8355:LOC121398910
gene id: 8355:LOC121398910
uniprot id: A0A8J1LZB2
names: Similarity
messages: Belongs to the cyclin family.

8355:p2rx5.L
gene id: 8355:p2rx5.L
uniprot id: A0A1L8HD30
uniprot id: A0A8J0UCH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8355:LOC108695576
gene id: 8355:LOC108695576
uniprot id: A0A1L8FQ74
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:camk4.S
gene id: 8355:camk4.S
uniprot id: A0A1L8HR34
uniprot id: A0A8J1M5P9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:pla2g1b.L
gene id: 8355:pla2g1b.L
uniprot id: A0A1L8I0B5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

8355:mc2r.L
gene id: 8355:mc2r.L
uniprot id: A0A1L8FYF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane

8355:mcm8.L
gene id: 8355:mcm8.L
uniprot id: A0A8J1KLP5
uniprot id: Q5F310
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MCM family.
messages: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart (By similarity). In eggs, required for elongation during DNA replication by facilitating the recruitment of rpa2/rpa34 and stimulating the processivity of DNA polymerases at replication foci. Probably not required for DNA replication in other cells.
messages: Component of the MCM8-MCM9 complex, which forms a hexamer composed of mcm8 and mcm9.
messages: Nucleus

8355:dlc1.S
gene id: 8355:dlc1.S
uniprot id: A0A8J1MQ09
uniprot id: Q6NRF8
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC121393061
gene id: 8355:LOC121393061
uniprot id: A0A8J1M4J7
names: Similarity
messages: Belongs to the FAM214 family.

8355:ucn3.S
gene id: 8355:ucn3.S
uniprot id: Q6E2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

8355:strip1.S
gene id: 8355:strip1.S
uniprot id: A0A8J1MAY9
uniprot id: A0A8J1MBA0
names: Similarity
messages: Belongs to the STRIP family.

8355:arvcf.L
gene id: 8355:arvcf.L
uniprot id: A0A8J0TVU5
uniprot id: A0A8J1LAV0
uniprot id: A0A8J1LB47
uniprot id: A0A8J1LB91
uniprot id: A0A8J1LBC4
uniprot id: A0A8J1LBP7
uniprot id: A0A8J1LBS5
uniprot id: A0A8J1LC07
uniprot id: A0A8J1LCS0
uniprot id: A0A8J1LD28
uniprot id: Q9DFB2
names: Similarity
messages: Belongs to the beta-catenin family.

8355:LOC108695879
gene id: 8355:LOC108695879
uniprot id: A0A8J0T6R7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:inpp5b.L
gene id: 8355:inpp5b.L
uniprot id: A0A1L8HFE6
uniprot id: A0A8J1M9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

8355:fbxl15.L
gene id: 8355:fbxl15.L
uniprot id: Q7SZ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBXL15 family.
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15).
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway). Required for dorsal/ventral pattern formation (By similarity.

8355:cfd.L
gene id: 8355:cfd.L
uniprot id: Q63ZK0
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: First expressed at the mid-neurula stage (stage 16) and remains at a constant level until the tadpole stage.
messages: In the embryo, localizes to paraxial regions at the neurula stage and anterior ventral regions at the tailbud stage. From the late tailbud to tadpole stage, expressed along the forming blood vessels including the anterior cardinal veins, posterior cardinal veins, intersomitic veins, dorsal longitudinal anastomosing vessel, dorsal aorta, pronephric sinus and most prominently around the vascular vitelline network, where expression shows left-right asymmetry in the stage 42 embryo. Localizes to endothelial cells. In adults, shows highest expression in liver with moderate levels of expression in the fat body, lung, gut and vessels. Weakly expressed in adult heart, muscle, testis and ovary.
messages: Probable serine protease.
messages: Secreted
messages: Was named 'ami' because of its expression pattern; 'ami' means 'mesh' or 'net' in Japanese.

8355:crisp1.5.S
gene id: 8355:crisp1.5.S
uniprot id: Q801Z0
names: Similarity
messages: Belongs to the CRISP family.

8355:noc2l.L
gene id: 8355:noc2l.L
uniprot id: A0A1L8FM05
names: Similarity
messages: Belongs to the NOC2 family.

8355:mea1.S
gene id: 8355:mea1.S
uniprot id: A0A1L8G0V5
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

8355:sema3e.L
gene id: 8355:sema3e.L
uniprot id: A0A8J1ML48
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:cav3.1.L
gene id: 8355:cav3.1.L
uniprot id: A0A1L8GPP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola
messages: sarcolemma

8355:usp13.S
gene id: 8355:usp13.S
uniprot id: A0A1L8G415
uniprot id: A0A8J0VG38
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:LOC121403059
gene id: 8355:LOC121403059
uniprot id: A0A8J1MY82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:xpa.L
gene id: 8355:xpa.L
uniprot id: A0A8J0TM34
uniprot id: P27088
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity).
messages: Nucleus

8355:chfr.S
gene id: 8355:chfr.S
uniprot id: A0A1L8HQH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHFR family.
messages: PML body

8355:ppp4r2.L
gene id: 8355:ppp4r2.L
uniprot id: Q5M7D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP4R2 family.
messages: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

8355:rpa1.S
gene id: 8355:rpa1.S
uniprot id: A0A8J1MD24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

8355:mst1r.L
gene id: 8355:mst1r.L
uniprot id: A0A8J1MTE7
uniprot id: A0A8J1MTL7
uniprot id: A0A8J1MUI0
uniprot id: A0A8J1MUU4
uniprot id: A0A8J1MVR6
uniprot id: P79950
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:LOC121402263
gene id: 8355:LOC121402263
uniprot id: A0A1L8G0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:slc26a7.L
gene id: 8355:slc26a7.L
uniprot id: A0A8J0VKG4
uniprot id: A0A8J1KYU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:lin28a.S
gene id: 8355:lin28a.S
uniprot id: A0A8J0UKS2
uniprot id: B7ZPW6
uniprot id: Q8JHC4
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-28 family.
messages: Cytoplasm
messages: Expressed from mid-gastrula to the tadpole stage. Appears to be largely absent from terminally differentiated cells of the adult.
messages: Monomer.
messages: P-body
messages: RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Suppressor of microRNA (miRNA) biogenesis, including that of let-7. Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).
messages: Rough endoplasmic reticulum
messages: Stress granule
messages: The CCHC zinc fingers interact with the GGAG motif at the 3' end of let-7 miRNAs precursors, more generally they bind the 5'-NGNNG-3' consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5' end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members (By similarity).
messages: nucleolus

8355:LOC108704859
gene id: 8355:LOC108704859
uniprot id: A0A8J1ML63
names: Similarity
messages: Belongs to the PDCD4 family.

8355:plbd2.L
gene id: 8355:plbd2.L
uniprot id: A0A1L8HZV9
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

8355:LOC108705673
gene id: 8355:LOC108705673
uniprot id: A0A310TM08
uniprot id: P06900
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-121 by BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated on Ser-15 during developmentally programmed apoptosis; which may facilitate apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:nlk.2.L
gene id: 8355:nlk.2.L
uniprot id: A0A8J1LTL4
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

8355:impa1.L
gene id: 8355:impa1.L
uniprot id: A0A8J0VH38
uniprot id: Q7SYT9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8355:LOC108715646
gene id: 8355:LOC108715646
uniprot id: A0A8J0V763
names: Subcellular Location Annotation
messages: Nucleus

8355:anapc1.S
gene id: 8355:anapc1.S
uniprot id: A0A1L8G1M8
uniprot id: A0A8J0VEN0
names: Similarity
messages: Belongs to the APC1 family.

8355:elovl2.S
gene id: 8355:elovl2.S
uniprot id: A0A8J0U413
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

8355:tek.S
gene id: 8355:tek.S
uniprot id: A0A1L8HP14
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:crygdl.14.L
gene id: 8355:crygdl.14.L
uniprot id: A0A8J1MF78
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:MGC82342
gene id: 8355:MGC82342
uniprot id: Q6INM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

8355:LOC108699581
gene id: 8355:LOC108699581
uniprot id: A0A8J0TNW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:pnck.S
gene id: 8355:pnck.S
uniprot id: A0A8J1LMI7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108717518
gene id: 8355:LOC108717518
uniprot id: A0A1L8G631
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:slc6a19.S
gene id: 8355:slc6a19.S
uniprot id: Q66J60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:LOC108695633
gene id: 8355:LOC108695633
uniprot id: A0A1L8HZH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:msra.1.L
gene id: 8355:msra.1.L
uniprot id: A0A1L8GCG0
uniprot id: A0A8J1KL22
uniprot id: Q7SZ81
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

8355:ccnyl1.S
gene id: 8355:ccnyl1.S
uniprot id: Q5U5D0
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

8355:oprm1.S
gene id: 8355:oprm1.S
uniprot id: A0A1L8G215
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

8355:LOC100036828
gene id: 8355:LOC100036828
uniprot id: A0A8J0Q480
uniprot id: A1A649
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:LOC108716297
gene id: 8355:LOC108716297
uniprot id: A0A8J1KR44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:kcna6.L
gene id: 8355:kcna6.L
uniprot id: A0A1L8GWF7
names: Subcellular Location Annotation
messages: Membrane

8355:slc2a6.L
gene id: 8355:slc2a6.L
uniprot id: A0A1L8F5Y6
uniprot id: Q66J34
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:angptl4.L
gene id: 8355:angptl4.L
uniprot id: A0A1L8HWP8
names: Subcellular Location Annotation
messages: Secreted

8355:epb41l5.L
gene id: 8355:epb41l5.L
uniprot id: A0A1L8EVD0
uniprot id: A0A8J0TTN7
uniprot id: A0A8J1LPG8
uniprot id: A0A8J1LQP3
uniprot id: Q7T0Z9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.

8355:sae1.L
gene id: 8355:sae1.L
uniprot id: A0A8J0TEN4
uniprot id: Q8JGT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of sae1 and uba2/sae2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with ube2i (By similarity).
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

8355:LOC108712923
gene id: 8355:LOC108712923
uniprot id: A0A8J0UWL1
uniprot id: A0A8J1MS08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8355:LOC108710495
gene id: 8355:LOC108710495
uniprot id: A0A1L8H418
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121399695
gene id: 8355:LOC121399695
uniprot id: A0A8J1M657
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108697863
gene id: 8355:LOC108697863
uniprot id: A0A8J1LE39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

8355:cnp.S
gene id: 8355:cnp.S
uniprot id: A0A1L8EKI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

8355:nbr1.L
gene id: 8355:nbr1.L
uniprot id: A0A8J0TSK2
uniprot id: A0A8J0TTL9
uniprot id: Q6PF38
names: Subcellular Location Annotation
messages: autophagosome

8355:psip1.L
gene id: 8355:psip1.L
uniprot id: A0A8J0UKR0
uniprot id: A0A8J0UKR5
uniprot id: Q5XXA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

8355:LOC108698841
gene id: 8355:LOC108698841
uniprot id: A0A1L8F5M6
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8355:celf3.S
gene id: 8355:celf3.S
uniprot id: A0A8J0TN94
uniprot id: Q7ZWM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein that may be involved in the regulation of pre-mRNA alternative splicing.

8355:LOC108707397
gene id: 8355:LOC108707397
uniprot id: A0A8J1M6T1
names: Similarity
messages: Belongs to the CD200R family.

8355:calhm6.L
gene id: 8355:calhm6.L
uniprot id: A0A1L8G8P4
uniprot id: A0A8J0Q576
uniprot id: A2RRX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

8355:LOC121393958
gene id: 8355:LOC121393958
uniprot id: A0A8J1KQZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108696410
gene id: 8355:LOC108696410
uniprot id: A0A8J0TBP6
names: Similarity
messages: Belongs to the NXPE family.

8355:LOC108696779
gene id: 8355:LOC108696779
uniprot id: A0A1L8FNP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

8355:LOC121399762
gene id: 8355:LOC121399762
uniprot id: A0A8J1M6F3
names: Similarity
messages: Belongs to the potassium channel KCNE family.

8355:pip4p2.S
gene id: 8355:pip4p2.S
uniprot id: A0A1L8FTE1
uniprot id: A0A8J0T505
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

8355:LOC121400385
gene id: 8355:LOC121400385
uniprot id: A0A8J1MC04
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

8355:napepld.S
gene id: 8355:napepld.S
uniprot id: A9UMN9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

8355:LOC108710289
gene id: 8355:LOC108710289
uniprot id: A0A8J1MJ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:pdia6.S
gene id: 8355:pdia6.S
uniprot id: Q7ZWN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

8355:lmx1b.1.S
gene id: 8355:lmx1b.1.S
uniprot id: A0A8J0TL24
uniprot id: Q8UVR3
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By activin; retinoic acid (RA) inhibits this up-regulation. Expression in neurons is regulated by calcium (Ca2+) activity: the lower the activity, the larger the number of neurons showing expression.
messages: Expressed zygotically from stage 10.5. Expression is elevated between stages 12.5 and 14, and continues throughout neurulae, tailbud and swimming tadpole stages.
messages: Nucleus
messages: Required for early specification of the kidney glomus, lying upstream of wt1 in the pathway controlling glomus differentiation. The balance in levels and expression patterns of binding partners such as lhx1/lim-1 influences differentiation into glomus or tubule derivatives. Involved in specification of serotonergic neurons.
messages: Shows a temporal expression pattern in three main areas: neural, kidney and limbs. From stage 13 onwards, expressed in regions of the nervous system including the placodes and otic vesicles, eye, specific sets of neurons, and in discreet regions of the neural tube. From stage 13, also expressed in the presumptive pronephros, and from stage 27 expression is predominant in the capsule of the pronephric glomus. Also expressed in the developing forelimbs and hindlimbs. In metamorphosing tadpoles, expressed in the eye, brain, muscle and mesonephric kidney.

8355:LOC108706667
gene id: 8355:LOC108706667
uniprot id: A0A1L8HLS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8355:LOC108705147
gene id: 8355:LOC108705147
uniprot id: A0A8J0U6T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:MGC130950
gene id: 8355:MGC130950
uniprot id: Q2TAS8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

8355:LOC108702303
gene id: 8355:LOC108702303
uniprot id: A0A8J1LY33
uniprot id: A0A8J1LZD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

8355:slx4.L
gene id: 8355:slx4.L
uniprot id: A0A068EUV4
uniprot id: A0A1L8EYC9
uniprot id: A0A8J0TU46
names: Similarity
messages: Belongs to the SLX4 family.

8355:rps6ka3.S
gene id: 8355:rps6ka3.S
uniprot id: A0A8J1MDX5
uniprot id: A0A8J1MES2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8355:ndufab1.L
gene id: 8355:ndufab1.L
uniprot id: Q3B8C5
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

8355:dnajb14.S
gene id: 8355:dnajb14.S
uniprot id: Q7ZXQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining hspa8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of hspa8/Hsc70: together with dnajb12, acts as a chaperone that promotes maturation of potassium channels by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on hspa8/Hsc70, the process of oligomerization of channel subunits is independent of hspa8/Hsc70.
messages: Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
messages: Endoplasmic reticulum membrane

8355:was.S
gene id: 8355:was.S
uniprot id: A0A1L8F463
uniprot id: A0A8J0TN11
uniprot id: A0A8J1LMJ3
uniprot id: A1L2K2
names: Subcellular Location Annotation
messages: Nucleus

8355:tmem59l.S
gene id: 8355:tmem59l.S
uniprot id: A0A1L8HNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:arl6ip4.L
gene id: 8355:arl6ip4.L
uniprot id: Q3KPW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: May be involved in modulating alternative pre-mRNA splicing.
messages: Nucleus speckle
messages: nucleolus

8355:rtraf.S
gene id: 8355:rtraf.S
uniprot id: A0A8J0TF02
uniprot id: Q5M9B0
names: Similarity
messages: Belongs to the RTRAF family.

8355:dus4l.L
gene id: 8355:dus4l.L
uniprot id: Q5EAZ1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

8355:metrnl.L
gene id: 8355:metrnl.L
uniprot id: A1L2K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the meteorin family.
messages: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance (By similarity).
messages: Secreted

8355:LOC108707607
gene id: 8355:LOC108707607
uniprot id: A0A8J1MAU2
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:LOC108710540
gene id: 8355:LOC108710540
uniprot id: A0A8J1MXB1
uniprot id: A0A8J1MY86
uniprot id: A0A8J1MYR5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:chek1.S
gene id: 8355:chek1.S
uniprot id: Q6DE87
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated through phosphorylation by atr or atm in response to DNA damage or inhibition of DNA replication.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Expressed throughout development. Transiently activated by ATR-mediated phosphorylation from the midblastula transition (MBT) to the initial gastrula stage. Developmentally regulated activation of the DNA replication checkpoint may occur as the nucleo-cytoplasmic ratio increases and maternal replication factors are depleted. Elongation of the embryonic cell cycle may allow time for the transcription of genes that initiate the switch from maternal to zygotic control of embryogenesis.
messages: Interacts with and phosphorylates clspn, an adapter protein that regulates the ATR-dependent phosphorylation of chek1.
messages: Nucleus
messages: Phosphorylated by atm in response to ionizing irradiation (By similarity). Phosphorylated by atr at Thr-314, Ser-344, Ser-356 and Ser-365 in response to various stimuli that cause checkpoint activation. Phosphorylation impairs binding of the C-terminal autoinhibitory region (AIR) to the kinase domain and thereby enhances kinase activity.
messages: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Phosphorylates wee1 at 'Ser-549' and cdc25c at 'Ser-287', which creates binding sites for 14-3-3 proteins which activate wee1 and inhibit cdc25c. Phosphorylates cdc25a at 'Ser-504' which prevents the interaction of cdc25a with CDK2-cyclin E1, CDC2-cyclin A1 and CDC2-cyclin B1. This inhibitory effect does not require 14-3-3 protein binding. Activation of wee1 and inhibition of CDC25 results in increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and consequent inhibition of cell cycle progression. May promote DNA repair, regulate chromatin assembly and the transcription of genes that regulate cell-cycle progression. May also play a role in replication fork maintenance.
messages: The autoinhibitory region (AIR) binds to the kinase domain and inhibits its activity.
messages: centrosome

8355:kmt5a.S
gene id: 8355:kmt5a.S
uniprot id: A0A8J0TPU6
uniprot id: Q08AY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
messages: Chromosome
messages: Nucleus
messages: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis.

8355:LOC108719445
gene id: 8355:LOC108719445
uniprot id: A0A8J1KZ74
uniprot id: A0A8J1KZ80
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

8355:clic4.S
gene id: 8355:clic4.S
uniprot id: Q6GQF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

8355:sumo2.L
gene id: 8355:sumo2.L
uniprot id: Q7ZTK7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Interacts with sae2 and ube2i. Covalently attached to a number of proteins, including top2.
messages: Nucleus
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

8355:LOC108716294
gene id: 8355:LOC108716294
uniprot id: A0A8J0V5Y3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:srp19.S
gene id: 8355:srp19.S
uniprot id: A0A1L8HR28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

8355:LOC108713902
gene id: 8355:LOC108713902
uniprot id: A0A8J0UZR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:cdc20.S
gene id: 8355:cdc20.S
uniprot id: Q8AVG7
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

8355:slc35e1.L
gene id: 8355:slc35e1.L
uniprot id: A0A1L8HXR5
uniprot id: Q6DDX2
names: Subcellular Location Annotation
messages: Membrane

8355:ip6k2.L
gene id: 8355:ip6k2.L
uniprot id: Q7T0Q8
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8355:appl1.L
gene id: 8355:appl1.L
uniprot id: Q6P9I3
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

8355:oxtr.S
gene id: 8355:oxtr.S
uniprot id: A0A1L8GHK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:pdcd10.L
gene id: 8355:pdcd10.L
uniprot id: A0A1L8GA63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

8355:aqp3.S
gene id: 8355:aqp3.S
uniprot id: Q9YH65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

8355:prep.S
gene id: 8355:prep.S
uniprot id: A0A1L8G2Y9
names: Similarity
messages: Belongs to the peptidase S9A family.

8355:XB5761341.S
gene id: 8355:XB5761341.S
uniprot id: A0A8J1N0Z6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:akr1c2.L
gene id: 8355:akr1c2.L
uniprot id: Q7ZXN5
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8355:LOC108695656
gene id: 8355:LOC108695656
uniprot id: A0A8J0SZD6
names: Subcellular Location Annotation
messages: Membrane

8355:lmf2.L
gene id: 8355:lmf2.L
uniprot id: Q7ZWN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.

