc2
uniprot id: Q6P2Y3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity).
messages: Component of ribosome-associated complex (RAC).
messages: Nucleus
messages: cytosol

8364:LOC105947356
gene id: 8364:LOC105947356
uniprot id: A0A8J0STX5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC100498444
gene id: 8364:LOC100498444
uniprot id: A0A8J1IZP2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ccn3
gene id: 8364:ccn3
uniprot id: A0A6I8Q5Y4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:gbx2.1
gene id: 8364:gbx2.1
uniprot id: F6TB41
names: Subcellular Location Annotation
messages: Nucleus

8364:tuba1a
gene id: 8364:tuba1a
uniprot id: F6YT71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8364:cc2d1b
gene id: 8364:cc2d1b
uniprot id: A0A6I8SHI7
uniprot id: A0A8J1JIG3
names: Similarity
messages: Belongs to the CC2D1 family.

8364:LOC100490322
gene id: 8364:LOC100490322
uniprot id: A0A8J1JL36
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane

8364:hacl1
gene id: 8364:hacl1
uniprot id: A0A6I8S292
uniprot id: A0A803KHJ1
uniprot id: F7B5Z2
names: Similarity
messages: Belongs to the TPP enzyme family.

8364:mrpl12
gene id: 8364:mrpl12
uniprot id: A0A803KKS4
uniprot id: F6QQ99
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

8364:zfyve26
gene id: 8364:zfyve26
uniprot id: A0A6I8QEX4
uniprot id: F6PZZ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
messages: Midbody
messages: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

8364:LOC116412045
gene id: 8364:LOC116412045
uniprot id: A0A8J1JTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:slc35a4
gene id: 8364:slc35a4
uniprot id: A0A803KCL2
uniprot id: A4IHW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Mediates the transport of CDP-ribitol (By similarity). Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity).
messages: Membrane

8364:LOC105945311
gene id: 8364:LOC105945311
uniprot id: A0A8J1JLA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:acrbpl
gene id: 8364:acrbpl
uniprot id: A0A8J1JXD0
names: Subcellular Location Annotation
messages: acrosome

8364:LOC116408818
gene id: 8364:LOC116408818
uniprot id: A0A8J1J6K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

8364:runx1
gene id: 8364:runx1
uniprot id: A0A6I8SXC6
uniprot id: A0A803JCD4
names: Subcellular Location Annotation
messages: Nucleus

8364:rnf10
gene id: 8364:rnf10
uniprot id: A0A6I8PPQ3
uniprot id: Q6P1V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

8364:cog3
gene id: 8364:cog3
uniprot id: A0A6I8SWB7
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

8364:apoh
gene id: 8364:apoh
uniprot id: A0A803J8P5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:kpna3
gene id: 8364:kpna3
uniprot id: Q28EX2
names: Similarity
messages: Belongs to the importin alpha family.

8364:fut6.2
gene id: 8364:fut6.2
uniprot id: F6SLM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8364:amt
gene id: 8364:amt
uniprot id: A0A6I8QE17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

8364:LOC105948087
gene id: 8364:LOC105948087
uniprot id: A0A8J1JUK0
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:LOC105945344
gene id: 8364:LOC105945344
uniprot id: A0A8J0SCF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:slc9a5
gene id: 8364:slc9a5
uniprot id: A0A6I8QMD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

8364:panx3
gene id: 8364:panx3
uniprot id: F7D9M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

8364:LOC116407953
gene id: 8364:LOC116407953
uniprot id: A0A803JDL5
names: Subcellular Location Annotation
messages: Nucleus

8364:gipc2
gene id: 8364:gipc2
uniprot id: F7EF27
names: Similarity
messages: Belongs to the GIPC family.

8364:LOC101734133
gene id: 8364:LOC101734133
uniprot id: W0RZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101734900
gene id: 8364:LOC101734900
uniprot id: F6XTM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:hace1
gene id: 8364:hace1
uniprot id: Q28BK1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division.
messages: Endoplasmic reticulum
messages: Golgi stack membrane

8364:smad9
gene id: 8364:smad9
uniprot id: Q6DIZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8364:ddx47
gene id: 8364:ddx47
uniprot id: F7DX11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Cytoplasm
messages: Nucleus

8364:kpna4
gene id: 8364:kpna4
uniprot id: A0A6I8RYH0
names: Similarity
messages: Belongs to the importin alpha family.

8364:frem3
gene id: 8364:frem3
uniprot id: A0A6I8SNZ5
names: Similarity
messages: Belongs to the FRAS1 family.

8364:cartpt
gene id: 8364:cartpt
uniprot id: A0A6I8PSB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

8364:cck
gene id: 8364:cck
uniprot id: A0A803J912
uniprot id: A0A8J1JTN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

8364:actn3
gene id: 8364:actn3
uniprot id: B4F6M1
names: Similarity
messages: Belongs to the alpha-actinin family.

8364:stk35
gene id: 8364:stk35
uniprot id: Q6GLH7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:mex3b
gene id: 8364:mex3b
uniprot id: F6RXP6
names: Subcellular Location Annotation
messages: Nucleus

8364:aldh1a3
gene id: 8364:aldh1a3
uniprot id: A0A6I8SYW2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:sstr2
gene id: 8364:sstr2
uniprot id: A0A803JIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

8364:klf8
gene id: 8364:klf8
uniprot id: F6U4S8
names: Similarity
messages: Belongs to the CCDC90 family.

8364:mc5r
gene id: 8364:mc5r
uniprot id: A4IIF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

8364:nusap1
gene id: 8364:nusap1
uniprot id: A0A8J0SUY2
uniprot id: B2GTZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUSAP family.
messages: Cytoplasm

8364:LOC105946942
gene id: 8364:LOC105946942
uniprot id: A0A8J1JC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

8364:plk2
gene id: 8364:plk2
uniprot id: A4QNQ0
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

8364:clk3
gene id: 8364:clk3
uniprot id: Q5I092
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:ina
gene id: 8364:ina
uniprot id: F7DRR7
names: Similarity
messages: Belongs to the intermediate filament family.

8364:tet3
gene id: 8364:tet3
uniprot id: A0A8J1J654
uniprot id: A0JP82
uniprot id: F7B8K9
uniprot id: F7BTK8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Binds target DNA that contains at least one unmethylated cytosine via the CXXC-type zinc-finger domain.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not require its enzyme activity.
messages: Nucleus
messages: The zinc ions have a structural role.

8364:fdft1
gene id: 8364:fdft1
uniprot id: B5DE21
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

8364:LOC100495962
gene id: 8364:LOC100495962
uniprot id: A0A8J0QZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8364:wdfy1
gene id: 8364:wdfy1
uniprot id: A0A6I8SB76
uniprot id: A0A8J0R6N4
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

8364:slc48a1
gene id: 8364:slc48a1
uniprot id: F7DAV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
messages: Lysosome membrane
messages: Membrane

8364:mapk8ip3
gene id: 8364:mapk8ip3
uniprot id: A0A6I8Q4M2
uniprot id: A0A6I8SIJ4
uniprot id: A0A8J0SMZ1
uniprot id: A0A8J0SMZ8
uniprot id: A0A8J0SN04
uniprot id: A0A8J0SV38
uniprot id: A0A8J0SV42
uniprot id: A0A8J0SV47
uniprot id: A0A8J0SWY1
uniprot id: A0A8J0SWY5
uniprot id: A0A8J0SXJ9
uniprot id: A0A8J0SXK4
uniprot id: A0A8J0SXL0
uniprot id: A0A8J0SY77
uniprot id: A0A8J0SY84
uniprot id: A0A8J0SY88
uniprot id: B3DLW5
uniprot id: F7AT94
uniprot id: L7N392
names: Similarity
messages: Belongs to the JIP scaffold family.

8364:acer1
gene id: 8364:acer1
uniprot id: A0A7D9NJR1
uniprot id: F6X856
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Belongs to the pecanex family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

8364:calr3
gene id: 8364:calr3
uniprot id: F7E4B5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen
messages: Monomer.

8364:KEG17 p12
gene id: 8364:KEG17_p12
uniprot id: Q5G7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

8364:kcnmb4
gene id: 8364:kcnmb4
uniprot id: A0A8J0PJS2
uniprot id: F7BBP2
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100485854
gene id: 8364:LOC100485854
uniprot id: A0A8J0T3Y8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:p2rx1
gene id: 8364:p2rx1
uniprot id: A0A6I8RW96
uniprot id: A0A8J0QLV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8364:kdelr3
gene id: 8364:kdelr3
uniprot id: Q66JF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

8364:LOC116407627
gene id: 8364:LOC116407627
uniprot id: A0A8J1IUA4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:gfra3
gene id: 8364:gfra3
uniprot id: F7B6N4
names: Similarity
messages: Belongs to the GDNFR family.

8364:alox12b
gene id: 8364:alox12b
uniprot id: Q5FW07
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:slc4a11
gene id: 8364:slc4a11
uniprot id: A0A8J0QSA7
uniprot id: A0A8J1J260
uniprot id: F7DFG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

8364:apold1
gene id: 8364:apold1
uniprot id: Q0V9X6
names: Similarity
messages: Belongs to the apolipoprotein L family.

8364:hey1
gene id: 8364:hey1
uniprot id: Q66KK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEY family.
messages: Downstream effector of Notch signaling. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Acts as a suppressor of neurogenesis by antagonizing proneural gene function. Functions during floorplate development. Plays a role in pronephros formation in the inhibition of distal tubule and duct cell fates and the promotion of glomus and proximal tubule formation (By similarity).
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA in the form of homodimer or more strongly as a heterodimer with hes1/hairy1 or hes4/hairy2b. Also weakly interacts with the bHLH proteins hes2, neurod1 and neurod4/ath3. Interacts (via Orange domain) with ccdc89/boip (via C-terminus) (By similarity).
messages: Nucleus
messages: The C-terminal YRPW motif is not required for transcriptional repressor activity and is unable to recruit groucho.
messages: The Orange domain, downstream sequence and the bHLH are required for efficient heterodimerization with hes/hairy proteins, and for transcriptional repressor activity.

8364:psmc5
gene id: 8364:psmc5
uniprot id: Q6P380
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

8364:xpo5.2
gene id: 8364:xpo5.2
uniprot id: A0A7D9NK13
names: Subcellular Location Annotation
messages: Cytoplasm

8364:txnrd2
gene id: 8364:txnrd2
uniprot id: A0A8J0QA84
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

8364:LOC116406473
gene id: 8364:LOC116406473
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:fras1
gene id: 8364:fras1
uniprot id: A0A6I8QBY6
uniprot id: A0A6I8QTE1
names: Similarity
messages: Belongs to the FRAS1 family.

8364:ydjc
gene id: 8364:ydjc
uniprot id: A0A8J0SJ02
uniprot id: A0A8J1J6U1
uniprot id: A0A8J1J6V0
uniprot id: Q6DJC2
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

8364:fbxo34
gene id: 8364:fbxo34
uniprot id: A0A6I8Q0K6
uniprot id: A9JTT0
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

8364:heg1
gene id: 8364:heg1
uniprot id: A0A8J1IVX2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:plin2
gene id: 8364:plin2
uniprot id: A0A6I8SFP3
uniprot id: Q6P7Z5
names: Similarity
messages: Belongs to the perilipin family.

8364:hat1
gene id: 8364:hat1
uniprot id: A0A8J0SY31
uniprot id: F6Q2B6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

8364:adh1c
gene id: 8364:adh1c
uniprot id: A0A8J1JFR5
uniprot id: Q5BKM0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8364:cnot7
gene id: 8364:cnot7
uniprot id: A0A8J1JLN1
uniprot id: A4II96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAF1 family.
messages: Binds 2 divalent metal cations per subunit with RNAase activity being higher in presence of Mn(2+) than of Mg(2+) or Co(2+).
messages: Component of the CCR4-NOT complex.
messages: Cytoplasm
messages: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression.
messages: Nucleus

8364:adipor1
gene id: 8364:adipor1
uniprot id: A0A8J0SK40
uniprot id: Q66KJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8364:slc7a11
gene id: 8364:slc7a11
uniprot id: A0A6I8R577
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

8364:mfsd4a
gene id: 8364:mfsd4a
uniprot id: Q5BIZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8364:aco1
gene id: 8364:aco1
uniprot id: A0A6I8QDE2
uniprot id: B5DE51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: cytosol

8364:LOC100490615
gene id: 8364:LOC100490615
uniprot id: A0A8J0QVV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

8364:pdhb
gene id: 8364:pdhb
uniprot id: Q5BKI5
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

8364:fam214b
gene id: 8364:fam214b
uniprot id: A0A6I8RK85
names: Similarity
messages: Belongs to the FAM214 family.

8364:LOC116412179
gene id: 8364:LOC116412179
uniprot id: A0A8J1JUX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:elavl4
gene id: 8364:elavl4
uniprot id: A0A6I8QFB6
uniprot id: A0A6I8QXP4
uniprot id: A0A6I8RJW0
uniprot id: A0A6I8T2K7
uniprot id: A0A803K697
uniprot id: A0A8J0SAV7
uniprot id: A0A8J0SAW0
uniprot id: A0A8J0SHG4
uniprot id: A0A8J0SHH0
uniprot id: A0A8J0SJ52
uniprot id: A0A8J0SKA2
uniprot id: A0A8J0SKE1
uniprot id: A4QNI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (By similarity). Plays a role in the regulation of mRNA stability, alternative splicing and translation (By similarity). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Mainly plays a role in neuron-specific RNA processing (By similarity).
messages: axon
messages: dendrite
messages: growth cone

8364:lin28a
gene id: 8364:lin28a
uniprot id: A0A8J0SCH7
uniprot id: B4F6Z2
uniprot id: F7DXS7
uniprot id: G1K3F3
uniprot id: Q5EB47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-28 family.
messages: Belongs to the lipin family.
messages: Cytoplasm
messages: Monomer.
messages: P-body
messages: RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Suppressor of microRNA (miRNA) biogenesis, including that of let-7. Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).
messages: Rough endoplasmic reticulum
messages: Stress granule
messages: The CCHC zinc fingers interact with the GGAG motif at the 3' end of let-7 miRNAs precursors, more generally they bind the 5'-NGNNG-3' consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5' end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members (By similarity).
messages: nucleolus

8364:bak1
gene id: 8364:bak1
uniprot id: A0A8J1J6P8
uniprot id: A0A8J1J7R7
names: Similarity
messages: Belongs to the Bcl-2 family.

8364:lefty
gene id: 8364:lefty
uniprot id: B3DLA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

8364:LOC100497127
gene id: 8364:LOC100497127
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:lpcat1
gene id: 8364:lpcat1
uniprot id: F6S3K0
uniprot id: F6TE47
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

8364:uxs1
gene id: 8364:uxs1
uniprot id: Q6DF08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
messages: Golgi stack membrane
messages: Homodimer and homotetramer.

8364:prps2
gene id: 8364:prps2
uniprot id: Q5XGI0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3-bisphosphoglyceride or GDP (By similarity).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).

8364:pou2f2
gene id: 8364:pou2f2
uniprot id: A0A6I8QFT2
uniprot id: A0A6I8S1B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

8364:LOC100492603
gene id: 8364:LOC100492603
uniprot id: A0A8J1JG64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8364:prickle3
gene id: 8364:prickle3
uniprot id: A0A803K7N2
uniprot id: A0A8J0QRA0
uniprot id: A0A8J0R1P6
uniprot id: A0A8J0SUE8
uniprot id: A0A8J1IN69
uniprot id: A0A8J1IR98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cell membrane
messages: Membrane

8364:grm7
gene id: 8364:grm7
uniprot id: A8KBG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8364:foxn2
gene id: 8364:foxn2
uniprot id: Q28F43
names: Subcellular Location Annotation
messages: Nucleus

8364:nog
gene id: 8364:nog
uniprot id: F6RNY4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Secreted

8364:nxpe3
gene id: 8364:nxpe3
uniprot id: A0A7D9NKL1
uniprot id: A0A8J0R1B9
names: Similarity
messages: Belongs to the NXPE family.

8364:LOC100497460
gene id: 8364:LOC100497460
uniprot id: A0A803KDQ6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:nfib
gene id: 8364:nfib
uniprot id: A0A6I8RST3
uniprot id: A0A6I8SDK3
uniprot id: A0A6I8SJH4
uniprot id: A0A803KHX6
uniprot id: A0A8J0SF10
uniprot id: F6T394
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8364:pou6f1
gene id: 8364:pou6f1
uniprot id: A0A8J0Q980
uniprot id: A0A8J0SEA9
uniprot id: A8E4V1
uniprot id: F7C2Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8364:hspd1
gene id: 8364:hspd1
uniprot id: A0A803KIS9
uniprot id: F6QRN4
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

8364:LOC101733443
gene id: 8364:LOC101733443
uniprot id: A0A803JGG3
uniprot id: A0A8J1JFB5
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC496693
gene id: 8364:LOC496693
uniprot id: A0A8J1IRJ0
uniprot id: F7BEB2
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

8364:kif20a
gene id: 8364:kif20a
uniprot id: A0A6I8Q3P1
uniprot id: A0A6I8R349
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:LOC116406764
gene id: 8364:LOC116406764
uniprot id: A0A8J1IPH8
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:liph
gene id: 8364:liph
uniprot id: Q5XGE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid (By similarity). Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) (By similarity).
messages: Secreted

8364:gby
gene id: 8364:gby
uniprot id: A0A6I8Q198
uniprot id: A0A8J0QUY2
names: Similarity
messages: Belongs to the globin family.

8364:LOC100493745
gene id: 8364:LOC100493745
uniprot id: A0A8J1JIW7
names: Subcellular Location Annotation
messages: Nucleus

8364:hdac8
gene id: 8364:hdac8
uniprot id: A0A6I8RNR5
uniprot id: A0A8J0SSE5
uniprot id: B1H369
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Binds 1 divalent metal cation per subunit.
messages: Chromosome
messages: Cytoplasm
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
messages: Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors.
messages: Nucleus

8364:vps35l
gene id: 8364:vps35l
uniprot id: F6W9V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

8364:tcaf1
gene id: 8364:tcaf1
uniprot id: A0A6I8PYL8
uniprot id: A0A8J0QLN8
names: Similarity
messages: Belongs to the TCAF family.

8364:zp4.2
gene id: 8364:zp4.2
uniprot id: A0A6I8SE61
uniprot id: A0A8J0QTK0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100498440
gene id: 8364:LOC100498440
uniprot id: A0A6I8R4V7
uniprot id: A0A803JD31
uniprot id: A0A8J0QY68
uniprot id: A0A8J0QYR5
uniprot id: A0A8J0R0A6
uniprot id: A0A8J0R2E2
uniprot id: A0A8J0R356
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

8364:prodh2
gene id: 8364:prodh2
uniprot id: A0A803JR64
uniprot id: A0A8J1IW27
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

8364:nrn1l
gene id: 8364:nrn1l
uniprot id: A0A803J9U9
names: Similarity
messages: Belongs to the neuritin family.

8364:toe1
gene id: 8364:toe1
uniprot id: B0JZ51
uniprot id: F6VJ53
names: Similarity
messages: Belongs to the CAF1 family.

8364:bcat2
gene id: 8364:bcat2
uniprot id: Q6DIN6
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

8364:LOC100498582
gene id: 8364:LOC100498582
uniprot id: A0A8J0T5F9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:kpna1
gene id: 8364:kpna1
uniprot id: Q6P4X0
names: Similarity
messages: Belongs to the importin alpha family.

8364:lemd1
gene id: 8364:lemd1
uniprot id: A0A8J0SFL4
uniprot id: A0A8J0SGP8
uniprot id: A0A8J0SGS6
uniprot id: A0A8J0SGT1
names: Similarity
messages: Belongs to the LEM family.

8364:fam151a
gene id: 8364:fam151a
uniprot id: F6R783
names: Similarity
messages: Belongs to the FAM151 family.

8364:sfxn5
gene id: 8364:sfxn5
uniprot id: A0A6I8QRK3
uniprot id: Q6DJ23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

8364:sec61g
gene id: 8364:sec61g
uniprot id: F6TPF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:dtnb
gene id: 8364:dtnb
uniprot id: A0A6I8QQ65
uniprot id: A0A6I8RCF6
uniprot id: A0A6I8RZC6
uniprot id: A0A803J5S5
uniprot id: A0A803K564
uniprot id: A0A8J1JIS5
uniprot id: A0A8J1JL78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

8364:lrp2
gene id: 8364:lrp2
uniprot id: A0A6I8RWX3
uniprot id: A0A6I8SPQ9
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cdx4
gene id: 8364:cdx4
uniprot id: Q90X88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

8364:kcne3
gene id: 8364:kcne3
uniprot id: A0A803J9E2
names: Similarity
messages: Belongs to the potassium channel KCNE family.

8364:selenop1
gene id: 8364:selenop1
uniprot id: A0A8J0QEF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein P family.
messages: Secreted

8364:LOC116409528
gene id: 8364:LOC116409528
uniprot id: A0A803KF61
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100493091
gene id: 8364:LOC100493091
uniprot id: A0A803KDS1
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

8364:c2orf49
gene id: 8364:c2orf49
uniprot id: F7BDK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

8364:LOC101730373
gene id: 8364:LOC101730373
uniprot id: F7CNE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

8364:brms1
gene id: 8364:brms1
uniprot id: A0A803K4R0
names: Subcellular Location Annotation
messages: Nucleus

8364:psmd5
gene id: 8364:psmd5
uniprot id: B1H2W9
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

8364:anapc10
gene id: 8364:anapc10
uniprot id: Q28GX7
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

8364:t2r36
gene id: 8364:t2r36
uniprot id: Q2AB49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:sike1
gene id: 8364:sike1
uniprot id: A0A6I8S4Q9
uniprot id: A0A8J0SCD1
uniprot id: Q5I033
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIKE family.
messages: Cytoplasm
messages: Suppressor of IKK-epsilon.

8364:nrm
gene id: 8364:nrm
uniprot id: A0A8J0QVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

8364:ip6k2
gene id: 8364:ip6k2
uniprot id: F7D664
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8364:eme1
gene id: 8364:eme1
uniprot id: Q0V9Y7
names: Similarity
messages: Belongs to the EME1/MMS4 family.

8364:cplx1
gene id: 8364:cplx1
uniprot id: A4IHC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

8364:hsd17b12
gene id: 8364:hsd17b12
uniprot id: Q28IU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
messages: Endoplasmic reticulum membrane

8364:mmrn1
gene id: 8364:mmrn1
uniprot id: A0A803KGC2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101731654
gene id: 8364:LOC101731654
uniprot id: A0A8J1IPX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sptlc3
gene id: 8364:sptlc3
uniprot id: A0A6I8S6M1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

8364:LOC116407928
gene id: 8364:LOC116407928
uniprot id: A0A8J1IZ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gse1
gene id: 8364:gse1
uniprot id: F6SL08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

8364:ano4
gene id: 8364:ano4
uniprot id: A0A8J0SAE7
uniprot id: A0A8J0SGT7
uniprot id: A0A8J1JDK2
uniprot id: F6ZLF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

8364:rrbp1
gene id: 8364:rrbp1
uniprot id: F6YU00
names: Subcellular Location Annotation
messages: Membrane

8364:tmem41b
gene id: 8364:tmem41b
uniprot id: A0A6I8PL23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

8364:LOC101735136
gene id: 8364:LOC101735136
uniprot id: A0A8J0R254
uniprot id: A0A8J0T301
uniprot id: A0A8J1JF03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:sox17b.2
gene id: 8364:sox17b.2
uniprot id: Q6GLH8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts (via C-terminus) with ctnnb1/beta-catenin (via Armadillo repeats); this interaction is required for inhibition of wnt-signaling.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription activator. Doesn't appear to bind to the consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin-mediated signaling (By similarity).

8364:tceanc2
gene id: 8364:tceanc2
uniprot id: A0A8J0PJK7
names: Subcellular Location Annotation
messages: Nucleus

8364:tacr1
gene id: 8364:tacr1
uniprot id: A0A6I8RA90
uniprot id: A8WGF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:lamb2
gene id: 8364:lamb2
uniprot id: A0A6I8R8X6
uniprot id: A0A6I8R9J4
uniprot id: F7E8X3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: basement membrane

8364:scnn1d
gene id: 8364:scnn1d
uniprot id: F6VMZ3
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8364:dtymk
gene id: 8364:dtymk
uniprot id: Q6DF36
names: Similarity
messages: Belongs to the thymidylate kinase family.

8364:rad51
gene id: 8364:rad51
uniprot id: A4IH92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

8364:LOC105945567
gene id: 8364:LOC105945567
uniprot id: A0A8J0SC40
names: Subcellular Location Annotation
messages: Membrane

8364:ezr
gene id: 8364:ezr
uniprot id: Q5BJ89
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8364:ilvbl
gene id: 8364:ilvbl
uniprot id: A0A6I8RN08
uniprot id: B0JZX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

8364:LOC116409620
gene id: 8364:LOC116409620
uniprot id: A0A8J1J8L9
names: Subcellular Location Annotation
messages: Membrane

8364:prkar1b
gene id: 8364:prkar1b
uniprot id: A0A8J1IV38
uniprot id: Q0P4Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

8364:gng7
gene id: 8364:gng7
uniprot id: Q28H40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:actl6b
gene id: 8364:actl6b
uniprot id: A7MC66
names: Similarity
messages: Belongs to the actin family.

8364:lhx3
gene id: 8364:lhx3
uniprot id: A0A803J6Z0
uniprot id: A0A803JMR6
uniprot id: A0A8J1IQI6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100486273
gene id: 8364:LOC100486273
uniprot id: A0A8J1IT20
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:thbs2
gene id: 8364:thbs2
uniprot id: A0A6I8RWI7
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101730379
gene id: 8364:LOC101730379
uniprot id: A0A1B8Y8M8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

8364:gpi
gene id: 8364:gpi
uniprot id: F6ZHL4
names: Similarity
messages: Belongs to the GPI family.

8364:cyb5b
gene id: 8364:cyb5b
uniprot id: Q28EL9
names: Similarity
messages: Belongs to the cytochrome b5 family.

8364:trmt6
gene id: 8364:trmt6
uniprot id: Q6DF58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

8364:msmb.1
gene id: 8364:msmb.1
uniprot id: A0A8J0QQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8364:LOC100496615
gene id: 8364:LOC100496615
uniprot id: A0A8J0QJM0
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

8364:LOC101732407.2
gene id: 8364:LOC101732407.2
uniprot id: A0A8J0SD16
names: Subcellular Location Annotation
messages: Nucleus

8364:baz2b
gene id: 8364:baz2b
uniprot id: A0A6I8SEY5
uniprot id: A0A8J0QN67
uniprot id: A0A8J0SP59
uniprot id: A0A8J0SP64
uniprot id: A0A8J0SP70
uniprot id: A0A8J0SW73
uniprot id: A0A8J0SW78
uniprot id: A0A8J0SW84
uniprot id: A0A8J0SW90
uniprot id: A0A8J0SY22
uniprot id: A0A8J0SY26
uniprot id: A0A8J0SY33
uniprot id: A0A8J0SYP4
uniprot id: A0A8J0SYP9
uniprot id: A0A8J0SYQ4
uniprot id: A0A8J0SZC0
uniprot id: A0A8J0SZD1
names: Similarity
messages: Belongs to the WAL family.

8364:mast3
gene id: 8364:mast3
uniprot id: A0A6I8QSJ0
uniprot id: A0A8J0SDA4
uniprot id: A0A8J0T3J2
uniprot id: A0A8J1JT42
uniprot id: A0A8J1JT47
uniprot id: A0A8J1JT67
uniprot id: A0A8J1JVN3
uniprot id: A0A8J1JWW8
uniprot id: A0A8J1JWX3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

8364:grik3
gene id: 8364:grik3
uniprot id: A0A6I8RI88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:ogfod1
gene id: 8364:ogfod1
uniprot id: A0A6I8RM06
names: Similarity
messages: Belongs to the TPA1 family.

8364:cd82
gene id: 8364:cd82
uniprot id: Q6P4W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:t2r37
gene id: 8364:t2r37
uniprot id: Q2AB48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:cat.3
gene id: 8364:cat.3
uniprot id: A0A8J1JDF7
uniprot id: Q5I0T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

8364:LOC108648175
gene id: 8364:LOC108648175
uniprot id: A0A8J0T5S4
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:six1
gene id: 8364:six1
uniprot id: F6Y0S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

8364:LOC116408821
gene id: 8364:LOC116408821
uniprot id: A0A8J1J479
uniprot id: A0A8J1J6L3
uniprot id: A0A8J1J7N0
names: Subcellular Location Annotation
messages: Membrane

8364:mmut
gene id: 8364:mmut
uniprot id: A0A8J0R4M0
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

8364:ddx24
gene id: 8364:ddx24
uniprot id: A0A6I8SZ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:lias
gene id: 8364:lias
uniprot id: A0A8J1JDD2
uniprot id: Q5M8W4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

8364:slc25a29
gene id: 8364:slc25a29
uniprot id: A0A8J1JXS7
uniprot id: A4IIW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:LOC105946285
gene id: 8364:LOC105946285
uniprot id: A0A8J0S6Q8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pik3c3
gene id: 8364:pik3c3
uniprot id: A0A8J1J1B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

8364:slc12a6
gene id: 8364:slc12a6
uniprot id: A0A6I8QM56
uniprot id: A0A6I8SVS0
uniprot id: A0A8J0SS17
uniprot id: A0A8J1JKW6
uniprot id: Q0IHX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

8364:LOC100127850
gene id: 8364:LOC100127850
uniprot id: Q07FY4
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

8364:dnal4
gene id: 8364:dnal4
uniprot id: Q6DIF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

8364:LOC116410902
gene id: 8364:LOC116410902
uniprot id: A0A8J1JKF3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:fam160a1
gene id: 8364:fam160a1
uniprot id: F7DN00
names: Similarity
messages: Belongs to the FHIP family.

8364:calr
gene id: 8364:calr
uniprot id: Q6NVT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

8364:akr1c2
gene id: 8364:akr1c2
uniprot id: Q0VFN9
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8364:LOC100494295
gene id: 8364:LOC100494295
uniprot id: A0A8J0QXB0
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:rhobtb1
gene id: 8364:rhobtb1
uniprot id: F6VE55
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8364:timm23
gene id: 8364:timm23
uniprot id: Q5XH94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of timm23, timm17 and timm50. The complex interacts with the timm44 component of the PAM complex (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

8364:LOC100490380
gene id: 8364:LOC100490380
uniprot id: A0A803J8Y8
uniprot id: A0A8J0QWK4
uniprot id: A0A8J0QZM7
uniprot id: F6UBN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

8364:LOC100490612
gene id: 8364:LOC100490612
uniprot id: A0A8J1IRU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:tmtc4
gene id: 8364:tmtc4
uniprot id: B2GUG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

8364:tom1
gene id: 8364:tom1
uniprot id: Q28D28
names: Similarity
messages: Belongs to the TOM1 family.

8364:use1
gene id: 8364:use1
uniprot id: B1H3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:calu
gene id: 8364:calu
uniprot id: A0A8J0QKE8
uniprot id: F6RHF9
uniprot id: Q28BT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Interacts with ggcx.
messages: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity).
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

8364:ltb4r2
gene id: 8364:ltb4r2
uniprot id: A0A803JTA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC108644798
gene id: 8364:LOC108644798
uniprot id: A0A8J1JQW1
names: Subcellular Location Annotation
messages: Membrane

8364:ndufb4
gene id: 8364:ndufb4
uniprot id: A4QNM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8364:acadvl
gene id: 8364:acadvl
uniprot id: A0A803JR71
uniprot id: A0A8J1JFP4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8364:phox2a
gene id: 8364:phox2a
uniprot id: F6X0A4
names: Subcellular Location Annotation
messages: Nucleus

8364:gpr65
gene id: 8364:gpr65
uniprot id: A0A6I8QWZ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:myt1
gene id: 8364:myt1
uniprot id: A0A6I8SAT7
uniprot id: A0A803JF48
uniprot id: A0A8J1IX44
uniprot id: A0A8J1IX93
uniprot id: F7DJG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

8364:dpf1
gene id: 8364:dpf1
uniprot id: A0A6I8R1Y4
uniprot id: A1L1E9
names: Similarity
messages: Belongs to the requiem/DPF family.

8364:hsp90ab1
gene id: 8364:hsp90ab1
uniprot id: Q5BL42
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8364:paip2b
gene id: 8364:paip2b
uniprot id: Q6NTH5
names: Similarity
messages: Belongs to the PAIP2 family.

8364:ubp1
gene id: 8364:ubp1
uniprot id: F6X512
uniprot id: Q5I078
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

8364:slco4a1
gene id: 8364:slco4a1
uniprot id: F6SNS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

8364:LOC100492758
gene id: 8364:LOC100492758
uniprot id: A0A6I8R3A6
names: Similarity
messages: Belongs to the THADA family.

8364:inpp5a.2
gene id: 8364:inpp5a.2
uniprot id: B1WBJ5
uniprot id: F6ZFS5
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

8364:kcnmb2
gene id: 8364:kcnmb2
uniprot id: A0A6I8SAZ8
names: Subcellular Location Annotation
messages: Membrane

8364:fam49b
gene id: 8364:fam49b
uniprot id: A0A6I8SKR5
uniprot id: Q6GLA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

8364:ap2s1
gene id: 8364:ap2s1
uniprot id: Q28GD2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

8364:ttc39b
gene id: 8364:ttc39b
uniprot id: Q28DB0
names: Function
names: Similarity
messages: Belongs to the TTC39 family.
messages: May be involved in lipid metabolism.

8364:ube2w
gene id: 8364:ube2w
uniprot id: Q28FC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrate and DNA repair.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Nucleus

8364:bcdin3d
gene id: 8364:bcdin3d
uniprot id: A0A6I8RVM3
names: Similarity
messages: Belongs to the methyltransferase superfamily.

8364:LOC101735201
gene id: 8364:LOC101735201
uniprot id: A0A6I8PUM5
uniprot id: A0A8J1JGK3
uniprot id: A0A8J1JJ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

8364:myadm
gene id: 8364:myadm
uniprot id: Q6DFR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAL family.
messages: Membrane

8364:LOC100485740
gene id: 8364:LOC100485740
uniprot id: A0A8J0QSI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rpl27a
gene id: 8364:rpl27a
uniprot id: A0A6I8T2M3
uniprot id: A0A8J1JS44
uniprot id: B3DLV5
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

8364:t2r6
gene id: 8364:t2r6
uniprot id: Q2AB75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:fam155a
gene id: 8364:fam155a
uniprot id: A0A803K6T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

8364:zbtb8a.1
gene id: 8364:zbtb8a.1
uniprot id: B1WAZ8
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

8364:galnt2
gene id: 8364:galnt2
uniprot id: A0A6I8S415
uniprot id: A0A8J1JL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:rab3gap1
gene id: 8364:rab3gap1
uniprot id: A0A6I8T0T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

8364:ppox
gene id: 8364:ppox
uniprot id: A0A8J1IPD5
uniprot id: F7B8N5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

8364:LOC100492191
gene id: 8364:LOC100492191
uniprot id: A0A8J1JBX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC394448
gene id: 8364:LOC394448
uniprot id: A0A8J0SX26
uniprot id: Q28GP5
names: Similarity
messages: Belongs to the cyclin family.

8364:tmc7
gene id: 8364:tmc7
uniprot id: A0A6I8Q7D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8364:agl
gene id: 8364:agl
uniprot id: A0A6I8SDS9
uniprot id: F7D922
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

8364:ppp1r3c.1
gene id: 8364:ppp1r3c.1
uniprot id: A9JTM1
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

8364:sbk1
gene id: 8364:sbk1
uniprot id: A0A803JKB1
uniprot id: A4IIN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

8364:LOC101730848
gene id: 8364:LOC101730848
uniprot id: A0A8J0R789
names: Similarity
messages: Belongs to the cyclin family.

8364:tnfrsf19
gene id: 8364:tnfrsf19
uniprot id: F6WFL7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mios
gene id: 8364:mios
uniprot id: F7AU31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane

8364:irf10
gene id: 8364:irf10
uniprot id: A0A8J1IYI7
uniprot id: F6R2V2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:myh2
gene id: 8364:myh2
uniprot id: Q6DFQ6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:tsfm
gene id: 8364:tsfm
uniprot id: A0A8J0QJ02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

8364:cpeb4
gene id: 8364:cpeb4
uniprot id: A0A8J0R1W7
uniprot id: A0A8J1J9Y3
uniprot id: A0A8J1JDH0
uniprot id: F7AUA0
names: Similarity
messages: Belongs to the RRM CPEB family.

8364:pfn1
gene id: 8364:pfn1
uniprot id: B3DLX0
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

8364:naa50
gene id: 8364:naa50
uniprot id: Q5XGA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GNAT subfamily.
messages: Cytoplasm
messages: N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. The relevance of N-epsilon-acetyltransferase activity is however unclear. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin.
messages: Nucleus

8364:LOC100485164
gene id: 8364:LOC100485164
uniprot id: F7D865
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8364:slc6a17
gene id: 8364:slc6a17
uniprot id: F6QY29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:extl3
gene id: 8364:extl3
uniprot id: Q66JH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

8364:LOC100492744
gene id: 8364:LOC100492744
uniprot id: A0A803K8J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

8364:otop1.2
gene id: 8364:otop1.2
uniprot id: A0A6I8STU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:gabrr3
gene id: 8364:gabrr3
uniprot id: F6QTQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:LOC100492272
gene id: 8364:LOC100492272
uniprot id: A0A8J0R0D6
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:proca1
gene id: 8364:proca1
uniprot id: A0A8J1J3U8
names: Subcellular Location Annotation
messages: Secreted

8364:gkap1
gene id: 8364:gkap1
uniprot id: Q5M8L3
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GKAP1 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Golgi apparatus
messages: May play a role in the regulation of insulin-dependent IRS1 tyrosine phosphorylation in adipocytes.

8364:rasgef1b
gene id: 8364:rasgef1b
uniprot id: Q28EC1
names: Function
messages: Guanine nucleotide exchange factor (GEF) with specificity for rap2a and other Ras family proteins (in vitro).

8364:LOC116412266
gene id: 8364:LOC116412266
uniprot id: A0A803JF24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rps19
gene id: 8364:rps19
uniprot id: A0A6I8RJS4
uniprot id: A0A8J0QVR1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

8364:slc16a10
gene id: 8364:slc16a10
uniprot id: A0A7D9NKR6
uniprot id: F7CDR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRAS1 family.
messages: Membrane

8364:n4bp1
gene id: 8364:n4bp1
uniprot id: Q6DJS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP1 family.
messages: Nucleus
messages: PML body
messages: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (By similarity). Has ribonuclease activity (By similarity).
messages: cytosol
messages: nucleolus

8364:LOC116407574
gene id: 8364:LOC116407574
uniprot id: A0A8J1ITN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:rala
gene id: 8364:rala
uniprot id: Q28CF3
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

8364:nodal3.1
gene id: 8364:nodal3.1
uniprot id: Q800B9
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation (By similarity). The unprocessed protein antagonizes bmp-signaling.
messages: Expressed in the dorsal marginal region of late blastula, becoming restricted to the Spemann organizer at the early gastrula stage.
messages: First detected at the blastula stage (stage 8). Expression peaks through the mid-blastula (stage 8.5) to early gastrula (stage 10) and then decreases during gastrulation.
messages: Monomer (By similarity). The propeptide region interacts with bmp4 in a non-covalent manner.
messages: Secreted
messages: The propeptide region is both necessary and sufficient for bmp-inhibitory activity. The propeptide region and the N- and C-terminal thirds of the mature protein are necessary for neural induction activity. Although cleavage doesn't appear essential for activity, residues surrounding the cleavage site are necessary for activity (By similarity).

8364:LOC116408890
gene id: 8364:LOC116408890
uniprot id: A0A8J1J7S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

8364:brms1l
gene id: 8364:brms1l
uniprot id: A4II71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRMS1 family.
messages: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity.
messages: Nucleus

8364:msh2
gene id: 8364:msh2
uniprot id: A0A8J0QMV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

8364:kcnt2l
gene id: 8364:kcnt2l
uniprot id: A0A6I8QLN9
uniprot id: A0A8J0SC64
uniprot id: A0A8J1JBL0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116407800
gene id: 8364:LOC116407800
uniprot id: A0A8J1IYW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:smc1a
gene id: 8364:smc1a
uniprot id: A0A6I8QZH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

8364:mapt
gene id: 8364:mapt
uniprot id: A0A8J0S5B6
uniprot id: A0A8J0S5B9
uniprot id: A0A8J0S9H8
uniprot id: A0A8J0S9I1
uniprot id: A0A8J0SB17
uniprot id: A0A8J0SB20
uniprot id: A0A8J0SBN3
uniprot id: A0A8J0SBN8
uniprot id: A0A8J0SC07
uniprot id: A0A8J0SC12
uniprot id: A0A8J1IWQ4
uniprot id: A0A8J1IWW2
uniprot id: Q0P4W8
names: Subcellular Location Annotation
messages: cytoskeleton

8364:LOC105948083
gene id: 8364:LOC105948083
uniprot id: A0A8J0SW33
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100493300
gene id: 8364:LOC100493300
uniprot id: F7CDE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8364:pnoc
gene id: 8364:pnoc
uniprot id: A8WGY6
uniprot id: F7CDP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

8364:bpi.4
gene id: 8364:bpi.4
uniprot id: A0A8J1IW56
uniprot id: B0BMR6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8364:LOC116412161
gene id: 8364:LOC116412161
uniprot id: A0A8J1JUU4
names: Subcellular Location Annotation
messages: Membrane

8364:twistnb
gene id: 8364:twistnb
uniprot id: F7BDD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: nucleolus

8364:ngrn
gene id: 8364:ngrn
uniprot id: B3DM15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

8364:polr2i
gene id: 8364:polr2i
uniprot id: A0A6I8QYT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

8364:rps15a
gene id: 8364:rps15a
uniprot id: A4IH66
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

8364:tafa5
gene id: 8364:tafa5
uniprot id: A0A6I8S5Z0
uniprot id: A0A803K138
uniprot id: A4II81
names: Similarity
messages: Belongs to the TAFA family.

8364:flt4
gene id: 8364:flt4
uniprot id: A0A6I8RMQ8
uniprot id: A0A8J0SJK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Nucleus

8364:pld3
gene id: 8364:pld3
uniprot id: A0A6I8SF97
uniprot id: A0A8J1INB1
uniprot id: Q640B3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity).
messages: Belongs to the phospholipase D family.
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: It was initially thought that PDL3 has phospholipase D activity due to its HKD motifs. The second HKD motif contains Glu instead of the canonical Asp. Its enzyme activity is therefore unsure. Catalytic phospholipase D activity is still controversial (By similarity). Its closest homolog PLD4, exhibits no phospholipase activity (By similarity).
messages: Late endosome membrane
messages: Lysosome lumen
messages: N-glycosylated.
messages: Proteolytically processed to a soluble form that is stable within endosomes and lysosomes. During transport through the secretory pathway becomes proteolysed by cysteine proteases, thereby releasing a stable soluble lysosomal lumenal polypeptide, whereas the transmembrane-bound fragment is rapidly degraded. Its transport route to lysosomes involves ubiquitination and the ESCRT complex.
messages: Ubiquitinated. Ubiquitination mediates sorting into lysosomes.

8364:dnah14
gene id: 8364:dnah14
uniprot id: A0A8J1JMW8
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:LOC116408345
gene id: 8364:LOC116408345
uniprot id: A0A8J1J2P7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gmppa
gene id: 8364:gmppa
uniprot id: A0A5S6N5I2
uniprot id: Q0VFM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: GMPPA is a close homolog of GMPPB, that has been shown to catalyze the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. It has been hypothesized that GMPPA might serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. Alignment of GMPPAs and GMPPBs from various species shows that GMPPAs are characterized by a 2 amino acid-insertion (residues 11-12) in a highly conserved motif that borders the catalytic pocket and binds the nucleotide substrate in homologous enzymes. This insertion might inactivate the ancestral catalytic site, converting it to an allosteric site.
messages: May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.

8364:tmem167a
gene id: 8364:tmem167a
uniprot id: Q28FL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.

8364:dph1
gene id: 8364:dph1
uniprot id: A0A6I8RFC6
uniprot id: B5DE05
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

8364:inha
gene id: 8364:inha
uniprot id: Q4V787
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

8364:ube2a
gene id: 8364:ube2a
uniprot id: Q6GL05
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:senp7
gene id: 8364:senp7
uniprot id: A0A803J6Y1
uniprot id: A0A803JPW0
uniprot id: A0A803KAB0
uniprot id: A0A8J1J4Q4
names: Similarity
messages: Belongs to the peptidase C48 family.

8364:gphn
gene id: 8364:gphn
uniprot id: A0A6I8QSE6
uniprot id: A0A6I8RGW7
uniprot id: A0A6I8SN56
uniprot id: A0A8J0SVT1
uniprot id: A0A8J0SVT5
uniprot id: A0A8J0SVU5
uniprot id: A0A8J0T2S7
uniprot id: A0A8J0T2T7
uniprot id: A0A8J0T4W4
uniprot id: A0A8J0T4X4
uniprot id: A0A8J0T575
uniprot id: A0A8J0T583
uniprot id: A0A8J0T5Z3
uniprot id: A0A8J0T5Z8
uniprot id: A0A8J0T602
uniprot id: A0A8J1JXT1
uniprot id: A0A8J1JXT9
uniprot id: A4II88
uniprot id: F6TGB0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

8364:slc4a5
gene id: 8364:slc4a5
uniprot id: A0A6I8QMB7
uniprot id: A0A6I8T245
uniprot id: A0A8J1JB78
uniprot id: A0A8J1JB84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

8364:LOC108647661
gene id: 8364:LOC108647661
uniprot id: A0A8J1JL04
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:rpp30
gene id: 8364:rpp30
uniprot id: A0A8J1JV85
uniprot id: A0A8J1JWK3
uniprot id: F6T5A2
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

8364:trnt1
gene id: 8364:trnt1
uniprot id: A0A8J0SKT9
uniprot id: Q6P873
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

8364:trmo
gene id: 8364:trmo
uniprot id: A0A8J0T258
uniprot id: B0BLU9
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

8364:dcakd
gene id: 8364:dcakd
uniprot id: A4IH68
names: Similarity
messages: Belongs to the CoaE family.

8364:LOC100216027
gene id: 8364:LOC100216027
uniprot id: A0A803K9V7
uniprot id: B4F6H9
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8364:LOC105946414
gene id: 8364:LOC105946414
uniprot id: A0A8J1IZN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:brox
gene id: 8364:brox
uniprot id: A0A8J1JL11
uniprot id: A4IIL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BROX family.
messages: Membrane

8364:eif2s2
gene id: 8364:eif2s2
uniprot id: Q6P7N2
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

8364:inhbb
gene id: 8364:inhbb
uniprot id: A0A803JF31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

8364:hbz
gene id: 8364:hbz
uniprot id: A0A8J1IVT7
names: Similarity
messages: Belongs to the globin family.

8364:stam2
gene id: 8364:stam2
uniprot id: A0A6I8S2N2
uniprot id: F6PPK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Cell membrane
messages: Early endosome membrane
messages: Membrane

8364:elk1
gene id: 8364:elk1
uniprot id: A0A803JH85
uniprot id: A0A803JWU3
uniprot id: F7AXF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Nucleus

8364:ddb2
gene id: 8364:ddb2
uniprot id: Q66JG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Chromosome
messages: Component of the UV-DDB complex which includes ddb1 and ddb2 (By similarity). Component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that includes cul4a, or cul4b, ddb1, ddb2 and rbx1. A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces ddb2. These targeting subunits are generally known as DCAF (ddb1- and cul4-associated factor) or CDW (cul4-ddb1-associated WD40-repeat) proteins (By similarity).
messages: Interblade loops of the WD repeat region mediate most of the interaction with DNA. A hairpin between blades 5 and 6 inserts into DNA minor groove and mediates recognition of lesions and separation of the damaged and undamaged strands (By similarity).
messages: Nucleus
messages: Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair.
messages: The DWD box is required for interaction with ddb1.

8364:gpn3
gene id: 8364:gpn3
uniprot id: Q28I42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Heterodimer with gpn1. Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

8364:clmp
gene id: 8364:clmp
uniprot id: Q640U3
names: Subcellular Location Annotation
messages: Cell membrane
messages: tight junction

8364:bicd2l
gene id: 8364:bicd2l
uniprot id: A0A8J0T397
uniprot id: F7DDR5
names: Similarity
messages: Belongs to the BicD family.

8364:arhgef6
gene id: 8364:arhgef6
uniprot id: A0A6I8Q766
uniprot id: A0A6I8QWY3
uniprot id: A0A8J0SUG7
uniprot id: A0A8J1IPB5
names: Subcellular Location Annotation
messages: lamellipodium

8364:adgra2
gene id: 8364:adgra2
uniprot id: A0A6I8QSI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8364:il4i1
gene id: 8364:il4i1
uniprot id: A0A6I8Q8Z4
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

8364:uts2
gene id: 8364:uts2
uniprot id: A0A803JKK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

8364:ilkap
gene id: 8364:ilkap
uniprot id: A0A8J0SXH4
uniprot id: A0A8J0SY53
uniprot id: Q562D4
names: Similarity
messages: Belongs to the PP2C family.

8364:ptpn21
gene id: 8364:ptpn21
uniprot id: A0A6I8PWG5
uniprot id: A8WGH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

8364:prodh
gene id: 8364:prodh
uniprot id: A0A6I8SWR5
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

8364:LOC100489151
gene id: 8364:LOC100489151
uniprot id: A0A6I8PTB3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC100488021
gene id: 8364:LOC100488021
uniprot id: A0A6I8R705
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:fam3c
gene id: 8364:fam3c
uniprot id: A0A8J0SIK6
uniprot id: B0BLS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Involved in retinal laminar formation.
messages: Secreted

8364:kif20b
gene id: 8364:kif20b
uniprot id: A0A6I8Q781
uniprot id: A0A6I8QMR9
uniprot id: A0A6I8QN44
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:serpine3
gene id: 8364:serpine3
uniprot id: A0A8J1J510
names: Similarity
messages: Belongs to the serpin family.

8364:foxj3
gene id: 8364:foxj3
uniprot id: A0A8J0SPL7
uniprot id: A8E4V8
names: Subcellular Location Annotation
messages: Nucleus

8364:slc2a11.3
gene id: 8364:slc2a11.3
uniprot id: A0A8J0QHP2
uniprot id: A0A8J0QUZ4
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:LOC100493399
gene id: 8364:LOC100493399
uniprot id: A0A8J1JNZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:mogat2.2
gene id: 8364:mogat2.2
uniprot id: F7DA91
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:hmg20a
gene id: 8364:hmg20a
uniprot id: Q6DIJ5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in neuronal differentiation.

8364:hmgxb4
gene id: 8364:hmgxb4
uniprot id: Q5BL56
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with nlk.2.
messages: Negatively regulates Wnt/beta-catenin signaling during development.
messages: Nucleus

8364:hsf2.2
gene id: 8364:hsf2.2
uniprot id: A0A8J0SN18
uniprot id: L7MUI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8364:comt.2
gene id: 8364:comt.2
uniprot id: Q28HI0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.

8364:thrb
gene id: 8364:thrb
uniprot id: B3GR08
uniprot id: E7CYG2
uniprot id: E7CYG4
uniprot id: Q0EDH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:twsg1
gene id: 8364:twsg1
uniprot id: Q6DIM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

8364:tmem8b
gene id: 8364:tmem8b
uniprot id: A0A8J1IZ58
uniprot id: F6SHJ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:aldh16a1
gene id: 8364:aldh16a1
uniprot id: Q28CF4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:adat2
gene id: 8364:adat2
uniprot id: A0A8J1JKX1
uniprot id: Q0P4H0
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

8364:supt16h
gene id: 8364:supt16h
uniprot id: F7EL37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

8364:LOC100145155
gene id: 8364:LOC100145155
uniprot id: B0JZ58
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8364:pheta1
gene id: 8364:pheta1
uniprot id: A0A803KA04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

8364:LOC100496061
gene id: 8364:LOC100496061
uniprot id: F6UXP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

8364:tubd1
gene id: 8364:tubd1
uniprot id: Q6DIM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
messages: Belongs to the tubulin family.
messages: Cytoplasm
messages: Nucleus
messages: centriole
messages: cilium

8364:mospd3
gene id: 8364:mospd3
uniprot id: A0A8J1JAJ4
uniprot id: Q6DJ54
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

8364:c1qbp
gene id: 8364:c1qbp
uniprot id: F6T284
uniprot id: F7C800
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tnnt2
gene id: 8364:tnnt2
uniprot id: A0A8J0QLH7
uniprot id: A0A8J0R879
uniprot id: A0A8J0R8J1
uniprot id: A0A8J1J7P5
uniprot id: F7EHG0
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

8364:mgmt
gene id: 8364:mgmt
uniprot id: A0A803JLP7
uniprot id: F7AWA8
uniprot id: Q5M799
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

8364:rgs9bp
gene id: 8364:rgs9bp
uniprot id: F6ZEA4
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

8364:pdgfrl
gene id: 8364:pdgfrl
uniprot id: A0A803KIM3
uniprot id: F7E7S9
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Secreted

8364:cnot2
gene id: 8364:cnot2
uniprot id: A9JTQ3
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

8364:dscc1
gene id: 8364:dscc1
uniprot id: Q6GL75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DCC1 family.
messages: Component of the ctf18-RFC complex which consists of ctf18, ctf8, dscc1 and the RFC complex.
messages: Loads pcna onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion (By similarity).
messages: Nucleus

8364:isca2
gene id: 8364:isca2
uniprot id: A0A6I8PNK1
uniprot id: A0A8J0QUS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

8364:atmin
gene id: 8364:atmin
uniprot id: F6Q9X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

8364:LOC100486206
gene id: 8364:LOC100486206
uniprot id: F7CRR0
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

8364:LOC100485112
gene id: 8364:LOC100485112
uniprot id: A0A8J0QJM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:calca
gene id: 8364:calca
uniprot id: A0A803K560
uniprot id: A0A8J1JEE1
uniprot id: A0A8J1JHV9
names: Similarity
messages: Belongs to the calcitonin family.

8364:xpa
gene id: 8364:xpa
uniprot id: A0A803KI50
uniprot id: A0A8J0SKV3
uniprot id: F7AA61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

8364:LOC116406842
gene id: 8364:LOC116406842
uniprot id: A0A8J1IPZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC108646289
gene id: 8364:LOC108646289
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:mutyh
gene id: 8364:mutyh
uniprot id: Q0P4V1
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

8364:ewsr1
gene id: 8364:ewsr1
uniprot id: Q6DJQ4
uniprot id: Q6P3N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

8364:LOC100491805
gene id: 8364:LOC100491805
uniprot id: A0A6I8PZA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:tmem50a
gene id: 8364:tmem50a
uniprot id: A4QNG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

8364:LOC100494905
gene id: 8364:LOC100494905
uniprot id: A0A6I8PXP8
uniprot id: A0A803K2W7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

8364:atp6v1b2
gene id: 8364:atp6v1b2
uniprot id: Q0VGW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

8364:tfpi2
gene id: 8364:tfpi2
uniprot id: A0A803KIS5
uniprot id: F6RKG2
names: Subcellular Location Annotation
messages: Secreted

8364:cog6
gene id: 8364:cog6
uniprot id: Q6DJ24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

8364:dnaaf1
gene id: 8364:dnaaf1
uniprot id: A0A6I8QQ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: cilium

8364:LOC101732806
gene id: 8364:LOC101732806
uniprot id: A0A8J1JX27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

8364:aida
gene id: 8364:aida
uniprot id: A0A6I8R3F6
uniprot id: A0A8J0SDV4
uniprot id: F7E6Y8
uniprot id: Q6P821
names: Similarity
messages: Belongs to the AIDA family.

8364:or5f1l2.1
gene id: 8364:or5f1l2.1
uniprot id: A0A8J0QKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ttc26
gene id: 8364:ttc26
uniprot id: A0A6I8PVU2
uniprot id: A4III8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IFT56 family.
messages: Component of the IFT complex B.
messages: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Essential for maintaining proper microtubule organization within the ciliary axoneme.
messages: cilium

8364:crppa
gene id: 8364:crppa
uniprot id: A0A8J1JMY0
uniprot id: A0A8J1JQC5
uniprot id: Q28CZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (By similarity). Not involved in dolichol production (By similarity).
messages: Homodimer.
messages: cytosol

8364:tmprss2.14
gene id: 8364:tmprss2.14
uniprot id: A0A8J1J3H0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ubr1
gene id: 8364:ubr1
uniprot id: A0A7D9N0A0
uniprot id: A0A8J0SM06
uniprot id: A0A8J0SU58
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

8364:ventx2.1
gene id: 8364:ventx2.1
uniprot id: Q804C9
names: Subcellular Location Annotation
messages: Nucleus

8364:cpeb1
gene id: 8364:cpeb1
uniprot id: B4F6S8
uniprot id: F7B2S5
names: Similarity
messages: Belongs to the RRM CPEB family.

8364:rnasek
gene id: 8364:rnasek
uniprot id: F7DYQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Membrane

8364:f7
gene id: 8364:f7
uniprot id: Q0V9B6
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
messages: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:zfyve9
gene id: 8364:zfyve9
uniprot id: F6TE03
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

8364:pmp2
gene id: 8364:pmp2
uniprot id: A9UMU9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8364:l3hypdh
gene id: 8364:l3hypdh
uniprot id: Q66II5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the proline racemase family.
messages: Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C).
messages: Homodimer.
messages: In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 267 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.

8364:gpr162
gene id: 8364:gpr162
uniprot id: L7N2G3
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8364:sgf29
gene id: 8364:sgf29
uniprot id: B0BM70
names: Subcellular Location Annotation
messages: Nucleus

8364:foxi2
gene id: 8364:foxi2
uniprot id: B7ZTS3
uniprot id: Q28HT3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Possible transcriptional activator.

8364:rprd1a
gene id: 8364:rprd1a
uniprot id: F6PM62
names: Similarity
messages: Belongs to the UPF0400 (RTT103) family.

8364:capn8.1
gene id: 8364:capn8.1
uniprot id: A0A8J1JLX5
uniprot id: Q28C80
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:eci1
gene id: 8364:eci1
uniprot id: A0A8J1ISA7
uniprot id: F7CKL9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8364:taf1
gene id: 8364:taf1
uniprot id: A0A6I8QKD7
uniprot id: A0A8J0SVT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

8364:adrb1
gene id: 8364:adrb1
uniprot id: A0A8J0QM79
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC100497405
gene id: 8364:LOC100497405
uniprot id: A0A8J1ITB7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:cyp2a6.6
gene id: 8364:cyp2a6.6
uniprot id: A0A8J1IKX9
uniprot id: B2RYY6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:phpt1
gene id: 8364:phpt1
uniprot id: A0A803KJZ7
uniprot id: F7A7G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the janus family.
messages: Cytoplasm
messages: Exhibits phosphohistidine phosphatase activity.
messages: Monomer.

8364:slc35a2
gene id: 8364:slc35a2
uniprot id: A0A8J1IMQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

8364:tctex1d4
gene id: 8364:tctex1d4
uniprot id: A0A803JHX9
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8364:tnfsf15
gene id: 8364:tnfsf15
uniprot id: A0A803J3U1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8364:sin3b
gene id: 8364:sin3b
uniprot id: A0A8J0SQC0
uniprot id: Q0VA09
names: Subcellular Location Annotation
messages: Nucleus

8364:ndufa5
gene id: 8364:ndufa5
uniprot id: A0A6I8REN9
uniprot id: F6TDG6
uniprot id: Q28BN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Cytoplasm
messages: Mitochondrion inner membrane

8364:unc50
gene id: 8364:unc50
uniprot id: B5DEV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

8364:gucy2d
gene id: 8364:gucy2d
uniprot id: A0A8J0QZ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

8364:cops4
gene id: 8364:cops4
uniprot id: Q28J21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

8364:slc14a2
gene id: 8364:slc14a2
uniprot id: A0A803J7F5
uniprot id: A0A8J1IYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

8364:itgb7
gene id: 8364:itgb7
uniprot id: A0A6I8T0K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

8364:LOC116409619
gene id: 8364:LOC116409619
uniprot id: A0A8J1J8L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:slc27a4
gene id: 8364:slc27a4
uniprot id: A0A6I8S4U3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8364:dynlrb1
gene id: 8364:dynlrb1
uniprot id: A0A803KHJ5
uniprot id: A0A8J0SYI6
uniprot id: F6XUA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

8364:ubn1
gene id: 8364:ubn1
uniprot id: A0A803JG73
uniprot id: A0A8J0R7G2
uniprot id: A0A8J1ISW7
uniprot id: A0A8J1ISW9
names: Similarity
messages: Belongs to the ubinuclein family.

8364:ddx51
gene id: 8364:ddx51
uniprot id: A0A7D9NKV1
uniprot id: A0A8J0QZ88
names: Similarity
messages: Belongs to the DEAD box helicase family.

8364:ptger4
gene id: 8364:ptger4
uniprot id: B1WAT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

8364:LOC594886
gene id: 8364:LOC594886
uniprot id: A0A8J0QW80
uniprot id: F6VFJ1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:pik3cb
gene id: 8364:pik3cb
uniprot id: Q0IHS8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8364:idh3b
gene id: 8364:idh3b
uniprot id: A0A6I8SGT1
uniprot id: A0A8J0SC61
uniprot id: A0A8J1IXW8
uniprot id: A0A8J1IY49
uniprot id: B0BM21
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

8364:LOC100493330
gene id: 8364:LOC100493330
uniprot id: A0A6I8SF30
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8364:LOC100491286
gene id: 8364:LOC100491286
uniprot id: F7CL18
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:echdc2
gene id: 8364:echdc2
uniprot id: A9ULH7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8364:dync2h1
gene id: 8364:dync2h1
uniprot id: A0A6I8PXK3
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:f2r
gene id: 8364:f2r
uniprot id: A0A7D9NKE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:mmp17
gene id: 8364:mmp17
uniprot id: A0A803KK53
uniprot id: A4IIY9
names: Similarity
messages: Belongs to the peptidase M10A family.

8364:LOC100492943
gene id: 8364:LOC100492943
uniprot id: A0A6I8SRA4
uniprot id: A0A8J0SK05
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:slc47a2
gene id: 8364:slc47a2
uniprot id: A0A8J1JXU2
uniprot id: A0A8J1K0H7
uniprot id: A0A8J1K214
uniprot id: A4IIS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell membrane
messages: Membrane
messages: Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the secretion of cationic compounds including drugs, toxins and endogenous metabolites. Plays a role physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney and liver, into urine and bile respectively.

8364:cpne1
gene id: 8364:cpne1
uniprot id: A0A6I8T160
uniprot id: Q4VA76
names: Similarity
messages: Belongs to the copine family.

8364:slc7a13
gene id: 8364:slc7a13
uniprot id: A0A6I8SE79
names: Subcellular Location Annotation
messages: Membrane

8364:ptpn13
gene id: 8364:ptpn13
uniprot id: A0A6I8QDQ3
uniprot id: A0A6I8RFM9
uniprot id: A0A8J0S6G7
uniprot id: A0A8J0SAV3
uniprot id: A0A8J0SCP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
messages: cytoskeleton

8364:vps13a
gene id: 8364:vps13a
uniprot id: F6X0I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

8364:cyb5a
gene id: 8364:cyb5a
uniprot id: Q28EA4
names: Similarity
messages: Belongs to the cytochrome b5 family.

8364:LOC101733140
gene id: 8364:LOC101733140
uniprot id: F7CNA3
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:LOC100494404
gene id: 8364:LOC100494404
uniprot id: A0A8J0SVV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:slc9a4
gene id: 8364:slc9a4
uniprot id: A0A6I8PNM9
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

8364:tmc2
gene id: 8364:tmc2
uniprot id: A0A8J0QQC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8364:atg4b
gene id: 8364:atg4b
uniprot id: A0A8J0SNN6
uniprot id: A0A8J0STV3
uniprot id: Q0D2E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: autophagosome
messages: cytosol

8364:cdkl5
gene id: 8364:cdkl5
uniprot id: F6QJ00
names: Subcellular Location Annotation
messages: Lysosome
messages: Nucleus
messages: centrosome
messages: cytosol
messages: spindle

8364:chac1
gene id: 8364:chac1
uniprot id: A0A5S6P2T9
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

8364:uchl3
gene id: 8364:uchl3
uniprot id: A0A8J1J1Y5
uniprot id: Q28GY5
names: Similarity
messages: Belongs to the peptidase C12 family.

8364:LOC116407668
gene id: 8364:LOC116407668
uniprot id: A0A8J1IXQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:keap1
gene id: 8364:keap1
uniprot id: Q66JI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

8364:pithd1
gene id: 8364:pithd1
uniprot id: A0A8J0QJ57
uniprot id: A0A8J0R0D9
names: Similarity
messages: Belongs to the PITHD1 family.

8364:agrn
gene id: 8364:agrn
uniprot id: A0A6I8RCQ3
uniprot id: A0A8J0SJD3
uniprot id: A0A8J0SU28
uniprot id: A0A8J0SVQ1
uniprot id: A0A8J0T2N7
uniprot id: A0A8J0T4T0
uniprot id: A0A8J0T5W1
uniprot id: F6RJS6
names: Caution
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:slc39a8
gene id: 8364:slc39a8
uniprot id: F6T0H5
names: Subcellular Location Annotation
messages: Membrane

8364:dpt
gene id: 8364:dpt
uniprot id: A0A803KHE8
uniprot id: F6TII7
names: Similarity
messages: Belongs to the dermatopontin family.

8364:map4k1
gene id: 8364:map4k1
uniprot id: A0A8J1IQI5
uniprot id: A0A8J1ISY1
uniprot id: F7DD19
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

8364:LOC100493251
gene id: 8364:LOC100493251
uniprot id: A0A8J0T0X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

8364:abhd16a
gene id: 8364:abhd16a
uniprot id: F7CRT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

8364:gna11
gene id: 8364:gna11
uniprot id: Q6P7M2
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

8364:MGC108450
gene id: 8364:MGC108450
uniprot id: A0A803KI89
uniprot id: F7DBX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:lyrm2
gene id: 8364:lyrm2
uniprot id: B3DLF3
names: Similarity
messages: Belongs to the complex I LYR family.

8364:atp6ap1l
gene id: 8364:atp6ap1l
uniprot id: A0A6I8PRK7
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

8364:nkx2-1
gene id: 8364:nkx2-1
uniprot id: A0A6I8RFC3
names: Subcellular Location Annotation
messages: Nucleus

8364:eif3j
gene id: 8364:eif3j
uniprot id: A0A8J0QGZ9
uniprot id: Q5I0B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8364:ankrd9
gene id: 8364:ankrd9
uniprot id: F6ZER5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

8364:LOC100493554
gene id: 8364:LOC100493554
uniprot id: A0A8J1JWW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tspan18
gene id: 8364:tspan18
uniprot id: F7BFP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:ap1s1
gene id: 8364:ap1s1
uniprot id: A0A6I8RBY5
uniprot id: Q6P2W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

8364:tfeb
gene id: 8364:tfeb
uniprot id: A0A8J1J5S8
uniprot id: Q08D59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

8364:pcyt1a
gene id: 8364:pcyt1a
uniprot id: A0A8J1JNG7
uniprot id: F7DAV8
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

8364:gbp4
gene id: 8364:gbp4
uniprot id: Q5BKG3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:vps25
gene id: 8364:vps25
uniprot id: F6T240
names: Similarity
messages: Belongs to the VPS25 family.

8364:anxa1.1
gene id: 8364:anxa1.1
uniprot id: Q6P2X5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium

8364:ddx55
gene id: 8364:ddx55
uniprot id: A0A8J1IZV9
uniprot id: B1H117
names: Similarity
messages: Belongs to the DEAD box helicase family.

8364:arhgap32
gene id: 8364:arhgap32
uniprot id: A0A6I8PZJ5
uniprot id: A0A6I8QDM5
uniprot id: A0A6I8QN72
uniprot id: A0A6I8RZ78
uniprot id: A0A8J0R548
uniprot id: A0A8J0R5Q7
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

8364:bcl2
gene id: 8364:bcl2
uniprot id: A0A6I8QYM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

8364:LOC100497341
gene id: 8364:LOC100497341
uniprot id: A0A803K0H1
names: Similarity
messages: Belongs to the cyclin family.

8364:lyl1
gene id: 8364:lyl1
uniprot id: F7B9G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:LOC105945923
gene id: 8364:LOC105945923
uniprot id: A0A8J1JX19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:t2r45
gene id: 8364:t2r45
uniprot id: Q2AB42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:LOC100487361
gene id: 8364:LOC100487361
uniprot id: A0A8J1J2G5
names: Similarity
messages: Belongs to the ferlin family.

8364:LOC116406519
gene id: 8364:LOC116406519
uniprot id: A0A8J1INH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.
messages: Nucleus

8364:tmem88
gene id: 8364:tmem88
uniprot id: A0A6I8QCZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

8364:crcp
gene id: 8364:crcp
uniprot id: A0A803KCW2
uniprot id: A0A8J0T0R7
uniprot id: A0A8J1J593
uniprot id: Q28HG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

8364:get3
gene id: 8364:get3
uniprot id: Q0IIZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1/WRB, CAMLG/GET2 and GET3/TRC40. Within the complex, CAMLG and GET1 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.

8364:myd88
gene id: 8364:myd88
uniprot id: A0A8F2WAP5
uniprot id: Q28DJ2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
messages: Cytoplasm
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.

8364:shisal2b
gene id: 8364:shisal2b
uniprot id: F6RSR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dad1
gene id: 8364:dad1
uniprot id: Q28FI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

8364:p2rx5
gene id: 8364:p2rx5
uniprot id: A0A6I8SK99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8364:asph
gene id: 8364:asph
uniprot id: A0A6I8QPT2
uniprot id: A0A6I8RBX0
uniprot id: A0A6I8S9H0
uniprot id: A0A6I8S9Q9
uniprot id: A0A803JM89
uniprot id: A0A8J0PG59
uniprot id: A0A8J1JMV3
uniprot id: A0A8J1JMV7
uniprot id: A0A8J1JMW1
uniprot id: A0A8J1JMW2
uniprot id: A0A8J1JMW3
uniprot id: A0A8J1JQA1
uniprot id: A0A8J1JQA7
uniprot id: A0A8J1JRJ8
uniprot id: A0A8J1JRK8
uniprot id: A0A8J1JRL5
uniprot id: F6RBK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane

8364:septin11
gene id: 8364:septin11
uniprot id: A0A6I8Q7Y6
uniprot id: A0A8J1J640
uniprot id: A0A8J1J643
uniprot id: A0A8J1J8I5
uniprot id: A0A8J1J9I9
uniprot id: A0A8J1J9J4
uniprot id: B1H3L0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8364:golm1
gene id: 8364:golm1
uniprot id: A0A8J0QGW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

8364:zfpl1
gene id: 8364:zfpl1
uniprot id: Q0VFM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZFPL1 family.
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: cis-Golgi network membrane

8364:chaf1b
gene id: 8364:chaf1b
uniprot id: A0A8J0QTT6
uniprot id: F6QPI7
names: Subcellular Location Annotation
messages: Nucleus

8364:KEG17 p13
gene id: 8364:KEG17_p13
uniprot id: Q5G7J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Membrane
messages: Mitochondrion inner membrane

8364:cdk17
gene id: 8364:cdk17
uniprot id: A0A8J0SHF5
uniprot id: F6Z6S8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:usp33
gene id: 8364:usp33
uniprot id: Q28CN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of ccp110 in S and G2/M phase, leading to stabilize ccp110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of robo1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of robo1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (arrb1 and arrb2) and beta-2 adrenergic receptor (adrb2). Deubiquitinates dio2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity).
messages: centrosome
messages: perinuclear region

8364:minar2
gene id: 8364:minar2
uniprot id: A0A6I8Q300
names: Similarity
messages: Belongs to the MINAR family.

8364:LOC100491442
gene id: 8364:LOC100491442
uniprot id: A0A8J0QJ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8364:cmtm8
gene id: 8364:cmtm8
uniprot id: A0A803JT43
uniprot id: A0A8J1JTV2
names: Subcellular Location Annotation
messages: Membrane

8364:cxxc4
gene id: 8364:cxxc4
uniprot id: A0A803KBE6
uniprot id: A0A8J0SRD8
uniprot id: Q0VFP6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Acts as a negative regulator of the Wnt signaling pathway required for anterior neural structure formation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).
messages: Cytoplasm
messages: The CXXC zinc finger mediates binding to CpG-DNA.

8364:LOC100489446
gene id: 8364:LOC100489446
uniprot id: A0A8J0QYQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dmrt3
gene id: 8364:dmrt3
uniprot id: R4HHX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

8364:fam126a
gene id: 8364:fam126a
uniprot id: A0A803KKU5
uniprot id: A0A8J0SGN8
uniprot id: A0A8J1JN74
uniprot id: F7EHL4
uniprot id: F7EHM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

8364:rpl10a
gene id: 8364:rpl10a
uniprot id: A0A6I8QWL3
uniprot id: A0A8J0SCU2
uniprot id: A0A8J0SDM6
uniprot id: B0BM93
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

8364:rpl10
gene id: 8364:rpl10
uniprot id: Q6DIQ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

8364:fxyd2
gene id: 8364:fxyd2
uniprot id: B1H356
names: Similarity
messages: Belongs to the FXYD family.

8364:ddx27
gene id: 8364:ddx27
uniprot id: A0A8J0SBQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:LOC100493529
gene id: 8364:LOC100493529
uniprot id: A0A8J0R089
uniprot id: F7EGU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

8364:gal3st4.5
gene id: 8364:gal3st4.5
uniprot id: A0A8J1JBY6
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

8364:cops7b
gene id: 8364:cops7b
uniprot id: F7ED99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

8364:LOC100498470
gene id: 8364:LOC100498470
uniprot id: A0A8J1JR72
names: Subcellular Location Annotation
messages: Nucleus

8364:tf
gene id: 8364:tf
uniprot id: Q501K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Plasma.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation (By similarity).

8364:lmf1
gene id: 8364:lmf1
uniprot id: A0A6I8RDR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

8364:aco2
gene id: 8364:aco2
uniprot id: Q5I0B1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

8364:mogat2.1
gene id: 8364:mogat2.1
uniprot id: Q5M8H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA.
messages: Endoplasmic reticulum membrane
messages: perinuclear region

8364:coro1a
gene id: 8364:coro1a
uniprot id: A0A8J1IVE5
uniprot id: Q6DJ14
names: Similarity
messages: Belongs to the WD repeat coronin family.

8364:nodal2
gene id: 8364:nodal2
uniprot id: A0A6I8SKM0
names: Similarity
messages: Belongs to the TGF-beta family.

8364:coa8
gene id: 8364:coa8
uniprot id: A0A8J0R6N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

8364:mast2
gene id: 8364:mast2
uniprot id: A0A6I8Q836
uniprot id: A0A6I8RGT2
uniprot id: A0A8J1JDT6
uniprot id: A0A8J1JDU4
uniprot id: A0A8J1JGB1
uniprot id: A0A8J1JHB7
uniprot id: B3DLH8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

8364:kcnq2
gene id: 8364:kcnq2
uniprot id: A0A6I8SIM6
uniprot id: A0A803JMV6
uniprot id: A0A803K497
uniprot id: A0A8J1IY01
uniprot id: A0A8J1J182
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:romo1
gene id: 8364:romo1
uniprot id: A4QNF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity).
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity).
messages: Mitochondrion inner membrane

8364:dlx4
gene id: 8364:dlx4
uniprot id: A0A6I8QM52
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116409632
gene id: 8364:LOC116409632
uniprot id: A0A8J1JC46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:rtcb
gene id: 8364:rtcb
uniprot id: Q561P3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
messages: Nucleus

8364:LOC108648817
gene id: 8364:LOC108648817
uniprot id: A0A8J1IZ20
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:fgfr3
gene id: 8364:fgfr3
uniprot id: A0A6I8RGZ1
uniprot id: A0A6I8SPF3
uniprot id: A0A8J0SG86
uniprot id: A0A8J1J4S6
uniprot id: B4F6W5
uniprot id: F6V1T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:LOC100135384
gene id: 8364:LOC100135384
uniprot id: A9UMK7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:LOC100490207
gene id: 8364:LOC100490207
uniprot id: A0A8J0QW92
uniprot id: A0A8J0T3F8
uniprot id: A0A8J1JPL6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101735014
gene id: 8364:LOC101735014
uniprot id: A0A8J1JRP3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100498358
gene id: 8364:LOC100498358
uniprot id: A0A6I8PYI9
names: Similarity
messages: Belongs to the TCAF family.

8364:LOC100216037
gene id: 8364:LOC100216037
uniprot id: A0A8J0SZZ1
uniprot id: B4F6J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

8364:cryaa
gene id: 8364:cryaa
uniprot id: F7DB35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm

8364:myof.1
gene id: 8364:myof.1
uniprot id: A0A6I8QNL3
uniprot id: A0A6I8S9W7
uniprot id: A0A7D9NM49
uniprot id: A0A8J0SHI0
uniprot id: A0A8J1JRL8
uniprot id: A0A8J1JRN2
uniprot id: A0A8J1JU27
uniprot id: A0A8J1JVD0
uniprot id: B3DLH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: May play a role in membrane regeneration and repair.
messages: Membrane
messages: Nucleus membrane

8364:twsg2
gene id: 8364:twsg2
uniprot id: F6TDS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

8364:b3gat2
gene id: 8364:b3gat2
uniprot id: Q599J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:ca4.2
gene id: 8364:ca4.2
uniprot id: A0A6I8QID1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

8364:cd93
gene id: 8364:cd93
uniprot id: A0A8J0QT25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ptafr
gene id: 8364:ptafr
uniprot id: F6WY76
uniprot id: Q66JK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

8364:cln3
gene id: 8364:cln3
uniprot id: A0A8J0QU72
uniprot id: A0A8J0R4E5
uniprot id: A0A8J1IUC1
uniprot id: F7CYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

8364:il28b.1
gene id: 8364:il28b.1
uniprot id: D2DJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

8364:LOC105948062
gene id: 8364:LOC105948062
uniprot id: A0A803JY47
names: Similarity
messages: Belongs to the cyclin family.

8364:akap9
gene id: 8364:akap9
uniprot id: A0A6I8QMJ9
uniprot id: A0A6I8RZ42
uniprot id: A0A6I8SMY0
uniprot id: A0A8J0SPB5
uniprot id: A0A8J1JV87
names: Subcellular Location Annotation
messages: centrosome

8364:pla2g4f
gene id: 8364:pla2g4f
uniprot id: F6TFZ5
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

8364:LOC100492058
gene id: 8364:LOC100492058
uniprot id: A0A6I8T149
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:mrpl3
gene id: 8364:mrpl3
uniprot id: Q28I48
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

8364:gnpnat1
gene id: 8364:gnpnat1
uniprot id: A0A803KIV8
uniprot id: F6W955
uniprot id: Q6DJC3
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

8364:inppl1
gene id: 8364:inppl1
uniprot id: A0A803J7U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane
messages: Nucleus speckle
messages: filopodium
messages: lamellipodium

8364:stx3
gene id: 8364:stx3
uniprot id: A0A6I8Q9V6
uniprot id: A0A6I8RSM5
uniprot id: A0A8J1JSQ0
uniprot id: A0A8J1JSQ1
uniprot id: A0A8J1JV75
uniprot id: Q28FZ2
names: Similarity
messages: Belongs to the syntaxin family.

8364:LOC100492749
gene id: 8364:LOC100492749
uniprot id: A0A8J0SC43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:atp5pd
gene id: 8364:atp5pd
uniprot id: F6W0P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

8364:rhbdf2
gene id: 8364:rhbdf2
uniprot id: A0JPA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

8364:man2b1
gene id: 8364:man2b1
uniprot id: Q0P4W0
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

8364:dnase2b
gene id: 8364:dnase2b
uniprot id: A0A8J1JDF0
uniprot id: F6RG98
names: Similarity
messages: Belongs to the DNase II family.

8364:ins
gene id: 8364:ins
uniprot id: A0A803KJL1
uniprot id: F6QRS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

8364:serp1
gene id: 8364:serp1
uniprot id: Q6P650
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

8364:recql
gene id: 8364:recql
uniprot id: A0A6I8SNZ1
uniprot id: Q28GA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

8364:mphosph10
gene id: 8364:mphosph10
uniprot id: F7DW06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

8364:pgk1
gene id: 8364:pgk1
uniprot id: A0A8J0PI02
uniprot id: A0A8J0SVK3
uniprot id: F6WY38
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

8364:selenom
gene id: 8364:selenom
uniprot id: A0A8J0QDF7
names: Similarity
messages: Belongs to the selenoprotein M/F family.