8355:kcnj10.S
gene id: 8355:kcnj10.S
uniprot id: A0A1L8F5D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

8355:cacng1.S
gene id: 8355:cacng1.S
uniprot id: A0A1L8ENA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

8355:ago4.L
gene id: 8355:ago4.L
uniprot id: A0A8J1M5R8
uniprot id: A0A8J1M6U0
uniprot id: Q4KLV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family. Ago subfamily.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

8355:pds5b.L
gene id: 8355:pds5b.L
uniprot id: Q498H0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDS5 family.
messages: Interacts with the cohesin complex.
messages: Nucleus
messages: Phosphorylated in mitotic cells.
messages: Plays a role in androgen-induced proliferative arrest (By similarity). Required for maintenance of sister chromatid cohesion during mitosis.

8355:cacng8.L
gene id: 8355:cacng8.L
uniprot id: A0A8J0T3L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.

8355:atp6v1e1.L
gene id: 8355:atp6v1e1.L
uniprot id: Q7SZ08
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

8355:LOC121396266
gene id: 8355:LOC121396266
uniprot id: A0A8J1LDE7
uniprot id: A0A8J1LEB2
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:aldoc.L
gene id: 8355:aldoc.L
uniprot id: Q9PSX0
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

8355:gpat3.L
gene id: 8355:gpat3.L
uniprot id: Q68F37
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Protects cells against lipotoxicity.
messages: Endoplasmic reticulum membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

8355:LOC108699573
gene id: 8355:LOC108699573
uniprot id: A0A1L8FBQ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

8355:grid2.S
gene id: 8355:grid2.S
uniprot id: A0A8J1MY68
uniprot id: A0A8J1MZN0
uniprot id: A0A8J1N0F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:XB5918805.L
gene id: 8355:XB5918805.L
uniprot id: A0A1L8F5J4
uniprot id: A0A8J0TI70
names: Subcellular Location Annotation
messages: Membrane

8355:nck1.L
gene id: 8355:nck1.L
uniprot id: P79956
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

8355:LOC108712381
gene id: 8355:LOC108712381
uniprot id: A0A1L8HWB3
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

8355:dctn6.L
gene id: 8355:dctn6.L
uniprot id: Q6IRC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

8355:pclaf.S
gene id: 8355:pclaf.S
uniprot id: Q5HZL4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with pcna.
messages: Nucleus
messages: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with pcna is disrupted, facilitating the interaction between monoubiquitinated pcna and the translesion DNA synthesis DNA polymerase eta (polh) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity).
messages: perinuclear region

8355:LOC121393702
gene id: 8355:LOC121393702
uniprot id: A0A8J1KRP4
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:LOC108695918
gene id: 8355:LOC108695918
uniprot id: A0A8J1L7T0
uniprot id: A0A8J1L9F2
uniprot id: A0A8J1LAC8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:LOC121393661
gene id: 8355:LOC121393661
uniprot id: A0A8J1KR27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:LOC108699090
gene id: 8355:LOC108699090
uniprot id: A0A1L8FC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108701370
gene id: 8355:LOC108701370
uniprot id: A0A1L8EWE8
names: Subcellular Location Annotation
messages: Nucleus

8355:dusp3.L
gene id: 8355:dusp3.L
uniprot id: A0A1L8ETC6
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

8355:LOC108710302
gene id: 8355:LOC108710302
uniprot id: A0A1L8H0Q2
uniprot id: A0A8J1MMS8
uniprot id: A0A8J1MMU2
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

8355:mrps30.S
gene id: 8355:mrps30.S
uniprot id: Q90Z99
names: Subcellular Location Annotation
messages: Mitochondrion

8355:rpl23a.S
gene id: 8355:rpl23a.S
uniprot id: Q66KX3
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

8355:LOC108704827
gene id: 8355:LOC108704827
uniprot id: A0A8J0U8C5
uniprot id: A0A8J1MYM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
messages: Membrane

8355:LOC108710315
gene id: 8355:LOC108710315
uniprot id: A0A8J1MJ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:LOC121394569
gene id: 8355:LOC121394569
uniprot id: A0A8J1KYV3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:slc7a6.L
gene id: 8355:slc7a6.L
uniprot id: A0A1L8GKF7
uniprot id: A0A8J0UYC0
uniprot id: A1L3M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids.
messages: Membrane

8355:LOC108707736
gene id: 8355:LOC108707736
uniprot id: A0A8J0UFQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

8355:atp6v1c2.S
gene id: 8355:atp6v1c2.S
uniprot id: A0A1L8G4Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

8355:LOC108708778
gene id: 8355:LOC108708778
uniprot id: A0A8J0UK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:eif2d.S
gene id: 8355:eif2d.S
uniprot id: A1L106
names: Similarity
messages: Belongs to the eIF2D family.

8355:pdcd11.L
gene id: 8355:pdcd11.L
uniprot id: B3DLK9
names: Subcellular Location Annotation
messages: nucleolus

8355:LOC108699931
gene id: 8355:LOC108699931
uniprot id: A0A1L8F190
names: Subcellular Location Annotation
messages: Nucleus

8355:acat1.L
gene id: 8355:acat1.L
uniprot id: Q6NU46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Homotetramer.
messages: Mitochondrion
messages: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.

8355:tmem80.L
gene id: 8355:tmem80.L
uniprot id: A0A1L8GJJ4
names: Subcellular Location Annotation
messages: Membrane

8355:prdm13.L
gene id: 8355:prdm13.L
uniprot id: A0A1L8G9I2
names: Subcellular Location Annotation
messages: Nucleus

8355:angptl4.S
gene id: 8355:angptl4.S
uniprot id: A0A1L8HNC6
names: Subcellular Location Annotation
messages: Secreted

8355:LOC108699315
gene id: 8355:LOC108699315
uniprot id: A0A8J0TJV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:crmp1.S
gene id: 8355:crmp1.S
uniprot id: A0A1L8HKV2
uniprot id: A0A8J0UAI0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

8355:LOC121398278
gene id: 8355:LOC121398278
uniprot id: A0A8J1LVZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108713107
gene id: 8355:LOC108713107
uniprot id: A0A8J0UXH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:LOC108710839
gene id: 8355:LOC108710839
uniprot id: A0A1L8GWV1
uniprot id: A0A8J1MJR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:eif4g2.S
gene id: 8355:eif4g2.S
uniprot id: A0A8J0V8B6
uniprot id: A9JR46
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

8355:taf9b.L
gene id: 8355:taf9b.L
uniprot id: Q641A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

8355:foxe1.S
gene id: 8355:foxe1.S
uniprot id: A0A1L8HNS4
names: Subcellular Location Annotation
messages: Nucleus

8355:pcbd1.L
gene id: 8355:pcbd1.L
uniprot id: A0A8J1L9Z8
uniprot id: A0A8J1LEG7
uniprot id: Q63ZS4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

8355:snx13.S
gene id: 8355:snx13.S
uniprot id: A0A1L8FR40
names: Similarity
messages: Belongs to the sorting nexin family.

8355:mettl27.L
gene id: 8355:mettl27.L
uniprot id: Q6NUE1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:fis1.L
gene id: 8355:fis1.L
uniprot id: A0A1L8H3X6
uniprot id: Q3B8D8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

8355:amt.L
gene id: 8355:amt.L
uniprot id: Q0IH11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

8355:LOC100037180
gene id: 8355:LOC100037180
uniprot id: A2VD75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

8355:LOC108720108
gene id: 8355:LOC108720108
uniprot id: A0A1L8FSC8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8355:rgma.L
gene id: 8355:rgma.L
uniprot id: A0A1L8H103
uniprot id: A0A8J0UN40
uniprot id: Q7ZXG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8355:uncx.L
gene id: 8355:uncx.L
uniprot id: Q7ZXS0
names: Subcellular Location Annotation
messages: Nucleus

8355:dydc1.L
gene id: 8355:dydc1.L
uniprot id: A3KNE0
names: Similarity
messages: Belongs to the dpy-30 family.

8355:LOC108695638
gene id: 8355:LOC108695638
uniprot id: A0A8J1MGL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

8355:psmc3.S
gene id: 8355:psmc3.S
uniprot id: Q7ZWL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

8355:ppil6.S
gene id: 8355:ppil6.S
uniprot id: A0A8J0VAN2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8355:sparc.S
gene id: 8355:sparc.S
uniprot id: Q7ZXF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

8355:arsl.L
gene id: 8355:arsl.L
uniprot id: A0A8J0U5Y1
uniprot id: A0A8J1M7P2
uniprot id: A0A8J1M7U8
uniprot id: A0A8J1M8S3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8355:LOC121397646
gene id: 8355:LOC121397646
uniprot id: A0A8J1LM86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108710413
gene id: 8355:LOC108710413
uniprot id: A0A8J0UP99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:copg1.S
gene id: 8355:copg1.S
uniprot id: A0A1L8GHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:XB5960368.L
gene id: 8355:XB5960368.L
uniprot id: A0A1L8F6M2
uniprot id: A0A8J0TIU3
uniprot id: A0A8J1LII8
names: Similarity
messages: Belongs to the EVA1 family.

8355:LOC121399810
gene id: 8355:LOC121399810
uniprot id: A0A8J1M704
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:hephl1.L
gene id: 8355:hephl1.L
uniprot id: A0A1L8HJC5
names: Similarity
messages: Belongs to the multicopper oxidase family.

8355:paqr9.S
gene id: 8355:paqr9.S
uniprot id: A0A1L8G4K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8355:ppdpf.S
gene id: 8355:ppdpf.S
uniprot id: Q8AVU0
names: Function
names: Similarity
messages: Belongs to the PPDPF family.
messages: Probable regulator of exocrine pancreas development.

8355:lum.L
gene id: 8355:lum.L
uniprot id: A0A1L8GYE1
uniprot id: Q7SYS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

8355:rpl12.S
gene id: 8355:rpl12.S
uniprot id: Q8AVW0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

8355:gprc5a.L
gene id: 8355:gprc5a.L
uniprot id: A0A1L8GNH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108711383
gene id: 8355:LOC108711383
uniprot id: A0A1L8HVV0
uniprot id: A0A8J1N041
uniprot id: A0A8J1N0T4
uniprot id: A0A8J1N0T8
uniprot id: A0A8J1N1K5
names: Subcellular Location Annotation
messages: Membrane

8355:ugdhl.L
gene id: 8355:ugdhl.L
uniprot id: A0A1L8GX33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

8355:hhip.L
gene id: 8355:hhip.L
uniprot id: Q69GM1
uniprot id: Q7ZWL5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108707811
gene id: 8355:LOC108707811
uniprot id: A0A8J0U521
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

8355:pabpc1l.S
gene id: 8355:pabpc1l.S
uniprot id: A0A8J1LVR8
uniprot id: A0A8J1LVU3
uniprot id: A0A8J1LX47
uniprot id: A0A8J1LXZ9
uniprot id: Q98SP8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds and protects the poly(A) tail of mRNA with or without an AU-rich element (ARE) and prevents mRNA deadenylation. Stimulates the translation of mRNAs to which it is bound during early development.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm
messages: Expressed in adult testis, but at a reduced level compared to oocytes.
messages: Interacts with dazl in an RNA-independent manner. The C-terminus can self-associate and also interact with the C-terminus of pabpc1, independently of RNA. RRM 1 and RRM 2 interact with both eif4g1 and paip1, and the C-terminus also interacts with paip1. Prior to oocyte maturation, found in a complex with dazl and pum2 proteins and spdy1 mRNA; pum2 dissociates from the complex during maturation. Interacts with the translation termination factor sup35/erf3.
messages: Predominant from the stage VI oocyte through to the neurula stage (30 hours embryo), with levels decreasing at the onset of zygotic transcription.

8355:sh2b3.S
gene id: 8355:sh2b3.S
uniprot id: A0A8J0U276
names: Similarity
messages: Belongs to the SH2B adapter family.

8355:atp2b1.S
gene id: 8355:atp2b1.S
uniprot id: A0A1L8GUR1
uniprot id: A0A8J0UXS3
uniprot id: A0A8J1MS29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:baz1a.S
gene id: 8355:baz1a.S
uniprot id: A0A1L8EZM3
names: Subcellular Location Annotation
messages: Nucleus

8355:c5orf22.L
gene id: 8355:c5orf22.L
uniprot id: A0A8J0VH75
uniprot id: A0A8J0VIE3
uniprot id: A0A8J1KVB6
uniprot id: A0A8J1KVC3
uniprot id: Q6PAE6
names: Similarity
messages: Belongs to the UPF0489 family.

8355:LOC108719159
gene id: 8355:LOC108719159
uniprot id: A0A8J1LB99
uniprot id: A0A8J1LCR5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108698472
gene id: 8355:LOC108698472
uniprot id: A0A1L8F7V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:tlr1.L
gene id: 8355:tlr1.L
uniprot id: A0A1L8HTQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:pick1.L
gene id: 8355:pick1.L
uniprot id: A0A8J0UZU0
uniprot id: A0A8J1MWK8
uniprot id: Q32NG7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

8355:LOC108702722
gene id: 8355:LOC108702722
uniprot id: A0A1L8EM88
uniprot id: A0A8J1M0L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

8355:LOC108717188
gene id: 8355:LOC108717188
uniprot id: A0A1L8GBE6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:pigf.L
gene id: 8355:pigf.L
uniprot id: A0A1L8G5Y6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108717978
gene id: 8355:LOC108717978
uniprot id: A0A1L8G353
uniprot id: A0A1L8G376
uniprot id: A0A8J1KTF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

8355:slc26a4.1.L
gene id: 8355:slc26a4.1.L
uniprot id: A0A8J1MI23
uniprot id: Q5JBS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

8355:nasp.L
gene id: 8355:nasp.L
uniprot id: A0A8J0UZI8
uniprot id: A0A8J0V3J4
uniprot id: Q2VPH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

8355:LOC121394454
gene id: 8355:LOC121394454
uniprot id: A0A8J1KW65
names: Subcellular Location Annotation
messages: Membrane

8355:XB5802829.L
gene id: 8355:XB5802829.L
uniprot id: A0A1L8HZX1
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

8355:plxnb3.S
gene id: 8355:plxnb3.S
uniprot id: A0A1L8F1R8
uniprot id: A0A8J0TMX8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:dock10.S
gene id: 8355:dock10.S
uniprot id: A0A8J0VIG8
uniprot id: A0A8J1KR31
uniprot id: A0A8J1KR52
uniprot id: A0A8J1KR58
uniprot id: A0A8J1KR59
uniprot id: A0A8J1KR63
uniprot id: A0A8J1KR73
uniprot id: A0A8J1KSQ6
uniprot id: A0A8J1KSR6
uniprot id: A0A8J1KU82
uniprot id: A0A8J1KU89
uniprot id: A0A8J1KU98
uniprot id: A8E5Y4
names: Similarity
messages: Belongs to the DOCK family.

8355:LOC121396432
gene id: 8355:LOC121396432
uniprot id: A0A310U8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

8355:ptpn4.S
gene id: 8355:ptpn4.S
uniprot id: A0A8J0TYY6
uniprot id: A0A8J1LY46
uniprot id: Q6NRP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

8355:gda.L
gene id: 8355:gda.L
uniprot id: Q641E7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

8355:LOC108701528
gene id: 8355:LOC108701528
uniprot id: A0A1L8EXP1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

8355:cyp2b6.L
gene id: 8355:cyp2b6.L
uniprot id: Q63ZI7
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:tada2b.S
gene id: 8355:tada2b.S
uniprot id: A0A1L8HKS3
names: Subcellular Location Annotation
messages: Nucleus

8355:smpx.L
gene id: 8355:smpx.L
uniprot id: Q90Z58
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

8355:lrp3.L
gene id: 8355:lrp3.L
uniprot id: A0A1L8GL96
uniprot id: A0A8J0V5J7
uniprot id: A0A8J1MXG1
uniprot id: A0A8J1MYS3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108699424
gene id: 8355:LOC108699424
uniprot id: A0A1L8FCL3
uniprot id: A0A8J0TNJ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108709161
gene id: 8355:LOC108709161
uniprot id: A0A1L8H4U6
uniprot id: A0A8J1MDU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8355:gabbr1.S
gene id: 8355:gabbr1.S
uniprot id: A0A1L8F3J3
uniprot id: A0A8J0TS04
uniprot id: A0A8J1LPJ1
uniprot id: A0A8J1LQY0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:arl2.L
gene id: 8355:arl2.L
uniprot id: Q5HZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

8355:nppa.S
gene id: 8355:nppa.S
uniprot id: Q0IH46
names: Subcellular Location Annotation
messages: Secreted

8355:coq6.S
gene id: 8355:coq6.S
uniprot id: A0A1L8F0Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

8355:ntn4.S
gene id: 8355:ntn4.S
uniprot id: A0A1L8GUI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:agbl1.S
gene id: 8355:agbl1.S
uniprot id: A0A8J0UWB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

8355:ccnk.S
gene id: 8355:ccnk.S
uniprot id: A0A1L8F070
names: Similarity
messages: Belongs to the cyclin family.

8355:adam11.L
gene id: 8355:adam11.L
uniprot id: A0A1L8ESA9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ribc2.L
gene id: 8355:ribc2.L
uniprot id: Q3B8I0
names: Similarity
messages: Belongs to the RIB43A family.

8355:LOC108707495
gene id: 8355:LOC108707495
uniprot id: A0A1L8HF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:LOC121397642
gene id: 8355:LOC121397642
uniprot id: A0A8J1LM81
names: Subcellular Location Annotation
messages: Membrane

8355:serpinc1.L
gene id: 8355:serpinc1.L
uniprot id: Q8UVS0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

8355:cryga.1.L
gene id: 8355:cryga.1.L
uniprot id: Q6DKC9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:kiz.S
gene id: 8355:kiz.S
uniprot id: A0A1L8G1N3
uniprot id: A0A8J0VEL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

8355:LOC108706858
gene id: 8355:LOC108706858
uniprot id: A0A8J0U8Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

8355:snrnp200.L
gene id: 8355:snrnp200.L
uniprot id: A0A8J1MMC2
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

8355:cfap157.L
gene id: 8355:cfap157.L
uniprot id: A0A1L8GL28
uniprot id: A0A8J0V1C1
names: Similarity
messages: Belongs to the CFAP157 family.

8355:LOC108701833
gene id: 8355:LOC108701833
uniprot id: A0A8J1LSF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:atp6v1c1.L
gene id: 8355:atp6v1c1.L
uniprot id: Q5XH14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits (By similarity).

8355:tmem241.L
gene id: 8355:tmem241.L
uniprot id: A1L3G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM241 family.
messages: Membrane

8355:prmt9.L
gene id: 8355:prmt9.L
uniprot id: A0JMU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
messages: Cytoplasm

8355:acta4.S
gene id: 8355:acta4.S
uniprot id: P04752
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Actins are highly conserved proteins that are involved in various types of cell motility.
messages: Belongs to the actin family.
messages: First expressed after neurulation (stage 18), and expressed throughout development.
messages: Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: PubMed:3172214 suggest that the sequences isolated in PubMed:3009830 (alpha3-II) and PubMed:3172214 (alpha3-I) may represent paralogous genes in tetraploid Xenopus laevis.
messages: Shows overlapping but distinct expression patterns with other actins. In tailbud embryos, expressed in embryonic muscle (myotomes). In adults, expressed exclusively in skeletal muscle.
messages: The cardiac versus skeletal expression patterns of actins are probably sequence-dependent; Xenopus cardiac actins contain a Glu at position 3 of the mature peptide, whereas skeletal actins contain an Asp at this position.
messages: Xenopus contains at least three sarcomeric alpha actin genes that are preferentially expressed in either heart or skeletal muscle. Due to the tetraploid nature of Xenopus laevis, each of these three alpha actin genes is present in at least two copies.
messages: cytoskeleton

8355:ndufs1.L
gene id: 8355:ndufs1.L
uniprot id: A0A8J0TIW2
uniprot id: Q802B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

8355:zc3h12a.L
gene id: 8355:zc3h12a.L
uniprot id: A0A1L8HFI5
names: Similarity
messages: Belongs to the ZC3H12 family.

8355:grk4.S
gene id: 8355:grk4.S
uniprot id: Q5XH04
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:LOC121401578
gene id: 8355:LOC121401578
uniprot id: A0A8J1MNA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:nme6.S
gene id: 8355:nme6.S
uniprot id: A0A8J1MRF7
names: Similarity
messages: Belongs to the NDK family.

8355:LOC108702210
gene id: 8355:LOC108702210
uniprot id: A0A8J1LXF6
uniprot id: A0A8J1LXG0
uniprot id: A0A8J1LXS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108704479
gene id: 8355:LOC108704479
uniprot id: A0A8J0U444
uniprot id: A0A8J0U5F2
uniprot id: A0A8J0U7J6
uniprot id: A0A8J1LHT5
uniprot id: A0A8J1LHU6
uniprot id: A0A8J1LHV1
uniprot id: A0A8J1LHW7
uniprot id: A0A8J1LHW9
uniprot id: A0A8J1LHX4
uniprot id: A0A8J1LHX9
uniprot id: A0A8J1LIG0
uniprot id: A0A8J1LIH1
uniprot id: A0A8J1LIH6
uniprot id: A0A8J1LJ65
uniprot id: A0A8J1LJ70
uniprot id: A0A8J1LJ75
uniprot id: A0A8J1LJ80
uniprot id: A0A8J1LKA8
uniprot id: A0A8J1LKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: cytoskeleton

8355:nbl1.S
gene id: 8355:nbl1.S
uniprot id: A0A1L8FHM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

8355:akt1.S
gene id: 8355:akt1.S
uniprot id: A0A1L8F033
uniprot id: Q98TY9
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: AKT1 is one of several closely related serine/threonine-protein kinases known as the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase (By similarity). Required for insulin-stimulated meiotic reinitiation during oocyte maturation.
messages: Activated in response to insulin. Three specific sites, one in the kinase domain (Thr-309) and the two other ones in the C-terminal regulatory region (Ser-474 and Tyr-475), need to be phosphorylated for its full activation.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
messages: Binding of the PH domain to phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) following phosphatidylinositol 3-kinase alpha (PIK3CA) activity results in its targeting to the plasma membrane.
messages: Cleavage by caspase-3/CASP3 (By similarity). Cleaved at the caspase-3 consensus site Asp-463 during apoptosis, resulting in down-regulation of the AKT signaling pathway and decreased cell survival (By similarity).
messages: Cytoplasm
messages: Expressed in the oocyte.
messages: Nucleus

8355:LOC121394485
gene id: 8355:LOC121394485
uniprot id: A0A1L8FYS4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:acad11.L
gene id: 8355:acad11.L
uniprot id: A0A8J0VNS8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8355:LOC108710516
gene id: 8355:LOC108710516
uniprot id: A0A8J0UN71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108706698
gene id: 8355:LOC108706698
uniprot id: A0A1L8HM06
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

8355:stim2.S
gene id: 8355:stim2.S
uniprot id: A0A1L8HKY4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:arpc2.L
gene id: 8355:arpc2.L
uniprot id: A0A8J0TK15
uniprot id: Q0IH88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

8355:LOC108710410
gene id: 8355:LOC108710410
uniprot id: A0A1L8H3J2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ctsb.L
gene id: 8355:ctsb.L
uniprot id: Q7ZWX2
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:homer2.S
gene id: 8355:homer2.S
uniprot id: A0A1L8GSV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

8355:orc4.L
gene id: 8355:orc4.L
uniprot id: Q3B8I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

8355:LOC108699034
gene id: 8355:LOC108699034
uniprot id: A0A8J0TJ05
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:borcs7.S
gene id: 8355:borcs7.S
uniprot id: A0A8J0T5U6
uniprot id: A0A8J0TDV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Membrane

8355:hadhb.L
gene id: 8355:hadhb.L
uniprot id: A0A1L8GCR3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

8355:LOC108703093
gene id: 8355:LOC108703093
uniprot id: A0A1L8EQ32
names: Similarity
messages: Belongs to the globin family.

8355:tnfrsf6b.S
gene id: 8355:tnfrsf6b.S
uniprot id: A0A1L8ELX1
uniprot id: A0A8J0U0J6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:slc10a4.S
gene id: 8355:slc10a4.S
uniprot id: A0A1L8HL48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

8355:LOC108705289
gene id: 8355:LOC108705289
uniprot id: A0A8J0U746
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:gng5.L
gene id: 8355:gng5.L
uniprot id: Q6GNC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:LOC108704416
gene id: 8355:LOC108704416
uniprot id: A0A8J0U593
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

8355:LOC121398106
gene id: 8355:LOC121398106
uniprot id: A0A8J1LU84
uniprot id: A0A8J1LV49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

8355:LOC108709461
gene id: 8355:LOC108709461
uniprot id: A0A1L8H766
names: Similarity
messages: Belongs to the MDFI family.

8355:LOC121393593
gene id: 8355:LOC121393593
uniprot id: A0A8J1KM31
names: Subcellular Location Annotation
messages: Membrane

8355:snx21.S
gene id: 8355:snx21.S
uniprot id: A0A1L8EMD2
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Membrane

8355:dram1.S
gene id: 8355:dram1.S
uniprot id: A0A1L8GUR9
names: Subcellular Location Annotation
messages: Membrane

8355:XB5907626.L
gene id: 8355:XB5907626.L
uniprot id: A0A310U9W1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8355:dnase2b.S
gene id: 8355:dnase2b.S
uniprot id: A0A1L8GFB9
names: Similarity
messages: Belongs to the DNase II family.

8355:cemip2.S
gene id: 8355:cemip2.S
uniprot id: A0A1L8HP57
names: Similarity
messages: Belongs to the CEMIP family.

8355:prrt2.L
gene id: 8355:prrt2.L
uniprot id: A0A8J1LRV6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:cyb5a.S
gene id: 8355:cyb5a.S
uniprot id: A0A1L8FSJ5
names: Similarity
messages: Belongs to the cytochrome b5 family.

8355:nosip.S
gene id: 8355:nosip.S
uniprot id: A0A1L8FGZ1
uniprot id: Q6NUH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity).
messages: Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity.
messages: Nucleus

8355:tmem182.L
gene id: 8355:tmem182.L
uniprot id: A0A8J0TKE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

8355:ntf4.S
gene id: 8355:ntf4.S
uniprot id: A0A8J1LDN6
names: Similarity
messages: Belongs to the NGF-beta family.

8355:LOC121400451
gene id: 8355:LOC121400451
uniprot id: A0A8J1MCS3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108698315
gene id: 8355:LOC108698315
uniprot id: A0A1L8F6Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane

8355:mns1.L
gene id: 8355:mns1.L
uniprot id: A0A1L8H0B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

8355:timp3.S
gene id: 8355:timp3.S
uniprot id: A0A1L8GQI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: extracellular matrix

8355:LOC121403042
gene id: 8355:LOC121403042
uniprot id: A0A1L8GLV2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

8355:LOC108697493
gene id: 8355:LOC108697493
uniprot id: A0A1L8FF43
uniprot id: A0A8J0T663
uniprot id: A0A8J0TC59
uniprot id: A0A8J0TE47
uniprot id: A0A8J0TE52
uniprot id: A0A8J0TE54
uniprot id: A0A8J0TEX5
uniprot id: A0A8J0TEY0
uniprot id: A0A8J0TFK7
uniprot id: A0A8J1LBX0
uniprot id: A0A8J1LDH0
uniprot id: O57682
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By activin. Weakly by bFGF.
messages: Expression becomes spatially localized at mid-gastrula stages and is localized to the nervous system (midbrain, hindbrain, spinal cord), sensory organs (optic vesicle and stalk, otic vesicle), visceral arches, developing excretory system (pronephros, pronephric duct, rectal diverticulum, proctodaeum) and thryoid gland. Splicing does not appear to be tissue-specific.
messages: Nucleus
messages: Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 in pronephric morphogenesis during the tailbud stages.
messages: Splicing is temporally regulated. Isoform 3 is expressed both maternally and zygotically, whereas isoform 2 is exclusively zygotic. Expression is highest in embryos from stage 12 on, with expression levels remaining constant throughout embryogenesis.

8355:nt5c2.S
gene id: 8355:nt5c2.S
uniprot id: A0A8J1LBG7
uniprot id: A0A8J1LBH6
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

8355:LOC108705353
gene id: 8355:LOC108705353
uniprot id: A0A8J1MYY9
names: Subcellular Location Annotation
messages: Nucleus

8355:tmem198.S
gene id: 8355:tmem198.S
uniprot id: A0A1L8H9P4
uniprot id: A0A1L8H9U0
uniprot id: Q66IY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

8355:rps27.L
gene id: 8355:rps27.L
uniprot id: A0A1L8EJM5
uniprot id: A0A8J1LKU3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

8355:leprot.L
gene id: 8355:leprot.L
uniprot id: Q66KQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

8355:cpt2.S
gene id: 8355:cpt2.S
uniprot id: Q7ZXE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.
messages: Mitochondrion inner membrane

8355:ap2s1.S
gene id: 8355:ap2s1.S
uniprot id: Q66L27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

8355:naaladl1.L
gene id: 8355:naaladl1.L
uniprot id: A0A1L8GJI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

8355:bloc1s2.L
gene id: 8355:bloc1s2.L
uniprot id: A1L2W6
names: Similarity
messages: Belongs to the BLOC1S2 family.

8355:nampt.S
gene id: 8355:nampt.S
uniprot id: A0A8J1MP05
uniprot id: Q6NRZ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

8355:slc25a46.S
gene id: 8355:slc25a46.S
uniprot id: Q6INQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.
messages: Mitochondrion outer membrane

8355:tubgcp3.S
gene id: 8355:tubgcp3.S
uniprot id: A0A8J0UHX5
uniprot id: Q6PF23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

8355:LOC108709791
gene id: 8355:LOC108709791
uniprot id: A0A1L8H9D9
uniprot id: A0A8J0ULG7
uniprot id: A0A8J1MGT8
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

8355:LOC108712615
gene id: 8355:LOC108712615
uniprot id: A0A8J1MQC3
uniprot id: A0A8J1MRD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

8355:mrpl12.L
gene id: 8355:mrpl12.L
uniprot id: Q5U556
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

8355:slc12a2.L
gene id: 8355:slc12a2.L
uniprot id: A0A1L8I1I1
uniprot id: A0A8J1M6H1
uniprot id: A9ZLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

8355:krt62.L
gene id: 8355:krt62.L
uniprot id: Q98UJ3
names: Similarity
messages: Belongs to the intermediate filament family.

8355:adgrl2.S
gene id: 8355:adgrl2.S
uniprot id: A0A1L8GFI9
uniprot id: A0A8J0V5U5
uniprot id: A0A8J0V6L9
uniprot id: A0A8J0VB76
uniprot id: A0A8J1KIP6
uniprot id: A0A8J1KIQ1
uniprot id: A0A8J1KIR3
uniprot id: A0A8J1KIR5
uniprot id: A0A8J1KIR8
uniprot id: A0A8J1KIS0
uniprot id: A0A8J1KIS4
uniprot id: A0A8J1KIS6
uniprot id: A0A8J1KIS8
uniprot id: A0A8J1KIT0
uniprot id: A0A8J1KIT2
uniprot id: A0A8J1KIT5
uniprot id: A0A8J1KIT8
uniprot id: A0A8J1KIU1
uniprot id: A0A8J1KIV1
uniprot id: A0A8J1KKF9
uniprot id: A0A8J1KKG2
uniprot id: A0A8J1KKG7
uniprot id: A0A8J1KKH2
uniprot id: A0A8J1KKH7
uniprot id: A0A8J1KKI3
uniprot id: A0A8J1KKI8
uniprot id: A0A8J1KLV4
uniprot id: A0A8J1KLV9
uniprot id: A0A8J1KLW5
uniprot id: A0A8J1KLX1
uniprot id: A0A8J1KLY4
uniprot id: A0A8J1KLZ0
names: Subcellular Location Annotation
messages: Membrane

8355:sirt5.L
gene id: 8355:sirt5.L
uniprot id: Q5HZN8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-101 and Arg-104) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
messages: Nucleus
messages: cytosol

8355:bcl2l10.L
gene id: 8355:bcl2l10.L
uniprot id: A0A1L8H0I4
names: Similarity
messages: Belongs to the Bcl-2 family.

8355:LOC108697325
gene id: 8355:LOC108697325
uniprot id: A0A8J1LCR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8355:ap2b1.L
gene id: 8355:ap2b1.L
uniprot id: A0A1L8HFX3
uniprot id: A0A8J0UBP0
uniprot id: A0A8J1M541
uniprot id: Q7ZYG7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

8355:tuba1cl.2.S
gene id: 8355:tuba1cl.2.S
uniprot id: A0A8J1LRK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8355:LOC108714854
gene id: 8355:LOC108714854
uniprot id: A0A1L8HYJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: May act as a transcriptional regulator of a number of proteins of the circadian clock.
messages: Nucleus

8355:rpl3.L
gene id: 8355:rpl3.L
uniprot id: Q7ZYR1
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

8355:atp13a5.L
gene id: 8355:atp13a5.L
uniprot id: A0A1L8GA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8355:tmprss2.9.L
gene id: 8355:tmprss2.9.L
uniprot id: A0A8J1M5Z5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:efcab7.L
gene id: 8355:efcab7.L
uniprot id: Q6DCF6
names: Function
names: Subcellular Location Annotation
messages: Plays a role in the ciliary Hedgehog (Hh) signaling.
messages: cilium membrane

8355:btbd6.L
gene id: 8355:btbd6.L
uniprot id: Q2LE78
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (PubMed:18855900).
messages: Cytoplasm
messages: Embryos show strong defects in late neuronal markers and strongly reduced and disorganized axons while early neural development is unaffected. Muscle development is also affected.
messages: Highly expressed in the developing nervous system.
messages: Homodimer and heterodimer. Interacts with cul3 via the BTB domain.

8355:naaal.L
gene id: 8355:naaal.L
uniprot id: Q6PCG3
names: Similarity
messages: Belongs to the acid ceramidase family.

8355:rffl.L
gene id: 8355:rffl.L
uniprot id: A0A1L8HG40
uniprot id: A0A8J0UCC9
uniprot id: Q68EY6
names: Subcellular Location Annotation
messages: Cell membrane

8355:LOC108716602
gene id: 8355:LOC108716602
uniprot id: A0A1L8G7G1
names: Subcellular Location Annotation
messages: Nucleus

8355:dolk.S
gene id: 8355:dolk.S
uniprot id: Q6GN28
names: Similarity
messages: Belongs to the polyprenol kinase family.

8355:tmem209.S
gene id: 8355:tmem209.S
uniprot id: Q6GPP7
names: Subcellular Location Annotation
messages: Membrane

8355:dntt.L
gene id: 8355:dntt.L
uniprot id: P42118
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DNA polymerase type-X family.
messages: Can also utilize other divalent cations, such as Mn(2+) and Co(2+) (in vitro).
messages: During ontogeny TDT appears in significant amounts in the thymus of tadpoles at metamorphic climax but little in the earlier midlarval stages.
messages: Found in the thymus and not in the spleen, kidney, intestine, or liver.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

8355:brinp1.L
gene id: 8355:brinp1.L
uniprot id: A0A1L8F6W0
names: Similarity
messages: Belongs to the BRINP family.

8355:pfkfb1.S
gene id: 8355:pfkfb1.S
uniprot id: A0A1L8F1P5
uniprot id: Q5PPL7
uniprot id: Q5U4Z6
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

8355:LOC108704298
gene id: 8355:LOC108704298
uniprot id: A0A1L8G0S1
uniprot id: P84233
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:ltv1.L
gene id: 8355:ltv1.L
uniprot id: Q4V838
names: Sequence Caution
names: Similarity
messages: Belongs to the LTV1 family.
messages: Contaminating sequence. Potential poly-A sequence.

8355:slc25a21.L
gene id: 8355:slc25a21.L
uniprot id: A0A1L8FAP4
uniprot id: A0A8J0THB6
uniprot id: Q0IHC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:gins1.S
gene id: 8355:gins1.S
uniprot id: Q7ZT47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of gins1/psf1, gins2/psf2, gins3/psf3 and gins4/sld5 (PubMed:12730133). Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45 (PubMed:30979826, PubMed:30842657).
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

8355:LOC108695826
gene id: 8355:LOC108695826
uniprot id: A0A8J1L856
names: Similarity
messages: Belongs to the NXPE family.

8355:eef1a1.L
gene id: 8355:eef1a1.L
uniprot id: A0A1L8G3E8
uniprot id: P13549
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3 EF-1-alpha are expressed under different developmental control in Xenopus laevis. This protein is expressed in embryos beginning at the mid-blastula transition and in adults cells.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8355:LOC121401268
gene id: 8355:LOC121401268
uniprot id: A0A8J1MJ67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:khdrbs1.L
gene id: 8355:khdrbs1.L
uniprot id: A0A8J1M8Q7
uniprot id: A0A8J1M8V9
names: Similarity
messages: Belongs to the KHDRBS family.

8355:serpinf2.L
gene id: 8355:serpinf2.L
uniprot id: A0A1L8HD88
uniprot id: A0A8J0U5S4
uniprot id: A0A8J0UCP7
uniprot id: A0A8J0UE28
names: Similarity
messages: Belongs to the serpin family.

8355:tgfbi.L
gene id: 8355:tgfbi.L
uniprot id: Q5PQ61
names: Subcellular Location Annotation
messages: extracellular matrix

8355:arih1.L
gene id: 8355:arih1.L
uniprot id: Q32NS4
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoinhibited by the ariadne domain, which masks the second RING-type zinc finger that contains the active site and inhibits the E3 activity. Inhibition is relieved upon binding to neddylated cullin-RING ubiquitin ligase complexes, which activate the E3 ligase activity of ARIH1.
messages: Belongs to the RBR family. Ariadne subfamily.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes.
messages: Interacts (via the first RING-type zinc finger) with ube2l3. Associates with cullin-RING ubiquitin ligase (CRL) complexes containing neddylated cullin.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.
messages: Nucleus
messages: The Ariadne domain inhibits activity by masking the second RING-type zinc finger that contains the active site.

8355:LOC108711451
gene id: 8355:LOC108711451
uniprot id: A0A8J0UKC6
uniprot id: A0A8J0UVS8
names: Similarity
messages: Belongs to the CEMIP family.

8355:ubiad1.L
gene id: 8355:ubiad1.L
uniprot id: A0A1L8FKW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

8355:reep3.S
gene id: 8355:reep3.S
uniprot id: A0A1L8FE65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

8355:gbx1.S
gene id: 8355:gbx1.S
uniprot id: A0A1L8FPV8
names: Subcellular Location Annotation
messages: Nucleus

8355:nkx2-1.L
gene id: 8355:nkx2-1.L
uniprot id: Q9DFG2
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108716536
gene id: 8355:LOC108716536
uniprot id: A0A8J0VB27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

8355:LOC108710593
gene id: 8355:LOC108710593
uniprot id: A0A1L8GZ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC108701244
gene id: 8355:LOC108701244
uniprot id: A0A8J0TM08
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:jup.L
gene id: 8355:jup.L
uniprot id: Q6NU15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Membrane
messages: desmosome

8355:LOC108707654
gene id: 8355:LOC108707654
uniprot id: A0A1L8HBY7
names: Similarity
messages: Belongs to the cystatin family.

8355:LOC108699264
gene id: 8355:LOC108699264
uniprot id: A0A8J1LIC6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108715399
gene id: 8355:LOC108715399
uniprot id: A0A1L8GEV8
names: Subcellular Location Annotation
messages: Membrane

8355:nptxr.L
gene id: 8355:nptxr.L
uniprot id: A0A8J0V304
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108708594
gene id: 8355:LOC108708594
uniprot id: A0A8J1MBM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:tmem63b.S
gene id: 8355:tmem63b.S
uniprot id: A0A1L8G0R7
uniprot id: A0A8J0VFC3
uniprot id: A0A8J0VJR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

8355:LOC121398067
gene id: 8355:LOC121398067
uniprot id: A0A310TTQ1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108711111
gene id: 8355:LOC108711111
uniprot id: A0A1L8GYM6
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

8355:nmnat2.L
gene id: 8355:nmnat2.L
uniprot id: A0A8J1MX41
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

8355:nceh1.L
gene id: 8355:nceh1.L
uniprot id: A0A1L8GA66
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

8355:deup1.L
gene id: 8355:deup1.L
uniprot id: A0A1L8HJE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

8355:slc20a1.S
gene id: 8355:slc20a1.S
uniprot id: Q68F35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

8355:senp3.S
gene id: 8355:senp3.S
uniprot id: A0A8J0U3G6
uniprot id: A0A8J0U5F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

8355:LOC108711683
gene id: 8355:LOC108711683
uniprot id: A0A8J0ULC2
uniprot id: A0A8J1MMY4
uniprot id: A0A8J1MN19
uniprot id: A0A8J1MNX9
uniprot id: A0A8J1MQ13
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108709142
gene id: 8355:LOC108709142
uniprot id: A0A1L8HAR3
names: Similarity
messages: Belongs to the peptidase M10A family.