8364:trim3
gene id: 8364:trim3
uniprot id: F6TSI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

8364:LOC100486876
gene id: 8364:LOC100486876
uniprot id: A0A803JWC9
uniprot id: A0A8J0QL45
uniprot id: A0A8J0R8M5
uniprot id: F6W2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

8364:adamts16
gene id: 8364:adamts16
uniprot id: A0A6I8T1W7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:LOC105946962
gene id: 8364:LOC105946962
uniprot id: A0A8J1J8F0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:naf1
gene id: 8364:naf1
uniprot id: A0A6I8SUY2
uniprot id: A0A8J1J2R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

8364:ankrd13c
gene id: 8364:ankrd13c
uniprot id: Q28C34
names: Function
names: Subcellular Location Annotation
messages: Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
messages: Endoplasmic reticulum membrane

8364:LOC100490752
gene id: 8364:LOC100490752
uniprot id: A0A6I8Q093
uniprot id: A0A803JU71
uniprot id: A0A8J0R2C4
uniprot id: A0A8J1JB33
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

8364:egr3
gene id: 8364:egr3
uniprot id: A0A6I8PUI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

8364:LOC100496657
gene id: 8364:LOC100496657
uniprot id: A0A8J0R0S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:gng12
gene id: 8364:gng12
uniprot id: A4QNP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:LOC100497803
gene id: 8364:LOC100497803
uniprot id: A0A8J0QUG2
uniprot id: A0A8J0SC47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mecr
gene id: 8364:mecr
uniprot id: Q28GQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro (By similarity). Functions in pronephros development, regulating late differentiation of all pronephric tubule segments (PubMed:18472403).
messages: Expressed in the developing pronephros.
messages: Homodimer.
messages: Mitochondrion

8364:tmem132b
gene id: 8364:tmem132b
uniprot id: A0A6I8Q0N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

8364:scrn2
gene id: 8364:scrn2
uniprot id: A0A8J0S9H4
uniprot id: F6QJA0
uniprot id: Q0V984
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

8364:mul1
gene id: 8364:mul1
uniprot id: A0A8J1JY41
names: Subcellular Location Annotation
messages: Membrane

8364:cables2
gene id: 8364:cables2
uniprot id: A0A803KDU1
uniprot id: A0A803KI25
uniprot id: F6PJ45
names: Similarity
messages: Belongs to the cyclin family.

8364:LOC100170420
gene id: 8364:LOC100170420
uniprot id: F6ZMN7
names: Similarity
messages: Belongs to the thioredoxin family.

8364:epb42
gene id: 8364:epb42
uniprot id: A0A8J0QR42
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

8364:rnf145
gene id: 8364:rnf145
uniprot id: Q0IJ20
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100498329
gene id: 8364:LOC100498329
uniprot id: A0A6I8QAK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:rapgef6
gene id: 8364:rapgef6
uniprot id: A0A6I8QAH6
uniprot id: A0A6I8R0N6
uniprot id: A0A6I8S7M4
uniprot id: A0A8J0SS41
uniprot id: A0A8J0T137
uniprot id: A0A8J0T2C1
uniprot id: A0A8J0T2C6
uniprot id: F7E820
uniprot id: F7E827
names: Similarity
messages: Belongs to the RAPGEF2 family.

8364:scap
gene id: 8364:scap
uniprot id: B0JZG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

8364:LOC101734494
gene id: 8364:LOC101734494
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:zbtb8os
gene id: 8364:zbtb8os
uniprot id: A0A8J0PIH9
uniprot id: A0A8J0S7P8
uniprot id: F6ZCC9
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

8364:amz2
gene id: 8364:amz2
uniprot id: A0A8J1IWU6
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

8364:pkp3
gene id: 8364:pkp3
uniprot id: F7B720
names: Similarity
messages: Belongs to the beta-catenin family.

8364:LOC100216007
gene id: 8364:LOC100216007
uniprot id: B0JZZ3
names: Similarity
messages: Belongs to the globin family.

8364:dennd5a
gene id: 8364:dennd5a
uniprot id: A0A6I8RLZ6
uniprot id: A0A6I8S920
uniprot id: B2GUD7
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC105945589
gene id: 8364:LOC105945589
uniprot id: A0A8J0T573
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tmprss2.7
gene id: 8364:tmprss2.7
uniprot id: A0A8J1J3G5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nap1l4
gene id: 8364:nap1l4
uniprot id: A0A803J6S5
uniprot id: Q0IHT8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

8364:LOC100491749
gene id: 8364:LOC100491749
uniprot id: A0A803JP14
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8364:gdf5
gene id: 8364:gdf5
uniprot id: B5BNX6
names: Similarity
messages: Belongs to the TGF-beta family.

8364:lig3
gene id: 8364:lig3
uniprot id: B4F6N5
uniprot id: F6WXI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

8364:atp5me
gene id: 8364:atp5me
uniprot id: B3DLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

8364:timm50
gene id: 8364:timm50
uniprot id: B0BMA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

8364:LOC116410852
gene id: 8364:LOC116410852
uniprot id: A0A8J1JJ72
uniprot id: A0A8J1JJ76
uniprot id: A0A8J1JJ80
uniprot id: A0A8J1JLN0
names: Subcellular Location Annotation
messages: Membrane

8364:gpha2
gene id: 8364:gpha2
uniprot id: A0A6I8QD90
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer of an alpha and a beta chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:sh3bp4
gene id: 8364:sh3bp4
uniprot id: Q5U228
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer or homooligomer.
messages: Nucleus
messages: Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).
messages: The SH3 domain mediates localization to the clathrin-coated pits and vesicles.
messages: clathrin-coated pit
messages: clathrin-coated vesicle

8364:myo15a
gene id: 8364:myo15a
uniprot id: A0A8J1IUU9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:clca4.1
gene id: 8364:clca4.1
uniprot id: A0A8J0SLL7
names: Similarity
messages: Belongs to the CLCR family.

8364:krt12.2
gene id: 8364:krt12.2
uniprot id: A0A1B8Y9F0
names: Similarity
messages: Belongs to the intermediate filament family.

8364:arl3
gene id: 8364:arl3
uniprot id: A0A8J0QV90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

8364:sh2d4a
gene id: 8364:sh2d4a
uniprot id: Q08CX2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits estrogen-induced cell proliferation.

8364:mrpl46
gene id: 8364:mrpl46
uniprot id: A4QNB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

8364:piezo1
gene id: 8364:piezo1
uniprot id: A0A6I8Q0I3
uniprot id: A0A8J0SK06
uniprot id: F6SPB7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIEZO (TC 1.A.75) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:rft1
gene id: 8364:rft1
uniprot id: A0A8J0ST32
uniprot id: Q0D2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane (By similarity).
messages: Membrane

8364:LOC101733971
gene id: 8364:LOC101733971
uniprot id: A0A1B8XVM9
names: Similarity
messages: Belongs to the cyclin family.

8364:ttr
gene id: 8364:ttr
uniprot id: A4QNN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with rbp4 (By similarity).
messages: Secreted
messages: The N-terminus strongly influences thyroid hormone-binding properties.
messages: Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4). Probably transports triiodothyronine from the bloodstream to the brain (By similarity).

8364:ret
gene id: 8364:ret
uniprot id: A0A6I8R222
uniprot id: A0A8J0SJ51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

8364:atp10a
gene id: 8364:atp10a
uniprot id: A0A6I8QGU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:tmem19
gene id: 8364:tmem19
uniprot id: A0A8J1J9T4
uniprot id: Q0P4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

8364:pga4
gene id: 8364:pga4
uniprot id: F6ZBR1
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:gsg1
gene id: 8364:gsg1
uniprot id: A0A6I8SE27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

8364:slc1a5
gene id: 8364:slc1a5
uniprot id: F7C3I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8364:gna13
gene id: 8364:gna13
uniprot id: B1H2U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

8364:LOC100485649
gene id: 8364:LOC100485649
uniprot id: A0A1B8Y8U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:nt5dc4
gene id: 8364:nt5dc4
uniprot id: A0A6I8QVF4
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

8364:tonsl
gene id: 8364:tonsl
uniprot id: A0A803JI00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

8364:grin2a
gene id: 8364:grin2a
uniprot id: F6X9P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

8364:abraxas2
gene id: 8364:abraxas2
uniprot id: Q6P4W0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although strongly related to the abraxas1 protein, lacks the C-terminal pSXXF that constitutes a specific recognition motif for the BRCT domain of brca1.
messages: Belongs to the FAM175 family. Abro1 subfamily.
messages: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1 (By similarity).
messages: Component of the BRISC complex, at least composed of ABRAXAS2 and the catalytic subunit brcc3/brcc36. Interacts with brcc3/brcc36; the interaction is direct. The BRISC complex binds monoubiquitin and polyubiquitin.
messages: Cytoplasm
messages: Nucleus
messages: cytoskeleton
messages: spindle pole

8364:slc2a1
gene id: 8364:slc2a1
uniprot id: Q0P4X7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:gpam
gene id: 8364:gpam
uniprot id: A0A803JYP3
uniprot id: Q05B36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

8364:slc27a6
gene id: 8364:slc27a6
uniprot id: Q28E33
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8364:plk4
gene id: 8364:plk4
uniprot id: A0A8J0SFJ5
uniprot id: B3DL84
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Homodimer.
messages: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity).
messages: Ubiquitinated; leading to its degradation by the proteasome.
messages: centriole
messages: centrosome

8364:riox2
gene id: 8364:riox2
uniprot id: A0A8J0R125
uniprot id: F6QTR9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. MINA53 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
messages: nucleolus

8364:rgs9bpl
gene id: 8364:rgs9bpl
uniprot id: Q5M8K0
names: Function
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.
messages: Regulator of G protein-coupled receptor (GPCR) signaling. Probably acts by regulating the activity of some 'R7' family protein (RGS6, RGS7, RGS9 and/or RGS11).

8364:ago4
gene id: 8364:ago4
uniprot id: A0A6I8QIJ1
uniprot id: A0A6I8QUP2
uniprot id: A0A8J0QQ99
uniprot id: A0A8J0QW37
uniprot id: A0A8J0R0B9
uniprot id: A0A8J0S855
uniprot id: A0A8J0SDD8
uniprot id: A0A8J0SGB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Ago subfamily.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

8364:ca6
gene id: 8364:ca6
uniprot id: Q0P4T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide. Its role in saliva is unknown.
messages: Secreted

8364:shkbp1
gene id: 8364:shkbp1
uniprot id: A0A6I8QM61
uniprot id: A0A6I8SXB4
uniprot id: A0A8J0SWM6
names: Similarity
messages: Belongs to the KCTD3 family.

8364:gsto2
gene id: 8364:gsto2
uniprot id: Q6DET4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

8364:wdr92
gene id: 8364:wdr92
uniprot id: A4QNE6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Dynein axonemal particle
messages: Interacts with PIH1D1; the interaction associates DNAAF10 with the R2TP complex (By similarity). Interacts with several dynein axonemal assembly factors (By similarity).
messages: Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.

8364:chst8
gene id: 8364:chst8
uniprot id: A0A6I8SXI5
uniprot id: A0A8J0ST28
uniprot id: Q0D2D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:lrwd1
gene id: 8364:lrwd1
uniprot id: B0JZ65
uniprot id: F6V4R8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRWD1 family.
messages: Component of the ORC complex.
messages: Nucleus
messages: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity).
messages: The entire WD repeat region is required for the interaction with ORC complex components, as well as for association with chromatin and for binding to histone methylation marks.
messages: centromere
messages: centrosome
messages: kinetochore
messages: telomere

8364:polr3gl
gene id: 8364:polr3gl
uniprot id: A8E5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

8364:crisp1.3
gene id: 8364:crisp1.3
uniprot id: Q642T6
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116411038
gene id: 8364:LOC116411038
uniprot id: A0A8J1JNQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ggt6
gene id: 8364:ggt6
uniprot id: A0A8J1IZ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

8364:ca12
gene id: 8364:ca12
uniprot id: A4IGN0
uniprot id: Q28H50
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:polr2g
gene id: 8364:polr2g
uniprot id: Q28G24
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

8364:pou2f3
gene id: 8364:pou2f3
uniprot id: A0A8J1JWA7
uniprot id: A0A8J1JWB5
uniprot id: A0A8J1K0D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

8364:LOC101733959
gene id: 8364:LOC101733959
uniprot id: A0A8J1JE10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:lig1
gene id: 8364:lig1
uniprot id: A0A8J0QYK6
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

8364:atrx
gene id: 8364:atrx
uniprot id: A0A6I8SPZ1
uniprot id: A0A8J0R5A0
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

8364:tubb1
gene id: 8364:tubb1
uniprot id: A0A803JKJ4
uniprot id: A0A8J1IY90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8364:fam135b
gene id: 8364:fam135b
uniprot id: A0A8J0T563
names: Similarity
messages: Belongs to the FAM135 family.

8364:psmb3
gene id: 8364:psmb3
uniprot id: A9ULB6
uniprot id: Q28HP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8364:hhipl1
gene id: 8364:hhipl1
uniprot id: A0A6I8PNF8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:apmap
gene id: 8364:apmap
uniprot id: A0A6I8RQS8
names: Similarity
messages: Belongs to the strictosidine synthase family.

8364:cd248
gene id: 8364:cd248
uniprot id: A0A803KD80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tub
gene id: 8364:tub
uniprot id: A0A8J1JDB4
uniprot id: Q68FB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

8364:mat2a
gene id: 8364:mat2a
uniprot id: Q6P1T2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

8364:adra2a
gene id: 8364:adra2a
uniprot id: Q0P4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:prnp
gene id: 8364:prnp
uniprot id: A0A8J0SSQ4
uniprot id: A2BDH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prion family.
messages: Cell membrane
messages: Membrane

8364:amdhd2
gene id: 8364:amdhd2
uniprot id: B1H1C0
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

8364:LOC100493994
gene id: 8364:LOC100493994
uniprot id: A0A8J0R0E2
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:p2ry14
gene id: 8364:p2ry14
uniprot id: A0A803K3W5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:bsg
gene id: 8364:bsg
uniprot id: A0A6I8PVU9
uniprot id: A1L0Z2
uniprot id: F7AVC6
uniprot id: Q28IV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the group II decarboxylase family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lateral cell membrane

8364:nme4
gene id: 8364:nme4
uniprot id: A0A8J0SY75
uniprot id: Q28BM9
names: Similarity
messages: Belongs to the NDK family.

8364:LOC116410894
gene id: 8364:LOC116410894
uniprot id: A0A8J1JKB1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:abcg2
gene id: 8364:abcg2
uniprot id: A0A6I8PZY2
uniprot id: Q28BS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

8364:prkcb
gene id: 8364:prkcb
uniprot id: A0A6I8SS53
uniprot id: A8KBH6
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by diacylglycerol which in turn phosphorylates a range of cellular proteins.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates isoform p66Shc of shc1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (andr)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation (By similarity).
messages: Cytoplasm
messages: Membrane
messages: Nucleus
messages: Phosphorylation on Thr-497 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-638 maintains catalytic competence, and autophosphorylation on Ser-657 appears to release the kinase into the cytosol (By similarity).

8364:nip7
gene id: 8364:nip7
uniprot id: A4QND5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity).
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

8364:LOC108645245
gene id: 8364:LOC108645245
uniprot id: A0A8J1IUC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus

8364:LOC105946314
gene id: 8364:LOC105946314
uniprot id: A0A8J1J2J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rps19bp1
gene id: 8364:rps19bp1
uniprot id: Q28IC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: Direct regulator of SIRT1.
messages: nucleolus

8364:LOC116409575
gene id: 8364:LOC116409575
uniprot id: A0A8J1J8E2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:anp32c
gene id: 8364:anp32c
uniprot id: A0A8J0T235
uniprot id: Q6P1U7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANP32 family.
messages: Histone binding is mediated by the concave surface of the LRR region.
messages: Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome (By similarity).
messages: Nucleus

8364:begain
gene id: 8364:begain
uniprot id: A0A6I8QD04
uniprot id: A0A8J0Q8S3
uniprot id: A0A8J0STW0
uniprot id: A0A8J0SUQ7
uniprot id: A0A8J0T2U3
uniprot id: A8WGG1
names: Subcellular Location Annotation
messages: Membrane

8364:lactb2
gene id: 8364:lactb2
uniprot id: A0A8J1JN59
uniprot id: Q0V9A9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.
messages: Mitochondrion matrix

8364:acox1
gene id: 8364:acox1
uniprot id: F6UF69
uniprot id: Q5EBF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

8364:LOC100135138
gene id: 8364:LOC100135138
uniprot id: A9JSD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

8364:srpx
gene id: 8364:srpx
uniprot id: A0A6I8QHP4
uniprot id: F7B286
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:slc4a9
gene id: 8364:slc4a9
uniprot id: A0A6I8RCR7
uniprot id: A0A8J0SGP4
uniprot id: A0A8J0SJL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC100492335
gene id: 8364:LOC100492335
uniprot id: A0A8J0QTV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116408613
gene id: 8364:LOC116408613
uniprot id: A0A8J1J530
names: Subcellular Location Annotation
messages: Membrane

8364:ankrd37
gene id: 8364:ankrd37
uniprot id: Q28FJ2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:mycn
gene id: 8364:mycn
uniprot id: Q6DEU8
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8364:rgmb
gene id: 8364:rgmb
uniprot id: Q6P8A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8364:mus81
gene id: 8364:mus81
uniprot id: A0A6I8R1Y3
uniprot id: A0A8J0SLA2
uniprot id: A0A8J0T2G0
uniprot id: A0A8J1JDE7
uniprot id: Q640B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Binds eme1.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity).
messages: Nucleus

8364:slc1a7
gene id: 8364:slc1a7
uniprot id: A0A6I8RPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8364:LOC100495739
gene id: 8364:LOC100495739
uniprot id: B5DDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:tp53
gene id: 8364:tp53
uniprot id: Q6NTF1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Nucleus

8364:dlat
gene id: 8364:dlat
uniprot id: B1H2L3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

8364:cpne5
gene id: 8364:cpne5
uniprot id: A4IIK4
names: Similarity
messages: Belongs to the copine family.

8364:hspa14
gene id: 8364:hspa14
uniprot id: Q5FVX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC).
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.
messages: cytosol

8364:kcnh3
gene id: 8364:kcnh3
uniprot id: A0A6I8SHB6
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8364:rpl37
gene id: 8364:rpl37
uniprot id: A9JSC6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

8364:cldn16
gene id: 8364:cldn16
uniprot id: A0A8J0QPA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:ces3.7
gene id: 8364:ces3.7
uniprot id: A0A8J0QUC2
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:LOC100491748
gene id: 8364:LOC100491748
uniprot id: A0A8J0T2Z6
names: Subcellular Location Annotation
messages: Membrane

8364:ddc
gene id: 8364:ddc
uniprot id: Q5M8I7
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

8364:pde4c
gene id: 8364:pde4c
uniprot id: A0A6I8QS59
uniprot id: A0A6I8R6A3
uniprot id: A0A6I8SAR8
uniprot id: F6W676
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:foxo1
gene id: 8364:foxo1
uniprot id: A0A8J1J1N2
uniprot id: Q66JJ0
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: IGF1 rapidly induces phosphorylation of Thr-28, Ser-240 and Ser-303. Phosphorylation of Ser-240 decreases DNA-binding activity and promotes the phosphorylation of Thr-28, and Ser-303, which leads to nuclear exclusion and loss of function. Phosphorylation of Ser-313 is independent of IGF1 and leads to reduced function (By similarity).
messages: Nucleus
messages: Phosphorylated by AKT1; insulin-induced.
messages: Transcription factor that regulates metabolic homeostasis in response to oxidative stress. Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of sox9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Acts synergistically with atf4 to suppress osteocalcin/bglap activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of runx2, an upstream activator of osteocalcin/bglap.

8364:slc20a2
gene id: 8364:slc20a2
uniprot id: A0A6I8R9M0
uniprot id: A0A8J1JDV6
uniprot id: Q28E01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.
messages: Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis.

8364:scamp3
gene id: 8364:scamp3
uniprot id: Q566M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

8364:nmb
gene id: 8364:nmb
uniprot id: A0A6I8QFN4
uniprot id: A0A8J0R5Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted

8364:LOC105945571
gene id: 8364:LOC105945571
uniprot id: A0A8J0SCV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116407782
gene id: 8364:LOC116407782
uniprot id: A0A803KC46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:slc9b2
gene id: 8364:slc9b2
uniprot id: A4IHB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Endosome membrane
messages: Homodimer.
messages: Mitochondrion membrane
messages: Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume (By similarity).
messages: synaptic vesicle membrane

8364:mark2
gene id: 8364:mark2
uniprot id: A0A6I8Q735
uniprot id: A0A6I8S8B2
uniprot id: A0A6I8S976
uniprot id: A0A6I8SLN7
uniprot id: A0A8J0SA76
uniprot id: A0A8J1JDM4
uniprot id: A0A8J1JDM6
uniprot id: A0A8J1JG48
uniprot id: Q5BL77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

8364:mri1
gene id: 8364:mri1
uniprot id: Q0VFN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

8364:LOC101734002
gene id: 8364:LOC101734002
uniprot id: A0A8J1JWJ3
uniprot id: A0A8J1JWJ7
names: Similarity
messages: Belongs to the NXPE family.

8364:stat4
gene id: 8364:stat4
uniprot id: A0A803JQX5
uniprot id: A0A803JXQ6
uniprot id: F6UJ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8364:LOC100485294
gene id: 8364:LOC100485294
uniprot id: A0A6I8QAK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:armt1
gene id: 8364:armt1
uniprot id: A0A6I8RV51
uniprot id: A0A8J1J9H1
uniprot id: Q6DJA3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
messages: Automethylated.
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Human C6orf211 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity).
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly methylates PCNA, suggesting it is involved in the DNA damage response (By similarity).
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

8364:LOC100488539
gene id: 8364:LOC100488539
uniprot id: A0A803JLF2
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100493416
gene id: 8364:LOC100493416
uniprot id: A0A803JCM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101731100
gene id: 8364:LOC101731100
uniprot id: A0A8J0SB96
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:xpo6
gene id: 8364:xpo6
uniprot id: A0A8J0R542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

8364:LOC100487769
gene id: 8364:LOC100487769
uniprot id: A0A803KC03
uniprot id: A0A8J1IRD6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:bcas2
gene id: 8364:bcas2
uniprot id: Q6PBE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPF27 family.
messages: Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex.
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the activated spliceosome. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.

8364:rad17
gene id: 8364:rad17
uniprot id: F7BJV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

8364:cnpy1
gene id: 8364:cnpy1
uniprot id: F6WI24
names: Similarity
messages: Belongs to the canopy family.

8364:bloc1s1
gene id: 8364:bloc1s1
uniprot id: A0A8J0PJB9
uniprot id: Q0VFD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S1 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. May also play a role in intracellular vesicle trafficking. As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: cytosol

8364:slc24a4
gene id: 8364:slc24a4
uniprot id: A0A8J1IRG5
uniprot id: F6YZS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

8364:aqp4
gene id: 8364:aqp4
uniprot id: A0A6I8PZD7
uniprot id: A0A8J0QGX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:ventx1.1
gene id: 8364:ventx1.1
uniprot id: B0BME3
names: Subcellular Location Annotation
messages: Nucleus

8364:diaph1
gene id: 8364:diaph1
uniprot id: A0A8J0SI85
uniprot id: A0A8J0SJH2
uniprot id: A0A8J1JCB0
uniprot id: A0A8J1JDD4
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

8364:lta
gene id: 8364:lta
uniprot id: A0A803KAF3
uniprot id: A9JPI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane

8364:dao
gene id: 8364:dao
uniprot id: A0A6I8QWG7
uniprot id: Q0VGX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

8364:ctdnep1
gene id: 8364:ctdnep1
uniprot id: Q28HW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dullard family.
messages: Interacts with bmpr1a, bmpr1b and bmpr2.
messages: Membrane
messages: Serine/threonine protein phosphatase that may dephosphorylate and activate lipins. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. Induces neuronal differentiation by antagonizing BMP signaling. Acts both by dephosphorylating BMPR1A and by promoting BMPR2 proteasomal degradation (By similarity).
messages: perinuclear region

8364:ddx3x
gene id: 8364:ddx3x
uniprot id: A0A6I8R4B6
uniprot id: Q6P4J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:adgrg6
gene id: 8364:adgrg6
uniprot id: A0A803J5P6
uniprot id: A0A803JFK3
uniprot id: A0A8J1JJ20
uniprot id: A0A8J1JJ21
uniprot id: A0A8J1JJ23
uniprot id: A0A8J1JJ24
uniprot id: A0A8J1JLH4
uniprot id: A0A8J1JLH9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:psen1
gene id: 8364:psen1
uniprot id: A0A803K579
uniprot id: A0A803KHG8
uniprot id: Q6P2Y8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

8364:insig2
gene id: 8364:insig2
uniprot id: Q5U4Q2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INSIG family.
messages: Binds oxysterols in a pocket within their transmembrane domains and interacts with scap via transmembrane domains 3 and 4.
messages: Endoplasmic reticulum membrane
messages: Interacts with scap; interaction is direct and only takes place in the presence of sterols; it prevents interaction between scap and the coat protein complex II (COPII). Associates with the SCAP-SREBP complex; association is mediated via its interaction with scap and only takes place in the presence of sterols.
messages: Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of scap and degradation of hmgcr. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with scap and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with scap, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing scap from escorting SREBPs to the Golgi. Sterol deprivation reduce oxysterol-binding, disrupting the interaction between insig2 and scap, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs. Also regulates cholesterol synthesis by regulating degradation of hmgcr.
messages: The KxHxx motif mediates association with the coatomer complex.

8364:lsm7
gene id: 8364:lsm7
uniprot id: A0A6I8R7B2
uniprot id: A0A8J0QDI3
uniprot id: A0A8J0T324
uniprot id: F6SU96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

8364:pcdha13
gene id: 8364:pcdha13
uniprot id: B0Z663
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8364:htr4
gene id: 8364:htr4
uniprot id: A0A803J9I2
uniprot id: A0A803JX13
uniprot id: A0A8J1JCF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

8364:tmc5
gene id: 8364:tmc5
uniprot id: A0A6I8PVJ5
uniprot id: A0A8J0SZL7
uniprot id: A0A8J1IU50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8364:traf1
gene id: 8364:traf1
uniprot id: A0A6I8PZP6
uniprot id: A0A803K2D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8364:LOC101735031
gene id: 8364:LOC101735031
uniprot id: A0A1B8Y774
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:sumo1
gene id: 8364:sumo1
uniprot id: Q6DEP7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with sae2, ube2i, ranbp2, pias1 and pias2 (By similarity). Interacts with sox9 and sox10 (By similarity). Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer (By similarity). Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

8364:galnt7
gene id: 8364:galnt7
uniprot id: A0A6I8RP20
uniprot id: A0A803KH10
uniprot id: Q6NX21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:mbl2
gene id: 8364:mbl2
uniprot id: A0A6I8SN86
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

8364:naif1
gene id: 8364:naif1
uniprot id: Q28GM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8364:rfx1
gene id: 8364:rfx1
uniprot id: A0A8J1JBS5
uniprot id: A0A8J1JBS7
uniprot id: A0A8J1JBS8
uniprot id: A0A8J1JE80
uniprot id: A0A8J1JF93
uniprot id: F6WM24
names: Subcellular Location Annotation
messages: Nucleus

8364:mbtps2
gene id: 8364:mbtps2
uniprot id: A0A6I8RD15
uniprot id: F6QLY7
names: Similarity
messages: Belongs to the peptidase M50A family.

8364:sorcs2
gene id: 8364:sorcs2
uniprot id: A0A6I8RWP2
uniprot id: A0A8J0QPJ7
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

8364:ntn4
gene id: 8364:ntn4
uniprot id: A0A8J1JA78
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC448069
gene id: 8364:LOC448069
uniprot id: F6U145
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

8364:stxbp5
gene id: 8364:stxbp5
uniprot id: A0A6I8Q5P2
uniprot id: A0A6I8SQI4
uniprot id: A0A803K415
uniprot id: A0A8J0QR98
uniprot id: A0A8J0QSB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8364:rassf1
gene id: 8364:rassf1
uniprot id: F6VX16
names: Subcellular Location Annotation
messages: cytoskeleton

8364:LOC105946248
gene id: 8364:LOC105946248
uniprot id: A0A8J0S6K8
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:slc10a2
gene id: 8364:slc10a2
uniprot id: A0A6I8PLD6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

8364:LOC100492197
gene id: 8364:LOC100492197
uniprot id: A0A8J0QY42
uniprot id: A0A8J0QYW8
names: Subcellular Location Annotation
messages: Nucleus

8364:mcm3
gene id: 8364:mcm3
uniprot id: A0A8J1JPV2
uniprot id: A0A8J1JSC8
uniprot id: F7CH15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

8364:med14
gene id: 8364:med14
uniprot id: A0A8J0QMC1
uniprot id: A0A8J0R0M8
uniprot id: A0A8J0R118
uniprot id: A0A8J0R1F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:LOC100489490
gene id: 8364:LOC100489490
uniprot id: A0A8J1J979
uniprot id: A0A8J1JBN8
uniprot id: F6YLN9
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:dcn
gene id: 8364:dcn
uniprot id: A4IIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

8364:mybbp1a
gene id: 8364:mybbp1a
uniprot id: A0A6I8RJC0
names: Similarity
messages: Belongs to the MYBBP1A family.

8364:copa
gene id: 8364:copa
uniprot id: B2GUD5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

8364:tmem52
gene id: 8364:tmem52
uniprot id: F6ZIA8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:fezf2
gene id: 8364:fezf2
uniprot id: Q28G88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcription repressor. Component of the regulatory cascade that controls the development of dopaminergic (DA) and serotonergic (5HT) neurons (By similarity).

8364:tmem200a
gene id: 8364:tmem200a
uniprot id: A0A803JFI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

8364:lmod1
gene id: 8364:lmod1
uniprot id: F7BD13
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

8364:aimp2
gene id: 8364:aimp2
uniprot id: A0A8J0T5Y5
uniprot id: Q6DK86
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

8364:kif3a
gene id: 8364:kif3a
uniprot id: A0A6I8R4P3
uniprot id: A0A8J0QQZ6
uniprot id: A0A8J0SS68
uniprot id: F7DHJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Cytoplasm

8364:klhl15
gene id: 8364:klhl15
uniprot id: A0A6I8RWW5
names: Subcellular Location Annotation
messages: Nucleus

8364:galr1
gene id: 8364:galr1
uniprot id: A9ULC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:lrp12
gene id: 8364:lrp12
uniprot id: A0A6I8SMS0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gpd1
gene id: 8364:gpd1
uniprot id: Q6DFQ1
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

8364:papss1
gene id: 8364:papss1
uniprot id: A0A8J1J7K1
uniprot id: Q6DIN0
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

8364:LOC100498221
gene id: 8364:LOC100498221
uniprot id: A0A8J0QRD5
uniprot id: F7B862
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:LOC116409486
gene id: 8364:LOC116409486
uniprot id: A0A8J1J806
names: Similarity
messages: Belongs to the CFAP97 family.

8364:gabrb1
gene id: 8364:gabrb1
uniprot id: A0A803KBP9
uniprot id: F6VM58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:msx1
gene id: 8364:msx1
uniprot id: Q28CZ3
names: Subcellular Location Annotation
messages: Nucleus

8364:lamtor4
gene id: 8364:lamtor4
uniprot id: A0A8J1J6H1
uniprot id: A9UMU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMTOR4 family.
messages: Lysosome
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity).

8364:LOC101730288
gene id: 8364:LOC101730288
uniprot id: A0A1B8Y8N5
names: Subcellular Location Annotation
messages: Membrane

8364:adi1
gene id: 8364:adi1
uniprot id: Q6DIY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

8364:chat
gene id: 8364:chat
uniprot id: A0A8J0QJ80
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

8364:pomt2
gene id: 8364:pomt2
uniprot id: A0A6I8QLH7
uniprot id: A0A8J0R432
uniprot id: A0A8J0SWI8
uniprot id: A0A8J1ITX9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

8364:hdx
gene id: 8364:hdx
uniprot id: A0A6I8PJ98
uniprot id: A0A8J0SXF1
names: Subcellular Location Annotation
messages: Nucleus

8364:dapk3
gene id: 8364:dapk3
uniprot id: A0A8J0SP46
uniprot id: Q28F04
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100492379
gene id: 8364:LOC100492379
uniprot id: A0A803JVQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:phka1
gene id: 8364:phka1
uniprot id: A0A6I8RMF2
uniprot id: A0A8J1IKZ1
uniprot id: B2GUN6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

8364:t2r5
gene id: 8364:t2r5
uniprot id: Q2AB76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:ube2r2
gene id: 8364:ube2r2
uniprot id: Q08CX4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:polr1c
gene id: 8364:polr1c
uniprot id: A0A803JU27
uniprot id: A0A8J1JIK9
uniprot id: A0A8J1JIL0
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

8364:h2ac7
gene id: 8364:h2ac7
uniprot id: Q28F61
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:slc25a53
gene id: 8364:slc25a53
uniprot id: F6W124
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:abhd14a
gene id: 8364:abhd14a
uniprot id: F7AUJ0
names: Similarity
messages: Belongs to the DIP2 family.

8364:LOC108647437
gene id: 8364:LOC108647437
uniprot id: A0A8J1JI86
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100493016
gene id: 8364:LOC100493016
uniprot id: A0A8J1JAW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:stim1
gene id: 8364:stim1
uniprot id: A0A6I8T1U1
uniprot id: A0A8J1J1F4
uniprot id: A0A8J1J1F6
uniprot id: A0A8J1J1G1
uniprot id: A0A8J1J1G2
uniprot id: A0A8J1J4V0
uniprot id: Q6NZH3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:adprhl1
gene id: 8364:adprhl1
uniprot id: A0A803J5K3
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

8364:serpinf2
gene id: 8364:serpinf2
uniprot id: A0A8J0QQ54
names: Similarity
messages: Belongs to the serpin family.

8364:srp68
gene id: 8364:srp68
uniprot id: F7C3L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

8364:spire2
gene id: 8364:spire2
uniprot id: A0A8J0R2L6
uniprot id: F6PTD6
uniprot id: F6X3Q1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.
messages: cytoskeleton

8364:igf1r
gene id: 8364:igf1r
uniprot id: A0A6I8RT94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

8364:LOC734009
gene id: 8364:LOC734009
uniprot id: A0A803KAV4
uniprot id: Q28FK2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

8364:LOC116411035
gene id: 8364:LOC116411035
uniprot id: A0A8J1JLA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:recql5
gene id: 8364:recql5
uniprot id: A0A803JMM0
uniprot id: A0A803K7M1
uniprot id: B4F6V5
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

8364:glp1r
gene id: 8364:glp1r
uniprot id: A0A8J1JJL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:smdt1
gene id: 8364:smdt1
uniprot id: Q28ED6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with mcu (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling.
messages: Mitochondrion inner membrane

8364:LOC116411687
gene id: 8364:LOC116411687
uniprot id: A0A8J1JUQ2
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:LOC100145328
gene id: 8364:LOC100145328
uniprot id: B1H1A6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:mfn1
gene id: 8364:mfn1
uniprot id: Q28FR9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

8364:slc41a3
gene id: 8364:slc41a3
uniprot id: A0A8J1JGN4
uniprot id: F6UH82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

8364:cab39
gene id: 8364:cab39
uniprot id: A0A6I8RGL0
uniprot id: A0A6I8SIH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

8364:LOC100495033
gene id: 8364:LOC100495033
uniprot id: A0A8J0R3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:ercc4
gene id: 8364:ercc4
uniprot id: A0A8J0QMY5
uniprot id: A0A8J1IW79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

8364:afg3l2
gene id: 8364:afg3l2
uniprot id: A0JM92
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

8364:krtcap3
gene id: 8364:krtcap3
uniprot id: A0A8J1JHY8
uniprot id: Q6GLA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

8364:ca9
gene id: 8364:ca9
uniprot id: A0A803JZ88
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:phf10
gene id: 8364:phf10
uniprot id: A0A6I8QWD6
uniprot id: A0A6I8RVL5
uniprot id: A0A8J0SNZ2
uniprot id: A0A8J0T2V4
uniprot id: Q5BJ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

8364:mical2
gene id: 8364:mical2
uniprot id: A0A5S6M744
uniprot id: A0A803JX75
uniprot id: A0A8J1JEG3
uniprot id: A0A8J1JEG5
uniprot id: A0A8J1JHY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

8364:scrn3
gene id: 8364:scrn3
uniprot id: A0A8J0T727
uniprot id: F7EB85
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

8364:ddx54
gene id: 8364:ddx54
uniprot id: A0A6I8RLJ3
uniprot id: A0A8J0T022
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: Cytoplasm
messages: Nucleus

8364:ldlrad4
gene id: 8364:ldlrad4
uniprot id: A0A6I8Q3C9
uniprot id: A0A6I8QDY2
uniprot id: A0A6I8QLX9
uniprot id: A0A8J0R2B2
uniprot id: F7E827
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Belongs to the RAPGEF2 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:gabrg3
gene id: 8364:gabrg3
uniprot id: A0A803JLM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:ffar3
gene id: 8364:ffar3
uniprot id: A0A8J0QUL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:LOC101733755
gene id: 8364:LOC101733755
uniprot id: A0A8J1J8H7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:mycbp
gene id: 8364:mycbp
uniprot id: Q28FI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AMY1 family.
messages: Nucleus

8364:sec22c
gene id: 8364:sec22c
uniprot id: A0A6I8SYN0
uniprot id: F6QNU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

8364:psmg1
gene id: 8364:psmg1
uniprot id: A4IHY1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Degraded by the proteasome upon completion of 20S proteasome maturation.
messages: Endoplasmic reticulum
messages: Forms a heterodimer with psmg2.

8364:itpr1
gene id: 8364:itpr1
uniprot id: A0A8J0SCQ7
uniprot id: A0A8J0SJM3
uniprot id: A0A8J0SMD1
uniprot id: A0A8J0STK8
uniprot id: A0A8J0T0L5
uniprot id: A0A8J0T3U5
uniprot id: A0A8J1JGK8
uniprot id: A0A8J1JGL0
uniprot id: A0A8J1JGL3
uniprot id: A0A8J1JJ13
uniprot id: A0A8J1JK37
uniprot id: A0A8J1JK43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

8364:mixer
gene id: 8364:mixer
uniprot id: Q4JF53
names: Subcellular Location Annotation
messages: Nucleus

8364:ubl3
gene id: 8364:ubl3
uniprot id: B0BM44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:klc4
gene id: 8364:klc4
uniprot id: B5DE91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

8364:LOC116407582
gene id: 8364:LOC116407582
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116409608
gene id: 8364:LOC116409608
uniprot id: A0A8J1J8K2
names: Subcellular Location Annotation
messages: Membrane

8364:amacr
gene id: 8364:amacr
uniprot id: Q68EP6
names: Similarity
messages: Belongs to the CoA-transferase III family.

8364:mmgt1
gene id: 8364:mmgt1
uniprot id: Q28HV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Component of the ER membrane protein complex (EMC).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport (By similarity).

8364:cep120
gene id: 8364:cep120
uniprot id: B1H2P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP120 family.
messages: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.
messages: centrosome

8364:arl10b
gene id: 8364:arl10b
uniprot id: A0A8J1JAU7
uniprot id: Q28F86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8364:mcmbp
gene id: 8364:mcmbp
uniprot id: A0A8J1JSJ2
uniprot id: A0A8J1JSL3
uniprot id: A0A8J1JV18
uniprot id: Q28DV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated component of the mcm complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the mcm complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the mcm complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the mcm complex. Required for sister chromatid cohesion (By similarity).
messages: Belongs to the MCMBP family.
messages: Interacts with the mcm complex: associates with the mcm3-7 complex which lacks mcm2, while it does not interact with the mcm complex when mcm2 is present (mcm2-7 complex).
messages: Nucleus

8364:dis3l2
gene id: 8364:dis3l2
uniprot id: A0A6I8R0A9
uniprot id: A0A803JTS0
uniprot id: A0A8J1JKZ0
uniprot id: A0A8J1JM38
uniprot id: Q0V9R3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

8364:chrd.1
gene id: 8364:chrd.1
uniprot id: A0A8J0SNW3
uniprot id: B5DEB6
uniprot id: F7CS05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Secreted

8364:slc35f1
gene id: 8364:slc35f1
uniprot id: A0A8J0T4F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

8364:LOC100497260
gene id: 8364:LOC100497260
uniprot id: A0A8J0SUF5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8364:msln
gene id: 8364:msln
uniprot id: A0A803JRD5
names: Similarity
messages: Belongs to the mesothelin family.

8364:tnrc6a
gene id: 8364:tnrc6a
uniprot id: A0A8J1IY59
names: Similarity
messages: Belongs to the GW182 family.

8364:bcl2l14
gene id: 8364:bcl2l14
uniprot id: B1H2Y5
uniprot id: G1K3F0
names: Similarity
messages: Belongs to the Bcl-2 family.

8364:kcng2
gene id: 8364:kcng2
uniprot id: A0A803JY15
names: Subcellular Location Annotation
messages: Membrane

8364:mmp9.2
gene id: 8364:mmp9.2
uniprot id: A0A6I8PU05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

8364:srsf1
gene id: 8364:srsf1
uniprot id: Q6DII2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Cytoplasm
messages: May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.
messages: Nucleus speckle

8364:LOC101733830
gene id: 8364:LOC101733830
uniprot id: A0A6I8QBF1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC733474
gene id: 8364:LOC733474
uniprot id: Q28IY9
names: Subcellular Location Annotation
messages: Membrane

8364:kdm4b
gene id: 8364:kdm4b
uniprot id: A0A6I8QA80
uniprot id: A0A8J0SYR0
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

8364:LOC100496129
gene id: 8364:LOC100496129
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:nkd1
gene id: 8364:nkd1
uniprot id: A0A803J5K4
uniprot id: A0A8J0SK73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8364:tcn2
gene id: 8364:tcn2
uniprot id: A9ULJ2
uniprot id: Q5M8G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

8364:LOC101735070
gene id: 8364:LOC101735070
uniprot id: A0A803J9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:sgca
gene id: 8364:sgca
uniprot id: F6X475
names: Function
names: Similarity
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

8364:b3gnt7
gene id: 8364:b3gnt7
uniprot id: Q6NX15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:hoxb3
gene id: 8364:hoxb3
uniprot id: A0A803KGW3
uniprot id: Q28E82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:gng5
gene id: 8364:gng5
uniprot id: Q0VFC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:coq8a
gene id: 8364:coq8a
uniprot id: F7A0V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

8364:scp2
gene id: 8364:scp2
uniprot id: Q5EBE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Mitochondrion
messages: Peroxisome

8364:skp1
gene id: 8364:skp1
uniprot id: Q28CT2
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.

8364:MGC108322
gene id: 8364:MGC108322
uniprot id: Q569D6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:rab3d
gene id: 8364:rab3d
uniprot id: A0A803KJ17
uniprot id: F6TBA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

8364:ppp1r15b
gene id: 8364:ppp1r15b
uniprot id: A0A8J1JU45
names: Similarity
messages: Belongs to the PPP1R15 family.

8364:mx1
gene id: 8364:mx1
uniprot id: F6W7Q9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

8364:lman1l
gene id: 8364:lman1l
uniprot id: Q28HN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

8364:adtrp
gene id: 8364:adtrp
uniprot id: A0A6I8R358
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

8364:pde7a
gene id: 8364:pde7a
uniprot id: A0A6I8Q7U0
uniprot id: A0A6I8S179
uniprot id: A0A6I8SHM8
uniprot id: A0A8J0QX24
uniprot id: A0A8J1JQU6
uniprot id: A0A8J1JTA6
uniprot id: F7BCQ1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:tmeff2
gene id: 8364:tmeff2
uniprot id: A0A6I8Q5R3
uniprot id: A0A803JCY0
uniprot id: A0A803KCP8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116412385
gene id: 8364:LOC116412385
uniprot id: A0A8J1K146
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:t2r9
gene id: 8364:t2r9
uniprot id: Q2AB72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:LOC100489267
gene id: 8364:LOC100489267
uniprot id: A0A8J0QNL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC100491799
gene id: 8364:LOC100491799
uniprot id: A0A8J0QUI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:khdrbs1
gene id: 8364:khdrbs1
uniprot id: A0A6I8QDD7
uniprot id: A0A8J0S7R2
uniprot id: Q28FP2
names: Similarity
messages: Belongs to the KHDRBS family.

8364:srpra
gene id: 8364:srpra
uniprot id: A0A8J0QU59
uniprot id: A0A8J0R620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

8364:atp5f1a
gene id: 8364:atp5f1a
uniprot id: A0A8J1JJC9
uniprot id: Q5BKH9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

8364:hprt1
gene id: 8364:hprt1
uniprot id: A0A8J0SUB9
uniprot id: Q6P2Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

8364:gfm2
gene id: 8364:gfm2
uniprot id: A0A6I8RRM6
uniprot id: A0A8J0QKA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

8364:nup107
gene id: 8364:nup107
uniprot id: A0A8J0QPV6
uniprot id: F7C7D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

8364:LOC100493148
gene id: 8364:LOC100493148
uniprot id: A0A803KA53
uniprot id: A0A8J1J302
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:septin7
gene id: 8364:septin7
uniprot id: A0A6I8QML0
uniprot id: A0A8J0R2F5
uniprot id: A0A8J0R5E6
uniprot id: A0A8J1JNC0
uniprot id: A0A8J1JNC1
uniprot id: A0A8J1JS21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium axoneme
messages: kinetochore
messages: spindle

8364:LOC100491469
gene id: 8364:LOC100491469
uniprot id: A0A8J1IXV9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8364:fars2
gene id: 8364:fars2
uniprot id: A0A8J1JP85
uniprot id: A0A8J1JRP9
uniprot id: A0A8J1JSZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

8364:arrdc4
gene id: 8364:arrdc4
uniprot id: B0BM25
names: Similarity
messages: Belongs to the arrestin family.

8364:LOC100491107
gene id: 8364:LOC100491107
uniprot id: A0A8J0QQU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8364:eno4
gene id: 8364:eno4
uniprot id: A0A6I8RAV2
uniprot id: A0A6I8SJG3
uniprot id: B0BM20
names: Caution
names: Similarity
messages: Although it belongs to the enolase family, Leu-332 is present instead of the conserved Glu which is expected to be an active site residue.
messages: Belongs to the enolase family.

8364:nox4
gene id: 8364:nox4
uniprot id: A0A6I8Q6C4
uniprot id: A0A6I8SMI0
uniprot id: A0A8J0SH41
names: Subcellular Location Annotation
messages: Membrane

8364:LOC108648949
gene id: 8364:LOC108648949
uniprot id: A0A8J1J1J2
names: Similarity
messages: Belongs to the tubulin family.

8364:poc1a
gene id: 8364:poc1a
uniprot id: Q28I85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat POC1 family.
messages: Interacts with pat.
messages: May play an important role in centriole assembly and/or stability and ciliogenesis.
messages: cytoskeleton

8364:prr15l
gene id: 8364:prr15l
uniprot id: A0A6I8PTB6
names: Similarity
messages: Belongs to the PRR15 family.

8364:bbox1
gene id: 8364:bbox1
uniprot id: B1WAZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

8364:klhl42
gene id: 8364:klhl42
uniprot id: F6ZXU9
names: Similarity
messages: Belongs to the ferlin family.

8364:hpse2
gene id: 8364:hpse2
uniprot id: A0A803K3N9
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

8364:sspo
gene id: 8364:sspo
uniprot id: A0A8J1JRZ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular space

8364:slc23a3
gene id: 8364:slc23a3
uniprot id: A0A8J0SZQ1
uniprot id: F6WZA7
names: Subcellular Location Annotation
messages: Membrane

8364:scube1
gene id: 8364:scube1
uniprot id: A0A6I8PY14
uniprot id: A0A6I8QF84
uniprot id: A0A6I8QK33
uniprot id: A0A6I8QNS6
uniprot id: A0A6I8SR98
uniprot id: A0A8J1J917
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:arl2
gene id: 8364:arl2
uniprot id: F7BJL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

8364:mtfr2
gene id: 8364:mtfr2
uniprot id: F6XXP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

8364:lypla2
gene id: 8364:lypla2
uniprot id: F6W8J5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

8364:alas1
gene id: 8364:alas1
uniprot id: Q66JC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

8364:hscb
gene id: 8364:hscb
uniprot id: A0A6I8PSW4
uniprot id: A0A8J0PLS4
uniprot id: A0A8J0SU96
uniprot id: Q0V9B2
names: Similarity
messages: Belongs to the HscB family.

8364:smpd2
gene id: 8364:smpd2
uniprot id: B0JZW9
uniprot id: F7BY08
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

8364:LOC100487179
gene id: 8364:LOC100487179
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:hook2
gene id: 8364:hook2
uniprot id: F6THI1
uniprot id: F6VBN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Belongs to the hook family.
messages: Nucleus
messages: cytoskeleton

8364:krt34
gene id: 8364:krt34
uniprot id: A0A6I8R4B3
names: Similarity
messages: Belongs to the intermediate filament family.

8364:snx13
gene id: 8364:snx13
uniprot id: A0A6I8QQM7
uniprot id: A0A6I8S7J4
uniprot id: A0A8J1JRY5
names: Similarity
messages: Belongs to the sorting nexin family.

8364:ctnnd2
gene id: 8364:ctnnd2
uniprot id: A0A6I8QYB0
uniprot id: A0A8J1JNS2
uniprot id: A0A8J1JNS7
uniprot id: A0A8J1JNT2
uniprot id: A0A8J1JNT4
uniprot id: A0A8J1JNT7
uniprot id: A0A8J1JNT8
uniprot id: A0A8J1JNU1
uniprot id: A0A8J1JR85
uniprot id: A0A8J1JR94
uniprot id: A0A8J1JSJ5
uniprot id: A0A8J1JSK0
names: Similarity
messages: Belongs to the beta-catenin family.

8364:fbxl15
gene id: 8364:fbxl15
uniprot id: Q5XGC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBXL15 family.
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15).
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway). Required for dorsal/ventral pattern formation (By similarity.

8364:tmem178.2
gene id: 8364:tmem178.2
uniprot id: F6V1J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM178 family.
messages: Membrane

8364:dtnbp1
gene id: 8364:dtnbp1
uniprot id: A0A6I8QBZ4
uniprot id: A0A8J1JML8
uniprot id: F6VLG3
names: Similarity
messages: Belongs to the dysbindin family.

8364:LOC100487393
gene id: 8364:LOC100487393
uniprot id: A0A8J1JBB3
names: Subcellular Location Annotation
messages: Membrane

8364:pde1b
gene id: 8364:pde1b
uniprot id: A0A6I8R788
uniprot id: A0A8J1J324
uniprot id: A1L1D8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:tfap2d
gene id: 8364:tfap2d
uniprot id: A0A6I8QXV9
uniprot id: A0A8J1JM23
names: Similarity
messages: Belongs to the AP-2 family.

8364:chrnb2
gene id: 8364:chrnb2
uniprot id: A4IIS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:LOC100494633
gene id: 8364:LOC100494633
uniprot id: L7N325
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:alg9
gene id: 8364:alg9
uniprot id: A0A6I8SNQ0
uniprot id: A0A8J0QLI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100497957
gene id: 8364:LOC100497957
uniprot id: A0A8J0QRK3
uniprot id: A0A8J0R854
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:slc43a2
gene id: 8364:slc43a2
uniprot id: A4IHK6
uniprot id: F6VVJ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
messages: Cell membrane
messages: Glycosylated.
messages: Membrane
messages: Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine. The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent.

8364:adcy8
gene id: 8364:adcy8
uniprot id: A0A6I8SC40
uniprot id: A0A6I8SFS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

8364:id2
gene id: 8364:id2
uniprot id: Q6PBD7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer with other HLH proteins.
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Inhibits the activity of both neurogenic (neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors. May play a role in the regulation of the circadian clock (By similarity).

8364:adgrg1
gene id: 8364:adgrg1
uniprot id: A0A8J1JFP9
uniprot id: A0A8J1JFQ1
names: Subcellular Location Annotation
messages: Membrane
messages: Membrane raft
messages: Secreted

8364:LOC116406808
gene id: 8364:LOC116406808
uniprot id: A0A8J1IS63
names: Subcellular Location Annotation
messages: Membrane

8364:fam174c
gene id: 8364:fam174c
uniprot id: Q28HB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

8364:adgrb2
gene id: 8364:adgrb2
uniprot id: A0A6I8QAT9
uniprot id: A0A6I8SBY1
uniprot id: A0A8J0QRS2
uniprot id: A0A8J0R8D7
uniprot id: A0A8J1J4G5
names: Subcellular Location Annotation
messages: Membrane

8364:h1-6
gene id: 8364:h1-6
uniprot id: A0A8J0QYN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:mfsd2a
gene id: 8364:mfsd2a
uniprot id: Q0IHM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid.

8364:f2rl2
gene id: 8364:f2rl2
uniprot id: Q28BQ5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:med24
gene id: 8364:med24
uniprot id: A0A6I8SGB0
uniprot id: A0A8J0SDT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

8364:msra.1
gene id: 8364:msra.1
uniprot id: A0A803JTZ9
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

8364:rps27l
gene id: 8364:rps27l
uniprot id: A0A8J0SHQ7
uniprot id: A0A8J1J6E4
uniprot id: A7MC60
uniprot id: F6W3I0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

8364:LOC116411062
gene id: 8364:LOC116411062
uniprot id: A0A6I8SFJ1
uniprot id: A0A8J1JLG7
names: Subcellular Location Annotation
messages: Nucleus

8364:slc7a15
gene id: 8364:slc7a15
uniprot id: Q5U4X6
names: Subcellular Location Annotation
messages: Membrane

8364:dnah5
gene id: 8364:dnah5
uniprot id: A0A8J0SS00
uniprot id: A0A8J1JNU6
uniprot id: A0A8J1JSK5
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:tspan5
gene id: 8364:tspan5
uniprot id: A0A8J1JHG6
uniprot id: F7D6P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:kmt5c
gene id: 8364:kmt5c
uniprot id: A0A8J0SQ19
uniprot id: B1WB46
names: Subcellular Location Annotation
messages: Nucleus

8364:slc2a5
gene id: 8364:slc2a5
uniprot id: Q640S8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:smarca4
gene id: 8364:smarca4
uniprot id: F7EG86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

8364:nudt19
gene id: 8364:nudt19
uniprot id: F7C9X4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

8364:sgce
gene id: 8364:sgce
uniprot id: A0A6I8RWP5
uniprot id: A0A6I8T1M4
uniprot id: A0A803JDX1
uniprot id: A0A803KEP0
uniprot id: A0A8J0SQV6
uniprot id: A0A8J1JQ04
uniprot id: A0A8J1JTQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Golgi apparatus
messages: dendrite
messages: sarcolemma

8364:mgat1
gene id: 8364:mgat1
uniprot id: Q5M7Q5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

8364:LOC116410334
gene id: 8364:LOC116410334
uniprot id: A0A8J1JIH0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:set
gene id: 8364:set
uniprot id: F6RJH1
uniprot id: Q28FE9
uniprot id: Q6P858
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

8364:gpkow
gene id: 8364:gpkow
uniprot id: F7DF73
uniprot id: Q5M7L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

8364:dnajb12
gene id: 8364:dnajb12
uniprot id: Q28ED5
names: Subcellular Location Annotation
messages: Membrane

8364:slc30a8
gene id: 8364:slc30a8
uniprot id: Q5XHB4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell membrane
messages: Each subunit of the homodimer independently transports zinc ions in a pH-dependent manner. The cytosolic pH promotes binding of zinc ions to the transporter binding site. Upon change into the organelle-facing conformation, the two histidines of the zinc-binding site get protonated at lumenal lower pH, triggering zinc release into the organelle. The transporter then moves back to the cytosolic-facing conformation where the two histidines get deprotonated at higher pH, resulting in a net antiport of 2 protons.
messages: Homodimer.
messages: Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion.
messages: secretory vesicle membrane

8364:mtus1
gene id: 8364:mtus1
uniprot id: A0A6I8QDR7
uniprot id: A0A7D9NL64
uniprot id: A0A803JKQ7
uniprot id: A0A8J0SW46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTUS1 family.
messages: Nucleus

8364:dpm2
gene id: 8364:dpm2
uniprot id: A9ULA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

8364:itgb3
gene id: 8364:itgb3
uniprot id: A0A6I8QUX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

8364:mterf3
gene id: 8364:mterf3
uniprot id: A0A8J0R264
uniprot id: A0A8J0SRH7
names: Similarity
messages: Belongs to the mTERF family.

8364:LOC100492960
gene id: 8364:LOC100492960
uniprot id: A0A8J1IV33
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC116407779
gene id: 8364:LOC116407779
uniprot id: A0A8J1IVN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:pih1d3
gene id: 8364:pih1d3
uniprot id: A0A6I8PU68
names: Similarity
messages: Belongs to the PIH1 family.

8364:rnf40
gene id: 8364:rnf40
uniprot id: A0A6I8RG91
uniprot id: A0A8J0R3D2
uniprot id: A0A8J0R6X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

8364:map1lc3c
gene id: 8364:map1lc3c
uniprot id: Q28FC7
names: Similarity
messages: Belongs to the ATG8 family.

8364:sgk3
gene id: 8364:sgk3
uniprot id: A0A6I8Q7I4
uniprot id: A0A8J0R030
uniprot id: A0A8J0R284
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

8364:LOC100495230
gene id: 8364:LOC100495230
uniprot id: A0A8J0SIS2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:rps6ka1
gene id: 8364:rps6ka1
uniprot id: A0A6I8QM95
uniprot id: A0A6I8RUG3
uniprot id: A0A6I8SXX2
uniprot id: A0A6I8T0R1
uniprot id: A0A8J1J4D7
uniprot id: B1WAT6
uniprot id: F6YKQ4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8364:tapt1
gene id: 8364:tapt1
uniprot id: A0A6I8SF77
uniprot id: F6WHI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

8364:LOC116410940
gene id: 8364:LOC116410940
uniprot id: A0A803JUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:scfd1
gene id: 8364:scfd1
uniprot id: B4F6K9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

8364:tbx21
gene id: 8364:tbx21
uniprot id: A0A6I8PUN9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:pex3
gene id: 8364:pex3
uniprot id: Q28F64
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

8364:mpl
gene id: 8364:mpl
uniprot id: A0A6I8QQL4
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.

8364:enpp1
gene id: 8364:enpp1
uniprot id: A0A6I8SLY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Secreted

8364:plk3
gene id: 8364:plk3
uniprot id: A0A8J0SI64
uniprot id: F6ZDC6
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

8364:gnptab
gene id: 8364:gnptab
uniprot id: A0A8J0S8S2
uniprot id: A0A8J0SHB1
uniprot id: A1A5F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

8364:cenpl
gene id: 8364:cenpl
uniprot id: F6R6U8
uniprot id: Q28HN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere

8364:pdcl3
gene id: 8364:pdcl3
uniprot id: A0A803J208
uniprot id: Q5M7M0
names: Similarity
messages: Belongs to the phosducin family.

8364:pxylp1
gene id: 8364:pxylp1
uniprot id: Q0IHQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family.
messages: Golgi apparatus membrane
messages: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.

8364:tufm
gene id: 8364:tufm
uniprot id: A0A8J1IU89
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

8364:LOC101730344
gene id: 8364:LOC101730344
uniprot id: A0A8J0QX52
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100497670
gene id: 8364:LOC100497670
uniprot id: A0A8J1IZE7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105948120
gene id: 8364:LOC105948120
uniprot id: A0A8J1IT16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:psme2
gene id: 8364:psme2
uniprot id: Q5HZU3
names: Similarity
messages: Belongs to the PA28 family.

8364:atp5mc1
gene id: 8364:atp5mc1
uniprot id: Q6DEP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

8364:septin4
gene id: 8364:septin4
uniprot id: A0A8J0QME6
uniprot id: A0A8J0R115
uniprot id: A0A8J1J6C3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8364:aste1
gene id: 8364:aste1
uniprot id: B2GUH0
names: Similarity
messages: Belongs to the asteroid family.

8364:clul1
gene id: 8364:clul1
uniprot id: A0A6I8QZ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Secreted

8364:adprhl2
gene id: 8364:adprhl2
uniprot id: Q28FQ6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (By similarity). Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
messages: Belongs to the ADP-ribosylglycohydrolase family.
messages: Binds 2 magnesium ions per subunit.
messages: Chromosome
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: The protein undergoes a dramatic conformational switch from closed to open states upon substrate-binding, which enables specific substrate recognition for the 1''-O-linkage. The glutamate flap (Glu-27) blocks substrate entrance to Mg(2+) in the unliganded closed state. In presence of substrate, Glu-27 is ejected from the active site: this closed-to-open transition significantly widens the substrate-binding channel and precisely positions the scissile 1''-O-linkage for cleavage while securing tightly 2'- and 3'-hydroxyls of ADP-ribose.

8364:sftpc
gene id: 8364:sftpc
uniprot id: A0A6I8PPP7
uniprot id: B3DM51
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

8364:LOC101731479
gene id: 8364:LOC101731479
uniprot id: A0A8J0R585
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:echdc1
gene id: 8364:echdc1
uniprot id: A0A803JQY9
uniprot id: A0A8J1JI46
uniprot id: Q28C91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level.
messages: cytosol

8364:LOC100486333
gene id: 8364:LOC100486333
uniprot id: A0A6I8SAH4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC116408029
gene id: 8364:LOC116408029
uniprot id: A0A8J1J0S7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8364:slc39a14
gene id: 8364:slc39a14
uniprot id: A0A5S6LN42
uniprot id: A4IGY6
uniprot id: F6PU00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Early endosome membrane
messages: Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (By similarity). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions. Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity).
messages: Homotrimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

8364:zfp36l2.1
gene id: 8364:zfp36l2.1
uniprot id: A0A803K8N5
uniprot id: F6YWD5
uniprot id: Q28DF9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

8364:f5
gene id: 8364:f5
uniprot id: A0A6I8R4W9
names: Similarity
messages: Belongs to the multicopper oxidase family.

8364:mrps6
gene id: 8364:mrps6
uniprot id: A4IGR2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

8364:furin
gene id: 8364:furin
uniprot id: A0A6I8S5W7
uniprot id: F7CEB1
names: Similarity
messages: Belongs to the peptidase S8 family.

8364:akap12
gene id: 8364:akap12
uniprot id: A0A6I8QT52
uniprot id: A0A6I8SFS0
names: Subcellular Location Annotation
messages: Membrane

8364:crygdl.19
gene id: 8364:crygdl.19
uniprot id: A0A6I8Q3Q8
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:ppp1r10
gene id: 8364:ppp1r10
uniprot id: A0A8J0QVA2
uniprot id: A0A8J0R6D4
names: Subcellular Location Annotation
messages: Nucleus

8364:eps8l1
gene id: 8364:eps8l1
uniprot id: A0A8J0QUD8
uniprot id: A0A8J1JXK1
uniprot id: F6T1G3
names: Similarity
messages: Belongs to the EPS8 family.

8364:crybg1
gene id: 8364:crybg1
uniprot id: A0A803JDJ1
uniprot id: A0A803JZ21
uniprot id: A0A803K060
uniprot id: F7AXB9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:phka2
gene id: 8364:phka2
uniprot id: A0A8J0S894
uniprot id: A0A8J0SDK2
uniprot id: A0A8J1J6G0
uniprot id: F6WBB6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

8364:oprm1
gene id: 8364:oprm1
uniprot id: A0A803J6T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

8364:LOC100490476
gene id: 8364:LOC100490476
uniprot id: A0A6I8Q3B8
uniprot id: A0A8J0SPX2
uniprot id: F6U738
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Belongs to the liprin family. Liprin-alpha subfamily.

8364:arsj
gene id: 8364:arsj
uniprot id: A0A7D9N0J1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8364:ndufb2
gene id: 8364:ndufb2
uniprot id: F7A0M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8364:LOC116412180
gene id: 8364:LOC116412180
uniprot id: A0A8J1JUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:tff3.8
gene id: 8364:tff3.8
uniprot id: A0A803KDC0
uniprot id: F6Y5Z0
uniprot id: F7AZ82
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FPG family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:ccdc71l
gene id: 8364:ccdc71l
uniprot id: F6T195
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:tmem168
gene id: 8364:tmem168
uniprot id: F7CUB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

8364:LOC100496974
gene id: 8364:LOC100496974
uniprot id: A0A8J0R2W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:LOC100486148
gene id: 8364:LOC100486148
uniprot id: A0A8J0QU21
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:st6galnac1
gene id: 8364:st6galnac1
uniprot id: A0A6I8Q3P9
uniprot id: A0A8J0R734
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:pus3
gene id: 8364:pus3
uniprot id: F6ZXE9
uniprot id: Q6P815
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

8364:kdm2a
gene id: 8364:kdm2a
uniprot id: Q5U263
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis (By similarity). May play a role in the regulation of circadian gene expression (By similarity).
messages: The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated.
messages: The JmjC domain mediates demethylation activity and is required for satellite silencing.
messages: nucleoplasm

8364:myadml2
gene id: 8364:myadml2
uniprot id: F7D3L4
names: Subcellular Location Annotation
messages: Membrane

8364:cdt1
gene id: 8364:cdt1
uniprot id: F6SP82
names: Similarity
messages: Belongs to the Cdt1 family.

8364:LOC116408033
gene id: 8364:LOC116408033
uniprot id: A8E6F4
names: Subcellular Location Annotation
messages: Secreted

8364:coq7
gene id: 8364:coq7
uniprot id: A0A803KKL4
uniprot id: F7DI76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

8364:gadd45g
gene id: 8364:gadd45g
uniprot id: Q6DIJ3
names: Similarity
messages: Belongs to the GADD45 family.

8364:LOC100485006
gene id: 8364:LOC100485006
uniprot id: A0A8J1JLF3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ywhaq
gene id: 8364:ywhaq
uniprot id: Q5BL40
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.

8364:pnrc2
gene id: 8364:pnrc2
uniprot id: Q68EQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
messages: Nucleus
messages: P-body

8364:LOC100493771
gene id: 8364:LOC100493771
uniprot id: A0A6I8PNT7
uniprot id: A0A8J0QTC6
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

8364:atp2c2
gene id: 8364:atp2c2
uniprot id: Q0P4N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:tubb3
gene id: 8364:tubb3
uniprot id: L7N3Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8364:cep57l1
gene id: 8364:cep57l1
uniprot id: A0A6I8S8Q1
uniprot id: A0A8J0SMV5
uniprot id: A0A8J0SP43
uniprot id: Q28BZ7
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translokin family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Interacts with clip1, mis12, ndc80 and zwint. Interacts with gamma-tubulin (By similarity).
messages: Required for spindle microtubule attachment to both kinetochores and centrosomes. Also functions to tether minus-ends of spindle microtubules to centrosomes. May act by forming ring-like structures around microtubules, or by serving as a cross-linker or scaffold at the attachment site (By similarity).
messages: centrosome
messages: kinetochore
messages: spindle

8364:lamtor2
gene id: 8364:lamtor2
uniprot id: Q6DF40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAMAD family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).

8364:gpc4
gene id: 8364:gpc4
uniprot id: F7CR54
uniprot id: F7D6Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Belongs to the syndecan proteoglycan family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: Membrane

8364:acvrl1
gene id: 8364:acvrl1
uniprot id: A0A6I8PLJ4
uniprot id: A0A8J1J8K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8364:plppr5
gene id: 8364:plppr5
uniprot id: A0A6I8RZN5
uniprot id: A0A8J0QKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8364:LOC100489821
gene id: 8364:LOC100489821
uniprot id: A0A8J1J983
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:sec22a
gene id: 8364:sec22a
uniprot id: Q6DFM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

8364:plod3
gene id: 8364:plod3
uniprot id: Q28BS2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8364:yipf5
gene id: 8364:yipf5
uniprot id: A0A8J0T293
uniprot id: Q66KA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.
messages: cis-Golgi network membrane

8364:dnase1
gene id: 8364:dnase1
uniprot id: A0A803JID4
uniprot id: F6W656
names: Similarity
messages: Belongs to the DNase I family.

8364:cul4b
gene id: 8364:cul4b
uniprot id: A0A8J0T4Z3
uniprot id: A0A8J0T621
uniprot id: B2GU90
names: Similarity
messages: Belongs to the cullin family.

8364:aoc2
gene id: 8364:aoc2
uniprot id: A0A8J1J164
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

8364:rgs14
gene id: 8364:rgs14
uniprot id: A0A6I8RCY0
uniprot id: A0A6I8SP90
uniprot id: A0A8J1JDI4
names: Subcellular Location Annotation
messages: dendrite

8364:ptges
gene id: 8364:ptges
uniprot id: A9ULK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

8364:nop53
gene id: 8364:nop53
uniprot id: F7CTZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

8364:LOC101735291
gene id: 8364:LOC101735291
uniprot id: A0A8J1J820
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dtx1
gene id: 8364:dtx1
uniprot id: A0A8J0SXT9
uniprot id: F7CWT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

8364:parp4
gene id: 8364:parp4
uniprot id: A0A8J1J5M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

8364:LOC108648060
gene id: 8364:LOC108648060
uniprot id: A0A803JV25
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:tac3
gene id: 8364:tac3
uniprot id: I4IYA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

8364:c6.2
gene id: 8364:c6.2
uniprot id: Q6DEX1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:nes
gene id: 8364:nes
uniprot id: A0A803JEA0
names: Similarity
messages: Belongs to the intermediate filament family.

8364:fam171a2
gene id: 8364:fam171a2
uniprot id: A0A6I8PQ13
uniprot id: A0A8J0QBA2
uniprot id: F6SPR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM171 family.
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Membrane
messages: Secreted

8364:trmt1l
gene id: 8364:trmt1l
uniprot id: A0A6I8PW42
uniprot id: A0A8J1JGB0
uniprot id: F6QA34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: May play a role in motor coordination and exploratory behavior.
messages: Nucleus

8364:krt12.3
gene id: 8364:krt12.3
uniprot id: B0BMG5
uniprot id: Q28IM9
names: Similarity
messages: Belongs to the intermediate filament family.

8364:cybrd1
gene id: 8364:cybrd1
uniprot id: Q5CZL8
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Binds 2 heme b groups non-covalently.
messages: Cell membrane
messages: Homodimer.
messages: Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration (By similarity). May also function as a cupric transmembrane reductase (By similarity).

8364:LOC105945968
gene id: 8364:LOC105945968
uniprot id: A0A1B8XVM9
names: Similarity
messages: Belongs to the cyclin family.

8364:ctbs
gene id: 8364:ctbs
uniprot id: Q5HZT4
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

8364:ggt1
gene id: 8364:ggt1
uniprot id: A0A8J0PDW8
uniprot id: Q6DIS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

8364:arx
gene id: 8364:arx
uniprot id: A0A6I8S3E9
names: Subcellular Location Annotation
messages: Nucleus

8364:topaz1
gene id: 8364:topaz1
uniprot id: A0A6I8RX02
uniprot id: A0A8J0QGN8
uniprot id: A0A8J0QGQ8
uniprot id: A0A8J1JRC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
messages: cytosol

8364:sh3gl3
gene id: 8364:sh3gl3
uniprot id: A0A6I8S6I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

8364:ptprn
gene id: 8364:ptprn
uniprot id: A0A6I8SWN1
uniprot id: B2GU79
uniprot id: F7A9S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

8364:LOC101735111
gene id: 8364:LOC101735111
uniprot id: F6XTM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:gdf3
gene id: 8364:gdf3
uniprot id: A0A803JTG3
uniprot id: Q66KL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Also forms heterodimers with other TGF-beta family members including nodal2/nr-2 and bmp4 (By similarity).
messages: Required for posterior mesoderm formation during embryogenesis. Acts indirectly to suppress head formation by altering mesodermal patterning. Also involved in the establishment of left-right axis asymmetry, acting upstream of nodal/nr-1. Can exert long-range effects in the embryo (By similarity).
messages: Secreted

8364:LOC100490626
gene id: 8364:LOC100490626
uniprot id: A0A1B8Y901
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC116410791
gene id: 8364:LOC116410791
uniprot id: B5DDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:psma7
gene id: 8364:psma7
uniprot id: Q6P8E6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

8364:b3gnt5
gene id: 8364:b3gnt5
uniprot id: Q6P3P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids.
messages: Golgi apparatus membrane

8364:hrh4.f2
gene id: 8364:hrh4.f2
uniprot id: A0A8J0R4M2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:slc12a1
gene id: 8364:slc12a1
uniprot id: A0A6I8PYE2
uniprot id: A0A6I8Q4V5
uniprot id: A0A8J0SJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

8364:LOC116409586
gene id: 8364:LOC116409586
uniprot id: A0A8J1J8I8
names: Subcellular Location Annotation
messages: Membrane

8364:dlx5
gene id: 8364:dlx5
uniprot id: Q6GLH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

8364:LOC100145285
gene id: 8364:LOC100145285
uniprot id: A0A8J1JHM8
uniprot id: B1H0Z9
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:tas1r1
gene id: 8364:tas1r1
uniprot id: A0A8J1JAU0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100494225
gene id: 8364:LOC100494225
uniprot id: A0A1B8Y381
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:LOC100491289
gene id: 8364:LOC100491289
uniprot id: A0A8J0QV00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116407804
gene id: 8364:LOC116407804
uniprot id: A0A8J1IVR8
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100486918
gene id: 8364:LOC100486918
uniprot id: A0A7D9NJU9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

8364:crtc2
gene id: 8364:crtc2
uniprot id: A0A803JH97
uniprot id: A0A803K6X7
uniprot id: A0A8J1IM93
uniprot id: A0A8J1IQ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

8364:psmd4
gene id: 8364:psmd4
uniprot id: A0A8J1IL39
uniprot id: Q6NVQ2
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

8364:kif3b
gene id: 8364:kif3b
uniprot id: A0A6I8Q3P2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:zfpm2
gene id: 8364:zfpm2
uniprot id: A0A803KFG0
uniprot id: F6UVY4
names: Subcellular Location Annotation
messages: Nucleus

8364:rps12
gene id: 8364:rps12
uniprot id: A0A8J0SE13
uniprot id: Q68EP7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

8364:wdr6
gene id: 8364:wdr6
uniprot id: F6UJR2
names: Similarity
messages: Belongs to the CARF family.

8364:slc7a6os
gene id: 8364:slc7a6os
uniprot id: A0A6I8SF51
uniprot id: A0A8J0SKE0
uniprot id: Q28GL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

8364:vsig1
gene id: 8364:vsig1
uniprot id: A8WH11
uniprot id: F6U0Y3
names: Subcellular Location Annotation
messages: Membrane

8364:adh1
gene id: 8364:adh1
uniprot id: A0A8J1JBB4
uniprot id: Q5M7K9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8364:MGC147402
gene id: 8364:MGC147402
uniprot id: A0A6I8PPP1
uniprot id: Q08D08
names: Similarity
messages: Belongs to the HMGA family.

8364:LOC108646262
gene id: 8364:LOC108646262
uniprot id: A0A8J0SZQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:prpf3
gene id: 8364:prpf3
uniprot id: F7B9I0
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

8364:mrpl45
gene id: 8364:mrpl45
uniprot id: Q4QQQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL45 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

8364:neurl2
gene id: 8364:neurl2
uniprot id: F7CZK9
uniprot id: K9J7Q5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

8364:mboat7
gene id: 8364:mboat7
uniprot id: A0A6I8SZ57
names: Subcellular Location Annotation
messages: Membrane

8364:ocm4.5
gene id: 8364:ocm4.5
uniprot id: B0JZ24
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8364:LOC100485167
gene id: 8364:LOC100485167
uniprot id: A0A6I8RZT1
uniprot id: A0A8J0QQ05
names: Similarity
messages: Belongs to the MHC class I family.

8364:kcng4
gene id: 8364:kcng4
uniprot id: F6Y7C6
names: Subcellular Location Annotation
messages: Membrane

8364:f2rl3
gene id: 8364:f2rl3
uniprot id: F6WHY7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:slc35b3
gene id: 8364:slc35b3
uniprot id: A0A6I8QP67
uniprot id: A0A6I8S485
uniprot id: A0A8J0R076
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

8364:adgra1
gene id: 8364:adgra1
uniprot id: A0A8J0T5S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8364:tnfsf11
gene id: 8364:tnfsf11
uniprot id: F6XUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

8364:gpr89b
gene id: 8364:gpr89b
uniprot id: A0A6I8S7Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

8364:ube4b
gene id: 8364:ube4b
uniprot id: A0A6I8Q2W8
uniprot id: A0A6I8RF94
uniprot id: A0A8J0R616
uniprot id: A0A8J0T2H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

8364:kcne1
gene id: 8364:kcne1
uniprot id: A0A8J1J5X9
names: Similarity
messages: Belongs to the potassium channel KCNE family.

8364:LOC108648901
gene id: 8364:LOC108648901
uniprot id: A0A6I8RMH4
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:dnajb6
gene id: 8364:dnajb6
uniprot id: Q6P642
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity.
messages: Homooligomer.
messages: Nucleus
messages: perinuclear region

8364:dnase1l2
gene id: 8364:dnase1l2
uniprot id: A0A6I8S5T0
names: Similarity
messages: Belongs to the DNase I family.

8364:lsm14b
gene id: 8364:lsm14b
uniprot id: A0A6I8SMH2
uniprot id: Q566L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LSM14 family.
messages: Component of a ribonucleoprotein (RNP) complex, at least composed of cpeb1, lsm14b/rap55b, ddx6/Xp54, ybx2/frgy2, pat1/P100, eif4enif1/4E-T and eif4e1b. Different translationally-repressed mRNP complexes probably exist that contain either lsm14a/rap55a or lsm14b/rap55b depending on the developmental stage. Component of a ribonucleoprotein (RNP) complex, composed at least of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen (By similarity).
messages: May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (By similarity).

8364:aifm1
gene id: 8364:aifm1
uniprot id: A0A8J0SL28
uniprot id: Q28IZ0
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

8364:b3galt1
gene id: 8364:b3galt1
uniprot id: A0A803J8Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC496989
gene id: 8364:LOC496989
uniprot id: A0A6I8PSI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

8364:uimc1
gene id: 8364:uimc1
uniprot id: A0JM80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAP80 family.
messages: Component of the BRCA1-A complex.
messages: Nucleus
messages: The tandem UIM domains form a continuous 60 Angstrom-long alpha-helix and mediate binding to 'Lys-63'-linked ubiquitins. UIM1 and UIM2 bind to the proximal and distal ubiquitin moieties and recognize an 'Ile-44'-centered hydrophobic patch. Since UIMs don't interact with the 'Lys-63' isopeptide bond the UIM-linker region between the 2 UIM domains determines the selectivity for 'Lys-63'-linkage, and its length is very important for specificity (By similarity).
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin (By similarity).

8364:slc39a12
gene id: 8364:slc39a12
uniprot id: A0A6I8PMZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

8364:inpp5a.1
gene id: 8364:inpp5a.1
uniprot id: A0A8J1JSR3
uniprot id: A0A8J1JV66
uniprot id: Q05B09
uniprot id: Q28CJ9
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

8364:fam120b
gene id: 8364:fam120b
uniprot id: A0A8J0QGL8
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

8364:LOC101733834
gene id: 8364:LOC101733834
uniprot id: A0A803JA90
uniprot id: A0A803JDX0
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

8364:fabp3
gene id: 8364:fabp3
uniprot id: Q5EB34
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8364:LOC100124775
gene id: 8364:LOC100124775
uniprot id: Q0V9Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Nucleus

8364:atp11a
gene id: 8364:atp11a
uniprot id: A0A6I8R5Q1
uniprot id: A0A6I8R9L4
uniprot id: A0A8J1J793
uniprot id: A0A8J1J893
uniprot id: F6XT62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:b3galt5.5
gene id: 8364:b3galt5.5
uniprot id: A0A8J1J4W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:gmds
gene id: 8364:gmds
uniprot id: Q28GX4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

8364:tsta3
gene id: 8364:tsta3
uniprot id: Q07G75
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

8364:prkdc
gene id: 8364:prkdc
uniprot id: A0A8J0SNX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: nucleolus

8364:vkorc1l1
gene id: 8364:vkorc1l1
uniprot id: F6T1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100488580
gene id: 8364:LOC100488580
uniprot id: A0A8J0SH32
names: Similarity
messages: Belongs to the FXYD family.

8364:ldlr
gene id: 8364:ldlr
uniprot id: A0A6I8SL03
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:dclk3
gene id: 8364:dclk3
uniprot id: A0A8J0SUT6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8364:stc2
gene id: 8364:stc2
uniprot id: A0A803KHX5
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

8364:LOC101733134
gene id: 8364:LOC101733134
uniprot id: A0A803JN77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:adck1
gene id: 8364:adck1
uniprot id: A0A8J1IND0
uniprot id: F6WM52
uniprot id: Q5M7P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (By similarity). The action of this enzyme is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable).
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Secreted

8364:eml1
gene id: 8364:eml1
uniprot id: A0A6I8QI68
uniprot id: A0A8J0SUL4
uniprot id: A0A8J0SVE2
uniprot id: Q5FVY3
names: Similarity
messages: Belongs to the WD repeat EMAP family.

8364:odf3
gene id: 8364:odf3
uniprot id: Q5EB30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF3 family.
messages: Cytoplasm

8364:irf4
gene id: 8364:irf4
uniprot id: F6YQM4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:nr1h4
gene id: 8364:nr1h4
uniprot id: A0A6I8PNY1
uniprot id: A0A6I8QNB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:t2r26
gene id: 8364:t2r26
uniprot id: Q2AB57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:ankh
gene id: 8364:ankh
uniprot id: A0A6I8T1U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

8364:eif2a
gene id: 8364:eif2a
uniprot id: A0A8J0QCW4
uniprot id: F6XD74
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

8364:stk38l
gene id: 8364:stk38l
uniprot id: Q6DIL2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:nudt5
gene id: 8364:nudt5
uniprot id: Q28I97
names: Similarity
messages: Belongs to the Nudix hydrolase family.

8364:fzd10
gene id: 8364:fzd10
uniprot id: Q6GL20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

8364:man1a1
gene id: 8364:man1a1
uniprot id: A0A6I8R7D8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8364:retreg1
gene id: 8364:retreg1
uniprot id: A0A803K2T5
uniprot id: B1H327
uniprot id: F6Q287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

8364:LOC116409544
gene id: 8364:LOC116409544
uniprot id: A0A8J1JBQ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:clca1.1
gene id: 8364:clca1.1
uniprot id: A0A8J0QGK5
uniprot id: Q5BKJ5
names: Similarity
messages: Belongs to the CLCR family.