8355:LOC108697876
gene id: 8355:LOC108697876
uniprot id: A0A1L8FHN0
uniprot id: A0A8J1LE22
names: Similarity
messages: Belongs to the CAMK2N family.

8355:sh3glb1.S
gene id: 8355:sh3glb1.S
uniprot id: A0A8J1N0I5
uniprot id: Q6GQK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Mitochondrion outer membrane

8355:axin1.L
gene id: 8355:axin1.L
uniprot id: A0A1L8EYQ2
uniprot id: Q9YGY0
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylated by tankyrase tnks and tnks2. Poly-ADP-ribosylated protein is recognized by rnf146, followed by ubiquitination at 'Lys-48' and subsequent activation of the Wnt signaling pathway.
messages: Cell membrane
messages: Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.
messages: Cytoplasm
messages: Homodimer (By similarity). Interacts with hwa; leading to promote the tankyrase-mediated degradation of axin1 (By similarity).
messages: Membrane
messages: Nucleus
messages: Ubiquitinated by rnf146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway.
messages: Weakly and ubiquitously expressed throughout early development, and highly expressed in the anterior mesencephalon adjacent to the forebrain-midbrain boundary.

8355:cpsf2.S
gene id: 8355:cpsf2.S
uniprot id: A0A8J1LLC5
uniprot id: Q9W799
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: CPSF is a heterotetramer composed of four distinct subunits 160, 100, 70 and 30 kDa (By similarity). Identification in a complex with cpsf2, cpsf73, cpsf160 and sympk. Interacts with sympk.
messages: CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. In X.laevis this subunit seems to be predominantly involved in cytoplasmic polyadenylation reaction. May also be involved in the histone 3'-end pre-mRNA processing.
messages: Cytoplasm
messages: Nucleus

8355:gsdme.L
gene id: 8355:gsdme.L
uniprot id: Q6DCC3
names: Similarity
messages: Belongs to the gasdermin family.

8355:nkain3.S
gene id: 8355:nkain3.S
uniprot id: A0A8J1L3G4
uniprot id: Q66KZ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Interacts with atp1b1 C-terminus.
messages: Membrane

8355:trpm4.L
gene id: 8355:trpm4.L
uniprot id: A0A1L8FNQ3
uniprot id: A0A8J1L7S4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108708803
gene id: 8355:LOC108708803
uniprot id: A0A8J1MAS0
uniprot id: A0A8J1MAS1
uniprot id: A0A8J1MBS0
uniprot id: A0A8J1MCJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC121400568
gene id: 8355:LOC121400568
uniprot id: A0A8J1MFK7
names: Similarity
messages: Belongs to the RNase Z family.

8355:fads1.L
gene id: 8355:fads1.L
uniprot id: A0A1L8GJ66
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

8355:XB5764007.L
gene id: 8355:XB5764007.L
uniprot id: A0JPH2
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

8355:pdlim1.S
gene id: 8355:pdlim1.S
uniprot id: A0A8J1LA13
uniprot id: A0A8J1LA47
uniprot id: A0A8J1LCJ0
uniprot id: Q7ZYS4
names: Subcellular Location Annotation
messages: Z line

8355:ccdc149.S
gene id: 8355:ccdc149.S
uniprot id: A0A1L8HKX7
uniprot id: A0A8J0TXV6
names: Similarity
messages: Belongs to the CCDC149 family.

8355:mpped2.S
gene id: 8355:mpped2.S
uniprot id: Q6GLV7
names: Similarity
messages: Belongs to the UPF0046 family.

8355:LOC121393962
gene id: 8355:LOC121393962
uniprot id: A0A8J1KSL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121399472
gene id: 8355:LOC121399472
uniprot id: A0A8J1M540
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:gldc.S
gene id: 8355:gldc.S
uniprot id: Q8AVC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

8355:LOC121402259
gene id: 8355:LOC121402259
uniprot id: A0A8J1MSM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:f13a1.L
gene id: 8355:f13a1.L
uniprot id: A0A8J1KY23
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8355:LOC108696474
gene id: 8355:LOC108696474
uniprot id: A0A8J0T2A2
uniprot id: A0A8J0TAU8
uniprot id: A0A8J1L9C3
names: Similarity
messages: Belongs to the FAM154 family.

8355:spata18a.L
gene id: 8355:spata18a.L
uniprot id: A0A1L8H1R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

8355:LOC108712980
gene id: 8355:LOC108712980
uniprot id: A0A8J1MSF6
uniprot id: A0A8J1MTF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

8355:LOC108705888
gene id: 8355:LOC108705888
uniprot id: A0A8J1LY16
names: Similarity
messages: Belongs to the cyclin family.

8355:mcmbp.L
gene id: 8355:mcmbp.L
uniprot id: A0A8J0SZ10
uniprot id: A0A8J0T5V8
uniprot id: A0A8J0T905
uniprot id: Q7ZYP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the mcm complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. May also be required for sister chromatid cohesion.
messages: Belongs to the MCMBP family.
messages: Interacts with the mcm complex: associates with the mcm3-7 complex which lacks mcm2, while it does not interact with the mcm complex when mcm2 is present (mcm2-7 complex). Interacts with mcm7.
messages: Nucleus

8355:arl6ip5.L
gene id: 8355:arl6ip5.L
uniprot id: A0A8J0UYX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

8355:oat.S
gene id: 8355:oat.S
uniprot id: Q6DE30
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

8355:lbr.S
gene id: 8355:lbr.S
uniprot id: Q9W708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

8355:LOC108719358
gene id: 8355:LOC108719358
uniprot id: A0A1L8FZP6
names: Similarity
messages: Belongs to the TGF-beta family.

8355:dnajc16.S
gene id: 8355:dnajc16.S
uniprot id: A0A1L8FHP4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108708335
gene id: 8355:LOC108708335
uniprot id: A0A1L8HG58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

8355:actb.L
gene id: 8355:actb.L
uniprot id: O93400
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylation at His-73 by SETD3. Methylation stabilizes actin filaments.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (By similarity). Each actin can bind to 4 others (By similarity).
messages: cytoskeleton

8355:rnps1.L
gene id: 8355:rnps1.L
uniprot id: A0A8J0TSK9
uniprot id: Q3KPW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the splicing factor SR family.
messages: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Putative component of the spliceosome which enhances the formation of the ATP-dependent A complex of the spliceosome. May participate in mRNA 3'-end cleavage. Also mediates increase of mRNA abundance and translational efficiency (By similarity).
messages: Component of the active spliceosome.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle

8355:ncaph.S
gene id: 8355:ncaph.S
uniprot id: A0A8J0UUC0
uniprot id: O13067
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Component of the condensin complex, which contains the XCAP-E/SMC2 and XCAP-C/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: XCAP-H/NCAPH, XCAP-D2/NCAPD2 and XCAP-G/NCAPG.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated by CDK1. Its phosphorylation, as well as that of XCAP-D2 and XCAP-G subunits, activates the condensin complex and is required for chromosome condensation.
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerase.

8355:LOC121397876
gene id: 8355:LOC121397876
uniprot id: A0A8J1LSW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

8355:LOC108717497
gene id: 8355:LOC108717497
uniprot id: A0A8J1KUL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

8355:atp6v1b1.L
gene id: 8355:atp6v1b1.L
uniprot id: Q05AW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

8355:klhl21.L
gene id: 8355:klhl21.L
uniprot id: Q5U575
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of cul3, klhl21 and rbx1.
messages: Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity).
messages: spindle

8355:ube2k.L
gene id: 8355:ube2k.L
uniprot id: A0A8J0THX4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:cab39.S
gene id: 8355:cab39.S
uniprot id: A0A1L8G4K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

8355:tbca.S
gene id: 8355:tbca.S
uniprot id: Q6DKM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

8355:cetn1.S
gene id: 8355:cetn1.S
uniprot id: Q7SYA4
names: Similarity
messages: Belongs to the centrin family.

8355:LOC121395402
gene id: 8355:LOC121395402
uniprot id: A0A8J1L8B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

8355:slc4a4.L
gene id: 8355:slc4a4.L
uniprot id: A0A1L8HVC4
uniprot id: A0A8J0UIT8
uniprot id: A0A8J1MYP9
uniprot id: A0A8J1N0I4
uniprot id: A0A8J1N199
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

8355:hbs1l.L
gene id: 8355:hbs1l.L
uniprot id: A0A8J1KLE2
uniprot id: A0A8J1KN18
uniprot id: Q6GNS6
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Interacts with the SKI complex.

8355:gpr158.L
gene id: 8355:gpr158.L
uniprot id: A0A1L8FVG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8355:LOC108697312
gene id: 8355:LOC108697312
uniprot id: A0A8J0TBF8
uniprot id: A0A8J1LCQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane

8355:tmem251-b
gene id: 8355:tmem251-b
uniprot id: A0A1L8F0B0
uniprot id: Q6GLZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Belongs to the TMEM251 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases.

8355:LOC121400413
gene id: 8355:LOC121400413
uniprot id: A0A8J1ME79
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:bbox1.S
gene id: 8355:bbox1.S
uniprot id: A0A1L8GDF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
messages: Cytoplasm

8355:XB5817455.S
gene id: 8355:XB5817455.S
uniprot id: A0A1L8FEG9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:LOC108708365
gene id: 8355:LOC108708365
uniprot id: A0A8J0UI92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

8355:LOC108709358
gene id: 8355:LOC108709358
uniprot id: A0A8J1ME27
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:mpc1.S
gene id: 8355:mpc1.S
uniprot id: A0A8J0VAN8
uniprot id: Q5M994
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

8355:LOC108706077
gene id: 8355:LOC108706077
uniprot id: A0A8J1LY63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

8355:mfsd14bl.L
gene id: 8355:mfsd14bl.L
uniprot id: A0A1L8HYK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8355:cactin.L
gene id: 8355:cactin.L
uniprot id: A0A1L8HW42
names: Similarity
messages: Belongs to the CACTIN family.

8355:LOC108719346
gene id: 8355:LOC108719346
uniprot id: A0A1L8HSD5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC121401314
gene id: 8355:LOC121401314
uniprot id: A0A8J1MJF7
names: Subcellular Location Annotation
messages: Membrane

8355:palm2akap2.L
gene id: 8355:palm2akap2.L
uniprot id: A0A1L8HXB4
uniprot id: A0A8J0QHU6
uniprot id: A0A8J1MHH3
uniprot id: A0A8J1MI94
uniprot id: A0A8J1MIK0
uniprot id: A0A8J1MJC8
names: Similarity
messages: Belongs to the paralemmin family.

8355:tox4.L
gene id: 8355:tox4.L
uniprot id: A0A8J0UAW9
uniprot id: A0A8J0UB29
uniprot id: Q6IRR0
names: Subcellular Location Annotation
messages: Nucleus

8355:plod2.L
gene id: 8355:plod2.L
uniprot id: A0A1L8GAM0
uniprot id: A0A8J0VDB4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8355:LOC121394627
gene id: 8355:LOC121394627
uniprot id: A0A8J1KXG5
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:il1rap.S
gene id: 8355:il1rap.S
uniprot id: A0A1L8G3Y5
uniprot id: A0A8J0VGY6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8355:ncf2.L
gene id: 8355:ncf2.L
uniprot id: Q6GMC8
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

8355:fxr1.S
gene id: 8355:fxr1.S
uniprot id: A0A1L8G447
uniprot id: Q7ZTQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein. Binds poly(G) and poly(U) but not poly(A) or poly(C). Regulates somite formation, probably by regulating gene expression (By similarity).

8355:nsun7.L
gene id: 8355:nsun7.L
uniprot id: B1H1T1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121394549
gene id: 8355:LOC121394549
uniprot id: A0A8J1L061
names: Subcellular Location Annotation
messages: Membrane

8355:celsr1.L
gene id: 8355:celsr1.L
uniprot id: A0A8J1MKT6
uniprot id: A0A8J1MKV7
uniprot id: A0A8J1MLN6
uniprot id: A0A8J1MLS9
uniprot id: A0A8J1MMV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

8355:ltn1.L
gene id: 8355:ltn1.L
uniprot id: A0A1L8HCQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

8355:pon2.S
gene id: 8355:pon2.S
uniprot id: Q6IRR7
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

8355:alms1.S
gene id: 8355:alms1.S
uniprot id: A0A8J1M0J2
uniprot id: A0A8J1M0L2
uniprot id: A0A8J1M0N8
uniprot id: A0A8J1M1R2
uniprot id: A0A8J1M2K2
names: Subcellular Location Annotation
messages: centrosome

8355:etv6.L
gene id: 8355:etv6.L
uniprot id: A0A8J0TWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:coq10a.L
gene id: 8355:coq10a.L
uniprot id: A0A8J1M5I2
uniprot id: Q6DFA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Mitochondrion inner membrane
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

8355:myb100496870.2provisional.L
gene id: 8355:myb100496870.2provisional.L
uniprot id: A0A8J1L6P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8355:phactr4.L
gene id: 8355:phactr4.L
uniprot id: A0A1L8HE88
uniprot id: A0A1L8HEA9
uniprot id: A0A8J0UB60
uniprot id: A0A8J0UCF7
uniprot id: Q5XHF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Binds ppp1ca and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity).
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

8355:LOC108704405
gene id: 8355:LOC108704405
uniprot id: A0A8J0U578
uniprot id: A0A8J0U7A9
uniprot id: A0A8J1KM60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

8355:hormad1.S
gene id: 8355:hormad1.S
uniprot id: Q5M7C8
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus
messages: Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal-complex formation independently and playing key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint.

8355:sim2.S
gene id: 8355:sim2.S
uniprot id: A0A8J1MB09
uniprot id: Q9DDU6
names: Subcellular Location Annotation
messages: Nucleus

8355:dph6.L
gene id: 8355:dph6.L
uniprot id: A0A8J0TEP5
uniprot id: A0A8J1LEW0
uniprot id: Q6GPL5
names: Similarity
messages: Belongs to the Diphthine--ammonia ligase family.

8355:LOC121397335
gene id: 8355:LOC121397335
uniprot id: A0A8J1LJZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:mmp2.S
gene id: 8355:mmp2.S
uniprot id: Q8UUZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

8355:zbed4.L
gene id: 8355:zbed4.L
uniprot id: A0A1L8GZ16
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108708431
gene id: 8355:LOC108708431
uniprot id: A0A1L8HGW9
uniprot id: A0A8J1M9M9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:adra2c.L
gene id: 8355:adra2c.L
uniprot id: A0A1L8HT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:bmp3.S
gene id: 8355:bmp3.S
uniprot id: A0A1L8HMZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

8355:ldb2.S
gene id: 8355:ldb2.S
uniprot id: A0A8J1MB03
uniprot id: Q1EQW7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the LDB family.
messages: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.
messages: Expressed in adult brain, lung, spleen and kidney. Isoform b is generally expressed at a higher level than isoform a.
messages: Expressed weakly in the stage 10/10.5 embryo. Expression then resumes after stage 25.
messages: Nucleus

8355:fbxo31.L
gene id: 8355:fbxo31.L
uniprot id: A0A8J0USA6
uniprot id: A2BD94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBXO31 family.
messages: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

8355:plxna1.L
gene id: 8355:plxna1.L
uniprot id: A0A1L8GPU4
uniprot id: Q91823
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:dnah1.L
gene id: 8355:dnah1.L
uniprot id: A0A1L8GPB6
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:sfxn2.L
gene id: 8355:sfxn2.L
uniprot id: A0A8J1L4Z1
uniprot id: A0A8J1L515
uniprot id: A0A8J1L6Q3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

8355:rock2.S
gene id: 8355:rock2.S
uniprot id: A0A1L8G5H9
uniprot id: A0A8J0VDB1
uniprot id: B7ZRE4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
messages: centrosome

8355:LOC108697860
gene id: 8355:LOC108697860
uniprot id: A0A8J1LDU0
names: Similarity
messages: Belongs to the FAM131 family.

8355:cenpn.L
gene id: 8355:cenpn.L
uniprot id: Q5U4T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-N/CHL4 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere

8355:lpar5.S
gene id: 8355:lpar5.S
uniprot id: A0A1L8FDZ3
uniprot id: A0A8J0T5I5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108719003
gene id: 8355:LOC108719003
uniprot id: A0A1L8FWU8
uniprot id: A0A8J0VGR2
uniprot id: A0A8J0VJD9
uniprot id: A0A8J1KXM9
uniprot id: A0A8J1KXN2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:fam189b.L
gene id: 8355:fam189b.L
uniprot id: A0A8J0TMN9
uniprot id: A0A8J1LJU7
uniprot id: A0A8J1LKJ2
names: Similarity
messages: Belongs to the ENTREP family.

8355:KEF37 p13
gene id: 8355:KEF37_p13
uniprot id: P03890
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

8355:prune2.L
gene id: 8355:prune2.L
uniprot id: A0A8J1MHL6
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

8355:anxa3.L
gene id: 8355:anxa3.L
uniprot id: Q6GQ58
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

8355:LOC108701967
gene id: 8355:LOC108701967
uniprot id: A0A1L8EZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:notch1.S
gene id: 8355:notch1.S
uniprot id: P21783
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Expressed almost uniformly in early embryos.
messages: Forms a ternary complex with nrarp and rbpj/suh.
messages: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).
messages: Nucleus
messages: O-glycosylated on the EGF-like domains. Contains both O-linked fucose and O-linked glucose. O-linked glycosylation by galnt11 is involved in determination of left/right symmetry: glycosylation promotes activation of notch1, possibly by promoting cleavage by adam17, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity).
messages: Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by adam17 to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). Following endocytosis, this fragment is then cleaved by presenilin dependent gamma-secretase to release a Notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).

8355:col11a1.L
gene id: 8355:col11a1.L
uniprot id: A0A8J1MXA8
uniprot id: A0A8J1MXJ6
uniprot id: A0A8J1MYG0
uniprot id: A0A8J1MZ02
uniprot id: A0A8J1MZS7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tmprss9.S
gene id: 8355:tmprss9.S
uniprot id: A0A1L8HMU1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:ephb4.L
gene id: 8355:ephb4.L
uniprot id: Q32NP2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108696036
gene id: 8355:LOC108696036
uniprot id: A0A8J1L9B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8355:fam98b.L
gene id: 8355:fam98b.L
uniprot id: Q6DDR4
names: Similarity
messages: Belongs to the FAM98 family.

8355:lgalsl.L
gene id: 8355:lgalsl.L
uniprot id: A0A8J0V949
uniprot id: Q6DDR8
names: Caution
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.
messages: Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved.

8355:LOC108699081
gene id: 8355:LOC108699081
uniprot id: A0A1L8FBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:nucb2.S
gene id: 8355:nucb2.S
uniprot id: Q6NTN7
names: Similarity
messages: Belongs to the nucleobindin family.

8355:tmbim6.S
gene id: 8355:tmbim6.S
uniprot id: Q7ZWL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8355:LOC108706606
gene id: 8355:LOC108706606
uniprot id: A0A8J1M137
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8355:LOC108718636
gene id: 8355:LOC108718636
uniprot id: A0A8J1KYU8
names: Subcellular Location Annotation
messages: Membrane

8355:gipr.S
gene id: 8355:gipr.S
uniprot id: A0A8J1LPM6
names: Subcellular Location Annotation
messages: Membrane

8355:dnajc16.L
gene id: 8355:dnajc16.L
uniprot id: A0A1L8FPF2
names: Subcellular Location Annotation
messages: Membrane

8355:mff.S
gene id: 8355:mff.S
uniprot id: A0A1L8G4S2
uniprot id: A0A8J0VAJ1
uniprot id: A0A8J0VDT0
uniprot id: A0A8J1KVZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

8355:LOC108708225
gene id: 8355:LOC108708225
uniprot id: A0A1L8HFE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

8355:ap3b1.L
gene id: 8355:ap3b1.L
uniprot id: A0A8J0UBM7
uniprot id: Q52KY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

8355:cdk9.S
gene id: 8355:cdk9.S
uniprot id: A0A8J1LM15
uniprot id: A0A8J1LNJ9
uniprot id: Q4V862
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with cyclin-T to form P-TEFb.
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H.
messages: Nucleus

8355:actn3.L
gene id: 8355:actn3.L
uniprot id: Q6DFU3
names: Similarity
messages: Belongs to the alpha-actinin family.