8364:plpp5
gene id: 8364:plpp5
uniprot id: B2GUF2
uniprot id: B5DDY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8364:bpnt1
gene id: 8364:bpnt1
uniprot id: F6TC68
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8364:fam214a
gene id: 8364:fam214a
uniprot id: A0A8J0SIC1
uniprot id: Q5FW46
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Belongs to the FAM214 family.
messages: Nucleus
messages: The protein contains 2 transactivation domains (TAD). Each of these domains may be required for transcriptional activation of a subset of target genes.
messages: Transcription regulator that syncronizes transcriptional and translational programs to promote macrophage invasion of tissues.

8364:slc17a8
gene id: 8364:slc17a8
uniprot id: A0A8J0QPR2
names: Subcellular Location Annotation
messages: Membrane

8364:tmem184c
gene id: 8364:tmem184c
uniprot id: A9UM61
uniprot id: Q28CV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM184 family.
messages: May play a role in cell growth.
messages: Membrane

8364:btaf1
gene id: 8364:btaf1
uniprot id: A0A8J1JWQ9
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100485652
gene id: 8364:LOC100485652
uniprot id: A0A8J0QXN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC101733546
gene id: 8364:LOC101733546
uniprot id: A0A8J0SIS7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cyfip2
gene id: 8364:cyfip2
uniprot id: A8KBE6
names: Similarity
messages: Belongs to the CYFIP family.

8364:LOC100486258
gene id: 8364:LOC100486258
uniprot id: A0A6I8S9C8
uniprot id: A0A8J1JC37
names: Similarity
messages: Belongs to the NXPE family.

8364:pih1d2
gene id: 8364:pih1d2
uniprot id: Q5XGG3
names: Similarity
messages: Belongs to the PIH1 family.

8364:kmt2a
gene id: 8364:kmt2a
uniprot id: A0A803JEW4
uniprot id: A0A8J1JXA1
uniprot id: A0A8J1K1F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
messages: Nucleus

8364:ccdc160
gene id: 8364:ccdc160
uniprot id: A9JSR5
names: Similarity
messages: Belongs to the CCDC160 family.

8364:tm6sf1
gene id: 8364:tm6sf1
uniprot id: A0A8J1J7V5
uniprot id: A0A8J1JAA7
uniprot id: Q0V982
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Lysosome membrane
messages: May function as sterol isomerase.
messages: Membrane

8364:cldn17.3
gene id: 8364:cldn17.3
uniprot id: A0A803K6U6
uniprot id: F6ZC25
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:pdp2
gene id: 8364:pdp2
uniprot id: A0A8J0QXV9
names: Similarity
messages: Belongs to the PP2C family.

8364:doc2b
gene id: 8364:doc2b
uniprot id: A0A6I8QM45
uniprot id: F6V3G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane

8364:LOC116408073
gene id: 8364:LOC116408073
uniprot id: A0A803J315
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8364:ube2g1
gene id: 8364:ube2g1
uniprot id: Q6P888
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:LOC100492853
gene id: 8364:LOC100492853
uniprot id: A0A8J1J8H8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pmf1
gene id: 8364:pmf1
uniprot id: A9UMQ7
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

8364:LOC105948375
gene id: 8364:LOC105948375
uniprot id: A0A8J0SXP9
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100493626
gene id: 8364:LOC100493626
uniprot id: A0A8J0S6T4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:scube2
gene id: 8364:scube2
uniprot id: A0A6I8QKZ1
uniprot id: A0A6I8RX37
uniprot id: A0A6I8SQ05
uniprot id: A0A8J1JDW2
uniprot id: Q0P4R4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:sema4d
gene id: 8364:sema4d
uniprot id: A0A6I8PUV7
uniprot id: B3DLC3
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gpcpd1
gene id: 8364:gpcpd1
uniprot id: B5DDX4
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8364:sema4a
gene id: 8364:sema4a
uniprot id: A0A8J1JXX3
uniprot id: A9JRL7
uniprot id: F6V936
names: Similarity
messages: Belongs to the semaphorin family.

8364:acp1
gene id: 8364:acp1
uniprot id: A0A803K4H9
uniprot id: Q6DEU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

8364:kif7
gene id: 8364:kif7
uniprot id: A0A6I8Q555
uniprot id: A0A8J1JB48
uniprot id: A0A8J1JDK5
uniprot id: A0A8J1JEM3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:kifc1
gene id: 8364:kifc1
uniprot id: A0A8J0QUV1
uniprot id: A0A8J1IQB2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:hsbp1
gene id: 8364:hsbp1
uniprot id: A0A8J0SL79
uniprot id: Q5I0S3
names: Similarity
messages: Belongs to the HSBP1 family.

8364:nek3
gene id: 8364:nek3
uniprot id: Q6DJQ5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:aff1
gene id: 8364:aff1
uniprot id: A0A7D9NKS0
uniprot id: A0A8J0SX05
uniprot id: A0A8J1JNC6
names: Similarity
messages: Belongs to the AF4 family.

8364:ndufaf4
gene id: 8364:ndufaf4
uniprot id: B5DEA5
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

8364:numbl
gene id: 8364:numbl
uniprot id: A0A6I8RU70
names: Function
messages: Plays a role in the process of neurogenesis.

8364:cyp8b1.1
gene id: 8364:cyp8b1.1
uniprot id: A0A803JLB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

8364:usp16
gene id: 8364:usp16
uniprot id: A0A8J0SC33
uniprot id: Q0VA64
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Homotetramer.
messages: Nucleus
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

8364:LOC101730723
gene id: 8364:LOC101730723
uniprot id: F6QJR9
names: Subcellular Location Annotation
messages: Nucleus

8364:agr2
gene id: 8364:agr2
uniprot id: Q28ID5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AGR family.
messages: Endoplasmic reticulum
messages: Monomer and homodimer.
messages: Secreted

8364:irf2
gene id: 8364:irf2
uniprot id: A0A8J1J9G5
uniprot id: Q66JJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:cldn8.3
gene id: 8364:cldn8.3
uniprot id: A0A803K8Z6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:hrh4.g1
gene id: 8364:hrh4.g1
uniprot id: A0A8J1JTU1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:fmo3
gene id: 8364:fmo3
uniprot id: Q5FW41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

8364:cldn2
gene id: 8364:cldn2
uniprot id: A0A803JKT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:slc22a18
gene id: 8364:slc22a18
uniprot id: A0A803JNH1
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116409627
gene id: 8364:LOC116409627
uniprot id: A0A8J1JB14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:nelfcd
gene id: 8364:nelfcd
uniprot id: Q566L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

8364:thoc6
gene id: 8364:thoc6
uniprot id: F7BYE1
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

8364:LOC116407545
gene id: 8364:LOC116407545
uniprot id: A0A8J1IVQ1
uniprot id: A0A8J1IWG2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:cav3.2
gene id: 8364:cav3.2
uniprot id: F7C2V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola
messages: sarcolemma

8364:LOC100492813
gene id: 8364:LOC100492813
uniprot id: F6XTM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:naxe
gene id: 8364:naxe
uniprot id: A0A5S6NBZ0
uniprot id: A0A8J0QQE6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted

8364:pex19
gene id: 8364:pex19
uniprot id: F6ZDI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

8364:trpv3
gene id: 8364:trpv3
uniprot id: A0A8J1J3Q0
uniprot id: F6UZP3
names: Subcellular Location Annotation
messages: Membrane

8364:hnrnpk
gene id: 8364:hnrnpk
uniprot id: A0A8J1J845
uniprot id: Q6P363
names: Subcellular Location Annotation
messages: nucleoplasm

8364:bicc1
gene id: 8364:bicc1
uniprot id: A0A8J1JVM3
uniprot id: F7CAX7
names: Similarity
messages: Belongs to the BicC family.

8364:got2
gene id: 8364:got2
uniprot id: Q28F67
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: Mitochondrion matrix

8364:glul
gene id: 8364:glul
uniprot id: Q6P348
names: Similarity
messages: Belongs to the glutamine synthetase family.

8364:LOC100494884
gene id: 8364:LOC100494884
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:gcnt2.2
gene id: 8364:gcnt2.2
uniprot id: A0A8J0QMB5
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

8364:atxn2
gene id: 8364:atxn2
uniprot id: A0A6I8SPK9
uniprot id: A0A8J0QT23
uniprot id: A0A8J0QUW2
uniprot id: A0A8J0QWY2
names: Similarity
messages: Belongs to the ataxin-2 family.

8364:sulf1
gene id: 8364:sulf1
uniprot id: A0A6I8PXV0
uniprot id: A0A6I8RI34
uniprot id: A0A6I8SMA3
uniprot id: A0A6I8SYV5
uniprot id: A0A8J0SPY9
uniprot id: A0A8J0SUB5
uniprot id: A0A8J1JMB2
uniprot id: A0A8J1JR04
uniprot id: A3FMN5
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8364:fbxo31
gene id: 8364:fbxo31
uniprot id: A0A6I8SM56
uniprot id: Q0D2D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBXO31 family.
messages: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

8364:ctif
gene id: 8364:ctif
uniprot id: Q0V9S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTIF family.
messages: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD) (By similarity).
messages: perinuclear region

8364:atxn10
gene id: 8364:atxn10
uniprot id: A0A8J1JAT9
uniprot id: Q5FVB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
messages: perinuclear region

8364:prkd1
gene id: 8364:prkd1
uniprot id: B2GU99
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

8364:ttc39a
gene id: 8364:ttc39a
uniprot id: Q28D40
names: Similarity
messages: Belongs to the TTC39 family.

8364:eri1
gene id: 8364:eri1
uniprot id: Q28FF6
names: Subcellular Location Annotation
messages: Cytoplasm

8364:abo2
gene id: 8364:abo2
uniprot id: A0A8J0QVZ4
uniprot id: A0A8J1IXW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:polr1d.2
gene id: 8364:polr1d.2
uniprot id: A0A803K7Z0
uniprot id: A0A8J0QS91
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

8364:spsb1
gene id: 8364:spsb1
uniprot id: A0A8J0QRI2
names: Similarity
messages: Belongs to the SPSB family.

8364:nt5dc1
gene id: 8364:nt5dc1
uniprot id: A0A6I8QGT2
uniprot id: A0A8J0QHR3
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

8364:extl2
gene id: 8364:extl2
uniprot id: Q28F88
uniprot id: Q66KC7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8364:LOC116408370
gene id: 8364:LOC116408370
uniprot id: A0A8J1IZH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:kctd2
gene id: 8364:kctd2
uniprot id: F6U7A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

8364:atp2b3
gene id: 8364:atp2b3
uniprot id: A0A6I8QKY9
uniprot id: A0A8J0SK04
uniprot id: A0A8J0SS67
uniprot id: A0A8J0STU0
uniprot id: A0A8J0SV70
uniprot id: B4F6S6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:pmm1
gene id: 8364:pmm1
uniprot id: A8E4X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

8364:c1orf174
gene id: 8364:c1orf174
uniprot id: A0JM83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

8364:rps17
gene id: 8364:rps17
uniprot id: F7B301
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

8364:luc7l
gene id: 8364:luc7l
uniprot id: A0A6I8QWD9
uniprot id: A0A803JWS7
uniprot id: A0A8J0T5S3
uniprot id: Q6GLC1
names: Similarity
messages: Belongs to the Luc7 family.

8364:slc30a1
gene id: 8364:slc30a1
uniprot id: Q66KD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8364:arih1
gene id: 8364:arih1
uniprot id: B1H1E4
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoinhibited by the ariadne domain, which masks the second RING-type zinc finger that contains the active site and inhibits the E3 activity. Inhibition is relieved upon binding to neddylated cullin-RING ubiquitin ligase complexes, which activate the E3 ligase activity of ARIH1.
messages: Belongs to the RBR family. Ariadne subfamily.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes.
messages: Interacts (via the first RING-type zinc finger) with ube2l3. Associates with cullin-RING ubiquitin ligase (CRL) complexes containing neddylated cullin.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.
messages: Nucleus
messages: The Ariadne domain inhibits activity by masking the second RING-type zinc finger that contains the active site.

8364:cd37
gene id: 8364:cd37
uniprot id: F6TSX2
uniprot id: Q5FVV2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC100489254
gene id: 8364:LOC100489254
uniprot id: A0A803JG12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8364:ccdc22
gene id: 8364:ccdc22
uniprot id: A0A6I8RA32
uniprot id: F7C4J4
uniprot id: Q28G12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC22 family.
messages: Endosome
messages: May be involved in regulation of NF-kappa-B signaling. May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).
messages: centrosome

8364:rdh7
gene id: 8364:rdh7
uniprot id: F7EET0
uniprot id: Q28I32
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:KEG17 p02
gene id: 8364:KEG17_p02
uniprot id: Q5G7H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion membrane

8364:upp2
gene id: 8364:upp2
uniprot id: A0A803KL20
uniprot id: F6SVA2
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

8364:csmd3
gene id: 8364:csmd3
uniprot id: A0A8J0T1R2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gpx4
gene id: 8364:gpx4
uniprot id: A0A8J0QH04
uniprot id: A0A8J0QH96
names: Similarity
messages: Belongs to the glutathione peroxidase family.

8364:slc29a3
gene id: 8364:slc29a3
uniprot id: A0A8J1JRM4
uniprot id: A0A8J1JRN7
uniprot id: A4IFW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

8364:abhd17c
gene id: 8364:abhd17c
uniprot id: Q6GL10
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization.
messages: Postsynaptic density membrane
messages: Recycling endosome membrane
messages: dendritic spine

8364:mrpl53
gene id: 8364:mrpl53
uniprot id: Q6DEP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

8364:LOC101731703
gene id: 8364:LOC101731703
uniprot id: A0A8J1JK38
names: Similarity
messages: Belongs to the PACS family.

8364:cd9
gene id: 8364:cd9
uniprot id: Q28EH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

8364:cox6c
gene id: 8364:cox6c
uniprot id: A0A6I8PLM3
uniprot id: Q5U402
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

8364:cad
gene id: 8364:cad
uniprot id: F7CX88
uniprot id: F7D2L7
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

8364:hmgb2
gene id: 8364:hmgb2
uniprot id: A0A803KH06
uniprot id: F7AP92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

8364:tm9sf3
gene id: 8364:tm9sf3
uniprot id: A0A6I8S2T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

8364:cenpe
gene id: 8364:cenpe
uniprot id: A0A6I8RXX0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:tspan31
gene id: 8364:tspan31
uniprot id: Q28G47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:LOC100491180
gene id: 8364:LOC100491180
uniprot id: A0A8J0QUM2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:arhgef18
gene id: 8364:arhgef18
uniprot id: A0A8J1JSW5
uniprot id: F6ZCH8
names: Subcellular Location Annotation
messages: Cytoplasm

8364:b3gnt9
gene id: 8364:b3gnt9
uniprot id: A0A6I8RAW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:pus7
gene id: 8364:pus7
uniprot id: A0A8J0SHC0
uniprot id: A0A8J0SII5
uniprot id: Q28DV4
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

8364:c20orf27
gene id: 8364:c20orf27
uniprot id: A0A803JU08
uniprot id: Q68FA2
names: Similarity
messages: Belongs to the UPF0687 family.

8364:ddx49
gene id: 8364:ddx49
uniprot id: A0A6I8RGE1
uniprot id: A0A8J0SF09
uniprot id: Q6P1S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:hes7.1
gene id: 8364:hes7.1
uniprot id: Q28HA8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Has a particular type of basic domain which includes a helix-interrupting proline.
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.
messages: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. Demarcates the prospective midbrain-hindbrain boundary (MHB) region in the neuroectoderm in early gastrulae embryos by repressing transcription of a number of target genes (By similarity).

8364:slc5a2
gene id: 8364:slc5a2
uniprot id: A0A6I8RHU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8364:darmin
gene id: 8364:darmin
uniprot id: F6RXW8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

8364:LOC101733137
gene id: 8364:LOC101733137
uniprot id: A0A8J0R7X3
uniprot id: A0A8J1JC96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8364:itih2
gene id: 8364:itih2
uniprot id: Q496Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

8364:hoxd9
gene id: 8364:hoxd9
uniprot id: A0A803K0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8364:LOC100486127
gene id: 8364:LOC100486127
uniprot id: F7BJK0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100485680
gene id: 8364:LOC100485680
uniprot id: A0A1B8Y732
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:rps3a
gene id: 8364:rps3a
uniprot id: Q642T2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Cytoplasm

8364:tmx2
gene id: 8364:tmx2
uniprot id: A0A6I8RSG8
uniprot id: Q6DFS0
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Monomer (By similarity). Homodimer; disulfide-linked (By similarity). Occurs in both reduced and oxidized monomeric form (By similarity). Oxidative conditions increase homodimerization (By similarity).
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
messages: The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.

8364:LOC116411628
gene id: 8364:LOC116411628
uniprot id: A0A8J1JQL0
uniprot id: A0A8J1JQL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:clcnkb
gene id: 8364:clcnkb
uniprot id: A0A803K8V2
uniprot id: A0A8J1JFQ7
names: Subcellular Location Annotation
messages: Membrane

8364:fam49a
gene id: 8364:fam49a
uniprot id: Q28DJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

8364:atg5
gene id: 8364:atg5
uniprot id: A0A6I8Q192
uniprot id: A0A8J0SNW9
uniprot id: A0A8J1JI71
uniprot id: A0A8J1JI74
uniprot id: B1WB05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

8364:LOC100488183
gene id: 8364:LOC100488183
uniprot id: A0A803K3W0
names: Subcellular Location Annotation
messages: centrosome
messages: perinuclear region

8364:crybg2
gene id: 8364:crybg2
uniprot id: A0A6I8QIH0
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC100490847
gene id: 8364:LOC100490847
uniprot id: A0A8J0QTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:LOC100489149
gene id: 8364:LOC100489149
uniprot id: A0A6I8QMA7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:ppil6
gene id: 8364:ppil6
uniprot id: A0A803K8A7
uniprot id: A0A8J1JKQ3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:LOC100489207
gene id: 8364:LOC100489207
uniprot id: A0A8J0SUP0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:slc4a4
gene id: 8364:slc4a4
uniprot id: A0A5S6NCY2
uniprot id: A0A6I8RQN0
uniprot id: A0A6I8RV91
uniprot id: A0A8J1JMR1
uniprot id: A0A8J1JQ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

8364:phf21a
gene id: 8364:phf21a
uniprot id: F6RLV2
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:chuk
gene id: 8364:chuk
uniprot id: B1H186
uniprot id: Q28DZ1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated when phosphorylated and inactivated when dephosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

8364:LOC100497290
gene id: 8364:LOC100497290
uniprot id: A0A1B8Y8U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:clk1
gene id: 8364:clk1
uniprot id: A0A6I8SV34
uniprot id: Q28EQ6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC108646290
gene id: 8364:LOC108646290
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:dnajb14
gene id: 8364:dnajb14
uniprot id: Q28I38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining hspa8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of hspa8/Hsc70: together with dnajb12, acts as a chaperone that promotes maturation of potassium channels by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on hspa8/Hsc70, the process of oligomerization of channel subunits is independent of hspa8/Hsc70.
messages: Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
messages: Endoplasmic reticulum membrane

8364:LOC100485409
gene id: 8364:LOC100485409
uniprot id: A0A8J0SMY3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC108648105
gene id: 8364:LOC108648105
uniprot id: A0A8J0T4T6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:mmab
gene id: 8364:mmab
uniprot id: A0A6I8STN2
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

8364:LOC116409577
gene id: 8364:LOC116409577
uniprot id: A0A8J1J8G8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105945457
gene id: 8364:LOC105945457
uniprot id: A0A6I8QBQ4
names: Similarity
messages: Belongs to the acid ceramidase family.

8364:anp32a
gene id: 8364:anp32a
uniprot id: Q28CW9
names: Similarity
messages: Belongs to the ANP32 family.

8364:apcs.2
gene id: 8364:apcs.2
uniprot id: A0A803JNX1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:polr1b
gene id: 8364:polr1b
uniprot id: F6ZV36
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

8364:hccs
gene id: 8364:hccs
uniprot id: A0A803J608
uniprot id: A0A8J0QEM4
uniprot id: F6T2R4
uniprot id: Q6DJ96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

8364:LOC100493356
gene id: 8364:LOC100493356
uniprot id: A0A6I8QGV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

8364:cct8
gene id: 8364:cct8
uniprot id: A0A6I8Q6A7
uniprot id: Q68ER1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

8364:slc25a30
gene id: 8364:slc25a30
uniprot id: Q5XGI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Probable transporter.

8364:hacd2
gene id: 8364:hacd2
uniprot id: B5DE06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC100497503
gene id: 8364:LOC100497503
uniprot id: F6YP15
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC100488564
gene id: 8364:LOC100488564
uniprot id: A0A6I8RX92
uniprot id: A0A8J1IZT8
uniprot id: A0A8J1IZU2
uniprot id: A0A8J1IZU3
uniprot id: A0A8J1IZV7
uniprot id: A0A8J1IZW3
uniprot id: A0A8J1J270
uniprot id: A0A8J1J344
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

8364:gipc3
gene id: 8364:gipc3
uniprot id: A4QNB3
names: Similarity
messages: Belongs to the GIPC family.

8364:sstr3
gene id: 8364:sstr3
uniprot id: A0A803K7R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ell
gene id: 8364:ell
uniprot id: A0A6I8RJ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

8364:ube2z
gene id: 8364:ube2z
uniprot id: Q66KB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in apoptosis regulation.
messages: Cytoplasm
messages: Nucleus

8364:LOC100486129
gene id: 8364:LOC100486129
uniprot id: A0A8J0R3J1
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

8364:jund
gene id: 8364:jund
uniprot id: A0A8J0QR43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

8364:cacnb3
gene id: 8364:cacnb3
uniprot id: A0A6I8RK79
uniprot id: A0A8J0SDP2
uniprot id: B0JZD2
names: Subcellular Location Annotation
messages: Cytoplasm

8364:ggnbp2
gene id: 8364:ggnbp2
uniprot id: A0A8J0SGW9
uniprot id: Q6DFP9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.

8364:alpi.1
gene id: 8364:alpi.1
uniprot id: A0A6I8RNA4
uniprot id: A0A8J1JNP1
uniprot id: F7E932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

8364:slc25a22
gene id: 8364:slc25a22
uniprot id: A0A803K9G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:rpl19
gene id: 8364:rpl19
uniprot id: Q6AZL5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Component of the large ribosomal subunit.

8364:krt6b
gene id: 8364:krt6b
uniprot id: A0A803K2V3
names: Similarity
messages: Belongs to the intermediate filament family.

8364:LOC100488200
gene id: 8364:LOC100488200
uniprot id: A0A6I8T2H8
uniprot id: A0A8J1JIH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

8364:LOC105945888
gene id: 8364:LOC105945888
uniprot id: A0A8J0SDJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:tp53i11
gene id: 8364:tp53i11
uniprot id: A8E5W1
names: Subcellular Location Annotation
messages: Membrane

8364:pex1
gene id: 8364:pex1
uniprot id: A0A6I8Q6G4
uniprot id: F6SHU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

8364:gpbp1
gene id: 8364:gpbp1
uniprot id: Q28FE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Functions as a GC-rich promoter-specific transactivating transcription factor.
messages: Nucleus

8364:cilp2
gene id: 8364:cilp2
uniprot id: A0A6I8SK43
names: Subcellular Location Annotation
messages: extracellular matrix

8364:rtf2
gene id: 8364:rtf2
uniprot id: A0A1B8Y5J8
uniprot id: Q6NVS6
names: Similarity
messages: Belongs to the rtf2 family.

8364:cldn23
gene id: 8364:cldn23
uniprot id: A0A803KA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8364:tbpl1
gene id: 8364:tbpl1
uniprot id: Q6DIY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Cytoplasm
messages: Nucleus
messages: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis. Particularly regulates genes that have a role in catabolism (By similarity).

8364:slc25a46
gene id: 8364:slc25a46
uniprot id: A0A8J1JCF2
uniprot id: A4IIC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.
messages: Membrane
messages: Mitochondrion outer membrane

8364:rps23
gene id: 8364:rps23
uniprot id: Q5HZT5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

8364:LOC100489387
gene id: 8364:LOC100489387
uniprot id: A0A8J1JFG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

8364:cfl1
gene id: 8364:cfl1
uniprot id: Q6NX11
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Inactive when phosphorylated. Phosphorylation levels vary during development. Dephosphorylated by pdxp (By similarity).
messages: May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Required for formation of the cleavage furrow during cytokinesis.
messages: Membrane
messages: Nucleus matrix
messages: cell cortex
messages: cytoskeleton

8364:prom1
gene id: 8364:prom1
uniprot id: A0A8J1JI96
uniprot id: A0A8J1JLC3
uniprot id: A0A8J1JMN9
uniprot id: A0A8J1JQX2
uniprot id: A0A8J1JRL1
uniprot id: A0A8J1JRS0
uniprot id: A0A8J1JSM3
uniprot id: E9LYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

8364:LOC100494987
gene id: 8364:LOC100494987
uniprot id: A0A8J1JC10
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:LOC100497899
gene id: 8364:LOC100497899
uniprot id: A0A8J1JR01
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:il4r
gene id: 8364:il4r
uniprot id: A0A6I8S2C9
uniprot id: A0A8J1IU58
names: Subcellular Location Annotation
messages: Membrane

8364:ccdc65
gene id: 8364:ccdc65
uniprot id: F6X3T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC1 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum axoneme

8364:LOC108645662
gene id: 8364:LOC108645662
uniprot id: A0A8J0SY21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100498622
gene id: 8364:LOC100498622
uniprot id: A0A6I8Q0P3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:casc1
gene id: 8364:casc1
uniprot id: A0A803J618
names: Similarity
messages: Belongs to the DNAI7 family.

8364:sirt2
gene id: 8364:sirt2
uniprot id: A0A8J0QND7
uniprot id: A0A8J0QZE9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

8364:mreg
gene id: 8364:mreg
uniprot id: F7D1N3
uniprot id: Q0P4L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the melanoregulin family.
messages: Cytoplasmic vesicle membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate.

8364:hdac9
gene id: 8364:hdac9
uniprot id: A0A6I8QB69
uniprot id: A0A8J0QM17
uniprot id: A0A8J0R4C9
uniprot id: A0A8J1JRK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus

8364:LOC116406440
gene id: 8364:LOC116406440
uniprot id: A0A8J1JUG3
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100486030
gene id: 8364:LOC100486030
uniprot id: A0A8J0QMJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Membrane

8364:wdr45
gene id: 8364:wdr45
uniprot id: A0A8J1J1R3
uniprot id: F6ZQU8
uniprot id: Q5M8E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure

8364:LOC116410834
gene id: 8364:LOC116410834
uniprot id: A0A8J1JJ00
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:atl2
gene id: 8364:atl2
uniprot id: A0A8J0QU64
uniprot id: A0A8J0R3R1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:LOC116412157
gene id: 8364:LOC116412157
uniprot id: A0A8J1JYP4
names: Subcellular Location Annotation
messages: Membrane

8364:mad1l1
gene id: 8364:mad1l1
uniprot id: A0A6I8Q8D1
uniprot id: A0A6I8SZD1
uniprot id: A0A8J1IS96
uniprot id: Q6DEZ6
names: Similarity
messages: Belongs to the MAD1 family.

8364:cdkn1b
gene id: 8364:cdkn1b
uniprot id: A0A803JZK6
names: Similarity
messages: Belongs to the CDI family.

8364:agap2
gene id: 8364:agap2
uniprot id: A0A6I8Q4S2
uniprot id: A0A6I8QJ11
uniprot id: A0A8J0SGZ2
uniprot id: F7ALV8
names: Similarity
messages: Belongs to the centaurin gamma-like family.

8364:cyb5r2
gene id: 8364:cyb5r2
uniprot id: A0A8J0SBZ5
uniprot id: Q5BJ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Membrane
messages: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis and drug metabolism.

8364:bcr
gene id: 8364:bcr
uniprot id: F6VE66
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

8364:dock6
gene id: 8364:dock6
uniprot id: A0A6I8Q2Z7
uniprot id: A0A6I8RE34
uniprot id: A0A803K2J6
uniprot id: A0A8J1JBP0
names: Similarity
messages: Belongs to the DOCK family.

8364:qtrt1
gene id: 8364:qtrt1
uniprot id: Q28HC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit qtrt1 and an accessory subunit qtrt2.
messages: Mitochondrion outer membrane

8364:insm2
gene id: 8364:insm2
uniprot id: A0A8J0QMT8
names: Subcellular Location Annotation
messages: Nucleus

8364:cyp26c1
gene id: 8364:cyp26c1
uniprot id: F7AXB0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:pnpla1
gene id: 8364:pnpla1
uniprot id: A0A8J1J451
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:or4e2
gene id: 8364:or4e2
uniprot id: A0A8J1IZE3
names: Subcellular Location Annotation
messages: Membrane

8364:exosc9
gene id: 8364:exosc9
uniprot id: B1H0X8
names: Subcellular Location Annotation
messages: Cytoplasm

8364:gja5
gene id: 8364:gja5
uniprot id: A0A803JXB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:col4a5
gene id: 8364:col4a5
uniprot id: A0A6I8QYG5
uniprot id: A0A6I8SI48
uniprot id: A0A7D9NK48
uniprot id: A0A8J0R3V1
uniprot id: A0A8J0R6B6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

8364:foxo3
gene id: 8364:foxo3
uniprot id: F7DZ24
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100492347
gene id: 8364:LOC100492347
uniprot id: A0A8J1J8G1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pou5f3.3
gene id: 8364:pou5f3.3
uniprot id: B3DM23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Interacts with the transcription factors tcf7l1/tcf3 and vegt.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription, probably by forming a transcriptional repression complex on the promoters of target genes. Binds to an octamer motif in interspersed RNA (By similarity).

8364:aldh18a1
gene id: 8364:aldh18a1
uniprot id: A0A8J0SV77
uniprot id: A0A8J0T4A6
uniprot id: A0A8J0T4B1
uniprot id: A0A8J0T4L7
uniprot id: A0A8J0T5E7
uniprot id: F6X772
uniprot id: Q28DF8
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

8364:vdac2
gene id: 8364:vdac2
uniprot id: Q07G51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Mitochondrion outer membrane

8364:actn1
gene id: 8364:actn1
uniprot id: A0A8J0SLD9
uniprot id: A0A8J0STJ6
uniprot id: F7B6G0
uniprot id: F7BWV7
uniprot id: Q05AR8
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Belongs to the alpha-actinin family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

8364:LOC100498128
gene id: 8364:LOC100498128
uniprot id: F6SNC8
names: Similarity
messages: Belongs to the cyclin-dependent kinase 5 activator family.

8364:cacna2d2
gene id: 8364:cacna2d2
uniprot id: A0A6I8S0M4
uniprot id: F7C1C8
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

8364:rasgrp1
gene id: 8364:rasgrp1
uniprot id: A0A6I8PW37
uniprot id: A0A8J0SUK8
names: Similarity
messages: Belongs to the RASGRP family.

8364:usp39
gene id: 8364:usp39
uniprot id: A0A6I8QIU1
names: Subcellular Location Annotation
messages: Nucleus

8364:tmem63b
gene id: 8364:tmem63b
uniprot id: A0A803JNU3
uniprot id: A0A803JS56
uniprot id: A0A8J1JLL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

8364:hspb3
gene id: 8364:hspb3
uniprot id: A0A8J0QWZ6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:c19orf25
gene id: 8364:c19orf25
uniprot id: A0A8J1JGW5
uniprot id: Q28C26
names: Similarity
messages: Belongs to the UPF0449 family.

8364:cmc1
gene id: 8364:cmc1
uniprot id: A9UMU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

8364:LOC100489750
gene id: 8364:LOC100489750
uniprot id: A0A8J1IQP3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:ppfia2
gene id: 8364:ppfia2
uniprot id: A0A6I8RN55
uniprot id: A0A6I8SQH0
uniprot id: A0A8J1JA53
uniprot id: A0A8J1JA55
uniprot id: A0A8J1JDN8
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

8364:LOC100486140
gene id: 8364:LOC100486140
uniprot id: A0A8J0QRS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:jmjd7-pla2g4b
gene id: 8364:jmjd7-pla2g4b
uniprot id: A0A8J1IS45
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

8364:kcnj1
gene id: 8364:kcnj1
uniprot id: A0A803JTM6
uniprot id: F7E8U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:pigu
gene id: 8364:pigu
uniprot id: A0A8J0SZK9
uniprot id: Q28CK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:trub1
gene id: 8364:trub1
uniprot id: A0A803J5Q4
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

8364:creld1
gene id: 8364:creld1
uniprot id: A0A6I8RMG7
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116412372
gene id: 8364:LOC116412372
uniprot id: A0A8J1K120
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100497097
gene id: 8364:LOC100497097
uniprot id: A0A8J0R1A0
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

8364:ndor1
gene id: 8364:ndor1
uniprot id: B1H2T7
uniprot id: F7DMQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.
messages: perinuclear region

8364:LOC100498433
gene id: 8364:LOC100498433
uniprot id: A0A803KA71
uniprot id: A0A8J1J4J5
uniprot id: A0A8J1J7Z4
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

8364:LOC105948322
gene id: 8364:LOC105948322
uniprot id: A0A6I8RUR5
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:ablim2
gene id: 8364:ablim2
uniprot id: A0A6I8QP32
uniprot id: A0A6I8S454
uniprot id: A0A8J1IZZ9
uniprot id: A0A8J1J003
uniprot id: A0A8J1J004
uniprot id: A0A8J1J008
uniprot id: A0A8J1J013
uniprot id: A0A8J1J022
uniprot id: A0A8J1J027
uniprot id: A0A8J1J2D2
uniprot id: A0A8J1J3A0
uniprot id: A0A8J1J3A5
uniprot id: A0A8J1J3B0
names: Subcellular Location Annotation
messages: Cytoplasm

8364:pllp
gene id: 8364:pllp
uniprot id: F7ENT9
names: Subcellular Location Annotation
messages: Membrane

8364:mical3
gene id: 8364:mical3
uniprot id: A0A8J0S9Y4
uniprot id: A0A8J0SHT5
uniprot id: A0A8J0SHU0
uniprot id: A0A8J0SJ23
uniprot id: A0A8J0SJ28
uniprot id: A0A8J1J989
uniprot id: A0A8J1J993
uniprot id: A0A8J1J994
uniprot id: A0A8J1J995
uniprot id: A0A8J1J998
uniprot id: A0A8J1J9A0
uniprot id: A0A8J1J9A1
uniprot id: A0A8J1J9A3
uniprot id: A0A8J1J9A4
uniprot id: A0A8J1J9A7
uniprot id: A0A8J1JBP7
uniprot id: A0A8J1JBQ3
uniprot id: A0A8J1JBQ8
uniprot id: A0A8J1JBR2
uniprot id: A0A8J1JCS5
uniprot id: A0A8J1JCT0
uniprot id: A0A8J1JCT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm
messages: Nucleus
messages: cytoskeleton

8364:LOC101733166
gene id: 8364:LOC101733166
uniprot id: A0A8J1IWL3
names: Subcellular Location Annotation
messages: Nucleus

8364:b3galnt2
gene id: 8364:b3galnt2
uniprot id: Q5M900
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (dag1) glycosylation (By similarity).
messages: Endoplasmic reticulum
messages: Golgi apparatus membrane

8364:LOC101731959
gene id: 8364:LOC101731959
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:astl2g
gene id: 8364:astl2g
uniprot id: F6ZRI3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:hnrnph1
gene id: 8364:hnrnph1
uniprot id: Q6GL26
names: Subcellular Location Annotation
messages: nucleoplasm

8364:LOC100489228
gene id: 8364:LOC100489228
uniprot id: A0A8J0QY37
names: Subcellular Location Annotation
messages: Membrane

8364:fgd4
gene id: 8364:fgd4
uniprot id: A0A803JF58
uniprot id: A0A8J1JCJ8
names: Subcellular Location Annotation
messages: cytoskeleton

8364:LOC100491908
gene id: 8364:LOC100491908
uniprot id: A0A8J1IPA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

8364:shank3
gene id: 8364:shank3
uniprot id: A0A6I8RN81
uniprot id: A0A8J0SAK7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynaptic density

8364:MGC107884
gene id: 8364:MGC107884
uniprot id: Q5FW19
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:ap5m1
gene id: 8364:ap5m1
uniprot id: A0A803KKA5
uniprot id: A9ULI2
uniprot id: F6UVT5
names: Subcellular Location Annotation
names: Subunit
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

8364:aadac
gene id: 8364:aadac
uniprot id: Q6DIR7
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

8364:LOC101731405
gene id: 8364:LOC101731405
uniprot id: A0A8J1JTK3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:vldlr
gene id: 8364:vldlr
uniprot id: A0A8J0QL29
uniprot id: A0A8J0QZY3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: clathrin-coated pit

8364:LOC101731882
gene id: 8364:LOC101731882
uniprot id: A0A8J0R156
uniprot id: A0A8J0R389
names: Similarity
messages: Belongs to the FAM154 family.

8364:col18a1
gene id: 8364:col18a1
uniprot id: A0A8J0SNX2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100497082
gene id: 8364:LOC100497082
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:brinp3
gene id: 8364:brinp3
uniprot id: A0A7D9NLR3
names: Similarity
messages: Belongs to the BRINP family.

8364:pla2g12a
gene id: 8364:pla2g12a
uniprot id: Q28GM9
names: Subcellular Location Annotation
messages: Secreted

8364:fam72a
gene id: 8364:fam72a
uniprot id: A0A8J0SMQ6
uniprot id: Q28GM7
names: Similarity
messages: Belongs to the FAM72 family.

8364:LOC101733642
gene id: 8364:LOC101733642
uniprot id: A0A8J1IUX6
uniprot id: A0A8J1IY27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:ctsb
gene id: 8364:ctsb
uniprot id: Q6P4K2
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:u2af2
gene id: 8364:u2af2
uniprot id: Q28EQ0
uniprot id: Q6NVN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

8364:LOC101733694
gene id: 8364:LOC101733694
uniprot id: A0A8J0SZZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:sec61a1
gene id: 8364:sec61a1
uniprot id: Q6GLE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:srsf2
gene id: 8364:srsf2
uniprot id: Q6P366
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

8364:adamts13
gene id: 8364:adamts13
uniprot id: A0A8J1IPA3
uniprot id: A0A8J1IPA5
uniprot id: A0A8J1IPA6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:alyref
gene id: 8364:alyref
uniprot id: Q28FB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.
messages: Belongs to the ALYREF family.
messages: Component of the transcription/export (TREX) complex; TREX seems to have a dynamic structure involving ATP-dependent remodeling (By similarity).
messages: Cytoplasm
messages: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. Involved in the nuclear export of intronless mRNA. Involved in transcription elongation and genome stability (By similarity).
messages: Nucleus
messages: Nucleus speckle

8364:ciao3
gene id: 8364:ciao3
uniprot id: A8WH18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NARF family.
messages: Component of the CIA complex.
messages: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins.

8364:gpr61
gene id: 8364:gpr61
uniprot id: A0A803JJ13
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:lhfpl6
gene id: 8364:lhfpl6
uniprot id: F6S322
names: Subcellular Location Annotation
messages: Membrane

8364:thap11
gene id: 8364:thap11
uniprot id: A4IGQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP11 family.
messages: Nucleus
messages: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).

8364:cenpx
gene id: 8364:cenpx
uniprot id: A0A8J0QYC8
uniprot id: A0A8J0R783
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

8364:dstyk
gene id: 8364:dstyk
uniprot id: Q67E00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. May play a role in the embryonic development.

8364:pcyt1b
gene id: 8364:pcyt1b
uniprot id: A0A8J0QKA3
uniprot id: A0A8J0R1E2
uniprot id: F6Z6M3
uniprot id: F7DFG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
messages: Membrane

8364:hmgcr
gene id: 8364:hmgcr
uniprot id: F6WAG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

8364:mtmr9
gene id: 8364:mtmr9
uniprot id: Q0P4T7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:sdc4
gene id: 8364:sdc4
uniprot id: B0BM67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Membrane

8364:gch1
gene id: 8364:gch1
uniprot id: F7AIS0
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

8364:cetp
gene id: 8364:cetp
uniprot id: A0A6I8SWA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.
messages: Secreted

8364:proz
gene id: 8364:proz
uniprot id: A0A6I8PTX3
uniprot id: B1H1C8
uniprot id: Q5M8E7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:anxa10
gene id: 8364:anxa10
uniprot id: A4QNM7
names: Similarity
messages: Belongs to the annexin family.

8364:tubgcp6
gene id: 8364:tubgcp6
uniprot id: A0A8J1J681
uniprot id: F6ZI03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: centrosome

8364:avpr2.2
gene id: 8364:avpr2.2
uniprot id: A0A6I8QG78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:ccdc93
gene id: 8364:ccdc93
uniprot id: Q640U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC93 family.
messages: Early endosome
messages: May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery.

8364:abo.3
gene id: 8364:abo.3
uniprot id: A0A6I8SLB0
uniprot id: B5DED0
uniprot id: Q28IV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

8364:p4ha1
gene id: 8364:p4ha1
uniprot id: A0A8J1JVQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8364:nxph3
gene id: 8364:nxph3
uniprot id: A4IJ01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

8364:sox2
gene id: 8364:sox2
uniprot id: Q6NVN0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activator. Functions as a switch in neuronal development, participating in the differentiation of embryonic neuroectodermal cells into neural tissues by making the ectodermal cells responsive to FGF-neuralizing signals (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).

8364:LOC100485902
gene id: 8364:LOC100485902
uniprot id: A0A8J1IY23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sppl2a
gene id: 8364:sppl2a
uniprot id: A9JRJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

8364:mrpl22
gene id: 8364:mrpl22
uniprot id: A0A803K3D4
uniprot id: Q0VFH6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

8364:sirt5
gene id: 8364:sirt5
uniprot id: F7DKV7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-101 and Arg-104) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
messages: Nucleus
messages: cytosol

8364:man2b2
gene id: 8364:man2b2
uniprot id: A0A8J0SNH8
uniprot id: A8WGI3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

8364:wnt7c
gene id: 8364:wnt7c
uniprot id: A0A6I8QCH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:cd164
gene id: 8364:cd164
uniprot id: A0A5S6MNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

8364:calhm2
gene id: 8364:calhm2
uniprot id: F7AP77
uniprot id: Q6P4X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

8364:slc17a7
gene id: 8364:slc17a7
uniprot id: Q05B21
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
messages: Cell membrane
messages: Chloride channel activity is allosterically activated by lumenal H(+) and Cl(-) leading to synaptic vesicles acidification. The L-glutamate transport activity is allosterically activated by lumenal H(+) and Cl(-). The allosteric activation by H(+) efficiently prevents non-vesicular efflux across the plasma membrane, thereby restricting L-glutamate transport activity to acidic membranes such as synaptic vesicles.
messages: Martineau M. et al. show that may function as a L-glutamate/H(+) antiporter (By similarity). However, according to Eriksen J. et al., H(+) is an allosteric activator (By similarity).
messages: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake. The vesicular K(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity).
messages: synaptic vesicle membrane
messages: synaptosome

8364:LOC100494762
gene id: 8364:LOC100494762
uniprot id: A0A803K5Y8
uniprot id: F7CU05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:scara5
gene id: 8364:scara5
uniprot id: A0A6I8Q338
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.
messages: Homotrimer.
messages: Membrane

8364:hivep3
gene id: 8364:hivep3
uniprot id: F7D5N2
names: Subcellular Location Annotation
messages: Nucleus

8364:proser1
gene id: 8364:proser1
uniprot id: F6X3H9
uniprot id: F7D944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC43 family.
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

8364:gfra2
gene id: 8364:gfra2
uniprot id: F7BSL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane

8364:ssr4
gene id: 8364:ssr4
uniprot id: A0A8J0QR25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

8364:cdk1
gene id: 8364:cdk1
uniprot id: Q6P7L3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:ndufb6
gene id: 8364:ndufb6
uniprot id: Q28HL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8364:pgap6
gene id: 8364:pgap6
uniprot id: A0A7D9N0F2
uniprot id: A0A803K629
uniprot id: A0A8J0R7F4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:sgms1
gene id: 8364:sgms1
uniprot id: F6UTK5
uniprot id: L7N2Q0
uniprot id: Q640R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

8364:glmp
gene id: 8364:glmp
uniprot id: A0A803K3E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLMP family.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

8364:chpf
gene id: 8364:chpf
uniprot id: A0A803K2L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

8364:enpp3
gene id: 8364:enpp3
uniprot id: F7CHX8
names: Subcellular Location Annotation
messages: Secreted

8364:cdh15
gene id: 8364:cdh15
uniprot id: A0A6I8S5C1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8364:rps21
gene id: 8364:rps21
uniprot id: Q6DDC6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

8364:tlr1
gene id: 8364:tlr1
uniprot id: A0A8J0T487
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8364:LOC100485637
gene id: 8364:LOC100485637
uniprot id: A0A6I8SD69
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:ugt2b4
gene id: 8364:ugt2b4
uniprot id: A0A8J0QRV7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:dars1
gene id: 8364:dars1
uniprot id: A0A803KHA2
uniprot id: A0A8J0SN76
uniprot id: F7AWV1
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

8364:mmp3
gene id: 8364:mmp3
uniprot id: F6UAM2
uniprot id: Q28J86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Secreted

8364:pcsk2
gene id: 8364:pcsk2
uniprot id: A0JP87
names: Similarity
messages: Belongs to the peptidase S8 family.

8364:pkn1
gene id: 8364:pkn1
uniprot id: A0A6I8Q1W9
uniprot id: A0A6I8QV80
uniprot id: A0A8J0R3Y2
uniprot id: A0A8J0S9X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

8364:isx
gene id: 8364:isx
uniprot id: A0A803K280
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100491833
gene id: 8364:LOC100491833
uniprot id: A0A8J1IPX4
names: Subcellular Location Annotation
messages: Membrane

8364:psd3
gene id: 8364:psd3
uniprot id: A0A8J0QN33
uniprot id: A0A8J0S6D7
uniprot id: A0A8J1JQ85
uniprot id: A0A8J1JQ87
names: Subcellular Location Annotation
messages: ruffle membrane

8364:slc33a1
gene id: 8364:slc33a1
uniprot id: F6Z7F4
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100496443
gene id: 8364:LOC100496443
uniprot id: A0A8J0SLH9
uniprot id: F6VXI6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:slc44a4
gene id: 8364:slc44a4
uniprot id: A0A6I8STK1
uniprot id: F6ZYW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

8364:btg4
gene id: 8364:btg4
uniprot id: Q28GL0
names: Similarity
messages: Belongs to the BTG family.

8364:znf330
gene id: 8364:znf330
uniprot id: Q6DEX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

8364:rad9a
gene id: 8364:rad9a
uniprot id: A0A803K8M5
uniprot id: Q6DJ26
names: Similarity
messages: Belongs to the rad9 family.

8364:lrp6
gene id: 8364:lrp6
uniprot id: A0A6I8SHK9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:e2f8
gene id: 8364:e2f8
uniprot id: A0A1B8Y1F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8364:lyn
gene id: 8364:lyn
uniprot id: A0A6I8S4I8
uniprot id: Q28IV0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8364:mrps31
gene id: 8364:mrps31
uniprot id: A0A8J0R1P5
uniprot id: Q0V9E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

8364:fam122b
gene id: 8364:fam122b
uniprot id: Q28D59
names: Similarity
messages: Belongs to the FAM122 family.

8364:crygdl.48
gene id: 8364:crygdl.48
uniprot id: Q6DER7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:cactin
gene id: 8364:cactin
uniprot id: A0A7D9NL66
names: Similarity
messages: Belongs to the CACTIN family.

8364:tmem120b
gene id: 8364:tmem120b
uniprot id: Q63ZG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Necessary for efficient adipogenesis. Does not show ion channel activity.
messages: Nucleus inner membrane

8364:LOC116408398
gene id: 8364:LOC116408398
uniprot id: A0A8J1IZM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:phf8
gene id: 8364:phf8
uniprot id: F6Y9Q4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

8364:lhcgr
gene id: 8364:lhcgr
uniprot id: A0A803JFS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

8364:trappc5
gene id: 8364:trappc5
uniprot id: Q28C11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

8364:abhd2
gene id: 8364:abhd2
uniprot id: B4F6T5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

8364:dync1li2
gene id: 8364:dync1li2
uniprot id: A0A8J0QIZ0
uniprot id: A0A8J0R393
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

8364:LOC100486672
gene id: 8364:LOC100486672
uniprot id: A0A803K4P0
uniprot id: F6VHQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Belongs to the histone H2A family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Chromosome
messages: Nucleus
messages: Peroxisome membrane
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC100493823
gene id: 8364:LOC100493823
uniprot id: A0A8J0QSS6
names: Similarity
messages: Belongs to the hexokinase family.

8364:slc4a3
gene id: 8364:slc4a3
uniprot id: A0A1B8Y266
uniprot id: A0A7D9NL51
uniprot id: F6WHI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

8364:madd
gene id: 8364:madd
uniprot id: A0A6I8S7G7
uniprot id: A0A6I8SJU5
uniprot id: A0A8J0SC87
uniprot id: A0A8J0SC92
uniprot id: A0A8J0SC99
uniprot id: A0A8J0SJ27
uniprot id: A0A8J0SJ37
uniprot id: A0A8J0SJ42
uniprot id: A0A8J0SJ48
uniprot id: A0A8J0SKL0
uniprot id: A0A8J0SKL4
uniprot id: A0A8J0SKL9
uniprot id: A0A8J0SKM3
uniprot id: A0A8J0SKM8
uniprot id: A0A8J0SLV6
uniprot id: A0A8J0SLW1
uniprot id: A0A8J0SLW6
uniprot id: A0A8J0SLX0
uniprot id: A0A8J0SLY2
uniprot id: A0A8J0SLY7
uniprot id: A0A8J0SLZ7
uniprot id: A0A8J0SM02
uniprot id: A0A8J0T038
uniprot id: A0A8J1JDY9
uniprot id: A0A8J1JDZ2
uniprot id: A0A8J1JDZ4
uniprot id: A0A8J1JDZ5
uniprot id: A0A8J1JDZ7
uniprot id: A0A8J1JDZ9
uniprot id: A0A8J1JE01
uniprot id: A0A8J1JE02
uniprot id: A0A8J1JE04
uniprot id: A0A8J1JE06
uniprot id: A0A8J1JE07
uniprot id: A0A8J1JE09
uniprot id: A0A8J1JE11
uniprot id: A0A8J1JE12
uniprot id: A0A8J1JE15
uniprot id: A0A8J1JE20
uniprot id: A0A8J1JGG1
uniprot id: A0A8J1JGG6
uniprot id: A0A8J1JGH1
uniprot id: A0A8J1JGH6
uniprot id: A0A8J1JGI3
uniprot id: A0A8J1JHH4
uniprot id: A0A8J1JHH9
uniprot id: A0A8J1JHI2
uniprot id: A0A8J1JHI7
uniprot id: A0A8J1JHJ4
uniprot id: A0JLZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8364:tbccd1
gene id: 8364:tbccd1
uniprot id: A1L0Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: May play a role in the regulation of centrosome and Golgi apparatus positioning.
messages: centrosome
messages: spindle pole

8364:rnf111
gene id: 8364:rnf111
uniprot id: A0A6I8PTY2
uniprot id: A0A6I8QUU3
uniprot id: A0A6I8S7Z8
uniprot id: A0A8J0SNP5
uniprot id: A0A8J0SXM0
uniprot id: Q0V9R0
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Arkadia family.
messages: Binds free ubiquitin non-covalently via its RING-type zinc finger. Ubiquitin-binding leads to enhance the E3 ubiquitin-protein ligase activity by stabilizing the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and activating ubiquitin transfer.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
messages: Monomer.
messages: Nucleus
messages: PML body
messages: The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin (By similarity). Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the 'closed' conformation and stimulates ubiquitin transfer (By similarity).
messages: The SUMO interaction motifs (SIMs) mediates the binding to polysumoylated substrate.

8364:LOC100492011
gene id: 8364:LOC100492011
uniprot id: A0A8J0SW54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:syvn1
gene id: 8364:syvn1
uniprot id: A0A6I8PX52
uniprot id: A0A8J0QDB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRD1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:cand1
gene id: 8364:cand1
uniprot id: F6WMJ5
names: Similarity
messages: Belongs to the CAND family.

8364:LOC116408757
gene id: 8364:LOC116408757
uniprot id: A0A8J1J5Z7
names: Subcellular Location Annotation
messages: Membrane

8364:rrp12
gene id: 8364:rrp12
uniprot id: A0A6I8RE83
uniprot id: A2VCY8
names: Similarity
messages: Belongs to the RRP12 family.

8364:brcc3
gene id: 8364:brcc3
uniprot id: Q4VA72
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the BRCA1-A complex, at least composed of brca1, bard1, uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and babam1/nba1. In the BRCA1-A complex, interacts directly with abraxas1 and babam2. Component of the BRISC complex, at least composed of abraxas2, brcc3/brcc36, babam2 and babam1/nba1. Within the complex, interacts directly with abraxas2. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin (By similarity).
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the rnf8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.
messages: Nucleus
messages: spindle pole

8364:nr0b2
gene id: 8364:nr0b2
uniprot id: F7DXD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

8364:rbbp7
gene id: 8364:rbbp7
uniprot id: Q6P315
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin.
messages: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.
messages: Nucleus

8364:slc25a23
gene id: 8364:slc25a23
uniprot id: A0A8J0T260
uniprot id: B5DE17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

8364:lzic
gene id: 8364:lzic
uniprot id: A0A8J0T282
uniprot id: Q28D79
names: Similarity
messages: Belongs to the CTNNBIP1 family.

8364:LOC101731378
gene id: 8364:LOC101731378
uniprot id: A0A8J1IYB3
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:snx1
gene id: 8364:snx1
uniprot id: A0A8J0QUH8
uniprot id: A0A8J1JAV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

8364:LOC116412163
gene id: 8364:LOC116412163
uniprot id: A0A8J1JX93
names: Subcellular Location Annotation
messages: Membrane

8364:erf
gene id: 8364:erf
uniprot id: Q5EB35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:LOC116412119
gene id: 8364:LOC116412119
uniprot id: A0A8J1JUL2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:cdca5
gene id: 8364:cdca5
uniprot id: F6Z346
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

8364:LOC116410963
gene id: 8364:LOC116410963
uniprot id: A0A8J1JL05
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

8364:dync1li1
gene id: 8364:dync1li1
uniprot id: A0A8J0SQ42
uniprot id: Q0V9Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

8364:fgf14
gene id: 8364:fgf14
uniprot id: A0A803KJT6
uniprot id: A0A8J0SR72
uniprot id: F7E816
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:slc35f4
gene id: 8364:slc35f4
uniprot id: A0A8J0QNS1
uniprot id: A0A8J0R2F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

8364:rdh8
gene id: 8364:rdh8
uniprot id: A0A803JBY6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:ripor1
gene id: 8364:ripor1
uniprot id: A0A6I8QWR6
uniprot id: A0A6I8SV35
uniprot id: A0A8J1JFC5
uniprot id: A0A8J1JIT7
names: Similarity
messages: Belongs to the RIPOR family.

8364:kif13b
gene id: 8364:kif13b
uniprot id: A0A8J1JM35
uniprot id: A0A8J1JM39
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:LOC116410917
gene id: 8364:LOC116410917
uniprot id: A0A8J1JMZ1
names: Subcellular Location Annotation
messages: Membrane

8364:upf3b
gene id: 8364:upf3b
uniprot id: A0A8J0QRY8
uniprot id: F6YH23
uniprot id: F7DUM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RENT3 family.
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

8364:tmem245
gene id: 8364:tmem245
uniprot id: A0A6I8QCA9
uniprot id: A0A6I8R479
uniprot id: A0A6I8RSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

8364:nudt7
gene id: 8364:nudt7
uniprot id: F6V6C1
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

8364:copb1
gene id: 8364:copb1
uniprot id: B5DEA8
uniprot id: F6QRM4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8364:hddc2
gene id: 8364:hddc2
uniprot id: A0A8J0QNN4
uniprot id: F6UN93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

8364:LOC108644702
gene id: 8364:LOC108644702
uniprot id: A0A8J0T0F7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101734657
gene id: 8364:LOC101734657
uniprot id: A0A8J1J8C7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:sh3bp5
gene id: 8364:sh3bp5
uniprot id: A0A803KIA7
uniprot id: F7AXW3
uniprot id: Q6P4N3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

8364:h2az1
gene id: 8364:h2az1
uniprot id: Q6DER6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Zl forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be required at gastrulation for correct mesoderm formation (By similarity).

8364:sv2a
gene id: 8364:sv2a
uniprot id: F6QL25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

8364:st3gal4
gene id: 8364:st3gal4
uniprot id: Q28CN5
uniprot id: Q703F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:tafa1
gene id: 8364:tafa1
uniprot id: A0A803K8R5
uniprot id: A0A803KC50
names: Similarity
messages: Belongs to the TAFA family.

8364:trpc4
gene id: 8364:trpc4
uniprot id: F6V6Z5
names: Subcellular Location Annotation
messages: Membrane

8364:napb
gene id: 8364:napb
uniprot id: A0A8J0SLG9
uniprot id: Q05B34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

8364:cln8
gene id: 8364:cln8
uniprot id: A0A6I8RVA6
uniprot id: F7C3X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RHPN family.
messages: Membrane

8364:dpep2
gene id: 8364:dpep2
uniprot id: A0A803JL05
uniprot id: A0A8J1JFE3
uniprot id: F7EAM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

8364:mcm10
gene id: 8364:mcm10
uniprot id: A0A8J0S9L0
uniprot id: Q28E45
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).
messages: Belongs to the MCM10 family.
messages: Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.
messages: Nucleus
messages: Self-associates.
messages: The N-terminal domain mediates homodimerization.

8364:LOC116407591
gene id: 8364:LOC116407591
uniprot id: A0A8J1ITP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:fbxo25
gene id: 8364:fbxo25
uniprot id: A0A803JZI1
uniprot id: Q569D4
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC594909
gene id: 8364:LOC594909
uniprot id: A0A8J1JJ12
uniprot id: Q28EW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
messages: cytoskeleton

8364:ckm
gene id: 8364:ckm
uniprot id: Q6P347
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

8364:slc23a2
gene id: 8364:slc23a2
uniprot id: B0JZG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Cell membrane
messages: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.

8364:lmod3
gene id: 8364:lmod3
uniprot id: A0A8J1JDY5
uniprot id: F6VFX5
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

8364:btg3
gene id: 8364:btg3
uniprot id: F6VQW7
names: Similarity
messages: Belongs to the BTG family.

8364:ltc4s.2
gene id: 8364:ltc4s.2
uniprot id: F7DHS8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8364:myo18b
gene id: 8364:myo18b
uniprot id: A0A8J0SXQ3
uniprot id: A0A8J0T0W0
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cpd
gene id: 8364:cpd
uniprot id: A0A803JS61
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:nr1d1
gene id: 8364:nr1d1
uniprot id: A4IIE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:LOC100495521
gene id: 8364:LOC100495521
uniprot id: A0A8J0T2N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8364:mfsd14b
gene id: 8364:mfsd14b
uniprot id: Q5M7S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8364:adora3.1
gene id: 8364:adora3.1
uniprot id: A0A8J0QJG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

8364:gtf2h1
gene id: 8364:gtf2h1
uniprot id: A0A6I8QNH1
uniprot id: A0A6I8R3X9
uniprot id: Q6DIF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

8364:osbp
gene id: 8364:osbp
uniprot id: A0A8J1JTK2
names: Similarity
messages: Belongs to the OSBP family.

8364:rara
gene id: 8364:rara
uniprot id: A0A6I8R0K9
uniprot id: A0A803JBZ9
uniprot id: A0A803JQ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:tgm2
gene id: 8364:tgm2
uniprot id: B3DM72
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8364:hoxa9
gene id: 8364:hoxa9
uniprot id: F7D5I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8364:mocs2
gene id: 8364:mocs2
uniprot id: A0A8J1IZD0
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
messages: Belongs to the MoaD family. MOCS2A subfamily.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B).
messages: cytosol

8364:dlg5
gene id: 8364:dlg5
uniprot id: A0A6I8QNJ0
uniprot id: A0A8J0QT32
uniprot id: A0A8J1JV89
names: Subcellular Location Annotation
messages: Cytoplasm

8364:b9d2
gene id: 8364:b9d2
uniprot id: A0A8J0QV68
uniprot id: F7BVU9
names: Subcellular Location Annotation
messages: cilium basal body

8364:LOC448579
gene id: 8364:LOC448579
uniprot id: Q6DF30
names: Similarity
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homodimer.

8364:skap2
gene id: 8364:skap2
uniprot id: A9JTL9
names: Similarity
messages: Belongs to the SKAP family.

8364:slc2a9
gene id: 8364:slc2a9
uniprot id: A0A6I8S2W0
uniprot id: F6UC71
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:cyb5d1
gene id: 8364:cyb5d1
uniprot id: Q0IHR1
names: Similarity
messages: Belongs to the cytochrome b5 family.

8364:ggt5
gene id: 8364:ggt5
uniprot id: A0A8J0QLB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

8364:septin10
gene id: 8364:septin10
uniprot id: A0A8J0S7H7
uniprot id: Q5XGD3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8364:sult1a1
gene id: 8364:sult1a1
uniprot id: Q6P8G4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:lamtor1
gene id: 8364:lamtor1
uniprot id: Q6P2W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMTOR1 family.
messages: Cell membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. May play a role in late endosomes/lysosomes biogenesis and regulate both the recycling of receptors through endosomes and the MAPK signaling pathway. May be involved in cholesterol homeostasis. May also play a role in RHOA activation (By similarity). Involved in the control of embryonic stem cells differentiation; together with FLCN it is necessary to recruit and activate RRAGC/RagC and RRAGD/RagD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity).

8364:c1qtnf12
gene id: 8364:c1qtnf12
uniprot id: A4IH36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adipolin/erythroferrone family.
messages: Homomultimer; disulfide-linked.
messages: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue.
messages: Secreted

8364:smim15
gene id: 8364:smim15
uniprot id: A0A803J644
uniprot id: F7DEE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane
messages: Nucleus

8364:nkx6-3
gene id: 8364:nkx6-3
uniprot id: A0A6I8R8S8
names: Subcellular Location Annotation
messages: Nucleus

8364:wrn
gene id: 8364:wrn
uniprot id: A0A8J0S6B8
uniprot id: A0A8J0SAP3
uniprot id: A0A8J0SCH3
uniprot id: A0A8J1JQP3
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

8364:ipo8
gene id: 8364:ipo8
uniprot id: A0A8J1JBZ6
uniprot id: F6QR70
names: Subcellular Location Annotation
messages: Cytoplasm

8364:tenm4
gene id: 8364:tenm4
uniprot id: A0A8J1J0R2
uniprot id: A0A8J1J0R7
uniprot id: A0A8J1J0S5
uniprot id: A0A8J1J347
uniprot id: A6QL56
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC496665
gene id: 8364:LOC496665
uniprot id: A0A8J0PFP0
uniprot id: Q5M8X3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:ddo
gene id: 8364:ddo
uniprot id: A0A8J0QZH3
uniprot id: A0A8J0SET7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

8364:LOC100496280
gene id: 8364:LOC100496280
uniprot id: A0A6I8SZM6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:LOC100145027
gene id: 8364:LOC100145027
uniprot id: F6QM14
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8364:ddx39a
gene id: 8364:ddx39a
uniprot id: Q28EE7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:b3gnt2
gene id: 8364:b3gnt2
uniprot id: F7EIV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:rorb.2
gene id: 8364:rorb.2
uniprot id: A0A6I8SKC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:hpdl
gene id: 8364:hpdl
uniprot id: A0A803JRC4
uniprot id: B1WAT4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

8364:grhl2
gene id: 8364:grhl2
uniprot id: A0A8J1JMU8
uniprot id: A0A8J1JRJ3
uniprot id: Q5M7R9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. Grainyhead subfamily.
messages: GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxal lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development.
messages: Membrane
messages: Nucleus
messages: Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes.

8364:trpm7
gene id: 8364:trpm7
uniprot id: A0A6I8QS09
uniprot id: A0A8J0QVH9
uniprot id: A0A8J0SHY6
uniprot id: A0A8J0SJ72
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

8364:clrn2
gene id: 8364:clrn2
uniprot id: A0A6I8PS27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

8364:prickle1
gene id: 8364:prickle1
uniprot id: A0A6I8QKU1
uniprot id: F7CD23
uniprot id: Q28FG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Regulates the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Essential for gastrulation cell movements, cooperating with dvl2/dsh to activate jnk. Acts together with tes to control axial elongation (By similarity).
messages: Belongs to the prickle / espinas / testin family.
messages: Cell membrane
messages: Interacts with dvl2/dsh and mapk8/jnk1.
messages: Membrane

8364:LOC116407969
gene id: 8364:LOC116407969
uniprot id: A0A8J1IXN9
uniprot id: A0A8J1IXP0
uniprot id: A0A8J1IXP5
uniprot id: A0A8J1IXT7
uniprot id: A0A8J1J040
uniprot id: A0A8J1J0W2
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

8364:LOC100491388
gene id: 8364:LOC100491388
uniprot id: A0A8J1JR10
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:c16orf91
gene id: 8364:c16orf91
uniprot id: A8WGU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSMST1 family.
messages: Membrane

8364:isyna1
gene id: 8364:isyna1
uniprot id: B0BM05
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

8364:cd34
gene id: 8364:cd34
uniprot id: A0A8J0QUJ9
names: Subcellular Location Annotation
messages: Membrane

8364:alkbh5
gene id: 8364:alkbh5
uniprot id: Q66JG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkB family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing and export (By similarity).
messages: Monomer.
messages: Nucleus speckle

8364:mindy2
gene id: 8364:mindy2
uniprot id: A0A8J0QU02
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

8364:ogfod3
gene id: 8364:ogfod3
uniprot id: Q5XGE0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OGFOD3 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Membrane

8364:ppcs
gene id: 8364:ppcs
uniprot id: A0A8J0T295
uniprot id: Q0IHM6
names: Similarity
messages: Belongs to the PPC synthetase family.

8364:LOC100494316
gene id: 8364:LOC100494316
uniprot id: Q6DK82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:myo15b
gene id: 8364:myo15b
uniprot id: A0A6I8QQ07
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:rbx1
gene id: 8364:rbx1
uniprot id: A0A6I8S8I3
names: Similarity
messages: Belongs to the RING-box family.

8364:ssrp1
gene id: 8364:ssrp1
uniprot id: A0A6I8RRM8
uniprot id: Q6GLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

8364:ano10
gene id: 8364:ano10
uniprot id: A0A6I8Q0X6
uniprot id: A0A6I8SGA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:tff3.1
gene id: 8364:tff3.1
uniprot id: A0A7D9N0J2
names: Subcellular Location Annotation
messages: Secreted

8364:mlh3
gene id: 8364:mlh3
uniprot id: A0A803JQH8
uniprot id: A0A803KCQ3
uniprot id: A0A8J0QEP2
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

8364:LOC101732819
gene id: 8364:LOC101732819
uniprot id: A0A8J1IYX6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:gsg1l2
gene id: 8364:gsg1l2
uniprot id: A0A6I8QKX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

8364:myo7a
gene id: 8364:myo7a
uniprot id: A0A6I8Q804
uniprot id: A0A8J0R1M1
uniprot id: A0A8J0S8P6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:tppp3
gene id: 8364:tppp3
uniprot id: A4IIY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: Cytoplasm
messages: Regulator of microtubule dynamic that has microtubule bundling activity.
messages: cytoskeleton

8364:kcnj3
gene id: 8364:kcnj3
uniprot id: F6R882
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

8364:eif4e2
gene id: 8364:eif4e2
uniprot id: Q28F16
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

8364:LOC116406844
gene id: 8364:LOC116406844
uniprot id: A0A8J1IPZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:slc5a9
gene id: 8364:slc5a9
uniprot id: A0A6I8QAB7
uniprot id: A0A8J0QJQ3
uniprot id: A0A8J0SCJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8364:LOC116409624
gene id: 8364:LOC116409624
uniprot id: A0A8J1J8L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:eif4g1
gene id: 8364:eif4g1
uniprot id: A0A6I8SSX3
uniprot id: A0A6I8SXK0
uniprot id: F7CS15
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

8364:dtwd1
gene id: 8364:dtwd1
uniprot id: Q28I29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDD superfamily. DTWD1 family.
messages: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).
messages: Nucleus

8364:cacna1h
gene id: 8364:cacna1h
uniprot id: A0A8J1IT57
uniprot id: A0A8J1IT67
uniprot id: A0A8J1IVK2
names: Subcellular Location Annotation
messages: Membrane

8364:qki
gene id: 8364:qki
uniprot id: A0A8J0SDD3
uniprot id: A0A8J0SKC7
uniprot id: A0A8J0SLR0
uniprot id: A0A8J0SN07
uniprot id: A0A8J0SN43
uniprot id: A0A8J0SN48
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:gtf2a2
gene id: 8364:gtf2a2
uniprot id: Q6DEQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

8364:tgfb1i1
gene id: 8364:tgfb1i1
uniprot id: A0A8J0SXU9
uniprot id: F6YN28
names: Similarity
messages: Belongs to the paxillin family.

8364:LOC116409854
gene id: 8364:LOC116409854
uniprot id: A0A803J424
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:pdk1
gene id: 8364:pdk1
uniprot id: A0A6I8Q4J8
uniprot id: F6QN91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

8364:LOC100488194
gene id: 8364:LOC100488194
uniprot id: A0A8J0QJN2
names: Subcellular Location Annotation
messages: Membrane

8364:tsnare1
gene id: 8364:tsnare1
uniprot id: A7MC45
names: Similarity
messages: Belongs to the syntaxin family.

8364:tmem131
gene id: 8364:tmem131
uniprot id: A0A8J1J177
uniprot id: A0A8J1J3L5
uniprot id: A0A8J1J4M2
uniprot id: B4F6W0
names: Similarity
messages: Belongs to the TMEM131 family.

8364:cchcr1
gene id: 8364:cchcr1
uniprot id: A0A8J0SUT9
uniprot id: B0JZ34
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

8364:hhatl
gene id: 8364:hhatl
uniprot id: Q66IG1
names: Subcellular Location Annotation
messages: Membrane

8364:creb1
gene id: 8364:creb1
uniprot id: A0A8J0SXT0
uniprot id: Q6NVP9
names: Subcellular Location Annotation
messages: Nucleus

8364:caprin1
gene id: 8364:caprin1
uniprot id: A0A6I8R3U0
uniprot id: A0A8J0SKC6
uniprot id: A0A8J0SLL1
uniprot id: A0A8J0SLP4
uniprot id: Q5BL78
names: Similarity
messages: Belongs to the caprin family.

8364:hnmt
gene id: 8364:hnmt
uniprot id: F7CZC2
uniprot id: Q0V9P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
messages: Cytoplasm
messages: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
messages: Monomer.

8364:fam13a
gene id: 8364:fam13a
uniprot id: A0A6I8R912
uniprot id: A0A8J1JME8
uniprot id: A0A8J1JMF5
uniprot id: A0A8J1JMF9
uniprot id: A0A8J1JMG3
uniprot id: A0A8J1JMG8
uniprot id: A0A8J1JMH4
uniprot id: A0A8J1JPV9
uniprot id: A0A8J1JPW9
uniprot id: A0A8J1JPX4
names: Similarity
messages: Belongs to the FAM13 family.

8364:rfc2
gene id: 8364:rfc2
uniprot id: B4F6H8
names: Similarity
messages: Belongs to the activator 1 small subunits family.

8364:fbp2
gene id: 8364:fbp2
uniprot id: Q501L0
names: Similarity
messages: Belongs to the FBPase class 1 family.

8364:cpamd8
gene id: 8364:cpamd8
uniprot id: A0A6I8PW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:grpel2
gene id: 8364:grpel2
uniprot id: B5DED9
names: Similarity
messages: Belongs to the GrpE family.

8364:terf2ip
gene id: 8364:terf2ip
uniprot id: A0A6I8RTP3
uniprot id: A0A803K8J2
uniprot id: B8QB46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity).
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Homodimer. Component of the shelterin complex (telosome). Interacts with terf2; the interaction is direct (By similarity).
messages: Nucleus
messages: telomere

8364:LOC116406445
gene id: 8364:LOC116406445
uniprot id: A0A8J0QK83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8364:cit
gene id: 8364:cit
uniprot id: A0A8J1J1G0
uniprot id: A0A8J1J1G6
uniprot id: A0A8J1J1H8
uniprot id: B1WB68
uniprot id: F6T8M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Plays a role in cytokinesis. Displays serine/threonine protein kinase activity.

8364:cluap1
gene id: 8364:cluap1
uniprot id: A0A803KJS5
uniprot id: F6UDM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

8364:c5orf63
gene id: 8364:c5orf63
uniprot id: A0A6I8R942
uniprot id: A0A8J0SKQ4
names: Similarity
messages: Belongs to the glutaredoxin family.

8364:egfl7
gene id: 8364:egfl7
uniprot id: Q0IHL2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:atp11b
gene id: 8364:atp11b
uniprot id: A0A6I8QJS2
uniprot id: A0A8J0R3F9
uniprot id: A0A8J0R420
uniprot id: A0A8J1JJE5
uniprot id: A0A8J1JJE6
uniprot id: A0A8J1JJE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:gh1
gene id: 8364:gh1
uniprot id: F6WN03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

8364:LOC116411743
gene id: 8364:LOC116411743
uniprot id: A0A8J1JRC2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:tmem263
gene id: 8364:tmem263
uniprot id: Q6P1V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: May play a role in bone development.
messages: Membrane

8364:tdgf1.2
gene id: 8364:tdgf1.2
uniprot id: A0A6I8RMV1
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.

8364:LOC101730415
gene id: 8364:LOC101730415
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC100486901
gene id: 8364:LOC100486901
uniprot id: A0A6I8SPC5
names: Subcellular Location Annotation
messages: Membrane

8364:tomm7
gene id: 8364:tomm7
uniprot id: A9JSP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

8364:trim29
gene id: 8364:trim29
uniprot id: F6TTV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

8364:dntt
gene id: 8364:dntt
uniprot id: A0A803J8V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

8364:lyz
gene id: 8364:lyz
uniprot id: A0A6I8RID5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8364:creb3l4
gene id: 8364:creb3l4
uniprot id: F6QS27
uniprot id: Q08CW8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Controlled by regulated intramembrane proteolysis (RIP). A fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2) (By similarity).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus
messages: Transcriptional activator.

8364:actr1a
gene id: 8364:actr1a
uniprot id: F6ZZH4
names: Similarity
messages: Belongs to the actin family.

8364:rapsn
gene id: 8364:rapsn
uniprot id: Q6GL21
names: Similarity
messages: Belongs to the RAPsyn family.

8364:LOC108648074
gene id: 8364:LOC108648074
uniprot id: A0A8J1JYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:acadl
gene id: 8364:acadl
uniprot id: Q28BK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

8364:p3h1
gene id: 8364:p3h1
uniprot id: A1A5F1
names: Similarity
messages: Belongs to the leprecan family.

8364:arf11l.2
gene id: 8364:arf11l.2
uniprot id: A0A803JBN5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8364:tuba1cl.3
gene id: 8364:tuba1cl.3
uniprot id: Q6P8D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8364:arpc3
gene id: 8364:arpc3
uniprot id: A9UL86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

8364:LOC100496487
gene id: 8364:LOC100496487
uniprot id: F6XU18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:slc1a3
gene id: 8364:slc1a3
uniprot id: F7CSQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8364:clca1.2
gene id: 8364:clca1.2
uniprot id: A0A8J0QL21
names: Similarity
messages: Belongs to the CLCR family.

8364:grik1
gene id: 8364:grik1
uniprot id: A0A6I8S113
uniprot id: A0A6I8T0W3
uniprot id: A0A8J0R164
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:htr5a
gene id: 8364:htr5a
uniprot id: A0A6I8QWR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:scn2a
gene id: 8364:scn2a
uniprot id: A0A8J1IUH8
uniprot id: A0A8J1IXM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8364:LOC116409606
gene id: 8364:LOC116409606
uniprot id: A0A8J1JAZ1
names: Subcellular Location Annotation
messages: Membrane

8364:aldh1a1
gene id: 8364:aldh1a1
uniprot id: F7BRA8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:cd74
gene id: 8364:cd74
uniprot id: F6ZRD0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100488751
gene id: 8364:LOC100488751
uniprot id: A0A8J0QZ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

8364:sdhaf1
gene id: 8364:sdhaf1
uniprot id: A0A6I8RNA1
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

8364:cyp26b1
gene id: 8364:cyp26b1
uniprot id: Q08D50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Plays a key role in retinoic acid metabolism. Appears to be involved in the inactivation of all-trans-retinoic acid (RA).

8364:cnr1
gene id: 8364:cnr1
uniprot id: A0A803J9K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

8364:LOC100495415
gene id: 8364:LOC100495415
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:dnah6
gene id: 8364:dnah6
uniprot id: A0A6I8R5N1
uniprot id: A0A6I8RDK7
uniprot id: A0A8J1JN16
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:tmem170a
gene id: 8364:tmem170a
uniprot id: A9ULP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

8364:LOC105946315
gene id: 8364:LOC105946315
uniprot id: A0A8J0SD49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:pnpo
gene id: 8364:pnpo
uniprot id: B0BM73
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

8364:eef2.2
gene id: 8364:eef2.2
uniprot id: Q5FVX0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

8364:narf
gene id: 8364:narf
uniprot id: F6WBE8
names: Similarity
messages: Belongs to the NARF family.

8364:neurod4
gene id: 8364:neurod4
uniprot id: F6PS03
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116411013
gene id: 8364:LOC116411013
uniprot id: A0A8J1JL81
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tvp23b
gene id: 8364:tvp23b
uniprot id: A0A803KKH8
uniprot id: F6WZS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

8364:LOC100496215
gene id: 8364:LOC100496215
uniprot id: A0A6I8R799
uniprot id: A0A6I8SDV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8364:supv3l1
gene id: 8364:supv3l1
uniprot id: A0A6I8SXB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

8364:ska1
gene id: 8364:ska1
uniprot id: A0A8J0SDK6
uniprot id: B0BM28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKA1 family.
messages: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. In the complex, it mediates the interaction with microtubules.
messages: Component of the SKA1 complex, composed of ska1, ska2 and ska3.
messages: kinetochore
messages: spindle

8364:LOC100487954
gene id: 8364:LOC100487954
uniprot id: F6TCR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:tead1
gene id: 8364:tead1
uniprot id: A0A803J2U9
uniprot id: A0A803JP88
uniprot id: A0A803JUS0
uniprot id: A0A803K5Y2
uniprot id: A0A8J1JEG7
uniprot id: A0A8J1JEH0
uniprot id: A0A8J1JEH5
uniprot id: A0A8J1JEH6
uniprot id: A0A8J1JHZ0
names: Subcellular Location Annotation
messages: Nucleus

8364:tacc2
gene id: 8364:tacc2
uniprot id: A0A803KFE7
uniprot id: A0A8J1JT43
uniprot id: A0A8J1JT46
uniprot id: A0A8J1JT48
uniprot id: A0A8J1JT51
uniprot id: A0A8J1JT52
uniprot id: A0A8J1JT59
uniprot id: A0A8J1JVL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

8364:arglu1
gene id: 8364:arglu1
uniprot id: Q6P2W5
names: Similarity
messages: Belongs to the UPF0430 family.

8364:itgal
gene id: 8364:itgal
uniprot id: A0A8J1IXA5
uniprot id: A0A8J1IY21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:abcc3
gene id: 8364:abcc3
uniprot id: A0A8J1IYJ1
uniprot id: A9JRK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

8364:pex14
gene id: 8364:pex14
uniprot id: F6TTV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

8364:baf-l
gene id: 8364:baf-l
uniprot id: A0A6I8PJQ0
uniprot id: A0A8J0SKL3
uniprot id: A0A8J0SN95
uniprot id: A9UL77
uniprot id: F6ZIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myozenin family.
messages: Nucleus

8364:plcd4
gene id: 8364:plcd4
uniprot id: A0A6I8SP63
uniprot id: F6RLC5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus

8364:LOC116408620
gene id: 8364:LOC116408620
uniprot id: A0A8J1J539
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cfap20
gene id: 8364:cfap20
uniprot id: Q6GL74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP20 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (By similarity). Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity).
messages: Nucleus
messages: centriole
messages: cilium axoneme
messages: cilium basal body

8364:rps14
gene id: 8364:rps14
uniprot id: A0A803KGH9
uniprot id: F6YDV0
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

8364:marcksl1
gene id: 8364:marcksl1
uniprot id: Q28I11
names: Similarity
messages: Belongs to the MARCKS family.

8364:abo.4
gene id: 8364:abo.4
uniprot id: A0A6I8Q9Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

8364:zup1
gene id: 8364:zup1
uniprot id: Q28IN1
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

8364:ptprz1
gene id: 8364:ptprz1
uniprot id: A0A6I8REK8
uniprot id: A0A8J0QI61
uniprot id: A0A8J1J6C5
uniprot id: A0A8J1J6D0
uniprot id: A0A8J1J6D1
uniprot id: A0A8J1J8S2
uniprot id: A0A8J1J9T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

8364:fgf10
gene id: 8364:fgf10
uniprot id: B7ZSQ9
uniprot id: Q07G49
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:bloc1s6
gene id: 8364:bloc1s6
uniprot id: F6QBS2
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

8364:tlx2
gene id: 8364:tlx2
uniprot id: A0A803JTI5
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100491569
gene id: 8364:LOC100491569
uniprot id: F6RU66
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:LOC100488858
gene id: 8364:LOC100488858
uniprot id: A0A1B8Y4L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ccnj
gene id: 8364:ccnj
uniprot id: A0A803J883
names: Similarity
messages: Belongs to the cyclin family.

8364:prrt2
gene id: 8364:prrt2
uniprot id: A0A8J1IX75
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:LOC101732030
gene id: 8364:LOC101732030
uniprot id: A0A8J0T4H9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:lrrc8e
gene id: 8364:lrrc8e
uniprot id: Q68F79
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Heterohexamer. Oligomerizes with other LRRC8 proteins (lrrc8a, lrrc8c, lrrc8d and/or lrrc8b) to form a heterohexamer. Detected in a channel complex that contains lrrc8a, lrrc8c and lrrc8e. In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist.
messages: Lysosome membrane
messages: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires lrrc8a plus at least one other family member (lrrc8b, lrrc8c, lrrc8d or lrrc8e); channel characteristics depend on the precise subunit composition. Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis.
messages: The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.

8364:LOC108645362
gene id: 8364:LOC108645362
uniprot id: A0A8J1JI63
names: Subcellular Location Annotation
messages: Nucleus

8364:cyp2b6
gene id: 8364:cyp2b6
uniprot id: A4II90
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:dusp3
gene id: 8364:dusp3
uniprot id: A0A8J0QTX7
uniprot id: A0A8J0SUC1
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8364:sugp1
gene id: 8364:sugp1
uniprot id: Q28E21
names: Subcellular Location Annotation
messages: Nucleus

8364:mki67
gene id: 8364:mki67
uniprot id: A0A8J1JV30
uniprot id: A0A8J1JV36
uniprot id: A0A8J1JV37
uniprot id: A0A8J1JV39
uniprot id: A0A8J1JV42
uniprot id: A0A8J1JV43
uniprot id: A0A8J1JV44
uniprot id: A0A8J1JV47
uniprot id: A0A8J1JV48
uniprot id: A0A8J1JXJ5
uniprot id: A0A8J1JZ08
names: Subcellular Location Annotation
messages: Nucleus

8364:foxp2
gene id: 8364:foxp2
uniprot id: A0A6I8SNY6
uniprot id: A0A8J0S8T9
uniprot id: A0A8J0SEG3
uniprot id: A0A8J0SG76
uniprot id: A0A8J0SHD1
uniprot id: A4IIF5
uniprot id: F7DTZ3
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116408044
gene id: 8364:LOC116408044
uniprot id: A0A803JAR5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:satpa
gene id: 8364:satpa
uniprot id: A0A6I8SL51
names: Similarity
messages: Belongs to the SUA5 family.

8364:rpain
gene id: 8364:rpain
uniprot id: B1H156
names: Subcellular Location Annotation
messages: Nucleus

8364:atp5f1e
gene id: 8364:atp5f1e
uniprot id: A0A8J1J1K6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

8364:lin28b
gene id: 8364:lin28b
uniprot id: B4F6I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

8364:ccdc124
gene id: 8364:ccdc124
uniprot id: Q28HN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Midbody
messages: Required for proper progression of late cytokinetic stages.
messages: centrosome

8364:otop3
gene id: 8364:otop3
uniprot id: A0A803JVZ8
uniprot id: A9JTM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:etfb
gene id: 8364:etfb
uniprot id: Q6P7K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

8364:tmem18
gene id: 8364:tmem18
uniprot id: B7ZT19
uniprot id: Q28GF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane
messages: Nucleus membrane

8364:gpr180
gene id: 8364:gpr180
uniprot id: B4F6M2
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116406719
gene id: 8364:LOC116406719
uniprot id: A0A803K781
names: Subcellular Location Annotation
messages: Membrane

8364:lars2
gene id: 8364:lars2
uniprot id: A0A6I8QRP0
uniprot id: F7A3Z3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:renbp
gene id: 8364:renbp
uniprot id: A0A8J0T593
uniprot id: A9JTM3
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

8364:il1rapl2
gene id: 8364:il1rapl2
uniprot id: A0A803JU35
uniprot id: Q0IIY6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8364:phax
gene id: 8364:phax
uniprot id: A0A6R4ZQT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

8364:dcc
gene id: 8364:dcc
uniprot id: A0A6I8SSZ2
uniprot id: A0A8J0QLJ0
uniprot id: A0A8J0QZD1
uniprot id: A0A8J0QZR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

8364:hapln3
gene id: 8364:hapln3
uniprot id: Q28ET6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:loxl4
gene id: 8364:loxl4
uniprot id: A0A7D9NKV7
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

8364:LOC619584
gene id: 8364:LOC619584
uniprot id: A0A8J0R215
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:cln5
gene id: 8364:cln5
uniprot id: A0A8J0S8F6
uniprot id: F7CEB9
names: Similarity
messages: Belongs to the CLN5 family.

8364:il6st
gene id: 8364:il6st
uniprot id: A0A6I8QKR5
uniprot id: A0A6I8RZN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

8364:slc66a1
gene id: 8364:slc66a1
uniprot id: A0A803K9R0
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116408383
gene id: 8364:LOC116408383
uniprot id: A0A8J1IZK1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100488078
gene id: 8364:LOC100488078
uniprot id: F6PIC2
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:sbk2
gene id: 8364:sbk2
uniprot id: A0A8J0QPK2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:crisp1.11
gene id: 8364:crisp1.11
uniprot id: A0A8J1JQM4
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sumf2
gene id: 8364:sumf2
uniprot id: A0A6I8R3L8
uniprot id: A0A8J0PH60
uniprot id: Q5FVY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

8364:LOC116408758
gene id: 8364:LOC116408758
uniprot id: A0A8J1J716
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:chd6
gene id: 8364:chd6
uniprot id: A0A6I8RUE2
uniprot id: A0A8J1J150
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

8364:LOC116406804
gene id: 8364:LOC116406804
uniprot id: A0A8J1ISW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:vps37d
gene id: 8364:vps37d
uniprot id: A0A6I8RZ88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

8364:rab3ip
gene id: 8364:rab3ip
uniprot id: A0A803KJT4
uniprot id: F6W9L8
uniprot id: Q28G01
names: Similarity
messages: Belongs to the SEC2 family.

8364:emp1
gene id: 8364:emp1
uniprot id: A0A803KGT9
uniprot id: F7BNK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

8364:rxfp2
gene id: 8364:rxfp2
uniprot id: A0A8J0SHA0
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:agpat3
gene id: 8364:agpat3
uniprot id: Q66IJ5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8364:LOC116409653
gene id: 8364:LOC116409653
uniprot id: A0A8J1JC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sybu
gene id: 8364:sybu
uniprot id: A0A6I8PPW9
uniprot id: A0A8J0SQV9
uniprot id: Q28GV3
names: Subcellular Location Annotation
messages: Membrane

8364:foxd2
gene id: 8364:foxd2
uniprot id: A0A803KDN8
names: Subcellular Location Annotation
messages: Nucleus

8364:rpl7
gene id: 8364:rpl7
uniprot id: A0A803KHR9
uniprot id: F7CBI9
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

8364:tmem184b
gene id: 8364:tmem184b
uniprot id: A9UMR2
uniprot id: F7AE05
uniprot id: Q28C14
names: Subcellular Location Annotation
messages: Membrane

8364:MGC89174
gene id: 8364:MGC89174
uniprot id: A0A803KIN5
uniprot id: F6TKZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8364:acox2
gene id: 8364:acox2
uniprot id: A0A6I8Q8D8
uniprot id: Q28EC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

8364:slc18b1
gene id: 8364:slc18b1
uniprot id: B7ZU34
uniprot id: Q07G00
names: Subcellular Location Annotation
messages: Membrane

8364:pex2
gene id: 8364:pex2
uniprot id: Q28DK5
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

8364:znrd1
gene id: 8364:znrd1
uniprot id: A0A6I8RIK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

8364:LOC116409852
gene id: 8364:LOC116409852
uniprot id: A0A803JD09
uniprot id: A0A8J1JC76
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8364:myoz2
gene id: 8364:myoz2
uniprot id: A0A803JLQ6
uniprot id: A0A803KL58
uniprot id: A0A8J0SC42
uniprot id: A0A8J0SKH7
uniprot id: F6ZIW6
names: Similarity
messages: Belongs to the myozenin family.

8364:stat1
gene id: 8364:stat1
uniprot id: A0A8J0T3P7
uniprot id: F6Q0M0
uniprot id: Q08D02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8364:rps6ka2
gene id: 8364:rps6ka2
uniprot id: A0A803JCT7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8364:LOC100494017
gene id: 8364:LOC100494017
uniprot id: A0A8J1J8I2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:fam219a
gene id: 8364:fam219a
uniprot id: A0A8J1IZ77
uniprot id: A0A8J1IZ90
names: Similarity
messages: Belongs to the FAM219 family.

8364:smad6.2
gene id: 8364:smad6.2
uniprot id: A0A1B8XWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8364:pold2
gene id: 8364:pold2
uniprot id: Q6DJ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

8364:dynll2
gene id: 8364:dynll2
uniprot id: A0A803KJ35
uniprot id: F6SLV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

8364:ep300
gene id: 8364:ep300
uniprot id: A0A8J0QK55
uniprot id: A0A8J0R367
uniprot id: A0A8J0R3J0
uniprot id: F7DX95
names: Subcellular Location Annotation
messages: Cytoplasm

8364:cryga.1
gene id: 8364:cryga.1
uniprot id: A0A803K1L9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:aacs
gene id: 8364:aacs
uniprot id: Q28BL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates acetoacetate to acetoacetyl-CoA.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: cytosol

8364:cflar
gene id: 8364:cflar
uniprot id: A0A6I8PWX3
uniprot id: A0A6I8PY92
uniprot id: A0A8J0QMA1
uniprot id: A0A8J0SYN4
names: Similarity
messages: Belongs to the peptidase C14A family.

8364:tenm3
gene id: 8364:tenm3
uniprot id: A0A8J1J0C3
uniprot id: A0A8J1J0C4
uniprot id: A0A8J1J0C8
uniprot id: A0A8J1J0D5
uniprot id: A0A8J1J0E2
uniprot id: A0A8J1J2N9
uniprot id: A0A8J1J3M1
uniprot id: A0A8J1J3M6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC116409763
gene id: 8364:LOC116409763
uniprot id: A0A6I8PV84
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:glrx
gene id: 8364:glrx
uniprot id: Q28I60
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

8364:tmprss2.4
gene id: 8364:tmprss2.4
uniprot id: A0A8J1J3G1
uniprot id: A0A8J1J6V7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:pth2r
gene id: 8364:pth2r
uniprot id: A0A803KFJ5
names: Subcellular Location Annotation
messages: Membrane

8364:kcnn1
gene id: 8364:kcnn1
uniprot id: A0A803KI65
uniprot id: F6SM41
names: Subcellular Location Annotation
messages: Membrane

8364:MGC69466
gene id: 8364:MGC69466
uniprot id: Q6GLA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:ppie
gene id: 8364:ppie
uniprot id: A0A6I8QDH7
uniprot id: A0A8J0R0S9
uniprot id: F7EEK8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:fam219b
gene id: 8364:fam219b
uniprot id: A0A8J0SSF6
uniprot id: A0A8J0SZF8
names: Similarity
messages: Belongs to the FAM219 family.

8364:slc27a2
gene id: 8364:slc27a2
uniprot id: A0A8J0QWD8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8364:slc26a6
gene id: 8364:slc26a6
uniprot id: A0A6I8QHX3
uniprot id: Q0VA12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8364:LOC100496331
gene id: 8364:LOC100496331
uniprot id: A0A6I8RVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:LOC116408926
gene id: 8364:LOC116408926
uniprot id: A0A803K036
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:b4galt6
gene id: 8364:b4galt6
uniprot id: A0A8J0T3W9
uniprot id: Q28CK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8364:LOC101732756
gene id: 8364:LOC101732756
uniprot id: A0A803KAT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Membrane

8364:sema3c
gene id: 8364:sema3c
uniprot id: A0A6I8QK53
uniprot id: A0A8J0QXX0
uniprot id: F7AQT4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:LOC101734540
gene id: 8364:LOC101734540
uniprot id: A0A8J0R7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dlx3
gene id: 8364:dlx3
uniprot id: Q5BL47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

8364:cdk4
gene id: 8364:cdk4
uniprot id: Q28J99
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:faf2
gene id: 8364:faf2
uniprot id: Q28BP9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Lipid droplet
messages: Plays an important role in endoplasmic reticulum associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation.

8364:LOC101732669
gene id: 8364:LOC101732669
uniprot id: A0A8J1IXA7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:lpcat2
gene id: 8364:lpcat2
uniprot id: A0A6I8SKU1
uniprot id: A0A8J0SAV0
uniprot id: A0A8J0T1W1
uniprot id: A4II37
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8364:LOC101732940
gene id: 8364:LOC101732940
uniprot id: A0A803K8B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

8364:LOC101735260
gene id: 8364:LOC101735260
uniprot id: A0A8J0R6C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:inmt
gene id: 8364:inmt
uniprot id: B5DFP9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:fam32a
gene id: 8364:fam32a
uniprot id: B0JZ89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM32 family.
messages: May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
messages: Nucleus

8364:msn
gene id: 8364:msn
uniprot id: A0A6I8QMU2
uniprot id: A0A8J0QMQ0
uniprot id: A0A8J0STP9
uniprot id: A0A8J1IPZ8
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8364:t2r46
gene id: 8364:t2r46
uniprot id: Q2AB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:tnk2
gene id: 8364:tnk2
uniprot id: A0A6I8QRK7
uniprot id: A0A8J0SDG6
uniprot id: A0A8J0SLU8
uniprot id: A0A8J0SN38
uniprot id: A0A8J1JHF9
uniprot id: A0A8J1JHG3
uniprot id: A0A8J1JJV9
uniprot id: A0A8J1JJW4
uniprot id: A0A8J1JKZ9
uniprot id: A4IGR9
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

8364:ska3
gene id: 8364:ska3
uniprot id: A0A7D9NK64
uniprot id: B0BM16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKA3 family.
messages: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
messages: Component of the SKA1 complex, composed of ska1, ska2 and ska3.
messages: kinetochore
messages: spindle

8364:acp7
gene id: 8364:acp7
uniprot id: A0A6I8Q453
uniprot id: A0A803J5Q9
uniprot id: A0A8J0QG96
uniprot id: A0A8J1IL21
uniprot id: A0A8J1IN08
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

8364:tcea3
gene id: 8364:tcea3
uniprot id: Q28G46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

8364:syne1
gene id: 8364:syne1
uniprot id: A0A803JN15
uniprot id: A0A8J0STQ0
uniprot id: A0A8J0T0Q5
uniprot id: A0A8J0T350
uniprot id: A0A8J0T3Y4
uniprot id: F7BMN0
names: Similarity
messages: Belongs to the nesprin family.

8364:garem1
gene id: 8364:garem1
uniprot id: A0A8J0QPD6
uniprot id: A0A8J1JNQ0
uniprot id: A0A8J1JNQ3
uniprot id: F7ETG3
names: Similarity
messages: Belongs to the GAREM family.

8364:trpv4l.2
gene id: 8364:trpv4l.2
uniprot id: A0A8J0SQF6
names: Subcellular Location Annotation
messages: Membrane

8364:trpm1
gene id: 8364:trpm1
uniprot id: A0A8J1JAW9
uniprot id: A0A8J1JAX1
uniprot id: A0A8J1JAX2
uniprot id: A0A8J1JEE5
names: Subcellular Location Annotation
messages: Membrane

8364:sncg
gene id: 8364:sncg
uniprot id: Q28F65
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

8364:lyve1
gene id: 8364:lyve1
uniprot id: A0A6I8RLQ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:npy2rl
gene id: 8364:npy2rl
uniprot id: A0A6I8PTM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:atp5f1d
gene id: 8364:atp5f1d
uniprot id: F6TBL3
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

8364:lcor
gene id: 8364:lcor
uniprot id: A0A8J1JRU5
names: Subcellular Location Annotation
messages: Nucleus

8364:gatad1
gene id: 8364:gatad1
uniprot id: B1H2T9
names: Subcellular Location Annotation
messages: Nucleus

8364:slc24a2
gene id: 8364:slc24a2
uniprot id: A0A6I8RJ06
uniprot id: A0A8J1IP46
uniprot id: F6Z301
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

8364:agxt
gene id: 8364:agxt
uniprot id: A0A6I8R995
uniprot id: Q6DIW8
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

8364:nat16
gene id: 8364:nat16
uniprot id: Q0P4Y1
names: Function
names: Miscellaneous
messages: Enzyme responsible for the N-acetyl-histidine (NAH) synthesis, which is a major constituent of brain and lens of ectothermic vertebrates.
messages: Strong histidine N-acetyltransferase activity has been detected in ectothermic vertebrates and not in endothermic birds and mammals.

8364:krt12.4
gene id: 8364:krt12.4
uniprot id: B0BMI0
names: Similarity
messages: Belongs to the intermediate filament family.

8364:kcnab2
gene id: 8364:kcnab2
uniprot id: A0A6I8QR52
uniprot id: A0A6I8SGT3
uniprot id: A0A6I8SK97
uniprot id: A0A8J0ST87
uniprot id: A0A8J0SU57
uniprot id: A0A8J0T298
uniprot id: A0A8J1JWB2
uniprot id: A0A8J1JWC1
uniprot id: F7B353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AF4 family.
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: axon
messages: cytoskeleton
messages: synaptosome

8364:ccdc13
gene id: 8364:ccdc13
uniprot id: F7AFE7
names: Subcellular Location Annotation
messages: Nucleus

8364:cpn1
gene id: 8364:cpn1
uniprot id: Q5FVZ6
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:cryl1
gene id: 8364:cryl1
uniprot id: B1H3F7
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

8364:slc47a1
gene id: 8364:slc47a1
uniprot id: A0A6I8SPR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

8364:mbd4
gene id: 8364:mbd4
uniprot id: Q28HB5
names: Subcellular Location Annotation
messages: Nucleus

8364:eef2k
gene id: 8364:eef2k
uniprot id: A0A6I8QMH9
uniprot id: A0A6I8QRU7
uniprot id: A0A8J0SMV1
uniprot id: B0JZD6
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

8364:pou5f3.1
gene id: 8364:pou5f3.1
uniprot id: F6TLT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8364:atp23
gene id: 8364:atp23
uniprot id: A0A8J0T2B5
uniprot id: Q5BKJ4
names: Similarity
messages: Belongs to the peptidase M76 family.

8364:dio3
gene id: 8364:dio3
uniprot id: A0A8J0QA53
uniprot id: A9ULG7
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

8364:kcnk4
gene id: 8364:kcnk4
uniprot id: A0A803JN99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8364:jmjd1c
gene id: 8364:jmjd1c
uniprot id: A0A6I8QUV0
uniprot id: A0A7D9NLN0
uniprot id: A0A8J1JTJ7
uniprot id: A0A8J1JW00
uniprot id: A0A8J1JXC1
names: Subcellular Location Annotation
messages: Nucleus

8364:atp2c1
gene id: 8364:atp2c1
uniprot id: A0A6I8QSW5
uniprot id: A0A6I8RLL7
uniprot id: F7ETW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

8364:slc16a12
gene id: 8364:slc16a12
uniprot id: F6ZTR2
uniprot id: Q6P2X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.
messages: Membrane

8364:folr1
gene id: 8364:folr1
uniprot id: A0A8J0SQV7
uniprot id: A0A8J0T0C1
uniprot id: A0A8J0T128
uniprot id: F7CGN2
uniprot id: Q6P638
names: Similarity
messages: Belongs to the folate receptor family.

8364:hba4
gene id: 8364:hba4
uniprot id: Q38IV9
names: Similarity
messages: Belongs to the globin family.

8364:dohh
gene id: 8364:dohh
uniprot id: B0JYS8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

8364:myo7b
gene id: 8364:myo7b
uniprot id: A0A6I8QMW0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:gbp7
gene id: 8364:gbp7
uniprot id: A0A803JLU8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:dcaf12
gene id: 8364:dcaf12
uniprot id: Q6P809
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DCAF12 family.
messages: Component of the DCX(DCAF12) E3 ubiquitin ligase complex, at least composed of cul4 (cul4a or cul4b), ddb1, dcaf12 and rbx1.
messages: Cytoplasm
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, leading to their ubiquitination and degradation.
messages: centrosome

8364:trim59
gene id: 8364:trim59
uniprot id: F6WLC6
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

8364:ngdn
gene id: 8364:ngdn
uniprot id: Q28IV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: Cytoplasm
messages: May inhibit mRNA translation.
messages: Nucleus

8364:scamp5.1
gene id: 8364:scamp5.1
uniprot id: A0A8J0STA0
uniprot id: Q28F21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Belongs to the SCAMP family. SCAMP5 subfamily.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Recycling endosome membrane
messages: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines. Probably acts in cooperation with the SNARE machinery (By similarity).
messages: synaptic vesicle membrane
messages: trans-Golgi network membrane

8364:LOC100491404
gene id: 8364:LOC100491404
uniprot id: A0A8J0STW2
names: Similarity
messages: Belongs to the HEBP family.

8364:LOC100488368
gene id: 8364:LOC100488368
uniprot id: F7C991
names: Subcellular Location Annotation
messages: Secreted

8364:ccna1
gene id: 8364:ccna1
uniprot id: Q28CQ2
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

8364:npsr1
gene id: 8364:npsr1
uniprot id: A0A6I8Q3X7
uniprot id: A0A8J1JR15
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:itga9
gene id: 8364:itga9
uniprot id: F6U9K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:LOC101731903
gene id: 8364:LOC101731903
uniprot id: A0A6I8S2J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8364:LOC100492223
gene id: 8364:LOC100492223
uniprot id: F6PNA6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:atg2b
gene id: 8364:atg2b
uniprot id: A0JPA9
uniprot id: F7BR87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

8364:hoxd4
gene id: 8364:hoxd4
uniprot id: F6VY66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:fign
gene id: 8364:fign
uniprot id: A0A6I8RKM8
uniprot id: A0A8J0QM07
uniprot id: A0A8J0R2T8
uniprot id: A0A8J1IWE5
names: Similarity
messages: Belongs to the AAA ATPase family.

8364:LOC100486100
gene id: 8364:LOC100486100
uniprot id: A0A8J0QY95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rps29
gene id: 8364:rps29
uniprot id: Q28D24
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

8364:LOC108646287
gene id: 8364:LOC108646287
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:tyro3
gene id: 8364:tyro3
uniprot id: A0A6I8QYX9
uniprot id: A0A8J0SWM1
uniprot id: A0A8J1IPM3
uniprot id: A0JM20
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
messages: Cell membrane
messages: May be involved in cell adhesion processes, particularly in the central nervous system.
messages: Membrane
messages: Tyrosine phosphorylated upon receptor stimulation.

8364:LOC100496745
gene id: 8364:LOC100496745
uniprot id: A0A8J1JI72
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:serpina3k
gene id: 8364:serpina3k
uniprot id: A0A8J0QLS9
names: Similarity
messages: Belongs to the serpin family.

8364:nek2
gene id: 8364:nek2
uniprot id: A0A6I8Q0M3
uniprot id: A0A8J1IL35
uniprot id: F7B0N9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:itga6
gene id: 8364:itga6
uniprot id: A0A6I8PZ36
uniprot id: A0A6I8RG79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:LOC116408759
gene id: 8364:LOC116408759
uniprot id: A0A8J1J3L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:csgalnact1
gene id: 8364:csgalnact1
uniprot id: F7E1T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

8364:cdh19
gene id: 8364:cdh19
uniprot id: A0A7D9NJV8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8364:phactr1
gene id: 8364:phactr1
uniprot id: B5DE18
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

8364:LOC100485081
gene id: 8364:LOC100485081
uniprot id: A0A6I8SFV2
uniprot id: F7EU05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:znf711
gene id: 8364:znf711
uniprot id: A0A8J0QFH4
uniprot id: A0A8J1K1Y2
uniprot id: F7B6U1
names: Subcellular Location Annotation
messages: Nucleus

8364:eif1b
gene id: 8364:eif1b
uniprot id: Q6P8F5
names: Similarity
messages: Belongs to the SUI1 family.

8364:tbxas1
gene id: 8364:tbxas1
uniprot id: A0A8J1J6W5
uniprot id: B0JZE2
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:snca
gene id: 8364:snca
uniprot id: A4IH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse

8364:cyp4v2.1
gene id: 8364:cyp4v2.1
uniprot id: A0A8J0QNN5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:zfx
gene id: 8364:zfx
uniprot id: F6ZHV3
names: Subcellular Location Annotation
messages: Nucleus

8364:dgkk
gene id: 8364:dgkk
uniprot id: A0A6I8QSL2
uniprot id: A0A6I8S2Q6
uniprot id: A0A8J0R5N0
uniprot id: A0A8J0R6N0
uniprot id: A0A8J1INJ7
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8364:LOC101731070
gene id: 8364:LOC101731070
uniprot id: A0A6I8SR26
uniprot id: A0A8J1JR02
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:LOC116409818
gene id: 8364:LOC116409818
uniprot id: A0A8J1JBK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:zic2
gene id: 8364:zic2
uniprot id: F7B7T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

8364:cldn4
gene id: 8364:cldn4
uniprot id: Q28IP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:mocs3
gene id: 8364:mocs3
uniprot id: A0A6I8R184
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

8364:LOC105946653
gene id: 8364:LOC105946653
uniprot id: A0A8J0S8Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cacng1
gene id: 8364:cacng1
uniprot id: Q5XHK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

8364:pds5a
gene id: 8364:pds5a
uniprot id: F6ZCC3
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

8364:LOC116411028
gene id: 8364:LOC116411028
uniprot id: A0A8J1JNP4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:surf4.1
gene id: 8364:surf4.1
uniprot id: Q28IU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

8364:znf592
gene id: 8364:znf592
uniprot id: Q0P4Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

8364:LOC105945136
gene id: 8364:LOC105945136
uniprot id: A0A8J0SJ16
uniprot id: A0A8J1JBJ5
names: Similarity
messages: Belongs to the dermatopontin family.

8364:rpf2
gene id: 8364:rpf2
uniprot id: A0A8J0SNR5
uniprot id: F6SA27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

8364:ece1
gene id: 8364:ece1
uniprot id: A0A803J6U3
uniprot id: A0A803JU36
names: Function
messages: Converts big endothelin-1 to endothelin-1.

8364:col4a1
gene id: 8364:col4a1
uniprot id: A0A6I8Q7J4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

8364:tmem184a
gene id: 8364:tmem184a
uniprot id: Q28GY9
names: Subcellular Location Annotation
messages: Membrane

8364:lsm4
gene id: 8364:lsm4
uniprot id: A0A8J0SHP0
uniprot id: Q6P334
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

8364:cadm2
gene id: 8364:cadm2
uniprot id: A0A803J5A7
uniprot id: A0A8J1J4W9
uniprot id: Q6DJ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nectin family.
messages: Membrane

8364:ss18
gene id: 8364:ss18
uniprot id: A0A6I8PTQ5
uniprot id: A0A6I8R740
uniprot id: A0A8J0SRI3
uniprot id: Q0VGY6
names: Similarity
messages: Belongs to the SS18 family.

8364:pelo
gene id: 8364:pelo
uniprot id: Q28EH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.
messages: Nucleus

8364:LOC101734966
gene id: 8364:LOC101734966
uniprot id: A0A6I8QFW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

8364:tmem43
gene id: 8364:tmem43
uniprot id: A0A6I8RBW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

8364:LOC100486484
gene id: 8364:LOC100486484
uniprot id: A0A6I8S6K6
uniprot id: A0A8J0QNT6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8364:slc12a4
gene id: 8364:slc12a4
uniprot id: A0A6I8RJT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

8364:hcn2
gene id: 8364:hcn2
uniprot id: A0A8J0QW74
uniprot id: A0A8J1JZ60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8364:grhpr.2
gene id: 8364:grhpr.2
uniprot id: Q66KM4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

8364:LOC100488558
gene id: 8364:LOC100488558
uniprot id: A0A6I8SFI7
names: Similarity
messages: Belongs to the FAM98 family.

8364:prdm2
gene id: 8364:prdm2
uniprot id: A0A8J1JS50
uniprot id: B3DM80
names: Subcellular Location Annotation
messages: Nucleus

8364:pspn
gene id: 8364:pspn
uniprot id: A0A8J0SBR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

8364:rnf146
gene id: 8364:rnf146
uniprot id: Q66JE4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated proteins. Neuroprotective protein. Protects against cell death induced by DNA damaging agents and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
messages: Nucleus
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: cytosol

8364:LOC100497952
gene id: 8364:LOC100497952
uniprot id: A0A8J0QSW2
names: Similarity
messages: Belongs to the SUA5 family.

8364:LOC108646199
gene id: 8364:LOC108646199
uniprot id: A0A8J1J8D8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101733742
gene id: 8364:LOC101733742
uniprot id: A0A8J1JLT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:nodal5
gene id: 8364:nodal5
uniprot id: A0A8J0QZP1
uniprot id: F6ZQV5
names: Similarity
messages: Belongs to the TGF-beta family.

8364:tgfbr2.2
gene id: 8364:tgfbr2.2
uniprot id: A0A6I8T273
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: Membrane raft

8364:svbp
gene id: 8364:svbp
uniprot id: A0A6I8RF78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

8364:MGC75760
gene id: 8364:MGC75760
uniprot id: F7CB89
uniprot id: Q6PBE1
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

8364:ptmap12
gene id: 8364:ptmap12
uniprot id: Q28G57
names: Similarity
messages: Belongs to the pro/parathymosin family.

8364:LOC100493036
gene id: 8364:LOC100493036
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116407762
gene id: 8364:LOC116407762
uniprot id: A0A803JSE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actinoporin family. Sea anemone subfamily.
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

8364:prmt1
gene id: 8364:prmt1
uniprot id: A0A5S6KAT5
uniprot id: A0A8J0SQF2
uniprot id: Q28F07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Methylates ilf3 to regulate its DNA-binding activity. Required for neural induction, playing a key role in the control of epidermal versus neural cell fate choice (By similarity). Methylates cirbp to regulate its subcellular location. Acts transiently during metamorphosis as a transcription coactivator, enhancing thyroid hormone (T3) receptor (TR)-mediated transcription by enhancing TR binding to the T3 response element (TRE), and histone modification through recruitment of other coactivators.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Cytoplasm
messages: Homodimer. Homooctamer; individual homodimers associates to form a homooctamer and homooligomerization is required for proper localization to the cell membrane. Individual homodimers can associate to form a homohexamer (By similarity). Component of a complex with lsm14a/rap55a. Interacts with cirbp (By similarity).
messages: Nucleus
messages: cytosol
messages: nucleoplasm

8364:abraxas1
gene id: 8364:abraxas1
uniprot id: Q28HX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Component of the BRCA1-A complex. Component of the BRISC complex. Interacts directly (when phosphorylated at Ser-405) with brca1. Homodimer. The phosphorylated homodimer can interact directly with two brca1 chains, giving rise to a heterotetramer (By similarity).
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (By similarity).
messages: Nucleus
messages: Phosphorylation of Ser-405 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1.

8364:optn
gene id: 8364:optn
uniprot id: A0A8J0R255
uniprot id: A0A8J0T1B3
uniprot id: A0A8J0T2L1
uniprot id: F6UGX6
uniprot id: F6Z6G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cytoplasmic vesicle
messages: Endosome
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: axon
messages: cytoskeleton
messages: perinuclear region
messages: trans-Golgi network

8364:bbof1
gene id: 8364:bbof1
uniprot id: F7D7B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
messages: Belongs to the BBOF1 family.
messages: cilium basal body

8364:mrps17
gene id: 8364:mrps17
uniprot id: Q28FV0
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

8364:des.1
gene id: 8364:des.1
uniprot id: Q6P869
names: Similarity
messages: Belongs to the intermediate filament family.

8364:ccdc47
gene id: 8364:ccdc47
uniprot id: B4F6K6
uniprot id: F6X650
names: Subcellular Location Annotation
messages: Membrane
messages: Rough endoplasmic reticulum membrane

8364:myo3a
gene id: 8364:myo3a
uniprot id: A0A803J261
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

8364:LOC116408630
gene id: 8364:LOC116408630
uniprot id: A0A8J1J652
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8364:LOC100490072
gene id: 8364:LOC100490072
uniprot id: A0A8J1J815
names: Similarity
messages: Belongs to the TGF-beta family.

8364:slc6a19
gene id: 8364:slc6a19
uniprot id: F6WWA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:tubb4b
gene id: 8364:tubb4b
uniprot id: A0A8J0SMF4
uniprot id: Q0IIR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8364:itga2b.1
gene id: 8364:itga2b.1
uniprot id: A0A6I8Q5U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:LOC116412173
gene id: 8364:LOC116412173
uniprot id: A0A8J1JUW2
names: Subcellular Location Annotation
messages: Membrane

8364:cbwd1.1
gene id: 8364:cbwd1.1
uniprot id: A0A8J1IZF4
uniprot id: B0JZ56
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:slc46a3
gene id: 8364:slc46a3
uniprot id: A0A6I8PQK3
names: Subcellular Location Annotation
messages: Membrane

8364:med8
gene id: 8364:med8
uniprot id: Q08BU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: Component of the Mediator complex. May be part of a multisubunit E3 ubiquitin-protein ligase complex (By similarity).
messages: Nucleus

8364:nr2f2
gene id: 8364:nr2f2
uniprot id: A0A803KGK3
uniprot id: F7C0J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:trappc1
gene id: 8364:trappc1
uniprot id: Q642T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

8364:tbl3
gene id: 8364:tbl3
uniprot id: A4IH94
uniprot id: Q28DK2
names: Subcellular Location Annotation
messages: nucleolus

8364:ghrh
gene id: 8364:ghrh
uniprot id: A0A6I8QK26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

8364:LOC116412382
gene id: 8364:LOC116412382
uniprot id: A0A8J1JWZ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:phc1
gene id: 8364:phc1
uniprot id: A0A8J1JXH5
uniprot id: F6TCW7
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116407752
gene id: 8364:LOC116407752
uniprot id: A0A8J1IYL3
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:adsl
gene id: 8364:adsl
uniprot id: Q6GLC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

8364:dcp2
gene id: 8364:dcp2
uniprot id: Q28DQ4
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

8364:LOC101733358
gene id: 8364:LOC101733358
uniprot id: A0A6I8QI97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116409589
gene id: 8364:LOC116409589
uniprot id: A0A8J1J8J1
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100487440
gene id: 8364:LOC100487440
uniprot id: F7E9P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:pqlc2l
gene id: 8364:pqlc2l
uniprot id: B3DL12
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101732995
gene id: 8364:LOC101732995
uniprot id: F6R1F0
uniprot id: Q800C0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity. Regulates the expression of specific mesodermal and neural genes. Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region. Acts with wnt11 to induce Spemann organizer cells and induce axis formation (By similarity). The unprocessed protein antagonizes bmp-signaling.
messages: Expressed in the dorsal marginal region of late blastula, becoming restricted to the Spemann organizer at the early gastrula stage.
messages: First detected at the blastula stage (stage 8). Expression peaks through the mid-blastula (stage 8.5) to early gastrula (stage 10) and then decreases during gastrulation.
messages: Monomer. The propeptide region interacts with bmp4 in a non-covalent manner.
messages: Secreted
messages: The propeptide region and the N- and C-terminal thirds of the mature protein are necessary for neural induction activity. Although cleavage doesn't appear essential for activity, residues surrounding the cleavage site are necessary for activity (By similarity). The propeptide region is both necessary and sufficient for bmp-inhibitory activity.

8364:ncbp2
gene id: 8364:ncbp2
uniprot id: Q6DES0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By simi…
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Cytoplasm
messages: Nucleus

8364:plxna3
gene id: 8364:plxna3
uniprot id: Q6DEW8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:krt54
gene id: 8364:krt54
uniprot id: A0A8J0QWN4
names: Similarity
messages: Belongs to the intermediate filament family.

8364:fam102a
gene id: 8364:fam102a
uniprot id: A0JM34
names: Similarity
messages: Belongs to the FAM102 family.

8364:adh4
gene id: 8364:adh4
uniprot id: A0A8J0QQ44
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.

8364:lmbr1
gene id: 8364:lmbr1
uniprot id: Q5U4X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Membrane
messages: Putative membrane receptor.

8364:eif4g3
gene id: 8364:eif4g3
uniprot id: A0A6I8S4W2
uniprot id: A0A8J1JS59
uniprot id: A0A8J1JS75
uniprot id: A0A8J1JUM6
uniprot id: A0A8J1JVY5
uniprot id: A0A8J1JVZ3
uniprot id: B4F6U8
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

8364:stt3b
gene id: 8364:stt3b
uniprot id: A0A6I8Q2Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

8364:acmsd
gene id: 8364:acmsd
uniprot id: F7EHT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

8364:pes1
gene id: 8364:pes1
uniprot id: A0A8J0SYV7
uniprot id: A0A8J1J9I4
uniprot id: Q6DEV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, composed of bop1, pes1 and wdr12. The complex is held together by bop1, which interacts with pes1 via its N-terminal domain and with wdr12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

8364:plscr1
gene id: 8364:plscr1
uniprot id: A0A8J1JLD6
uniprot id: B5DDV8
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8364:LOC100497863
gene id: 8364:LOC100497863
uniprot id: A0A8J1IR08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8364:LOC116407761
gene id: 8364:LOC116407761
uniprot id: A0A8J1IXW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actinoporin family. Sea anemone subfamily.
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

8364:pdx1
gene id: 8364:pdx1
uniprot id: F7DWT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:krt8.2
gene id: 8364:krt8.2
uniprot id: A0A8J0PII1
uniprot id: A0A8J1IVM7
uniprot id: Q28D97
names: Similarity
messages: Belongs to the intermediate filament family.

8364:crk
gene id: 8364:crk
uniprot id: Q6GLF5
names: Similarity
messages: Belongs to the CRK family.

8364:dkk3
gene id: 8364:dkk3
uniprot id: A0A803JY38
uniprot id: B1WBF8
names: Similarity
messages: Belongs to the dickkopf family.

8364:tmc3
gene id: 8364:tmc3
uniprot id: A0A8J0SHZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8364:rbl1
gene id: 8364:rbl1
uniprot id: A0A6I8RJ97
uniprot id: B4F726
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

8364:prkca
gene id: 8364:prkca
uniprot id: A0A8J1IWQ9
uniprot id: A0A8J1IZY1
uniprot id: A0JM65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

8364:wsb1
gene id: 8364:wsb1
uniprot id: Q6P1V3
names: Domain
names: Function
names: Subunit
messages: Component of a probable ECS E3 ubiquitin-protein ligase complex that contains the Elongin BC complex.
messages: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
messages: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

8364:pdcd10
gene id: 8364:pdcd10
uniprot id: A0A6I8RFV9
uniprot id: Q6DF07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.

8364:LOC100494248
gene id: 8364:LOC100494248
uniprot id: A0A803JLK9
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100490096
gene id: 8364:LOC100490096
uniprot id: A0A6I8RFE8
uniprot id: A0A8J1JCB7
uniprot id: F6RTT3
names: Subcellular Location Annotation
messages: Cytoplasm

8364:cckbr
gene id: 8364:cckbr
uniprot id: A0A803JLM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:st3gal2.2
gene id: 8364:st3gal2.2
uniprot id: F6RJ90
uniprot id: Q70D56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:pik3c2b
gene id: 8364:pik3c2b
uniprot id: A0A8J1J4A5
uniprot id: A0A8J1J4B3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8364:lipg
gene id: 8364:lipg
uniprot id: A0A8J0SU39
uniprot id: F6XB15
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:sctr
gene id: 8364:sctr
uniprot id: A0A8J1IZ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8364:camsap3
gene id: 8364:camsap3
uniprot id: A0A803JFP0
uniprot id: A0A803JW66
uniprot id: A0A8J1JDU3
uniprot id: F6X904
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

8364:LOC100491968
gene id: 8364:LOC100491968
uniprot id: A0A6I8PQY9
names: Subcellular Location Annotation
messages: Secreted

8364:LOC105946865
gene id: 8364:LOC105946865
uniprot id: A0A8J0SAL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ctr9
gene id: 8364:ctr9
uniprot id: Q6DEU9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II (By similarity). PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).
messages: Component of the PAF1 complex, which at least consists of cdc73, paf1, leo1, ctr9 and rtf1 (By similarity). The PAF1 complex interacts with PHF5A (By similarity).
messages: Nucleus speckle

8364:mgst2
gene id: 8364:mgst2
uniprot id: A0A6I8RJ83
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8364:armc1
gene id: 8364:armc1
uniprot id: Q66JK0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

8364:taf7
gene id: 8364:taf7
uniprot id: A0A803KHG0
uniprot id: F7BJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

8364:hacd3
gene id: 8364:hacd3
uniprot id: A0A6I8PWD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC101732307
gene id: 8364:LOC101732307
uniprot id: A0A8J1IZM3
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:LOC116406794
gene id: 8364:LOC116406794
uniprot id: A0A8J1IPP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cldn10
gene id: 8364:cldn10
uniprot id: A0A6I8RV10
uniprot id: A0A8J1J4W7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:srp9
gene id: 8364:srp9
uniprot id: A4IIH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

8364:pias1
gene id: 8364:pias1
uniprot id: A0A8J0QZF8
uniprot id: F6YUL3
names: Similarity
messages: Belongs to the PIAS family.

8364:kif14
gene id: 8364:kif14
uniprot id: A0A8J0SDA7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:LOC101731886
gene id: 8364:LOC101731886
uniprot id: A0A803KES9
uniprot id: A0A8J0SPH3
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:dydc1
gene id: 8364:dydc1
uniprot id: F6URR2
names: Similarity
messages: Belongs to the dpy-30 family.

8364:adamts5
gene id: 8364:adamts5
uniprot id: A0A6I8R102
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:etfdh
gene id: 8364:etfdh
uniprot id: Q6GL88
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

8364:rgma
gene id: 8364:rgma
uniprot id: A0A8J1JAG2
uniprot id: Q6P8A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8364:LOC101733435
gene id: 8364:LOC101733435
uniprot id: A0A1B8Y8S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100488960
gene id: 8364:LOC100488960
uniprot id: A0A8J0QTQ7
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

8364:slc22a5
gene id: 8364:slc22a5
uniprot id: A0A6I8RD12
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

8364:pdf
gene id: 8364:pdf
uniprot id: Q6DIL5
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

8364:or8u9
gene id: 8364:or8u9
uniprot id: A0A8J0QVL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:harbi1
gene id: 8364:harbi1
uniprot id: F6XR96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8364:LOC116407990
gene id: 8364:LOC116407990
uniprot id: A0A8J1IXX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8364:ighmbp2
gene id: 8364:ighmbp2
uniprot id: A0A6I8Q959
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

8364:p2ry4
gene id: 8364:p2ry4
uniprot id: F6TLV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:c4orf33.1
gene id: 8364:c4orf33.1
uniprot id: Q28GP0
names: Similarity
messages: Belongs to the UPF0462 family.

8364:plin3
gene id: 8364:plin3
uniprot id: A0A8J0SCH8
uniprot id: A0A8J0T6C5
uniprot id: F6Y0T8
names: Similarity
messages: Belongs to the perilipin family.

8364:glo1
gene id: 8364:glo1
uniprot id: Q5BL69
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

8364:arg1
gene id: 8364:arg1
uniprot id: Q6DIU5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Homotrimer.

8364:LOC100490200
gene id: 8364:LOC100490200
uniprot id: A0A803JC55
names: Similarity
messages: Belongs to the MS4A family.

8364:rbm44
gene id: 8364:rbm44
uniprot id: A0A803K105
uniprot id: A0A8J0SX28
uniprot id: A0A8J1IU13
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100496183
gene id: 8364:LOC100496183
uniprot id: A0A8J0QX63
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

8364:kcnn2
gene id: 8364:kcnn2
uniprot id: A0A6I8RA55
uniprot id: A0A8J0SE91
names: Subcellular Location Annotation
messages: Membrane

8364:dact1
gene id: 8364:dact1
uniprot id: Q66KC9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dapper family.
messages: Cytoplasm
messages: Interacts with dbf4, dvl2 and tcf7l1.
messages: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and regulates the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. May also bind to and directly stimulate the activity of tcf7l1 (By similarity).
messages: Nucleus
messages: The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.

8364:or5i1
gene id: 8364:or5i1
uniprot id: A0A6I8SFH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC108646269
gene id: 8364:LOC108646269
uniprot id: A0A8J1J861
names: Subcellular Location Annotation
messages: Membrane

8364:antxrl
gene id: 8364:antxrl
uniprot id: A0A6I8R0Y5
uniprot id: A0A6I8RQC9
uniprot id: A0A6I8SNY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

8364:LOC116411018
gene id: 8364:LOC116411018
uniprot id: A0A8J1JL87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:plxnb3
gene id: 8364:plxnb3
uniprot id: F7B987
uniprot id: F7DG79
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8364:rbm42
gene id: 8364:rbm42
uniprot id: A0A1B8Y9Q2
uniprot id: A0A8J0SS81
uniprot id: Q66KL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM42 family.
messages: Cytoplasm
messages: May bind RNA.
messages: Nucleus

8364:ptpn2
gene id: 8364:ptpn2
uniprot id: A0A6I8QFS0
uniprot id: A0A8J0QRS9
uniprot id: A0A8J0R2A8
uniprot id: F6VS14
names: Similarity
messages: Belongs to the PP2C family.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

8364:nkx2-3
gene id: 8364:nkx2-3
uniprot id: A0A6I8Q8L6
names: Subcellular Location Annotation
messages: Nucleus

8364:reln
gene id: 8364:reln
uniprot id: A0A803KLF3
uniprot id: A0A8J0SHW2
uniprot id: A0A8J1J6R1
uniprot id: A0A8J1J957
uniprot id: B5DDZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

8364:ppp1r9al
gene id: 8364:ppp1r9al
uniprot id: A0A8J0QK06
uniprot id: A0A8J0R2U8
uniprot id: F6QQ09
names: Subcellular Location Annotation
messages: cytoskeleton

8364:LOC116408582
gene id: 8364:LOC116408582
uniprot id: A0A8J1J5X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:tsr3
gene id: 8364:tsr3
uniprot id: A0A8J0PJ71
uniprot id: A0A8J1IVN2
uniprot id: F6YBY2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:clasp1
gene id: 8364:clasp1
uniprot id: A1A5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLASP family.
messages: Interacts (via C-terminus) with clip1/clip-170, and cenpe.
messages: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules during anaphase. Plays a crucial role in chromatin-induced microtubule formation. May also act at microtubule minus ends. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) (By similarity).
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle
messages: trans-Golgi network

8364:LOC100494325
gene id: 8364:LOC100494325
uniprot id: A0A8J1IPX8
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:tgm4
gene id: 8364:tgm4
uniprot id: F7EB11
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8364:LOC108645503
gene id: 8364:LOC108645503
uniprot id: A0A8J1IZQ9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:galnt10
gene id: 8364:galnt10
uniprot id: Q0IIR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:eif4e
gene id: 8364:eif4e
uniprot id: Q28CE6
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

8364:LOC100380178
gene id: 8364:LOC100380178
uniprot id: A0A803KFB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:prdm13
gene id: 8364:prdm13
uniprot id: A0A6I8PSL5
names: Subcellular Location Annotation
messages: Nucleus

8364:mttp.2
gene id: 8364:mttp.2
uniprot id: A0A6I8PTB8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:synj1
gene id: 8364:synj1
uniprot id: A0A6I8R592
uniprot id: A0A6I8RPT3
uniprot id: A0A6I8S4C1
uniprot id: A0A6I8S4L6
uniprot id: A0A8J0T0W5
uniprot id: A0A8J1J700
uniprot id: F6ZWT4
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

8364:xrcc4
gene id: 8364:xrcc4
uniprot id: A0A803JCE9
uniprot id: A8WH10
uniprot id: B1H122
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

8364:kcnk13
gene id: 8364:kcnk13
uniprot id: F7CV21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8364:arf6
gene id: 8364:arf6
uniprot id: A0A803KKR5
uniprot id: F7CFW9
uniprot id: Q6P1V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

8364:ndst3
gene id: 8364:ndst3
uniprot id: B1H3K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

8364:kat2b
gene id: 8364:kat2b
uniprot id: F6W6T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus
messages: centrosome

8364:wdr76
gene id: 8364:wdr76
uniprot id: A0A8J0QJL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

8364:tmem216
gene id: 8364:tmem216
uniprot id: A0A8J1J5Z0
names: Subcellular Location Annotation
messages: Membrane

8364:itm2a
gene id: 8364:itm2a
uniprot id: Q6GL76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

8364:foxm1
gene id: 8364:foxm1
uniprot id: A0A6I8RBK3
uniprot id: A0A8J0T1R4
names: Subcellular Location Annotation
messages: Nucleus

8364:siah3
gene id: 8364:siah3
uniprot id: A0A6I8RL86
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

8364:LOC100485697
gene id: 8364:LOC100485697
uniprot id: A0A6I8SAW5
names: Subcellular Location Annotation
messages: Nucleus

8364:atp2b2
gene id: 8364:atp2b2
uniprot id: A0A6I8QF51
uniprot id: A0A6I8R566
uniprot id: A0A6I8RA99
uniprot id: A0A6I8REL0
uniprot id: A0A8J0QYR2
uniprot id: A0A8J0R0U6
uniprot id: A0A8J0R2Y5
uniprot id: A0A8J0R3L7
uniprot id: A0A8J1JGG5
uniprot id: A0A8J1JGG7
uniprot id: A0A8J1JIW5
uniprot id: A0A8J1JJZ2
uniprot id: F7B7G8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8364:prph2
gene id: 8364:prph2
uniprot id: F6YUE4
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

8364:nup50
gene id: 8364:nup50
uniprot id: Q28ID9
names: Subcellular Location Annotation
messages: nuclear pore complex

8364:gng4
gene id: 8364:gng4
uniprot id: Q0VFL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:LOC100490494
gene id: 8364:LOC100490494
uniprot id: A0A8J0ST81
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:xrn2
gene id: 8364:xrn2
uniprot id: Q28E00
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.

8364:LOC101733172
gene id: 8364:LOC101733172
uniprot id: A0A803JQW1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:lum
gene id: 8364:lum
uniprot id: Q640B1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

8364:MGC75582
gene id: 8364:MGC75582
uniprot id: P20399
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Actins are highly conserved proteins that are involved in various types of cell motility.
messages: Belongs to the actin family.
messages: Oxidation of Met-46 and Met-49 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization (By similarity).
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: Shows a different expression pattern to Xenopus laevis act2. Expressed in stage 24 and 42 embryos as well as in adult heart, but not adult skeletal muscle.
messages: The cardiac versus skeletal expression patterns of actins are probably sequence-dependent. For example, cardiac actins contain a Glu at position 3 of the mature peptide, whereas skeletal actins contain an Asp at this position.
messages: Xenopus contains at least three sarcomeric alpha actin genes that are preferentially expressed in either heart or skeletal muscle.
messages: cytoskeleton

8364:pdia4
gene id: 8364:pdia4
uniprot id: A0A6I8ST10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

8364:mysm1
gene id: 8364:mysm1
uniprot id: A0A6I8PW57
uniprot id: A0A6I8R7B0
uniprot id: A0A8J0SKV7
uniprot id: A0A8J0STF4
uniprot id: A0A8J1JFW4
uniprot id: A0A8J1JFW8
uniprot id: A0A8J1JIB0
names: Similarity
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.

8364:il10
gene id: 8364:il10
uniprot id: F7CQQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

8364:nhsl1
gene id: 8364:nhsl1
uniprot id: A0A6I8PZ07
uniprot id: A0A6I8Q262
uniprot id: A0A6I8S944
uniprot id: A0A8J0SDU4
uniprot id: A0A8J0SNK2
uniprot id: A0A8J0SNK7
uniprot id: A0A8J1JK90
uniprot id: B4F744
uniprot id: F7CRR8
uniprot id: L7N2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Belongs to the NHS family.
messages: Membrane

8364:emc2
gene id: 8364:emc2
uniprot id: Q5M7J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

8364:gsx2
gene id: 8364:gsx2
uniprot id: Q28CW5
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC101732654
gene id: 8364:LOC101732654
uniprot id: A0A8J0T412
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

8364:poglut2
gene id: 8364:poglut2
uniprot id: A0A803JTU0
names: Similarity
messages: Belongs to the KDELC family.

8364:dpm1
gene id: 8364:dpm1
uniprot id: Q5M793
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

8364:LOC100490214
gene id: 8364:LOC100490214
uniprot id: A0A8J0SXK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:nr1h2
gene id: 8364:nr1h2
uniprot id: Q0IHW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:amelx
gene id: 8364:amelx
uniprot id: A0A803KLF0
uniprot id: A9ULF1
names: Similarity
messages: Belongs to the amelogenin family.

8364:ptx
gene id: 8364:ptx
uniprot id: A0A6I8PYA8
uniprot id: A0A8J0QFD9
uniprot id: A9JTU7
uniprot id: A9UMU2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mfsd9
gene id: 8364:mfsd9
uniprot id: A0A6I8R811
names: Subcellular Location Annotation
messages: Membrane

8364:fam168b
gene id: 8364:fam168b
uniprot id: A0A6I8PQF6
uniprot id: A0A8J0SVQ4
uniprot id: A0A8J0SYV0
uniprot id: F7B2X0
uniprot id: Q0VFP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Basolateral cell membrane
messages: Belongs to the FAM168 family.
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Inhibitor of neuronal axonal outgrowth.
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: axon
messages: cilium
messages: perinuclear region

8364:sorl1
gene id: 8364:sorl1
uniprot id: F6Y0W9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

8364:med27
gene id: 8364:med27
uniprot id: Q5XHA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8364:LOC100489278
gene id: 8364:LOC100489278
uniprot id: A0A6I8SN18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:sdhc
gene id: 8364:sdhc
uniprot id: A9UM72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

8364:LOC105948004
gene id: 8364:LOC105948004
uniprot id: A0A8J1IWZ7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:myrfl
gene id: 8364:myrfl
uniprot id: A0A6I8RNA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

8364:fkbp6
gene id: 8364:fkbp6
uniprot id: A0A8J1J1D2
uniprot id: Q6P889
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

8364:gprc6a
gene id: 8364:gprc6a
uniprot id: A0A8J1JL14
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tnpo3
gene id: 8364:tnpo3
uniprot id: A0A6I8SNB2
uniprot id: A0A7D9NK70
names: Subcellular Location Annotation
messages: Cytoplasm

8364:xkr7
gene id: 8364:xkr7
uniprot id: A0A8J1IYH1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:canx
gene id: 8364:canx
uniprot id: Q6DK68
names: Similarity
messages: Belongs to the calreticulin family.

8364:serbp1
gene id: 8364:serbp1
uniprot id: A0A6I8RFI4
uniprot id: Q28FI2
uniprot id: Q6NVU1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:mdga2
gene id: 8364:mdga2
uniprot id: A0A6I8QW44
uniprot id: A0A8J1IP04
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101731560
gene id: 8364:LOC101731560
uniprot id: A0A8J0QZJ3
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC100486653
gene id: 8364:LOC100486653
uniprot id: A0A8J1IU90
names: Similarity
messages: Belongs to the histone H3 family.

8364:nrxn2
gene id: 8364:nrxn2
uniprot id: A0A5S6MW35
uniprot id: A0A6I8QZH3
uniprot id: A0A6I8RHG0
uniprot id: A0A6I8SA35
uniprot id: A0A6I8SQ19
uniprot id: A0A803J3I6
uniprot id: A0A8J0SJY7
uniprot id: A0A8J0SMR5
uniprot id: A0A8J0STB2
uniprot id: A0A8J0STB6
uniprot id: A0A8J0STC1
uniprot id: A0A8J0T0C4
uniprot id: A0A8J0T0D1
uniprot id: A0A8J0T2D3
uniprot id: A0A8J0T2R6
uniprot id: A0A8J0T2S2
uniprot id: A0A8J0T3K4
uniprot id: A0A8J1JFB6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:cox6b1
gene id: 8364:cox6b1
uniprot id: Q6DEQ9
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

8364:itpripl2
gene id: 8364:itpripl2
uniprot id: A0A8J0QHX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Belongs to the mab-21 family.
messages: Membrane

8364:egfl6
gene id: 8364:egfl6
uniprot id: A0A8J0SGQ3
uniprot id: F7A3J7
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gcgr
gene id: 8364:gcgr
uniprot id: A0A8J0R5D3
uniprot id: A0A8J0T493
uniprot id: F7EEJ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100495870
gene id: 8364:LOC100495870
uniprot id: A0A1B8Y816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:cd164l2
gene id: 8364:cd164l2
uniprot id: A0A8J0SYV2
uniprot id: A0A8J0T230
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

8364:hebp1
gene id: 8364:hebp1
uniprot id: Q6DJ66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEBP family.
messages: Cytoplasm
messages: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
messages: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity).
messages: Monomer.

8364:hsp90aa1.1
gene id: 8364:hsp90aa1.1
uniprot id: A0A6I8Q4N0
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8364:gal3st4.3
gene id: 8364:gal3st4.3
uniprot id: A0A803JFV3
uniprot id: A0A8J1JBX8
uniprot id: A0A8J1JFE6
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

8364:col4a2
gene id: 8364:col4a2
uniprot id: F6TF09
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

8364:rgs7bp
gene id: 8364:rgs7bp
uniprot id: A0A6I8QX62
uniprot id: F6Y1J5
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

8364:rftn1
gene id: 8364:rftn1
uniprot id: A8WH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

8364:crp.2
gene id: 8364:crp.2
uniprot id: A0A8J0PFZ5
uniprot id: Q5I011
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:rhot1
gene id: 8364:rhot1
uniprot id: A0A6I8R4Y7
uniprot id: A0A6I8RI68
uniprot id: A0A8J1IX87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

8364:sec62
gene id: 8364:sec62
uniprot id: B2GUQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:slc17a9
gene id: 8364:slc17a9
uniprot id: A0A8J1J0B5
names: Subcellular Location Annotation
messages: Membrane

8364:slc30a3
gene id: 8364:slc30a3
uniprot id: A0A8J0QZG5
uniprot id: F6X5K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8364:fabp6
gene id: 8364:fabp6
uniprot id: F6SPQ9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8364:LOC100495552
gene id: 8364:LOC100495552
uniprot id: A0A1B8XXY9
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8364:wnt2
gene id: 8364:wnt2
uniprot id: A0A6I8R7P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:ube4a
gene id: 8364:ube4a
uniprot id: A0A8J0ST23
uniprot id: F6VBF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

8364:cdh18
gene id: 8364:cdh18
uniprot id: F7BTR8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8364:LOC116408397
gene id: 8364:LOC116408397
uniprot id: A0A8J1IZL2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116409810
gene id: 8364:LOC116409810
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC100493932
gene id: 8364:LOC100493932
uniprot id: A0A8J0QQN8
names: Similarity
messages: Belongs to the RNase H family.

8364:LOC116410927
gene id: 8364:LOC116410927
uniprot id: A0A803JU38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

8364:gga1
gene id: 8364:gga1
uniprot id: Q28E38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

8364:kif5c
gene id: 8364:kif5c
uniprot id: A0A6I8RVQ6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:rab3gap2
gene id: 8364:rab3gap2
uniprot id: A0A6I8QAN9
uniprot id: A0A6I8SEH4
uniprot id: B1WB62
uniprot id: L7MUK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm
messages: Membrane

8364:napa
gene id: 8364:napa
uniprot id: Q5M8J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

8364:wwc2
gene id: 8364:wwc2
uniprot id: Q6DJR2
names: Similarity
messages: Belongs to the WWC family.

8364:pklr
gene id: 8364:pklr
uniprot id: A0A8J1IN53
uniprot id: A0A8J1IN54
uniprot id: A0A8J1IQI2
uniprot id: A0A8J1IR81
names: Similarity
messages: Belongs to the pyruvate kinase family.

8364:alg6
gene id: 8364:alg6
uniprot id: Q5I096
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:nab1
gene id: 8364:nab1
uniprot id: A0A803J6S7
uniprot id: B1H0X5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

8364:fam131b
gene id: 8364:fam131b
uniprot id: A0A8J1JUF1
uniprot id: A0A8J1JWV3
uniprot id: A0A8J1JY93
names: Similarity
messages: Belongs to the FAM131 family.

8364:igf1
gene id: 8364:igf1
uniprot id: F6V1C3
uniprot id: F7B0G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carotenoid oxygenase family.
messages: Belongs to the insulin family.
messages: Secreted

8364:ocm4.2
gene id: 8364:ocm4.2
uniprot id: Q28HK5
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8364:mcoln3
gene id: 8364:mcoln3
uniprot id: A0A8J1JDK1
uniprot id: A0A8J1JDK7
uniprot id: Q28DB4
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

8364:LOC116407689
gene id: 8364:LOC116407689
uniprot id: A0A8J1IUW7
names: Subcellular Location Annotation
messages: Nucleus

8364:wnt11b
gene id: 8364:wnt11b
uniprot id: Q28J82
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Wnt family.
messages: Glycosylation is required for protein secretion.
messages: Homodimer. Secreted homodimers form a complex with wnt5a homodimers; tyrosine sulfation of both wnt11 and wnt5a by tpst1 is required for this interaction. Interacts with the transmembrane receptor fzd7/fz7. Interacts with lrp6 and ryk. Interacts with tdgf1/frl1. Interacts weakly with frzb1 and strongly with frzb2/crescent. Interaction with frzb2/crescent antagonizes wnt11 function in the neuroectoderm, but enhances it in mesodermal tissue (By similarity).
messages: Ligand for the frizzled7 transmembrane receptor. Primarily acts via non-canonical Wnt pathways mediated by either Ca(2+) and PKC, or by JNK and dvl2/dsh. Depending on the cellular context, can also signal via the canonical Wnt pathway mediated by beta-catenin and dvl2/dsh. May also inhibit canonical Wnt signaling. Maternally initiates dorsal/ventral axis formation by a canonical route, which signals via lrp6. In a complex with wnt5a, activates the canonical and non-canonical processes involved in axis formation. In the non-canonical pathway, acts through fzd7/fz7 to induce phosphorylation of dvl2/dsh. Signals through a non-canonical Wnt pathway to regulate convergent extension movements during gastrulation. Interactions with the secreted Wnt antagonist sfrp5 to coordinate foregut development, acting via a non-canonical wnt pathway whereby sfrp5 restricts wnt11b activity to prevent inappropriate foregut formation. Mediates cardiogenesis via non-canonical Wnt signaling involving JNK-activation and PKC. Acts redundantly with wnt11/wnt11r during pronephros induction (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Xenopus and other lower vertebrates contain duplicated wnt11 genes (wnt11 and wnt11b) resulting from an ancient gene duplication event, but the second copy has since been lost in mammals. In addition, X.tropicalis has two very similar wnt11b genes suggesting a further recent duplication event.
messages: extracellular matrix

8364:LOC100485303
gene id: 8364:LOC100485303
uniprot id: A0A6I8SIP7
names: Similarity
messages: Belongs to the FBPase class 1 family.

8364:rasgef1a
gene id: 8364:rasgef1a
uniprot id: A0JM95
names: Function
messages: Guanine nucleotide exchange factor (GEF) with specificity for rap2a and other Ras family proteins (in vitro). Plays a role in cell migration (By similarity).

8364:LOC116409478
gene id: 8364:LOC116409478
uniprot id: A0A8J1J801
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116411595
gene id: 8364:LOC116411595
uniprot id: A0A8J1JSL7
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:dyrk1a.2
gene id: 8364:dyrk1a.2
uniprot id: A0A6I8PVJ2
uniprot id: A0A6I8SBU4
uniprot id: A0A8J0SPZ1
uniprot id: B1H2N4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

8364:rnf152
gene id: 8364:rnf152
uniprot id: A0A6I8SQJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

8364:capn8.5
gene id: 8364:capn8.5
uniprot id: A0A803KC39
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:LOC100496467
gene id: 8364:LOC100496467
uniprot id: A0A8J0QR79
names: Subcellular Location Annotation
messages: Membrane

8364:mrpl34
gene id: 8364:mrpl34
uniprot id: A0A6I8Q561
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

8364:cenpn
gene id: 8364:cenpn
uniprot id: F6RYV3
uniprot id: Q5XGF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-N/CHL4 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere

8364:slc29a1
gene id: 8364:slc29a1
uniprot id: A0A803JJS8
uniprot id: Q5FW31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

8364:nlgn3
gene id: 8364:nlgn3
uniprot id: A0A6I8RCY9
uniprot id: A0A803K1S7
uniprot id: D2X2K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8364:slc35e3
gene id: 8364:slc35e3
uniprot id: A0A6I8PTL3
uniprot id: F7EMA9
names: Subcellular Location Annotation
messages: Membrane

8364:slc44a1
gene id: 8364:slc44a1
uniprot id: A0A8J0QZK2
uniprot id: F6WD25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

8364:pex7
gene id: 8364:pex7
uniprot id: Q28E40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

8364:ttyh1
gene id: 8364:ttyh1
uniprot id: Q0V9V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Probable chloride channel.

8364:tubz1
gene id: 8364:tubz1
uniprot id: A0A6I8RNG6
uniprot id: A0A8J1JQ43
uniprot id: A0A8J1JSK8
uniprot id: F7D152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

8364:traf5
gene id: 8364:traf5
uniprot id: A0A8J1JMU4
uniprot id: F6VTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8364:vps13d
gene id: 8364:vps13d
uniprot id: A0A6I8QVF3
uniprot id: A0A6I8RAW6
names: Similarity
messages: Belongs to the VPS13 family.

8364:usp15
gene id: 8364:usp15
uniprot id: A0A8J0SHV6
uniprot id: A0A8J1J938
uniprot id: F6Z5C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs, thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of tgfbr1, leading to an enhanced TGF-beta signal. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Involved in endosome organization by mediating deubiquitination of rnf26 target(s), releasing vesicles that are restrained in the perinuclear region.
messages: Nucleus

8364:clp1
gene id: 8364:clp1
uniprot id: Q66JK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by dicer1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

8364:LOC101734426
gene id: 8364:LOC101734426
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:LOC101731190
gene id: 8364:LOC101731190
uniprot id: A0A6I8PQY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:pglyrp1
gene id: 8364:pglyrp1
uniprot id: A0A803JNK5
uniprot id: Q5FVY1
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

8364:nuf2
gene id: 8364:nuf2
uniprot id: B0JYZ0
names: Similarity
messages: Belongs to the NUF2 family.

8364:satb2
gene id: 8364:satb2
uniprot id: A0A6I8RC36
uniprot id: A0A6I8RFA7
uniprot id: A0A8J0QQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8364:sec24c
gene id: 8364:sec24c
uniprot id: A0A6I8QZX3
uniprot id: A0A6I8SV10
uniprot id: A0A7D9NMF2
uniprot id: A0A8J0QFY7
uniprot id: A0A8J1JSX4
uniprot id: A0A8J1JWQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8364:steap2
gene id: 8364:steap2
uniprot id: F6V3S0
uniprot id: F6YGT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the STEAP family.
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

8364:pglyrp1-like.1
gene id: 8364:pglyrp1-like.1
uniprot id: A0A803JPG3
uniprot id: Q5BKE6
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

8364:ascc3
gene id: 8364:ascc3
uniprot id: A0A6I8R8D3
uniprot id: A0A8J0QHF1
names: Similarity
messages: Belongs to the helicase family.

8364:ero1a
gene id: 8364:ero1a
uniprot id: A0A8J0SVG6
uniprot id: B1H1F9
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: Enzyme activity is tightly regulated to prevent the accumulation of reactive oxygen species in the endoplasmic reticulum. Reversibly down-regulated by the formation of disulfide bonds between the active site Cys-99 and Cys-138, and between Cys-104 and Cys-109. Glutathione may be required to regulate its activity in the endoplasmic reticulum (By similarity).
messages: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the folding of immunoglobulins (By similarity).
messages: Predominantly monomer. May function both as a monomer and a homodimer (By similarity).
messages: The Cys-99/Cys-104 and Cys-401/Cys-404 disulfide bonds constitute the redox-active center. The Cys-99/Cys-104 disulfide bond may accept electron from protein disulfide isomerase (PDI) and funnel them to the active site disulfide Cys-401/Cys-404 (By similarity).

8364:hbg2
gene id: 8364:hbg2
uniprot id: Q6DJ70
names: Similarity
messages: Belongs to the globin family.

8364:LOC100491441
gene id: 8364:LOC100491441
uniprot id: A0A8J0QNJ2
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:alas2
gene id: 8364:alas2
uniprot id: A0A803KIW4
uniprot id: F6PI13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

8364:bap1
gene id: 8364:bap1
uniprot id: Q66JB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C12 family. BAP1 subfamily.
messages: Component of the PR-DUB complex.
messages: Cytoplasm
messages: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).
messages: Nucleus

8364:LOC116409550
gene id: 8364:LOC116409550
uniprot id: A0A8J1J895
names: Subcellular Location Annotation
messages: Membrane

8364:fgf8
gene id: 8364:fgf8
uniprot id: A0A803KIA6
uniprot id: A0A8J0STN2
uniprot id: F6V070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

8364:kcnj11
gene id: 8364:kcnj11
uniprot id: F7D6C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

8364:pkn2
gene id: 8364:pkn2
uniprot id: F7CM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

8364:nxpe3l.5
gene id: 8364:nxpe3l.5
uniprot id: A0A6I8QBD1
uniprot id: A0A8J0S5X0
uniprot id: A0A8J0SAA1
names: Similarity
messages: Belongs to the NXPE family.

8364:LOC116411041
gene id: 8364:LOC116411041
uniprot id: A0A8J1JLB7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:crybg3
gene id: 8364:crybg3
uniprot id: A0A8J1J3K7
uniprot id: A0A8J1J3K8
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:fer
gene id: 8364:fer
uniprot id: A0A6I8QYV4
uniprot id: F6YFH6
uniprot id: Q28DZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: cytoskeleton

8364:xt6l
gene id: 8364:xt6l
uniprot id: D3WKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

8364:map2k6
gene id: 8364:map2k6
uniprot id: Q6GL46
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:gjb7
gene id: 8364:gjb7
uniprot id: F6W3E8
uniprot id: F6ZMD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: gap junction

8364:dbr1
gene id: 8364:dbr1
uniprot id: Q6P886
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function.
messages: Nucleus

8364:ddx52
gene id: 8364:ddx52
uniprot id: B1WAX3
uniprot id: F7BCP5
uniprot id: F7EIL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
messages: Cytoplasm
messages: Nucleus

8364:s1pr5
gene id: 8364:s1pr5
uniprot id: B1WAQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:vamp4
gene id: 8364:vamp4
uniprot id: Q28DY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

8364:LOC100145779
gene id: 8364:LOC100145779
uniprot id: A0A8J1IYE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8364:dedd2
gene id: 8364:dedd2
uniprot id: F7B8J3
uniprot id: F7E003
uniprot id: Q0P4U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: nucleolus

8364:LOC116412116
gene id: 8364:LOC116412116
uniprot id: A0A6I8QQA8
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:nefh
gene id: 8364:nefh
uniprot id: A0A6I8QND8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon
messages: cytoskeleton

8364:LOC100486056
gene id: 8364:LOC100486056
uniprot id: F6WUR5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC101733362
gene id: 8364:LOC101733362
uniprot id: F6RFQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sparc
gene id: 8364:sparc
uniprot id: Q6P2X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

8364:gdi2
gene id: 8364:gdi2
uniprot id: Q6DK67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

8364:LOC116409475
gene id: 8364:LOC116409475
uniprot id: A0A8J1J7Z6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:myt1l
gene id: 8364:myt1l
uniprot id: A0A6I8QSG5
uniprot id: A0A6I8RJ62
uniprot id: A0A8J1JLF1
uniprot id: A0A8J1JLF6
uniprot id: A0A8J1JLG0
uniprot id: A0A8J1JLG3
uniprot id: A0A8J1JLG4
uniprot id: A0A8J1JLG8
uniprot id: A0A8J1JNV3
uniprot id: A0A8J1JQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

8364:wdr61
gene id: 8364:wdr61
uniprot id: Q6PBD6
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PAF1 complex, which at least consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (By similarity). The PAF1 complex interacts with PHF5A (By similarity).
messages: Cytoplasm
messages: Nucleus

8364:rnft1
gene id: 8364:rnft1
uniprot id: B7ZTC8
uniprot id: Q28GL3
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:thoc2
gene id: 8364:thoc2
uniprot id: A0A6I8QXJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

8364:nek7
gene id: 8364:nek7
uniprot id: A0A8J0SKJ6
uniprot id: Q0IHX5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:arl6ip4
gene id: 8364:arl6ip4
uniprot id: A0A6I8PZE4
uniprot id: B0BMG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: nucleolus

8364:dnajc16
gene id: 8364:dnajc16
uniprot id: A0A803KFK5
names: Subcellular Location Annotation
messages: Membrane

8364:ttc21b
gene id: 8364:ttc21b
uniprot id: A0A6I8QBQ5
uniprot id: A0A6I8SNT2
names: Similarity
messages: Belongs to the TTC21 family.

8364:LOC116409470
gene id: 8364:LOC116409470
uniprot id: A0A8J1JAE1
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: Membrane raft
messages: Secreted

8364:LOC108646250
gene id: 8364:LOC108646250
uniprot id: A0A8J1JE98
names: Subcellular Location Annotation
messages: Secreted

8364:LOC100497166
gene id: 8364:LOC100497166
uniprot id: A0A8J1IS97
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pamr1
gene id: 8364:pamr1
uniprot id: Q6DIV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 667 which is replaced by a Thr, suggesting that it has no protease activity.
messages: Belongs to the peptidase S1 family.
messages: May play a role in regeneration of skeletal muscle.
messages: Secreted

8364:LOC100495429
gene id: 8364:LOC100495429
uniprot id: A0A803KLB9
uniprot id: A0A8J0T5Y1
uniprot id: F7DW62
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

8364:glrb
gene id: 8364:glrb
uniprot id: Q0VA59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

8364:LOC100491119
gene id: 8364:LOC100491119
uniprot id: A0A8J0R1I7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:carm1
gene id: 8364:carm1
uniprot id: A0A8J0QZ67
uniprot id: F7EG74
names: Subcellular Location Annotation
messages: Nucleus

8364:ces3.1
gene id: 8364:ces3.1
uniprot id: B0BM77
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:LOC100489792
gene id: 8364:LOC100489792
uniprot id: F6RVG6
uniprot id: F6THP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Membrane
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

8364:igfbp4
gene id: 8364:igfbp4
uniprot id: A0A803K6D4
uniprot id: A0A8J1J0M4
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:cadm3
gene id: 8364:cadm3
uniprot id: A0A6I8QUF1
uniprot id: A0A6I8RHG9
names: Similarity
messages: Belongs to the nectin family.

8364:c18orf32
gene id: 8364:c18orf32
uniprot id: Q28I13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0729 family.
messages: Endoplasmic reticulum
messages: Lipid droplet

8364:atp13a5l.2
gene id: 8364:atp13a5l.2
uniprot id: A0A7D9NJR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8364:kcnj12
gene id: 8364:kcnj12
uniprot id: A0A803K0G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Cell membrane
messages: Membrane

8364:camta2
gene id: 8364:camta2
uniprot id: A0A803KFN0
uniprot id: F6RIL2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.
messages: Nucleus

8364:elp4
gene id: 8364:elp4
uniprot id: A0A6I8QCJ1
uniprot id: A0A803K7V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

8364:snx10
gene id: 8364:snx10
uniprot id: A0A6I8PW12
uniprot id: Q5XGD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

8364:LOC100489067
gene id: 8364:LOC100489067
uniprot id: F7A485
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CD36 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft

8364:LOC100495467
gene id: 8364:LOC100495467
uniprot id: A0A8J1IQU4
uniprot id: A0A8J1IQV6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8364:acbd5
gene id: 8364:acbd5
uniprot id: A0A6I8PUV6
uniprot id: A0A803K436
uniprot id: Q640U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity).
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

8364:tmbim1
gene id: 8364:tmbim1
uniprot id: Q569D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8364:pdcl
gene id: 8364:pdcl
uniprot id: B7ZSW5
names: Similarity
messages: Belongs to the phosducin family.

8364:cenpk
gene id: 8364:cenpk
uniprot id: F6YQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

8364:kcnc2
gene id: 8364:kcnc2
uniprot id: A0A6I8PTR3
uniprot id: A0A6I8QNY2
uniprot id: A0A8J0T183
names: Subcellular Location Annotation
messages: Membrane

8364:adk
gene id: 8364:adk
uniprot id: A0A6I8SMV1
uniprot id: Q28IY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

8364:dennd6a
gene id: 8364:dennd6a
uniprot id: A0A8J1JGW4
uniprot id: F6S962
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

8364:hba1
gene id: 8364:hba1
uniprot id: P07428
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

8364:tmem17l
gene id: 8364:tmem17l
uniprot id: Q5HZD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM17 family.
messages: Part of the tectonic-like complex (also named B9 complex).
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: cilium membrane

8364:smarcal1
gene id: 8364:smarcal1
uniprot id: A0A8J1ISP2
uniprot id: Q0P4U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity).
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

8364:tmem205
gene id: 8364:tmem205
uniprot id: Q28GF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

8364:clcn7
gene id: 8364:clcn7
uniprot id: A0A6I8PP83
uniprot id: Q28C02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

8364:tnfrsf21
gene id: 8364:tnfrsf21
uniprot id: F6UZS5
uniprot id: Q0IHT5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:med13l
gene id: 8364:med13l
uniprot id: A0A7D9N0D0
uniprot id: A0A8J0QV12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:il16
gene id: 8364:il16
uniprot id: A0A6I8SKD0
uniprot id: A0A803JJ98
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

8364:LOC101734217
gene id: 8364:LOC101734217
uniprot id: A0A8J0R608
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:hjv
gene id: 8364:hjv
uniprot id: A0A6I8RG06
uniprot id: F7B703
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM53 family.
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8364:LOC116408580
gene id: 8364:LOC116408580
uniprot id: A0A8J1J2G8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101733404
gene id: 8364:LOC101733404
uniprot id: A0A803JHL8
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

8364:irx2
gene id: 8364:irx2
uniprot id: Q66IK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Probably dispensable for pronephric kidney development.
messages: Belongs to the TALE/IRO homeobox family.
messages: Expressed in the neural plate in overlapping patterns with other irx members, which all share an anterior border of expression. Also expressed in the placodes. Broadly expressed in the tailbud rhombencephalon (hindbrain). Outside the nervous system and at tailbud stages, expressed in the developing otic vesicle, branchial arches, prospective heart region and pronephros.
messages: Nucleus

8364:tcp1
gene id: 8364:tcp1
uniprot id: A0A6I8T009
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

8364:il10rb
gene id: 8364:il10rb
uniprot id: D2DJQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

8364:celsr2
gene id: 8364:celsr2
uniprot id: A0A6I8PZ44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

8364:vps33a
gene id: 8364:vps33a
uniprot id: A0A6I8R453
uniprot id: Q28F93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8364:sdc3
gene id: 8364:sdc3
uniprot id: A0A6I8PYW4
uniprot id: A0A8J0QS80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

8364:gjb2
gene id: 8364:gjb2
uniprot id: Q28ED4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:pfn2
gene id: 8364:pfn2
uniprot id: B3DLT3
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

8364:psmd7
gene id: 8364:psmd7
uniprot id: F6VJR0
names: Similarity
messages: Belongs to the peptidase M67A family.

8364:clcf1
gene id: 8364:clcf1
uniprot id: Q0VFC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: Belongs to the IL-6 superfamily.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm
messages: Secreted

8364:meis3
gene id: 8364:meis3
uniprot id: A0A8J0SVA0
uniprot id: Q6DIF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A caudalizing protein which is required to pattern the anterior/posterior (A/P) axis during central nervous system (CNS) formation. Inhibits anterior neural expression and acts as a transcriptional activator to induce posterior neural gene expression. Maintains a proper A/P balance required for hindbrain formation by activating the FGF/MAPK pathway, which modulates the planar cell polarity (PCP) pathway. Interacts with retinoid signaling during hindbrain patterning (By similarity).
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

8364:LOC100495578
gene id: 8364:LOC100495578
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:dsel
gene id: 8364:dsel
uniprot id: A0A803JE89
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

8364:sin3a
gene id: 8364:sin3a
uniprot id: A0A8J0T1E6
uniprot id: F6TAI6
names: Subcellular Location Annotation
messages: Nucleus

8364:zpr1
gene id: 8364:zpr1
uniprot id: F7AAH1
names: Similarity
messages: Belongs to the ZPR1 family.

8364:tmtops.2
gene id: 8364:tmtops.2
uniprot id: F7EFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8364:LOC100490428
gene id: 8364:LOC100490428
uniprot id: A0A8J0QRK7
names: Similarity
messages: Belongs to the dysbindin family.

8364:LOC105947131
gene id: 8364:LOC105947131
uniprot id: B5DDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:hyls1
gene id: 8364:hyls1
uniprot id: A0A6I8RYD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

8364:ndufb5
gene id: 8364:ndufb5
uniprot id: F6V6L5
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.

8364:LOC108648286
gene id: 8364:LOC108648286
uniprot id: A0A8J1IT55
names: Subcellular Location Annotation
messages: Membrane

8364:manea
gene id: 8364:manea
uniprot id: A0A803K943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:slc19a3
gene id: 8364:slc19a3
uniprot id: Q6DIK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
messages: Membrane

8364:LOC100489483
gene id: 8364:LOC100489483
uniprot id: F6ZBV4
names: Similarity
messages: Belongs to the PIAS family.