8355:LOC108704467
gene id: 8355:LOC108704467
uniprot id: A0A8J1LHN1
uniprot id: A0A8J1LHR3
uniprot id: A0A8J1LIA6
uniprot id: A0A8J1LJ18
uniprot id: A0A8J1LK51
names: Similarity
messages: Belongs to the filamin family.

8355:optn.L
gene id: 8355:optn.L
uniprot id: A0A8J0UG42
uniprot id: A0A8J0UNX9
uniprot id: Q5M7B7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Endosome
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

8355:scara5.S
gene id: 8355:scara5.S
uniprot id: A0A1L8G670
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCARA5 family.
messages: Cell membrane
messages: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.
messages: Homotrimer.
messages: Membrane

8355:ypel1.L
gene id: 8355:ypel1.L
uniprot id: Q6DDQ0
names: Similarity
messages: Belongs to the yippee family.

8355:ddx6.L
gene id: 8355:ddx6.L
uniprot id: P54824
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-dependent RNA helicase that is an integral component of messenger ribonucleoprotein complexes (mRNPs), storage particles that mask maternal mRNAs from the translational apparatus during oocyte maturation.
messages: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
messages: Component of a ribonucleoprotein (RNP) complex, composed at least of cpeb1, lsm14b/rap55b, ddx6/Xp54, ybx2/frgy2, pat1/P100, eif4enif1/4E-T and eif4e1b. Component of a ribonucleoprotein (RNP) complex, composed at least of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen. Component of a ribonucleoprotein (RNP) complex, composed at least of lsm14a/rap55a, ybx2/frgy2, ddx6/Xp54 and eif4enif1/4E-T. Interacts with lsm14a/rap55a.
messages: Cytoplasm
messages: Expressed maternally. Expression peaks at stage I of oogenesis and remains fairly constant through to the end of oogenesis and, after fertilization, up to blastula. From blastula, through gastrula and neurula, expression declines significantly. May also be expressed zygotically since a low level of expression is detected up to the free-feeding tadpole stage (embryonic stage 42) (at protein level).
messages: In adults, expression is restricted to the germline cells of the ovary.
messages: Nucleus
messages: P-body

8355:LOC121393514
gene id: 8355:LOC121393514
uniprot id: A0A8J1KNI0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121396152
gene id: 8355:LOC121396152
uniprot id: A0A8J1LAU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:ephx1.L
gene id: 8355:ephx1.L
uniprot id: A0A1L8G6J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

8355:slc15a4.L
gene id: 8355:slc15a4.L
uniprot id: Q68F72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Lysosome membrane
messages: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (By similarity). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity).

8355:limd1.L
gene id: 8355:limd1.L
uniprot id: A0A1L8FX11
uniprot id: Q06BR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development.
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Interacts with snai1.
messages: Nucleus

8355:slc30a4.S
gene id: 8355:slc30a4.S
uniprot id: A0A1L8GSV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8355:LOC108700218
gene id: 8355:LOC108700218
uniprot id: Q6NTT2
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

8355:mthfr.S
gene id: 8355:mthfr.S
uniprot id: A0A1L8FFK7
uniprot id: A0A8J0TCD3
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

8355:cfap298.S
gene id: 8355:cfap298.S
uniprot id: A0A8J1ME41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

8355:hscb.L
gene id: 8355:hscb.L
uniprot id: A0A1L8I061
uniprot id: A0A8J0UBL0
uniprot id: Q6GM83
names: Similarity
messages: Belongs to the HscB family.

8355:LOC108708435
gene id: 8355:LOC108708435
uniprot id: A0A1L8HH36
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108703424
gene id: 8355:LOC108703424
uniprot id: A0A8J0U314
names: Subcellular Location Annotation
messages: Membrane

8355:slc16a3.S
gene id: 8355:slc16a3.S
uniprot id: A0A8J0U4N0
uniprot id: Q7ZXP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

8355:parp14
gene id: 8355:parp14
uniprot id: A0A1L8EV73
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:LOC108715138
gene id: 8355:LOC108715138
uniprot id: A0A1L8GD86
uniprot id: A0A8J0V4F8
uniprot id: A0A8J0V576
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

8355:cx38.S
gene id: 8355:cx38.S
uniprot id: Q6NUE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:vgll4l.S
gene id: 8355:vgll4l.S
uniprot id: A0A1L8F0R4
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

8355:alx1.S
gene id: 8355:alx1.S
uniprot id: A0A1L8GUS3
uniprot id: A0A8J1MSZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8355:LOC108706614
gene id: 8355:LOC108706614
uniprot id: A0A8J0U765
names: Similarity
messages: Belongs to the FAM149 family.

8355:LOC108695640
gene id: 8355:LOC108695640
uniprot id: A0A1L8HZL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:rasgrp3.S
gene id: 8355:rasgrp3.S
uniprot id: A0A1L8G260
uniprot id: A0A8J1KUC8
names: Similarity
messages: Belongs to the RASGRP family.

8355:tlx3.S
gene id: 8355:tlx3.S
uniprot id: Q9DFC2
names: Subcellular Location Annotation
messages: Nucleus

8355:kcnj12.L
gene id: 8355:kcnj12.L
uniprot id: A0A1L8EX89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Cell membrane
messages: Membrane

8355:chmp1b.S
gene id: 8355:chmp1b.S
uniprot id: Q7SZB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Endosome
messages: Late endosome membrane
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.
messages: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III).
messages: cytosol

8355:tmod3.L
gene id: 8355:tmod3.L
uniprot id: A0A8J0UER1
uniprot id: A1DPK8
names: Subcellular Location Annotation
messages: cytoskeleton

8355:otud7b.S
gene id: 8355:otud7b.S
uniprot id: A0A1L8F4J1
uniprot id: A0A8J0TPG1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:chrm4.L
gene id: 8355:chrm4.L
uniprot id: A0A1L8GIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

8355:rpl37.L
gene id: 8355:rpl37.L
uniprot id: A0A1L8I2F1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

8355:LOC121394656
gene id: 8355:LOC121394656
uniprot id: A0A8J1KXU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8355:elp6.L
gene id: 8355:elp6.L
uniprot id: Q0IHA2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ELP6 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
messages: Component of the elongator complex.
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

8355:txlnb.L
gene id: 8355:txlnb.L
uniprot id: A0A8J1KN71
uniprot id: A0A8J1KN77
uniprot id: A0A8J1KPV1
names: Similarity
messages: Belongs to the taxilin family.

8355:ptprf.S
gene id: 8355:ptprf.S
uniprot id: A0A1L8GFK2
uniprot id: A0A8J0V2F9
uniprot id: A0A8J1KJ44
uniprot id: A0A8J1KJ51
uniprot id: A0A8J1KJ55
uniprot id: A0A8J1KJ60
uniprot id: A0A8J1KJ65
uniprot id: A0A8J1KJ67
uniprot id: A0A8J1KJ70
uniprot id: A0A8J1KJ77
uniprot id: A0A8J1KKU6
uniprot id: A0A8J1KKV2
uniprot id: A0A8J1KKV7
uniprot id: A0A8J1KKW2
uniprot id: A0A8J1KMA5
uniprot id: A0A8J1KMB5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

8355:bckdha.S
gene id: 8355:bckdha.S
uniprot id: A0A8J0TR14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

8355:cdc14a.S
gene id: 8355:cdc14a.S
uniprot id: A0A1L8GGF5
uniprot id: A0A8J0VC07
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

8355:slc13a2.L
gene id: 8355:slc13a2.L
uniprot id: A0A8J0UE12
uniprot id: A0A8J0UGL0
uniprot id: A0A8J1M7I4
uniprot id: A0A8J1M7I7
uniprot id: A0A8J1M8K5
uniprot id: A0A8J1M9C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8355:LOC108697466
gene id: 8355:LOC108697466
uniprot id: A0A8J0TE07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:shmt2.S
gene id: 8355:shmt2.S
uniprot id: A0A1L8H9S2
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

8355:barx2.S
gene id: 8355:barx2.S
uniprot id: A0A1L8FFP7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121394495
gene id: 8355:LOC121394495
uniprot id: A0A8J1KWB5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:tmem111.S
gene id: 8355:tmem111.S
uniprot id: Q7ZY15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

8355:wnt2b.L
gene id: 8355:wnt2b.L
uniprot id: P87387
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Expressed both maternally and zygotically. Expression accumulates from stage 17 (neurula stage) onwards.
messages: Expressed maternally in both vegetal and animal blastomeres with enrichment in the animal hemisphere. Expressed zygotically near the prosencephalic-mesencephalic boundary of the developing brain in neurula and tailbud stages, and also in non-brain areas at tadpole stages.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway.
messages: Originally called wnt-2b by PubMed:9203142. Although PubMed:12084573 renames it as wnt-2, it is considered to be a wnt2b paralog by Xenbase.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

8355:LOC121400435
gene id: 8355:LOC121400435
uniprot id: A0A8J1MDN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:mmp17.L
gene id: 8355:mmp17.L
uniprot id: A0A1L8I0U7
uniprot id: A0A8J1L0R4
names: Similarity
messages: Belongs to the peptidase M10A family.

8355:LOC108716239
gene id: 8355:LOC108716239
uniprot id: A0A8J1KQ53
uniprot id: A0A8J1KT92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:LOC108717528
gene id: 8355:LOC108717528
uniprot id: A0A1L8G0P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:LOC733375
gene id: 8355:LOC733375
uniprot id: A0A1L8ELD5
uniprot id: A0A8J1LWS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

8355:mtcl1.L
gene id: 8355:mtcl1.L
uniprot id: A0A1L8FYI7
uniprot id: A0A8J0VHD9
uniprot id: A0A8J0VK02
uniprot id: A0A8J0VL17
names: Similarity
messages: Belongs to the SOGA family.

8355:cldn2.L
gene id: 8355:cldn2.L
uniprot id: A0A1L8F6M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:LOC108701136
gene id: 8355:LOC108701136
uniprot id: A0A1L8EUI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:LOC108702199
gene id: 8355:LOC108702199
uniprot id: A0A8J0TY68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:LOC121394307
gene id: 8355:LOC121394307
uniprot id: A0A8J1KVQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:LOC108711012
gene id: 8355:LOC108711012
uniprot id: A0A1L8GY14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8355:pemt.L
gene id: 8355:pemt.L
uniprot id: A0A1L8EYQ8
uniprot id: Q66KT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

8355:elavl1.S
gene id: 8355:elavl1.S
uniprot id: A0A1L8HNJ9
uniprot id: Q5U259
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Interacts (via RRM3) with cirbp. Unable to form oligomers (By similarity). Part of a ribonucleoprotein (RNP) complex, at least composed of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen.
messages: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Acts cooperatively with cribp to stabilize AU-rich sequence (ARE)-containing mRNAs. May play a role during gastrulation. Required for the vegetal localization of vg1 mRNA.
messages: cell cortex

8355:antkmt.L
gene id: 8355:antkmt.L
uniprot id: Q6DK97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

8355:itpa.S
gene id: 8355:itpa.S
uniprot id: A0A8J0V4V6
uniprot id: Q2NLA8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

8355:mtmr9.L
gene id: 8355:mtmr9.L
uniprot id: Q5PQ14
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8355:LOC108715162
gene id: 8355:LOC108715162
uniprot id: A0A1L8GD12
names: Similarity
messages: Belongs to the ATG8 family.

8355:fbn3.S
gene id: 8355:fbn3.S
uniprot id: A0A8J1M260
uniprot id: A0A8J1M397
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:dkk3.S
gene id: 8355:dkk3.S
uniprot id: A0A8J1MYU2
uniprot id: Q08AZ9
names: Similarity
messages: Belongs to the dickkopf family.

8355:MGC115163.L
gene id: 8355:MGC115163.L
uniprot id: Q566F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

8355:LOC108699757
gene id: 8355:LOC108699757
uniprot id: A0A1L8EZY7
names: Subcellular Location Annotation
messages: Membrane

8355:pcnx1.S
gene id: 8355:pcnx1.S
uniprot id: A0A1L8EZX8
uniprot id: A0A8J0TFB4
uniprot id: A0A8J0TNY0
uniprot id: A0A8J0TQ05
uniprot id: A0A8J1LMN4
uniprot id: A0A8J1LMT8
uniprot id: A0A8J1LNR2
uniprot id: A0A8J1LNR7
uniprot id: A0A8J1LNU5
uniprot id: A0A8J1LQ45
uniprot id: A0A8J1LQ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

8355:zeb2.L
gene id: 8355:zeb2.L
uniprot id: A0A8J1LVE9
uniprot id: A0A8J1LVF7
uniprot id: A0A8J1LVG3
uniprot id: A0A8J1LVW1
uniprot id: A0A8J1LWS4
uniprot id: A0A8J1LXM8
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

8355:adra2c.S
gene id: 8355:adra2c.S
uniprot id: A0A8J0U6H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:dcps.L
gene id: 8355:dcps.L
uniprot id: Q4KLD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

8355:LOC121395096
gene id: 8355:LOC121395096
uniprot id: A0A8J1L3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.
messages: Nucleus

8355:tmem35b.S
gene id: 8355:tmem35b.S
uniprot id: A0A1L8H7L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

8355:mpzl3.L
gene id: 8355:mpzl3.L
uniprot id: Q8AVM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin P0 protein family.
messages: Mediates homophilic cell-cell adhesion.
messages: Membrane

8355:gnpat.S
gene id: 8355:gnpat.S
uniprot id: A0A8J0VC43
uniprot id: A0A8J0VEX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

8355:LOC108710396
gene id: 8355:LOC108710396
uniprot id: A0A8J0USA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:wdr82.L
gene id: 8355:wdr82.L
uniprot id: Q640J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SWD2 family.
messages: Chromosome
messages: Component of the SET1 complex.
messages: Nucleus
messages: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

8355:gem.L
gene id: 8355:gem.L
uniprot id: A0A1L8FZH7
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

8355:il1rap.L
gene id: 8355:il1rap.L
uniprot id: A0A1L8GAA2
uniprot id: A0A8J1KPF4
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8355:LOC108696273
gene id: 8355:LOC108696273
uniprot id: A0A1L8HSK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:otud6b.L
gene id: 8355:otud6b.L
uniprot id: Q6GM06
names: Function
messages: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes.

8355:LOC108716097
gene id: 8355:LOC108716097
uniprot id: A0A1L8I0P3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108709141
gene id: 8355:LOC108709141
uniprot id: A0A1L8HAW2
names: Similarity
messages: Belongs to the peptidase M10A family.

8355:slc66a1l.L
gene id: 8355:slc66a1l.L
uniprot id: A0A1L8GAF2
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108709337
gene id: 8355:LOC108709337
uniprot id: A0A1L8H678
uniprot id: A0A8J0UBQ9
uniprot id: A0A8J1MDE4
uniprot id: A0A8J1MET7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

8355:twsg1.L
gene id: 8355:twsg1.L
uniprot id: Q9I8M9
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the twisted gastrulation protein family.
messages: Binds directly to bmp2, bmp4 and bmp7 and can form a ternary complex with bmps and chordin, thus preventing the binding of bmps to their cell surface receptors.
messages: Involved in dorsal-ventral patterning, permitting peak BMP signaling by antagonizing the residual anti-BMP activity of the cleavage products of chrd. Functions to promote the formation of ventral mesoderm by increasing the activity of bmp7 and other BMPS. Seems to antagonize BMP signaling by forming ternary complexes with chrd and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of chrd, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation.
messages: Knockdown of tsg and bmp7 results in the siren phenotype with loss of posteroventral cell fates associated with decreased BMP activity.
messages: Maternal transcripts are distributed throughout animal half of the embryo during cleavage stages. At the late gastrula stage, maternal transcripts decrease and zygotic transcripts appear specifically in the ventral region of the embryo. After neurulation, expressed ventrally in the closed blastopore slit and the neural tube. At the tailbud stage, detected in the postanal region, heart and dorsal eye.
messages: Secreted
messages: The N-terminal domain is sufficient to interact with bmp4.

8355:slc13a1.S
gene id: 8355:slc13a1.S
uniprot id: A0A8J1MSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8355:nrn1l.S
gene id: 8355:nrn1l.S
uniprot id: A0A1L8GE86
names: Similarity
messages: Belongs to the neuritin family.

8355:prps2.L
gene id: 8355:prps2.L
uniprot id: Q7ZXC9
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3-bisphosphoglyceride or GDP (By similarity).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).

8355:pdgfrl.L
gene id: 8355:pdgfrl.L
uniprot id: Q6INL1
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Secreted

8355:astl3a.1.L
gene id: 8355:astl3a.1.L
uniprot id: A0A8J1LEL8
uniprot id: B7ZQ15
uniprot id: P42664
names: Caution
names: Cofactor
names: Developmental Stage
messages: Binds 1 zinc ion per subunit.
messages: Exclusively in the anterior neural fold of neurula stage embryos. By the tailbud stage, the protein is localized in specialized cephalic ectoderm, in a region probably corresponding to the hatching gland.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:pam16.S
gene id: 8355:pam16.S
uniprot id: A0A8J0TQU5
uniprot id: Q5M995
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM16/PAM16 family.
messages: Mitochondrion inner membrane
messages: Probable component of the PAM complex at least composed of 1 mitochondrial HSP70 protein, 1 GRPE, 1 TIMM44, 1 TIMM16/PAM16 and 1 TIMM14.
messages: Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May be required to regulate the ATP-dependent activity (By similarity).
messages: The J-like region, although related to the J domain does not have co-chaperone activity.

8355:srf.L
gene id: 8355:srf.L
uniprot id: A0A8J0V7X3
uniprot id: B7ZPQ5
uniprot id: P23790
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a multimer, probably a dimer.
messages: Nucleus
messages: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration.

8355:exoc4.L
gene id: 8355:exoc4.L
uniprot id: A0A1L8GZQ8
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

8355:clca1.2.L
gene id: 8355:clca1.2.L
uniprot id: F7IYU5
names: Similarity
messages: Belongs to the CLCR family.

8355:LOC108705948
gene id: 8355:LOC108705948
uniprot id: A0A8J1LZ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:ifrd2.L
gene id: 8355:ifrd2.L
uniprot id: A0A8J0UZK6
uniprot id: A0A8J1MVQ0
uniprot id: Q6AZE7
names: Similarity
messages: Belongs to the IFRD family.

8355:mesd.S
gene id: 8355:mesd.S
uniprot id: A0A1L8GSS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

8355:LOC121395389
gene id: 8355:LOC121395389
uniprot id: A0A8J1L6Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

8355:cnot8.L
gene id: 8355:cnot8.L
uniprot id: A0A1L8GWV2
uniprot id: A0A8J1MKJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

8355:LOC121400696
gene id: 8355:LOC121400696
uniprot id: A0A1L8HX30
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:kcna10.S
gene id: 8355:kcna10.S
uniprot id: A0A1L8H686
names: Subcellular Location Annotation
messages: Membrane

8355:stxbp5.L
gene id: 8355:stxbp5.L
uniprot id: A0A1L8G871
uniprot id: A0A8J0V7E7
uniprot id: A0A8J0V7F2
uniprot id: A0A8J0VAG0
uniprot id: A0A8J0VAG5
uniprot id: A0A8J0VB15
uniprot id: A0A8J0VB19
uniprot id: A0A8J0VBS3
uniprot id: A0A8J0VFZ4
uniprot id: A0A8J0VG05
uniprot id: A0A8J1KMW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8355:iws1.L
gene id: 8355:iws1.L
uniprot id: A0A1L8GAU9
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108711267
gene id: 8355:LOC108711267
uniprot id: A0A1L8GZS5
names: Similarity
messages: Belongs to the TCAF family.