8364:pias3
gene id: 8364:pias3
uniprot id: A0A8J1IKV4
uniprot id: B0JZD8
uniprot id: F6ZBV4
names: Similarity
messages: Belongs to the PIAS family.

8364:prkaca
gene id: 8364:prkaca
uniprot id: A0A6I8QAJ9
uniprot id: A0A6I8SXB5
uniprot id: Q28GZ8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

8364:fktn
gene id: 8364:fktn
uniprot id: A4II65
names: Similarity
messages: Belongs to the LicD transferase family.

8364:mtrf1l
gene id: 8364:mtrf1l
uniprot id: F6YR07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

8364:nlgn4x
gene id: 8364:nlgn4x
uniprot id: A0A803JR87
uniprot id: F6SZI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8364:trex2
gene id: 8364:trex2
uniprot id: A0A6I8S0Y4
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

8364:ablim3
gene id: 8364:ablim3
uniprot id: A0A6I8PXT5
uniprot id: A0A8J0QXN0
uniprot id: A0A8J0QZQ9
uniprot id: A0A8J0SJL4
uniprot id: A0A8J0SJM6
uniprot id: A0A8J0T157
uniprot id: A0A8J0T2F3
uniprot id: A0A8J1J9X8
uniprot id: A0A8J1J9Y6
uniprot id: A0A8J1JDG5
names: Subcellular Location Annotation
messages: Cytoplasm

8364:elf1
gene id: 8364:elf1
uniprot id: Q0IHW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:exoc1
gene id: 8364:exoc1
uniprot id: A0A8J0SEL6
uniprot id: A0A8J1J188
uniprot id: A0A8J1J3M0
uniprot id: B1H3J1
uniprot id: F6ZY35
names: Similarity
messages: Belongs to the SEC3 family.

8364:hikeshi
gene id: 8364:hikeshi
uniprot id: A4IGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a specific nuclear import carrier for hsp70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound hsp70 proteins into the nucleus. hsp70 proteins import is required to protect cells from heat shock damages (By similarity).
messages: Belongs to the OPI10 family.
messages: Nucleus
messages: cytosol

8364:parvg
gene id: 8364:parvg
uniprot id: A0A6I8SRE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

8364:tbc1d23
gene id: 8364:tbc1d23
uniprot id: A0A6I8QJF3
uniprot id: A0A6I8S0I7
names: Subcellular Location Annotation
messages: trans-Golgi network

8364:cenpi
gene id: 8364:cenpi
uniprot id: F7AMT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

8364:cmas
gene id: 8364:cmas
uniprot id: Q0E672
names: Similarity
messages: Belongs to the CMP-NeuNAc synthase family.

8364:gipc1
gene id: 8364:gipc1
uniprot id: A0A8J0S5M3
uniprot id: Q5M7S8
names: Similarity
messages: Belongs to the GIPC family.

8364:actg1
gene id: 8364:actg1
uniprot id: Q6P378
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylated at His-73 by SETD3.
messages: Oxidation of Met-44 and Met-47 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: cytoskeleton

8364:LOC733561
gene id: 8364:LOC733561
uniprot id: F7AX35
names: Similarity
messages: Belongs to the histone H2B family.

8364:ankrd13b
gene id: 8364:ankrd13b
uniprot id: A0A6I8QBE4
uniprot id: A0A8J0S5V6
uniprot id: A0A8J0SA85
uniprot id: A0A8J0SBV5
uniprot id: A0A8J0SCK8
uniprot id: A4IIS1
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

8364:cyp1d1
gene id: 8364:cyp1d1
uniprot id: A0A6I8Q0C1
uniprot id: A0A803K2E8
uniprot id: B1H1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8364:LOC100485506
gene id: 8364:LOC100485506
uniprot id: A0A8J0SEC4
names: Subcellular Location Annotation
messages: Membrane

8364:epg5
gene id: 8364:epg5
uniprot id: A0A6I8QDY0
names: Similarity
messages: Belongs to the EPG5 family.

8364:clip1
gene id: 8364:clip1
uniprot id: A0A6I8Q6P6
uniprot id: A0A6I8R6X2
uniprot id: A0A6I8RJT9
uniprot id: A0A8J0SP12
uniprot id: A0A8J1JD64
uniprot id: A0A8J1JD79
uniprot id: A0A8J1JDA6
uniprot id: A0A8J1JDH7
uniprot id: A0A8J1JFI6
uniprot id: A0A8J1JFW7
uniprot id: A0A8J1JG58
uniprot id: A0A8J1JGT8
uniprot id: A0A8J1JGV7
uniprot id: A0A8J1JGZ7
names: Subcellular Location Annotation
messages: cytoskeleton

8364:LOC105946680
gene id: 8364:LOC105946680
uniprot id: A0A8J0SHA5
names: Similarity
messages: Belongs to the cyclin family.

8364:erlec1
gene id: 8364:erlec1
uniprot id: A0A8J0SKZ0
uniprot id: Q6NVN2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

8364:tshz3
gene id: 8364:tshz3
uniprot id: A0A803JLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

8364:tyms
gene id: 8364:tyms
uniprot id: Q0IHX3
names: Similarity
messages: Belongs to the thymidylate synthase family.

8364:krt18.1
gene id: 8364:krt18.1
uniprot id: Q6P864
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).
messages: Phosphorylated.
messages: Proteolytically cleaved by caspases during epithelial cell apoptosis.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
messages: When phosphorylated, plays a role in filament reorganization.

8364:ctla4
gene id: 8364:ctla4
uniprot id: A0A6I8RD47
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

8364:ltbp1
gene id: 8364:ltbp1
uniprot id: A0A6I8Q6R6
uniprot id: A0A6I8QAR3
uniprot id: A0A8J0R1S8
uniprot id: A0A8J1JJ04
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:apom
gene id: 8364:apom
uniprot id: A0A8J0STN0
uniprot id: A4IGK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

8364:pcgf1
gene id: 8364:pcgf1
uniprot id: Q28H21
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a PRC1-like complex.
messages: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
messages: Nucleus

8364:hgs
gene id: 8364:hgs
uniprot id: A0A803KIY0
uniprot id: A0A8J0SIR9
uniprot id: A0A8J0SSH0
uniprot id: A0A8J0STG9
uniprot id: A0A8J0STU6
uniprot id: B4F6T1
uniprot id: B7ZUS7
uniprot id: Q28CS1
names: Subcellular Location Annotation
messages: Early endosome membrane

8364:jmy
gene id: 8364:jmy
uniprot id: A8E4X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.
messages: Belongs to the JMY family.
messages: Cytoplasmic vesicle
messages: Endomembrane system
messages: Nucleus
messages: autophagosome membrane
messages: cytoskeleton

8364:snx2
gene id: 8364:snx2
uniprot id: A0A6I8QDK8
uniprot id: A0A6I8RN61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

8364:parp12
gene id: 8364:parp12
uniprot id: A0A8J1JCR5
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:LOC100490837
gene id: 8364:LOC100490837
uniprot id: A0A8J0R8C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Membrane

8364:LOC116406903
gene id: 8364:LOC116406903
uniprot id: A0A8J1ISX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

8364:htr1a
gene id: 8364:htr1a
uniprot id: F7E4L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cnn2
gene id: 8364:cnn2
uniprot id: Q6NVQ5
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

8364:crispld2
gene id: 8364:crispld2
uniprot id: Q4V9Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISP family.
messages: Promotes matrix assembly.
messages: Secreted

8364:mmp23b
gene id: 8364:mmp23b
uniprot id: A0A6I8SRJ3
uniprot id: A0A8J1JZU1
names: Caution
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cntnap1
gene id: 8364:cntnap1
uniprot id: A2RUV2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

8364:ap4s1
gene id: 8364:ap4s1
uniprot id: Q28GN6
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

8364:rad54l2
gene id: 8364:rad54l2
uniprot id: A4IHD2
uniprot id: F7C1Q9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors.
messages: Nucleus

8364:crygdl.7
gene id: 8364:crygdl.7
uniprot id: A0A8J0SAG8
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:ctnnbip1
gene id: 8364:ctnnbip1
uniprot id: Q66IL2
names: Similarity
messages: Belongs to the CTNNBIP1 family.

8364:c10orf53
gene id: 8364:c10orf53
uniprot id: A0A6I8SNB4
uniprot id: A0A8J0R5I2
names: Similarity
messages: Belongs to the UPF0728 family.

8364:smim7
gene id: 8364:smim7
uniprot id: Q6P317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM7 family.
messages: Membrane

8364:wnt7a
gene id: 8364:wnt7a
uniprot id: A0A803JYV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:slc25a28
gene id: 8364:slc25a28
uniprot id: A0JM88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:c3h12orf75
gene id: 8364:c3h12orf75
uniprot id: A0A8J0QXS1
uniprot id: A0A8J0QZV3
uniprot id: A0A8J0R207
uniprot id: A0A8J0SJR1
names: Similarity
messages: Belongs to the OCC1 family.

8364:slc39a1
gene id: 8364:slc39a1
uniprot id: A0A803KIT7
uniprot id: Q28DI8
names: Subcellular Location Annotation
messages: Membrane

8364:stard3nl
gene id: 8364:stard3nl
uniprot id: B3DLA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8364:LOC733566
gene id: 8364:LOC733566
uniprot id: L7MUK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

8364:rock1
gene id: 8364:rock1
uniprot id: A0A6I8SAS2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

8364:zhx1
gene id: 8364:zhx1
uniprot id: F6SU96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

8364:f11r
gene id: 8364:f11r
uniprot id: Q66JI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

8364:kdelr1
gene id: 8364:kdelr1
uniprot id: Q6P257
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).

8364:msmb.3
gene id: 8364:msmb.3
uniprot id: A0A8J0QLN2
uniprot id: F6QYB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8364:ppp3r1
gene id: 8364:ppp3r1
uniprot id: Q6VN50
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

8364:kcnab3
gene id: 8364:kcnab3
uniprot id: A0A8J1J7P2
uniprot id: Q0IIY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

8364:cdkl4
gene id: 8364:cdkl4
uniprot id: A0A8J1IVH8
uniprot id: A0A8J1IW93
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:tlx3
gene id: 8364:tlx3
uniprot id: Q28CD6
names: Subcellular Location Annotation
messages: Nucleus

8364:acad10
gene id: 8364:acad10
uniprot id: F7ALM6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8364:rmdn2
gene id: 8364:rmdn2
uniprot id: Q0P4W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMDN family.
messages: Membrane

8364:tmem218
gene id: 8364:tmem218
uniprot id: B0JYX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

8364:c19orf53
gene id: 8364:c19orf53
uniprot id: A0A6I8R3B7
names: Similarity
messages: Belongs to the UPF0390 family.

8364:emc1
gene id: 8364:emc1
uniprot id: A0A803JF46
uniprot id: F6TUQ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC105945396
gene id: 8364:LOC105945396
uniprot id: A0A8J0SBM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100491634
gene id: 8364:LOC100491634
uniprot id: A0A803JSH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

8364:LOC100490227
gene id: 8364:LOC100490227
uniprot id: A0A8J0QYS3
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8364:dnase1l3
gene id: 8364:dnase1l3
uniprot id: Q6P7K9
names: Similarity
messages: Belongs to the DNase I family.

8364:cnrip1
gene id: 8364:cnrip1
uniprot id: B1WAU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

8364:rhagl
gene id: 8364:rhagl
uniprot id: Q3BBY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

8364:LOC100495391
gene id: 8364:LOC100495391
uniprot id: A0A8J0QYB4
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8364:LOC100495868
gene id: 8364:LOC100495868
uniprot id: A0A8J1IQ19
names: Similarity
messages: Belongs to the MHC class I family.

8364:suox
gene id: 8364:suox
uniprot id: B1WAY0
names: Function
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.

8364:LOC100487834
gene id: 8364:LOC100487834
uniprot id: A0A6I8QS17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:egfl8
gene id: 8364:egfl8
uniprot id: A0A803KKL3
uniprot id: Q0VFR0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:shroom1
gene id: 8364:shroom1
uniprot id: F7B3H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

8364:slx4ip
gene id: 8364:slx4ip
uniprot id: A4IGL8
names: Similarity
messages: Belongs to the SLX4IP family.

8364:brinp2
gene id: 8364:brinp2
uniprot id: A0A6I8T258
names: Similarity
messages: Belongs to the BRINP family.

8364:epha7
gene id: 8364:epha7
uniprot id: A0A6I8R3N5
uniprot id: A0A6I8RMX8
uniprot id: A0A6I8RQW1
uniprot id: A0A8J0QQ95
uniprot id: A0A8J0SES3
uniprot id: A0A8J0SN77
uniprot id: A0A8J0SPG7
uniprot id: A0A8J1JJT7
uniprot id: A0A8J1JJU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cacybp
gene id: 8364:cacybp
uniprot id: Q5U4Q1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

8364:tnnt1
gene id: 8364:tnnt1
uniprot id: A0A803JAG5
uniprot id: A0A803JLC4
uniprot id: A0A803JXX2
uniprot id: A0A803K6L4
uniprot id: A0A803KA09
uniprot id: A0A803KF14
uniprot id: A0A8J0QUN8
uniprot id: A0A8J0STB9
uniprot id: A0A8J0SU84
uniprot id: A0A8J1JW63
uniprot id: A0A8J1JW65
uniprot id: A0A8J1JW68
uniprot id: A0A8J1JW70
uniprot id: A0A8J1JW71
uniprot id: A0A8J1JW73
uniprot id: A0A8J1JYN8
uniprot id: A0A8J1JYP2
uniprot id: A0A8J1K084
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

8364:ptch2
gene id: 8364:ptch2
uniprot id: F6ZXC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

8364:LOC100495788
gene id: 8364:LOC100495788
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116412329
gene id: 8364:LOC116412329
uniprot id: A0A8J1JWN3
uniprot id: A0A8J1K0R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Cytoplasm

8364:ppp1r2
gene id: 8364:ppp1r2
uniprot id: B0JYX2
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

8364:lsm1
gene id: 8364:lsm1
uniprot id: Q5PPQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Probably involved with other LSm subunits in the general process of degradation of mRNAs.

8364:ppm1f
gene id: 8364:ppm1f
uniprot id: F6X7Z2
names: Similarity
messages: Belongs to the PP2C family.

8364:nudt6
gene id: 8364:nudt6
uniprot id: A0A8J0SDT6
uniprot id: A0A8J0T5A0
uniprot id: F6WT30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

8364:ak1
gene id: 8364:ak1
uniprot id: A0A6I8QVF9
uniprot id: A0A8J1IL77
uniprot id: Q6DFN0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

8364:gpr37
gene id: 8364:gpr37
uniprot id: A0A7D9NM81
uniprot id: F6TCY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Cell membrane
messages: Membrane
messages: Secreted

8364:cryab
gene id: 8364:cryab
uniprot id: A0A7D9N0F3
uniprot id: A0A8J1JZR0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8364:spata1
gene id: 8364:spata1
uniprot id: F7E3D2
names: Function
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

8364:edc4
gene id: 8364:edc4
uniprot id: A0A6I8QQP3
uniprot id: A0A8J0R0B1
uniprot id: A0A8J0R2R6
uniprot id: F6UYC3
uniprot id: F6ZUK1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EDC4 family.
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: P-body
messages: The SWIRM domain may act as an anchor site for a histone tail.

8364:foxg1
gene id: 8364:foxg1
uniprot id: B0JZE3
names: Subcellular Location Annotation
messages: Nucleus

8364:ncaph2
gene id: 8364:ncaph2
uniprot id: A0A8J1J7L5
uniprot id: Q28GV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
messages: Component of the condensin-2 complex, which contains the smc2 and smc4 heterodimer, and three non SMC subunits, ncapg2, ncaph2 and ncapd3 that probably regulate the complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture.

8364:LOC101731846
gene id: 8364:LOC101731846
uniprot id: A0A8J0T2E4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hacd1
gene id: 8364:hacd1
uniprot id: A0A803K0M2
uniprot id: F6WWY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC116408399
gene id: 8364:LOC116408399
uniprot id: A0A8J1IZK9
names: Subcellular Location Annotation
messages: Membrane

8364:slc35b1
gene id: 8364:slc35b1
uniprot id: B7ZTN3
uniprot id: Q8AXS6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable sugar transporter.
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

8364:LOC116407592
gene id: 8364:LOC116407592
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:unc45a
gene id: 8364:unc45a
uniprot id: Q640S4
names: Subcellular Location Annotation
messages: perinuclear region

8364:ddx39b
gene id: 8364:ddx39b
uniprot id: Q6P8E8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:masp1
gene id: 8364:masp1
uniprot id: A0A8J1JKX0
uniprot id: A4IH11
uniprot id: F6PUL7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:LOC100486784
gene id: 8364:LOC100486784
uniprot id: A0A803KE74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:plcd1
gene id: 8364:plcd1
uniprot id: A0A6I8Q9Q8
uniprot id: A0A6I8T151
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

8364:LOC100489992
gene id: 8364:LOC100489992
uniprot id: F7CBE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:mfsd14bl
gene id: 8364:mfsd14bl
uniprot id: B4F6S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8364:LOC100495918
gene id: 8364:LOC100495918
uniprot id: F6PZA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

8364:opn1sw
gene id: 8364:opn1sw
uniprot id: F6RHJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8364:itgae
gene id: 8364:itgae
uniprot id: A0A8J1J3U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:tll2l
gene id: 8364:tll2l
uniprot id: Q28IN5
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101734993
gene id: 8364:LOC101734993
uniprot id: A0A8J1JPR4
names: Similarity
messages: Belongs to the apolipoprotein L family.

8364:mrpl42
gene id: 8364:mrpl42
uniprot id: Q0V9E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

8364:pcsk4
gene id: 8364:pcsk4
uniprot id: A0A6I8Q8M5
uniprot id: A0A8J1JHX4
uniprot id: Q0V9N1
names: Similarity
messages: Belongs to the peptidase S8 family.

8364:cox7a2l
gene id: 8364:cox7a2l
uniprot id: Q4V9Y2
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

8364:h2aj
gene id: 8364:h2aj
uniprot id: Q6DK82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:amotl2
gene id: 8364:amotl2
uniprot id: A0A8J1JKT0
names: Similarity
messages: Belongs to the angiomotin family.

8364:LOC116408039
gene id: 8364:LOC116408039
uniprot id: A0A8J1IYF1
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:copb2
gene id: 8364:copb2
uniprot id: Q4VA86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
messages: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.

8364:crygdl.33
gene id: 8364:crygdl.33
uniprot id: A0A8J0R049
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:kif11
gene id: 8364:kif11
uniprot id: B2GU58
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
messages: Cytoplasm
messages: Heterotetramer of two heavy and two light chains. Interacts with aurka (By similarity).
messages: Phosphorylated on a serine residue by aurka.
messages: Phosphorylation of Thr-937 during mitosis controls the association of this protein with the spindle apparatus.
messages: Plus end-directed motor protein required for establishing a bipolar spindle. Associates with both interphase and mitotic spindle microtubules. May be involved in nuclear divisions taking place during the development of unfertilized eggs. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface.
messages: spindle pole

8364:cldn17.1
gene id: 8364:cldn17.1
uniprot id: A0A803K687
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:ost4
gene id: 8364:ost4
uniprot id: A0A8J1JIZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:coq9
gene id: 8364:coq9
uniprot id: Q5RJV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ9 family.
messages: Homodimer.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group.
messages: Mitochondrion
messages: Structurally similar to the bacterial FadR protein (fatty acid metabolism regulator protein).

8364:LOC100497894
gene id: 8364:LOC100497894
uniprot id: A0A8J0R4P4
uniprot id: F6SVR5
names: Subcellular Location Annotation
messages: Nucleus

8364:tmem39b
gene id: 8364:tmem39b
uniprot id: A0A8J0SF57
uniprot id: F6VEJ3
uniprot id: Q6DF19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

8364:grid2
gene id: 8364:grid2
uniprot id: A0A803J7I0
uniprot id: A0A8J1JMC6
uniprot id: A0A8J1JPS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:tmem91
gene id: 8364:tmem91
uniprot id: A0A8J1IT27
uniprot id: F7AMQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Belongs to the CD225/Dispanin family.
messages: Nucleus

8364:slc39a1l
gene id: 8364:slc39a1l
uniprot id: A0A803KL44
uniprot id: Q28E43
names: Subcellular Location Annotation
messages: Membrane

8364:slc45a2
gene id: 8364:slc45a2
uniprot id: Q5M7S3
names: Subcellular Location Annotation
messages: Membrane

8364:ptk7
gene id: 8364:ptk7
uniprot id: A0A803JGE7
uniprot id: A0A8J1JNG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hgd
gene id: 8364:hgd
uniprot id: A0A8J0QHB1
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

8364:nrg1
gene id: 8364:nrg1
uniprot id: A0A6I8QTH8
uniprot id: A0A6I8RI47
uniprot id: A0A8J0S6E1
uniprot id: A0A8J0SAR7
uniprot id: A0A8J0SDC8
uniprot id: A0A8J0SDD2
uniprot id: A0A8J0SDM0
uniprot id: A0A8J0T5E1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

8364:pde8b
gene id: 8364:pde8b
uniprot id: A0A7D9NKC6
uniprot id: A0A8J0QZE5
uniprot id: A0A8J0QZT4
uniprot id: A0A8J0SJH6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:sox9
gene id: 8364:sox9
uniprot id: A0A8J1IWP3
uniprot id: Q6F2E7
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in both male and female gonads from after metamorphosis through to adult stages. In the testis, expression is restricted to the supporting Sertoli-like cells. Conversely in the ovary, expression is localized to primary oocytes (at protein level). In developing limbs, expressed before chrondrocytes form (stage 52 tadpoles) and throughout the cartilaginous anlagen until stage 56, after which expression ceases in the enlarged cells of the diaphysis. At later stages, expression continues in the chondrocytes of the epiphysis and metaphysis, and weak expression is seen in most of the diaphysis.
messages: Interacts with the sumoylation factors ube2i/ubc9 and sumo1.
messages: Nucleus
messages: Sumoylated. Lys-370 is the major site of sumoylation, although sumoylation at Lys-61 also occurs. Sumoylation plays a key role in regulating formation of the neural crest and otic placode (By similarity).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development. Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1. Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes. Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis. Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes. Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells. Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation. In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells (By similarity). Unlikely to play a role in sex determination but may function during testicular and ovarian differentiation (PubMed:18692165, PubMed:18816826).

8364:leo1
gene id: 8364:leo1
uniprot id: F7EB62
names: Similarity
messages: Belongs to the LEO1 family.

8364:atp10b
gene id: 8364:atp10b
uniprot id: A0A6I8S6N2
uniprot id: F6WCS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8364:LOC116408712
gene id: 8364:LOC116408712
uniprot id: A0A8J1J6E7
names: Subcellular Location Annotation
messages: Nucleus

8364:ccdc134
gene id: 8364:ccdc134
uniprot id: Q28F39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC134 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: In extracellular secreted form, promotes proliferation and activation of T cells, suggesting a cytokine-like function. May inhibit ERK and JNK signaling activity and suppress cell migration and invasion activity. Has a critical role in the regulation of osteogenesis and bone development.
messages: In the nucleus, enhances activity of the PCAF histone acetyltransferase (HAT) complex.
messages: Nucleus
messages: Secreted

8364:LOC100490967
gene id: 8364:LOC100490967
uniprot id: A0A6I8QB71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101731162
gene id: 8364:LOC101731162
uniprot id: A0A8J0R2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:atp7b
gene id: 8364:atp7b
uniprot id: A0A6I8R0A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

8364:ppp1r12a
gene id: 8364:ppp1r12a
uniprot id: A0A8J1JCT1
uniprot id: F6ZNU5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.

8364:mtg1
gene id: 8364:mtg1
uniprot id: A9JTX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Mitochondrion inner membrane
messages: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity).

8364:ndufs5
gene id: 8364:ndufs5
uniprot id: A4QNJ5
uniprot id: F6XRW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

8364:fxyd6
gene id: 8364:fxyd6
uniprot id: A4QNE5
names: Similarity
messages: Belongs to the FXYD family.

8364:mas1l
gene id: 8364:mas1l
uniprot id: A0A803KCX8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:mrpl28
gene id: 8364:mrpl28
uniprot id: B7ZSU9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

8364:LOC116409676
gene id: 8364:LOC116409676
uniprot id: A0A803K0A3
uniprot id: A0A803KDY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

8364:h4c1
gene id: 8364:h4c1
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:LOC100490312
gene id: 8364:LOC100490312
uniprot id: A0A8J1IPU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:hoxb1
gene id: 8364:hoxb1
uniprot id: A0A803JG60
uniprot id: A0A8J0QPA7
names: Subcellular Location Annotation
messages: Nucleus

8364:fut1
gene id: 8364:fut1
uniprot id: Q6EV72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

8364:epyc
gene id: 8364:epyc
uniprot id: F7CB65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: extracellular matrix

8364:LOC100493820
gene id: 8364:LOC100493820
uniprot id: A0A8J1IS86
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:vps4b
gene id: 8364:vps4b
uniprot id: Q5U4Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8364:gnpat
gene id: 8364:gnpat
uniprot id: A0A8J0SEE1
uniprot id: Q0P4P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

8364:sf3a2
gene id: 8364:sf3a2
uniprot id: Q6GLH3
names: Similarity
messages: Belongs to the SF3A2 family.

8364:bix1.1
gene id: 8364:bix1.1
uniprot id: A0A6I8RXZ7
uniprot id: Q8AWG9
names: Subcellular Location Annotation
messages: Nucleus

8364:tnc
gene id: 8364:tnc
uniprot id: A0A6I8Q0Y8
uniprot id: A0A6I8R917
uniprot id: A0A6I8R996
uniprot id: F7DIV8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:kiaa1191
gene id: 8364:kiaa1191
uniprot id: A0A8J0SGJ3
uniprot id: B1H2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P33MONOX family.
messages: Cytoplasm

8364:pou3f4
gene id: 8364:pou3f4
uniprot id: A1L0Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus
messages: Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation (By similarity).

8364:awat1
gene id: 8364:awat1
uniprot id: A0A8J0SXY0
uniprot id: A8E5W0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sass6
gene id: 8364:sass6
uniprot id: F7CIV0
uniprot id: F7CJ32
uniprot id: Q28C08
names: Subcellular Location Annotation
messages: centrosome

8364:prtg
gene id: 8364:prtg
uniprot id: F7E412
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

8364:ntrk3
gene id: 8364:ntrk3
uniprot id: A0A8J0QXE9
uniprot id: A0A8J1JB52
uniprot id: A0A8J1JEM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:foxo6
gene id: 8364:foxo6
uniprot id: F6QQK3
names: Subcellular Location Annotation
messages: Nucleus

8364:cyp51a1
gene id: 8364:cyp51a1
uniprot id: Q28CJ0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:ccdc88a
gene id: 8364:ccdc88a
uniprot id: F6RYN0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:pde3a
gene id: 8364:pde3a
uniprot id: A0A8J1J7W0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:acadsb
gene id: 8364:acadsb
uniprot id: Q28FB8
uniprot id: Q6DJ59
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8364:tfcp2l1
gene id: 8364:tfcp2l1
uniprot id: A0A8J1IXB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

8364:gpr6
gene id: 8364:gpr6
uniprot id: A0A6I8PY67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cacna1s
gene id: 8364:cacna1s
uniprot id: A0A6I8QW04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

8364:ripor2
gene id: 8364:ripor2
uniprot id: A0A6I8RVC0
uniprot id: A0A6I8S6U7
uniprot id: B3DLI7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: stereocilium membrane

8364:cryba1.2
gene id: 8364:cryba1.2
uniprot id: A0A8J0QRE1
uniprot id: F7EJV5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC101732687
gene id: 8364:LOC101732687
uniprot id: A0A8J0R271
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105945564
gene id: 8364:LOC105945564
uniprot id: A0A8J0T256
names: Subcellular Location Annotation
messages: Membrane

8364:osbpl8
gene id: 8364:osbpl8
uniprot id: A0A5S6LM29
uniprot id: A0A6I8Q938
uniprot id: A0A6I8SL12
uniprot id: A0A8J0S912
uniprot id: A0A8J0S914
uniprot id: A0A8J0SET9
uniprot id: A0A8J0SEU3
uniprot id: A0A8J0SGJ8
uniprot id: A0A8J1J903
uniprot id: B1H2N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Cytoplasm
messages: Nucleus

8364:chm
gene id: 8364:chm
uniprot id: A0A6I8R688
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

8364:vgll1
gene id: 8364:vgll1
uniprot id: F6PVE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

8364:chchd5
gene id: 8364:chchd5
uniprot id: F6T2M6
names: Similarity
messages: Belongs to the beta-catenin family.

8364:tff3.3
gene id: 8364:tff3.3
uniprot id: A0A8J0QU96
names: Subcellular Location Annotation
messages: Secreted

8364:arhgap42
gene id: 8364:arhgap42
uniprot id: F7ED67
names: Similarity
messages: Belongs to the copine family.

8364:LOC100495212
gene id: 8364:LOC100495212
uniprot id: A0A803J2Y6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:acoxl
gene id: 8364:acoxl
uniprot id: A0A8J0QSS7
uniprot id: F7EFS0
names: Similarity
messages: Belongs to the acyl-CoA oxidase family.

8364:kcnb2
gene id: 8364:kcnb2
uniprot id: F6SBN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon

8364:nr2f5
gene id: 8364:nr2f5
uniprot id: A0A8J0R6A9
uniprot id: F7BFY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:nr4a3
gene id: 8364:nr4a3
uniprot id: A0A8J1JTY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:rps28p9
gene id: 8364:rps28p9
uniprot id: Q0VGV3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

8364:megf6
gene id: 8364:megf6
uniprot id: A0A6I8Q838
uniprot id: F6UCL2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:hs3st2
gene id: 8364:hs3st2
uniprot id: A0A5S6N1G7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:slc6a4l
gene id: 8364:slc6a4l
uniprot id: F7B9G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:kif21a
gene id: 8364:kif21a
uniprot id: A0A6I8S3D4
uniprot id: A0A6I8SF65
uniprot id: A0A8J0QG12
uniprot id: A0A8J0SF25
uniprot id: A0A8J0SGS8
uniprot id: A0A8J0SI00
uniprot id: F6T7R7
uniprot id: L7N2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

8364:rundc3a
gene id: 8364:rundc3a
uniprot id: Q0V9V7
names: Similarity
messages: Belongs to the RUNDC3 family.

8364:mmp8
gene id: 8364:mmp8
uniprot id: A0A6I8PQT5
uniprot id: A0A6I8RKW0
names: Similarity
messages: Belongs to the peptidase M10A family.

8364:mafb
gene id: 8364:mafb
uniprot id: Q504L8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator or repressor. Implicated in the regulation of cell-type specific gene expression and play a role in inductive events during lens development (By similarity).
messages: Belongs to the bZIP family. Maf subfamily.
messages: Expressed in the somites at stage 19 onwards. Expressed in the developing hindbrain between neural plate at stage 32. Expressed in the ventral blood islands from stage 22 until stage 28. Expressed in the condensing pronephros at stage 24. Expressed in the pronephric tubules at stage 33. Expressed in the presumptive lens-forming ectoderm (PLE) at stage 22 and during lens formation. Expressed in the invaginating placode at stage 28. Expressed in lens epithelia at stage 33. Expressed in the rhombencephalon at least until stage 40. Expressed in the olfactory bulb and the thalamus at stage 43. Expressed in the neural crest cells.
messages: Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer (By similarity).
messages: Nucleus

8364:yme1l1
gene id: 8364:yme1l1
uniprot id: F7DF24
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

8364:gask1b
gene id: 8364:gask1b
uniprot id: A0A8J0QK67
names: Similarity
messages: Belongs to the GASK family.

8364:LOC108646266
gene id: 8364:LOC108646266
uniprot id: A0A8J0T2Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:msh6
gene id: 8364:msh6
uniprot id: F7EDR7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

8364:dop1a
gene id: 8364:dop1a
uniprot id: A0A8J0QFX9
uniprot id: A0A8J1JI82
uniprot id: F7E089
uniprot id: F7E097
names: Similarity
messages: Belongs to the dopey family.

8364:tph2
gene id: 8364:tph2
uniprot id: A0A8J0QWL5
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

8364:tbx22
gene id: 8364:tbx22
uniprot id: F6X1X4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:car1 predicted
gene id: 8364:car1_predicted
uniprot id: Q0VFA2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:irf7
gene id: 8364:irf7
uniprot id: A0A6I8SJ88
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:LOC100491668
gene id: 8364:LOC100491668
uniprot id: A0A8J0QQ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

8364:bsk146
gene id: 8364:bsk146
uniprot id: F6VK53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

8364:mtfr1
gene id: 8364:mtfr1
uniprot id: A0A803K3M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

8364:LOC116407963
gene id: 8364:LOC116407963
uniprot id: A0A8J1J0R1
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC105946967
gene id: 8364:LOC105946967
uniprot id: A0A8J1J8H1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:efemp2
gene id: 8364:efemp2
uniprot id: F7CZS3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tjap1
gene id: 8364:tjap1
uniprot id: A0A803J906
uniprot id: A0A8J1JL13
names: Subcellular Location Annotation
messages: Membrane

8364:cldn8.4
gene id: 8364:cldn8.4
uniprot id: B1H1G6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:chchd7
gene id: 8364:chchd7
uniprot id: Q28GG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHCHD7 family.
messages: Mitochondrion intermembrane space

8364:epo
gene id: 8364:epo
uniprot id: A0A8J0S6A8
uniprot id: G0T3F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

8364:vta1
gene id: 8364:vta1
uniprot id: Q66IK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

8364:hbp1
gene id: 8364:hbp1
uniprot id: A0A8J0S9C4
uniprot id: A0A8J0SFB9
uniprot id: F7EI74
uniprot id: F7EI78
uniprot id: Q642N2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

8364:pou6f2
gene id: 8364:pou6f2
uniprot id: A0A8J0SH70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8364:tgfb1
gene id: 8364:tgfb1
uniprot id: F6U272
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

8364:LOC108646245
gene id: 8364:LOC108646245
uniprot id: A0A8J0T1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:stx11
gene id: 8364:stx11
uniprot id: F6VUS3
names: Similarity
messages: Belongs to the syntaxin family.

8364:tradd
gene id: 8364:tradd
uniprot id: A0A6I8PY50
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

8364:LOC108647387
gene id: 8364:LOC108647387
uniprot id: A0A8J0T084
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:gpsm2
gene id: 8364:gpsm2
uniprot id: A0A6I8RRH9
uniprot id: A0A8J0R3G3
uniprot id: A0A8J0SMY0
uniprot id: A0A8J0SN20
names: Similarity
messages: Belongs to the GPSM family.

8364:pax9
gene id: 8364:pax9
uniprot id: A0A6I8R708
names: Subcellular Location Annotation
messages: Nucleus

8364:amigo2
gene id: 8364:amigo2
uniprot id: A0A6I8Q2X2
uniprot id: A0A803JIB2
uniprot id: F6PZD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

8364:grhl1
gene id: 8364:grhl1
uniprot id: A0A6I8SEZ4
uniprot id: A0A8J0QUI8
uniprot id: A0A8J0QVG7
uniprot id: A0A8J0R1J0
uniprot id: A0A8J0R3I1
uniprot id: A0A8J0R450
uniprot id: A0A8J0R4N6
uniprot id: A0A8J0SPB7
names: Subcellular Location Annotation
messages: Nucleus

8364:tmem189
gene id: 8364:tmem189
uniprot id: A0A803JR74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

8364:kcnj16
gene id: 8364:kcnj16
uniprot id: A0A803K6V5
uniprot id: B1WAZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:flot2
gene id: 8364:flot2
uniprot id: A0A6I8SF28
uniprot id: A0A8J0SFE1
uniprot id: Q5XHK4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane

8364:prpsap2
gene id: 8364:prpsap2
uniprot id: Q28DH0
names: Function
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

8364:cand2
gene id: 8364:cand2
uniprot id: A0A6I8SW24
uniprot id: A0A8J0SCQ1
names: Similarity
messages: Belongs to the CAND family.

8364:pfdn6
gene id: 8364:pfdn6
uniprot id: Q28CE5
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

8364:gpx2
gene id: 8364:gpx2
uniprot id: A0A8J0QGI1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

8364:fis1
gene id: 8364:fis1
uniprot id: B2RZ06
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

8364:clcn3
gene id: 8364:clcn3
uniprot id: A0A6I8Q6Z5
uniprot id: A0A6I8RL53
uniprot id: A0A8J0S868
uniprot id: A0A8J0SF99
uniprot id: A0A8J0SGD2
uniprot id: B4F6X6
uniprot id: F6ZKG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

8364:ext2
gene id: 8364:ext2
uniprot id: B2GUE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

8364:LOC101731023
gene id: 8364:LOC101731023
uniprot id: A0A8J0R3H3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC101734834
gene id: 8364:LOC101734834
uniprot id: A0A8J1J313
names: Subcellular Location Annotation
messages: Membrane

8364:rpl28
gene id: 8364:rpl28
uniprot id: A0A803KGS5
uniprot id: F6XCL8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

8364:parp8
gene id: 8364:parp8
uniprot id: A0A803KDH5
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:slc13a2
gene id: 8364:slc13a2
uniprot id: F7CVA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8364:hhat
gene id: 8364:hhat
uniprot id: A0A8J1JKQ8
uniprot id: F6YU00
names: Subcellular Location Annotation
messages: Membrane

8364:tns3
gene id: 8364:tns3
uniprot id: A0A8J1JQZ2
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

8364:rabggta
gene id: 8364:rabggta
uniprot id: Q6DIR3
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

8364:t2r20
gene id: 8364:t2r20
uniprot id: A0A8J1ISX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:lsm8
gene id: 8364:lsm8
uniprot id: F6VGY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

8364:casp2
gene id: 8364:casp2
uniprot id: F6RDY9
names: Similarity
messages: Belongs to the peptidase C14A family.

8364:dock9
gene id: 8364:dock9
uniprot id: A0A6I8PZ19
uniprot id: A0A6I8Q4S9
uniprot id: A0A6I8QTK5
uniprot id: A0A6I8STS0
uniprot id: A0A8J0SEN4
uniprot id: A0A8J0SY73
uniprot id: A0A8J0T1D5
uniprot id: A0A8J1J4V6
uniprot id: A0A8J1J4W1
uniprot id: A0A8J1J4W3
uniprot id: A0A8J1J4W6
uniprot id: A0A8J1J4X0
uniprot id: A0A8J1J4X2
uniprot id: A0A8J1J7A8
uniprot id: A0A8J1J7B3
uniprot id: A0A8J1J8B0
uniprot id: A0A8J1J8B5
names: Similarity
messages: Belongs to the DOCK family.

8364:LOC100488540
gene id: 8364:LOC100488540
uniprot id: A0A803K5W4
uniprot id: F7BJ13
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

8364:slc31a1
gene id: 8364:slc31a1
uniprot id: Q6NVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

8364:uggt2
gene id: 8364:uggt2
uniprot id: F6ZBQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

8364:slc2a10
gene id: 8364:slc2a10
uniprot id: Q0P4G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Endomembrane system
messages: Facilitative glucose transporter required for the development of the cardiovascular system.
messages: perinuclear region

8364:eif3g
gene id: 8364:eif3g
uniprot id: Q28CY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

8364:cnga4
gene id: 8364:cnga4
uniprot id: F6VIY1
names: Subcellular Location Annotation
messages: Membrane

8364:hdac10
gene id: 8364:hdac10
uniprot id: A0A6I8R3W1
uniprot id: A0A8J0QLK1
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC116412270
gene id: 8364:LOC116412270
uniprot id: A0A8J1JZU6
names: Similarity
messages: Belongs to the Izumo family.

8364:rnpc3
gene id: 8364:rnpc3
uniprot id: Q07G30
names: Subcellular Location Annotation
messages: Nucleus

8364:foxf1
gene id: 8364:foxf1
uniprot id: Q28BS5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable transcription factor. Required for smooth muscle (visceral mesoderm) differentiation during gut development. Also required for normal proliferation of the lateral plate mesoderm. Acts as a downstream mediator of bmp4-signaling (By similarity).

8364:lamp3
gene id: 8364:lamp3
uniprot id: A0A6I8RJ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

8364:mrps26
gene id: 8364:mrps26
uniprot id: A4IHL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

8364:LOC108644698
gene id: 8364:LOC108644698
uniprot id: A0A8J1JLA6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cdx1
gene id: 8364:cdx1
uniprot id: Q90X89
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Expressed around the blastopore through gastrula stages. Expressed in the neural tube (posterior dorsal neuroectoderm and the posterior ventral ectoderm) at late neurula stage 20. Expressed in the posterior tip of the neural tube and the posterior wall of the neuroenteric canal at tail bud stage 30. Expressed in the developing gut at stage 40.
messages: Nucleus
messages: Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.

8364:suclg2
gene id: 8364:suclg2
uniprot id: A0A1B8YAJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

8364:siva1
gene id: 8364:siva1
uniprot id: F6Z3L8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus

8364:ntf3
gene id: 8364:ntf3
uniprot id: A0A6I8QMK6
uniprot id: A0A8J0SFK4
uniprot id: F7EB21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted
messages: Seems to promote the survival of visceral and proprioceptive sensory neurons.

8364:itga4
gene id: 8364:itga4
uniprot id: F6Q166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:rpn1
gene id: 8364:rpn1
uniprot id: Q6P1S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

8364:rrn3
gene id: 8364:rrn3
uniprot id: A0A6I8QER1
uniprot id: F6UJX4
names: Similarity
messages: Belongs to the RRN3 family.
messages: Belongs to the methylmalonyl-CoA epimerase family.

8364:LOC116408581
gene id: 8364:LOC116408581
uniprot id: A0A8J1J2G0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:kif2a
gene id: 8364:kif2a
uniprot id: A0A6I8PYR7
uniprot id: A0A8J0QPH5
uniprot id: A0A8J0QUN6
uniprot id: A0A8J0QYX9
uniprot id: F6Q890
uniprot id: F7DZW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Nucleus

8364:p2ry11
gene id: 8364:p2ry11
uniprot id: F6QA86
uniprot id: Q6GLI0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:nupl2
gene id: 8364:nupl2
uniprot id: Q5FVW4
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus membrane
messages: Probable component of the nuclear pore complex (NPC).
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
messages: The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.
messages: nuclear pore complex

8364:LOC116409611
gene id: 8364:LOC116409611
uniprot id: A0A8J1JAZ6
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100491664
gene id: 8364:LOC100491664
uniprot id: A0A8J1IPS5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:capn15
gene id: 8364:capn15
uniprot id: A0A6I8RE76
uniprot id: A0A8J1IRW8
uniprot id: A8WGH7
uniprot id: F6TNB8
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:LOC100493210
gene id: 8364:LOC100493210
uniprot id: A0A8J0QUK7
names: Similarity
messages: Belongs to the cyclin family.

8364:treh
gene id: 8364:treh
uniprot id: A0A6I8S8S0
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

8364:t2r49
gene id: 8364:t2r49
uniprot id: Q2AB38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:drgx
gene id: 8364:drgx
uniprot id: A0A6I8PWK2
uniprot id: A0A803J971
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100486691
gene id: 8364:LOC100486691
uniprot id: A0A8J1JR06
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:rpl22
gene id: 8364:rpl22
uniprot id: B0JZZ5
uniprot id: Q28IL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8364:rbfox1
gene id: 8364:rbfox1
uniprot id: A0A6I8QB91
uniprot id: A0A803JQ31
uniprot id: A0A8J0QXA1
uniprot id: A0A8J0SYE7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

8364:eml2
gene id: 8364:eml2
uniprot id: A0A6I8QNQ0
uniprot id: A0A6I8SNH7
uniprot id: A0A8J0QMD2
uniprot id: A0A8J0R630
uniprot id: A0A8J0SU19
uniprot id: A0A8J1IRK8
uniprot id: A0A8J1IRM5
names: Similarity
messages: Belongs to the WD repeat EMAP family.

8364:LOC101731802
gene id: 8364:LOC101731802
uniprot id: F7CCX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:epc2
gene id: 8364:epc2
uniprot id: Q6DJR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: May play a role in transcription or DNA repair.
messages: Nucleus

8364:dll4
gene id: 8364:dll4
uniprot id: A0A6I8QZV4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8364:LOC100489122
gene id: 8364:LOC100489122
uniprot id: F7D3H1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:snrpa1
gene id: 8364:snrpa1
uniprot id: A0A6I8SPP8
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

8364:LOC116407547
gene id: 8364:LOC116407547
uniprot id: A0A8J1ITB9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:hnf1a
gene id: 8364:hnf1a
uniprot id: B1WB01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

8364:snapin
gene id: 8364:snapin
uniprot id: B0BML4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

8364:LOC116407796
gene id: 8364:LOC116407796
uniprot id: A0A8J1IY42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:sgpl1
gene id: 8364:sgpl1
uniprot id: A0A6I8QIC5
names: Similarity
messages: Belongs to the group II decarboxylase family.

8364:ogdh
gene id: 8364:ogdh
uniprot id: A0A6I8SYF4
uniprot id: F6Z470
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

8364:gde1
gene id: 8364:gde1
uniprot id: F6W9P3
uniprot id: Q28HT8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8364:adamts10
gene id: 8364:adamts10
uniprot id: A0A6I8QWM6
uniprot id: A0A8J1JSI2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:wdr82
gene id: 8364:wdr82
uniprot id: Q6GL39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SWD2 family.
messages: Chromosome
messages: Component of the SET1 complex.
messages: Nucleus
messages: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

8364:otogl
gene id: 8364:otogl
uniprot id: A0A8J1JDM8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:rbbp5
gene id: 8364:rbbp5
uniprot id: A0A803KLE8
uniprot id: F6QZB2
names: Subcellular Location Annotation
messages: Nucleus

8364:appl2
gene id: 8364:appl2
uniprot id: A9JTS8
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

8364:get4
gene id: 8364:get4
uniprot id: A4QNE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of a cytosolic protein quality control complex, the bag6/bat3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The bag6/bat3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Similarly, the bag6/bat3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The bag6/bat3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
messages: Belongs to the GET4 family.
messages: Component of the bag6/bat3 complex.
messages: cytosol

8364:LOC108648797
gene id: 8364:LOC108648797
uniprot id: A0A8J0T626
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:exoc3l4
gene id: 8364:exoc3l4
uniprot id: A0A803KBX6
names: Similarity
messages: Belongs to the SEC6 family.

8364:LOC100490015
gene id: 8364:LOC100490015
uniprot id: A0A8J0QMD1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:fam131c
gene id: 8364:fam131c
uniprot id: A0A803JLN7
names: Similarity
messages: Belongs to the FAM131 family.

8364:aldh4a1
gene id: 8364:aldh4a1
uniprot id: A4QNJ0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:oat
gene id: 8364:oat
uniprot id: Q28FA4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

8364:nr1i2
gene id: 8364:nr1i2
uniprot id: A0A8J0Q7S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8364:rad23b
gene id: 8364:rad23b
uniprot id: A0A8J0SPP0
uniprot id: F7A2H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

8364:rad18
gene id: 8364:rad18
uniprot id: A0A6I8S196
uniprot id: A0A803K3L3
uniprot id: A0A803K4B5
uniprot id: A0A8J1JGM4
uniprot id: F6UP78
uniprot id: F6YP99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Nucleus

8364:rpusd2
gene id: 8364:rpusd2
uniprot id: A0A8J0QXB5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

8364:LOC100489507
gene id: 8364:LOC100489507
uniprot id: A0A7D9NKH0
uniprot id: F6U2L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ10 family.
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Interacts with coenzyme Q.
messages: Membrane
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

8364:ormdl1
gene id: 8364:ormdl1
uniprot id: A4IID7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

8364:rsl24d1
gene id: 8364:rsl24d1
uniprot id: F6WZU3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

8364:rps18
gene id: 8364:rps18
uniprot id: A9JSA5
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

8364:hrh3
gene id: 8364:hrh3
uniprot id: A0A803JTQ8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:eif2b2
gene id: 8364:eif2b2
uniprot id: A9ULB2
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

8364:bora
gene id: 8364:bora
uniprot id: A0A6I8PVN9
uniprot id: A0A8J1J517
names: Similarity
messages: Belongs to the BORA family.

8364:tbx2
gene id: 8364:tbx2
uniprot id: Q3SA48
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a monomer.
messages: Expressed ventrally in early gastrulae (stage 10.5) and is expressed most strongly in the outer layer of ectodermal cells. At the late gastrula stage (stage 12), expression appears to be up-regulated consistently in a small group of cells clustered around the ventral edge of the closing blastopore. At the early neurula stage (stage 13), four regions of ectodermal expression are clearly detected. At stage 19 (late neurula), expression persists in the cement gland, the ventral epidermis, the proctodeal region, the lens placodes, and in a broad placodal area caudal to the eye anlagen. In addition, expression also detected in the dorsal root ganglia of the future spinal cord. At stage 21/22, expression seen in a wishbone-shaped group of cells situated dorsal and caudal to each developing optic vesicle corresponding to the cranial (profundal and trigeminal) ganglia. Expression persists in these cells through tail bud and into early tadpole stages. From stage 21/22 onward, the bilateral expression in the ectodermal placodes becomes restricted primarily to the otic placode and the developing otic vesicles. At stage 24, also observed in the precursors of the hypaxial muscles and the pronephric duct in the trunk, in the developing branchial arches and in the primordium of the heart. In stage 29 embryos, expression detected in the frontonasal process and continues to be expressed in the same regions of the embryo at stage 33, although its expression becomes clearly regionalized in the looping heart. A higher level of expression seen in the ventricle as compared with the atrium.
messages: Nucleus
messages: Transcription factor which acts as a transcriptional repressor (By similarity). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity).

8364:bc014685
gene id: 8364:bc014685
uniprot id: Q28IE8
names: Subcellular Location Annotation
messages: Membrane

8364:galnt13
gene id: 8364:galnt13
uniprot id: A0A7D9NLT9
uniprot id: A0A803JGW9
uniprot id: Q0P4W5
uniprot id: Q28D20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:usp2
gene id: 8364:usp2
uniprot id: A0A6I8SRE1
uniprot id: B4F6P0
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:cyyr1
gene id: 8364:cyyr1
uniprot id: A0A8J0PHQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYYR1 family.
messages: Membrane

8364:papss2
gene id: 8364:papss2
uniprot id: A0A6I8SCJ2
uniprot id: A0A6I8T2A5
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

8364:LOC116409549
gene id: 8364:LOC116409549
uniprot id: A0A8J1JBR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:b4galnt1
gene id: 8364:b4galnt1
uniprot id: A0A803KCL4
uniprot id: A0A803KJG5
uniprot id: F7CXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC100486623
gene id: 8364:LOC100486623
uniprot id: A0A8J1JVQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101730806
gene id: 8364:LOC101730806
uniprot id: A0A1B8Y806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:anpep
gene id: 8364:anpep
uniprot id: A0A6I8Q201
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8364:LOC100489659
gene id: 8364:LOC100489659
uniprot id: A0A8J1IQP8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:LOC108644815
gene id: 8364:LOC108644815
uniprot id: A0A1B8Y6Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:rpl14
gene id: 8364:rpl14
uniprot id: Q28CV5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

8364:eloa
gene id: 8364:eloa
uniprot id: F6UT31
names: Subcellular Location Annotation
messages: Nucleus

8364:erfl
gene id: 8364:erfl
uniprot id: A0A8J0R577
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:atp6v0e2
gene id: 8364:atp6v0e2
uniprot id: A4IH67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8364:trpc3
gene id: 8364:trpc3
uniprot id: A0A803JVP3
names: Subcellular Location Annotation
messages: Membrane

8364:pkp1
gene id: 8364:pkp1
uniprot id: A0A8J0SDD9
names: Similarity
messages: Belongs to the beta-catenin family.

8364:smu1
gene id: 8364:smu1
uniprot id: Q6P4J8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SMU1 family.
messages: Component of the spliceosome B complex. Interacts with ik.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Required for normal accumulation of ik (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The WD repeats assemble into a seven-bladed WD propeller.

8364:LOC548390
gene id: 8364:LOC548390
uniprot id: F7CT86
names: Similarity
messages: Belongs to the IUNH family.

8364:fgd6
gene id: 8364:fgd6
uniprot id: A0A7D9NLI2
uniprot id: A0A803JQC5
names: Subcellular Location Annotation
messages: cytoskeleton

8364:LOC100494782
gene id: 8364:LOC100494782
uniprot id: A0A8J1JEJ7
uniprot id: F7CBB0
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:tas2r7
gene id: 8364:tas2r7
uniprot id: Q2AB80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:grin3a
gene id: 8364:grin3a
uniprot id: F7E003
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:mos
gene id: 8364:mos
uniprot id: A0A8J1JPQ9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC116406824
gene id: 8364:LOC116406824
uniprot id: A0A8J1IPT7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:stx1a
gene id: 8364:stx1a
uniprot id: Q0VFR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

8364:mzt1
gene id: 8364:mzt1
uniprot id: A0A8J0PHN5
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

8364:brs3
gene id: 8364:brs3
uniprot id: F6PV41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:stat3.2
gene id: 8364:stat3.2
uniprot id: A0A6I8RHV0
uniprot id: A0A8J1J0L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8364:LOC100496693
gene id: 8364:LOC100496693
uniprot id: A0A8J0STN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:astl3b.4
gene id: 8364:astl3b.4
uniprot id: A0A8J1IMK2
uniprot id: A0A8J1IMK3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:pitx2
gene id: 8364:pitx2
uniprot id: B0JZ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

8364:crygdl.2
gene id: 8364:crygdl.2
uniprot id: A0A8J0QP85
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:gal3st2
gene id: 8364:gal3st2
uniprot id: F6T055
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

8364:aldh3b1
gene id: 8364:aldh3b1
uniprot id: F6TDB4
uniprot id: Q28FB2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:LOC100491713
gene id: 8364:LOC100491713
uniprot id: A0A8J0QI85
names: Similarity
messages: Belongs to the TGF-beta family.

8364:LOC101734387
gene id: 8364:LOC101734387
uniprot id: A0A8J1IMD2
names: Similarity
messages: Belongs to the MHC class I family.

8364:gfod2
gene id: 8364:gfod2
uniprot id: Q5BKK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Gfo/Idh/MocA family.
messages: Promotes matrix assembly.
messages: extracellular matrix

8364:nrxn3
gene id: 8364:nrxn3
uniprot id: A0A8J0T5E6
uniprot id: A0A8J1IME2
uniprot id: A0A8J1IME4
uniprot id: A0A8J1IME5
uniprot id: A0A8J1IME7
uniprot id: A0A8J1IME8
uniprot id: A0A8J1IME9
uniprot id: A0A8J1IMF1
uniprot id: A0A8J1IMF2
uniprot id: A0A8J1IMF4
uniprot id: A0A8J1IPM5
uniprot id: A0A8J1IPN0
uniprot id: A0A8J1IQB5
uniprot id: A0A8J1IQC0
uniprot id: A0A8J1IQC5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:fgf23.2
gene id: 8364:fgf23.2
uniprot id: A0A6I8PM12
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:p2rx7
gene id: 8364:p2rx7
uniprot id: A0A8J0T134
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8364:LOC100494768
gene id: 8364:LOC100494768
uniprot id: A0A8J1J3Q4
uniprot id: A0A8J1J756
uniprot id: F7ADE4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100145174
gene id: 8364:LOC100145174
uniprot id: F7BI54
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:LOC116409644
gene id: 8364:LOC116409644
uniprot id: A0A8J1J8N8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:ahsa1
gene id: 8364:ahsa1
uniprot id: F6WM96
names: Similarity
messages: Belongs to the AHA1 family.

8364:serpina3
gene id: 8364:serpina3
uniprot id: Q5M8K2
names: Similarity
messages: Belongs to the serpin family.

8364:LOC100496293
gene id: 8364:LOC100496293
uniprot id: A0A6I8QUK5
uniprot id: A0A6I8SM89
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100495571
gene id: 8364:LOC100495571
uniprot id: A0A6I8S1C7
uniprot id: A0A8J0SHW4
uniprot id: F7B5H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: LSm subunits form a heteromer with a donut shape.
messages: Membrane
messages: P-body
messages: Probably involved with other LSm subunits in the general process of degradation of mRNAs.

8364:slc25a48
gene id: 8364:slc25a48
uniprot id: A0A803JSE9
uniprot id: A0A803KHI9
uniprot id: F6VT64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:dpep1
gene id: 8364:dpep1
uniprot id: A0A8J0QKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
messages: Membrane

8364:stxbp2
gene id: 8364:stxbp2
uniprot id: Q6DJA6
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

8364:pla1a
gene id: 8364:pla1a
uniprot id: A0A803JSW8
uniprot id: A0A8J1J356
uniprot id: A0A8J1J6K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8364:b4gat1
gene id: 8364:b4gat1
uniprot id: A0A803J9E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:sgsm3
gene id: 8364:sgsm3
uniprot id: F6SBM9
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

8364:jakmip3
gene id: 8364:jakmip3
uniprot id: A0A8J1JWM3
uniprot id: A0A8J1K0Q8
uniprot id: F7E6I3
names: Similarity
messages: Belongs to the JAKMIP family.

8364:LOC105948102
gene id: 8364:LOC105948102
uniprot id: A0A8J1IS49
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cgn
gene id: 8364:cgn
uniprot id: B1WB65
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cingulin family.
messages: Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.
messages: It is uncertain whether Met-1 or Met-9 is the initiator.
messages: Parallel homodimer (By similarity). Interacts with TJP1/ZO1 and TJP2/ZO2 (By similarity).
messages: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier, possibly by linking ZO proteins to the actomyosin cytoskeleton.
messages: tight junction

8364:adgrl3
gene id: 8364:adgrl3
uniprot id: A0A803J489
uniprot id: A0A803JEA7
uniprot id: A0A803JXR0
uniprot id: A0A8J1JNM9
uniprot id: A0A8J1JSD2
names: Subcellular Location Annotation
messages: Membrane

8364:cfap97d1
gene id: 8364:cfap97d1
uniprot id: F6RL00
uniprot id: Q6P374
names: Similarity
messages: Belongs to the CFAP97 family.

8364:tomm22
gene id: 8364:tomm22
uniprot id: Q28BJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

8364:fbn2
gene id: 8364:fbn2
uniprot id: F6WQA1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:themis2
gene id: 8364:themis2
uniprot id: F7AUV6
names: Similarity
messages: Belongs to the themis family.

8364:gje1
gene id: 8364:gje1
uniprot id: A0A803KD34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:nav3
gene id: 8364:nav3
uniprot id: A0A6I8SCX1
uniprot id: A0A8J1JA99
uniprot id: A0A8J1JCR4
uniprot id: A0A8J1JCS1
uniprot id: A0A8J1JDT0
uniprot id: F6YVA0
names: Similarity
messages: Belongs to the Nav/unc-53 family.

8364:h1-3
gene id: 8364:h1-3
uniprot id: Q28FT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:prl.2
gene id: 8364:prl.2
uniprot id: A0A6I8RB89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

8364:MGC147631
gene id: 8364:MGC147631
uniprot id: Q08CW4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8364:spin1
gene id: 8364:spin1
uniprot id: A9ULI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

8364:laptm4a
gene id: 8364:laptm4a
uniprot id: Q6GLF6
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

8364:42Sp50
gene id: 8364:42Sp50
uniprot id: Q5I0C1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8364:LOC100170623
gene id: 8364:LOC100170623
uniprot id: A0A8J1J5I6
uniprot id: A0A8J1J5J1
uniprot id: A0A8J1J5J2
uniprot id: A0A8J1J5J4
uniprot id: A0A8J1J5J5
uniprot id: A0A8J1J5J7
uniprot id: A0A8J1J5J9
uniprot id: A0A8J1J5K1
uniprot id: A0A8J1J5K2
uniprot id: A0A8J1J5K3
uniprot id: A0A8J1J5K6
uniprot id: A0A8J1J5K7
uniprot id: A0A8J1J5K8
uniprot id: A0A8J1J5L1
uniprot id: A0A8J1J5L2
uniprot id: A0A8J1J5L7
uniprot id: A0A8J1J5L8
uniprot id: A0A8J1J7Z0
uniprot id: A0A8J1J7Z5
uniprot id: A0A8J1J800
uniprot id: A0A8J1J811
uniprot id: A0A8J1J816
uniprot id: A0A8J1J8Z6
uniprot id: A0A8J1J902
uniprot id: A0A8J1J909
uniprot id: A0A8J1J915
uniprot id: A0A8J1J920
uniprot id: A0A8J1J924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

8364:pomt1
gene id: 8364:pomt1
uniprot id: F6YEH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

8364:npy5r
gene id: 8364:npy5r
uniprot id: F7A901
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

8364:scml4
gene id: 8364:scml4
uniprot id: A0A803J2M5
uniprot id: A0A8J1JN82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

8364:hoxb9
gene id: 8364:hoxb9
uniprot id: Q6PBD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

8364:ccdc86
gene id: 8364:ccdc86
uniprot id: A0A6I8Q1F1
names: Subcellular Location Annotation
messages: Nucleus

8364:crp.1
gene id: 8364:crp.1
uniprot id: F6V5K4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:eif4e3
gene id: 8364:eif4e3
uniprot id: B1WAS5
uniprot id: Q28ET8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity).

8364:LOC101731897
gene id: 8364:LOC101731897
uniprot id: A0A6I8SFV2
uniprot id: F7EU05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:adamts20
gene id: 8364:adamts20
uniprot id: A0A8J0QMJ1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:cyp2a6.2
gene id: 8364:cyp2a6.2
uniprot id: A0A8J1K0I9
uniprot id: A8E5W6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:sft2d2
gene id: 8364:sft2d2
uniprot id: Q28H00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

8364:rpl35
gene id: 8364:rpl35
uniprot id: B0JZY7
uniprot id: Q6PBC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8364:LOC100125049
gene id: 8364:LOC100125049
uniprot id: A4IIS5
names: Subcellular Location Annotation
messages: Membrane

8364:arl11
gene id: 8364:arl11
uniprot id: F6RGT2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8364:mmp7
gene id: 8364:mmp7
uniprot id: Q6DF35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Secreted

8364:xpo1
gene id: 8364:xpo1
uniprot id: A0A8J0QZP3
uniprot id: F7EP94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

8364:cuzd1
gene id: 8364:cuzd1
uniprot id: A0A6I8PTV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116406475
gene id: 8364:LOC116406475
uniprot id: A0A8J1ITQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:osgepl1
gene id: 8364:osgepl1
uniprot id: A0A8J1ISL6
uniprot id: Q0P4K0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

8364:LOC101731584
gene id: 8364:LOC101731584
uniprot id: A0A8J1J951
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:alad
gene id: 8364:alad
uniprot id: Q0VGV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

8364:tpmt
gene id: 8364:tpmt
uniprot id: B1H0Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm

8364:nmu
gene id: 8364:nmu
uniprot id: A0A803J404
uniprot id: A0A8J0R0N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

8364:LOC100494108
gene id: 8364:LOC100494108
uniprot id: A0A8J1JLH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

8364:LOC116411761
gene id: 8364:LOC116411761
uniprot id: A0A8J1JRF5
names: Similarity
messages: Belongs to the UPF0598 family.

8364:LOC116409559
gene id: 8364:LOC116409559
uniprot id: A0A8J1JAQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ccnb1.2
gene id: 8364:ccnb1.2
uniprot id: Q6P801
names: Similarity
messages: Belongs to the cyclin family.

8364:ndufa8
gene id: 8364:ndufa8
uniprot id: A4IHB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

8364:cmtm3
gene id: 8364:cmtm3
uniprot id: F6TFQ6
names: Subcellular Location Annotation
messages: Membrane

8364:ccn4
gene id: 8364:ccn4
uniprot id: F6UBU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:inka1
gene id: 8364:inka1
uniprot id: A4IHL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

8364:arhgef3.2
gene id: 8364:arhgef3.2
uniprot id: A0A6I8SM13
uniprot id: A0A6I8SV86
uniprot id: A0A7D9NKU0
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

8364:LOC100486720
gene id: 8364:LOC100486720
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116407586
gene id: 8364:LOC116407586
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:hcar2
gene id: 8364:hcar2
uniprot id: A0A8J0QUW6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:ezh1
gene id: 8364:ezh1
uniprot id: A0A6I8R8E5
names: Subcellular Location Annotation
messages: Nucleus

8364:rnf181
gene id: 8364:rnf181
uniprot id: Q5M974
names: Function
names: Similarity
messages: Belongs to the RNF181 family.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1.

8364:LOC105946953
gene id: 8364:LOC105946953
uniprot id: A0A8J1J8E3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:fzd5
gene id: 8364:fzd5
uniprot id: A0A803K619
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

8364:LOC101734839
gene id: 8364:LOC101734839
uniprot id: A0A8J0SXW8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:gadd45gip1
gene id: 8364:gadd45gip1
uniprot id: Q28D76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

8364:ctu2
gene id: 8364:ctu2
uniprot id: A0A4X2Q847
uniprot id: A0A8J1JDG3
uniprot id: Q28ES8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.

8364:pdpk1
gene id: 8364:pdpk1
uniprot id: A0A6I8QZN8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

8364:LOC101731523
gene id: 8364:LOC101731523
uniprot id: A0A803JM28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

8364:dcp1a
gene id: 8364:dcp1a
uniprot id: F7BGM2
names: Similarity
messages: Belongs to the DCP1 family.

8364:mcm5
gene id: 8364:mcm5
uniprot id: Q561P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the mcm2-7 complex (RLF-M). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5. The heterodimer of mmcm3/mcm5 interacts with mcm4, mmcm6, mcm7 and weakly with mcm2. Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45.
messages: Nucleus

8364:LOC116408615
gene id: 8364:LOC116408615
uniprot id: A0A8J1J2P3
names: Subcellular Location Annotation
messages: Membrane

8364:hoxa13
gene id: 8364:hoxa13
uniprot id: A0A803J783
uniprot id: F7AFD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Belongs to the protein kinase superfamily.
messages: Nucleus

8364:aoc1
gene id: 8364:aoc1
uniprot id: F6UW34
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

8364:acan
gene id: 8364:acan
uniprot id: A0A8J0SZN4
uniprot id: A0A8J1JB45
uniprot id: A0A8J1JDL0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:LOC100489330
gene id: 8364:LOC100489330
uniprot id: A0A8J0R8J4
names: Subcellular Location Annotation
messages: Membrane

8364:MGC107969
gene id: 8364:MGC107969
uniprot id: Q5FVZ4
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:eya3
gene id: 8364:eya3
uniprot id: A0A8J0SY61
uniprot id: B1WAZ7
uniprot id: F7BR08
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

8364:inip
gene id: 8364:inip
uniprot id: A0A6I8RWB2
uniprot id: A0A803JL87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

8364:LOC116411631
gene id: 8364:LOC116411631
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:efnb2
gene id: 8364:efnb2
uniprot id: A0A803KK20
uniprot id: F6SI02
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:nefm
gene id: 8364:nefm
uniprot id: F6UGX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon
messages: cytoskeleton

8364:ism2
gene id: 8364:ism2
uniprot id: A0A6I8PMK0
uniprot id: B1WB37
names: Similarity
messages: Belongs to the isthmin family.

8364:zp4
gene id: 8364:zp4
uniprot id: Q8AWX4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:plk1
gene id: 8364:plk1
uniprot id: P62205
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by phosphorylation on Thr-201 during M phase.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Interacts with plk1 and kif2a. Interacts with fbxo5.
messages: Midbody
messages: Nucleus
messages: Plays multiple essential roles during mitosis. Phosphorylates the N-terminal domain of cdc25, which leads to cyclin b-cdc2 activation and mitotic entry. Also required for organization of bipolar spindles, and for exit from mitosis. Phosphorylates tpx2 (By similarity).
messages: Protein levels are down-regulated by proteasomal degradation in anaphase.
messages: centrosome
messages: spindle

8364:rpl15
gene id: 8364:rpl15
uniprot id: Q28GB4
uniprot id: Q5I028
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

8364:mst1
gene id: 8364:mst1
uniprot id: A0A6I8QWJ6
uniprot id: A0A8J1JGH5
uniprot id: A0A8J1JGH9
uniprot id: F7EDW8
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100494837
gene id: 8364:LOC100494837
uniprot id: A0A8J1JUF0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

8364:sec31b
gene id: 8364:sec31b
uniprot id: A0A6I8S8J8
uniprot id: F7BHH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

8364:LOC108645541
gene id: 8364:LOC108645541
uniprot id: A0A8J1J0Z4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:pxn
gene id: 8364:pxn
uniprot id: A0A8J1J2H6
uniprot id: B4F6K3
uniprot id: F7B727
names: Subcellular Location Annotation
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

8364:tenm1
gene id: 8364:tenm1
uniprot id: A0A6I8QJV4
uniprot id: A0A6I8QSZ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:gjb4
gene id: 8364:gjb4
uniprot id: A0A6I8Q3Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:sumf1
gene id: 8364:sumf1
uniprot id: A0A8J1JDH8
uniprot id: Q28H18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

8364:taf6
gene id: 8364:taf6
uniprot id: A0A8J1JBX5
uniprot id: A0A8J1JBX7
uniprot id: A0A8J1JEC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

8364:LOC100492100
gene id: 8364:LOC100492100
uniprot id: A0A8J1JGA5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ribc1
gene id: 8364:ribc1
uniprot id: B5DEV2
uniprot id: F6PII4
names: Similarity
messages: Belongs to the RIB43A family.

8364:LOC100492237
gene id: 8364:LOC100492237
uniprot id: A0A6I8SDD4
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8364:nedd8
gene id: 8364:nedd8
uniprot id: Q28E73
names: Similarity
messages: Belongs to the ubiquitin family.

8364:mocos
gene id: 8364:mocos
uniprot id: A0A8J0QUR6
uniprot id: A0A8J0T0H6
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

8364:gpm6b
gene id: 8364:gpm6b
uniprot id: A0A803KI96
uniprot id: Q0IHP9
uniprot id: Q28GS9
uniprot id: Q6DFR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

8364:LOC116410964
gene id: 8364:LOC116410964
uniprot id: A0A8J1JNF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

8364:hpcal4
gene id: 8364:hpcal4
uniprot id: Q0V9W7
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

8364:ier3ip1
gene id: 8364:ier3ip1
uniprot id: A0A803KDW3
names: Similarity
messages: Belongs to the YOS1 family.

8364:teddm1
gene id: 8364:teddm1
uniprot id: A0A803JH90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

8364:fbln5
gene id: 8364:fbln5
uniprot id: Q5BKG6
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116412140
gene id: 8364:LOC116412140
uniprot id: A0A8J1JUS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116411623
gene id: 8364:LOC116411623
uniprot id: A0A8J1JU85
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:wwc1
gene id: 8364:wwc1
uniprot id: A4IIJ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WWC family. KIBRA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: May play a role in the regulation of the Hippo signaling pathway.
messages: Nucleus
messages: The C2-domain mediates homodimerization.

8364:olfm4
gene id: 8364:olfm4
uniprot id: A0A8J0PIV0
uniprot id: A0A8J0SUV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gnpda1
gene id: 8364:gnpda1
uniprot id: F7B2V6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

8364:LOC100495442
gene id: 8364:LOC100495442
uniprot id: A0A803J411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

8364:rgs2
gene id: 8364:rgs2
uniprot id: Q5BKF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

8364:ctss
gene id: 8364:ctss
uniprot id: F6YLX6
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:dnah11
gene id: 8364:dnah11
uniprot id: A0A8J1JS97
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:atg3
gene id: 8364:atg3
uniprot id: Q5I0S6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG3 family.
messages: Conjugated to atg12 at Lys-241. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy (By similarity).
messages: Cytoplasm
messages: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of atg12 to itself, atg12 conjugation to atg3 playing a role in mitochondrial homeostasis but not in autophagy. atg7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with atg3 (By similarity).
messages: Interacts with atg7 and atg12. The complex composed of atg3 and atg7 plays a role in the conjugation of atg12 to atg5.

8364:dipk1a
gene id: 8364:dipk1a
uniprot id: A0A803J8H4
uniprot id: A4IGK1
uniprot id: F7DSB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

8364:dctpp1
gene id: 8364:dctpp1
uniprot id: A0A8J0PEH5
uniprot id: A0A8J0SNB7
uniprot id: Q66KE0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

8364:scamp2
gene id: 8364:scamp2
uniprot id: Q6NVP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

8364:LOC100145162
gene id: 8364:LOC100145162
uniprot id: A0A6I8QMN8
uniprot id: A0A8J0QG01
uniprot id: A0A8J1J1T8
names: Subcellular Location Annotation
messages: Nucleus

8364:ldha
gene id: 8364:ldha
uniprot id: Q6P7L5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

8364:olah
gene id: 8364:olah
uniprot id: Q6NVK7
names: Similarity
messages: Belongs to the thioesterase family.

8364:por
gene id: 8364:por
uniprot id: A0A6I8R571
uniprot id: A0A6I8RDV9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

8364:LOC100487203
gene id: 8364:LOC100487203
uniprot id: A0A6I8S4K8
names: Subcellular Location Annotation
messages: Membrane

8364:maob
gene id: 8364:maob
uniprot id: A0A6I8T0W6
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

8364:ttc19
gene id: 8364:ttc19
uniprot id: A0A8J0T0F4
uniprot id: F6R444
names: Similarity
messages: Belongs to the TTC19 family.

8364:p2ry1
gene id: 8364:p2ry1
uniprot id: Q0V9S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:lnpk
gene id: 8364:lnpk
uniprot id: A0A1L1M275
uniprot id: B7ZUP9
uniprot id: Q28HF6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network (By similarity).
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Phosphorylated. Phosphorylation at Thr-159 occurs during interphase. Phosphorylation at Ser-177, Ser-179, Ser-188, Thr-198, Ser-206, Ser-215, Thr-219, Ser-222 and Ser-231 occurs during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.
messages: The transmembrane domain 1 and 2 function as a signal-anchor and stop-transfer sequence, respectively, generating a double-spanning integral membrane protein with a N- and C-terminal cytoplasmic orientation. Transmembrane domain 1 and 2 are probably sufficient to mediate membrane translocation and topology formation in a N-myristoylation-independent manner. Transmembrane domain 2 is sufficient to block the protein secretion pathway. The two coiled-coil domains are necessary for its endoplasmic reticulum (ER) three-way tubular junction localization. The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

8364:adcyap1
gene id: 8364:adcyap1
uniprot id: A0A8J0SFE9
uniprot id: A4IIN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

8364:adgre5
gene id: 8364:adgre5
uniprot id: A0A8J1J8B9
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:rock2
gene id: 8364:rock2
uniprot id: A0A6I8RA74
uniprot id: A0A8J0QTP8
uniprot id: A0A8J0R1I4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
messages: centrosome

8364:gnrh1
gene id: 8364:gnrh1
uniprot id: A0A803KI17
uniprot id: F6TQV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins.

8364:LOC100497855
gene id: 8364:LOC100497855
uniprot id: A0A6I8R8S4
uniprot id: A0A8J0SA24
uniprot id: A0A8J0SGB5
uniprot id: A0A8J0SJ77
uniprot id: A0A8J1JB16
uniprot id: A0A8J1JB18
uniprot id: A0A8J1JB21
uniprot id: A0A8J1JB23
uniprot id: A0A8J1JDI3
uniprot id: A0A8J1JDI8
uniprot id: A0A8J1JEJ8
uniprot id: A0A8J1JEK3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

8364:rps9
gene id: 8364:rps9
uniprot id: Q6DFN8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

8364:alpi.2
gene id: 8364:alpi.2
uniprot id: A0A6I8RU07
uniprot id: B1WBG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

8364:ssx2ip
gene id: 8364:ssx2ip
uniprot id: A0A8J1JJ78
uniprot id: F6W4M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

8364:stip1
gene id: 8364:stip1
uniprot id: Q6P302
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC100498162
gene id: 8364:LOC100498162
uniprot id: A0A8J0QTG5
names: Subcellular Location Annotation
messages: extracellular space

8364:tcaf2
gene id: 8364:tcaf2
uniprot id: A0A6I8QBW4
uniprot id: A0A8J1JE97
names: Similarity
messages: Belongs to the TCAF family.

8364:s100a16
gene id: 8364:s100a16
uniprot id: A0A803JHX2
names: Similarity
messages: Belongs to the S-100 family.

8364:LOC100496673
gene id: 8364:LOC100496673
uniprot id: A0A803JUA3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:LOC100491631
gene id: 8364:LOC100491631
uniprot id: A0A8J0T1N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:serpinb11
gene id: 8364:serpinb11
uniprot id: F6W2F7
names: Similarity
messages: Belongs to the serpin family.

8364:aga
gene id: 8364:aga
uniprot id: A0A6I8SB37
uniprot id: F7DC69
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

8364:ntrk1
gene id: 8364:ntrk1
uniprot id: F6W3P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:dpagt1
gene id: 8364:dpagt1
uniprot id: F6ZLM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:vps53
gene id: 8364:vps53
uniprot id: A0A6I8QVJ7
uniprot id: F6RWV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

8364:LOC100498054
gene id: 8364:LOC100498054
uniprot id: A0A8J1JZA2
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100496982
gene id: 8364:LOC100496982
uniprot id: A0A8J1JLC7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116406428
gene id: 8364:LOC116406428
uniprot id: A0A803JF47
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:LOC116412378
gene id: 8364:LOC116412378
uniprot id: A0A8J1JZI1
names: Subcellular Location Annotation
messages: Cytoplasm

8364:nt5dc2
gene id: 8364:nt5dc2
uniprot id: A4IID9
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

8364:selenbp1
gene id: 8364:selenbp1
uniprot id: A0A1B8Y1Y9
uniprot id: Q28CY4
uniprot id: Q569D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (By similarity). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Membrane
messages: Nucleus
messages: cytosol

8364:tsg101
gene id: 8364:tsg101
uniprot id: A0A8J1JD66
uniprot id: Q6P2Z8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

8364:sigirr
gene id: 8364:sigirr
uniprot id: F7B7F9
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8364:LOC101731852
gene id: 8364:LOC101731852
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:cep78
gene id: 8364:cep78
uniprot id: A2RRS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP78 family.
messages: May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis.
messages: centriole
messages: centrosome
messages: cilium basal body

8364:lig4
gene id: 8364:lig4
uniprot id: Q28EB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

8364:LOC100491943
gene id: 8364:LOC100491943
uniprot id: A0A803J7I9
uniprot id: A0A8J1JIM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

8364:pard6b
gene id: 8364:pard6b
uniprot id: B3DM40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

8364:t2r17
gene id: 8364:t2r17
uniprot id: A0A803KK99
uniprot id: F7D4J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:tpra1
gene id: 8364:tpra1
uniprot id: A0A6I8Q7B3
uniprot id: B3DLW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

8364:derl2
gene id: 8364:derl2
uniprot id: Q28F56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:cmc4
gene id: 8364:cmc4
uniprot id: A0A8J0R6M7
names: Similarity
messages: Belongs to the CMC4 family.

8364:slc40a1
gene id: 8364:slc40a1
uniprot id: A0A803KGX9
uniprot id: A0A8J1IUX9
uniprot id: F6RQW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

8364:prokr2
gene id: 8364:prokr2
uniprot id: A0A8J0T2Y3
uniprot id: F7DS03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:c1h12orf43
gene id: 8364:c1h12orf43
uniprot id: A0A6I8RTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUSTOS family.
messages: Nucleus envelope

8364:ace2
gene id: 8364:ace2
uniprot id: A0A6I8R2Q4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

8364:cdh4
gene id: 8364:cdh4
uniprot id: A0A803KDA3
uniprot id: A0A8J1IYJ6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8364:slc6a6
gene id: 8364:slc6a6
uniprot id: A0A6I8QRW3
uniprot id: A0A6I8S368
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

8364:hoxc4
gene id: 8364:hoxc4
uniprot id: A0A6I8RGQ5
uniprot id: A0A803JCC3
uniprot id: F6WP27
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8364:slc39a3
gene id: 8364:slc39a3
uniprot id: A0A803JDY2
uniprot id: A4IIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a zinc-influx transporter.
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

8364:rps6ka6
gene id: 8364:rps6ka6
uniprot id: A0A6I8QSE5
uniprot id: A0A8J1IU12
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8364:abhd12
gene id: 8364:abhd12
uniprot id: B4F753
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity).

8364:LOC100487855
gene id: 8364:LOC100487855
uniprot id: A0A803K8Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

8364:ap4m1
gene id: 8364:ap4m1
uniprot id: A8E5U8
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

8364:LOC116411533
gene id: 8364:LOC116411533
uniprot id: A0A8J1JPM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:foxd4l1.2
gene id: 8364:foxd4l1.2
uniprot id: F6XIK9
names: Subcellular Location Annotation
messages: Nucleus

8364:acsl1
gene id: 8364:acsl1
uniprot id: A0A6I8R975
uniprot id: Q6DF45
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

8364:LOC100498389
gene id: 8364:LOC100498389
uniprot id: A0A1B8Y8P4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

8364:LOC100489544
gene id: 8364:LOC100489544
uniprot id: A0A8J0QYJ7
names: Subcellular Location Annotation
messages: Membrane

8364:hcrtr2
gene id: 8364:hcrtr2
uniprot id: F6RCR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cnih3
gene id: 8364:cnih3
uniprot id: A0A803JF51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

8364:ca1
gene id: 8364:ca1
uniprot id: F6ZUY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

8364:ndufv1
gene id: 8364:ndufv1
uniprot id: A0A6I8Q501
uniprot id: F6WDT0
uniprot id: Q5HZV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

8364:oit3
gene id: 8364:oit3
uniprot id: F7E3F0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tnfrsf6b
gene id: 8364:tnfrsf6b
uniprot id: B1WBK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:nop56
gene id: 8364:nop56
uniprot id: A0A8J0QFH3
uniprot id: Q28GZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

8364:LOC101733405
gene id: 8364:LOC101733405
uniprot id: A0A8J0T3S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:sia2
gene id: 8364:sia2
uniprot id: A0A1B4ZDM5
names: Subcellular Location Annotation
messages: Nucleus

8364:cxxc1
gene id: 8364:cxxc1
uniprot id: A0A8J1INU3
uniprot id: A0A8J1IRZ3
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC594879
gene id: 8364:LOC594879
uniprot id: A0A8J0QFY4
uniprot id: F6RRF5
uniprot id: Q5BKI3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

8364:cog2
gene id: 8364:cog2
uniprot id: A0A8J0QKS9
uniprot id: F7BFE3
names: Similarity
messages: Belongs to the COG2 family.

8364:tp73
gene id: 8364:tp73
uniprot id: A0A6I8QCA0
uniprot id: A0A6I8QZI1
uniprot id: A0A8J1JV73
uniprot id: A0A8J1JV77
uniprot id: A0A8J1JXN0
uniprot id: A0A8J1JZ54
uniprot id: F6TKT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Found in a complex with p53/TP53 and CABLES1.
messages: Nucleus
messages: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

8364:gpr4
gene id: 8364:gpr4
uniprot id: A0A6I8PUB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dyrk1a
gene id: 8364:dyrk1a
uniprot id: A0A6I8QSK6
uniprot id: F6QKT7
uniprot id: Q0IJ08
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated on tyrosine residues.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The histidine-rich domain (HRD) region is intrinsically disordered and promotes the formation of phase-separated liquid droplets that enhance its ability to phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).

8364:LOC116406806
gene id: 8364:LOC116406806
uniprot id: A0A8J1IPR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100492564
gene id: 8364:LOC100492564
uniprot id: A0A8J0QXA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:gip
gene id: 8364:gip
uniprot id: A0A6I8PZZ0
uniprot id: A1DPK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

8364:cnot1
gene id: 8364:cnot1
uniprot id: A0JP85
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT1 family.
messages: Component of the CCR4-NOT complex.
messages: Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).

8364:LOC100496754
gene id: 8364:LOC100496754
uniprot id: A0A8J0SBW8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pde6g
gene id: 8364:pde6g
uniprot id: A4IHC2
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

8364:cdh20
gene id: 8364:cdh20
uniprot id: A0A8J0SQQ0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8364:foxk2
gene id: 8364:foxk2
uniprot id: A0A803JVT1
uniprot id: B5DE12
names: Subcellular Location Annotation
messages: Nucleus

8364:ikbkb
gene id: 8364:ikbkb
uniprot id: A0A8J0T101
uniprot id: F7A2B9
uniprot id: Q6GL53
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:sf3b4
gene id: 8364:sf3b4
uniprot id: Q6P872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

8364:ccl4
gene id: 8364:ccl4
uniprot id: A0A8J0QRG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

8364:ccs
gene id: 8364:ccs
uniprot id: Q63ZZ7
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

8364:alg10
gene id: 8364:alg10
uniprot id: Q08D71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

8364:fnbp1l
gene id: 8364:fnbp1l
uniprot id: A0A6I8Q9A3
uniprot id: A0A8J1JDA9
uniprot id: Q6GUF4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts with GTP-bound cdc42 and wasl/n-wasp (By similarity).
messages: Membrane
messages: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Promotes cdc42-induced actin polymerization by activating the wasl-waspip complex, the predominant form of wasl/n-wasp in cells. Essential for autophagy of intracellular bacterial pathogens (By similarity).
messages: The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation (By similarity).
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

8364:tyrp1
gene id: 8364:tyrp1
uniprot id: Q28HG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8364:ndufa3
gene id: 8364:ndufa3
uniprot id: A0A8J0PJF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

8364:hpd
gene id: 8364:hpd
uniprot id: Q0IIY1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

8364:lox
gene id: 8364:lox
uniprot id: A0A8J0SPC6
uniprot id: A0A8J0SRZ3
uniprot id: F6TT35
uniprot id: Q0IHS3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

8364:usp37
gene id: 8364:usp37
uniprot id: A0A6I8Q2J8
uniprot id: A0A6I8SW45
uniprot id: F7DC76
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:cd302
gene id: 8364:cd302
uniprot id: A0A8J1IVW3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:atxn1
gene id: 8364:atxn1
uniprot id: A0A8J0SQN8
uniprot id: F6PW06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

8364:zc3h15
gene id: 8364:zc3h15
uniprot id: A0A4X2QBT9
uniprot id: A4IGY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZC3H15/TMA46 family.
messages: Cytoplasm
messages: Interacts with drg1.
messages: Nucleus
messages: Protects drg1 from proteolytic degradation.

8364:LOC100493515
gene id: 8364:LOC100493515
uniprot id: F6YKY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:park7
gene id: 8364:park7
uniprot id: Q5CZZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

8364:coro6
gene id: 8364:coro6
uniprot id: A0A803KLI6
uniprot id: B1H1C2
names: Similarity
messages: Belongs to the WD repeat coronin family.

8364:vsx1
gene id: 8364:vsx1
uniprot id: A4IHP1
names: Subcellular Location Annotation
messages: Nucleus

8364:pax8
gene id: 8364:pax8
uniprot id: A0A6I8R3D8
uniprot id: A0A8J0S9V0
uniprot id: A0A8J0SG14
uniprot id: A0A8J0SS60
uniprot id: A0A8J1J7V1
uniprot id: A0A8J1JAA2
uniprot id: A0A8J1JBB8
uniprot id: A0JMA6
uniprot id: F6X1V2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 to establish the pronephric primordium in late gastrulae/early neurulae (By similarity).

8364:chrdl2
gene id: 8364:chrdl2
uniprot id: A0A803KBY6
names: Subcellular Location Annotation
messages: Secreted

8364:mxd1
gene id: 8364:mxd1
uniprot id: Q0VFI9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity).
messages: Nucleus
messages: Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX (By similarity).

8364:jag1
gene id: 8364:jag1
uniprot id: A0A6I8SCZ7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8364:epc1
gene id: 8364:epc1
uniprot id: A0A7D9NLJ0
uniprot id: A0A8J1JQY3
uniprot id: A0JP73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

8364:sdr42e2
gene id: 8364:sdr42e2
uniprot id: A0A6I8PZ34
names: Similarity
messages: Belongs to the 3-beta-HSD family.

8364:eif3f
gene id: 8364:eif3f
uniprot id: A0A8J0PHS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8364:gpc2
gene id: 8364:gpc2
uniprot id: A0A803K5U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

8364:otop2
gene id: 8364:otop2
uniprot id: A0A6I8S9L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:fam221a
gene id: 8364:fam221a
uniprot id: A0A8J0SGA7
uniprot id: A0A8J0SQX3
uniprot id: B0BMN2
uniprot id: Q28J59
names: Similarity
messages: Belongs to the FAM221 family.

8364:hs2st1
gene id: 8364:hs2st1
uniprot id: B1H370
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

8364:mesd
gene id: 8364:mesd
uniprot id: F6PYD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

8364:cdk10
gene id: 8364:cdk10
uniprot id: Q28I12
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC101732699
gene id: 8364:LOC101732699
uniprot id: A0A8J0SXM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:LOC116412172
gene id: 8364:LOC116412172
uniprot id: A0A8J1JYS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:itgb2
gene id: 8364:itgb2
uniprot id: A0A6I8Q6V6
uniprot id: A0A6I8QRV5
uniprot id: A0A8J0SWC1
uniprot id: A0A8J1ITT0
uniprot id: A0A8J1ITT3
uniprot id: A0A8J1ITT8
uniprot id: A0A8J1ITU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

8364:LOC101731982
gene id: 8364:LOC101731982
uniprot id: A0A8J1JSR4
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100379837
gene id: 8364:LOC100379837
uniprot id: A0A6I8QHZ9
uniprot id: A0A6I8QPZ0
uniprot id: A0A8J0QXA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

8364:cacng5
gene id: 8364:cacng5
uniprot id: A0A803JF33
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

8364:prkar2a
gene id: 8364:prkar2a
uniprot id: A0A6I8Q2A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

8364:fgfbp2
gene id: 8364:fgfbp2
uniprot id: A0A803K540
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

8364:hus1
gene id: 8364:hus1
uniprot id: Q6DF51
names: Similarity
messages: Belongs to the HUS1 family.

8364:LOC116412040
gene id: 8364:LOC116412040
uniprot id: A0A8J1JTN7
uniprot id: A0A8J1JXH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:ppp4r2
gene id: 8364:ppp4r2
uniprot id: Q28IG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP4R2 family.
messages: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

8364:coe3l
gene id: 8364:coe3l
uniprot id: A0A6I8RCH8
uniprot id: A0A8J1IZV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

8364:rpl11
gene id: 8364:rpl11
uniprot id: A0A8J0SCP1
uniprot id: A4IHG9
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

8364:LOC101732809
gene id: 8364:LOC101732809
uniprot id: A0A6I8Q9X7
uniprot id: A0A8J0R571
uniprot id: F6SKP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane
messages: Nucleus

8364:LOC100495963
gene id: 8364:LOC100495963
uniprot id: A0A8J1J722
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

8364:gpr68
gene id: 8364:gpr68
uniprot id: F7AA76
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:rif1
gene id: 8364:rif1
uniprot id: A0A6I8SJ33
uniprot id: A0A8J0R2S9
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

8364:gpr183.1
gene id: 8364:gpr183.1
uniprot id: A0A8J0T146
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC116406823
gene id: 8364:LOC116406823
uniprot id: A0A8J1IPU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ada
gene id: 8364:ada
uniprot id: F6RPM0
uniprot id: Q63ZU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity).
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle lumen
messages: Lysosome

8364:fut7
gene id: 8364:fut7
uniprot id: A0A8J0SMF0
uniprot id: Q49ME6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8364:fah
gene id: 8364:fah
uniprot id: A9UMK8
names: Similarity
messages: Belongs to the FAH family.

8364:plpp4
gene id: 8364:plpp4
uniprot id: A0A6I8RHC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8364:LOC101734901
gene id: 8364:LOC101734901
uniprot id: A0A8J1JTN4
uniprot id: A0A8J1JW43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:nkrf
gene id: 8364:nkrf
uniprot id: Q28C35
names: Similarity
messages: Belongs to the CARF family.

8364:LOC100485404
gene id: 8364:LOC100485404
uniprot id: A0A8J0QY32
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8364:LOC116406805
gene id: 8364:LOC116406805
uniprot id: A0A8J1IPQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC105945914
gene id: 8364:LOC105945914
uniprot id: A0A8J1JWU9
names: Similarity
messages: Belongs to the leprecan family.

8364:esrp1
gene id: 8364:esrp1
uniprot id: A0A8J0SMZ0
uniprot id: A0A8J0SQT0
uniprot id: Q6DEZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus
messages: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity).

8364:fam162b
gene id: 8364:fam162b
uniprot id: A0A6I8S9W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

8364:nmt2
gene id: 8364:nmt2
uniprot id: Q0IJ16
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

8364:tcta
gene id: 8364:tcta
uniprot id: A4IHD1
uniprot id: A9JTV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: Membrane

8364:nudt21
gene id: 8364:nudt21
uniprot id: Q28J89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

8364:dr1
gene id: 8364:dr1
uniprot id: F7DWV2
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

8364:ddx6
gene id: 8364:ddx6
uniprot id: Q0IHV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase that is an integral component of messenger ribonucleoprotein complexes (mRNPs), storage particles that mask maternal mRNAs from the translational apparatus during oocyte maturation.
messages: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
messages: Component of a ribonucleoprotein (RNP) complex, composed at least of cpeb1, lsm14b/rap55b, ddx6/Xp54, ybx2/frgy2, pat1/P100, eif4enif1/4E-T and eif4e1b. Component of a ribonucleoprotein (RNP) complex, composed at least of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen. Component of a ribonucleoprotein (RNP) complex, composed at least of lsm14a/rap55a, ybx2/frgy2, ddx6/Xp54 and eif4enif1/4E-T. Interacts with lsm14a/rap55a (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: P-body

8364:prok2
gene id: 8364:prok2
uniprot id: A0A8J0QUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

8364:LOC105945576
gene id: 8364:LOC105945576
uniprot id: A0A8J1JNM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:krt15.2
gene id: 8364:krt15.2
uniprot id: F7AZ32
names: Similarity
messages: Belongs to the intermediate filament family.

8364:stag2
gene id: 8364:stag2
uniprot id: A0A6I8SSL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

8364:plcb1
gene id: 8364:plcb1
uniprot id: A0A6I8SDL6
uniprot id: A0A8J1JIJ5
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

8364:ptpn12
gene id: 8364:ptpn12
uniprot id: Q569D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

8364:inpp1
gene id: 8364:inpp1
uniprot id: B0JZU3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8364:dazl
gene id: 8364:dazl
uniprot id: A0A803J6Z2
uniprot id: Q76CY5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM DAZ family.
messages: Cytoplasm
messages: Expressed constantly during oogenesis from the previtellogenic (stage I) oocyte to the mature (stage VI) oocyte, and after fertilization until the early tadpole stage.
messages: Germ-line specific; expressed in adult testis and ovary. Localized specifically to the oocyte and embryonic germ plasm and to migrating primordial germ cells (PGCs).
messages: Interacts with the C-terminus of pabp1 and with epabp. Prior to oocyte maturation, found in a complex with epabp and pum2 proteins and spdy1 mRNA; pum2 dissociates from the complex during maturation (By similarity).
messages: RNA-binding protein that is required for primordial germ cell (PGC) differentiation and indirectly necessary for the migration of PGCs through the endoderm. May promote meiotic cell division during spermatogenesis. Shows a preference for G- and U-rich RNAs and probably binds the 3'-UTR of target mRNAs. Stimulates the initiation of translation of mRNAs through the recruitment of poly(A)-binding proteins (PABPs) (By similarity).

8364:tssc4
gene id: 8364:tssc4
uniprot id: A0A803KIR9
uniprot id: Q0IHP0
names: Similarity
messages: Belongs to the TSSC4 family.

8364:sesn1
gene id: 8364:sesn1
uniprot id: B3DLB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

8364:tm7sf2
gene id: 8364:tm7sf2
uniprot id: A0A8J1JCP3
uniprot id: A9JTP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

8364:cpt1a
gene id: 8364:cpt1a
uniprot id: A0A6I8QNQ8
uniprot id: F7CNI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

8364:LOC100495200
gene id: 8364:LOC100495200
uniprot id: A0A8J0R530
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:ubqln1
gene id: 8364:ubqln1
uniprot id: A0A8J1J7T3
uniprot id: F6RXL5
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

8364:rrp7a
gene id: 8364:rrp7a
uniprot id: A0A8J0QP48
uniprot id: F7BZL7
names: Similarity
messages: Belongs to the RRP7 family.

8364:tm6sf2
gene id: 8364:tm6sf2
uniprot id: B2GUH8
names: Subcellular Location Annotation
messages: Membrane

8364:polr3k
gene id: 8364:polr3k
uniprot id: Q5FVV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

8364:pclo
gene id: 8364:pclo
uniprot id: A0A6I8Q0Z4
uniprot id: A0A6I8S477
uniprot id: A0A6I8SIJ8
uniprot id: A0A8J1JAJ1
uniprot id: A0A8J1JAJ3
uniprot id: A0A8J1JAK1
names: Subcellular Location Annotation
messages: Presynaptic active zone

8364:myod1
gene id: 8364:myod1
uniprot id: Q7T109
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8364:ndufs4
gene id: 8364:ndufs4
uniprot id: A0A6I8PQR2
uniprot id: A0A8J0QXH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mitochondrion inner membrane

8364:dcbld1
gene id: 8364:dcbld1
uniprot id: A0A8J0SDY3
uniprot id: A0A8J1JHZ8
uniprot id: Q6GL27
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:yod1
gene id: 8364:yod1
uniprot id: F7ECX1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

8364:mboat4
gene id: 8364:mboat4
uniprot id: A0A8J0QRF0
names: Subcellular Location Annotation
messages: Membrane

8364:aurka
gene id: 8364:aurka
uniprot id: Q28HZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

8364:gpn1
gene id: 8364:gpn1
uniprot id: A4IH64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

8364:LOC100495967
gene id: 8364:LOC100495967
uniprot id: A0A803JDB2
uniprot id: F7D6U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:panx1
gene id: 8364:panx1
uniprot id: B3DLA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

8364:KEG17 p09
gene id: 8364:KEG17_p09
uniprot id: Q5G7I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrion membrane

8364:gsg1l
gene id: 8364:gsg1l
uniprot id: F6XCN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

8364:lmbr1l
gene id: 8364:lmbr1l
uniprot id: A0A6I8RJ68
uniprot id: F6YTE9
names: Similarity
messages: Belongs to the LIMR family.

8364:pgam2
gene id: 8364:pgam2
uniprot id: F6ZRC3
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

8364:sult6b1.4
gene id: 8364:sult6b1.4
uniprot id: F7A3C3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:kif26b
gene id: 8364:kif26b
uniprot id: A0A6I8RUH2
uniprot id: A0A8J0QJU2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:tcf25
gene id: 8364:tcf25
uniprot id: Q0VA28
names: Similarity
messages: Belongs to the TCF25 family.

8364:sdhb
gene id: 8364:sdhb
uniprot id: B0BM36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

8364:dact3
gene id: 8364:dact3
uniprot id: A0A6I8RN91
uniprot id: A0A8J0QJA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Belongs to the dapper family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:LOC100145082
gene id: 8364:LOC100145082
uniprot id: A0A803JBB7
uniprot id: A0A8J1IRY6
uniprot id: B0BMP3
uniprot id: F7ESN7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:aspdh
gene id: 8364:aspdh
uniprot id: A0A803JQG5
uniprot id: Q5FW48
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

8364:nipbl
gene id: 8364:nipbl
uniprot id: A0A6I8SA48
uniprot id: A0A8J0SZY5
uniprot id: F6TRY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

8364:rab7b
gene id: 8364:rab7b
uniprot id: F7BQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

8364:nkx6-1
gene id: 8364:nkx6-1
uniprot id: A5YC50
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100494827
gene id: 8364:LOC100494827
uniprot id: A0A8J1JC07
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:sema3d
gene id: 8364:sema3d
uniprot id: A0A8J0QPU1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tfb1m
gene id: 8364:tfb1m
uniprot id: B7ZTC1
uniprot id: F6THF5
uniprot id: Q28HM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
messages: Mitochondrion
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Stimulates transcription independently of the methyltransferase activity (By similarity).

8364:calhm4
gene id: 8364:calhm4
uniprot id: A0A6I8PXK7
uniprot id: F6Y7C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:snx21
gene id: 8364:snx21
uniprot id: A0A8J0S591
uniprot id: A0A8J0S594
uniprot id: A0A8J0S9F2
uniprot id: A0A8J0SAZ1
uniprot id: A0A8J0SBJ3
uniprot id: A0A8J0SBX5
uniprot id: A0A8J1IWN1
uniprot id: A0A8J1IZU9
uniprot id: Q28E52
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Membrane

8364:eif4ebp2
gene id: 8364:eif4ebp2
uniprot id: F7BX46
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

8364:ahdc1
gene id: 8364:ahdc1
uniprot id: F6U3B0
names: Subcellular Location Annotation
messages: Nucleus

8364:zic3
gene id: 8364:zic3
uniprot id: Q6DJQ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus
messages: Probably acts as a transcriptional activator. May bind to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development. Involved in establishing left-right asymmetry in the embryo (By similarity).
messages: The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation. The zinc fingers and the N-terminus are independently important for establishing the L/R axis (By similarity).

8364:loxl1
gene id: 8364:loxl1
uniprot id: A4IHQ3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

8364:rpap3
gene id: 8364:rpap3
uniprot id: Q28IV3
names: Function
names: Similarity
messages: Belongs to the RPAP3 family.
messages: May for an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein.

8364:ca2
gene id: 8364:ca2
uniprot id: Q5FW20
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:LOC101730485
gene id: 8364:LOC101730485
uniprot id: A0A8J1IMM9
names: Similarity
messages: Belongs to the mitoguardin family.

8364:cops6
gene id: 8364:cops6
uniprot id: A0A1B8Y936
uniprot id: Q07G98
uniprot id: Q6DIS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the catalytic center and therefore it probably does not have a protease activity.
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Nucleus

8364:id3
gene id: 8364:id3
uniprot id: Q688C4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer (By similarity). Heterodimer with other HLH proteins. Interacts (via HLH domain) with the bHLH protein hes4/hairy2 (via Orange domain). Interacts with stat3 (By similarity).
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Influences cell fate decisions in the embryo by sequestering and blocking the activity of the bHLH transcription factors that control these decisions. Inhibits the binding of myogenic bHLH-containing complexes to E-box DNA, thereby preventing activation of muscle-specific target genes. Also inhibits the activity of neurogenic factor neurod1/neuroD. Plays a role in cell cycle progression and survival of neural crest progenitors; binding to either hes4-B/hairy2b or stat3 blocks the formation of transcription factor complexes and the repressor function of hes4-B/hairy2B, to allow neural crest progenitors to differentiate. May play a role in the regulation of the circadian rhythm (By similarity).

8364:cuta
gene id: 8364:cuta
uniprot id: F7BR45
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

8364:lpl
gene id: 8364:lpl
uniprot id: F7E1R2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

8364:zdhhc15
gene id: 8364:zdhhc15
uniprot id: A0A6I8T122
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:nifk
gene id: 8364:nifk
uniprot id: Q6GL69
names: Subcellular Location Annotation
messages: nucleolus

8364:grb2
gene id: 8364:grb2
uniprot id: A0A6I8RYF1
uniprot id: Q66II3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Promotes meiotic reinitiation during oocyte maturation.
messages: Cytoplasm
messages: Endosome
messages: Golgi apparatus
messages: Nucleus
messages: The two SH3 domains and the SH2 domain are necessary for the reinitiation of oocyte meiosis.

8364:arpc5
gene id: 8364:arpc5
uniprot id: Q28IX9
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

8364:chrnd
gene id: 8364:chrnd
uniprot id: Q5EB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:LOC105946681
gene id: 8364:LOC105946681
uniprot id: A0A8J0SEC1
names: Similarity
messages: Belongs to the cyclin family.

8364:psmc3
gene id: 8364:psmc3
uniprot id: Q6DIE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

8364:arf4
gene id: 8364:arf4
uniprot id: Q5BJ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

8364:impa1
gene id: 8364:impa1
uniprot id: A0A8J0SR63
uniprot id: Q28FW1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8364:rag2
gene id: 8364:rag2
uniprot id: F6Q0Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

8364:LOC100497718
gene id: 8364:LOC100497718
uniprot id: A0A8J1JL17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

8364:washc3
gene id: 8364:washc3
uniprot id: A0A6I8QF64
names: Similarity
messages: Belongs to the CCDC53 family.

8364:tp53inp2
gene id: 8364:tp53inp2
uniprot id: A0A803KF13
uniprot id: F6XUT0
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

8364:chmp2a
gene id: 8364:chmp2a
uniprot id: Q6DFS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).

8364:abi1
gene id: 8364:abi1
uniprot id: A0A6I8QBF8
uniprot id: A0A6I8RZR8
uniprot id: A0A6I8SLM4
uniprot id: A0A8J0SG09
uniprot id: A0A8J0SG15
uniprot id: A0A8J0SQM5
uniprot id: A0A8J0SQT9
uniprot id: A0A8J0SQU4
uniprot id: F6QAY5
uniprot id: F6YNA4
uniprot id: Q68FB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: Belongs to the peptidase A22B family.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

8364:slc15a5
gene id: 8364:slc15a5
uniprot id: A0A8J1J8S0
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

8364:LOC105946710
gene id: 8364:LOC105946710
uniprot id: A0A8J0SG44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

8364:lsm3
gene id: 8364:lsm3
uniprot id: A9JSD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

8364:LOC100489129
gene id: 8364:LOC100489129
uniprot id: F6PX16
names: Similarity
messages: Belongs to the intermediate filament family.

8364:slain2l
gene id: 8364:slain2l
uniprot id: A0A6I8RRV9
uniprot id: B2GTY8
uniprot id: Q0VA20
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

8364:LOC116406816
gene id: 8364:LOC116406816
uniprot id: A0A8J1IPR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101734648
gene id: 8364:LOC101734648
uniprot id: A0A8J1IW12
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:egfr
gene id: 8364:egfr
uniprot id: F6UFM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

8364:LOC116411025
gene id: 8364:LOC116411025
uniprot id: A0A8J1JPV8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC101734961
gene id: 8364:LOC101734961
uniprot id: A0A8J1JTN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:maml1
gene id: 8364:maml1
uniprot id: A0A7D9NMC8
uniprot id: A0A8J0R239
uniprot id: F6YQ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PX domain-containing GAP family.
messages: Belongs to the mastermind family.
messages: Nucleus speckle

8364:exo1
gene id: 8364:exo1
uniprot id: F6RPI0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

8364:lipe
gene id: 8364:lipe
uniprot id: A0A6I8QE37
uniprot id: A0A6I8RJR0
uniprot id: A0A8J0SU12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipid droplet
messages: caveola
messages: cytosol

8364:LOC100497395
gene id: 8364:LOC100497395
uniprot id: A0A6I8S2U8
uniprot id: A0A8J0T4J5
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

8364:inpp5d
gene id: 8364:inpp5d
uniprot id: A0A803J691
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane

8364:LOC100495056
gene id: 8364:LOC100495056
uniprot id: A0A6I8S5R8
uniprot id: A0A8J1JLY6
uniprot id: A0A8J1JLZ0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:trappc2l
gene id: 8364:trappc2l
uniprot id: Q5M8X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: perinuclear region

8364:LOC100486950
gene id: 8364:LOC100486950
uniprot id: A0A8J0QRM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8364:itpkb
gene id: 8364:itpkb
uniprot id: A0A8J0QVE2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8364:gja10
gene id: 8364:gja10
uniprot id: A0A8J0T454
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:acer2
gene id: 8364:acer2
uniprot id: A0A8J0PJH3
uniprot id: F7B6Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

8364:rev3l
gene id: 8364:rev3l
uniprot id: A0A6I8QKS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

8364:kcnd1
gene id: 8364:kcnd1
uniprot id: A0A803K3P6
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

8364:wnt9a
gene id: 8364:wnt9a
uniprot id: A0A803JB93
uniprot id: A0A803K3R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:LOC101730588
gene id: 8364:LOC101730588
uniprot id: A0A8J0R2N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100492975
gene id: 8364:LOC100492975
uniprot id: A0A8J0QVW5
uniprot id: K9J7Q2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JARID1 histone demethylase family.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:dnmbp
gene id: 8364:dnmbp
uniprot id: A0A6I8Q517
uniprot id: A0A8J0R301
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack
messages: Synapse
messages: cytoskeleton

8364:atpsckmt
gene id: 8364:atpsckmt
uniprot id: A0A6I8RFB0
uniprot id: A0A8J0SN78
uniprot id: A0A8J0SR17
uniprot id: F6ZKB4
uniprot id: F7EG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane

8364:tff3.4
gene id: 8364:tff3.4
uniprot id: A0A8J0QWZ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:rrm1
gene id: 8364:rrm1
uniprot id: B1WAW9
uniprot id: F6TKJ2
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

8364:exoc2
gene id: 8364:exoc2
uniprot id: A0A6I8RRJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.
messages: Nucleus

8364:LOC100497034
gene id: 8364:LOC100497034
uniprot id: A0A6I8PUX7
uniprot id: A0A8J0QXU0
uniprot id: L7N3J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:LOC101735259
gene id: 8364:LOC101735259
uniprot id: A0A803JE74
uniprot id: A0A803K665
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAP10 family.
messages: Membrane

8364:patl2
gene id: 8364:patl2
uniprot id: B5DEB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAT1 family.
messages: Cytoplasm
messages: Interacts with ribonucleoprotein complex components. Interacts with cpeb (By similarity).
messages: Nucleus
messages: RNA-binding protein that acts as a translational repressor.

8364:virma
gene id: 8364:virma
uniprot id: A0A6I8SNH6
uniprot id: A0A8J0QPM6
names: Similarity
messages: Belongs to the vir family.

8364:grm5
gene id: 8364:grm5
uniprot id: A0A6I8Q821
uniprot id: A0A8J0SFY9
uniprot id: A0A8J0SH55
uniprot id: F6RSV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Belongs to the TMEM53 family.
messages: Cell membrane
messages: Membrane
messages: Nucleus outer membrane

8364:fgr
gene id: 8364:fgr
uniprot id: A0A6I8Q2T9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8364:cwf19l2
gene id: 8364:cwf19l2
uniprot id: F6R2H1
uniprot id: Q28C44
names: Similarity
messages: Belongs to the CWF19 family.

8364:LOC100489788
gene id: 8364:LOC100489788
uniprot id: A0A803JYA7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:tatdn3
gene id: 8364:tatdn3
uniprot id: A0A8J0SNL8
uniprot id: F6TI04
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

8364:LOC100490294
gene id: 8364:LOC100490294
uniprot id: A0A8J1IY73
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:dhrsx
gene id: 8364:dhrsx
uniprot id: A0A6I8QQN1
uniprot id: A0A8J0SYH1
uniprot id: A0A8J1J7C8
uniprot id: F6X3C1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:ssr2
gene id: 8364:ssr2
uniprot id: Q6DK88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

8364:LOC100490141
gene id: 8364:LOC100490141
uniprot id: A0A8J1IQJ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100493455
gene id: 8364:LOC100493455
uniprot id: A0A7D9N0M7
uniprot id: A0A8J1JDI9
names: Similarity
messages: Belongs to the lst-2 family.

8364:sephs1
gene id: 8364:sephs1
uniprot id: A0A8J1J758
uniprot id: Q6GL12
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class II subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Cell membrane
messages: Homodimer.
messages: Nucleus membrane
messages: Synthesizes selenophosphate from selenide and ATP.
messages: The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is probable, it is possible Cys-31 is the active site.

8364:tent5a
gene id: 8364:tent5a
uniprot id: A0A6I8RXX9
names: Similarity
messages: Belongs to the TENT family.

8364:zyx
gene id: 8364:zyx
uniprot id: Q0VA45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adhesion plaque protein. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Suppresses the transcription-repressing activity of hesx1/anf1 (By similarity).
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Interacts (via LIM2 domain) with hesx1/anf1.
messages: cytoskeleton
messages: focal adhesion

8364:LOC116406795
gene id: 8364:LOC116406795
uniprot id: A0A8J1ISV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:jag2
gene id: 8364:jag2
uniprot id: A0A6I8Q433
uniprot id: A0A6I8REQ8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8364:LOC116411776
gene id: 8364:LOC116411776
uniprot id: A0A8J1JRI4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:adh6
gene id: 8364:adh6
uniprot id: Q5I0S0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8364:LOC101730422
gene id: 8364:LOC101730422
uniprot id: A0A8J0R799
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:uso1
gene id: 8364:uso1
uniprot id: A0A6I8QCB2
uniprot id: A0A8J0QVL8
uniprot id: A0A8J0QZV0
uniprot id: A0A8J0R0P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

8364:pipox
gene id: 8364:pipox
uniprot id: B0BMN6
names: Similarity
messages: Belongs to the MSOX/MTOX family.

8364:vasp
gene id: 8364:vasp
uniprot id: Q66IM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

8364:naa20
gene id: 8364:naa20
uniprot id: Q6P632
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. ARD1 subfamily.
messages: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
messages: Component of the N-terminal acetyltransferase B (NatB) complex which is composed of naa20 and naa25.
messages: Cytoplasm
messages: Nucleus

8364:nfyb
gene id: 8364:nfyb
uniprot id: A0A6I8RVI7
uniprot id: A0A8J0T172
names: Function
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

8364:lacc1
gene id: 8364:lacc1
uniprot id: A0A8J1J8J4
uniprot id: F7CHT5
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

8364:stau2
gene id: 8364:stau2
uniprot id: F6YKW3
uniprot id: Q5M7M7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: RNA-binding protein required for the microtubule-dependent transport of RNAs within polarized cell types.
messages: The DRBM 3 domain appears to be the major RNA-binding determinant.

8364:mthfd1
gene id: 8364:mthfd1
uniprot id: Q66JJ9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

8364:crmp1
gene id: 8364:crmp1
uniprot id: A0A8J0SNS0
uniprot id: A0A8J0SRL5
uniprot id: Q0V9W2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

8364:LOC100498072
gene id: 8364:LOC100498072
uniprot id: A0A6I8QAK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:nek6
gene id: 8364:nek6
uniprot id: Q6DIX9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:wi2-2373i1.2
gene id: 8364:wi2-2373i1.2
uniprot id: A0A803JBW0
names: Subcellular Location Annotation
messages: Nucleus

8364:gng10
gene id: 8364:gng10
uniprot id: A0A6I8RCH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:ctc1
gene id: 8364:ctc1
uniprot id: A0A8J1J6N4
uniprot id: A0A8J1J933
uniprot id: B2GUF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

8364:svep1l
gene id: 8364:svep1l
uniprot id: F6WI33
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:acat2
gene id: 8364:acat2
uniprot id: Q6P802
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

8364:map7d2
gene id: 8364:map7d2
uniprot id: A0A803JJY7
uniprot id: A0A8J0S831
uniprot id: A0A8J0SD99
uniprot id: A0A8J0SF61
uniprot id: A0A8J0SG74
uniprot id: A0A8J1J2D9
uniprot id: A0A8J1J5T4
uniprot id: F6YKE8
uniprot id: Q08CX9
names: Similarity
messages: Belongs to the MAP7 family.

8364:LOC100486975
gene id: 8364:LOC100486975
uniprot id: A0A8J0QVX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ca8
gene id: 8364:ca8
uniprot id: F7A3U7
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

8364:nkx2-2
gene id: 8364:nkx2-2
uniprot id: A0A8J0R1U3
uniprot id: F6Y5I3
uniprot id: F7E3E4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane
messages: Nucleus

8364:star
gene id: 8364:star
uniprot id: A0A6I8Q7U2
uniprot id: F6X7I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
messages: cytoskeleton

8364:acot2
gene id: 8364:acot2
uniprot id: B0BM61
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8364:tnrc6c
gene id: 8364:tnrc6c
uniprot id: A0A6I8Q493
uniprot id: A0A6I8RY94
names: Similarity
messages: Belongs to the GW182 family.

8364:ndufa7
gene id: 8364:ndufa7
uniprot id: A0A6I8R0S0
uniprot id: A0A8J0QZR1
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

8364:oplah
gene id: 8364:oplah
uniprot id: A0JM10
uniprot id: F6WQY5
names: Similarity
messages: Belongs to the oxoprolinase family.

8364:irf5
gene id: 8364:irf5
uniprot id: A0A8J0S9Q8
uniprot id: F7EJG5
uniprot id: Q28C53
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:LOC100493456
gene id: 8364:LOC100493456
uniprot id: A0A8J0QTL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

8364:dnaja2
gene id: 8364:dnaja2
uniprot id: A0A803KJR3
uniprot id: F6UGS5
names: Subcellular Location Annotation
messages: Membrane

8364:elmo1
gene id: 8364:elmo1
uniprot id: A0A6I8RDI5
uniprot id: A0A6I8S2T7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

8364:mrpl40
gene id: 8364:mrpl40
uniprot id: A4IHC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

8364:LOC116412112
gene id: 8364:LOC116412112
uniprot id: A0A8J1JYC4
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:mc3r
gene id: 8364:mc3r
uniprot id: A0A803J8I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

8364:polr2c
gene id: 8364:polr2c
uniprot id: Q6P7Y7
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

8364:cavin4
gene id: 8364:cavin4
uniprot id: A0A8J0QMP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

8364:add2
gene id: 8364:add2
uniprot id: A4IIR0
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

8364:gpr12
gene id: 8364:gpr12
uniprot id: A0A803KDV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dcaf8
gene id: 8364:dcaf8
uniprot id: Q28I90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF8 family.
messages: Cytoplasm
messages: Nucleus

8364:LOC116407584
gene id: 8364:LOC116407584
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:ocel1
gene id: 8364:ocel1
uniprot id: A0A8J0SYG4
uniprot id: A0A8J0SYJ6
uniprot id: A0A8J0SZR4
uniprot id: A9JTT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8364:spdyc
gene id: 8364:spdyc
uniprot id: A0A8J1JF34
uniprot id: F7C4W0
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8364:LOC100125044
gene id: 8364:LOC100125044
uniprot id: A4IIR3
names: Similarity
messages: Belongs to the SCAR/WAVE family.

8364:LOC100487510
gene id: 8364:LOC100487510
uniprot id: A0A8J0SWP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:adgra3
gene id: 8364:adgra3
uniprot id: A0A6I8QJT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8364:serpine2
gene id: 8364:serpine2
uniprot id: Q28C25
names: Similarity
messages: Belongs to the serpin family.

8364:tle5
gene id: 8364:tle5
uniprot id: A4IIB2
uniprot id: Q28C95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

8364:smim12
gene id: 8364:smim12
uniprot id: Q28EM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM12 family.
messages: Membrane

8364:tdp1
gene id: 8364:tdp1
uniprot id: A0A8J1ILM2
uniprot id: A0A8J1IPF0
uniprot id: Q28BM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

8364:LOC100494394
gene id: 8364:LOC100494394
uniprot id: F7ELZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tbxa2r
gene id: 8364:tbxa2r
uniprot id: F7CRB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC116408622
gene id: 8364:LOC116408622
uniprot id: A0A8J1J2Q3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100492690
gene id: 8364:LOC100492690
uniprot id: A0A6I8QMY2
uniprot id: F6XTC6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101731580
gene id: 8364:LOC101731580
uniprot id: A0A8J1IX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8364:cdk2
gene id: 8364:cdk2
uniprot id: A0A803KKC6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:cldn6.1
gene id: 8364:cldn6.1
uniprot id: Q6PBE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:LOC116411994
gene id: 8364:LOC116411994
uniprot id: A0A8J1JUF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:prf1
gene id: 8364:prf1
uniprot id: A0A8J1IXY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8364:atp1a3
gene id: 8364:atp1a3
uniprot id: B1H2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8364:sox7
gene id: 8364:sox7
uniprot id: Q28GD5
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the embryonic pronephric sinus as well as posterior cardinal veins.
messages: Nucleus
messages: Transcription factor. Binds to the DNA sequence 5'-AACAAT-3'. Acts downstream of vegt and upstream of nodal signaling to promote endodermal and mesodermal differentiation by promoting vegt-induced expression of both endodermal genes (including endodermin) and mesodermal genes (including snai1/snail and snai2/slug). Induces expression of multiple nodal genes (including nodal, nodal2, nodal4, nodal5 and nodal6) and binds directly to sites within the promoter of the nodal5 gene. The endodermal and mesodermal specification pathways then interact to initiate cardiogenesis. Acts partially redundantly with sox18 during cardiogenesis. Also acts as an antagonist of beta-catenin signaling (By similarity). Regulates (possibly indirectly) development of the pronephros, the functional larval kidney.

8364:mrpl10
gene id: 8364:mrpl10
uniprot id: A0A8J1IXC0
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

8364:ctss.2
gene id: 8364:ctss.2
uniprot id: Q5M8Z4
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:mrpl43
gene id: 8364:mrpl43
uniprot id: Q28J57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

8364:dgat1
gene id: 8364:dgat1
uniprot id: A0A803JY67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

8364:gdap2
gene id: 8364:gdap2
uniprot id: A0A8J1J1R8
uniprot id: Q5CZL1
names: Similarity
messages: Belongs to the GDAP2 family.

8364:tpst2
gene id: 8364:tpst2
uniprot id: A0A8J0PJA9
uniprot id: F6ULQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

8364:uba6
gene id: 8364:uba6
uniprot id: A0A6I8Q9E6
uniprot id: A0A8J0QP73
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

8364:galntl6
gene id: 8364:galntl6
uniprot id: F7AN95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:eif6
gene id: 8364:eif6
uniprot id: Q6DDC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: nucleolus

8364:rnf114
gene id: 8364:rnf114
uniprot id: Q6IZ49
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

8364:uqcrq
gene id: 8364:uqcrq
uniprot id: B7ZT93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

8364:snrpd1
gene id: 8364:snrpd1
uniprot id: Q6GLH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

8364:galnt16
gene id: 8364:galnt16
uniprot id: Q28CC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:tm4sf19
gene id: 8364:tm4sf19
uniprot id: A0A6I8Q2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:LOC101732542
gene id: 8364:LOC101732542
uniprot id: A0A8J1JEU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

8364:amd1
gene id: 8364:amd1
uniprot id: A0A6I8Q5Y2
uniprot id: B1H2L2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.

8364:ankrd34a
gene id: 8364:ankrd34a
uniprot id: F7BFH4
names: Similarity
messages: Belongs to the ANKRD34 family.

8364:enoph1
gene id: 8364:enoph1
uniprot id: A0A8J0SQ98
uniprot id: A0A8J1JGR0
uniprot id: Q28C69
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Nucleus

8364:epb41l5
gene id: 8364:epb41l5
uniprot id: A0A803K553
uniprot id: A0A8J1IUX4
uniprot id: Q28IK3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.

8364:gdpd3
gene id: 8364:gdpd3
uniprot id: A4IGW3
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8364:lztfl1
gene id: 8364:lztfl1
uniprot id: A9ULJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

8364:ruvbl1
gene id: 8364:ruvbl1
uniprot id: F6Q5T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

8364:alg5
gene id: 8364:alg5
uniprot id: Q6DIF5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

8364:sec24d
gene id: 8364:sec24d
uniprot id: A0A7D9NJM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8364:avil
gene id: 8364:avil
uniprot id: A0A7D9NKF1
names: Similarity
messages: Belongs to the villin/gelsolin family.

8364:rcan1
gene id: 8364:rcan1
uniprot id: Q28HQ3
uniprot id: Q6DK90
names: Similarity
messages: Belongs to the RCAN family.

8364:shcbp1
gene id: 8364:shcbp1
uniprot id: A0A8J0SIW4
uniprot id: Q0P4V3
names: Subcellular Location Annotation
messages: spindle

8364:lgals3
gene id: 8364:lgals3
uniprot id: Q6P8B0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

8364:acvr1
gene id: 8364:acvr1
uniprot id: Q28E06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8364:htr2b
gene id: 8364:htr2b
uniprot id: A0A7D9NMF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

8364:cs
gene id: 8364:cs
uniprot id: Q28DK1
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homodimer.
messages: Mitochondrion matrix

8364:LOC101731784
gene id: 8364:LOC101731784
uniprot id: A0A8J1JF29
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:lhfpl2
gene id: 8364:lhfpl2
uniprot id: A0A803JRQ1
names: Subcellular Location Annotation
messages: Membrane

8364:trmt44
gene id: 8364:trmt44
uniprot id: A0A6I8PM29
uniprot id: A0A8J0S6N9
uniprot id: A0A8J1J2B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
messages: Belongs to the TRM44 family.
messages: Cytoplasm
messages: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

8364:fignl1
gene id: 8364:fignl1
uniprot id: A4IHT0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Hexamer.
messages: May be involved in DNA double-strand break (DBS) repair via homologous recombination (HR). May regulate osteoblast proliferation and differentiation (By similarity).
messages: Nucleus
messages: The N-terminus is necessary for its recruitment to DNA damage sites.
messages: perinuclear region

8364:klf7
gene id: 8364:klf7
uniprot id: F6QA23
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:slc4a8
gene id: 8364:slc4a8
uniprot id: F6QPK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

8364:LOC101731425
gene id: 8364:LOC101731425
uniprot id: A0A803JIT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

8364:LOC100486700
gene id: 8364:LOC100486700
uniprot id: A0A1B8Y8T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:prkar1a
gene id: 8364:prkar1a
uniprot id: Q5BL84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

8364:btc
gene id: 8364:btc
uniprot id: A0A8J0S681
uniprot id: F7CD16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116410384
gene id: 8364:LOC116410384
uniprot id: A0A8J1JFF8
names: Subcellular Location Annotation
messages: Nucleus

8364:synm
gene id: 8364:synm
uniprot id: A0A6I8SEV3
names: Similarity
messages: Belongs to the intermediate filament family.

8364:LOC101732858
gene id: 8364:LOC101732858
uniprot id: A0A8J1IVX3
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

8364:aktip
gene id: 8364:aktip
uniprot id: Q28IA3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.
messages: May function to promote vesicle trafficking and/or fusion. May also regulate apoptosis (By similarity).

8364:LOC116411633
gene id: 8364:LOC116411633
uniprot id: F6XTM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:pdzk1ip1
gene id: 8364:pdzk1ip1
uniprot id: A0A8J1JG06
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100485636
gene id: 8364:LOC100485636
uniprot id: F6ZGF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

8364:ebag9
gene id: 8364:ebag9
uniprot id: Q28GF1
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

8364:c15orf41
gene id: 8364:c15orf41
uniprot id: Q28HL3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May play a role in erythroid cell differentiation.
messages: Nucleus

8364:npc1
gene id: 8364:npc1
uniprot id: A0A6I8R5B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

8364:LOC116406456
gene id: 8364:LOC116406456
uniprot id: A0A8J0QRJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8364:tlcd3a
gene id: 8364:tlcd3a
uniprot id: F6ZFA7
names: Subcellular Location Annotation
messages: Membrane

8364:map7d1
gene id: 8364:map7d1
uniprot id: A0A8J1J4F2
uniprot id: F7CXB2
names: Similarity
messages: Belongs to the MAP7 family.

8364:auh
gene id: 8364:auh
uniprot id: B2GUS5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8364:adora3.2
gene id: 8364:adora3.2
uniprot id: F7A0F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

8364:ube2h
gene id: 8364:ube2h
uniprot id: Q6DJ44
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:pigy
gene id: 8364:pigy
uniprot id: P0C1P1
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Component of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2.
messages: Endoplasmic reticulum membrane
messages: PREY is derived from the same bicistronic transcript that encodes these 2 different proteins.
messages: Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the catalytic subunit PIGA.

8364:LOC116409603
gene id: 8364:LOC116409603
uniprot id: A0A8J1J8J7
names: Subcellular Location Annotation
messages: Membrane

8364:nprl3
gene id: 8364:nprl3
uniprot id: A0A6I8SSI7
uniprot id: A4IHF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

8364:scarb1
gene id: 8364:scarb1
uniprot id: A0A803JWS2
uniprot id: F6U1H4
names: Similarity
messages: Belongs to the CD36 family.

8364:LOC105947904
gene id: 8364:LOC105947904
uniprot id: A0A8J0SRN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rpl13
gene id: 8364:rpl13
uniprot id: Q6P639
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

8364:ppp1cc
gene id: 8364:ppp1cc
uniprot id: Q6NVU2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cleavage furrow
messages: Cytoplasm
messages: Midbody
messages: Mitochondrion
messages: Nucleus
messages: Nucleus speckle
messages: PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits.
messages: Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin (By similarity).
messages: kinetochore
messages: microtubule organizing center
messages: nucleolus
messages: nucleoplasm

8364:washc1
gene id: 8364:washc1
uniprot id: Q28DN4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
messages: Belongs to the WASH1 family.
messages: Component of the WASH complex.
messages: Early endosome membrane
messages: Recycling endosome membrane
messages: The VCA (verprolin, cofilin, acidic) domain promotes actin polymerization by the Arp2/3 complex in vitro.

8364:aqp12a
gene id: 8364:aqp12a
uniprot id: A0A6I8PVB6
uniprot id: A0A8J0QKI1
uniprot id: A0A8J1JLR3
names: Subcellular Location Annotation
messages: Membrane

8364:heatr5a
gene id: 8364:heatr5a
uniprot id: A0A6I8QC90
uniprot id: A0JP94
names: Similarity
messages: Belongs to the HEATR5 family.

8364:nnmt
gene id: 8364:nnmt
uniprot id: A0A8J0QZ81
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:snx4
gene id: 8364:snx4
uniprot id: A0A8J1ITV6
names: Similarity
messages: Belongs to the sorting nexin family.

8364:LOC101734698
gene id: 8364:LOC101734698
uniprot id: A0A6I8SER6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ezh2
gene id: 8364:ezh2
uniprot id: A0A6I8S7L9
uniprot id: A0A6I8SN85
uniprot id: A0A8J0SR10
uniprot id: F6SQP1
uniprot id: Q28D84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
messages: Component of the prc2/eed-ezh2 complex.
messages: Nucleus
messages: Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes.

8364:aldh1l2
gene id: 8364:aldh1l2
uniprot id: F6WMV5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

8364:LOC101730357
gene id: 8364:LOC101730357
uniprot id: A0A8J1JQI0
names: Similarity
messages: Belongs to the apolipoprotein L family.

8364:ndst2
gene id: 8364:ndst2
uniprot id: F6Z353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

8364:ddx31
gene id: 8364:ddx31
uniprot id: A0A803JJP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:zwilch
gene id: 8364:zwilch
uniprot id: Q0IJ01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex composed of kntc1/rod, zw10 and zwilch.
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mad1-mad2 complexes onto kinetochores (By similarity).
messages: kinetochore

8364:mc2r
gene id: 8364:mc2r
uniprot id: A0A8J0QQZ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

8364:prkrip1
gene id: 8364:prkrip1
uniprot id: B1WB20
uniprot id: Q28IN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRKRIP1 family.
messages: Component of the pre-catalytic and post-catalytic spliceosome complexes.
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA (By similarity).
messages: nucleolus

8364:nkiras1
gene id: 8364:nkiras1
uniprot id: A0A803JEN5
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

8364:tmem234
gene id: 8364:tmem234
uniprot id: A0A6I8S7V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

8364:LOC116412095
gene id: 8364:LOC116412095
uniprot id: A0A8J1JUA6
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:syngr2
gene id: 8364:syngr2
uniprot id: Q6DIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

8364:cdc45
gene id: 8364:cdc45
uniprot id: A0A8J0QIR0
uniprot id: F6TDA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

8364:sox17a
gene id: 8364:sox17a
uniprot id: Q8AWH3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed throughout the deep and superficial endoderm during gastrulation. During neural and early tail bud stages, expression declines significantly in the anterior endoderm, except in the endoderm behind the cement gland. Strong expression persists in the endoderm posterior to the liver diverticulum until late tail bud stage. By late tailbud, expression is undetectable in most of the endoderm but is maintained in the presumptive gall bladder region and the extreme posterior region. In addition, expressed in endothelial cells in the head and along the flank of the embryo.
messages: Interacts (via C-terminus) with ctnnb1/beta-catenin (via Armadillo repeats); this interaction is required for inhibition of wnt-signaling.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription activator. Binds to the DNA sequence 5'-AACAAT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling (By similarity).

8364:pola2
gene id: 8364:pola2
uniprot id: Q6DEY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

8364:LOC100495877
gene id: 8364:LOC100495877
uniprot id: A0A8J0QVF5
names: Subcellular Location Annotation
messages: Membrane

8364:sox18
gene id: 8364:sox18
uniprot id: B3DLD3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Binds target DNA via the HMG box domain.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor. Binds to the consensus DNA sequence 5'-AACAAT-3'. Also binds 5'-CACAAT-3' and 5'-AATAAT-3' but with a lower affinity. Acts partially redundantly with sox7 during cardiogenesis, acting indirectly through nodal-signaling to induce mesodermal, organizer and endodermal tissues, which then interact to initiate cardiogenesis. Also acts as an antagonist of beta-catenin signaling (By similarity).

8364:utp25
gene id: 8364:utp25
uniprot id: Q642T7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP25 family.
messages: Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (By similarity). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (By similarity).
messages: Interacts with CAPN3; the interaction is required for CAPN3 translocation to the nucleolus.
messages: Phosphorylated. Phosphorylation is required to promote p53/TP53 degradation in the nucleolus which promotes cell cycle progression and liver development.
messages: nucleolus

8364:c4orf48
gene id: 8364:c4orf48
uniprot id: A0A6I8R8M3
uniprot id: A0A803J543
names: Subcellular Location Annotation
messages: Secreted

8364:ffar2
gene id: 8364:ffar2
uniprot id: A0A1B8Y6Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:syncrip
gene id: 8364:syncrip
uniprot id: F7BRP1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:xpo5
gene id: 8364:xpo5
uniprot id: A0A8J1JHW3
uniprot id: A1L1C9
names: Subcellular Location Annotation
messages: Cytoplasm

8364:tnfrsf4
gene id: 8364:tnfrsf4
uniprot id: A0A6I8RH35
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:klhdc10
gene id: 8364:klhdc10
uniprot id: Q28DE7
names: Function
names: Subunit
messages: Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter KLHDC10.
messages: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) at the C-terminus, leading to their ubiquitination and degradation. Participates in the oxidative stress-induced cell death through MAP3K5 activation.

8364:slc35d2
gene id: 8364:slc35d2
uniprot id: A0A6I8T280
names: Subcellular Location Annotation
messages: Membrane

8364:acod1la
gene id: 8364:acod1la
uniprot id: A0A6I8Q718
names: Similarity
messages: Belongs to the PrpD family.

8364:crygdl.17
gene id: 8364:crygdl.17
uniprot id: A0A8J0SAF9
uniprot id: A0A8J0SD70
uniprot id: A0A8J1JUC7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:nop14
gene id: 8364:nop14
uniprot id: F7DV09
uniprot id: L7N3G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

8364:cyp2a6.4
gene id: 8364:cyp2a6.4
uniprot id: A0A8J0R446
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:rxrb
gene id: 8364:rxrb
uniprot id: A0A8J0SUM8
uniprot id: B3DLT9
uniprot id: F7DF86
uniprot id: Q28CI3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

8364:lrtomt
gene id: 8364:lrtomt
uniprot id: A0A803KJM8
uniprot id: Q6P899
names: Subcellular Location Annotation
messages: Cytoplasm

8364:sft2d1
gene id: 8364:sft2d1
uniprot id: A0A6I8Q0A3
uniprot id: A0A8J0PDF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

8364:fcf1
gene id: 8364:fcf1
uniprot id: Q6DIE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

8364:gins1
gene id: 8364:gins1
uniprot id: B5DES7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

8364:LOC101732693
gene id: 8364:LOC101732693
uniprot id: F6XZ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:serinc2
gene id: 8364:serinc2
uniprot id: A0A6I8QTV6
uniprot id: Q28HX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

8364:aspn
gene id: 8364:aspn
uniprot id: F7AM25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

8364:LOC100216173
gene id: 8364:LOC100216173
uniprot id: A0A803J8F8
uniprot id: B5DDW9
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

8364:mtbp
gene id: 8364:mtbp
uniprot id: Q0P4G8
names: Function
names: Similarity
messages: Belongs to the MTBP family.
messages: May play a role in mdm2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of mdm2, thereby enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of p53/TP53 and its subsequent degradation (By similarity).

8364:apex2
gene id: 8364:apex2
uniprot id: A0A8J1INW5
uniprot id: Q6DFQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

8364:cxcr4
gene id: 8364:cxcr4
uniprot id: Q07FZ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome
messages: Late endosome
messages: Lysosome
messages: Monomer. Can form dimers (By similarity).
messages: Nucleus
messages: O- and N-glycosylated.
messages: Receptor for the C-X-C chemokine cxcl12/sdf-1. Transduces a signal by increasing the intracellular calcium ion level. Signaling with cxcl12/sdf-1 mediates the directional movement of mesodermal cells during gastrulation. May play a role in the migration of embryonic presumptive primordial germ cells (pPGCs). May also be involved in regulating migration of hematopoietic stem cells into the larval liver (By similarity).
messages: Sulfation is required for efficient binding of cxcl12/sdf-1alpha and promotes its dimerization.

8364:dusp6
gene id: 8364:dusp6
uniprot id: Q28E94
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8364:ola1
gene id: 8364:ola1
uniprot id: Q66JG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

8364:foxb2
gene id: 8364:foxb2
uniprot id: A0A803JDI5
names: Subcellular Location Annotation
messages: Nucleus

8364:tmem53
gene id: 8364:tmem53
uniprot id: A9JSB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

8364:fgf7
gene id: 8364:fgf7
uniprot id: Q5M7N7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8364:LOC116408368
gene id: 8364:LOC116408368
uniprot id: A0A8J1J2R8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:wdr1
gene id: 8364:wdr1
uniprot id: Q6DIF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat AIP1 family.
messages: Cell membrane
messages: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Doesn't sever actin filaments alone, but caps the barbed ends of filaments severed by cofilin, which blocks annealing and depolymerization and allows more extensive severing by cofilin (By similarity).
messages: Nucleus
messages: cytoskeleton

8364:LOC779885
gene id: 8364:LOC779885
uniprot id: Q0IIS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8364:snd1
gene id: 8364:snd1
uniprot id: A0A8J0QJN4
uniprot id: Q6P4X4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

8364:acyp1
gene id: 8364:acyp1
uniprot id: B7ZSP5
uniprot id: Q28FK7
names: Similarity
messages: Belongs to the acylphosphatase family.

8364:vwc2l
gene id: 8364:vwc2l
uniprot id: A0A6I8RFM2
uniprot id: A0A8J0T430
names: Subcellular Location Annotation
messages: Synapse

8364:dgkb
gene id: 8364:dgkb
uniprot id: A4III1
uniprot id: F6X173
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8364:stxbp5l
gene id: 8364:stxbp5l
uniprot id: A0A6I8QXN9
uniprot id: A0A6I8R8H1
uniprot id: A0A6I8R8S0
uniprot id: A0A6I8RL54
uniprot id: A0A6I8SC58
uniprot id: A0A8J0QX26
uniprot id: A0A8J0QZ66
uniprot id: A0A8J0R1A9
uniprot id: A0A8J1J369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8364:LOC108644486
gene id: 8364:LOC108644486
uniprot id: A0A8J1IPL0
names: Similarity
messages: Belongs to the MHC class I family.

8364:capsl
gene id: 8364:capsl
uniprot id: F6UVQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8364:samd8
gene id: 8364:samd8
uniprot id: A0A6I8RF67
uniprot id: Q28CJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

8364:LOC100127794
gene id: 8364:LOC100127794
uniprot id: A0A8J1J6F9
uniprot id: A0A8J1J8V7
uniprot id: A9JTM4
names: Subcellular Location Annotation
messages: Membrane

8364:evl
gene id: 8364:evl
uniprot id: A0A6I8REJ7
uniprot id: A0A6I8SB88
uniprot id: A0A8J0SJY1
uniprot id: A0A8J0SJY6
uniprot id: A0A8J0SS47
uniprot id: A0A8J0STS2
uniprot id: A0A8J0SUM3
uniprot id: A0A8J0SV51
uniprot id: A4IH41
uniprot id: F6RBK4
uniprot id: F6VSA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane
messages: cytoskeleton
messages: lamellipodium
messages: stress fiber

8364:LOC116412178
gene id: 8364:LOC116412178
uniprot id: A0A8J1JUW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100490910
gene id: 8364:LOC100490910
uniprot id: A0A8J1J3F5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:fam114a1
gene id: 8364:fam114a1
uniprot id: A0A6I8S9V6
uniprot id: A0A8J0SAD0
names: Similarity
messages: Belongs to the FAM114 family.

8364:rassf3
gene id: 8364:rassf3
uniprot id: A0A6I8RJP6
names: Subcellular Location Annotation
messages: cytoskeleton

8364:cd99
gene id: 8364:cd99
uniprot id: A0A6I8QVQ9
uniprot id: A0A6I8SM91
uniprot id: A0A803JM26
uniprot id: A0A8J0S8C7
names: Similarity
messages: Belongs to the CD99 family.

8364:ror1
gene id: 8364:ror1
uniprot id: A0A6I8QGM9
uniprot id: A0A6I8RQP3
uniprot id: A0A6I8SZJ2
uniprot id: G1K3J5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:scn8a
gene id: 8364:scn8a
uniprot id: A0A8J0QFV1
uniprot id: A0A8J1J1X9
uniprot id: A0A8J1J4B2
uniprot id: A0A8J1J5A4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8364:LOC100487906
gene id: 8364:LOC100487906
uniprot id: F6YU25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8364:pcmtd1
gene id: 8364:pcmtd1
uniprot id: Q5M7M8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

8364:donson
gene id: 8364:donson
uniprot id: Q6P1U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DONSON family.
messages: Component of the replisome complex.
messages: Nucleus
messages: Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.

8364:vps29
gene id: 8364:vps29
uniprot id: A0A6I8PY61
uniprot id: Q6DEU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) (By similarity). Acts also as component of the retriever complex. The retriever complex is an heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrins. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity).
messages: Belongs to the VPS29 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants (By similarity). Component of the heterotrimeric retriever complex (By similarity).
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

8364:krt17
gene id: 8364:krt17
uniprot id: F7AZ24
names: Similarity
messages: Belongs to the intermediate filament family.

8364:ddx5
gene id: 8364:ddx5
uniprot id: Q6P4W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: Cytoplasm
messages: Nucleus

8364:tex261
gene id: 8364:tex261
uniprot id: A9JSB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

8364:ccdc90b
gene id: 8364:ccdc90b
uniprot id: Q6DJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC90 family.
messages: Mitochondrion membrane

8364:abcc2
gene id: 8364:abcc2
uniprot id: A0A6I8S1Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

8364:LOC100494858
gene id: 8364:LOC100494858
uniprot id: A0A803JA95
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:ptges2
gene id: 8364:ptges2
uniprot id: F7BQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

8364:fam50a
gene id: 8364:fam50a
uniprot id: Q28BK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM50 family.
messages: Nucleus
messages: Probably involved in the regulation of pre-mRNA splicing.

8364:rflna
gene id: 8364:rflna
uniprot id: Q640A9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

8364:slc25a15.2
gene id: 8364:slc25a15.2
uniprot id: A0A803KJG6
uniprot id: F7DBW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:gpr182
gene id: 8364:gpr182
uniprot id: A0A803J537
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:cdk5
gene id: 8364:cdk5
uniprot id: Q0VFL9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:c2orf76
gene id: 8364:c2orf76
uniprot id: A0A8J1IRQ4
uniprot id: A0A8J1IRR7
uniprot id: A4IGN3
names: Similarity
messages: Belongs to the UPF0538 family.

8364:chrna2
gene id: 8364:chrna2
uniprot id: A0A6I8T284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:LOC116412171
gene id: 8364:LOC116412171
uniprot id: A0A8J1JXA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:pigw
gene id: 8364:pigw
uniprot id: F6QUR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

8364:traf4
gene id: 8364:traf4
uniprot id: Q6DEV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8364:LOC100492872
gene id: 8364:LOC100492872
uniprot id: A0A1B8XSL0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:uxt
gene id: 8364:uxt
uniprot id: A0A803K2Y1
names: Similarity
messages: Belongs to the UXT family.

8364:osbp2
gene id: 8364:osbp2
uniprot id: A0A8J0QKZ2
uniprot id: A0A8J0SLC4
uniprot id: A0A8J0SW12
names: Similarity
messages: Belongs to the OSBP family.

8364:casc3
gene id: 8364:casc3
uniprot id: A0A6I8S658
uniprot id: A0A6I8S9U9
uniprot id: Q5CZI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Cytoplasmic ribonucleoprotein granule
messages: Identified in the spliceosome C complex. Component of the mRNA splicing-dependent exon junction complex (EJC), which contains at least casc3, eif4a3, magoh, nxf1 and rbm8a (By similarity). Forms homooligomers (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions.
messages: Stress granule
messages: dendrite
messages: perinuclear region

8364:tm2d2
gene id: 8364:tm2d2
uniprot id: Q5M8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

8364:gdf2
gene id: 8364:gdf2
uniprot id: A0A6I8R6N3
uniprot id: A0A8J0R5U3
names: Similarity
messages: Belongs to the TGF-beta family.

8364:ppp1r14a
gene id: 8364:ppp1r14a
uniprot id: Q66KC0
names: Similarity
messages: Belongs to the PP1 inhibitor family.

8364:gnrhr2
gene id: 8364:gnrhr2
uniprot id: F6XX21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105946363
gene id: 8364:LOC105946363
uniprot id: A0A8J0S6S9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:chsy1
gene id: 8364:chsy1
uniprot id: F7BVZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

8364:map7
gene id: 8364:map7
uniprot id: A0A6I8QS57
uniprot id: A0A6I8SNW5
uniprot id: A0A8J0QLY7
uniprot id: A0A8J0R4V5
uniprot id: A0A8J0SEZ7
uniprot id: A0A8J1JJG0
uniprot id: A0A8J1JJG4
names: Similarity
messages: Belongs to the MAP7 family.

8364:LOC116408348
gene id: 8364:LOC116408348
uniprot id: A0A8J1IZF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

8364:LOC100487580
gene id: 8364:LOC100487580
uniprot id: A0A8J1JX60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:ppp1r9b
gene id: 8364:ppp1r9b
uniprot id: A0A6I8RQQ3
names: Subcellular Location Annotation
messages: cytoskeleton

8364:LOC108648863
gene id: 8364:LOC108648863
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:atg16l1
gene id: 8364:atg16l1
uniprot id: Q5I0B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ATG16 family.
messages: Cytoplasm
messages: Homooligomer. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa).
messages: Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
messages: Preautophagosomal structure membrane

8364:pheta2
gene id: 8364:pheta2
uniprot id: F6U7G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

8364:xpnpep1
gene id: 8364:xpnpep1
uniprot id: A0A8J1JUH4
uniprot id: A0A8J1JVT4
uniprot id: B1WBJ7
names: Similarity
messages: Belongs to the peptidase M24B family.

8364:ltk
gene id: 8364:ltk
uniprot id: F6UBP5
names: Caution
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:myoz3
gene id: 8364:myoz3
uniprot id: Q5M8K5
names: Similarity
messages: Belongs to the myozenin family.

8364:LOC100490900
gene id: 8364:LOC100490900
uniprot id: A0A8J0SAL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:fam20c
gene id: 8364:fam20c
uniprot id: A0A6I8T269
names: Similarity
messages: Belongs to the FAM20 family.

8364:snx5
gene id: 8364:snx5
uniprot id: A0A6I8QE32
uniprot id: A0A8J1JI66
uniprot id: Q28F22
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

8364:casq1
gene id: 8364:casq1
uniprot id: Q6PBF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

8364:mrpl54
gene id: 8364:mrpl54
uniprot id: A0A6I8PUR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

8364:slc39a5
gene id: 8364:slc39a5
uniprot id: A0A8J0SER4
uniprot id: B1H196
names: Subcellular Location Annotation
messages: Membrane

8364:nol10
gene id: 8364:nol10
uniprot id: Q6NVM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

8364:LOC100487426
gene id: 8364:LOC100487426
uniprot id: A0A803K9H1
uniprot id: A0A8J1JVG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:ogt
gene id: 8364:ogt
uniprot id: A0A6I8QVG7
uniprot id: A0A8J0SVQ3
uniprot id: Q5BL53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

8364:mga
gene id: 8364:mga
uniprot id: A0A803K913
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:mdh1b
gene id: 8364:mdh1b
uniprot id: A0A6I8PWZ6
uniprot id: A0A8J1IT12
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

8364:LOC116407705
gene id: 8364:LOC116407705
uniprot id: A0A8J1IY50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

8364:slc17a5
gene id: 8364:slc17a5
uniprot id: Q0V9A2
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100495184
gene id: 8364:LOC100495184
uniprot id: B5DDY3
uniprot id: Q28DR4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8364:st6gal1
gene id: 8364:st6gal1
uniprot id: A0A6I8RQD2
uniprot id: E4ZFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:LOC101731865
gene id: 8364:LOC101731865
uniprot id: A0A8J0STC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8364:rorb
gene id: 8364:rorb
uniprot id: A0A6I8RCU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8364:fcer1g
gene id: 8364:fcer1g
uniprot id: A0A803J6T2
uniprot id: A0A8J1IQL5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:greb1
gene id: 8364:greb1
uniprot id: A0A6I8R968
uniprot id: F7D1Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

8364:stra6
gene id: 8364:stra6
uniprot id: F6W823
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105946313
gene id: 8364:LOC105946313
uniprot id: A0A8J0SDX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC779564
gene id: 8364:LOC779564
uniprot id: F6XBZ7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8364:LOC100491166
gene id: 8364:LOC100491166
uniprot id: A0A803JRH6
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8364:get1
gene id: 8364:get1
uniprot id: Q6DD99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:wdr4
gene id: 8364:wdr4
uniprot id: A0A8J1J6G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit METTL1.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

8364:prxl2b
gene id: 8364:prxl2b
uniprot id: Q28IJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily.
messages: Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity).
messages: cytosol

8364:LOC101733980
gene id: 8364:LOC101733980
uniprot id: A0A8J0R1P7
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:ebpl
gene id: 8364:ebpl
uniprot id: F6ZQF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:uqcc1
gene id: 8364:uqcc1
uniprot id: Q6P2X1
names: Similarity
messages: Belongs to the CBP3 family.

8364:kcnq1
gene id: 8364:kcnq1
uniprot id: A0A6I8S7B1
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft

8364:LOC100497132
gene id: 8364:LOC100497132
uniprot id: A0A8J0R1Q6
names: Subcellular Location Annotation
messages: Membrane

8364:golph3
gene id: 8364:golph3
uniprot id: Q28C84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

8364:en1
gene id: 8364:en1
uniprot id: A0A803JJF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

8364:cav1
gene id: 8364:cav1
uniprot id: F7C9K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: Membrane raft
messages: caveola

8364:tmem14c
gene id: 8364:tmem14c
uniprot id: Q0V9B0
names: Similarity
messages: Belongs to the TMEM14 family.

8364:znf608
gene id: 8364:znf608
uniprot id: F6VGY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

8364:sec31a
gene id: 8364:sec31a
uniprot id: A0A6I8QQJ7
uniprot id: A0A6I8RKK2
uniprot id: A0A8J0PFG0
uniprot id: A0A8J0SSS4
uniprot id: A0A8J0SZT5
uniprot id: A0A8J0T283
uniprot id: A0A8J0T315
uniprot id: F6UZ63
uniprot id: Q5U4X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:LOC108646265
gene id: 8364:LOC108646265
uniprot id: A0A8J0T1P4
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100485197
gene id: 8364:LOC100485197
uniprot id: A0A8J1JFH4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116407775
gene id: 8364:LOC116407775
uniprot id: A0A8J1IVM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rnf182
gene id: 8364:rnf182
uniprot id: A4IHL7
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

8364:cuedc2
gene id: 8364:cuedc2
uniprot id: A0A8J1JRZ2
uniprot id: B1H0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

8364:apob
gene id: 8364:apob
uniprot id: A0A8J0QPQ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116408369
gene id: 8364:LOC116408369
uniprot id: A0A8J1IZI7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:mfsd14a
gene id: 8364:mfsd14a
uniprot id: Q28HV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8364:LOC100492329
gene id: 8364:LOC100492329
uniprot id: A0A8J1JJH4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:bchel
gene id: 8364:bchel
uniprot id: A0A6I8PZR8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8364:mapk6
gene id: 8364:mapk6
uniprot id: F7EB99
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

8364:dlgap1
gene id: 8364:dlgap1
uniprot id: A0A803J4E5
uniprot id: K9J889
names: Similarity
messages: Belongs to the SAPAP family.

8364:ptgfr
gene id: 8364:ptgfr
uniprot id: B2GUH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dgka
gene id: 8364:dgka
uniprot id: F7DBT3
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8364:hrh4.d1
gene id: 8364:hrh4.d1
uniprot id: A0A8J0R5P9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:fam160b1
gene id: 8364:fam160b1
uniprot id: A0A6I8SNQ8
uniprot id: B5DFN7
names: Similarity
messages: Belongs to the FHIP family.

8364:rrh
gene id: 8364:rrh
uniprot id: F7BYN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:LOC116406819
gene id: 8364:LOC116406819
uniprot id: A0A8J1IPS7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:nxph1
gene id: 8364:nxph1
uniprot id: B1H2N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

8364:wnt11
gene id: 8364:wnt11
uniprot id: B2GUT4
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Glycosylation is required for protein secretion.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Shares much functionality with wnt11b. Signals through a non-canonical Wnt pathway to activate Jun-N-terminal kinase (JNK) to regulate gastrulation movements. Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction. Acts redundantly with wnt11b during pronephros induction. Regulates cardiac morphogenesis through the activation of JNK, but is not required for cardiac differentiation. Essential for dorsal fin development; required for an epithelial to mesenchymal transformation event prior to migration of cells into the fin, and ultimately for maintenance of fin structure. Mediates dorsal fin development through a non-canonical pathway mediated by Ca(2+) (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Xenopus and other lower vertebrates contain duplicated wnt11 genes (wnt11 and wnt11b) resulting from an ancient gene duplication event, but the second copy has since been lost in mammals.
messages: extracellular matrix

8364:arhgef1
gene id: 8364:arhgef1
uniprot id: A0A8J0R5T2
uniprot id: A0A8J0R697
uniprot id: A0A8J0SJJ9
uniprot id: A0A8J0SRQ7
uniprot id: A0A8J0STC4
uniprot id: A0A8J0SU88
uniprot id: A0A8J0SUQ5
uniprot id: F7EIG6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

8364:LOC105945307
gene id: 8364:LOC105945307
uniprot id: A0A8J1JL77
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100494570
gene id: 8364:LOC100494570
uniprot id: A0A6I8RAX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

8364:LOC116408937
gene id: 8364:LOC116408937
uniprot id: A0A803KEJ3
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8364:idh3g
gene id: 8364:idh3g
uniprot id: F7D591
uniprot id: Q5BKK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

8364:ido1
gene id: 8364:ido1
uniprot id: Q6DFT5
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

8364:hpse
gene id: 8364:hpse
uniprot id: B1H188
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

8364:LOC100487982
gene id: 8364:LOC100487982
uniprot id: A0A6I8PWR1
uniprot id: A0A8J0R391
names: Subcellular Location Annotation
messages: Membrane

8364:lyrm9
gene id: 8364:lyrm9
uniprot id: A0A8J1J178
uniprot id: B4F6X2
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

8364:eya4
gene id: 8364:eya4
uniprot id: A0A6I8Q3R5
uniprot id: A0A6I8QCN4
uniprot id: A0A6I8QM81
uniprot id: A0A6I8QYY4
uniprot id: A0A6I8SJ20
uniprot id: A0A8J0QZI5
uniprot id: A0A8J0R3L9
uniprot id: A0A8J0R4A1
uniprot id: A0A8J0SNA9
uniprot id: A0A8J1JK71
uniprot id: A0A8J1JK72
uniprot id: A0A8J1JK73
uniprot id: A0A8J1JK77
uniprot id: A0A8J1JMM1
uniprot id: A0A8J1JMM6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

8364:gli2
gene id: 8364:gli2
uniprot id: A0A6I8RCT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

8364:rfc5
gene id: 8364:rfc5
uniprot id: Q5XGD2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

8364:vps18
gene id: 8364:vps18
uniprot id: B2GUB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

8364:fam193b
gene id: 8364:fam193b
uniprot id: A0A6I8RQA0
uniprot id: F6VYA8
names: Similarity
messages: Belongs to the FAM193 family.

8364:marveld3
gene id: 8364:marveld3
uniprot id: A0A6I8Q4V4
uniprot id: A0A8J0SKE5
uniprot id: A0A8J1JG83
uniprot id: Q28F40
names: Subcellular Location Annotation
messages: Membrane

8364:otx2
gene id: 8364:otx2
uniprot id: A0A8J0SW18
uniprot id: Q28FN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer gene cer1 by acting synergistically with siamois and mix-A/mix.1 through the 5'-TAATCT-3' element of the cer1 promoter. Also binds as a complex with lhx1/lim1 and ldb1 to the gsc promoter to stimulate expression (By similarity).
messages: Nucleus

8364:adora2b
gene id: 8364:adora2b
uniprot id: F6WC19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

8364:LOC100492238
gene id: 8364:LOC100492238
uniprot id: A0A803J2G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:LOC100497588
gene id: 8364:LOC100497588
uniprot id: A0A8J0QLE1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

8364:smad7
gene id: 8364:smad7
uniprot id: A0A8J0QYV9
uniprot id: F6X8Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8364:syce1
gene id: 8364:syce1
uniprot id: A0A803JD51
names: Similarity
messages: Belongs to the SYCE family.

8364:LOC100493138
gene id: 8364:LOC100493138
uniprot id: A0A1B8Y900
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:tmem80
gene id: 8364:tmem80
uniprot id: A0A6I8RIV0
names: Subcellular Location Annotation
messages: Membrane

8364:ube2t
gene id: 8364:ube2t
uniprot id: A0A6I8RVQ5
uniprot id: A0A803J6A4
uniprot id: A0A8J0R057
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:fbn1
gene id: 8364:fbn1
uniprot id: A0A6I8RXV1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:gdf1
gene id: 8364:gdf1
uniprot id: F6UHX6
names: Similarity
messages: Belongs to the TGF-beta family.

8364:muc5ac
gene id: 8364:muc5ac
uniprot id: A0A8J1JF16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:syn3
gene id: 8364:syn3
uniprot id: B3DLV0
names: Similarity
messages: Belongs to the synapsin family.

8364:cfd
gene id: 8364:cfd
uniprot id: Q6P326
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Probable serine protease.
messages: Secreted

8364:nudt1
gene id: 8364:nudt1
uniprot id: Q6GL35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

8364:celsr1
gene id: 8364:celsr1
uniprot id: A0A6I8RZT9
uniprot id: A0A8J0QIZ2
uniprot id: A0A8J1JDZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

8364:LOC116407573
gene id: 8364:LOC116407573
uniprot id: A0A8J1IW10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:LOC116408619
gene id: 8364:LOC116408619
uniprot id: A0A8J1J2P1
names: Subcellular Location Annotation
messages: Membrane

8364:cdca2
gene id: 8364:cdca2
uniprot id: A0A6I8Q0W4
names: Subcellular Location Annotation
messages: Nucleus

8364:ogfrl1
gene id: 8364:ogfrl1
uniprot id: A0A8J0SKB6
uniprot id: A0A8J0T0N3
uniprot id: A2VCV0
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

8364:mtr
gene id: 8364:mtr
uniprot id: A0A6I8QLS5
uniprot id: A0A8J1JM72
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

8364:kcnj8
gene id: 8364:kcnj8
uniprot id: A4IHW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:LOC116406653
gene id: 8364:LOC116406653
uniprot id: A0A8J1IN79
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:LOC100497169
gene id: 8364:LOC100497169
uniprot id: A0A803J724
names: Similarity
messages: Belongs to the cyclin family.

8364:LOC779590
gene id: 8364:LOC779590
uniprot id: A9JTJ7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:hoxd10
gene id: 8364:hoxd10
uniprot id: A0A6I8PNI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8364:arc3
gene id: 8364:arc3
uniprot id: B1WB66
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:slc2a12
gene id: 8364:slc2a12
uniprot id: A0A803KCI9
uniprot id: A0A8J0T3G2
uniprot id: F6XCZ1
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:med19
gene id: 8364:med19
uniprot id: A0A8J1JVJ3
uniprot id: B1H175
uniprot id: Q07FY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:LOC101731459
gene id: 8364:LOC101731459
uniprot id: A0A8J0QVB1
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:g6pc.3
gene id: 8364:g6pc.3
uniprot id: F6T2L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

8364:LOC101730283
gene id: 8364:LOC101730283
uniprot id: A0A8J0R121
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

8364:bdkrb2
gene id: 8364:bdkrb2
uniprot id: F7BR72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

8364:ccne1
gene id: 8364:ccne1
uniprot id: F6QUN0
uniprot id: Q28GD8
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

8364:map4k3
gene id: 8364:map4k3
uniprot id: A0A6I8RLL4
uniprot id: A0A6I8SAH1
uniprot id: A0A803KIM4
uniprot id: A0A8J0SNJ2
uniprot id: A0A8J1JHR5
uniprot id: A0A8J1JK74
uniprot id: A0A8J1JLC0
uniprot id: F6R1B6
uniprot id: F7BYG7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

8364:ncl
gene id: 8364:ncl
uniprot id: A0A8J1JLU7
names: Subcellular Location Annotation
messages: nucleolus

8364:nsun6
gene id: 8364:nsun6
uniprot id: Q66II9
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:metrnl
gene id: 8364:metrnl
uniprot id: A0A8J0PJ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the meteorin family.
messages: Secreted

8364:casd1
gene id: 8364:casd1
uniprot id: A0A6I8RSU1
uniprot id: A0A8J0SPB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

8364:LOC101734778
gene id: 8364:LOC101734778
uniprot id: A0A8J1IML7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8364:nms
gene id: 8364:nms
uniprot id: A0A6I8R5U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

8364:tle1
gene id: 8364:tle1
uniprot id: A0A6I8QL11
uniprot id: A0A8J0SLM5
uniprot id: D2JPI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

8364:celsr3
gene id: 8364:celsr3
uniprot id: A0A6I8S095
uniprot id: A0A6I8S9W5
uniprot id: A0A8J1JJ43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

8364:spop
gene id: 8364:spop
uniprot id: Q6P8B3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tdpoz family.
messages: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
messages: Homodimer. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and SPOP, plus a target protein (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The BTB (POZ) domain mediates dimerization and interaction with CUL3.
messages: The MATH domain mediates interaction with protein-ubiquitin ligase substrates.

8364:dmpk
gene id: 8364:dmpk
uniprot id: A0A6I8R374
uniprot id: A0A803J243
uniprot id: A0A803J4E1
uniprot id: A0A8J1IP85
uniprot id: A0A8J1IP88
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.

8364:galt
gene id: 8364:galt
uniprot id: Q504Q1
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

8364:suclg1
gene id: 8364:suclg1
uniprot id: Q5BKK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

8364:smpdl3b
gene id: 8364:smpdl3b
uniprot id: A0A8J1J6V1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

8364:mafa
gene id: 8364:mafa
uniprot id: Q4U1U2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Maf subfamily.
messages: During embryonic development, expressed in somites. First detected in stage 24 and remains excluded from the 2-3 caudal-most somites at all studied stages. First detectable in the developing hindbrain at stage 24. Expressed persists until stage 33. At stage 43, expressed in the olfactory bulb and thalamus.
messages: Nucleus
messages: Transcription factor, possibly involved in transcription regulation during lens development.