8355:clcn2.S
gene id: 8355:clcn2.S
uniprot id: A0A1L8G3M5
uniprot id: A0A8J1KTN4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108705124
gene id: 8355:LOC108705124
uniprot id: A0A8J1MKB2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:arhgap32.L
gene id: 8355:arhgap32.L
uniprot id: A0A8J0T8E9
uniprot id: A0A8J0T9C3
uniprot id: A0A8J1L4C8
uniprot id: A0A8J1L4F1
uniprot id: Q6GPD0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PX domain-containing GAP family.
messages: Cell membrane
messages: Cytoplasm
messages: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases.
messages: Membrane
messages: The N-terminal PX domain interacts specifically with phosphatidylinositides.

8355:ubl3.L
gene id: 8355:ubl3.L
uniprot id: Q6GNJ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:rln3.S
gene id: 8355:rln3.S
uniprot id: A0A8J0TUI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

8355:LOC121398939
gene id: 8355:LOC121398939
uniprot id: A0A8J1LZL5
names: Similarity
messages: Belongs to the cyclin family.

8355:dio2.L
gene id: 8355:dio2.L
uniprot id: A0A8J0QH40
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

8355:nr1h4.L
gene id: 8355:nr1h4.L
uniprot id: A0A1L8GY13
uniprot id: A0A8J1MKC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8355:phaf1.S
gene id: 8355:phaf1.S
uniprot id: A0A1L8GEE4
names: Similarity
messages: Belongs to the PHAF1 family.

8355:tm9sf1.S
gene id: 8355:tm9sf1.S
uniprot id: A0A1L8HPG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

8355:med22.L
gene id: 8355:med22.L
uniprot id: A0A8J0T8Q1
uniprot id: A0A8J0TGJ1
uniprot id: Q6GQ95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 22 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:XB5748694.L
gene id: 8355:XB5748694.L
uniprot id: Q641G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

8355:hpse.L
gene id: 8355:hpse.L
uniprot id: A0A8J0VJ35
uniprot id: A0A8J1N051
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

8355:cab39.L
gene id: 8355:cab39.L
uniprot id: A0A8J0VDP6
uniprot id: Q6IP72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

8355:fam241b.L
gene id: 8355:fam241b.L
uniprot id: A0A1L8FK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

8355:prkch.L
gene id: 8355:prkch.L
uniprot id: Q6GNZ7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

8355:LOC108716173
gene id: 8355:LOC108716173
uniprot id: A0A8J1KRW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

8355:MGC84076
gene id: 8355:MGC84076
uniprot id: A0A8J1LKQ1
uniprot id: Q6DKC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

8355:gmnn.S
gene id: 8355:gmnn.S
uniprot id: O93352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

8355:abhd1.S
gene id: 8355:abhd1.S
uniprot id: Q32NS5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

8355:nkx3-2.L
gene id: 8355:nkx3-2.L
uniprot id: A0A1L8HTD2
names: Subcellular Location Annotation
messages: Nucleus

8355:pias1.L
gene id: 8355:pias1.L
uniprot id: A0A8J0UQU6
uniprot id: Q5XHH3
names: Similarity
messages: Belongs to the PIAS family.

8355:LOC121393613
gene id: 8355:LOC121393613
uniprot id: A0A1L8G0S1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:prickle3.L
gene id: 8355:prickle3.L
uniprot id: A0A8J1LFW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cell membrane
messages: Membrane

8355:LOC108717702
gene id: 8355:LOC108717702
uniprot id: A0A1L8G129
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8355:LOC108703507
gene id: 8355:LOC108703507
uniprot id: A0A8J0U1Z4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:nifk.S
gene id: 8355:nifk.S
uniprot id: Q7SYS2
names: Subcellular Location Annotation
messages: nucleolus

8355:LOC108710959
gene id: 8355:LOC108710959
uniprot id: A0A1L8GXS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

8355:dclre1b.L
gene id: 8355:dclre1b.L
uniprot id: A0A1L8HEY3
uniprot id: A0A8J0UHH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

8355:agtpbp1.L
gene id: 8355:agtpbp1.L
uniprot id: Q6DD21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins.
messages: Mitochondrion
messages: Nucleus
messages: cytosol

8355:LOC108699714
gene id: 8355:LOC108699714
uniprot id: A0A1L8EZS3
uniprot id: A0A8J0TF89
uniprot id: A0A8J0TLN2
uniprot id: A0A8J0TMZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

8355:LOC108717743
gene id: 8355:LOC108717743
uniprot id: A0A8J0VBP5
uniprot id: A0A8J0VK83
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

8355:LOC121401339
gene id: 8355:LOC121401339
uniprot id: A0A1L8H4L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:asz1.L
gene id: 8355:asz1.L
uniprot id: Q6JXL5
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.

8355:proz.L
gene id: 8355:proz.L
uniprot id: A0A1L8HH14
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:sugct.L
gene id: 8355:sugct.L
uniprot id: A0A1L8FWN7
uniprot id: A0A8J0VHW1
uniprot id: A0A8J0VN18
uniprot id: Q4V7H7
names: Similarity
messages: Belongs to the CoA-transferase III family.

8355:LOC121401325
gene id: 8355:LOC121401325
uniprot id: A0A8J1MJS3
names: Subcellular Location Annotation
messages: Membrane

8355:kremen2.S
gene id: 8355:kremen2.S
uniprot id: A0A8J1LVU9
uniprot id: Q8AXX3
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

8355:LOC733397
gene id: 8355:LOC733397
uniprot id: A0A8J0UDG0
uniprot id: A0A8J0UEQ3
uniprot id: A0A8J1M8B6
uniprot id: A0A8J1M8B7
uniprot id: A0A8J1M8C1
uniprot id: A0A8J1M8C2
uniprot id: A0A8J1M8C7
uniprot id: A0A8J1M8H2
uniprot id: A0A8J1M8H7
uniprot id: A0A8J1M9C6
uniprot id: A0A8J1M9D0
uniprot id: A0A8J1MA56
uniprot id: A0A8J1MA61
names: Subcellular Location Annotation
messages: Cytoplasm

8355:rabac1.S
gene id: 8355:rabac1.S
uniprot id: Q6NU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

8355:adcy7.L
gene id: 8355:adcy7.L
uniprot id: A0A8J0UVH3
uniprot id: A0A8J0V196
uniprot id: A0A8J0V534
uniprot id: A0A8J1MYH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

8355:cryba4.S
gene id: 8355:cryba4.S
uniprot id: Q7SZ91
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:ppp1cc.S
gene id: 8355:ppp1cc.S
uniprot id: Q7SZ10
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cleavage furrow
messages: Cytoplasm
messages: Midbody
messages: Mitochondrion
messages: Nucleus
messages: Nucleus speckle
messages: PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits.
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (By similarity). Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin (By similarity).
messages: kinetochore
messages: nucleolus
messages: nucleoplasm

8355:sptlc2.S
gene id: 8355:sptlc2.S
uniprot id: Q6GP36
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

8355:MGC145330.L
gene id: 8355:MGC145330.L
uniprot id: A0A1L8H0Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

8355:gpr150.L
gene id: 8355:gpr150.L
uniprot id: A0A1L8I204
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:ccdc85a.S
gene id: 8355:ccdc85a.S
uniprot id: A0A8J1KU44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

8355:sass6.L
gene id: 8355:sass6.L
uniprot id: A0A8J0UA22
uniprot id: A0A8J0UAA2
uniprot id: Q6NRG6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity).
messages: Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets.
messages: The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
messages: centrosome

8355:rabggtb.S
gene id: 8355:rabggtb.S
uniprot id: Q5EAU8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

8355:sncb.L
gene id: 8355:sncb.L
uniprot id: Q5U4S4
names: Similarity
messages: Belongs to the synuclein family.

8355:LOC108709051
gene id: 8355:LOC108709051
uniprot id: A0A1L8HBD5
names: Subcellular Location Annotation
messages: Membrane

8355:ctps1.S
gene id: 8355:ctps1.S
uniprot id: Q5XHA8
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen.

8355:gosr2.L
gene id: 8355:gosr2.L
uniprot id: A0A1L8ESM2
uniprot id: A0A8J0TUF0
uniprot id: Q6DDU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

8355:nox5.S
gene id: 8355:nox5.S
uniprot id: A0A8J0UN60
names: Subcellular Location Annotation
messages: Membrane

8355:ssr2.S
gene id: 8355:ssr2.S
uniprot id: Q98SP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

8355:LOC121394638
gene id: 8355:LOC121394638
uniprot id: A0A8J1KZA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:LOC108703423
gene id: 8355:LOC108703423
uniprot id: A0A8J1MPK2
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108702365
gene id: 8355:LOC108702365
uniprot id: A0A1L8EKY2
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8355:LOC121398884
gene id: 8355:LOC121398884
uniprot id: A0A8J1M074
names: Similarity
messages: Belongs to the TPX2 family.

8355:limch1.L
gene id: 8355:limch1.L
uniprot id: Q3KQW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.
messages: Belongs to the LIMCH1 family.
messages: stress fiber

8355:kmt2d.S
gene id: 8355:kmt2d.S
uniprot id: A0A8J1MG41
names: Subcellular Location Annotation
messages: Nucleus

8355:creb5.S
gene id: 8355:creb5.S
uniprot id: A0A8J0VMV0
uniprot id: A0A8J1L1P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

8355:fut8.L
gene id: 8355:fut8.L
uniprot id: Q8AXS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
messages: Golgi stack membrane
messages: Membrane

8355:nt5c3b.L
gene id: 8355:nt5c3b.L
uniprot id: A0A8J1LPK7
uniprot id: Q2TAG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm
messages: Monomer.
messages: Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity).

8355:tspan12.L
gene id: 8355:tspan12.L
uniprot id: A0A1L8GYZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:jak2.S
gene id: 8355:jak2.S
uniprot id: A0A8J1M2Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system
messages: Nucleus

8355:ptx.S
gene id: 8355:ptx.S
uniprot id: A0A8J1MZ50
uniprot id: A0A8J1N113
uniprot id: A0A8J1N1T5
uniprot id: Q2LK77
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:relb.L
gene id: 8355:relb.L
uniprot id: A0A1L8F873
names: Subcellular Location Annotation
messages: Nucleus

8355:id2.L
gene id: 8355:id2.L
uniprot id: Q9PWJ5
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Maternal expression declines during cleavage and blastula stages with zygotic expression increasing from gastrulation. From neurula stage onwards, expression levels are relatively constant.
messages: Heterodimer with other HLH proteins.
messages: In the embryo, expressed in a range of tissues, with primary expression in the developing pronephros; expressed in the pronephric anlage, and by the swimming tadpole stages expressed robustly in the pronephric tubules and weakly in the pronephric duct. Expressed in the secondary heart field. In the developing nervous system, expressed in the neural crest and in the neural folds during neurula stages, and at stage 20 in the neural tube, ventral mesoderm and mid-hindbrain boundary. By early tailbud stages, expressed in the neural tube, somites and branchial arches. In tadpoles (stage 37/38), expressed in the heart, eye, otic vesicle, somites and branchial arches. Also expressed in migrating muscle cells. Expressed at a low level in limbs, with expression decreasing as limbs develop, but expressed at a high level in blastemas (regenerated limbs), where expression is localized primarily to the blastemal epidermis. Widely expressed in adults with highest expression in the spleen, skin, intestine and brain, and at a much lower level in testis and heart.
messages: May be induced by Notch signaling.
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Inhibits the activity of both neurogenic (neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors. May play a role in the regulation of the circadian clock.

8355:psmb9.S
gene id: 8355:psmb9.S
uniprot id: A0A8J0TN56
uniprot id: A0A8J1LL50
uniprot id: O12999
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:adam28.1.S
gene id: 8355:adam28.1.S
uniprot id: A0A8J0UP88
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108718626
gene id: 8355:LOC108718626
uniprot id: A0A8J1L126
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

8355:LOC108698994
gene id: 8355:LOC108698994
uniprot id: A0A1L8FBA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:nusap1.L
gene id: 8355:nusap1.L
uniprot id: A0A1L8FB29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUSAP family.
messages: Cytoplasm

8355:rhbdl1.S
gene id: 8355:rhbdl1.S
uniprot id: Q6GLW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Membrane

8355:gba3.L
gene id: 8355:gba3.L
uniprot id: Q66J37
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

8355:etnppl.L
gene id: 8355:etnppl.L
uniprot id: Q6DEB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.
messages: Does not seem to possess aminotransferase activity.
messages: Homotetramer.
messages: Mitochondrion

8355:LOC108716413
gene id: 8355:LOC108716413
uniprot id: A0A1L8G5V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8355:msln.L
gene id: 8355:msln.L
uniprot id: A0A1L8EYM9
names: Similarity
messages: Belongs to the mesothelin family.

8355:kif1b.S
gene id: 8355:kif1b.S
uniprot id: A0A1L8FFA7
uniprot id: A0A1L8FFC2
uniprot id: A0A8J0TC92
uniprot id: A0A8J0TF16
uniprot id: A0A8J0TFN9
uniprot id: A0A8J0TFP5
uniprot id: A0A8J1LCA2
uniprot id: A0A8J1LCC6
uniprot id: A0A8J1LCH4
uniprot id: A0A8J1LDV8
uniprot id: A0A8J1LET1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Homodimer.
messages: axon

8355:tmem132c.S
gene id: 8355:tmem132c.S
uniprot id: A0A1L8HQJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

8355:ppa1.L
gene id: 8355:ppa1.L
uniprot id: A0A1L8HUY4
uniprot id: A0A8J1MYH1
names: Similarity
messages: Belongs to the PPase family.

8355:LOC121397079
gene id: 8355:LOC121397079
uniprot id: A0A8J1LIN1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

8355:slc26a2.S
gene id: 8355:slc26a2.S
uniprot id: A0A1L8GV50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

8355:LOC121397312
gene id: 8355:LOC121397312
uniprot id: A0A8J1LMB2
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rho.2.L
gene id: 8355:rho.2.L
uniprot id: P29403
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.
messages: Membrane
messages: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
messages: photoreceptor outer segment

8355:dlgap5.S
gene id: 8355:dlgap5.S
uniprot id: A0A8J0TFE0
uniprot id: A0A8J0TLT8
uniprot id: A0A8J0TQ27
names: Similarity
messages: Belongs to the SAPAP family.

8355:epn1.L
gene id: 8355:epn1.L
uniprot id: A0A1L8FMW0
uniprot id: A0A8J0T322
uniprot id: A0A8J0T329
uniprot id: A0A8J0T333
uniprot id: A0A8J0T9G8
uniprot id: A0A8J0T9H3
uniprot id: A0A8J0TBH0
uniprot id: A0A8J0TBH5
uniprot id: A0A8J0TBI0
uniprot id: A0A8J0TBY7
uniprot id: A0A8J0TBZ3
uniprot id: A0A8J0TCQ4
uniprot id: A0A8J1L7A0
uniprot id: A0A8J1L8X1
names: Similarity
messages: Belongs to the epsin family.

8355:tpm1.L
gene id: 8355:tpm1.L
uniprot id: Q01173
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
messages: Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

8355:LOC108711609
gene id: 8355:LOC108711609
uniprot id: A0A1L8H210
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

8355:pes1.S
gene id: 8355:pes1.S
uniprot id: Q7ZY69
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the PeBoW complex, composed of bop1, pes1 and wdr12. The complex is held together by bop1, which interacts with pes1 via its N-terminal domain and with wdr12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (By similarity). Required for neural crest migration and eye development.
messages: Maternally expressed. Strongly expressed in the anterior neural plate at stage 18. Expressed in the migrating cranial neural crest and the developing eye at stage 23. Also expressed in the midbrain-hindbrain boundary, migrating neural crest cells and the periocular mesenchyme at stages 26-31. Expression appears to require Wnt-4 activity.
messages: nucleolus
messages: nucleoplasm

8355:aspn.S
gene id: 8355:aspn.S
uniprot id: A0A1L8GH88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

8355:tnfsf15.S
gene id: 8355:tnfsf15.S
uniprot id: A0A8J0TQA7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:LOC108718582
gene id: 8355:LOC108718582
uniprot id: A0A8J1KYI5
uniprot id: A0A8J1L053
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Interacts with atp1b1 C-terminus.
messages: Membrane

8355:comt.L
gene id: 8355:comt.L
uniprot id: Q7ZWI8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.

8355:hes2.L
gene id: 8355:hes2.L
uniprot id: Q00P32
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Differentially regulated in the ectoderm and neuroectoderm by notch and neurog2/ngnr1.
messages: Expressed both maternally and zygotically.
messages: Expressed in the animal half of the early cleavage stage embryo. During neurulation and organogenesis, the otic vesicles and retina are the main sites of expression; expression in otic placodes begins as early as stage 13.5, persisting in the otic vesicles at stage 30 and beyond. Also transiently expressed in the olfactory placodes. In addition, weakly expressed in primary neurons. Expression in the retina begins at stage 21, and is seen throughout the neural retina by stage 30. From stage 35 onwards, expression progressively declines in the central retina, while remaining high in the margins. At stage 41, expression becomes restricted to the ciliary marginal zone (CMZ) of the retina, the only region where retinogenesis is still occurring.
messages: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
messages: Nucleus
messages: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family (By similarity). Homodimer, and heterodimer with the other bHLH proteins neurod1, neurod4/ath3, hes1/hairy1 and hes6r. Weakly interacts with the bHLH protein hey1/hrt1.
messages: Transcriptional repressor. Essential in the retina to govern glial versus neuronal differentiation. Promotes gliogenesis through the inhibition of neuronal differentiation by at least two distinct mechanisms; represses proneural gene transcription, and also physically interacts with proneural proteins, including neurod1.

8355:cct4.S
gene id: 8355:cct4.S
uniprot id: Q5XGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

8355:anapc16.L
gene id: 8355:anapc16.L
uniprot id: A0A1L8FJU3
uniprot id: Q6GQ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: The APC/C is composed of at least 12 subunits. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11 (By similarity).
messages: kinetochore

8355:LOC108711608
gene id: 8355:LOC108711608
uniprot id: A0A1L8H289
uniprot id: A0A8J0UL14
uniprot id: A0A8J0UT69
names: Subcellular Location Annotation
messages: Membrane

8355:ergic3.L
gene id: 8355:ergic3.L
uniprot id: A0A8J0TRH9
uniprot id: Q66KH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.
messages: Possible role in transport between endoplasmic reticulum and Golgi.
messages: cis-Golgi network membrane

8355:astl2g.L
gene id: 8355:astl2g.L
uniprot id: A0A1L8GIT9
uniprot id: A0A8J1MXN1
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ubr2.S
gene id: 8355:ubr2.S
uniprot id: A0A8J1KRN0
uniprot id: A0A8J1KTC0
uniprot id: Q498F1
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

8355:hal.2.L
gene id: 8355:hal.2.L
uniprot id: Q0VGW8
names: Similarity
messages: Belongs to the PAL/histidase family.

8355:pum2.L
gene id: 8355:pum2.L
uniprot id: E3WDQ9
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Component of a complex with papd4, sympk, tacc3, parn, dazl and cpeb1 (PubMed:21098481).
messages: Cytoplasm
messages: Cytoplasmic granule
messages: P-body
messages: Phosphorylated.
messages: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (PubMed:21098481). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs.
messages: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. RNA-binding occurs on the concave side of the surface. Pum2 is composed of 8 pumilio repeats of 36 residues; each repeat binds a single nucleotide in its RNA target. Residues at positions 12 and 16 of the pumilio repeat bind each RNA base via hydrogen bonding or van der Waals contacts with the Watson-Crick edge, while the amino acid at position 13 makes a stacking interaction. The recognition of RNA by pumilio repeats is base specific: cysteine and glutamine at position 12 and 16, respectively, bind adenine; asparagine and glutamine bind uracil; and serine and glutamate bind guanine.

8355:LOC121399877
gene id: 8355:LOC121399877
uniprot id: A0A8J1M7P1
uniprot id: A0A8J1M7T5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:zer1.S
gene id: 8355:zer1.S
uniprot id: Q6PF36
names: Similarity
messages: Belongs to the zyg-11 family.

8355:gng5.S
gene id: 8355:gng5.S
uniprot id: Q6DKM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:LOC100192369
gene id: 8355:LOC100192369
uniprot id: B4XAK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:LOC108719104
gene id: 8355:LOC108719104
uniprot id: A0A1L8FXP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

8355:clk2.S
gene id: 8355:clk2.S
uniprot id: A0A1L8F5A6
uniprot id: A0A8J0TEI8
uniprot id: Q7ZY59
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:rabac1.L
gene id: 8355:rabac1.L
uniprot id: A0A8J1L7A9
uniprot id: Q640E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

8355:gdf2.L
gene id: 8355:gdf2.L
uniprot id: A0A1L8FKQ2
names: Similarity
messages: Belongs to the TGF-beta family.

8355:LOC121402881
gene id: 8355:LOC121402881
uniprot id: A0A8J1MX23
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:fnbp1l.L
gene id: 8355:fnbp1l.L
uniprot id: A0A1L8GMY4
uniprot id: A0A8J0UZK1
uniprot id: Q2TAF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

8355:kif22.S
gene id: 8355:kif22.S
uniprot id: Q9I869
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: First detected at germinal vesicle breakdown in maturing oocytes (at protein level).
messages: Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA.
messages: Nucleus
messages: Ubiquitinated, leading to its subsequent proteasomal degradation.
messages: cytoskeleton

8355:LOC108714363
gene id: 8355:LOC108714363
uniprot id: A0A1L8GMP0
uniprot id: A0A8J0V2D2
uniprot id: A0A8J0V2R0
uniprot id: A0A8J0V6L7
uniprot id: A0A8J1MYB2
uniprot id: A0A8J1MZM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

8355:hrh3.S
gene id: 8355:hrh3.S
uniprot id: A0A1L8ELK7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:fth1.1.L
gene id: 8355:fth1.1.L
uniprot id: Q6PAB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8355:efnb3.L
gene id: 8355:efnb3.L
uniprot id: A0A8J0UEV3
uniprot id: A0A8J0ULJ5
uniprot id: A0A8J0UMV5
uniprot id: Q9PT69
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rnaseh1.S
gene id: 8355:rnaseh1.S
uniprot id: A0A8J1KRI8
uniprot id: A0A8J1KUK9
uniprot id: Q6NU65
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

8355:fscn2.L
gene id: 8355:fscn2.L
uniprot id: B2LT51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

8355:LOC108714181
gene id: 8355:LOC108714181
uniprot id: A0A1L8GLM1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121402224
gene id: 8355:LOC121402224
uniprot id: A0A8J1MSH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:gar1.S
gene id: 8355:gar1.S
uniprot id: A0A1L8HLZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

8355:saraf.L
gene id: 8355:saraf.L
uniprot id: A0A1L8HVI4
uniprot id: A0A8J0UV92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:prdm12.L
gene id: 8355:prdm12.L
uniprot id: Q7T0V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Involved in the positive regulation of histone H3-K9 dimethylation.
messages: Nucleus

8355:ptprt.L
gene id: 8355:ptprt.L
uniprot id: A0A8J1LU98
uniprot id: A0A8J1LUA2
uniprot id: A0A8J1LUA7
uniprot id: A0A8J1LUV3
uniprot id: A0A8J1LUV8
uniprot id: A0A8J1LVP5
uniprot id: A0A8J1LVQ0
uniprot id: A0A8J1LWK4
uniprot id: A0A8J1LWK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

8355:n4bp1.L
gene id: 8355:n4bp1.L
uniprot id: Q7ZXG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP1 family.
messages: Nucleus
messages: PML body
messages: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (By similarity). Has ribonuclease activity (By similarity).
messages: cytosol
messages: nucleolus

8355:gemin2.S
gene id: 8355:gemin2.S
uniprot id: A0A8J0Q0J7
uniprot id: Q6DDI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

8355:eml1.S
gene id: 8355:eml1.S
uniprot id: A0A8J0TEZ1
uniprot id: A0A8J0TMQ6
uniprot id: Q5U577
names: Similarity
messages: Belongs to the WD repeat EMAP family.

8355:cacna1s.S
gene id: 8355:cacna1s.S
uniprot id: A0A1L8H6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

8355:LOC108697216
gene id: 8355:LOC108697216
uniprot id: A0A1L8FF79
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

8355:LOC108716506
gene id: 8355:LOC108716506
uniprot id: A0A8J0VA96
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.
messages: Cell membrane
messages: Membrane

8355:spi1.L
gene id: 8355:spi1.L
uniprot id: A0A8J0UZB5
uniprot id: A0A8J0V0H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:lmnb1.L
gene id: 8355:lmnb1.L
uniprot id: Q8AVZ3
names: Similarity
messages: Belongs to the intermediate filament family.

8355:cd40lg.S
gene id: 8355:cd40lg.S
uniprot id: A0A1L8F3A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

8355:erf.L
gene id: 8355:erf.L
uniprot id: A0A1L8FN14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:slc39a8.S
gene id: 8355:slc39a8.S
uniprot id: A0A1L8HM75
names: Subcellular Location Annotation
messages: Membrane

8355:egr1.L
gene id: 8355:egr1.L
uniprot id: Q6GQH4
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine.
messages: By dorsalizing and ventralizing growth factors during mesoderm induction. Responds to the FGF-induced MAPK/Ets-serum response factor (srf-elk1)-signaling pathway. Induced by activin and bmp4 acting indirectly via an FGF-signaling pathway. Induced in response to wound-induced activation of the MAPK pathway. Induced by both t/bra and foxa4/pintallavis alone, with maximal activation requiring both transcription factors. Induction by t/bra is indirect and probably occurs via the FGF-signaling pathway, whereas induction by foxa4/pintallavis may be direct.
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Expressed at a low level maternally, with expression strongly increasing with the onset of gastrulation, then decreasing again in later stages of embryonic development with expression undetectable during neurulation. Expressed in adults.
messages: Expressed in the presumptive mesoderm. In blastula embryos, expressed in the dorsal marginal zone, and at the onset of gastrulation expression is specific to the Spemann organizer. As gastrulation proceeds, expressed in a ring around the yolk plug. This expression is maintained in advanced gastrulae, with weak expression also extending into the dorsal midline. By the neurula stage, expression is excluded from the notochord. In late tailbud stages, expressed in two spots in the anterior forebrain, which are connected via a bridge of cells that also show expression.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays a role in regulating the expression of circadian clock genes (By similarity).

8355:LOC108717143
gene id: 8355:LOC108717143
uniprot id: A0A8J0VCC1
names: Similarity
messages: Belongs to the apolipoprotein L family.

8355:capn8.1.S
gene id: 8355:capn8.1.S
uniprot id: A0A8J1KS88
uniprot id: A0A8J1KS94
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:parva.L
gene id: 8355:parva.L
uniprot id: A0A1L8GIH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

8355:tmem106c.L
gene id: 8355:tmem106c.L
uniprot id: A0A1L8HIE8
names: Similarity
messages: Belongs to the TMEM106 family.

8355:LOC101243550
gene id: 8355:LOC101243550
uniprot id: A0A1L8H3Q9
uniprot id: A0A8J1MGX6
uniprot id: L7T0Q5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:rin2.S
gene id: 8355:rin2.S
uniprot id: A0A1L8G1L7
uniprot id: A0A8J0VKC3
uniprot id: A0A8J1KSJ8
uniprot id: A0A8J1KSJ9
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

8355:ctso.L
gene id: 8355:ctso.L
uniprot id: A0A1L8HUA0
uniprot id: A0A8J0TJN2
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:LOC121394141
gene id: 8355:LOC121394141
uniprot id: A0A8J1KRY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:slc30a7.L
gene id: 8355:slc30a7.L
uniprot id: Q6NRI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Homooligomer.
messages: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis (By similarity).
messages: trans-Golgi network membrane

8355:LOC108717613
gene id: 8355:LOC108717613
uniprot id: A0A8J0VJN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:rps19.L
gene id: 8355:rps19.L
uniprot id: A0A1L8FNR9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

8355:eogt.L
gene id: 8355:eogt.L
uniprot id: A0A8J1MUS4
uniprot id: Q6GQ23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
messages: Endoplasmic reticulum lumen

8355:LOC121393847
gene id: 8355:LOC121393847
uniprot id: A0A8J1KQC5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:ube4a.S
gene id: 8355:ube4a.S
uniprot id: Q4FZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

8355:LOC108711753
gene id: 8355:LOC108711753
uniprot id: A0A1L8H3D8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:rrp15.L
gene id: 8355:rrp15.L
uniprot id: A0A1L8G6I5
uniprot id: A0A8J0VF01
names: Similarity
messages: Belongs to the RRP15 family.

8355:LOC108705417
gene id: 8355:LOC108705417
uniprot id: A0A8J0U6W1
names: Subcellular Location Annotation
messages: Membrane

8355:eef2k.L
gene id: 8355:eef2k.L
uniprot id: A0A1L8EY00
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

8355:sorbs3.L
gene id: 8355:sorbs3.L
uniprot id: A0A1L8H226
uniprot id: A0A8J0UT41
uniprot id: A0A8J1MNF1
names: Subcellular Location Annotation
messages: focal adhesion

8355:bola2.L
gene id: 8355:bola2.L
uniprot id: Q6GN90
names: Similarity
messages: Belongs to the BolA/IbaG family.

8355:tcp11l2.L
gene id: 8355:tcp11l2.L
uniprot id: A0A1L8GY49
uniprot id: A0A8J0UQM0
names: Similarity
messages: Belongs to the TCP11 family.

8355:nipsnap3a.S
gene id: 8355:nipsnap3a.S
uniprot id: Q6PA66
names: Similarity
messages: Belongs to the NipSnap family.

8355:bicc1.L
gene id: 8355:bicc1.L
uniprot id: A0A8J1L4L4
uniprot id: Q5U4T7
names: Function
names: Similarity
messages: Belongs to the BicC family.
messages: Putative RNA-binding protein. May be involved in regulating gene expression during embryonic development. Seems to be involved in endoderm formation. Ectopic expression results in endoderm formation in the absence of mesoderm induction (By similarity).

8355:ywhah.L
gene id: 8355:ywhah.L
uniprot id: Q6DJE2
names: Function
names: Similarity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
messages: Belongs to the 14-3-3 family.

8355:ina.S
gene id: 8355:ina.S
uniprot id: P79933
names: Similarity
messages: Belongs to the intermediate filament family.

8355:actr3.L
gene id: 8355:actr3.L
uniprot id: A0A1L8EV45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the actin family. ARP3 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Nucleus
messages: cytoskeleton

8355:LOC108719987
gene id: 8355:LOC108719987
uniprot id: A0A1L8FRL0
names: Similarity
messages: Belongs to the copine family.

8355:cbr1.2.L
gene id: 8355:cbr1.2.L
uniprot id: A0A1L8HCI6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:slc18a3.S
gene id: 8355:slc18a3.S
uniprot id: A0A8J0TUC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Membrane

8355:med4.S
gene id: 8355:med4.S
uniprot id: A0A8J1MDI0
uniprot id: Q5XG48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:rpl22l1.L
gene id: 8355:rpl22l1.L
uniprot id: A1L1C1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

8355:LOC108699878
gene id: 8355:LOC108699878
uniprot id: A0A8J1LLF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:tbxt.2.S
gene id: 8355:tbxt.2.S
uniprot id: Q9W7R8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:naa30.L
gene id: 8355:naa30.L
uniprot id: A0A1L8FAC3
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

8355:cox7a2l.L
gene id: 8355:cox7a2l.L
uniprot id: A0A8J0VAT2
uniprot id: Q2VPF0
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

8355:bmpr1b.L
gene id: 8355:bmpr1b.L
uniprot id: A0A1L8HV56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8355:LOC108705049
gene id: 8355:LOC108705049
uniprot id: A0A8J1LDJ7
names: Subcellular Location Annotation
messages: Membrane

8355:plin1.L
gene id: 8355:plin1.L
uniprot id: A0A8J0UVT8
names: Similarity
messages: Belongs to the perilipin family.

8355:LOC108707597
gene id: 8355:LOC108707597
uniprot id: A0A1L8HJN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:stard9.L
gene id: 8355:stard9.L
uniprot id: A0A1L8FAG1
uniprot id: A0A8J1LI70
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ift20.S
gene id: 8355:ift20.S
uniprot id: A0A1L8H621
uniprot id: Q640Z7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus
messages: Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella.
messages: centriole
messages: cilium
messages: cis-Golgi network

8355:LOC108708891
gene id: 8355:LOC108708891
uniprot id: A0A1L8H644
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cyrib.S
gene id: 8355:cyrib.S
uniprot id: A0A1L8FTU6
uniprot id: A0A8J0T7J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

8355:LOC108719855
gene id: 8355:LOC108719855
uniprot id: A0A1L8FQR6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:dtna.S
gene id: 8355:dtna.S
uniprot id: A0A8J0VIT1
uniprot id: A0A8J0VL12
uniprot id: A0A8J0VL16
uniprot id: A0A8J0VM68
uniprot id: A0A8J0VM71
uniprot id: A0A8J0VPU2
uniprot id: A0A8J0VPU3
uniprot id: A0A8J1L0G8
uniprot id: A0A8J1L0H2
uniprot id: A0A8J1L0H5
uniprot id: A0A8J1L0H6
uniprot id: A0A8J1L0I1
uniprot id: A0A8J1L219
uniprot id: A0A8J1L224
uniprot id: A0A8J1L393
uniprot id: A0A8J1L398
uniprot id: Q6NU81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

8355:smarcd2.L
gene id: 8355:smarcd2.L
uniprot id: A0A1L8ESL3
names: Similarity
messages: Belongs to the SMARCD family.

8355:fam83e.S
gene id: 8355:fam83e.S
uniprot id: A0A1L8FHA1
names: Similarity
messages: Belongs to the FAM83 family.

8355:LOC108712234
gene id: 8355:LOC108712234
uniprot id: A0A8J0UMU9
uniprot id: A0A8J0UTJ6
uniprot id: A0A8J0UUP7
uniprot id: A0A8J0UUS5
uniprot id: A0A8J1KJ39
uniprot id: A0A8J1KJ46
uniprot id: A0A8J1KJ72
uniprot id: A0A8J1KJ81
uniprot id: A0A8J1KKS7
uniprot id: A0A8J1KM91
uniprot id: A0A8J1KMB1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

8355:lyn.L
gene id: 8355:lyn.L
uniprot id: A0A1L8FZ11
uniprot id: O13064
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:smad4.L
gene id: 8355:smad4.L
uniprot id: Q9W639
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8355:clec16a.L
gene id: 8355:clec16a.L
uniprot id: A0A1L8EXF6
uniprot id: A0A8J0TVS6
uniprot id: A0A8J0TYE5
uniprot id: A0A8J1LTN5
uniprot id: A0A8J1LTQ1
uniprot id: A0A8J1LV51
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

8355:comp.L
gene id: 8355:comp.L
uniprot id: A0A8J1KNT2
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108695868
gene id: 8355:LOC108695868
uniprot id: A0A1L8FMR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108704030
gene id: 8355:LOC108704030
uniprot id: A0A8J0U4F5
uniprot id: A0A8J1MYF9
uniprot id: A0A8J1MYQ1
uniprot id: A0A8J1N102
names: Similarity
messages: Belongs to the BicD family.

8355:LOC108708084
gene id: 8355:LOC108708084
uniprot id: A0A1L8HE60
names: Similarity
messages: Belongs to the themis family.

8355:ss18l2.L
gene id: 8355:ss18l2.L
uniprot id: Q5M987
names: Similarity
messages: Belongs to the SS18 family.

8355:cyp7b1.L
gene id: 8355:cyp7b1.L
uniprot id: A0A8J0VPB7
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:sntb1.L
gene id: 8355:sntb1.L
uniprot id: A0A1L8FZY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

8355:krt78.4.L
gene id: 8355:krt78.4.L
uniprot id: A0A1L8HIL0
names: Similarity
messages: Belongs to the intermediate filament family.

8355:mpped2.L
gene id: 8355:mpped2.L
uniprot id: A0A1L8GJ15
names: Similarity
messages: Belongs to the UPF0046 family.

8355:zic3.L
gene id: 8355:zic3.L
uniprot id: A0A1L8F822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

8355:LOC108704546
gene id: 8355:LOC108704546
uniprot id: A0A8J0U7P0
uniprot id: A0A8J1MA41
names: Similarity
messages: Belongs to the peptidase A1 family.

8355:gatm.S
gene id: 8355:gatm.S
uniprot id: A0A1L8GSU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

8355:LOC108710636
gene id: 8355:LOC108710636
uniprot id: A0A1L8H2F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121401499
gene id: 8355:LOC121401499
uniprot id: A0A8J1MLH8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:sybu.L
gene id: 8355:sybu.L
uniprot id: A0A1L8FZT7
uniprot id: A0A8J0VKM0
names: Subcellular Location Annotation
messages: Membrane

8355:hnrnpu.L
gene id: 8355:hnrnpu.L
uniprot id: A0A1L8G7R5
uniprot id: A0A8J0PSM9
uniprot id: A0A8J1KL44
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108702366
gene id: 8355:LOC108702366
uniprot id: A0A1L8EL15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:fbxo43.L
gene id: 8355:fbxo43.L
uniprot id: Q8AXF4
names: Developmental Stage
names: Function
names: PTM
names: Sequence Caution
names: Subunit
messages: Accumulates during oocyte maturation.
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (PubMed:15713843). Interaction with SKP1 does not occur (By similarity).
messages: Phosphorylated on Thr-195 by CaMK2 in response to calcium during egg activation, which promotes subsequent phosphorylation by PLK1, ubiquitination and protesomal degradation.
messages: Required to prevent anaphase onset in cytostatic factor-arrested oocytes. Inhibits the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase and prevents cyclin degradation. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
messages: Sequencing errors.
messages: Ubiquitinated by FBXW1 during egg activation, which promotes proteasomal degradation.

8355:ssh1.L
gene id: 8355:ssh1.L
uniprot id: A0A1L8HZX2
uniprot id: A0A8J0V7I2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

8355:aktip.L
gene id: 8355:aktip.L
uniprot id: Q498F8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.
messages: May function to promote vesicle trafficking and/or fusion. May also regulate apoptosis (By similarity).

8355:mmp3.L
gene id: 8355:mmp3.L
uniprot id: Q6DCN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Secreted

8355:LOC108696223
gene id: 8355:LOC108696223
uniprot id: A0A1L8FJS0
uniprot id: A0A8J1L5D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8355:psmc6.S
gene id: 8355:psmc6.S
uniprot id: Q4QR39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

8355:slc46a3.L
gene id: 8355:slc46a3.L
uniprot id: A0A1L8HIZ5
uniprot id: A0A8J1MAG2
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108704863
gene id: 8355:LOC108704863
uniprot id: A0A8J0U5M7
names: Subcellular Location Annotation
messages: Nucleus

8355:pax8.L
gene id: 8355:pax8.L
uniprot id: A0A1L8H1M7
uniprot id: A0A8J0ULY5
uniprot id: A0A8J0UN77
uniprot id: A0A8J0UN82
uniprot id: A0A8J0UN95
uniprot id: A0A8J0UR86
uniprot id: Q9PUK5
names: Caution
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By retinoic acid in combination with activin.
messages: Expression starts at late gastrula stages in cells fated to become the primordia of the otic system and the pronephric kidney. Expression is maintained in these two structures through late tailbud stages. Does not appear to be expressed in the thyroid gland.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Probable transcription factor. Involved in kidney development, acting synergistically with lhx1/lim-1 to establish the pronephric primordium in late gastrulae/early neurulae.

8355:LOC108716937
gene id: 8355:LOC108716937
uniprot id: A0A8J0VBF7
uniprot id: A0A8J1KQW4
names: Similarity
messages: Belongs to the SAPAP family.

8355:LOC121393384
gene id: 8355:LOC121393384
uniprot id: A0A8J1KKC7
names: Similarity
messages: Belongs to the filamin family.

8355:crygdl.13.S
gene id: 8355:crygdl.13.S
uniprot id: A0A8J0U614
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:pak3.L
gene id: 8355:pak3.L
uniprot id: Q8AXB4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Expressed from the egg to the tailbud stage embryo. Expressed at late gastrula/early neurula stages of development within the posterior neuroectoderm. Expressed in primary neurons as they differentiate in the neural plate at stage 14.5 in the area of the trigeminal placodes. Expressed in the cement gland at stage 17. Expressed during later phases in the notochord in tissues derived from dorsolateral cranial placodes.
messages: Morpholino knockdown of the protein causes inhibition of neuronal differentiation and an accumulation of neuronal progenitor cells in the anterior neural plate.
messages: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways. Involved in early neuronal development; required for cell cycle exit and differentiation of primary neurons. May be required for the formation of dendritic spines and excitatory synapses (By similarity). Cooperates synergistically with mturn to promote primary neural differentiation within the neural plate. Involved in the cement gland formation.
messages: Up-regulated by the proneural transcription factors Neurog2, Neurod1 and Ebf3. Down-regulated by the Notch pathway.