8364:chst2
gene id: 8364:chst2
uniprot id: F7EUT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

8364:LOC100492966
gene id: 8364:LOC100492966
uniprot id: A0A8J0QWG7
names: Subcellular Location Annotation
messages: Secreted

8364:gadl1
gene id: 8364:gadl1
uniprot id: A0A6I8RRP5
uniprot id: A0A8J1JN20
uniprot id: Q28D99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L-aspartate. Does not exhibit any decarboxylation activity toward glutamate.
messages: Homodimer.

8364:LOC116406822
gene id: 8364:LOC116406822
uniprot id: A0A8J1IPT2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:anapc16
gene id: 8364:anapc16
uniprot id: A0A8J0SQH0
uniprot id: A0A8J0ST47
uniprot id: A0A8J0STE2
uniprot id: Q6DJQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: The APC/C is composed of at least 12 subunits. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11 (By similarity).
messages: kinetochore

8364:themis
gene id: 8364:themis
uniprot id: F6UMP6
names: Similarity
messages: Belongs to the themis family.

8364:tmem39a
gene id: 8364:tmem39a
uniprot id: Q6GL42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Endoplasmic reticulum membrane
messages: Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity).

8364:tnfaip1
gene id: 8364:tnfaip1
uniprot id: A0A8J1J1W7
uniprot id: Q28DC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BACURD family.
messages: Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at least composed of cul3, tnfaip1/bacurd2 and rbx1.
messages: Cytoplasm
messages: Endosome
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

8364:ocm1
gene id: 8364:ocm1
uniprot id: A0A6I8PNF1
uniprot id: A0A803JT82
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8364:gusb
gene id: 8364:gusb
uniprot id: A0A6I8Q9V9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

8364:cyp2a13l
gene id: 8364:cyp2a13l
uniprot id: A0A8J1JI10
uniprot id: Q6DJB7
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:prkacb
gene id: 8364:prkacb
uniprot id: A0A803JUQ3
uniprot id: A0A8J1JEX4
uniprot id: F6UP78
uniprot id: F7DEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:atg4c
gene id: 8364:atg4c
uniprot id: A0A5S6LPV1
uniprot id: Q68EP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (By similarity).
messages: Cytoplasm

8364:ybey
gene id: 8364:ybey
uniprot id: A0A6I8S977
uniprot id: A0A8J0QIT7
uniprot id: A0A8J0R6P9
uniprot id: A0A8J0SNX7
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

8364:slc25a20l
gene id: 8364:slc25a20l
uniprot id: A0A803JL99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:LOC100495427
gene id: 8364:LOC100495427
uniprot id: A0A6I8S995
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:LOC100496244
gene id: 8364:LOC100496244
uniprot id: A0A8J0QWC9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC594905
gene id: 8364:LOC594905
uniprot id: A0A6I8PT16
uniprot id: A0A6I8PUW0
uniprot id: A0A6I8S7R8
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:foxp1
gene id: 8364:foxp1
uniprot id: A0A8J1JGQ9
uniprot id: A0A8J1JGR3
uniprot id: A0A8J1JGR5
uniprot id: A0A8J1JGR6
uniprot id: A0A8J1JGS0
uniprot id: A0A8J1JJ64
uniprot id: A0A8J1JJ69
uniprot id: A0A8J1JJ74
uniprot id: A0A8J1JK88
uniprot id: A0A8J1JK92
uniprot id: A0A8J1JKA1
names: Subcellular Location Annotation
messages: Nucleus

8364:gcsh
gene id: 8364:gcsh
uniprot id: Q63ZZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

8364:LOC116406836
gene id: 8364:LOC116406836
uniprot id: A0A8J1ISD9
names: Similarity
messages: Belongs to the GOLGA6 family.

8364:amigo3
gene id: 8364:amigo3
uniprot id: A0A6I8SIC2
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

8364:tmem123
gene id: 8364:tmem123
uniprot id: A0A6I8R7K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

8364:haus1
gene id: 8364:haus1
uniprot id: A8E5V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

8364:LOC100485132
gene id: 8364:LOC100485132
uniprot id: A0A8J1JHT2
names: Similarity
messages: Belongs to the TCAF family.

8364:g6pd
gene id: 8364:g6pd
uniprot id: A0A6I8SJ67
uniprot id: Q28DI9
uniprot id: Q5BKM9
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

8364:LOC100497717
gene id: 8364:LOC100497717
uniprot id: A0A8J1IS73
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:dnah12
gene id: 8364:dnah12
uniprot id: F6X5V5
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:ccni
gene id: 8364:ccni
uniprot id: A0A8J0SHP1
uniprot id: Q6DJQ8
names: Similarity
messages: Belongs to the cyclin family.

8364:LOC100485135
gene id: 8364:LOC100485135
uniprot id: A0A8J0T3C5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:aagab
gene id: 8364:aagab
uniprot id: F6TEM6
names: Similarity
messages: Belongs to the LIMR family.

8364:hoxb2
gene id: 8364:hoxb2
uniprot id: A0A6I8PJW3
names: Subcellular Location Annotation
messages: Nucleus

8364:mat1a
gene id: 8364:mat1a
uniprot id: A9JTV0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

8364:tmem54
gene id: 8364:tmem54
uniprot id: A0A7D9NMG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

8364:usp7
gene id: 8364:usp7
uniprot id: A0A6I8QN49
uniprot id: A0A6I8T0N1
uniprot id: A0A8J0SW02
names: Similarity
messages: Belongs to the peptidase C19 family.

8364:astl2d.5
gene id: 8364:astl2d.5
uniprot id: A0A8J1JEP9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gstm1
gene id: 8364:gstm1
uniprot id: Q6DIR0
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

8364:txlna
gene id: 8364:txlna
uniprot id: A0A8J0SDW6
uniprot id: B5DDW1
names: Similarity
messages: Belongs to the taxilin family.

8364:e2f7
gene id: 8364:e2f7
uniprot id: A0A5S6MB18
uniprot id: A0A8J0QXT9
uniprot id: F6Z1T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Belongs to the galactose-3-O-sulfotransferase family.
messages: Nucleus

8364:tatdn1
gene id: 8364:tatdn1
uniprot id: A0A6I8T2A4
uniprot id: A0A8J0SRN8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

8364:tspan16
gene id: 8364:tspan16
uniprot id: Q0V996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:sbk3
gene id: 8364:sbk3
uniprot id: A0A8J0QA98
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:shroom2
gene id: 8364:shroom2
uniprot id: A0A6I8REK1
uniprot id: Q09JY9
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: At stage 25, expressed throughout the eye field. At stage 40, expression becomes restricted to the retinal pigment epithelium.
messages: Belongs to the shroom family.
messages: Interacts with F-actin.
messages: May be involved in endothelial cell morphology changes during cell spreading. Required for eye pigmentation. In the retinal pigment epithelium, regulates the biogenesis of melanosomes and promotes their association with the apical cell surface by inducing gamma-tubulin redistribution.
messages: The ASD1 domain mediates F-actin binding.
messages: cytoskeleton
messages: tight junction

8364:colec10
gene id: 8364:colec10
uniprot id: Q5M8X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COLEC10/COLEC11 family.
messages: Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine.
messages: Secreted

8364:eif2b4
gene id: 8364:eif2b4
uniprot id: Q0V9M9
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

8364:eral1
gene id: 8364:eral1
uniprot id: F6WY27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

8364:il22ra1
gene id: 8364:il22ra1
uniprot id: A0A803JDQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

8364:LOC116408733
gene id: 8364:LOC116408733
uniprot id: A0A803JEV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

8364:wscd1
gene id: 8364:wscd1
uniprot id: Q0IIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

8364:sbk1l2
gene id: 8364:sbk1l2
uniprot id: A9JTT9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:cckar
gene id: 8364:cckar
uniprot id: F6R063
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:tef
gene id: 8364:tef
uniprot id: A0A8J1JDL9
uniprot id: F6SBH6
uniprot id: Q28DN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

8364:mael
gene id: 8364:mael
uniprot id: Q08D62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Cytoplasm
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).

8364:LOC100497309
gene id: 8364:LOC100497309
uniprot id: A0A8J0STY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tuba1cl.2
gene id: 8364:tuba1cl.2
uniprot id: A0A6I8R5I0
uniprot id: A0A803KCS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8364:tnfrsf25
gene id: 8364:tnfrsf25
uniprot id: A0A803KFV1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:bend5
gene id: 8364:bend5
uniprot id: F6SQJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

8364:ino80d
gene id: 8364:ino80d
uniprot id: A0A6I8Q373
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100495517
gene id: 8364:LOC100495517
uniprot id: A0A8J0QNE9
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:MGC147172
gene id: 8364:MGC147172
uniprot id: Q0P4K7
names: Similarity
messages: Belongs to the cornifelin family.

8364:accs
gene id: 8364:accs
uniprot id: A0A8J0T066
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116409617
gene id: 8364:LOC116409617
uniprot id: A0A8J1JC31
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116409745
gene id: 8364:LOC116409745
uniprot id: A0A8J1JCY6
names: Subcellular Location Annotation
messages: Membrane

8364:trpt1
gene id: 8364:trpt1
uniprot id: A0A8J1JF55
uniprot id: F7C4I0
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

8364:tfap2e
gene id: 8364:tfap2e
uniprot id: B3DL96
names: Similarity
messages: Belongs to the AP-2 family.

8364:elp3
gene id: 8364:elp3
uniprot id: Q6NVL5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Stabilizes transcriptional repressor snai1 by inhibiting its ubiquitination which promotes neural crest cell migration (By similarity).
messages: Component of the elongator complex (By similarity). Interacts with transcriptional repressors snai1 and snai2; interaction with snai1 inhibits its ubiquitination and stabilizes it (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

8364:t2r15
gene id: 8364:t2r15
uniprot id: Q2AB67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:b3gnt10
gene id: 8364:b3gnt10
uniprot id: A0A8J0QKN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:gabra5
gene id: 8364:gabra5
uniprot id: F6Y090
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:grik5
gene id: 8364:grik5
uniprot id: A0A6I8RZM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:rflcii
gene id: 8364:rflcii
uniprot id: A0A6I8R8C9
uniprot id: B1PT69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

8364:chd1
gene id: 8364:chd1
uniprot id: A0A6I8SD56
uniprot id: A0A8J1IU83
names: Subcellular Location Annotation
messages: Nucleus

8364:serp2
gene id: 8364:serp2
uniprot id: Q0V9K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

8364:fnip2
gene id: 8364:fnip2
uniprot id: A0A803J7N2
uniprot id: A0A803JCN3
uniprot id: A0A803JPN5
uniprot id: A0A8J0QVR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

8364:arl10
gene id: 8364:arl10
uniprot id: Q6P866
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8364:ak2
gene id: 8364:ak2
uniprot id: Q28F55
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

8364:foxc1
gene id: 8364:foxc1
uniprot id: Q68F77
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Plays a role at the gastrula stage for expression of several mesodermal and endodermal genes. At the late neurula stage, regulates expression of adhesion genes to maintain cell adhesion in the mesodermal germ layer.
messages: Monomer.
messages: Nucleus

8364:cbr1.1
gene id: 8364:cbr1.1
uniprot id: F6QPA0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:c6.1
gene id: 8364:c6.1
uniprot id: A0A6I8Q310
uniprot id: A0A8J1IX91
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:LOC100497196
gene id: 8364:LOC100497196
uniprot id: A0A8J1K137
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

8364:LOC108644463
gene id: 8364:LOC108644463
uniprot id: A0A8J0QSN3
uniprot id: F7BD03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM171 family.
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Membrane
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

8364:LOC116408373
gene id: 8364:LOC116408373
uniprot id: A0A8J1IZI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101732877
gene id: 8364:LOC101732877
uniprot id: A0A8J0R882
names: Subcellular Location Annotation
messages: Membrane

8364:amotl1
gene id: 8364:amotl1
uniprot id: B1H2L9
uniprot id: F6ZR70
names: Similarity
messages: Belongs to the angiomotin family.

8364:LOC116406865
gene id: 8364:LOC116406865
uniprot id: A0A8J1IQ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

8364:hhipl1l
gene id: 8364:hhipl1l
uniprot id: A0A6I8PWX7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:e2f1
gene id: 8364:e2f1
uniprot id: A0A803JHW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8364:kcnj13
gene id: 8364:kcnj13
uniprot id: A4IIS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:slc5a6
gene id: 8364:slc5a6
uniprot id: A0A803JZM2
uniprot id: A0A8J1JI05
uniprot id: A0A8J1JLK8
uniprot id: Q6DJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8364:LOC100498381
gene id: 8364:LOC100498381
uniprot id: A0A8J0QXY2
names: Subcellular Location Annotation
messages: Membrane

8364:LOC105945848
gene id: 8364:LOC105945848
uniprot id: A0A8J0SAN8
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

8364:cdc37
gene id: 8364:cdc37
uniprot id: Q28CE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

8364:rpa3
gene id: 8364:rpa3
uniprot id: B2RYX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

8364:thrsp
gene id: 8364:thrsp
uniprot id: A0A803JZA0
uniprot id: F6WQY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Belongs to the oxoprolinase family.
messages: Cytoplasm
messages: Nucleus

8364:cep55
gene id: 8364:cep55
uniprot id: A0A6I8QK96
uniprot id: A0A8J0R4U1
uniprot id: F6UU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Nucleus

8364:stard6
gene id: 8364:stard6
uniprot id: A0A6I8SUH9
uniprot id: F6QZJ0
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

8364:gpr157
gene id: 8364:gpr157
uniprot id: B4F750
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 5 family.
messages: Membrane

8364:brd1
gene id: 8364:brd1
uniprot id: A0A6I8S3Z4
uniprot id: A0A8J0SIR1
uniprot id: A0A8J1J7L3
uniprot id: Q0P4R0
names: Subcellular Location Annotation
messages: Nucleus

8364:tdo2
gene id: 8364:tdo2
uniprot id: Q5EBG2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.

8364:cyp2a6.10
gene id: 8364:cyp2a6.10
uniprot id: A0A803JXM1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:aldh9a1
gene id: 8364:aldh9a1
uniprot id: F6VC33
uniprot id: Q6DJQ3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8364:tas2r4
gene id: 8364:tas2r4
uniprot id: Q2AB70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:atf7ip
gene id: 8364:atf7ip
uniprot id: A0A6I8PKK1
uniprot id: A0A803JJR8
uniprot id: A0A8J0SKR3
uniprot id: A0A8J1JIR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

8364:LOC100491788
gene id: 8364:LOC100491788
uniprot id: A0A6I8PWB5
uniprot id: E2IFV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:aqp9
gene id: 8364:aqp9
uniprot id: F6QEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:cbfb
gene id: 8364:cbfb
uniprot id: A0A8J0QQ65
uniprot id: A0A8J0QY82
uniprot id: A0A8J0R2F7
uniprot id: A0A8J0R375
uniprot id: A0A8J0SD15
uniprot id: F7C1Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

8364:ess2
gene id: 8364:ess2
uniprot id: A0A803K5Z5
uniprot id: B1H164
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

8364:nsg1
gene id: 8364:nsg1
uniprot id: Q05B35
names: Similarity
messages: Belongs to the NSG family.

8364:srf
gene id: 8364:srf
uniprot id: A0A803KEQ1
uniprot id: A0A8J1JK41
names: Subcellular Location Annotation
messages: Nucleus

8364:slc8a2
gene id: 8364:slc8a2
uniprot id: F7ECJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

8364:lbr
gene id: 8364:lbr
uniprot id: A0A6I8RST4
uniprot id: B1WAQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

8364:brf1
gene id: 8364:brf1
uniprot id: F7BB98
names: Similarity
messages: Belongs to the TFIIB family.

8364:eaf2
gene id: 8364:eaf2
uniprot id: B5DDV6
names: Similarity
messages: Belongs to the EAF family.

8364:supt20hl1
gene id: 8364:supt20hl1
uniprot id: A0A803J4N3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8364:ube2g2
gene id: 8364:ube2g2
uniprot id: Q28I82
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:spcs2
gene id: 8364:spcs2
uniprot id: Q5M8Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
messages: Component of the signal peptidase complex paralog A (SPC-A) composed of a catalytic subunit sec11a and three accessory subunits spcs1, spcs2 and spcs3. Component of the signal peptidase complex paralog C (SPC-C) composed of a catalytic subunit sec11c and three accessory subunits spcs1, spcs2 and spcs3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Endoplasmic reticulum membrane

8364:impad1
gene id: 8364:impad1
uniprot id: Q28CL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily.
messages: Membrane

8364:elovl6
gene id: 8364:elovl6
uniprot id: A0A6I8Q261
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

8364:astl3c
gene id: 8364:astl3c
uniprot id: A0A6I8PVV4
uniprot id: A0A8J0SLY3
uniprot id: A0A8J0SU37
uniprot id: A0A8J0SX49
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:alg14
gene id: 8364:alg14
uniprot id: A0A6I8QY76
uniprot id: A0A8J0R0M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

8364:vdac3
gene id: 8364:vdac3
uniprot id: A0A6I8RLB0
uniprot id: A0A8J0SFE0
uniprot id: A0A8J0SIA2
uniprot id: F7A2F1
uniprot id: Q5M8U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

8364:slc13a4
gene id: 8364:slc13a4
uniprot id: A0A8J1J7Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8364:LOC116407923
gene id: 8364:LOC116407923
uniprot id: A0A8J1IWS5
names: Subcellular Location Annotation
messages: Secreted

8364:LOC108645137
gene id: 8364:LOC108645137
uniprot id: A0A8J0T0T3
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:ddx19b
gene id: 8364:ddx19b
uniprot id: Q6P887
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:galnt3
gene id: 8364:galnt3
uniprot id: A0A6I8QZT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC116410386
gene id: 8364:LOC116410386
uniprot id: A0A8J1JIX8
names: Similarity
messages: Belongs to the peptidase A1 family.

8364:LOC116406454
gene id: 8364:LOC116406454
uniprot id: A0A803K552
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

8364:nkx2-8
gene id: 8364:nkx2-8
uniprot id: Q6P8A8
names: Subcellular Location Annotation
messages: Nucleus

8364:tent5b
gene id: 8364:tent5b
uniprot id: F7E7M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TENT family.
messages: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner and participates in cytoplasmic polyadenylation (PubMed:34048638). May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs (By similarity).
messages: Cytoplasm
messages: Nucleus

8364:smad6
gene id: 8364:smad6
uniprot id: A0A6I8RVC3
uniprot id: A0A8J0R1N9
uniprot id: F6S4W2
uniprot id: F6ZWH0
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Golgi stack
messages: Nucleus
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8364:krt15.1
gene id: 8364:krt15.1
uniprot id: A0A6I8PTI3
names: Similarity
messages: Belongs to the intermediate filament family.

8364:ndufv2
gene id: 8364:ndufv2
uniprot id: Q28HQ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

8364:cul2
gene id: 8364:cul2
uniprot id: A0A6I8SHI2
uniprot id: F6VLY7
names: Similarity
messages: Belongs to the cullin family.

8364:pfkfb1
gene id: 8364:pfkfb1
uniprot id: A0A6I8Q823
uniprot id: A0A6I8R1S4
uniprot id: A0A8J0R680
uniprot id: A0A8J0SW91
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

8364:LOC116408402
gene id: 8364:LOC116408402
uniprot id: A0A8J1IZM1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:trabd2b
gene id: 8364:trabd2b
uniprot id: P0DJQ9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave wnt8. Required for head formation.
messages: Was named TIKI in reference to large-headed humanoid in Polynesian mythology.

8364:mtmr1
gene id: 8364:mtmr1
uniprot id: A0A6I8RGD9
uniprot id: A0A6I8RXH6
uniprot id: A0A6I8S5M7
uniprot id: A0A8J0SL71
uniprot id: A0A8J0SVT7
uniprot id: A0A8J0T538
uniprot id: F7D908
uniprot id: Q28BS1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:lamp5
gene id: 8364:lamp5
uniprot id: A4IGL3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Endosome membrane
messages: Glycosylated.
messages: Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
messages: Recycling endosome
messages: dendrite
messages: growth cone membrane
messages: synaptic vesicle membrane

8364:LOC116406843
gene id: 8364:LOC116406843
uniprot id: A0A8J1IQ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dyrk3
gene id: 8364:dyrk3
uniprot id: A0A6I8SFE7
uniprot id: F7CK14
uniprot id: Q66IF3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

8364:cyld
gene id: 8364:cyld
uniprot id: A0A6I8SGS6
uniprot id: A0A8J0SHP2
uniprot id: B1H1A4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

8364:mast4
gene id: 8364:mast4
uniprot id: A0A6I8R5M8
uniprot id: A0A6I8SEE3
uniprot id: A0A6I8SH47
uniprot id: A0A8J0QL46
uniprot id: A0A8J0SJF1
uniprot id: A0A8J1IYN3
uniprot id: A0A8J1IYP0
uniprot id: F6Z180
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

8364:sh3glb2
gene id: 8364:sh3glb2
uniprot id: F6XUZ3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

8364:LOC105948131
gene id: 8364:LOC105948131
uniprot id: A0A8J0SVE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:uqcr11
gene id: 8364:uqcr11
uniprot id: F7A2V2
names: Similarity
messages: Belongs to the MAGUK family.

8364:orc4
gene id: 8364:orc4
uniprot id: Q6GL43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

8364:tlr5
gene id: 8364:tlr5
uniprot id: A0A8J1JKV7
uniprot id: Q0V9N4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100497780
gene id: 8364:LOC100497780
uniprot id: A0A8J0QLF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:bod1
gene id: 8364:bod1
uniprot id: A0A1B8XZD9
uniprot id: Q68FB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
messages: centrosome
messages: kinetochore

8364:sox17b.1
gene id: 8364:sox17b.1
uniprot id: Q8AWH2
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed throughout all the deep and superficial endoderm during gastrulation. Expression then declines rapidly after gastrulation, however a small patch of endoderm cells behind the cement gland maintains expression even into tailbud stages.
messages: Interacts (via C-terminus) with ctnnb1/beta-catenin (via Armadillo repeats); this interaction is required for inhibition of wnt-signaling.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription activator. Doesn't appear to bind to the consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin-mediated signaling (By similarity).

8364:LOC100497764
gene id: 8364:LOC100497764
uniprot id: A0A8J0QY22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:spock2
gene id: 8364:spock2
uniprot id: A0A803JQ85
uniprot id: F7E3Y0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:pgap1
gene id: 8364:pgap1
uniprot id: A0A8J1ISR9
uniprot id: A0A8J1ISS7
uniprot id: A0A8J1IV64
uniprot id: A0A8J1IVY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:LOC100488102
gene id: 8364:LOC100488102
uniprot id: A0A6I8QDZ9
uniprot id: A0A8J1JNB5
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:ada2
gene id: 8364:ada2
uniprot id: A0A803JM66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

8364:etv3l
gene id: 8364:etv3l
uniprot id: A0A6I8PT21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8364:dgke
gene id: 8364:dgke
uniprot id: A0A6I8R4X4
uniprot id: A0A8J0S5I1
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8364:rin3
gene id: 8364:rin3
uniprot id: A0A8J0QIM5
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

8364:galnt11
gene id: 8364:galnt11
uniprot id: A0A8J1JMR8
uniprot id: Q6DJR8
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aberrant left-right patterning resulting in abnormal cardiac loops, including leftward and symmetric/midline loops.
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Interacts with notch1.
messages: Membrane
messages: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

8364:LOC116411026
gene id: 8364:LOC116411026
uniprot id: A0A8J1JL90
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:tcirg1
gene id: 8364:tcirg1
uniprot id: A0A6I8QDQ1
uniprot id: A0A8J1JSS4
uniprot id: A0A8J1JSU3
uniprot id: A0A8J1JV95
uniprot id: F6S802
uniprot id: Q28DM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

8364:cldn15.2
gene id: 8364:cldn15.2
uniprot id: A0A6I8PJH8
uniprot id: A0A6I8R6U1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8364:prpf4b
gene id: 8364:prpf4b
uniprot id: A0A8J0QS64
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

8364:wdr24
gene id: 8364:wdr24
uniprot id: A0A8J1IVA7
uniprot id: B4F6T9
names: Similarity
messages: Belongs to the WD repeat WDR24 family.

8364:pick1
gene id: 8364:pick1
uniprot id: A0A8J0PLA9
uniprot id: A0A8J1JDT2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

8364:hbegf
gene id: 8364:hbegf
uniprot id: A0A6I8QCY1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC108645659
gene id: 8364:LOC108645659
uniprot id: A0A8J1J2T3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:slco2b1
gene id: 8364:slco2b1
uniprot id: A0A803JJU8
uniprot id: A4IIQ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:afg1l
gene id: 8364:afg1l
uniprot id: A0A6I8PYX8
uniprot id: A0A6I8R4W4
names: Similarity
messages: Belongs to the AFG1 ATPase family.

8364:slc39a10
gene id: 8364:slc39a10
uniprot id: A0A6I8RFG7
names: Subcellular Location Annotation
messages: Membrane

8364:copg1
gene id: 8364:copg1
uniprot id: Q6P4J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8364:mis12
gene id: 8364:mis12
uniprot id: F7CIU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

8364:nrdc
gene id: 8364:nrdc
uniprot id: F7AJT5
names: Similarity
messages: Belongs to the peptidase M16 family.

8364:gls
gene id: 8364:gls
uniprot id: A0A6I8QNV7
uniprot id: A0A6I8RCG3
uniprot id: A0A8J1IVL9
uniprot id: F7AGX9
names: Similarity
messages: Belongs to the glutaminase family.

8364:fbn3
gene id: 8364:fbn3
uniprot id: A0A6I8RWU7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:c7h11orf88
gene id: 8364:c7h11orf88
uniprot id: A0A8J0SVP1
uniprot id: A0A8J0T532
names: Similarity
messages: Belongs to the HOATZ family.

8364:irx1
gene id: 8364:irx1
uniprot id: Q6F2E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds to the bmp4 promoter to repress gene expression and thus mediate down-regulation of bmp4 by wnt signaling. Controls multiple processes through bmp4-repression including neural plate development, neural crest specification and Spemann organizer development. Involved in the specification of the preplacodal field at the anterior border of the neural plate. Regulates the genetic cascade of interactions that are necessary for positioning the isthmus organizer and the formation of the midbrain-hindbrain boundary. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros. Acts principally as a transcriptional activator during pronephros development.
messages: Belongs to the TALE/IRO homeobox family.
messages: Expressed in the neural plate in overlapping patterns with other irx members, which all share an anterior border of expression. Also expressed in the mesoderm, placodes and notochord. Broadly expressed in the tailbud rhombencephalon (hindbrain). Outside the nervous system and at tailbud stages, expressed in the developing otic vesicle, branchial arches, prospective heart region and pronephros.
messages: Nucleus

8364:gmppb
gene id: 8364:gmppb
uniprot id: A0A5S6KW99
uniprot id: F6YP99
uniprot id: Q68EQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD18 family.
messages: Belongs to the transferase hexapeptide repeat family.
messages: Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids.
messages: Nucleus

8364:snupn
gene id: 8364:snupn
uniprot id: A0A8J0QFJ3
uniprot id: F6TAQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

8364:adam15
gene id: 8364:adam15
uniprot id: A0A803JB44
uniprot id: A0A803JNC6
uniprot id: A0A803K8I8
uniprot id: A0A803KCS0
uniprot id: A0A8J1INR5
uniprot id: A0A8J1IR62
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100496752
gene id: 8364:LOC100496752
uniprot id: F6XTM2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:alx4
gene id: 8364:alx4
uniprot id: F6Q1D5
names: Subcellular Location Annotation
messages: Nucleus

8364:timm22
gene id: 8364:timm22
uniprot id: Q5M7K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Core component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
messages: Mitochondrion inner membrane

8364:timm8b
gene id: 8364:timm8b
uniprot id: Q28GN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

8364:LOC108648264
gene id: 8364:LOC108648264
uniprot id: A0A8J0T5F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:pomgnt1
gene id: 8364:pomgnt1
uniprot id: F7D9W4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

8364:prpf4
gene id: 8364:prpf4
uniprot id: Q6P8A5
names: Subcellular Location Annotation
messages: Nucleus speckle

8364:c12orf49
gene id: 8364:c12orf49
uniprot id: B2GUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

8364:hibadh
gene id: 8364:hibadh
uniprot id: Q5BKJ0
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

8364:il18rap
gene id: 8364:il18rap
uniprot id: A0A6I8PS39
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8364:vbp1
gene id: 8364:vbp1
uniprot id: A0A8J0SUZ0
uniprot id: F6WTZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

8364:lmna
gene id: 8364:lmna
uniprot id: Q28BY8
names: Similarity
messages: Belongs to the intermediate filament family.

8364:exosc2
gene id: 8364:exosc2
uniprot id: F6RNA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

8364:LOC116410408
gene id: 8364:LOC116410408
uniprot id: A0A6I8RBL1
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

8364:fbxw8
gene id: 8364:fbxw8
uniprot id: F6QRF6
uniprot id: F6QRS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted
messages: axon
messages: perinuclear region

8364:pard3
gene id: 8364:pard3
uniprot id: A0A6I8PWP7
uniprot id: A0A6I8Q7C0
uniprot id: A0A6I8RMF4
uniprot id: A0A6I8SFX3
uniprot id: A0A6I8SJ51
uniprot id: A0A6I8SQZ9
uniprot id: A0A8J0R0F7
uniprot id: A0A8J0R538
uniprot id: A0A8J0R5J3
uniprot id: A0A8J0SSA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

8364:tspyl2
gene id: 8364:tspyl2
uniprot id: Q28DD8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

8364:mapk1
gene id: 8364:mapk1
uniprot id: Q28H11
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

8364:shtn1
gene id: 8364:shtn1
uniprot id: A0A803JAV6
uniprot id: A0A803JJV0
uniprot id: A0A8J0R5Q4
uniprot id: A0A8J1JXZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

8364:sorbs2
gene id: 8364:sorbs2
uniprot id: A0A8J1J280
uniprot id: A0A8J1J281
uniprot id: A0A8J1J287
uniprot id: A0A8J1J299
uniprot id: A0A8J1J2A1
uniprot id: A0A8J1J2A6
uniprot id: A0A8J1J2A7
uniprot id: A0A8J1J2B3
uniprot id: A0A8J1J2B4
uniprot id: A0A8J1J4M5
uniprot id: A0A8J1J5N0
uniprot id: A0A8J1J5P0
uniprot id: A0A8J1J5P7
uniprot id: A0A8J1J5R1
uniprot id: B4F6T4
uniprot id: F6YCU2
names: Subcellular Location Annotation
messages: focal adhesion

8364:cnp
gene id: 8364:cnp
uniprot id: A0A6I8RTA0
uniprot id: A0A8J0QVM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

8364:LOC100485981
gene id: 8364:LOC100485981
uniprot id: A0A6I8RWS1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:txnip
gene id: 8364:txnip
uniprot id: F7BFT7
names: Similarity
messages: Belongs to the arrestin family.

8364:jph3
gene id: 8364:jph3
uniprot id: F6RHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

8364:LOC116411006
gene id: 8364:LOC116411006
uniprot id: A0A8J1JL71
names: Subcellular Location Annotation
messages: Membrane

8364:capn5
gene id: 8364:capn5
uniprot id: Q6DIP0
names: Similarity
messages: Belongs to the peptidase C2 family.

8364:LOC100495255
gene id: 8364:LOC100495255
uniprot id: A0A6I8RFN9
uniprot id: A0A6I8T294
uniprot id: A0A8J1JMN5
names: Similarity
messages: Belongs to the SELO family.

8364:LOC100489234
gene id: 8364:LOC100489234
uniprot id: A0A6I8RD06
uniprot id: A0A803JZI3
uniprot id: A0A8J1J5U0
uniprot id: A0A8J1J5U2
uniprot id: A0A8J1J5U4
uniprot id: A0A8J1J5U6
uniprot id: A0A8J1J5U9
uniprot id: A0A8J1J5V1
uniprot id: A0A8J1J890
uniprot id: A0A8J1J896
names: Similarity
messages: Belongs to the TCAF family.

8364:gpr156
gene id: 8364:gpr156
uniprot id: A0A6I8RZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

8364:prpf18
gene id: 8364:prpf18
uniprot id: A0A6I8QAL6
uniprot id: F7DN99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

8364:mrpl30
gene id: 8364:mrpl30
uniprot id: A0A803JLY1
uniprot id: F7BI95
uniprot id: Q28FF8
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

8364:ube2u
gene id: 8364:ube2u
uniprot id: A0A6I8QZT0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8364:kcnv1
gene id: 8364:kcnv1
uniprot id: F6V1D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

8364:aspm
gene id: 8364:aspm
uniprot id: F6URN1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:LOC108647650
gene id: 8364:LOC108647650
uniprot id: A0A803KC88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

8364:ddx41
gene id: 8364:ddx41
uniprot id: A0A8J0QSV9
uniprot id: F6VY98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.
messages: Cytoplasm
messages: Nucleus

8364:LOC100497124
gene id: 8364:LOC100497124
uniprot id: F6TL36
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC101734160
gene id: 8364:LOC101734160
uniprot id: A0A8J0R263
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:dnajc22
gene id: 8364:dnajc22
uniprot id: A9ULE9
uniprot id: B7ZUI2
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

8364:mttp.1
gene id: 8364:mttp.1
uniprot id: A0A6I8T1L6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mmp24
gene id: 8364:mmp24
uniprot id: A0A6I8QJJ2
uniprot id: A0A8J1IXU9
names: Similarity
messages: Belongs to the peptidase M10A family.

8364:man2a2
gene id: 8364:man2a2
uniprot id: Q6DIG4
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

8364:cenpc
gene id: 8364:cenpc
uniprot id: A0A8J0QS85
uniprot id: A0A8J0SDQ1
uniprot id: F6PXD7
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

8364:LOC100487968
gene id: 8364:LOC100487968
uniprot id: A0A8J0SE11
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:mindy4
gene id: 8364:mindy4
uniprot id: A0A1B8Y9Y6
uniprot id: Q0VA42
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
messages: Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

8364:pcdhac2
gene id: 8364:pcdhac2
uniprot id: A0A803KB76
uniprot id: A0A8J1J9R3
uniprot id: A0A8J1J9R6
uniprot id: A0A8J1J9R7
uniprot id: A0A8J1JC80
uniprot id: A0A8J1JDA3
uniprot id: A0A8J1JDA7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8364:tmem147
gene id: 8364:tmem147
uniprot id: A0A8J1JSH3
uniprot id: Q28FY5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of the ribosome-associated endoplasmic reticulum translocon complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for the translocation in the endoplasmic reticulum and the biogenesis of multi-pass membrane proteins.

8364:slc13a4l
gene id: 8364:slc13a4l
uniprot id: Q566M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8364:mtap
gene id: 8364:mtap
uniprot id: A0A5S6KRA5
uniprot id: A0A803KL15
uniprot id: A0A8J0T358
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

8364:LOC100498055
gene id: 8364:LOC100498055
uniprot id: A0A8J1JW55
uniprot id: F6YPP8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

8364:ercc3
gene id: 8364:ercc3
uniprot id: B3DLX4
uniprot id: F6UIE1
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

8364:LOC105945137
gene id: 8364:LOC105945137
uniprot id: A0A803JK16
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8364:ndufa12
gene id: 8364:ndufa12
uniprot id: Q5XGC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8364:sprtn
gene id: 8364:sprtn
uniprot id: F6UH96
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autocatalytically cleaved in response to double-stranded DNA-binding: autocatalytic cleavage takes place in trans and leads to inactivation.
messages: Belongs to the Spartan family.
messages: Chromosome
messages: DNA-binding activates the protease activity: single-stranded DNA-binding specifically activates ability to cleave covalent DNA-protein cross-links (DPCs). In contrast, double-stranded DNA-binding specifically activates autocatalytic cleavage, and subsequent inactivation.
messages: DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (By similarity). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as top1, top2a, histones H3 and H4 (By similarity). Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs (By similarity). May also act as a 'reader' of ubiquitinated pcna: facilitates chromatin association of rad18 and is required for efficient pcna monoubiquitination, promoting a feed-forward loop to enhance pcna ubiquitination and translesion DNA synthesis. Acts as a regulator of translesion DNA synthesis by recruiting vcp/p97 to sites of DNA damage (By similarity).
messages: Homodimer.
messages: Nucleus
messages: The UBZ4-type zinc fingers mediate binding to 'Lys-48'- and 'Lys-63'-linked polyubiquitin.

8364:natd1
gene id: 8364:natd1
uniprot id: Q66IM5
names: Similarity
messages: Belongs to the NATD1 family.

8364:cltc
gene id: 8364:cltc
uniprot id: A0A8J0S7H5
uniprot id: A0A8J0SCE2
uniprot id: Q5XHB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

8364:ercc2
gene id: 8364:ercc2
uniprot id: Q66II2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

8364:ca10
gene id: 8364:ca10
uniprot id: A0A803JJ54
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

8364:fgfbp3
gene id: 8364:fgfbp3
uniprot id: Q0VFR4
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

8364:LOC105946316
gene id: 8364:LOC105946316
uniprot id: A0A8J0SE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100492682
gene id: 8364:LOC100492682
uniprot id: A0A8J1JAV9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ccnk
gene id: 8364:ccnk
uniprot id: Q0V9U3
names: Similarity
messages: Belongs to the cyclin family.

8364:cfi
gene id: 8364:cfi
uniprot id: Q4V785
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mau2
gene id: 8364:mau2
uniprot id: A0A6I8PU24
uniprot id: A0A6I8S729
uniprot id: A0A8J0PGN9
uniprot id: F6X457
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus
messages: nucleoplasm

8364:LOC100490298
gene id: 8364:LOC100490298
uniprot id: A0A6I8R6D2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8364:aip
gene id: 8364:aip
uniprot id: A0A8J0SSG6
uniprot id: Q28F49
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

8364:rpl7a
gene id: 8364:rpl7a
uniprot id: Q0VFA4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

8364:timm21
gene id: 8364:timm21
uniprot id: A0A8J0SG98
uniprot id: Q28HE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

8364:LOC100487264
gene id: 8364:LOC100487264
uniprot id: A0A8J0SB58
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:stoml2
gene id: 8364:stoml2
uniprot id: Q6GLC6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

8364:atat1
gene id: 8364:atat1
uniprot id: A0A8J0SUK3
uniprot id: B2RZF9
uniprot id: K9J8E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

8364:n6amt1
gene id: 8364:n6amt1
uniprot id: A0A6I8SRY4
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

8364:pus7l
gene id: 8364:pus7l
uniprot id: A0A803KK61
uniprot id: A9JTM8
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

8364:LOC108646252
gene id: 8364:LOC108646252
uniprot id: A0A8J0T1N4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:ppp2r2a
gene id: 8364:ppp2r2a
uniprot id: Q5XGH9
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

8364:sec13
gene id: 8364:sec13
uniprot id: Q6P812
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

8364:eda2r
gene id: 8364:eda2r
uniprot id: A0A8J0QVH7
uniprot id: A0A8J0R1V4
uniprot id: A0A8J0R3T3
uniprot id: A0A8J0T3E2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:cplane2
gene id: 8364:cplane2
uniprot id: A0A8J0PIT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

8364:mindy1
gene id: 8364:mindy1
uniprot id: A0A6I8PUD6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

8364:LOC101733382
gene id: 8364:LOC101733382
uniprot id: A0A8J1JQC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8364:ccnl1
gene id: 8364:ccnl1
uniprot id: F6VK61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

8364:btf3
gene id: 8364:btf3
uniprot id: A0A8J0PIV1
uniprot id: F6ZEI6
names: Similarity
messages: Belongs to the NAC-beta family.

8364:rrp1b
gene id: 8364:rrp1b
uniprot id: A0A803JB53
uniprot id: Q28CG7
names: Similarity
messages: Belongs to the RRP1 family.

8364:mblac1
gene id: 8364:mblac1
uniprot id: A0A6I8QXI2
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

8364:scin
gene id: 8364:scin
uniprot id: A0A7D9NK15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

8364:parp14.2
gene id: 8364:parp14.2
uniprot id: A0A8J0QZ24
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:scgn
gene id: 8364:scgn
uniprot id: Q0VFG3
names: Subcellular Location Annotation
messages: Cytoplasm

8364:slx1a
gene id: 8364:slx1a
uniprot id: A0A803JY65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
messages: Forms a heterodimer with SLX4.
messages: Nucleus

8364:gsk3b
gene id: 8364:gsk3b
uniprot id: A0A803J2W8
uniprot id: A0A8J0T0Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

8364:add1
gene id: 8364:add1
uniprot id: A0A6I8QMV5
uniprot id: A0A8J0S9M1
uniprot id: A0A8J0S9N5
uniprot id: A0A8J0SFP2
uniprot id: A0A8J0SHE7
uniprot id: A0A8J0SHF2
uniprot id: A0A8J0SHG1
uniprot id: A0A8J0SHG6
uniprot id: A0A8J0SHH8
uniprot id: A0A8J0SRZ4
uniprot id: A0A8J0SZ02
uniprot id: A0A8J0T1E9
uniprot id: A0A8J0T1F4
uniprot id: A0A8J0T1G0
uniprot id: A0A8J0T276
uniprot id: A0A8J1J6K7
uniprot id: F6QML3
uniprot id: Q6GL07
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

8364:st3gal5
gene id: 8364:st3gal5
uniprot id: D2U4U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:LOC116411524
gene id: 8364:LOC116411524
uniprot id: A0A8J1JPJ1
names: Subcellular Location Annotation
messages: Nucleus

8364:ptpru
gene id: 8364:ptpru
uniprot id: A0A6I8Q253
uniprot id: A0A6I8STX0
uniprot id: A0A8J0QT62
uniprot id: A0A8J0SDE3
uniprot id: A0A8J1J4G7
uniprot id: F7CBD1
uniprot id: F7EHY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane
messages: Nucleus

8364:rabac1
gene id: 8364:rabac1
uniprot id: A0A8J1JT03
uniprot id: Q0VFJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

8364:kcnb1
gene id: 8364:kcnb1
uniprot id: A0A803JWF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.
messages: Lateral cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: sarcolemma
messages: synaptosome

8364:mdm4
gene id: 8364:mdm4
uniprot id: A0A803JA46
uniprot id: A0A8J1J183
uniprot id: B5DFR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

8364:LOC100495198
gene id: 8364:LOC100495198
uniprot id: A0A8J0QMH7
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

8364:nme3
gene id: 8364:nme3
uniprot id: A0A6I8QKB7
uniprot id: Q6DEP3
names: Similarity
messages: Belongs to the NDK family.

8364:fam166b
gene id: 8364:fam166b
uniprot id: A8E5W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0605 family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

8364:muc6
gene id: 8364:muc6
uniprot id: A0A8J1JF02
uniprot id: A0A8J1JF04
uniprot id: A0A8J1JF05
uniprot id: A0A8J1JHG2
uniprot id: A0A8J1JIG5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:acaa1
gene id: 8364:acaa1
uniprot id: Q05AR0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

8364:dclk2
gene id: 8364:dclk2
uniprot id: A0A6I8R2X1
uniprot id: A0A6I8SG33
uniprot id: A0A8J1J0I1
uniprot id: L7N3N9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8364:LOC108646258
gene id: 8364:LOC108646258
uniprot id: A0A8J1JC09
names: Subcellular Location Annotation
messages: Membrane

8364:gpatch1
gene id: 8364:gpatch1
uniprot id: B1H130
uniprot id: F7C3S1
names: Similarity
messages: Belongs to the GPATCH1 family.

8364:pwp2
gene id: 8364:pwp2
uniprot id: A0A803KFH0
uniprot id: B2GUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

8364:glud1
gene id: 8364:glud1
uniprot id: Q5XGI4
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

8364:rpl3l
gene id: 8364:rpl3l
uniprot id: Q5BKH7
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

8364:adgrv1
gene id: 8364:adgrv1
uniprot id: A0A8J1IUN9
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116412005
gene id: 8364:LOC116412005
uniprot id: A0A8J1JSJ6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:LOC116409613
gene id: 8364:LOC116409613
uniprot id: A0A8J1J8K7
names: Subcellular Location Annotation
messages: Membrane

8364:ucn3
gene id: 8364:ucn3
uniprot id: F6QGE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

8364:rab33a
gene id: 8364:rab33a
uniprot id: F7AXL2
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

8364:smarca1
gene id: 8364:smarca1
uniprot id: A0A6I8S3L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

8364:vgll4
gene id: 8364:vgll4
uniprot id: A0A803JEH7
uniprot id: A0A8J1JDY0
uniprot id: Q0IHR7
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

8364:prokr1
gene id: 8364:prokr1
uniprot id: F6Y1C0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:slc39a4
gene id: 8364:slc39a4
uniprot id: A0A8J1JR47
uniprot id: F6U687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

8364:adm
gene id: 8364:adm
uniprot id: A0A6I8SCW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

8364:ddx43
gene id: 8364:ddx43
uniprot id: Q0P4V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:mrpl27
gene id: 8364:mrpl27
uniprot id: A4QNF8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

8364:prcp
gene id: 8364:prcp
uniprot id: Q08D72
names: Similarity
messages: Belongs to the peptidase S28 family.

8364:LOC108648073
gene id: 8364:LOC108648073
uniprot id: A0A8J0T4G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rrm2.2
gene id: 8364:rrm2.2
uniprot id: Q68EP1
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

8364:LOC116406817
gene id: 8364:LOC116406817
uniprot id: A0A8J1ISY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:esrra
gene id: 8364:esrra
uniprot id: A0JM86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8364:LOC116406781
gene id: 8364:LOC116406781
uniprot id: A0A803JY47
names: Similarity
messages: Belongs to the cyclin family.

8364:fut11
gene id: 8364:fut11
uniprot id: B3DL06
uniprot id: Q6A1G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Probable fucosyltransferase.

8364:dcp1b
gene id: 8364:dcp1b
uniprot id: A0A8J0R1F5
uniprot id: A0A8J0R260
uniprot id: F7ADT1
names: Similarity
messages: Belongs to the DCP1 family.

8364:chrnb4
gene id: 8364:chrnb4
uniprot id: A0A6I8RWF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:spock3
gene id: 8364:spock3
uniprot id: A0A8J0SJX5
uniprot id: A4II43
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116411629
gene id: 8364:LOC116411629
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:serf2
gene id: 8364:serf2
uniprot id: A0A6I8Q4B0
names: Similarity
messages: Belongs to the SERF family.

8364:pax3
gene id: 8364:pax3
uniprot id: A0A803K384
uniprot id: A0A8J0SVE4
uniprot id: A0A8J0SX77
uniprot id: L7N305
uniprot id: Q28DP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus
messages: Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neural crest, cooperating with zic1 and mediating signals from both the wnt and fgf8 signaling pathways. Induction of hatching gland cell fate is independent of zic1 (By similarity).

8364:bdh1
gene id: 8364:bdh1
uniprot id: F6RPF1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:vhl
gene id: 8364:vhl
uniprot id: A9ULN6
names: Similarity
messages: Belongs to the VHL family.

8364:tm9sf4
gene id: 8364:tm9sf4
uniprot id: A0A8J1IX71
uniprot id: A0A8J1IXC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

8364:fzd8
gene id: 8364:fzd8
uniprot id: A0A803J9G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

8364:gdf11.1
gene id: 8364:gdf11.1
uniprot id: L7N3U0
names: Similarity
messages: Belongs to the TGF-beta family.

8364:prorsd1p
gene id: 8364:prorsd1p
uniprot id: A0A6I8T0U6
names: Similarity
messages: Belongs to the PRORSD1 family.

8364:znf687
gene id: 8364:znf687
uniprot id: A0JP81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

8364:gngt2
gene id: 8364:gngt2
uniprot id: A4IHM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8364:LOC100493051
gene id: 8364:LOC100493051
uniprot id: A0A1B8Y747
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8364:tent5c
gene id: 8364:tent5c
uniprot id: F6ZWL0
names: Similarity
messages: Belongs to the TENT family.

8364:vgll3
gene id: 8364:vgll3
uniprot id: A0A803KLP5
uniprot id: L7MUK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

8364:spcs1
gene id: 8364:spcs1
uniprot id: A9ULB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:rad21
gene id: 8364:rad21
uniprot id: A0A8J1JN97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

8364:LOC101732075
gene id: 8364:LOC101732075
uniprot id: A0A8J1IZW9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:psmb6
gene id: 8364:psmb6
uniprot id: Q6P7M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8364:ccdc167
gene id: 8364:ccdc167
uniprot id: A0A8J1JHG7
uniprot id: A4QNG1
names: Subcellular Location Annotation
messages: Membrane

8364:dok5
gene id: 8364:dok5
uniprot id: A0A6I8RYN7
uniprot id: A0A8J1IYH3
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

8364:LOC108646191
gene id: 8364:LOC108646191
uniprot id: A0A8J1JBD3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:otulinl
gene id: 8364:otulinl
uniprot id: A0A6I8RQG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

8364:henmt1
gene id: 8364:henmt1
uniprot id: C0IN03
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. HEN1 family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

8364:fam114a2
gene id: 8364:fam114a2
uniprot id: A0A8J0QG86
names: Similarity
messages: Belongs to the FAM114 family.

8364:erg28
gene id: 8364:erg28
uniprot id: A0A8J1ILG3
uniprot id: A4IGS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:mrps25
gene id: 8364:mrps25
uniprot id: F7ABA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

8364:ap3m2
gene id: 8364:ap3m2
uniprot id: Q28IJ4
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

8364:ufd1
gene id: 8364:ufd1
uniprot id: F6TDH6
names: Similarity
messages: Belongs to the UFD1 family.

8364:sidt1
gene id: 8364:sidt1
uniprot id: A0A6I8PYA0
uniprot id: F7AAY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

8364:cadm4
gene id: 8364:cadm4
uniprot id: A0A6I8RYJ8
names: Similarity
messages: Belongs to the nectin family.

8364:wasf2
gene id: 8364:wasf2
uniprot id: F7E7Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

8364:slc30a10
gene id: 8364:slc30a10
uniprot id: A0A803JD46
uniprot id: A0A803KEV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8364:adamts18
gene id: 8364:adamts18
uniprot id: A0A6I8QIW1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:iqsec2
gene id: 8364:iqsec2
uniprot id: A0A8J0QSN9
uniprot id: A0A8J0R1S4
uniprot id: A0A8J0R3Q9
uniprot id: A0A8J0R662
uniprot id: A0A8J0R6L6
names: Similarity
messages: Belongs to the BRAG family.

8364:ppp1r3b
gene id: 8364:ppp1r3b
uniprot id: B3DL49
uniprot id: Q28E28
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown (By similarity).
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity (By similarity).
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.

8364:lgi4
gene id: 8364:lgi4
uniprot id: F6U6G9
uniprot id: Q28CE3
names: Subcellular Location Annotation
messages: Secreted

8364:h3c14
gene id: 8364:h3c14
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC101733893
gene id: 8364:LOC101733893
uniprot id: A0A8J1IMN0
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8364:atp6v0a1
gene id: 8364:atp6v0a1
uniprot id: A0A1B8Y5L8
uniprot id: A0A6I8QLS2
uniprot id: A0A6I8QZ29
uniprot id: A0A8J0SZS0
uniprot id: A0A8J1IW21
uniprot id: A0A8J1IYF6
uniprot id: A0A8J1IZ70
uniprot id: A1A5G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Melanosome
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits (By similarity).
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

8364:tmprss6
gene id: 8364:tmprss6
uniprot id: A0A6I8SQP4
uniprot id: A0A8J0QJK2
uniprot id: F6X0X4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:myh15
gene id: 8364:myh15
uniprot id: A0A6I8RQR3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:LOC116409649
gene id: 8364:LOC116409649
uniprot id: A0A8J1J8P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:gpr135
gene id: 8364:gpr135
uniprot id: A0A803JSB9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:acod1
gene id: 8364:acod1
uniprot id: A0A6I8PZZ7
uniprot id: A0A8J1J4Z5
names: Similarity
messages: Belongs to the PrpD family.

8364:rpsa
gene id: 8364:rpsa
uniprot id: Q6P8D1
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with rps21. Interacts with several laminins including at least lamb1. Interacts with mdk.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

8364:snx25
gene id: 8364:snx25
uniprot id: A0A6I8PXS4
uniprot id: A0A8J0T4U1
uniprot id: A0A8J1J0C1
uniprot id: F7BD13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: cytoskeleton
messages: sarcomere

8364:pcsk9
gene id: 8364:pcsk9
uniprot id: A0A803JS79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Cell surface
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Endosome
messages: Golgi apparatus
messages: Lysosome

8364:tmbim4
gene id: 8364:tmbim4
uniprot id: Q6DJB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8364:polr1a
gene id: 8364:polr1a
uniprot id: A0A6I8SZ42
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

8364:LOC101735020
gene id: 8364:LOC101735020
uniprot id: A0A8J0SZS1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:sult2b1
gene id: 8364:sult2b1
uniprot id: A0A803JR46
uniprot id: Q66KJ7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:ldb3
gene id: 8364:ldb3
uniprot id: A0A6I8RUY6
uniprot id: A0A6I8SAL2
uniprot id: A0A8J0R6B9
uniprot id: A0A8J0SIB0
uniprot id: A0A8J0SQA8
uniprot id: A0A8J0SQB3
uniprot id: A0A8J0SRX0
uniprot id: A0A8J0SSZ6
uniprot id: A0A8J0ST01
uniprot id: A0A8J0ST80
uniprot id: A0A8J0ST85
uniprot id: A0A8J0T5B6
uniprot id: A0A8J1JSA2
uniprot id: A0A8J1JSA4
uniprot id: A0A8J1JSB6
uniprot id: A0A8J1JSC0
uniprot id: A0A8J1JUR9
uniprot id: A0A8J1JUS4
uniprot id: Q6P644
names: Subcellular Location Annotation
messages: Z line

8364:LOC100487398
gene id: 8364:LOC100487398
uniprot id: A0A6I8SZ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cdcp2
gene id: 8364:cdcp2
uniprot id: A4IHD3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:mcm4
gene id: 8364:mcm4
uniprot id: Q6GL41
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the mcm2-7 complex (RLF-M). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5. The heterodimer of mmcm3/mcm5 interacts with mcm4, mmcm6, mcm7 and weakly with mcm2. Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45.
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Hyperphosphorylated during mitosis in a mechanism requiring cdc2-cyclin B and other kinases. Undergoes dephosphorylation after exiting mitosis, existing in a partially phosphorylated state in the cytosolic interphase mcm complex which associates with the pre-replication complexes (pre-Rcs). Complete dephosphorylation inactivates the mcm complex, preventing its binding to chromatin. Becomes actively phosphorylated during S phase once the mcm complex is assembled on the chromatin. This chromatin-associated phosphorylation occurs during the activation of the pre-Rcs and is independent of cdks. Phosphorylated by the cdc7-dbf4b complex (By similarity).
messages: Nucleus

8364:dnajc24
gene id: 8364:dnajc24
uniprot id: B5DDY4
names: Similarity
messages: Belongs to the DPH4 family.

8364:LOC100490346
gene id: 8364:LOC100490346
uniprot id: A0A8J1JA32
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:rybp
gene id: 8364:rybp
uniprot id: F6TN18
uniprot id: Q28DL7
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100485548
gene id: 8364:LOC100485548
uniprot id: A0A6I8S5P5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:frmd3
gene id: 8364:frmd3
uniprot id: Q0P4Q4
names: Subcellular Location Annotation
messages: Membrane

8364:gcg
gene id: 8364:gcg
uniprot id: A0A8J0SXW1
uniprot id: A0A8J1IS90
uniprot id: F7D9G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

8364:LOC116407597
gene id: 8364:LOC116407597
uniprot id: B5DDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:tbrg4
gene id: 8364:tbrg4
uniprot id: Q6DJ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAST kinase family.
messages: Mitochondrion matrix
messages: Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species. May play a role in cell cycle progression.

8364:mapkapk3
gene id: 8364:mapkapk3
uniprot id: F7C1G4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100486242
gene id: 8364:LOC100486242
uniprot id: A0A6I8QAH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8364:sfmbt2
gene id: 8364:sfmbt2
uniprot id: A0A6I8RUF3
uniprot id: F6XFP7
names: Subcellular Location Annotation
messages: Nucleus

8364:dmrtb1
gene id: 8364:dmrtb1
uniprot id: A0A6I8QDH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

8364:pitpnm2
gene id: 8364:pitpnm2
uniprot id: A0A6I8RW11
uniprot id: A0A8J0S8B5
uniprot id: A0A8J0SFH9
uniprot id: A0A8J0SGK1
uniprot id: A0A8J0SGK8
uniprot id: A0A8J1J399
uniprot id: A0A8J1J3B3
uniprot id: A0A8J1J3C2
uniprot id: A0A8J1J3D3
uniprot id: A0A8J1J5T0
uniprot id: A0A8J1J5T9
uniprot id: B5DE79
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

8364:sfrp4
gene id: 8364:sfrp4
uniprot id: A0A803J8T2
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:gns
gene id: 8364:gns
uniprot id: A9JRM2
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8364:neto1
gene id: 8364:neto1
uniprot id: A0A6I8T2B2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:rnaseh2a
gene id: 8364:rnaseh2a
uniprot id: Q6P7L6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

8364:LOC116409597
gene id: 8364:LOC116409597
uniprot id: A0A8J1J8J2
names: Subcellular Location Annotation
messages: Membrane

8364:ninj2
gene id: 8364:ninj2
uniprot id: A0A803K4K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

8364:LOC101734833
gene id: 8364:LOC101734833
uniprot id: A0A803JGB8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:tor2a
gene id: 8364:tor2a
uniprot id: A0A8J1J2Z9
uniprot id: Q28G83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

8364:foxn4
gene id: 8364:foxn4
uniprot id: A4IHZ1
names: Subcellular Location Annotation
messages: Nucleus

8364:fam83g
gene id: 8364:fam83g
uniprot id: A0A6I8RMM3
uniprot id: F6WTD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAM83 family.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

8364:tnmd
gene id: 8364:tnmd
uniprot id: A0A6I8PYX5
names: Similarity
messages: Belongs to the chondromodulin-1 family.

8364:ccdc107
gene id: 8364:ccdc107
uniprot id: A0A6I8PXZ5
names: Similarity
messages: Belongs to the ric-3 family.

8364:myo9b
gene id: 8364:myo9b
uniprot id: A0A6I8Q118
uniprot id: A0A8J0SX65
uniprot id: A0A8J0SX70
uniprot id: A0A8J0T438
uniprot id: A0A8J0T445
uniprot id: A0A8J0T6G6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:hdhd2
gene id: 8364:hdhd2
uniprot id: A0A8J1IZB7
uniprot id: B0BMS2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

8364:LOC550107
gene id: 8364:LOC550107
uniprot id: F7AKB7
uniprot id: Q07G21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

8364:tiparp
gene id: 8364:tiparp
uniprot id: A8E4V7
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:LOC105946911
gene id: 8364:LOC105946911
uniprot id: A0A8J1JAG3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:pappa2
gene id: 8364:pappa2
uniprot id: A0A6I8R3C2
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sbf1
gene id: 8364:sbf1
uniprot id: A0A6I8Q167
uniprot id: A0A6I8SP37
uniprot id: A0A803KK08
uniprot id: A0A8J0S8W7
uniprot id: A0A8J0SEM0
uniprot id: A0A8J0SGD1
uniprot id: A0A8J0SGD6
uniprot id: A0A8J0SHI9
uniprot id: A0A8J0SHJ3
uniprot id: F6Z409
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8364:ell2
gene id: 8364:ell2
uniprot id: F6THI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

8364:lrrc42
gene id: 8364:lrrc42
uniprot id: A0A6I8PUX8
uniprot id: A0A8J0QEV3
uniprot id: A0A8J0QGL6
uniprot id: A0A8J0SC25
names: Similarity
messages: Belongs to the LRRC42 family.

8364:zcchc17
gene id: 8364:zcchc17
uniprot id: Q6QX57
names: Subcellular Location Annotation
messages: nucleolus

8364:crisp1.7
gene id: 8364:crisp1.7
uniprot id: Q6P303
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:slc25a42
gene id: 8364:slc25a42
uniprot id: Q05AQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate.
messages: Mitochondrion inner membrane

8364:gal3st3
gene id: 8364:gal3st3
uniprot id: A0A8J1JKA7
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

8364:LOC100145493
gene id: 8364:LOC100145493
uniprot id: A0A8J0T2D8
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

8364:LOC100497953
gene id: 8364:LOC100497953
uniprot id: A0A6I8Q591
names: Caution
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8364:lrrtm3
gene id: 8364:lrrtm3
uniprot id: F6WHD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

8364:klhl22
gene id: 8364:klhl22
uniprot id: A0A8J0SIC3
uniprot id: A0A8J0ST21
uniprot id: A0A8J1JKF9
uniprot id: F6QJ00
uniprot id: Q08CY1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of cul3, klhl22 and rbx1.
messages: Lysosome
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL22) ubiquitin ligase complex could mediate the monoubiquitination of PLK1 and regulate its activity in spindle assembly checkpoint (SAC) and chromosome segregation. The BCR(KLHL22) ubiquitin ligase complex may also be responsible for the ubiquitin-dependent proteasomal degradation of DEPDC5 and the activation of the TORC1 pathway.
messages: centrosome
messages: cytosol
messages: spindle

8364:lcorl
gene id: 8364:lcorl
uniprot id: A0A6I8SB09
names: Subcellular Location Annotation
messages: Nucleus

8364:setd6
gene id: 8364:setd6
uniprot id: A0A8J0SK97
uniprot id: A4QNG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

8364:dpp3
gene id: 8364:dpp3
uniprot id: F7DZ42
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

8364:LOC100496592
gene id: 8364:LOC100496592
uniprot id: A0A8J0QU17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:grk1
gene id: 8364:grk1
uniprot id: F6T8Q5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8364:dtna
gene id: 8364:dtna
uniprot id: A0A6I8RQS7
uniprot id: A0A6I8SY53
uniprot id: A0A8J0SGL7
uniprot id: A0A8J0SNJ9
uniprot id: A0A8J0SNK4
uniprot id: A0A8J0SQ49
uniprot id: A0A8J0SR71
uniprot id: A0A8J0SRE3
uniprot id: A0A8J1JN37
uniprot id: A0A8J1JN43
uniprot id: A0A8J1JN45
uniprot id: A0A8J1JN48
uniprot id: A0A8J1JN51
uniprot id: A0A8J1JN53
uniprot id: A0A8J1JQJ4
uniprot id: A0A8J1JQK0
uniprot id: A0A8J1JQK6
uniprot id: A0A8J1JRV3
uniprot id: Q0V9N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

8364:cxcl9
gene id: 8364:cxcl9
uniprot id: A0A7D9NM09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8364:gja9
gene id: 8364:gja9
uniprot id: A0A6I8R8Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:sepsecs
gene id: 8364:sepsecs
uniprot id: Q28EN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

8364:LOC100491417
gene id: 8364:LOC100491417
uniprot id: A0A8J1JB58
names: Subcellular Location Annotation
messages: Membrane

8364:mindy3
gene id: 8364:mindy3
uniprot id: A0A8J1JMQ1
uniprot id: Q6NX27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
messages: Nucleus

8364:LOC100496941
gene id: 8364:LOC100496941
uniprot id: A0A8J0STX2
names: Subcellular Location Annotation
messages: Chromosome

8364:znf593
gene id: 8364:znf593
uniprot id: B0BLT0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity.
messages: The protein is largely disordered, with the exception of the zinc finger domain.
messages: nucleolus

8364:mcee
gene id: 8364:mcee
uniprot id: A0A803JSN8
uniprot id: F6UJX4
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

8364:zdhhc5
gene id: 8364:zdhhc5
uniprot id: A0A8J0SLR1
uniprot id: Q2THW2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:tmem209
gene id: 8364:tmem209
uniprot id: A0A4X2QWJ7
uniprot id: Q5M7R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Membrane
messages: Mitochondrion outer membrane

8364:ppic
gene id: 8364:ppic
uniprot id: A0A6I8PT71
uniprot id: A0A8J0QHL5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:LOC108646247
gene id: 8364:LOC108646247
uniprot id: A0A803KAE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:LOC100485787
gene id: 8364:LOC100485787
uniprot id: A0A6I8QU10
uniprot id: A0A8J0QWC3
uniprot id: A0A8J1JN67
uniprot id: F7D2B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8364:ptgs2
gene id: 8364:ptgs2
uniprot id: Q501R2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

8364:arl9
gene id: 8364:arl9
uniprot id: F6UGC3
uniprot id: F7BCF1
uniprot id: Q28FN2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Belongs to the small GTPase superfamily. Arf family.

8364:pcolce
gene id: 8364:pcolce
uniprot id: Q5CZL0
uniprot id: Q66IF4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8364:plp1
gene id: 8364:plp1
uniprot id: A0A803K714
uniprot id: Q4QQQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

8364:prss23
gene id: 8364:prss23
uniprot id: A9JTP0
names: Similarity
messages: Belongs to the peptidase S1B family.

8364:LOC100490929
gene id: 8364:LOC100490929
uniprot id: F6RT24
uniprot id: F7ES22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: Nucleus
messages: extracellular space

8364:garem2
gene id: 8364:garem2
uniprot id: A0A8J0QZW1
names: Similarity
messages: Belongs to the GAREM family.

8364:gstz1
gene id: 8364:gstz1
uniprot id: A0A8J0QVF2
uniprot id: F6XCK9
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

8364:atf2
gene id: 8364:atf2
uniprot id: A0A8J0R6J4
uniprot id: A0A8J0T6D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

8364:LOC100488770
gene id: 8364:LOC100488770
uniprot id: A0A8J0QJC4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8364:oprd1
gene id: 8364:oprd1
uniprot id: A0A6I8RRK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC105945342
gene id: 8364:LOC105945342
uniprot id: A0A8J0SC38
names: Subcellular Location Annotation
messages: Membrane

8364:enpp4
gene id: 8364:enpp4
uniprot id: Q0VA77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity).

8364:wee1
gene id: 8364:wee1
uniprot id: A0A8J1JFB4
uniprot id: A0A8J1JGD1
uniprot id: B1H303
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

8364:dimt1
gene id: 8364:dimt1
uniprot id: B1H127
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

8364:tshb
gene id: 8364:tshb
uniprot id: A0A6I8RBV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

8364:LOC101733630
gene id: 8364:LOC101733630
uniprot id: A0A8J0SMG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome

8364:stard8
gene id: 8364:stard8
uniprot id: A0A6I8RWS2
uniprot id: A0A6I8ST67
uniprot id: A0A8J0R5P3
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC101733880
gene id: 8364:LOC101733880
uniprot id: Q6DK82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:esr-5
gene id: 8364:esr-5
uniprot id: A9UMI5
names: Subunit
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

8364:LOC116411042
gene id: 8364:LOC116411042
uniprot id: A0A8J1JNR3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:asz1
gene id: 8364:asz1
uniprot id: A0A8J0SHT9
uniprot id: B2GU35
uniprot id: F7BRM5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.

8364:ogfr
gene id: 8364:ogfr
uniprot id: A0A8J0QU99
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

8364:kcnn3
gene id: 8364:kcnn3
uniprot id: A0A8J1ISI1
names: Subcellular Location Annotation
messages: Membrane

8364:pald1
gene id: 8364:pald1
uniprot id: Q6DIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paladin family.
messages: cytosol

8364:LOC116409495
gene id: 8364:LOC116409495
uniprot id: A0A8J1JAG8
names: Similarity
messages: Belongs to the TGF-beta family.

8364:adamts6
gene id: 8364:adamts6
uniprot id: A0A6I8R5U5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:opn5
gene id: 8364:opn5
uniprot id: A0A8J0QRX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8364:gap43
gene id: 8364:gap43
uniprot id: K9J896
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Cell membrane
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: filopodium membrane
messages: growth cone membrane

8364:pm20d1
gene id: 8364:pm20d1
uniprot id: Q08BT9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Lipoproteins are powerful coactivators of PM20D1 activity in vitro and NAA biosynthesis in vivo.
messages: Secreted
messages: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles.

8364:cyb5r1
gene id: 8364:cyb5r1
uniprot id: A0A8J1J2Y7
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

8364:shisa9
gene id: 8364:shisa9
uniprot id: A7MC48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shisa family. SHISA9 subfamily.
messages: Component of some AMPA receptors (ionotropic glutamate receptors) complex.
messages: Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).
messages: Synapse
messages: dendritic spine membrane

8364:ldah
gene id: 8364:ldah
uniprot id: A0A6I8PSP4
uniprot id: A0A8J1JLT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

8364:LOC100492899
gene id: 8364:LOC100492899
uniprot id: A0A6I8QVL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8364:pgm3
gene id: 8364:pgm3
uniprot id: A0A8J0SND8
uniprot id: B2GU36
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

8364:LOC116408576
gene id: 8364:LOC116408576
uniprot id: A0A8J1J2F4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:trmt1
gene id: 8364:trmt1
uniprot id: A0A6I8PXP5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

8364:LOC101730220
gene id: 8364:LOC101730220
uniprot id: A0A8J1JLV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8364:tmem59
gene id: 8364:tmem59
uniprot id: B1WBF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:fxyd3
gene id: 8364:fxyd3
uniprot id: Q28CV9
names: Similarity
messages: Belongs to the FXYD family.

8364:tada3
gene id: 8364:tada3
uniprot id: A0A8J0SBH2
uniprot id: Q66JG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context (By similarity).
messages: Nucleus

8364:prss16
gene id: 8364:prss16
uniprot id: F7B8X9
names: Similarity
messages: Belongs to the peptidase S28 family.

8364:il12b
gene id: 8364:il12b
uniprot id: A0A803JFD8
uniprot id: A0A803KES8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-12B family.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

8364:LOC100496462
gene id: 8364:LOC100496462
uniprot id: A0A8J1JXV5
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

8364:LOC108647431
gene id: 8364:LOC108647431
uniprot id: A0A8J0T0D5
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:uts2rl
gene id: 8364:uts2rl
uniprot id: A0A2Z5WPK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

8364:klhl25
gene id: 8364:klhl25
uniprot id: Q0D2A9
names: Function
names: Subunit
messages: Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of cul3, klhl25 and rbx1.
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated eif4ebp1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis.

8364:scn3a
gene id: 8364:scn3a
uniprot id: A0A8J0SWE1
uniprot id: A0A8J1IT15
uniprot id: A0A8J1IT19
uniprot id: A0A8J1IVF8
uniprot id: A0A8J1IW78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8364:pla2g2d
gene id: 8364:pla2g2d
uniprot id: A0A803K1C6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

8364:pigs
gene id: 8364:pigs
uniprot id: A8E4X4
uniprot id: F7C443
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:tspan36
gene id: 8364:tspan36
uniprot id: Q28J95
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:slc2a11
gene id: 8364:slc2a11
uniprot id: A0A6I8QCF2
uniprot id: A0A8J0QIR7
uniprot id: A0A8J1IRJ7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8364:onecut1.2
gene id: 8364:onecut1.2
uniprot id: A0A6I8QTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8364:med18
gene id: 8364:med18
uniprot id: B0JYV7
uniprot id: Q28GE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:obp
gene id: 8364:obp
uniprot id: Q58TV5
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8364:znf408
gene id: 8364:znf408
uniprot id: A0A6I8RUL5
names: Subcellular Location Annotation
messages: Nucleus

8364:hif1a
gene id: 8364:hif1a
uniprot id: F6VTE9
names: Subcellular Location Annotation
messages: Cytoplasm

8364:LOC101730653
gene id: 8364:LOC101730653
uniprot id: A0A8J1JUA5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:dph3
gene id: 8364:dph3
uniprot id: A0A803K5G1
names: Similarity
messages: Belongs to the DPH3 family.

8364:cnga3
gene id: 8364:cnga3
uniprot id: A0A6I8Q4T5
uniprot id: A0A8J1J779
uniprot id: F6TBQ4
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116409499
gene id: 8364:LOC116409499
uniprot id: A0A8J1J825
names: Subcellular Location Annotation
messages: Membrane

8364:rtn4
gene id: 8364:rtn4
uniprot id: A0A6I8Q2V6
uniprot id: A0A6I8RL82
uniprot id: A0A6I8SU39
uniprot id: A0A8J0SMT5
uniprot id: B2GUC1
uniprot id: F6ZNT8
uniprot id: F7EE38
uniprot id: Q4FZ84
uniprot id: Q6IFY5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:thoc7
gene id: 8364:thoc7
uniprot id: Q6P643
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC7 family.
messages: Component of the THO subcomplex of the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

8364:nodal
gene id: 8364:nodal
uniprot id: F7D1X6
names: Similarity
messages: Belongs to the TGF-beta family.

8364:LOC116410975
gene id: 8364:LOC116410975
uniprot id: A0A8J1JL22
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:capza2
gene id: 8364:capza2
uniprot id: Q07GA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

8364:LOC100487588
gene id: 8364:LOC100487588
uniprot id: A0A6I8SFV2
uniprot id: F7EU05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC496737
gene id: 8364:LOC496737
uniprot id: Q5M8J3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

8364:btbd19
gene id: 8364:btbd19
uniprot id: F7BHW9
names: Similarity
messages: Belongs to the Nav/unc-53 family.

8364:lrp1
gene id: 8364:lrp1
uniprot id: A0A7D9NLE9
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:npc2
gene id: 8364:npc2
uniprot id: A0A5S6LDJ9
uniprot id: Q66K95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

8364:dppa2
gene id: 8364:dppa2
uniprot id: B1H2Y1
names: Subcellular Location Annotation
messages: Nucleus

8364:rab18
gene id: 8364:rab18
uniprot id: Q28D30
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

8364:gpr137c
gene id: 8364:gpr137c
uniprot id: B0JZG6
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

8364:nf2
gene id: 8364:nf2
uniprot id: F7AZR8
uniprot id: Q0IIY8
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

8364:wnt16
gene id: 8364:wnt16
uniprot id: A4ZGN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:araf
gene id: 8364:araf
uniprot id: A0A803KBU8
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

8364:LOC100494742
gene id: 8364:LOC100494742
uniprot id: A0A6I8Q513
names: Similarity
messages: Belongs to the FAM20 family.

8364:zdhhc23
gene id: 8364:zdhhc23
uniprot id: A0A6I8PTS0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:ric3
gene id: 8364:ric3
uniprot id: Q0VFF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ric-3 family.
messages: Endoplasmic reticulum membrane
messages: Molecular chaperone which facilitates proper subunit assembly andsurface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (By similarity). May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors (By similarity).

8364:tm4sf1
gene id: 8364:tm4sf1
uniprot id: F6R9J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:tent5d
gene id: 8364:tent5d
uniprot id: A0A803J215
names: Similarity
messages: Belongs to the TENT family.

8364:uqcrh
gene id: 8364:uqcrh
uniprot id: A0A8J1JJH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

8364:hapln1
gene id: 8364:hapln1
uniprot id: F6QL53
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:tmem196
gene id: 8364:tmem196
uniprot id: A4IIU3
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116409596
gene id: 8364:LOC116409596
uniprot id: A0A8J1JAY0
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100497531
gene id: 8364:LOC100497531
uniprot id: A0A8J1IVV7
names: Similarity
messages: Belongs to the dynein heavy chain family.

8364:LOC100496596
gene id: 8364:LOC100496596
uniprot id: A0A8J1JPZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:pigf
gene id: 8364:pigf
uniprot id: B7ZT49
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:reep1
gene id: 8364:reep1
uniprot id: A0A6I8RNY4
uniprot id: A0A803J3K0
uniprot id: A0A803J6D3
uniprot id: A0A803JHU5
uniprot id: A0A8J1J293
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

8364:LOC100498051
gene id: 8364:LOC100498051
uniprot id: A0A8J0QMB3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:dhrs3
gene id: 8364:dhrs3
uniprot id: Q68ER5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:btg5.2
gene id: 8364:btg5.2
uniprot id: B0JZ08
uniprot id: Q4VA81
names: Similarity
messages: Belongs to the BTG family.

8364:thg1l
gene id: 8364:thg1l
uniprot id: A0A6I8S823
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

8364:LOC116409446
gene id: 8364:LOC116409446
uniprot id: A0A8J1J7X2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC105947503
gene id: 8364:LOC105947503
uniprot id: A0A8J0SQ08
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:c3orf70
gene id: 8364:c3orf70
uniprot id: F6TD01
names: Similarity
messages: Belongs to the UPF0524 family.

8364:cd200r1
gene id: 8364:cd200r1
uniprot id: A0A803JYV4
uniprot id: F7ACI5
uniprot id: L7N382
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: Belongs to the CD200R family.
messages: focal adhesion

8364:LOC101730430
gene id: 8364:LOC101730430
uniprot id: A0A6I8SKS3
uniprot id: A0A8J0R8J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

8364:hgh1
gene id: 8364:hgh1
uniprot id: Q66KK3
names: Similarity
messages: Belongs to the HGH1 family.

8364:slc9a3
gene id: 8364:slc9a3
uniprot id: A0A6I8S0S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

8364:rab33b
gene id: 8364:rab33b
uniprot id: Q66IK6
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

8364:LOC100498247
gene id: 8364:LOC100498247
uniprot id: A0A8J0QHU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:bcat1
gene id: 8364:bcat1
uniprot id: A0A803JL32
uniprot id: Q0P4T8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

8364:spout1
gene id: 8364:spout1
uniprot id: A0A6I8QG52
uniprot id: Q07GA7
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

8364:LOC101731311
gene id: 8364:LOC101731311
uniprot id: A0A8J1JEI0
names: Similarity
messages: Belongs to the phospholipid scramblase family.

8364:LOC108648358
gene id: 8364:LOC108648358
uniprot id: A0A8J1IP30
names: Similarity
messages: Belongs to the cyclin family.

8364:sema6a
gene id: 8364:sema6a
uniprot id: A0A6I8PYN2
uniprot id: A0A6I8QBL4
uniprot id: A0A6I8QKN3
uniprot id: A0A8J0SZV9
uniprot id: A0A8J0T158
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:ocm4.3
gene id: 8364:ocm4.3
uniprot id: A8E5S7
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8364:adgrg2
gene id: 8364:adgrg2
uniprot id: A0A803J9M2
uniprot id: A0A8J0T0Y5
uniprot id: A0A8J1J420
uniprot id: A0A8J1J423
uniprot id: A0A8J1J427
uniprot id: A0A8J1J6G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8364:igf2bp3
gene id: 8364:igf2bp3
uniprot id: A0A8J0PJ32
uniprot id: F6SCY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Cytoplasm
messages: Nucleus

8364:birc7
gene id: 8364:birc7
uniprot id: A0A803KFR0
uniprot id: A0A8J1IW49
uniprot id: A9JTP3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Auto-ubiquitinated, and degraded in a 2-step mechanism; a caspase-independent first step and a caspase-dependent second step.
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Phosphorylated via MAPK-dependent and CDK-dependent pathways during oocyte maturation. Phosphorylation does not appear to affect caspase inhibition or autoubiquitination activity.
messages: The BIR2 domain is required for caspase-inhibition.
messages: The C-terminal region containing the RING finger domain is required for the initial degradation step, and the final digestion of cleavage fragments.
messages: Weak apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Weak inhibitor of caspase activity.

8364:psmd6
gene id: 8364:psmd6
uniprot id: Q6P2Y7
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

8364:ywhab
gene id: 8364:ywhab
uniprot id: Q5XGC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.

8364:tmod2
gene id: 8364:tmod2
uniprot id: A0A8J0S8Y1
uniprot id: F7E7B8
names: Subcellular Location Annotation
messages: cytoskeleton

8364:slc12a9
gene id: 8364:slc12a9
uniprot id: A0A8J1JC82
uniprot id: F7A753
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

8364:ppil4
gene id: 8364:ppil4
uniprot id: B3DL92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:tmem230
gene id: 8364:tmem230
uniprot id: Q6DET5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

8364:mdh1
gene id: 8364:mdh1
uniprot id: Q6DIY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Cytoplasm
messages: Homodimer.

8364:taf8
gene id: 8364:taf8
uniprot id: Q28J24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF8 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp, and a number of TBP-associated factors (TAFs).
messages: Cytoplasm
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit tbp, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of tbp and TBP-associated factors (TAFs). Mediates both basal and activator-dependent transcription.

8364:nampt
gene id: 8364:nampt
uniprot id: Q5M7L4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

8364:gabrb2
gene id: 8364:gabrb2
uniprot id: A4IIN3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:atp6v0d1
gene id: 8364:atp6v0d1
uniprot id: A0JLY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8364:eme2
gene id: 8364:eme2
uniprot id: Q0IHN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EME1/MMS4 family.
messages: Interacts with mus81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.
messages: Interacts with mus81.
messages: Nucleus

8364:cav2
gene id: 8364:cav2
uniprot id: Q5FVY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

8364:abl2
gene id: 8364:abl2
uniprot id: A0A6I8QFK6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8364:cdh2
gene id: 8364:cdh2
uniprot id: B2GUA1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8364:ddx4
gene id: 8364:ddx4
uniprot id: A0A6I8RNW2
uniprot id: B1WAW5
uniprot id: Q28DG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8364:lamtor3-like
gene id: 8364:lamtor3-like
uniprot id: B4F6Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMTOR3 family.
messages: Late endosome membrane
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade.

8364:mok
gene id: 8364:mok
uniprot id: A0A6I8PR21
uniprot id: A0A8J0SLB4
uniprot id: Q0IHM7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:cnih4
gene id: 8364:cnih4
uniprot id: Q6P3N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery.
messages: Membrane

8364:ppm1a
gene id: 8364:ppm1a
uniprot id: A4IHV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

8364:pde10a
gene id: 8364:pde10a
uniprot id: A0A6I8RRR8
uniprot id: A0A6I8RY09
uniprot id: A0A6I8SSI8
uniprot id: A0A8J1JJ41
uniprot id: A0A8J1JJ42
uniprot id: A0A8J1JLJ8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8364:galnt15
gene id: 8364:galnt15
uniprot id: A0A803J7A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8364:cygb
gene id: 8364:cygb
uniprot id: Q6DEW1
names: Similarity
messages: Belongs to the globin family.

8364:cblc
gene id: 8364:cblc
uniprot id: A0A8J0QSR3
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

8364:phactr4
gene id: 8364:phactr4
uniprot id: A0A6I8SGX4
uniprot id: A0A803JMA4
uniprot id: A0A8J0SEJ3
uniprot id: A0A8J1J120
uniprot id: A0A8J1J126
uniprot id: F7EC58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Binds ppp1ca and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity).
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

8364:phactr3
gene id: 8364:phactr3
uniprot id: A0A6I8R278
uniprot id: A0A803KLG1
uniprot id: A0A8J1IW28
uniprot id: A0A8J1IZ80
uniprot id: A4IIQ5
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

8364:bco2
gene id: 8364:bco2
uniprot id: F6VQ24
uniprot id: Q6DIN7
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

8364:c19orf12
gene id: 8364:c19orf12
uniprot id: A0A803K085
uniprot id: A0A8J0SI48
uniprot id: Q6DJ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: Mitochondrion membrane
messages: cytosol

8364:LOC116408611
gene id: 8364:LOC116408611
uniprot id: A0A8J1J2N1
names: Subcellular Location Annotation
messages: Membrane

8364:lmnb2
gene id: 8364:lmnb2
uniprot id: A0A6I8S2R6
names: Similarity
messages: Belongs to the intermediate filament family.

8364:acvr2a
gene id: 8364:acvr2a
uniprot id: B5DDW8
uniprot id: F6R871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8364:ndufs2
gene id: 8364:ndufs2
uniprot id: Q6P2W0
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

8364:LOC101730642
gene id: 8364:LOC101730642
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC116409526
gene id: 8364:LOC116409526
uniprot id: A0A8J1J851
names: Subcellular Location Annotation
messages: Membrane

8364:cdk5rap3
gene id: 8364:cdk5rap3
uniprot id: A0A8J1IWG3
uniprot id: Q5I0B6
names: Similarity
messages: Belongs to the CDK5RAP3 family.

8364:khdrbs3
gene id: 8364:khdrbs3
uniprot id: F7DUZ1
names: Similarity
messages: Belongs to the KHDRBS family.

8364:LOC116407805
gene id: 8364:LOC116407805
uniprot id: A0A8J1IVR6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100498424
gene id: 8364:LOC100498424
uniprot id: F6QCC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8364:kif15
gene id: 8364:kif15
uniprot id: F7E7G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: spindle

8364:sptbn2
gene id: 8364:sptbn2
uniprot id: A0A6I8Q3M7
uniprot id: A0A6I8R4I5
uniprot id: A0A8J0SD73
uniprot id: F6UCE8
names: Similarity
messages: Belongs to the caprin family.
messages: Belongs to the spectrin family.

8364:LOC100496398
gene id: 8364:LOC100496398
uniprot id: A0A803K601
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:cfap53
gene id: 8364:cfap53
uniprot id: B1H1B8
names: Similarity
messages: Belongs to the CFAP53 family.

8364:LOC105945734
gene id: 8364:LOC105945734
uniprot id: A0A8J1JHD8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC105948111
gene id: 8364:LOC105948111
uniprot id: A0A8J0SWQ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:paqr8
gene id: 8364:paqr8
uniprot id: Q0IIS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8364:hoxc8
gene id: 8364:hoxc8
uniprot id: Q6DIE5
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116411741
gene id: 8364:LOC116411741
uniprot id: A0A8J1JTS6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:creb5
gene id: 8364:creb5
uniprot id: A0A6I8QT78
uniprot id: A0A8J0R0C3
uniprot id: A0A8J0SUP1
uniprot id: A0A8J1JTY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

8364:anapc4
gene id: 8364:anapc4
uniprot id: B4F754
uniprot id: B5DEU5
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

8364:hexim1
gene id: 8364:hexim1
uniprot id: A0A803KC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

8364:LOC105947845
gene id: 8364:LOC105947845
uniprot id: A0A8J0SRL2
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8364:actn4
gene id: 8364:actn4
uniprot id: A0A6I8RJ91
uniprot id: A0A8J0SVY0
uniprot id: A0A8J0T635
uniprot id: Q6DFP7
names: Similarity
messages: Belongs to the alpha-actinin family.

8364:abi2
gene id: 8364:abi2
uniprot id: A0A6I8RHN8
uniprot id: A0A803J8S3
uniprot id: A0A8J1ISC6
uniprot id: A0A8J1ISD7
uniprot id: A0A8J1ISD8
uniprot id: A0A8J1ISE1
uniprot id: A0A8J1ISE3
uniprot id: A0A8J1ISE9
uniprot id: A0A8J1IUU5
uniprot id: A0A8J1IVK4
uniprot id: A0A8J1IVK9
uniprot id: A0A8J1IVL7
uniprot id: A9UMR6
uniprot id: Q28HT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

8364:uts2b
gene id: 8364:uts2b
uniprot id: B1H380
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

8364:LOC100494804
gene id: 8364:LOC100494804
uniprot id: A0A6I8QGS9
uniprot id: F7BWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Peroxisome

8364:aldob
gene id: 8364:aldob
uniprot id: Q6P7Y9
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

8364:dbx2
gene id: 8364:dbx2
uniprot id: A0A6I8PQS6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116408382
gene id: 8364:LOC116408382
uniprot id: A0A8J1IZJ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:parp3
gene id: 8364:parp3
uniprot id: F7C163
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

8364:LOC116412008
gene id: 8364:LOC116412008
uniprot id: A0A8J1JSQ6
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:tgm3l.7
gene id: 8364:tgm3l.7
uniprot id: F6YIE1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8364:cga
gene id: 8364:cga
uniprot id: F6W2E6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer of an alpha and a beta chain.
messages: Secreted

8364:LOC100489361
gene id: 8364:LOC100489361
uniprot id: A0A8J0T657
names: Similarity
messages: Belongs to the peptidase M14 family.

8364:utrn
gene id: 8364:utrn
uniprot id: A0A6I8QGB1
uniprot id: A0A6I8SBI0
uniprot id: A0A8J1JIN2
uniprot id: A0A8J1JIN5
uniprot id: A0A8J1JL34
uniprot id: A0A8J1JM78
names: Function
names: Subcellular Location Annotation
messages: May play a role in anchoring the cytoskeleton to the plasma membrane.
messages: cytoskeleton

8364:plxnd1
gene id: 8364:plxnd1
uniprot id: A0A7D9NM50
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8364:st6galnac2
gene id: 8364:st6galnac2
uniprot id: A0A6I8Q1E2
uniprot id: A0A8J1IWA6
uniprot id: A4IIC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8364:frem2
gene id: 8364:frem2
uniprot id: F6TLU6
names: Similarity
messages: Belongs to the FRAS1 family.

8364:g6pc.1
gene id: 8364:g6pc.1
uniprot id: F6VZ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

8364:veph1
gene id: 8364:veph1
uniprot id: A0A8J1JK62
uniprot id: F6WB05
names: Similarity
messages: Belongs to the MELT/VEPH family.

8364:crygdl.25
gene id: 8364:crygdl.25
uniprot id: A0A8J0QWJ8
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:tardbp
gene id: 8364:tardbp
uniprot id: A0A6I8SMZ7
uniprot id: A0A8J0SRW4
uniprot id: G1K3B4
uniprot id: Q28F51
names: Caution
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: Mitochondrion
messages: Nucleus
messages: Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity.
messages: Stress granule
messages: The RRM domains can bind to both DNA and RNA.

8364:atp13a5l.3
gene id: 8364:atp13a5l.3
uniprot id: F6QPV7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:rad9b
gene id: 8364:rad9b
uniprot id: A0A8J0SD38
uniprot id: A0A8J1IVQ6
names: Similarity
messages: Belongs to the rad9 family.

8364:LOC100497076
gene id: 8364:LOC100497076
uniprot id: A0A8J1IPY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100493940
gene id: 8364:LOC100493940
uniprot id: A0A803K8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:rab11fip3
gene id: 8364:rab11fip3
uniprot id: A0A803JAL8
uniprot id: A0A8J0SVT8
uniprot id: A0A8J1IST9
uniprot id: A0A8J1ISU6
uniprot id: A0A8J1IV89
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

8364:prps1
gene id: 8364:prps1
uniprot id: A0A8J1IL33
uniprot id: Q6P830
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

8364:wnt3a
gene id: 8364:wnt3a
uniprot id: A0A6I8R910
uniprot id: A0A803J6C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:LOC100491612
gene id: 8364:LOC100491612
uniprot id: A0A8J0QN14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116406818
gene id: 8364:LOC116406818
uniprot id: A0A8J1IPT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:actr6
gene id: 8364:actr6
uniprot id: Q28HE6
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

8364:LOC116409593
gene id: 8364:LOC116409593
uniprot id: A0A8J1J8I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC101731454
gene id: 8364:LOC101731454
uniprot id: A0A8J1JTY1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:gja3
gene id: 8364:gja3
uniprot id: B0BM18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:esf1
gene id: 8364:esf1
uniprot id: A0A8J0SLW3
uniprot id: A0A8J0T3X3
uniprot id: A4QNN2
uniprot id: F7A0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

8364:tfec
gene id: 8364:tfec
uniprot id: A0A6I8QVN3
uniprot id: A0A803KCB8
uniprot id: A0A8J0SSA8
uniprot id: F7BRE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

8364:grik2
gene id: 8364:grik2
uniprot id: A0A6I8SEA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:rpl12
gene id: 8364:rpl12
uniprot id: A0A803K2A6
uniprot id: A0A8J1IL95
uniprot id: Q28FK6
uniprot id: Q68F82
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

8364:iah1
gene id: 8364:iah1
uniprot id: F7E4T5
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

8364:LOC100488328
gene id: 8364:LOC100488328
uniprot id: A0A8J1J0E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8364:cyp2d6
gene id: 8364:cyp2d6
uniprot id: Q5FW30
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:ncapg
gene id: 8364:ncapg
uniprot id: Q6P4X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

8364:hnrnpc
gene id: 8364:hnrnpc
uniprot id: A0A6I8PXC1
uniprot id: A0A8J0SJY3
uniprot id: Q6DET1
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

8364:LOC101730941
gene id: 8364:LOC101730941
uniprot id: A0A8J0SXL8
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8364:cpsf4l
gene id: 8364:cpsf4l
uniprot id: Q28DB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

8364:LOC100496339
gene id: 8364:LOC100496339
uniprot id: A0A8J0SK31
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:trim71
gene id: 8364:trim71
uniprot id: A0A803KAA6
uniprot id: A0A803KB34
uniprot id: A0A8J0R506
names: Similarity
messages: Belongs to the TRIM/RBCC family.

8364:myo10
gene id: 8364:myo10
uniprot id: A0A8J0QGS9
uniprot id: A0A8J1JMX2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:pcbd1
gene id: 8364:pcbd1
uniprot id: Q640A1
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

8364:t2r25
gene id: 8364:t2r25
uniprot id: Q2AB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:not
gene id: 8364:not
uniprot id: A0A8J0QDB8
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC116410967
gene id: 8364:LOC116410967
uniprot id: A0A8J1JPM7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:kcna3
gene id: 8364:kcna3
uniprot id: A0A7D9NM73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane

8364:MGC108429
gene id: 8364:MGC108429
uniprot id: A0A8J0SVQ8
uniprot id: F6V986
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

8364:pck2
gene id: 8364:pck2
uniprot id: A0A8J0SHA1
uniprot id: Q28I57
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

8364:LOC105945551
gene id: 8364:LOC105945551
uniprot id: A0A8J1JPZ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC105947584
gene id: 8364:LOC105947584
uniprot id: A0A8J1JUD4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:slc35a3.2
gene id: 8364:slc35a3.2
uniprot id: F7D8S5
uniprot id: Q6P651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

8364:LOC108645185
gene id: 8364:LOC108645185
uniprot id: A0A8J1JYJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8364:ccnb2
gene id: 8364:ccnb2
uniprot id: Q66KA1
names: Similarity
messages: Belongs to the cyclin family.

8364:pcmtd2
gene id: 8364:pcmtd2
uniprot id: Q28H16
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

8364:cfap36
gene id: 8364:cfap36
uniprot id: Q28IH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP36 family.
messages: Cytoplasm
messages: Nucleus
messages: flagellum

8364:dnajc27
gene id: 8364:dnajc27
uniprot id: A2VCZ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

8364:LOC100487643
gene id: 8364:LOC100487643
uniprot id: L7N2H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8364:vstm2b
gene id: 8364:vstm2b
uniprot id: Q0IJ12
names: Subcellular Location Annotation
messages: Membrane

8364:LOC101734092
gene id: 8364:LOC101734092
uniprot id: A0A8J1ILX8
names: Similarity
messages: Belongs to the cyclin family.

8364:tfdp1
gene id: 8364:tfdp1
uniprot id: Q5M8Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8364:LOC100495290
gene id: 8364:LOC100495290
uniprot id: A0A8J0SZN6
uniprot id: A0A8J0T083
uniprot id: A0A8J1IQ80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116412370
gene id: 8364:LOC116412370
uniprot id: A0A8J1JZF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:bscl2
gene id: 8364:bscl2
uniprot id: A0A803JGC0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:amhr2
gene id: 8364:amhr2
uniprot id: A0A8J1J5B4
uniprot id: A0A8J1J8R3
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

8364:cyb5r3
gene id: 8364:cyb5r3
uniprot id: B3DLY4
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

8364:slf2
gene id: 8364:slf2
uniprot id: A0A8J0R2Z2
uniprot id: F6ZZK7
names: Similarity
messages: Belongs to the FAM178 family.

8364:mep1a
gene id: 8364:mep1a
uniprot id: Q5FVY5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:mrpl15
gene id: 8364:mrpl15
uniprot id: A0A803KKG2
uniprot id: F6ZE02
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

8364:tshz2
gene id: 8364:tshz2
uniprot id: A0A803KCQ2
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

8364:asf1b
gene id: 8364:asf1b
uniprot id: Q6DIP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

8364:lmo2
gene id: 8364:lmo2
uniprot id: Q5M8V8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor that acts synergistically with tal1/scl and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate. Induces globin gene expression together with fgf (By similarity).

8364:rprd1b
gene id: 8364:rprd1b
uniprot id: A0A803KKK7
uniprot id: A0A8J0SPT4
uniprot id: F7DXF4
names: Similarity
messages: Belongs to the UPF0400 (RTT103) family.

8364:astl2d.1
gene id: 8364:astl2d.1
uniprot id: A0A803JSJ4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:psph
gene id: 8364:psph
uniprot id: A0A6I8R2I0
uniprot id: Q0IHZ7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

8364:dennd5b
gene id: 8364:dennd5b
uniprot id: A0A6I8RIJ9
uniprot id: A0A7D9NM80
uniprot id: A0A8J1J982
uniprot id: B5DE52
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC116406798
gene id: 8364:LOC116406798
uniprot id: A0A8J1ISW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:six4
gene id: 8364:six4
uniprot id: A0A8J0SX71
uniprot id: A0A8J1IPI8
uniprot id: F6Y0Z9
names: Subcellular Location Annotation
messages: Nucleus

8364:sema3e
gene id: 8364:sema3e
uniprot id: A0A6I8Q628
uniprot id: F6VFS1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid droplet

8364:hmox2
gene id: 8364:hmox2
uniprot id: Q08D70
names: Similarity
messages: Belongs to the heme oxygenase family.

8364:LOC105946956
gene id: 8364:LOC105946956
uniprot id: A0A8J1J8E9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gprc5cl1
gene id: 8364:gprc5cl1
uniprot id: Q5M7Q6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:stk11
gene id: 8364:stk11
uniprot id: Q28CV3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

8364:suds3
gene id: 8364:suds3
uniprot id: A0A8J0QUH7
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC394444
gene id: 8364:LOC394444
uniprot id: Q8AWX3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

8364:LOC116409853
gene id: 8364:LOC116409853
uniprot id: A0A8J1JFQ2
names: Similarity
messages: Belongs to the cornifelin family.

8364:limk2
gene id: 8364:limk2
uniprot id: A0A8J1J6X7
uniprot id: B5DED2
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

8364:adhfe1
gene id: 8364:adhfe1
uniprot id: A0A7D9NK53
uniprot id: A0A803KIE3
uniprot id: A0A8J1JQ50
uniprot id: Q6P371
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).
messages: Mitochondrion

8364:LOC108648117
gene id: 8364:LOC108648117
uniprot id: A0A803J739
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:dusp9
gene id: 8364:dusp9
uniprot id: F7EIM1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8364:tfdp2
gene id: 8364:tfdp2
uniprot id: A0A6I8RLC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8364:LOC100497240
gene id: 8364:LOC100497240
uniprot id: A0A8J0SW45
names: Subcellular Location Annotation
messages: Membrane

8364:htt
gene id: 8364:htt
uniprot id: A0A6I8RIL2
uniprot id: A0A6R5A4C7
uniprot id: A0A8J1IZY9
uniprot id: A0A8J1J007
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the huntingtin family.
messages: Cytoplasm
messages: May play a role in microtubule-mediated transport or vesicle function.
messages: Nucleus

8364:LOC101733758
gene id: 8364:LOC101733758
uniprot id: A0A8J0T253
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:nucb1
gene id: 8364:nucb1
uniprot id: Q6NVL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobindin family.
messages: Cytoplasm
messages: Secreted
messages: cis-Golgi network membrane

8364:itga11
gene id: 8364:itga11
uniprot id: A0A6I8Q8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8364:ric8a
gene id: 8364:ric8a
uniprot id: A0A8J0T254
uniprot id: A0A8J1JSB2
uniprot id: A0A8J1JSB3
uniprot id: A0A8J1JSC3
uniprot id: A0A8J1JSD0
uniprot id: A0A8J1JUS9
uniprot id: A0A8J1JUT4
uniprot id: A0A8J1JW47
uniprot id: Q6P4W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma (By similarity).
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

8364:snrnp70
gene id: 8364:snrnp70
uniprot id: Q66II8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins snrnp70/U1-70K, snrpa/U1-A and snrpc/U1-C.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrnp70 binds to the loop I region of U1-snRNA.
messages: Nucleus speckle
messages: The RRM domain mediates interaction with U1 RNA.
messages: nucleoplasm

8364:LOC101733091
gene id: 8364:LOC101733091
uniprot id: A0A8J0R6W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:LOC101733014
gene id: 8364:LOC101733014
uniprot id: A0A8J1JAV4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100144919
gene id: 8364:LOC100144919
uniprot id: A0A8J0SRI1
uniprot id: A0A8J0SST2
uniprot id: B0BLT9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8364:dusp13
gene id: 8364:dusp13
uniprot id: A0A6I8Q7W7
uniprot id: A0A803JWQ7
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8364:ephb4
gene id: 8364:ephb4
uniprot id: A0A8J1JFR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC108646285
gene id: 8364:LOC108646285
uniprot id: A0A8J0T1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:rraga
gene id: 8364:rraga
uniprot id: Q6GLA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

8364:tmem38a
gene id: 8364:tmem38a
uniprot id: Q6P8F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM38 family.
messages: Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
messages: Nucleus membrane
messages: Sarcoplasmic reticulum membrane

8364:best2
gene id: 8364:best2
uniprot id: Q6P851
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

8364:LOC100491339
gene id: 8364:LOC100491339
uniprot id: A0A803J1X2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:cbr1.2
gene id: 8364:cbr1.2
uniprot id: A0A6I8S0I2
uniprot id: A0A803JII7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:mrpl2
gene id: 8364:mrpl2
uniprot id: A4IIM1
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

8364:anapc13.2
gene id: 8364:anapc13.2
uniprot id: A0A6I8SLI6
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

8364:LOC100492689
gene id: 8364:LOC100492689
uniprot id: A0A8J1IPX2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:agk
gene id: 8364:agk
uniprot id: A0A803KED9
uniprot id: A4IGK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

8364:kdm1a
gene id: 8364:kdm1a
uniprot id: F6ZUK1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

8364:arid1a
gene id: 8364:arid1a
uniprot id: A0A8J0QQ51
names: Subcellular Location Annotation
messages: Nucleus

8364:slc27a3
gene id: 8364:slc27a3
uniprot id: F7CV59
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8364:LOC116407791
gene id: 8364:LOC116407791
uniprot id: A0A8J1IY32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100485069
gene id: 8364:LOC100485069
uniprot id: A0A8J1ISA6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:cnih1
gene id: 8364:cnih1
uniprot id: Q66JD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

8364:hsp90aa1.2
gene id: 8364:hsp90aa1.2
uniprot id: A0JMA1
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8364:podxl
gene id: 8364:podxl
uniprot id: A0A6I8SLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the podocalyxin family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: filopodium
messages: lamellipodium
messages: microvillus
messages: ruffle

8364:piwil1
gene id: 8364:piwil1
uniprot id: A0A6I8R924
uniprot id: F6VZI1
names: Similarity
messages: Belongs to the argonaute family.

8364:LOC116411507
gene id: 8364:LOC116411507
uniprot id: Q28D21
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

8364:LOC100497495
gene id: 8364:LOC100497495
uniprot id: A0A803KFH1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:selenot
gene id: 8364:selenot
uniprot id: Q6PBD1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.
messages: Endoplasmic reticulum membrane
messages: May contain a selenide-sulfide bond between Cys-51 and Sec-54. This bond is speculated to serve as redox-active pair (By similarity).
messages: Selenoprotein with thioredoxin reductase-like oxidoreductase activity.

8364:wnt7b
gene id: 8364:wnt7b
uniprot id: B0JYX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8364:zdhhc8
gene id: 8364:zdhhc8
uniprot id: Q2THW1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:LOC100497406
gene id: 8364:LOC100497406
uniprot id: A0A1B8XZW2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:ddah2
gene id: 8364:ddah2
uniprot id: Q6DJ04
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

8364:pop7
gene id: 8364:pop7
uniprot id: A4IGJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like Alba family.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: nucleolus

8364:gsta4
gene id: 8364:gsta4
uniprot id: Q28IT9
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

8364:lrrfip2
gene id: 8364:lrrfip2
uniprot id: A0A6I8QFV4
uniprot id: A0A6I8QTC2
uniprot id: A0A6I8T0V3
uniprot id: A0A8J0SFM5
uniprot id: A0A8J0SML7
uniprot id: A0A8J0SP45
uniprot id: A0A8J0SP49
uniprot id: A0A8J0SQ94
uniprot id: A0A8J0SQE4
uniprot id: A0A8J0T3U2
uniprot id: A0A8J1JMI8
uniprot id: A0A8J1JPZ0
uniprot id: A0A8J1JR84
uniprot id: B2GUE2
names: Function
names: Similarity
messages: Belongs to the LRRFIP family.
messages: May function as an activator of the canonical Wnt signaling pathway upstream of ctnnb1/beta-catenin. May be required for dorsal axis formation (By similarity).

8364:polr2l.2
gene id: 8364:polr2l.2
uniprot id: Q1ECU1
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

8364:ccdc39
gene id: 8364:ccdc39
uniprot id: Q0V9R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.
messages: cilium axoneme

8364:LOC116407815
gene id: 8364:LOC116407815
uniprot id: A0A8J1IVT0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC101735178
gene id: 8364:LOC101735178
uniprot id: A0A8J1JNT9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8364:LOC108648894
gene id: 8364:LOC108648894
uniprot id: A0A8J1IUG0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8364:rita1
gene id: 8364:rita1
uniprot id: F7CXA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RITA family.
messages: Cytoplasm
messages: Interacts with RBPJ/RBPSUH.
messages: Nucleus
messages: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

8364:top2b
gene id: 8364:top2b
uniprot id: A0A6I8RJA4
uniprot id: F7BGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

8364:cacng6
gene id: 8364:cacng6
uniprot id: A4IIP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

8364:mpdu1
gene id: 8364:mpdu1
uniprot id: Q28FR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

8364:scml2
gene id: 8364:scml2
uniprot id: A0A8J1J2C4
uniprot id: F6YNN0
uniprot id: Q0IHT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

8364:tspan9
gene id: 8364:tspan9
uniprot id: A0A803JZ76
uniprot id: A0A8J0SHM7
uniprot id: B0BM39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:cda
gene id: 8364:cda
uniprot id: Q28II3
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

8364:LOC100497171
gene id: 8364:LOC100497171
uniprot id: A0A6I8PT87
names: Similarity
messages: Belongs to the LCA5 family.

8364:LOC116409639
gene id: 8364:LOC116409639
uniprot id: A0A8J1J8N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:anapc13.1
gene id: 8364:anapc13.1
uniprot id: A0A1P0XRT5
uniprot id: Q28IW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Nucleus
messages: The APC/C is composed of at least 12 subunits.

8364:LOC108648947
gene id: 8364:LOC108648947
uniprot id: A0A8J0SXE0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:LOC116409638
gene id: 8364:LOC116409638
uniprot id: A0A8J1JC51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116408618
gene id: 8364:LOC116408618
uniprot id: A0A8J1J2P8
names: Subcellular Location Annotation
messages: Membrane

8364:cdh5
gene id: 8364:cdh5
uniprot id: F7C290
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Membrane

8364:crebl2
gene id: 8364:crebl2
uniprot id: A0A1B8Y957
uniprot id: A4IGK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus
messages: Probable regulator of creb1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle (By similarity).

8364:fggy
gene id: 8364:fggy
uniprot id: B1H1B0
names: Similarity
messages: Belongs to the FGGY kinase family.

8364:ypel5
gene id: 8364:ypel5
uniprot id: Q640U2
names: Similarity
messages: Belongs to the yippee family.

8364:smim22
gene id: 8364:smim22
uniprot id: A0A8J0SPE8
names: Subcellular Location Annotation
messages: Membrane

8364:mfsd3
gene id: 8364:mfsd3
uniprot id: A4IIA0
names: Subcellular Location Annotation
messages: Membrane

8364:fam3a
gene id: 8364:fam3a
uniprot id: Q68F80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

8364:fam13c
gene id: 8364:fam13c
uniprot id: A0A803J9U5
uniprot id: A0A8J1JWE8
uniprot id: A0A8J1JWE9
names: Similarity
messages: Belongs to the FAM13 family.

8364:hsd17b7
gene id: 8364:hsd17b7
uniprot id: A0A8J0PH40
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

8364:chrdl1
gene id: 8364:chrdl1
uniprot id: A0A803JV54
uniprot id: B1H2T8
names: Subcellular Location Annotation
messages: Secreted

8364:anxa6
gene id: 8364:anxa6
uniprot id: A0A6I8RKF2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

8364:tmem132c
gene id: 8364:tmem132c
uniprot id: A0A8J0T016
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

8364:rasgrp3
gene id: 8364:rasgrp3
uniprot id: A0A803J505
uniprot id: F7BJ20
names: Similarity
messages: Belongs to the RASGRP family.

8364:LOC100497729
gene id: 8364:LOC100497729
uniprot id: A0A1B8XTN0
uniprot id: A0A8J0R8D6
names: Similarity
messages: Belongs to the cornifelin family.

8364:klhl32
gene id: 8364:klhl32
uniprot id: F6ZZH4
names: Similarity
messages: Belongs to the actin family.

8364:paqr9
gene id: 8364:paqr9
uniprot id: A0A803J678
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8364:mcl1
gene id: 8364:mcl1
uniprot id: A0A6I8PM94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: nucleoplasm

8364:amy2a
gene id: 8364:amy2a
uniprot id: F6QEY0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

8364:slc50a1
gene id: 8364:slc50a1
uniprot id: Q5EAL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Mediates sugar transport across membranes.

8364:gatc
gene id: 8364:gatc
uniprot id: A0A8J0QLE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

8364:gdpgp1
gene id: 8364:gdpgp1
uniprot id: Q0V9F1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
messages: The ortholog in A.thaliana catalyzes the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

8364:psmb2
gene id: 8364:psmb2
uniprot id: Q5XH87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8364:arl8a
gene id: 8364:arl8a
uniprot id: Q6P8C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).

8364:LOC100493041
gene id: 8364:LOC100493041
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:elp2
gene id: 8364:elp2
uniprot id: A0A5S6N3Q0
uniprot id: Q5EBD9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ELP2 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Component of the elongator complex.
messages: Cytoplasm
messages: Folds into a two seven-bladed beta-propeller structure which is required for elongator complex assembly.
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

8364:srrt
gene id: 8364:srrt
uniprot id: A0A6I8S7C3
uniprot id: A0A7D9NL77
uniprot id: A0A8J1J7G7
names: Similarity
messages: Belongs to the ARS2 family.

8364:sf3b1
gene id: 8364:sf3b1
uniprot id: A0A6I8QK95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

8364:coro7
gene id: 8364:coro7
uniprot id: A0A6I8PPL7
uniprot id: A0A6I8QPT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

8364:cdh6
gene id: 8364:cdh6
uniprot id: A0A6I8R610
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8364:LOC100492280
gene id: 8364:LOC100492280
uniprot id: A0A6I8RHS2
uniprot id: A0A8J0QNM0
uniprot id: A0A8J1JTY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8364:slc32a1
gene id: 8364:slc32a1
uniprot id: Q6DIV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity).
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cytoplasmic vesicle membrane
messages: Juge et al. shows that SLC32A1 is a symporter of both 4-aminobutanoate or glycine or beta-alanine with Cl(-) that operates according an electrical gradient without the need for a chemical gradient (By similarity). However Farsi et al. and Egashira et al. confirm that SLC32A1 is an antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or glycine and exclude any coupling with chloride (By similarity).
messages: Presynapse

8364:ldb2
gene id: 8364:ldb2
uniprot id: A0A6I8SFW8
uniprot id: A0A6I8T2L9
names: Similarity
messages: Belongs to the LDB family.

8364:p2ry8
gene id: 8364:p2ry8
uniprot id: A0A803K885
uniprot id: F6Z3A8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:slc25a47
gene id: 8364:slc25a47
uniprot id: F6VSR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8364:zdhhc6
gene id: 8364:zdhhc6
uniprot id: A0A6I8Q0Y5
uniprot id: A4IGY0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:sh2d3c
gene id: 8364:sh2d3c
uniprot id: F6ZUY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

8364:megf8
gene id: 8364:megf8
uniprot id: A0A6I8PVR0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:arc2
gene id: 8364:arc2
uniprot id: A0A803K298
uniprot id: C4B802
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:bace2
gene id: 8364:bace2
uniprot id: B4F734
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane

8364:med7
gene id: 8364:med7
uniprot id: Q5BJ48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8364:parpbp
gene id: 8364:parpbp
uniprot id: Q28EM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus
messages: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability.

8364:LOC101730405
gene id: 8364:LOC101730405
uniprot id: A0A8J1IPW7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gpc1
gene id: 8364:gpc1
uniprot id: Q0V9W0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: O-glycosylated with heparan sulfate side chains.
messages: extracellular space

8364:sept2-a
gene id: 8364:sept2-a
uniprot id: Q5BKN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium. Required for the progression through mitosis through regulation of chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements including convergent extension during gastrulation. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Controls cell shape and not polarization of cells during convergent extension (By similarity).
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Can form heterooligomers with other family members and form filaments. Interacts with wdpcp (By similarity).
messages: cell cortex
messages: cilium membrane
messages: cytoskeleton
messages: spindle

8364:pgd
gene id: 8364:pgd
uniprot id: A0A6I8QLA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

8364:LOC116411748
gene id: 8364:LOC116411748
uniprot id: A0A8J1JTT7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:nadk
gene id: 8364:nadk
uniprot id: A0A8J1JSH6
uniprot id: Q6DJ74
names: Similarity
messages: Belongs to the NAD kinase family.

8364:LOC100493166
gene id: 8364:LOC100493166
uniprot id: A0A8J1IXY8
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8364:LOC100490872
gene id: 8364:LOC100490872
uniprot id: A0A8J0QL59
names: Similarity
messages: Belongs to the polyadenylate-binding protein type-1 family.

8364:LOC100490275
gene id: 8364:LOC100490275
uniprot id: A0A8J1JA94
names: Similarity
messages: Belongs to the CRISP family.

8364:LOC116410523
gene id: 8364:LOC116410523
uniprot id: A0A8J1JH80
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:ggact
gene id: 8364:ggact
uniprot id: F6T2W4
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

8364:kcnc4
gene id: 8364:kcnc4
uniprot id: A0A8J0QIF7
uniprot id: F6QX83
names: Subcellular Location Annotation
messages: Membrane

8364:hectd1
gene id: 8364:hectd1
uniprot id: A0A6I8PRC4
uniprot id: A0A8J0SVK7
uniprot id: B5DE01
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

8364:LOC100494929
gene id: 8364:LOC100494929
uniprot id: A0A6I8Q716
uniprot id: A0A6I8SVQ3
uniprot id: A0A6I8SYC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101734287
gene id: 8364:LOC101734287
uniprot id: F6XFQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

8364:LOC116408739
gene id: 8364:LOC116408739
uniprot id: A0A803JHY1
uniprot id: A0A803K2Z7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gmfg
gene id: 8364:gmfg
uniprot id: Q5BIZ3
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

8364:susd6
gene id: 8364:susd6
uniprot id: Q07G01
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:umod.3
gene id: 8364:umod.3
uniprot id: A0A7D9NLQ9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

8364:ippk
gene id: 8364:ippk
uniprot id: A0JM57
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

8364:adra1b
gene id: 8364:adra1b
uniprot id: A0A803JBF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

8364:ahcy
gene id: 8364:ahcy
uniprot id: Q28IH7
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

8364:ensa
gene id: 8364:ensa
uniprot id: Q6NVR1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Phosphorylation at Ser-67 by gwl during mitosis is essential for interaction with ppp2r2d (PR55-delta) and subsequent inactivation of PP2A.
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).

8364:LOC101733595
gene id: 8364:LOC101733595
uniprot id: A0A8J1JX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8364:nucb2
gene id: 8364:nucb2
uniprot id: A0A803JHK8
uniprot id: Q5EB33
names: Similarity
messages: Belongs to the nucleobindin family.

8364:sptssb
gene id: 8364:sptssb
uniprot id: B0S4Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPTSS family. SPTSSB subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with sptlc1; the interaction is direct. Component of the serine palmitoyltransferase (SPT) complex (By similarity).
messages: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (By similarity).

8364:map4k5
gene id: 8364:map4k5
uniprot id: A0A8J0SKE8
uniprot id: A0A8J0SV23
uniprot id: B4F6N7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

8364:LOC100486631
gene id: 8364:LOC100486631
uniprot id: A0A6I8STP1
uniprot id: F7BG32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

8364:gucy2f
gene id: 8364:gucy2f
uniprot id: A0A6I8S5T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

8364:crygdl.43
gene id: 8364:crygdl.43
uniprot id: A0A803K403
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC101733085
gene id: 8364:LOC101733085
uniprot id: A0A8J0R3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

8364:LOC100488935
gene id: 8364:LOC100488935
uniprot id: F7AIL8
names: Similarity
messages: Belongs to the TGF-beta family.

8364:slc25a3
gene id: 8364:slc25a3
uniprot id: A0A8J0SI03
uniprot id: A0A8J1J6Y4
uniprot id: Q6P7N3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

8364:nudt17
gene id: 8364:nudt17
uniprot id: A0A8J1IMQ0
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

8364:LOC116407651
gene id: 8364:LOC116407651
uniprot id: A0A803J7C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actinoporin family. Sea anemone subfamily.
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

8364:LOC116406815
gene id: 8364:LOC116406815
uniprot id: A0A8J1IPS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:parvb
gene id: 8364:parvb
uniprot id: F6UFK5
uniprot id: Q6GLA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

8364:acad8
gene id: 8364:acad8
uniprot id: A0A6I8QIR4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8364:LOC101732071
gene id: 8364:LOC101732071
uniprot id: A0A803KE40
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:mapk10
gene id: 8364:mapk10
uniprot id: A0A8J0QFD4
uniprot id: A0A8J0QGY5
uniprot id: A0A8J0T3H7
uniprot id: A0A8J1JHC4
uniprot id: A0A8J1JJR2
uniprot id: A0A8J1JKV4
uniprot id: A0A8J1JKW0
uniprot id: A0A8J1JKW5
uniprot id: A7MC39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

8364:irx4
gene id: 8364:irx4
uniprot id: A0A8J0QFZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

8364:fam83e
gene id: 8364:fam83e
uniprot id: A0A6I8RF06
names: Similarity
messages: Belongs to the FAM83 family.

8364:mthfr
gene id: 8364:mthfr
uniprot id: A4IIX8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

8364:scnn1b
gene id: 8364:scnn1b
uniprot id: Q0V998
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8364:mid1
gene id: 8364:mid1
uniprot id: Q6DEU6
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

8364:coa7
gene id: 8364:coa7
uniprot id: B1WAQ3
uniprot id: Q0V9D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: May be required for assembly of mitochondrial respiratory chain complexes.
messages: Mitochondrion intermembrane space

8364:il20
gene id: 8364:il20
uniprot id: A0A8J0SD44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

8364:csmd1
gene id: 8364:csmd1
uniprot id: A0A8J1JL26
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:b4galnt3
gene id: 8364:b4galnt3
uniprot id: A0A803J494
uniprot id: A0A803JB24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.

8364:h2ax
gene id: 8364:h2ax
uniprot id: A0A803J276
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:h2bc11
gene id: 8364:h2bc11
uniprot id: Q28J31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:kcnh4
gene id: 8364:kcnh4
uniprot id: A0A6I8QED4
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8364:med13
gene id: 8364:med13
uniprot id: A0A6I8S1G1
uniprot id: A0A8J0QW63
uniprot id: A0A8J0R0E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8364:cfh
gene id: 8364:cfh
uniprot id: A0A6I8RVD7
uniprot id: A0A803K9X7
uniprot id: A0A8J1JD52
uniprot id: A0A8J1JFM0
uniprot id: Q6P4Z0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:c2cd5
gene id: 8364:c2cd5
uniprot id: Q28BX9
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Binds 3 Ca(2+) ions per C2 domain.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: May be required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. May bind phospholipid membranes in a calcium-dependent manner (By similarity).
messages: The C2 domain binds to calcium and membrane lipids.
messages: cell cortex
messages: ruffle

8364:b3gnt3.2
gene id: 8364:b3gnt3.2
uniprot id: A0A8J0S5Z2
uniprot id: B1WAS0
uniprot id: F7CQK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8364:LOC105945570
gene id: 8364:LOC105945570
uniprot id: A0A8J0S621
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:babam2
gene id: 8364:babam2
uniprot id: Q6DJ78
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex, at least composed of uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and babam1/nba1. Component of the BRCA1-A complex, at least composed of brca1, bard1, uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and babam1/nba1. In the BRCA1-A complex, interacts directly with abraxas1, brcc3/brcc36 and babam1/nba1. Binds polyubiquitin. Component of the BRISC complex, at least composed of abraxas2, brcc3/brcc36, babam2 and babam1/nba1.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the brca1-bard1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: Nucleus

8364:itk
gene id: 8364:itk
uniprot id: A0A6I8S205
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8364:trmt12
gene id: 8364:trmt12
uniprot id: F6WN03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

8364:peli2
gene id: 8364:peli2
uniprot id: Q6P4Y5
names: Similarity
messages: Belongs to the pellino family.

8364:adgrf3
gene id: 8364:adgrf3
uniprot id: A0A8J1JL65
names: Subcellular Location Annotation
messages: Membrane

8364:rhbdd3
gene id: 8364:rhbdd3
uniprot id: A0A7D9N0L6
uniprot id: Q28FJ5
names: Subcellular Location Annotation
messages: Membrane

8364:tspan8
gene id: 8364:tspan8
uniprot id: Q28GV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8364:ercc5
gene id: 8364:ercc5
uniprot id: A0A8J0SE75
uniprot id: A4IJ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

8364:emx1l
gene id: 8364:emx1l
uniprot id: A0A6I8PUW5
names: Subcellular Location Annotation
messages: Nucleus

8364:myf5
gene id: 8364:myf5
uniprot id: Q8QG50
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8364:ube2f
gene id: 8364:ube2f
uniprot id: Q5M8Y2
names: Function
names: Similarity
names: Subunit
messages: Accepts the ubiquitin-like protein NEDD8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx2, but not rbx1, suggests that the rbx2-ube2f complex neddylates specific target proteins, such as cul5.
messages: Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
messages: Interacts with uba3 and rbx2.

8364:ctsz
gene id: 8364:ctsz
uniprot id: A8E5S3
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:LOC105947920
gene id: 8364:LOC105947920
uniprot id: A0A8J0T5N2
names: Similarity
messages: Belongs to the Izumo family.

8364:LOC108648950
gene id: 8364:LOC108648950
uniprot id: A0A8J1IZ83
names: Similarity
messages: Belongs to the tubulin family.

8364:insl5
gene id: 8364:insl5
uniprot id: A0A6I8SQK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

8364:serpinb10
gene id: 8364:serpinb10
uniprot id: A0A6I8Q2E6
names: Similarity
messages: Belongs to the serpin family.

8364:fam149b1
gene id: 8364:fam149b1
uniprot id: A0A6I8PR43
names: Similarity
messages: Belongs to the FAM149 family.

8364:piwil4
gene id: 8364:piwil4
uniprot id: F7BXD6
names: Similarity
messages: Belongs to the argonaute family.

8364:arpc1b
gene id: 8364:arpc1b
uniprot id: Q6DF56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

8364:tbc1d12
gene id: 8364:tbc1d12
uniprot id: Q0IHY4
names: Function
messages: May act as a GTPase-activating protein for Rab family protein(s).

8364:LOC108648869
gene id: 8364:LOC108648869
uniprot id: A0A1B8XZW2
uniprot id: Q28D37
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:ufl1
gene id: 8364:ufl1
uniprot id: F6RS91
names: Similarity
messages: Belongs to the UFL1 family.

8364:ndnfl1.1
gene id: 8364:ndnfl1.1
uniprot id: F6UG11
uniprot id: F7BFF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane
messages: Secreted

8364:prmt2
gene id: 8364:prmt2
uniprot id: A0A6I8Q0B5
uniprot id: A0A6I8SZ82
uniprot id: B3DLB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as histones. Involved in growth regulation. Involved in embryonic dorsal development.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Cytoplasm
messages: Interacts with ctnnb1.
messages: Nucleus

8364:cmtr1
gene id: 8364:cmtr1
uniprot id: A0A1B8XX56
uniprot id: B3DLX8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

8364:slc45a4
gene id: 8364:slc45a4
uniprot id: F7D1N3
names: Subcellular Location Annotation
messages: Membrane

8364:LOC116406785
gene id: 8364:LOC116406785
uniprot id: A0A6I8Q4Q7
names: Similarity
messages: Belongs to the cyclin family.

8364:cfdp1
gene id: 8364:cfdp1
uniprot id: F6RJQ7
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

8364:rps26
gene id: 8364:rps26
uniprot id: Q6DDC9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

8364:LOC100492630
gene id: 8364:LOC100492630
uniprot id: A0A803JLZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8364:caskin1
gene id: 8364:caskin1
uniprot id: A0A6I8QTH2
uniprot id: A0A8J0QJ55
uniprot id: A0A8J1IT43
uniprot id: F7BS58
names: Subcellular Location Annotation
messages: Cytoplasm

8364:krt78.1
gene id: 8364:krt78.1
uniprot id: A0A6I8S2K8
uniprot id: A0A8J0QRM2
names: Similarity
messages: Belongs to the intermediate filament family.

8364:nmnat1
gene id: 8364:nmnat1
uniprot id: A0A6I8R4G8
uniprot id: A0A803KH58
uniprot id: A0A8J0PIG0
uniprot id: A0A8J0STW4
uniprot id: F7E1Z3
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

8364:rilpl2
gene id: 8364:rilpl2
uniprot id: Q0P4J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RILPL family.
messages: Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport (By similarity).
messages: centrosome
messages: cilium
messages: cytosol

8364:trpc6
gene id: 8364:trpc6
uniprot id: A0A8J1J5N8
uniprot id: F6V4A4
names: Subcellular Location Annotation
messages: Membrane

8364:acacb
gene id: 8364:acacb
uniprot id: F6SGV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8364:pla2g4d
gene id: 8364:pla2g4d
uniprot id: A0A6I8R706
uniprot id: F6V411
names: Domain
names: Subcellular Location Annotation
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.
messages: cytosol

8364:LOC116412401
gene id: 8364:LOC116412401
uniprot id: A0A8J1JX25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:crtac1
gene id: 8364:crtac1
uniprot id: A0A8J0SSQ5
uniprot id: A0A8J1JT24
uniprot id: Q0V9M0
names: Caution
names: Subcellular Location Annotation
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8364:fam166c
gene id: 8364:fam166c
uniprot id: A4II40
names: Similarity
messages: Belongs to the FAM166C family.

8364:taf5l
gene id: 8364:taf5l
uniprot id: Q6DIG0
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

8364:slc5a1.1
gene id: 8364:slc5a1.1
uniprot id: A0A803J7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8364:LOC116411017
gene id: 8364:LOC116411017
uniprot id: A0A8J1JL80
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:exoc3
gene id: 8364:exoc3
uniprot id: Q6DJR6
names: Similarity
messages: Belongs to the SEC6 family.

8364:LOC105945162
gene id: 8364:LOC105945162
uniprot id: A0A8J1JVH3
names: Subcellular Location Annotation
messages: Cytoplasm

8364:eif5a
gene id: 8364:eif5a
uniprot id: Q6DK71
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

8364:tesmin
gene id: 8364:tesmin
uniprot id: A0A8J0T2C2
uniprot id: A0A8J0T2R3
uniprot id: A0A8J1JIR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

8364:lin52
gene id: 8364:lin52
uniprot id: A0A8J0SVL2
uniprot id: A9UMU3
names: Similarity
messages: Belongs to the lin-52 family.

8364:slc4a7
gene id: 8364:slc4a7
uniprot id: A0A6I8Q3V0
uniprot id: A0A6I8SE97
uniprot id: A0A6I8T241
uniprot id: A0A7D9NL69
uniprot id: A0A8J0SH87
uniprot id: A0A8J0SP86
uniprot id: A0A8J1JPG7
uniprot id: A0A8J1JPG9
uniprot id: A0A8J1JPH2
uniprot id: A0A8J1JPH4
uniprot id: A0A8J1JRZ9
uniprot id: A0A8J1JT76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

8364:LOC116411054
gene id: 8364:LOC116411054
uniprot id: A0A8J1JLD8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:c2orf69
gene id: 8364:c2orf69
uniprot id: F7E4J1
names: Similarity
messages: Belongs to the OSBP family.

8364:cryba4
gene id: 8364:cryba4
uniprot id: A4IH28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.
messages: Monomer.

8364:entpd4
gene id: 8364:entpd4
uniprot id: A0A6I8PVI8
uniprot id: A4IIR5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

8364:stx5
gene id: 8364:stx5
uniprot id: F6YKR5
uniprot id: Q66K93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

8364:smc1b
gene id: 8364:smc1b
uniprot id: A0A803K4U6
uniprot id: A0A8J0QGL9
uniprot id: A0A8J1J6K8
uniprot id: B1H2G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

8364:mymk
gene id: 8364:mymk
uniprot id: A0A803J6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

8364:hspa1b
gene id: 8364:hspa1b
uniprot id: A0A8J0QQQ6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8364:LOC108648246
gene id: 8364:LOC108648246
uniprot id: A0A8J0SVW4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:yae1
gene id: 8364:yae1
uniprot id: Q28GE6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8364:tlcd4
gene id: 8364:tlcd4
uniprot id: A0A6I8QGE6
uniprot id: A0A803J7W6
names: Subcellular Location Annotation
messages: Membrane

8364:LOC100497655
gene id: 8364:LOC100497655
uniprot id: A0A8J0QQR2
names: Similarity
messages: Belongs to the cyclin family.

8364:nkx2-5
gene id: 8364:nkx2-5
uniprot id: B1H1A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

8364:tubgcp3
gene id: 8364:tubgcp3
uniprot id: A0A8J0SBE2
uniprot id: F6YJC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

8364:macf1
gene id: 8364:macf1
uniprot id: A0A8J0QWE7
uniprot id: A0A8J0S871
uniprot id: A0A8J0SDG5
uniprot id: A0A8J0SFA4
uniprot id: A0A8J0SFA9
uniprot id: A0A8J0SGD7
uniprot id: A0A8J0SGF8
uniprot id: A0A8J0SGG4
uniprot id: A0A8J1J4I4
uniprot id: A0A8J1J4I9
uniprot id: A0A8J1J4J4
uniprot id: A0A8J1J4J6
uniprot id: A0A8J1J4J9
uniprot id: A0A8J1J4K0
uniprot id: A0A8J1J4K3
uniprot id: A0A8J1J4K4
uniprot id: A0A8J1J4K8
uniprot id: A0A8J1J4K9
uniprot id: A0A8J1J6Z1
uniprot id: A0A8J1J6Z7
uniprot id: A0A8J1J704
uniprot id: A0A8J1J7Z8
uniprot id: A0A8J1J804
uniprot id: A0A8J1J809
names: Subcellular Location Annotation
messages: cytoskeleton

8364:rbp4l
gene id: 8364:rbp4l
uniprot id: A4IGI2
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8364:pnpla6
gene id: 8364:pnpla6
uniprot id: A0A8J0Q6P1
uniprot id: A1L1E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8364:fcho2
gene id: 8364:fcho2
uniprot id: B4F6U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

8364:c1s
gene id: 8364:c1s
uniprot id: A0A803KFI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC100493706
gene id: 8364:LOC100493706
uniprot id: A0A6I8SFV2
uniprot id: F7EU05
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:KEG17 p07
gene id: 8364:KEG17_p07
uniprot id: Q5G7I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

8364:cops3
gene id: 8364:cops3
uniprot id: Q28IV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN3 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Nucleus

8364:h3-3a
gene id: 8364:h3-3a
uniprot id: A9JTR4
uniprot id: Q6P823
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with zmynd11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains.
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

8364:grem1
gene id: 8364:grem1
uniprot id: F7BL17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

8364:glra1
gene id: 8364:glra1
uniprot id: A0A803J6E5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

8364:zdhhc17
gene id: 8364:zdhhc17
uniprot id: A0A8J0QRH5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8364:cxcr2
gene id: 8364:cxcr2
uniprot id: A0A803JHD4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:farsa
gene id: 8364:farsa
uniprot id: A0A8J0SBK3
uniprot id: A0A8J0SC96
uniprot id: Q0D2F0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

8364:pcbp3
gene id: 8364:pcbp3
uniprot id: F7BN26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8364:erc1
gene id: 8364:erc1
uniprot id: A0A6I8Q514
uniprot id: A0A803KFP3
uniprot id: A0A8J1J6I6
uniprot id: A0A8J1J6I7
uniprot id: A0A8J1J6J1
uniprot id: A0A8J1J6J3
uniprot id: A0A8J1J6J5
uniprot id: A0A8J1J6J8
uniprot id: A0A8J1J8Y7
uniprot id: A0A8J1J8Z2
uniprot id: A0A8J1J9Z9
uniprot id: A0A8J1JA03
uniprot id: A0A8J1JA08
uniprot id: B0JZF9
uniprot id: F7DHL0
names: Subcellular Location Annotation
messages: Cytoplasm

8364:c10orf90
gene id: 8364:c10orf90
uniprot id: A0A6I8SAA1
names: Subcellular Location Annotation
messages: centrosome

8364:LOC108645658
gene id: 8364:LOC108645658
uniprot id: A0A8J0T188
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:megf10
gene id: 8364:megf10
uniprot id: A0A6I8R421
uniprot id: A0JM12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MEGF family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane receptor involved in phagocytosis. May also regulate homotypic retinal neuron repulsion. May play role in cell adhesion and motility. May also be an essential factor in the regulation of myogenesis, controlling the balance between skeletal muscle satellite cells proliferation and differentiation (By similarity).

8364:qars1
gene id: 8364:qars1
uniprot id: A0A6I8PWQ6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:snrpe
gene id: 8364:snrpe
uniprot id: Q6AZK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

8364:LOC100491742
gene id: 8364:LOC100491742
uniprot id: A0A1B8Y7U9
uniprot id: A0A803JQT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

8364:mon1a
gene id: 8364:mon1a
uniprot id: F6XF57
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

8364:grik4
gene id: 8364:grik4
uniprot id: A0A6I8RC42
uniprot id: A0A6I8SET0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:LOC100493299
gene id: 8364:LOC100493299
uniprot id: F6SU87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8364:LOC105945325
gene id: 8364:LOC105945325
uniprot id: A0A8J0S9U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100491743
gene id: 8364:LOC100491743
uniprot id: A0A6I8PJ95
uniprot id: A0A8J1JKB6
names: Subcellular Location Annotation
messages: Nucleus

8364:LOC100498066
gene id: 8364:LOC100498066
uniprot id: A0A8J0SYU7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8364:elmo2
gene id: 8364:elmo2
uniprot id: A0A6I8S2K7
uniprot id: A0A8J1IZJ4
uniprot id: Q66IJ1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

8364:rrp15
gene id: 8364:rrp15
uniprot id: A0A803JV35
names: Similarity
messages: Belongs to the RRP15 family.

8364:agpat5
gene id: 8364:agpat5
uniprot id: Q28E63
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8364:pcnx1
gene id: 8364:pcnx1
uniprot id: A0A6I8S8W7
uniprot id: A0A6I8SA03
uniprot id: A0A8J0R4C7
uniprot id: A0A8J0R751
uniprot id: A0A8J0SWU7
uniprot id: A0A8J1IQP4
uniprot id: F6ZTM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

8364:LOC116412175
gene id: 8364:LOC116412175
uniprot id: A0A8J1JUW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:ptpa
gene id: 8364:ptpa
uniprot id: A0A6I8RJ60
uniprot id: A0A8J0QZ06
uniprot id: A0A8J0SWF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8364:sycp2
gene id: 8364:sycp2
uniprot id: A0A6I8PLR3
uniprot id: A0A8J1IXJ4
uniprot id: A0A8J1IXP2
uniprot id: A0A8J1IZZ6
uniprot id: A0A8J1J0R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYCP2 family.
messages: Nucleus

8364:gmpr
gene id: 8364:gmpr
uniprot id: A0A8J0SQ82
uniprot id: A9JRK1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:sfrp2
gene id: 8364:sfrp2
uniprot id: Q6P8B8
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:megf11
gene id: 8364:megf11
uniprot id: A0A6I8Q2F4
uniprot id: A0A8J0T1I8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:dysf
gene id: 8364:dysf
uniprot id: A0A8J1JZC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

8364:apool
gene id: 8364:apool
uniprot id: A0A803KLS9
uniprot id: F7B6V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

8364:daxx
gene id: 8364:daxx
uniprot id: F6RWB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

8364:nav2
gene id: 8364:nav2
uniprot id: A0A8J1JDN9
uniprot id: A0A8J1JDP1
uniprot id: A0A8J1JDP2
uniprot id: A0A8J1JDP5
uniprot id: A0A8J1JDP6
uniprot id: A0A8J1JDP8
uniprot id: A0A8J1JDQ0
uniprot id: A0A8J1JDQ3
uniprot id: A0A8J1JDQ4
uniprot id: A0A8J1JDQ7
uniprot id: A0A8J1JDQ8
uniprot id: A0A8J1JG63
uniprot id: A0A8J1JG72
uniprot id: A0A8J1JG77
uniprot id: A0A8J1JH74
uniprot id: A0A8J1JH79
uniprot id: A0A8J1JH84
uniprot id: B3DLJ1
names: Similarity
messages: Belongs to the Nav/unc-53 family.

8364:papola
gene id: 8364:papola
uniprot id: A0A8J0SKB9
uniprot id: A0A8J0SSG7
uniprot id: B5DEV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

8364:rrm2b
gene id: 8364:rrm2b
uniprot id: F7BGD2
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

8364:casp9
gene id: 8364:casp9
uniprot id: A0A803JYQ8
uniprot id: B0JZV1
names: Similarity
messages: Belongs to the peptidase C14A family.

8364:gpld1
gene id: 8364:gpld1
uniprot id: A0A6I8RGD0
uniprot id: A0A8J1JUP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

8364:LOC113455423
gene id: 8364:LOC113455423
uniprot id: A0A8J0QHA2
names: Similarity
messages: Belongs to the MHC class I family.

8364:etnppl
gene id: 8364:etnppl
uniprot id: A4IHZ6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

8364:slain2
gene id: 8364:slain2
uniprot id: A0A6I8S5Z2
uniprot id: A0A7D9NLB8
uniprot id: A0A8J0R0G3
uniprot id: A0A8J1J083
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

8364:aatf
gene id: 8364:aatf
uniprot id: B2GUI4
names: Similarity
messages: Belongs to the AATF family.

8364:LOC101733812
gene id: 8364:LOC101733812
uniprot id: A0A6I8SZ67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

8364:hoxb5
gene id: 8364:hoxb5
uniprot id: F6Q943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8364:LOC116410971
gene id: 8364:LOC116410971
uniprot id: A0A8J1JPN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

8364:rbbp8
gene id: 8364:rbbp8
uniprot id: A0A6I8PUS5
uniprot id: A0A6I8SXZ9
uniprot id: A0A8J1JNB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

8364:LOC116407585
gene id: 8364:LOC116407585
uniprot id: Q28D68
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:npbwr1
gene id: 8364:npbwr1
uniprot id: F6U6V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC100492137
gene id: 8364:LOC100492137
uniprot id: A0A8J0SK03
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:krt62
gene id: 8364:krt62
uniprot id: A0A6I8QYX0
uniprot id: A0A8J0QNB3
names: Similarity
messages: Belongs to the intermediate filament family.

8364:galc
gene id: 8364:galc
uniprot id: A0A6I8QBD8
uniprot id: Q0VA39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 59 family.
messages: Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine.
messages: Lysosome

8364:LOC100490813
gene id: 8364:LOC100490813
uniprot id: A0A8J0QP59
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:inpp4b
gene id: 8364:inpp4b
uniprot id: A0A8J1J0J3
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

8364:tdrd3
gene id: 8364:tdrd3
uniprot id: A0A8J1J1E9
uniprot id: Q6P1U3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of mRNA stress granules.
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By similarity).
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
messages: The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 'Arg-17' (H3R17me2a) and histones H4 'Arg-3', 2 tags for epigenetic transcriptional activation.

8364:LOC100492634
gene id: 8364:LOC100492634
uniprot id: A0A8J0T351
names: Similarity
messages: Belongs to the peptidase C1 family.

8364:med26
gene id: 8364:med26
uniprot id: F6REY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 26 family.
messages: Nucleus

8364:cript
gene id: 8364:cript
uniprot id: F7CUQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

8364:LOC100494352
gene id: 8364:LOC100494352
uniprot id: A0A8J1JL28
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8364:miga2
gene id: 8364:miga2
uniprot id: F7ADT9
names: Similarity
messages: Belongs to the mitoguardin family.

8364:gsto1
gene id: 8364:gsto1
uniprot id: Q5PPQ3
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

8364:gjb1
gene id: 8364:gjb1
uniprot id: Q6NVT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:rmi1
gene id: 8364:rmi1
uniprot id: F6T588
uniprot id: F7CSK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Belongs to the WAL family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

8364:slc9a9
gene id: 8364:slc9a9
uniprot id: A0A803JEY2
uniprot id: A0A8J1JML7
uniprot id: F6RC40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

8364:t2r21
gene id: 8364:t2r21
uniprot id: Q2AB62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:nudt12
gene id: 8364:nudt12
uniprot id: F6VD39
uniprot id: F6Z3U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome

8364:LOC116408624
gene id: 8364:LOC116408624
uniprot id: A0A8J1J543
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC100495404
gene id: 8364:LOC100495404
uniprot id: A0A8J1JLD3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:reep2
gene id: 8364:reep2
uniprot id: A0A5K1UQR0
uniprot id: A0A8J0S8S4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:rpl37a
gene id: 8364:rpl37a
uniprot id: Q6AZL0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

8364:znf830
gene id: 8364:znf830
uniprot id: A0A1B8Y9X4
uniprot id: A0A8J0SPG3
uniprot id: Q6DJ13
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: May act as an important regulator of the cell cycle that participates in the maintenance of genome integrity.
messages: Nucleus
messages: Nucleus speckle

8364:camk1d
gene id: 8364:camk1d
uniprot id: A0A6I8QIV0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:nphs2
gene id: 8364:nphs2
uniprot id: A0A6I8PR56
uniprot id: F6THB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Belongs to the band 7/mec-2 family.
messages: Cytoplasm
messages: Nucleus

8364:mcoln2
gene id: 8364:mcoln2
uniprot id: A0A8J0QK14
uniprot id: A0A8J0SKY5
uniprot id: A0A8J1JI30
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

8364:borcs5
gene id: 8364:borcs5
uniprot id: A0A1B8Y9B6
uniprot id: A8E5U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

8364:sh3rf1
gene id: 8364:sh3rf1
uniprot id: A0A5S6KPN6
uniprot id: B7ZTV8
uniprot id: F6TM25
uniprot id: Q28E95
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autoubiquitinated. Ubiquitinated by SH3RF2, leading to proteasome-mediated degradation.
messages: Belongs to the SH3RF family.
messages: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway.
messages: The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

8364:LOC101730483
gene id: 8364:LOC101730483
uniprot id: A0A8J0SXF2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:gli3
gene id: 8364:gli3
uniprot id: A0A803JRJ1
uniprot id: A0A8J0SRT6
uniprot id: F6XFR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus

8364:shroom3
gene id: 8364:shroom3
uniprot id: A0A8J1JS53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

8364:LOC116408617
gene id: 8364:LOC116408617
uniprot id: A0A8J1J639
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:LOC116407569
gene id: 8364:LOC116407569
uniprot id: A0A803JHR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:xpr1
gene id: 8364:xpr1
uniprot id: Q28CY9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Cell membrane
messages: Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.
messages: The SPX domain has high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5-diphospho-myo-inositol pentakisphosphate (5-InsP7). Its affinity for inorganic phosphate is tow to three orders of magnitude lower.

8364:LOC101732209
gene id: 8364:LOC101732209
uniprot id: A0A8J1IV70
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:ggps1
gene id: 8364:ggps1
uniprot id: Q28GZ4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

8364:csk
gene id: 8364:csk
uniprot id: B5DDX0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8364:or52k1
gene id: 8364:or52k1
uniprot id: A0A8J0QW35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:irx3
gene id: 8364:irx3
uniprot id: Q6NVN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Both up-regulates and down-regulates gene expression during neural development. Acts early in neural plate development to induce proneural gene expression and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros.
messages: Belongs to the TALE/IRO homeobox family.
messages: Expressed in the neural plate in overlapping patterns with other irx members, which all share an anterior border of expression. Outside the nervous system and at tailbud stages, expressed in the developing otic vesicle, branchial arches, prospective heart region and pronephros.
messages: Nucleus

8364:LOC100496848
gene id: 8364:LOC100496848
uniprot id: A0A8J1IPU1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:sema4b
gene id: 8364:sema4b
uniprot id: A0A6I8RU83
uniprot id: A0A8J0T1Y9
uniprot id: A0A8J1JDK3
uniprot id: F6RW76
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:stxbp3
gene id: 8364:stxbp3
uniprot id: Q28E93
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

8364:LOC100494358
gene id: 8364:LOC100494358
uniprot id: F6R811
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

8364:LOC100489390
gene id: 8364:LOC100489390
uniprot id: A0A8J0SH96
names: Subcellular Location Annotation
messages: Membrane

8364:gask1a
gene id: 8364:gask1a
uniprot id: A0A6I8SQT7
names: Similarity
messages: Belongs to the GASK family.

8364:fam171a1
gene id: 8364:fam171a1
uniprot id: F7BD03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

8364:LOC108648803
gene id: 8364:LOC108648803
uniprot id: A0A8J0SWS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:khdc4
gene id: 8364:khdc4
uniprot id: A0A8J0SXS1
uniprot id: A0JM64
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KHDC4 family.
messages: Cytoplasm
messages: Interacts with PRPF19.
messages: Nucleus
messages: RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
messages: The C-terminal part is necessary for the interaction with the PRP19C/Prp19 complex/NTC/Nineteen complex.
messages: The KH domains mediate RNA-binding.

8364:tmem30b
gene id: 8364:tmem30b
uniprot id: Q28FC5
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

8364:pfkp
gene id: 8364:pfkp
uniprot id: A0A6I8Q4K8
uniprot id: A0A6I8SKY0
uniprot id: A0A8J0SFS1
uniprot id: A0A8J0SPB2
uniprot id: A0A8J0SQE5
uniprot id: A0A8J0SQF0
uniprot id: Q6P4Y8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:LOC101733670
gene id: 8364:LOC101733670
uniprot id: A0A1B8Y6X8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:foxq1
gene id: 8364:foxq1
uniprot id: A0A8J0QPT6
names: Subcellular Location Annotation
messages: Nucleus

8364:znf750
gene id: 8364:znf750
uniprot id: Q28BT7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor involved in epidermis differentiation.

8364:LOC101733770
gene id: 8364:LOC101733770
uniprot id: A0A8J1JUG8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:rbm8a
gene id: 8364:rbm8a
uniprot id: Q28BZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Part of the EJC core complex that contains casc3, eif4a3, magoh and rbm8a. Identified in the spliceosome C complex.
messages: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity).

8364:pou5f3.2
gene id: 8364:pou5f3.2
uniprot id: B3DM25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Interacts with components of the transcription complex that assembles on the vent2-B gene, including vent2 (via C-terminus), smad1 and smad4. Forms a repression complex on the promoters of the gsc and mix2 genes via interactions with the nodal/activin signaling pathway transducers foxh1/fast1, gtf2ird1/wbscr11 and smad2. Forms a repression complex on the promoters of the nodal/nr1 and siamois genes with the maternal factors tcf7l1/tcf3 and vegt (By similarity).
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Activates transcription when directly bound to the octamer DNA sequence, but can form repression complexes with other proteins at the promoter site to inhibit transcription. Binds to the promoter of the vent2-B gene to activate transcription when in the presence of other BMP signaling factors also bound to the promoter. Inhibits the competence of ectodermal cells to respond to BMP during embryogenesis thereby inhibiting epidermal differentiation and promoting neural induction. Antagonizes the activity of nodal/activin signaling by forming a transcriptional repression complex on the gsc and mix2 gene promoters to inhibit their transcription, and thus maintain the undifferentiated state of embryonic cells to prevent them from differentiating prematurely. Acts maternally to inhibit vegt and beta-catenin-activated gene transcription by forming a transcriptional repression complex on the nodal/nr1 and siamois promoters to inhibit their transcription (By similarity).

8364:thada
gene id: 8364:thada
uniprot id: A0A8J1JIP4
uniprot id: F7CI08
names: Similarity
messages: Belongs to the THADA family.

8364:ptgis
gene id: 8364:ptgis
uniprot id: A0A6I8RA65
uniprot id: A0A8J0R5J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

8364:dus4l
gene id: 8364:dus4l
uniprot id: A0A8J0T1H5
uniprot id: F7EI29
uniprot id: Q28G52
uniprot id: Q66KJ0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

8364:ilf3
gene id: 8364:ilf3
uniprot id: A0A6I8RWV8
uniprot id: A0A8J0S9V7
uniprot id: A0A8J0S9W1
uniprot id: A0A8J0SBG5
uniprot id: A0A8J0SCH5
uniprot id: Q6GL57
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A component of a ybx2/frgy2-containing mRNA-ribonucleoprotein (mRNP) complex. Also a component of the CCAAT box transcription factor (CBTF) complex.
messages: Cytoplasm
messages: Methylated by protein arginine N-methyltransferase 1 (prmt1b) in the RGG-rich domain. Methylation decreases DNA-binding and thereby decreases transcription of the gata2 gene, but does not regulate dsRNA binding or subcellular localization.
messages: Nucleus
messages: Phosphorylated. Phosphorylation affects nuclear translocation.
messages: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs. Has a cytoplasmic role early in development as part of a ribonucleoprotein (mRNP) complex which may regulate mRNA transport and/or translation. Following nuclear localization at the mid-blastula transition, acts as a transcription factor and binds the 5'-CCAAT-3' promoter sequence to regulate transcription of the gata2 gene as a subunit of the CCAAT box transcription factor (CBTF). Its role as an mRNP component negatively regulates its activity as a transcription factor by precluding its nuclear localization.

8364:gprin2
gene id: 8364:gprin2
uniprot id: A0A6I8RZ62
uniprot id: A0A8J1JVF2
names: Function
messages: May be involved in neurite outgrowth.

8364:myb
gene id: 8364:myb
uniprot id: A0A8J0R4S5
uniprot id: F6UI17
names: Subcellular Location Annotation
messages: Nucleus

8364:tuba1c
gene id: 8364:tuba1c
uniprot id: Q6P8G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8364:wars2
gene id: 8364:wars2
uniprot id: A0A1B8XUS2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8364:mbtd1
gene id: 8364:mbtd1
uniprot id: A0A6I8QVA8
uniprot id: A0A6I8RSH2
uniprot id: A0A8J0SWX1
uniprot id: A0A8J0SZC4
uniprot id: A0A8J0T015
uniprot id: A0A8J1IWC7
uniprot id: Q6DIN3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me. Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR).
messages: Chromosome
messages: Monomer. Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

8364:il2rb
gene id: 8364:il2rb
uniprot id: A0A803J3E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane

8364:umps
gene id: 8364:umps
uniprot id: A0A803J9F1
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

8364:tnfsf10
gene id: 8364:tnfsf10
uniprot id: A0A6I8PXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

8364:LOC100490052
gene id: 8364:LOC100490052
uniprot id: A0A6I8QRP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8364:fezf1
gene id: 8364:fezf1
uniprot id: Q0P4W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcription repressor. Involved in the development of the forebrain region (By similarity).

8364:LOC108648819
gene id: 8364:LOC108648819
uniprot id: A0A8J1IT36
names: Similarity
messages: Belongs to the ARTD/PARP family.

8364:mrpl41
gene id: 8364:mrpl41
uniprot id: A9ULK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

8364:pycr1
gene id: 8364:pycr1
uniprot id: Q28C85
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

8364:LOC100487852
gene id: 8364:LOC100487852
uniprot id: F7BYX9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:nsg2
gene id: 8364:nsg2
uniprot id: F6YM22
names: Similarity
messages: Belongs to the NSG family.

8364:LOC100495968
gene id: 8364:LOC100495968
uniprot id: A0A8J0QML7
uniprot id: A0A8J0R3P3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8364:tmem41a
gene id: 8364:tmem41a
uniprot id: A0A6I8PYM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

8364:ocm4.1
gene id: 8364:ocm4.1
uniprot id: Q5XH89
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8364:mycbp2
gene id: 8364:mycbp2
uniprot id: A0A8J1J4X1
uniprot id: A0A8J1J4X7
uniprot id: A0A8J1J4Y1
uniprot id: A0A8J1J4Y2
uniprot id: A0A8J1J4Y3
uniprot id: A0A8J1J4Y6
uniprot id: A0A8J1J4Y8
uniprot id: A0A8J1J4Y9
uniprot id: A0A8J1J4Z1
uniprot id: A0A8J1J4Z3
uniprot id: A0A8J1J4Z6
uniprot id: A0A8J1J4Z8
uniprot id: A0A8J1J502
uniprot id: A0A8J1J503
uniprot id: A0A8J1J7C9
uniprot id: A0A8J1J7D6
uniprot id: A0A8J1J7E3
uniprot id: A0A8J1J7E8
uniprot id: A0A8J1J8D1
uniprot id: A0A8J1J8D6
uniprot id: A0A8J1J8E1
uniprot id: A0A8J1J8E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RING-Cys relay (RCR) family.
messages: axon

8364:ghitm
gene id: 8364:ghitm
uniprot id: A0A8J0PJR2
uniprot id: F6ZFV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8364:LOC116406833
gene id: 8364:LOC116406833
uniprot id: A0A8J1IPX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:isoc2
gene id: 8364:isoc2
uniprot id: Q6DF67
names: Similarity
messages: Belongs to the isochorismatase family.

8364:epha2
gene id: 8364:epha2
uniprot id: Q6DII4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:LOC101734565
gene id: 8364:LOC101734565
uniprot id: A0A803JQK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8364:ppp1r32
gene id: 8364:ppp1r32
uniprot id: F6YVG9
names: Similarity
messages: Belongs to the GCF family.

8364:stk32a
gene id: 8364:stk32a
uniprot id: A0A6I8R893
names: Similarity
messages: Belongs to the protein kinase superfamily.

8364:LOC100494787
gene id: 8364:LOC100494787
uniprot id: A0A8J0SC57
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:crygdl.13
gene id: 8364:crygdl.13
uniprot id: A0A8J0QQC2
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:LOC100495470
gene id: 8364:LOC100495470
uniprot id: A0A8J1JEZ1
uniprot id: A0A8J1JEZ4
uniprot id: A0A8J1JEZ8
uniprot id: A0A8J1JHF1
uniprot id: A0A8J1JIF3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8364:pop5
gene id: 8364:pop5
uniprot id: A0A6I8PXL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

8364:mtx2
gene id: 8364:mtx2
uniprot id: A0A8J1IUL1
uniprot id: Q6GUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

8364:crygdl.11
gene id: 8364:crygdl.11
uniprot id: A0A8J0QK82
uniprot id: A0A8J0QP80
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8364:or12d3
gene id: 8364:or12d3
uniprot id: A0A8J0QYC3
names: Subcellular Location Annotation
messages: Membrane

8364:ms4a1
gene id: 8364:ms4a1
uniprot id: A0A8J0QT69
names: Similarity
messages: Belongs to the MS4A family.

8364:LOC116408386
gene id: 8364:LOC116408386
uniprot id: A0A8J1IZK0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:exoc7
gene id: 8364:exoc7
uniprot id: A0A6I8Q100
uniprot id: A0A6I8RLH7
uniprot id: A0A6I8SPG4
uniprot id: A0A8J1IWJ8
uniprot id: A0A8J1IWK0
uniprot id: A0A8J1IWK4
uniprot id: A0A8J1IWQ5
uniprot id: A0A8J1IZ02
uniprot id: A0A8J1IZ07
uniprot id: A0A8J1IZS3
uniprot id: B1H2K2
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

8364:phyhipl
gene id: 8364:phyhipl
uniprot id: A0A8J0SR45
uniprot id: Q0V9U8
names: Function
names: Similarity
messages: Belongs to the PHYHIP family.
messages: May play a role in the development of the central system.

8364:ebf2
gene id: 8364:ebf2
uniprot id: A0A6I8R0P0
uniprot id: A0A8J0SGV8
uniprot id: G1K3E3
uniprot id: Q6P4K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: May play a pivotal role in the transcriptional cascade that specifies primary neurons in embryos. Stabilizes the higher neural potential of selected progenitor cells that express neurog2/X-ngnr-1 by maintaining Delta-Notch signaling. Thus ensures the transition between neural competence and irreversible commitment to a neural fate. Also promotes neuronal differentiation by activating neurod1 expression, directly or indirectly (By similarity).
messages: Nucleus

8364:hmgcl
gene id: 8364:hmgcl
uniprot id: A0A8J0QPT9
uniprot id: A0A8J1JAS8
uniprot id: F6ZZ01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

8364:tac1
gene id: 8364:tac1
uniprot id: A0A1B8Y7B2
uniprot id: A0A803KFW2
uniprot id: A9JRI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

8364:ccdc85c
gene id: 8364:ccdc85c
uniprot id: A0A6I8R694
uniprot id: Q0V989
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity).
messages: adherens junction
messages: tight junction

8364:grin2d
gene id: 8364:grin2d
uniprot id: A0A8J1JX42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8364:kif21b
gene id: 8364:kif21b
uniprot id: A0A8J0QV67
uniprot id: A0A8J0QX95
uniprot id: A0A8J0QZF3
uniprot id: A0A8J0QZV4
uniprot id: A0A8J0SNZ6
uniprot id: A0A8J0SW07
uniprot id: A0A8J0SXW9
uniprot id: A0A8J0SZ45
uniprot id: A0A8J0SZ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

8364:sumo3
gene id: 8364:sumo3
uniprot id: Q6DK72
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with sae2 and ube2i. Covalently attached to a number of proteins (By similarity).
messages: PML body
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity).

8364:LOC101733656
gene id: 8364:LOC101733656
uniprot id: B0JZ06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:LOC108648862
gene id: 8364:LOC108648862
uniprot id: F7C6D9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8364:fshb
gene id: 8364:fshb
uniprot id: A0A803JNQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

8364:ncdn
gene id: 8364:ncdn
uniprot id: F6ZZX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

8364:hrh2
gene id: 8364:hrh2
uniprot id: A0A803JUZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:cwf19l1
gene id: 8364:cwf19l1
uniprot id: A0A6I8SHJ9
names: Similarity
messages: Belongs to the CWF19 family.

8364:msh4
gene id: 8364:msh4
uniprot id: A0A6I8R2E8
uniprot id: A0A8J1JI83
uniprot id: F7CER9
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

8364:bloc1s2
gene id: 8364:bloc1s2
uniprot id: Q66KB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S2 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. May also play a role in intracellular vesicle trafficking. As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
messages: Lysosome membrane
messages: centrosome

8364:ppp3cb
gene id: 8364:ppp3cb
uniprot id: A0A6I8Q966
uniprot id: A0A8J0SHC4
uniprot id: A2VCU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Cytoplasm

8364:t2r48
gene id: 8364:t2r48
uniprot id: Q2AB39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:atp2b1
gene id: 8364:atp2b1
uniprot id: A0A6I8RUQ4
uniprot id: A0A8J0QHC3
uniprot id: A0A8J0S8X9
uniprot id: A0A8J0SEN5
uniprot id: A0A8J1J9W2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:ptbp1
gene id: 8364:ptbp1
uniprot id: A0A8J0SJN1
uniprot id: Q5XGH0
names: Subcellular Location Annotation
messages: Nucleus

8364:csnk2b
gene id: 8364:csnk2b
uniprot id: Q6DEU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

8364:LOC100493023
gene id: 8364:LOC100493023
uniprot id: A0A8J1IPW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8364:opa3
gene id: 8364:opa3
uniprot id: F6V7L3
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

8364:LOC100496837
gene id: 8364:LOC100496837
uniprot id: A0A6I8Q7F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Membrane

8364:LOC101733075
gene id: 8364:LOC101733075
uniprot id: A0A8J1JVD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8364:c1orf43
gene id: 8364:c1orf43
uniprot id: B0BMK9
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

8364:pin4
gene id: 8364:pin4
uniprot id: Q6P4K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
messages: Cytoplasm
messages: May be involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to DNA (By similarity).
messages: nucleolus
messages: spindle

8364:otub1
gene id: 8364:otub1
uniprot id: A0A6I8Q9P2
names: Similarity
messages: Belongs to the peptidase C65 family.

8364:cebpz
gene id: 8364:cebpz
uniprot id: B2GUL8
names: Similarity
messages: Belongs to the CBF/MAK21 family.

8364:raly
gene id: 8364:raly
uniprot id: A0A8J0QMH3
uniprot id: F6RL63
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

8364:t2r34
gene id: 8364:t2r34
uniprot id: Q2AB51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8364:glg1
gene id: 8364:glg1
uniprot id: A0A6I8SB33
uniprot id: A0A8J0QHJ4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

8364:faslg
gene id: 8364:faslg
uniprot id: A0A6I8QWZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

8364:LOC100145331
gene id: 8364:LOC100145331
uniprot id: A0A6I8QM75
names: Similarity
messages: Belongs to the cytochrome P450 family.

8364:wrnip1
gene id: 8364:wrnip1
uniprot id: A0A6I8PTK5
uniprot id: B2GUI9
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

8364:pc.2
gene id: 8364:pc.2
uniprot id: A0A6I8SN43
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

8364:bcl2l11
gene id: 8364:bcl2l11
uniprot id: Q4KMV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Bcl-2 family.
messages: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.
messages: Induces apoptosis and anoikis.

8364:gtpbp8
gene id: 8364:gtpbp8
uniprot id: A0A6I8PV82
uniprot id: F7BCV5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8364:gtf2b
gene id: 8364:gtf2b
uniprot id: Q28G23
names: Similarity
messages: Belongs to the TFIIB family.

8364:LOC108645368
gene id: 8364:LOC108645368
uniprot id: A0A8J1JEL5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cytoskeleton

8364:LOC100495666
gene id: 8364:LOC100495666
uniprot id: A0A6I8RG80
uniprot id: A0A8J0QYV2
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8364:churc1
gene id: 8364:churc1
uniprot id: Q66JD9
names: Function
names: Similarity
messages: Belongs to the Churchill family.
messages: Transcriptional activator that mediates FGF signaling during neural development (By similarity). Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself (By similarity).

8364:rbp4
gene id: 8364:rbp4
uniprot id: F6UH11
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8364:lamtor5
gene id: 8364:lamtor5
uniprot id: A0A6I8R091
uniprot id: A9UL91
uniprot id: B7ZTQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMTOR5 family.
messages: Cytoplasm
messages: Lysosome
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity).

8364:smo
gene id: 8364:smo
uniprot id: A0A6I8RRT2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8364:krt78.3
gene id: 8364:krt78.3
uniprot id: A0A8J0QQK0
names: Similarity
messages: Belongs to the intermediate filament family.

8364:axl
gene id: 8364:axl
uniprot id: A0JP83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

8364:LOC100497241
gene id: 8364:LOC100497241
uniprot id: B0JZ06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.