8355:cox17.L
gene id: 8355:cox17.L
uniprot id: Q5U537
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

8355:LOC108695212
gene id: 8355:LOC108695212
uniprot id: A0A1L8FRT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

8355:LOC121396931
gene id: 8355:LOC121396931
uniprot id: A0A8J1LIL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8355:enkd1.L
gene id: 8355:enkd1.L
uniprot id: A0A1L8GK81
uniprot id: A0A8J0UVE2
names: Subcellular Location Annotation
messages: cilium axoneme

8355:ccn1l.L
gene id: 8355:ccn1l.L
uniprot id: Q6IR79
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC108706080
gene id: 8355:LOC108706080
uniprot id: A0A8J1M7H8
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108716775
gene id: 8355:LOC108716775
uniprot id: A0A1L8G8W8
names: Similarity
messages: Belongs to the LCA5 family.

8355:tnrc6b.S
gene id: 8355:tnrc6b.S
uniprot id: A0A1L8GH02
uniprot id: A0A8J1KJQ7
uniprot id: A0A8J1KJQ8
uniprot id: A0A8J1KJR2
uniprot id: A0A8J1KJS1
uniprot id: A0A8J1KJS5
uniprot id: A0A8J1KLF0
names: Similarity
messages: Belongs to the GW182 family.

8355:ppfibp2.L
gene id: 8355:ppfibp2.L
uniprot id: Q6DCK5
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

8355:zadh2.S
gene id: 8355:zadh2.S
uniprot id: Q498I7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

8355:arf6.2.L
gene id: 8355:arf6.2.L
uniprot id: Q6DE46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

8355:gtf2b.S
gene id: 8355:gtf2b.S
uniprot id: A0A8J1N2B9
uniprot id: Q63ZH4
names: Similarity
messages: Belongs to the TFIIB family.

8355:atg12.S
gene id: 8355:atg12.S
uniprot id: A0A1L8FGU7
uniprot id: A8E622
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

8355:LOC121396360
gene id: 8355:LOC121396360
uniprot id: A0A8J1LDR2
names: Subcellular Location Annotation
messages: Membrane

8355:rasgrp1.L
gene id: 8355:rasgrp1.L
uniprot id: A0A1L8FAU4
uniprot id: A0A8J0T8J9
uniprot id: A0A8J0TGD9
uniprot id: A0A8J0TH95
names: Similarity
messages: Belongs to the RASGRP family.

8355:LOC108714099
gene id: 8355:LOC108714099
uniprot id: A0A8J1MWH8
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108714161
gene id: 8355:LOC108714161
uniprot id: A0A1L8GLH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

8355:rpl3l.S
gene id: 8355:rpl3l.S
uniprot id: A0A8J0U1A8
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

8355:atp6ap1.1.L
gene id: 8355:atp6ap1.1.L
uniprot id: A0A8J0UET6
uniprot id: D2WPH1
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

8355:pcyox1.L
gene id: 8355:pcyox1.L
uniprot id: A0A1L8H1E6
uniprot id: A0A8J0UKT6
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

8355:rpl29.L
gene id: 8355:rpl29.L
uniprot id: Q7SZA5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

8355:g6pc3.1.L
gene id: 8355:g6pc3.1.L
uniprot id: A0A1L8ES86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

8355:arhgef1.S
gene id: 8355:arhgef1.S
uniprot id: A0A8J0T793
uniprot id: A0A8J0TF55
uniprot id: A0A8J0TF59
uniprot id: A0A8J0TFZ4
uniprot id: A0A8J0TFZ9
uniprot id: A0A8J0TGP0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

8355:cyb561.L
gene id: 8355:cyb561.L
uniprot id: Q6GMD4
uniprot id: Q6NRZ7
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

8355:aldh5a1.L
gene id: 8355:aldh5a1.L
uniprot id: A0A1L8FY56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

8355:fam124a.S
gene id: 8355:fam124a.S
uniprot id: A0A8J0UE07
uniprot id: A0A8J0UM02
names: Similarity
messages: Belongs to the FAM124 family.

8355:ahsa1.L
gene id: 8355:ahsa1.L
uniprot id: Q6GQ65
names: Similarity
messages: Belongs to the AHA1 family.

8355:sgcd.S
gene id: 8355:sgcd.S
uniprot id: A0A8J1MSB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

8355:LOC108719555
gene id: 8355:LOC108719555
uniprot id: A0A1L8FUK5
uniprot id: A0A8J0VIH0
uniprot id: A0A8J0VKT9
uniprot id: A0A8J0VPP7
names: Subcellular Location Annotation
messages: Nucleus

8355:thrap3.L
gene id: 8355:thrap3.L
uniprot id: A0A1L8HE45
uniprot id: A0A8J0U682
uniprot id: A0A8J0UEF0
uniprot id: A0A8J0UEJ1
uniprot id: A0A8J0UH34
uniprot id: A0A8J1M9U6
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

8355:adgre5.L
gene id: 8355:adgre5.L
uniprot id: A0A8J1MMX5
uniprot id: A0A8J1MQ05
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:rps15.L
gene id: 8355:rps15.L
uniprot id: P20342
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

8355:npm3.S
gene id: 8355:npm3.S
uniprot id: Q66L02
names: Similarity
messages: Belongs to the nucleoplasmin family.

8355:rbbp8.S
gene id: 8355:rbbp8.S
uniprot id: A0A8J1L2K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

8355:khsrp.S
gene id: 8355:khsrp.S
uniprot id: A0A8J0U2Y3
uniprot id: Q8AX85
names: Subcellular Location Annotation
messages: Nucleus

8355:polr2j.L
gene id: 8355:polr2j.L
uniprot id: Q5M778
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

8355:st3gal-iii
gene id: 8355:st3gal-iii
uniprot id: A0A1L8GM36
uniprot id: A0A8J1MT80
uniprot id: A0A8J1MUM0
uniprot id: A0A8J1MVI7
uniprot id: B7ZQA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:marchf4.S
gene id: 8355:marchf4.S
uniprot id: A0A1L8ENP8
uniprot id: A0A8J0U095
names: Subcellular Location Annotation
messages: Membrane

8355:ccn4.L
gene id: 8355:ccn4.L
uniprot id: A0A8J0VKK1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:sec16b.L
gene id: 8355:sec16b.L
uniprot id: A0A1L8GMK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

8355:ankrd13b.S
gene id: 8355:ankrd13b.S
uniprot id: A0A1L8H4W0
uniprot id: A0A8J0UJ67
uniprot id: A0A8J1MC28
uniprot id: A0A8J1MD35
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

8355:gpr180.S
gene id: 8355:gpr180.S
uniprot id: Q5FWM8
names: Subcellular Location Annotation
messages: Membrane

8355:pfkfb4.L
gene id: 8355:pfkfb4.L
uniprot id: A0A1L8GNZ6
uniprot id: A0A8J0V366
uniprot id: A0A8J0V3L2
uniprot id: A0A8J1MY06
uniprot id: A0A8J1MZI6
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

8355:cops4.L
gene id: 8355:cops4.L
uniprot id: A0A8J0T6P6
uniprot id: A2RRW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

8355:insl5.L
gene id: 8355:insl5.L
uniprot id: A0A1L8GLT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

8355:LOC121395458
gene id: 8355:LOC121395458
uniprot id: A0A8J1L8L8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:rflnb.S
gene id: 8355:rflnb.S
uniprot id: A1L2S1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

8355:dpyd.L
gene id: 8355:dpyd.L
uniprot id: A0A1L8GMQ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

8355:ppl.L
gene id: 8355:ppl.L
uniprot id: A0A1L8EYV4
names: Subcellular Location Annotation
messages: cytoskeleton

8355:fgd4.S
gene id: 8355:fgd4.S
uniprot id: A0A1L8GQD4
uniprot id: A0A8J0UNI1
uniprot id: A0A8J0UU70
uniprot id: A0A8J0UVD5
uniprot id: A0A8J1MPT3
names: Subcellular Location Annotation
messages: cytoskeleton

8355:LOC121396934
gene id: 8355:LOC121396934
uniprot id: A0A8J1LG48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8355:itpk1.S
gene id: 8355:itpk1.S
uniprot id: A0A8J1LLZ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ITPK1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
messages: Monomer.

8355:rap1gds1.S
gene id: 8355:rap1gds1.S
uniprot id: A0A8J0U0S1
uniprot id: Q5PPZ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum
messages: Interacts with ralB. Probably interacts with the post-translationally isoprenylated (geranyl-geranylation) forms of ral proteins. Interacts with both GDP-bound and GTP-bound forms of ralA, but interaction is much stronger with ralA-GDP (By similarity).
messages: Mitochondrion
messages: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.
messages: cytosol

8355:runx3.S
gene id: 8355:runx3.S
uniprot id: A0A1L8H7Y4
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108696670
gene id: 8355:LOC108696670
uniprot id: A0A1L8FMZ7
uniprot id: A0A8J0T344
uniprot id: A0A8J0T9I3
uniprot id: A0A8J1L7C0
uniprot id: A0A8J1L8Z0
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.

8355:spast.S
gene id: 8355:spast.S
uniprot id: A0A8J0VDD0
uniprot id: Q6AZT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules.
messages: Membrane
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region

8355:LOC108717861
gene id: 8355:LOC108717861
uniprot id: A0A1L8G283
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

8355:LOC108703426
gene id: 8355:LOC108703426
uniprot id: A0A8J0U232
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121393302
gene id: 8355:LOC121393302
uniprot id: A0A8J1KW79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:arl4c.L
gene id: 8355:arl4c.L
uniprot id: A0A1L8EWP2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8355:pcmtd2.L
gene id: 8355:pcmtd2.L
uniprot id: Q7ZXM7
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

8355:tollip.L
gene id: 8355:tollip.L
uniprot id: A0A8J1MUR6
uniprot id: Q6INE3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tollip family.
messages: Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.
messages: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance.
messages: Cytoplasm
messages: Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain). of cytotoxic polyQ proteins aggregates.

8355:gpr155.L
gene id: 8355:gpr155.L
uniprot id: A0A1L8EWG6
uniprot id: A0A8J0TUN9
uniprot id: A0A8J0TV57
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121397991
gene id: 8355:LOC121397991
uniprot id: A0A8J1LU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:mdfic.S
gene id: 8355:mdfic.S
uniprot id: A0A8J1MNU8
uniprot id: A0A8J1MPV0
uniprot id: A0A8J1MPV4
uniprot id: Q98SK0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MDFI family.
messages: Cytoplasm
messages: Expressed both maternally and zygotically, with expression persisting to at least tadpole stages.
messages: Expressed broadly at a low level in the early embryo.
messages: May act as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins. Retains nuclear Zic proteins in the cytoplasm (By similarity). Required for dorsoanterior development. Necessary for siamois to activate downstream target genes, including gsc, during execution of the dorsal organizer program. Also regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA.
messages: Nucleus
messages: The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation. The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm (By similarity).
messages: nucleolus

8355:fam189a1.S
gene id: 8355:fam189a1.S
uniprot id: A0A1L8GT28
uniprot id: A0A8J0UVQ7
uniprot id: A0A8J1MR74
names: Similarity
messages: Belongs to the ENTREP family.

8355:LOC108720028
gene id: 8355:LOC108720028
uniprot id: A0A1L8FS21
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

8355:igfbp1.S
gene id: 8355:igfbp1.S
uniprot id: Q6PAX6
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC108705887
gene id: 8355:LOC108705887
uniprot id: A0A8J1MJ70
names: Similarity
messages: Belongs to the WD repeat WDR91 family.

8355:ackr3.L
gene id: 8355:ackr3.L
uniprot id: Q8QFR6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:ltc4s.1.S
gene id: 8355:ltc4s.1.S
uniprot id: A0A1L8GR19
uniprot id: A0A8J1MSE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108701821
gene id: 8355:LOC108701821
uniprot id: A0A8J0TZJ2
names: Similarity
messages: Belongs to the FAM20 family.

8355:arpc1a.L
gene id: 8355:arpc1a.L
uniprot id: A0A1L8EXB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ARPC1 family.
messages: Component of the Arp2/3 complex.
messages: Nucleus
messages: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity).
messages: cytoskeleton

8355:tff3.8.L
gene id: 8355:tff3.8.L
uniprot id: Q9PT64
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:wscd1.S
gene id: 8355:wscd1.S
uniprot id: A0A1L8H658
uniprot id: A0A8J1MD32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

8355:nell1.S
gene id: 8355:nell1.S
uniprot id: A0A1L8GE42
uniprot id: A0A8J0QH24
uniprot id: A0A8J0VAC3
uniprot id: A0A8J1MZL2
uniprot id: A0A8J1N192
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ikbke.L
gene id: 8355:ikbke.L
uniprot id: A0A1L8HES5
uniprot id: Q32NR7
names: Subcellular Location Annotation
messages: Cytoplasm

8355:asf1b.L
gene id: 8355:asf1b.L
uniprot id: Q7T0M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4.
messages: Nucleus

8355:cep290.L
gene id: 8355:cep290.L
uniprot id: Q6INP6
names: Subcellular Location Annotation
messages: cilium basal body

8355:LOC108705051
gene id: 8355:LOC108705051
uniprot id: A0A310TQT5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:kcnma1.L
gene id: 8355:kcnma1.L
uniprot id: A0A8J0U313
uniprot id: A0A8J0U4A6
uniprot id: A0A8J0U6A6
uniprot id: A0A8J1L3Z2
uniprot id: A0A8J1L3Z7
uniprot id: A0A8J1L3Z9
uniprot id: A0A8J1L403
uniprot id: A0A8J1L409
uniprot id: A0A8J1L415
uniprot id: A0A8J1L420
uniprot id: A0A8J1L5N3
uniprot id: A0A8J1L5N9
uniprot id: A0A8J1L5P6
uniprot id: A0A8J1L6P5
uniprot id: A0A8J1L6Q1
uniprot id: A0A8J1L6Q6
uniprot id: Q90ZC7
names: Activity Regulation
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation (By similarity).
messages: Expressed during embryogenesis before differentiation of excitable tissues.
messages: Expressed in both the somites and neural tube of 1 day embryos. Within the nervous system, it is restricted to dorsal parts, and expressed centrally in regions dedicated to processing of sensory information. Six hours later, it is expressed segmentally within the somites. At this time, it is expressed in a primary sensory organ, the trigeminal ganglion. By 2 days, it is also expressed in other primary sensory organs, such as the otic vesicle, and the eye. Within the retina, it is expressed to an internal layer. In the developing otic vesicle, it is abundantly expressed near the apical surface. Isoform 3 is neural-specific, and is only expressed during late stages of neuronal differentiation.
messages: Homotetramer; which constitutes the calcium-activated potassium channel.
messages: It is uncertain whether Met-1 is the initiator or if the sequence starts further upstream.
messages: Membrane
messages: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity).
messages: The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel. It includes binding sites for Ca(2+) and Mg(2+) (By similarity).
messages: The S0 segment is essential for the modulation by the accessory beta subunits.
messages: The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor.
messages: The calcium bowl constitutes one of the Ca(2+) sensors and probably acts as a Ca(2+)-binding site. There are however other Ca(2+) sensors regions required for activation of the channel (By similarity).
messages: The heme-binding motif mediates inhibition of channel activation by heme. Carbon monoxide-bound heme leads to increased channel activation (By similarity).
messages: The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity).
messages: The protein was initially thought to contain two functionally distinct parts: The core channel (from the N-terminus to the S9 segment) that mediates the channel activity, and the cytoplasmic tail (from the S9 segment to the C-terminus) that mediates the calcium sensing. The situation is however more complex, since the core channel contains binding sites for Ca(2+) and Mg(2+).

8355:vasp.L
gene id: 8355:vasp.L
uniprot id: A0A8J0TEN9
uniprot id: Q6GQB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

8355:LOC121395553
gene id: 8355:LOC121395553
uniprot id: A0A1L8FLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

8355:LOC108699002
gene id: 8355:LOC108699002
uniprot id: A0A8J0TCQ1
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8355:LOC121393739
gene id: 8355:LOC121393739
uniprot id: A0A8J1KNY0
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

8355:eef1akmt1.S
gene id: 8355:eef1akmt1.S
uniprot id: Q6GN98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

8355:tgm1.L
gene id: 8355:tgm1.L
uniprot id: A0A8J1KTV0
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8355:cyp27b1.L
gene id: 8355:cyp27b1.L
uniprot id: A0A1L8HI76
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:eef1a1.S
gene id: 8355:eef1a1.S
uniprot id: A0A1L8G3E8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8355:cln3.L
gene id: 8355:cln3.L
uniprot id: Q6DE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Lysosome membrane
messages: Membrane

8355:tiprl.S
gene id: 8355:tiprl.S
uniprot id: A0A1L8GEC0
uniprot id: A0A8J0V6J8
names: Similarity
messages: Belongs to the TIP41 family.

8355:cdh8.S
gene id: 8355:cdh8.S
uniprot id: A0A1L8GEM0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8355:cnfn.2.S
gene id: 8355:cnfn.2.S
uniprot id: Q3KPU1
names: Similarity
messages: Belongs to the cornifelin family.

8355:dipk1a.S
gene id: 8355:dipk1a.S
uniprot id: A0A1L8GG90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

8355:MGC115510
gene id: 8355:MGC115510
uniprot id: A0A1L8GGW3
uniprot id: A0A8J0V423
uniprot id: A0A8J0V4U1
uniprot id: Q4KLS2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

8355:ckap5.L
gene id: 8355:ckap5.L
uniprot id: A0A1L8GIT7
uniprot id: A0A8J0UYM9
uniprot id: A0A8J1MU74
uniprot id: A0A8J1MVB5
uniprot id: A0A8J1MWL3
uniprot id: Q9PT63
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TOG/XMAP215 family.
messages: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12176362, PubMed:18191222, PubMed:21282620). Plays a major role in organizing spindle poles (PubMed:23974040). In spindle formation protects kinetochore microtubules from depolymerization by kif2c and has an essential role in centrosomal microtubule assembly independently of kif2c activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (By similarity).
messages: Interacts with tacc3; two molecules of ckap5 interact with 1 molecule of tacc3 probably mediated by coiled coil domains forming a four-helix bundle. Interacts with tacc3 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges. Interacts with ndc80; indicative for an association with the NDC80 comnplex (By similarity).
messages: The TOG (tumor overexpressed gene) domains are arranged in a N-terminal pentameric array with each domain composed of six (for the most part non-canonical) HEAT repeats forming a oblong paddle-like structure. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains in the array seem to be structurally and functionally polarized. Differential functions may range from microtubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice. TOG 1 and TOG 2 are critical for microtubule polymerase activity.
messages: centrosome
messages: cytoskeleton
messages: kinetochore
messages: spindle
messages: spindle pole

8355:LOC121393705
gene id: 8355:LOC121393705
uniprot id: A0A8J1KQ94
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ndnf.S
gene id: 8355:ndnf.S
uniprot id: A0A1L8HM31
names: Subcellular Location Annotation
messages: Secreted

8355:fam214b.L
gene id: 8355:fam214b.L
uniprot id: A0A1L8I3B7
names: Similarity
messages: Belongs to the FAM214 family.

8355:LOC108718155
gene id: 8355:LOC108718155
uniprot id: A0A8J0VGB9
uniprot id: A0A8J1KUA5
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

8355:cd99l2.L
gene id: 8355:cd99l2.L
uniprot id: A0A1L8F7P3
uniprot id: A0A8J0TIM2
uniprot id: A0A8J0TJE8
uniprot id: A0A8J0TKB2
names: Similarity
messages: Belongs to the CD99 family.

8355:slc10a4.L
gene id: 8355:slc10a4.L
uniprot id: A0A1L8HTQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

8355:nsa2.S
gene id: 8355:nsa2.S
uniprot id: A0A8J1M413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

8355:LOC108699400
gene id: 8355:LOC108699400
uniprot id: A0A8J0TK51
names: Similarity
messages: Belongs to the MHC class I family.

8355:XB5863395.L
gene id: 8355:XB5863395.L
uniprot id: Q6GLX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RGS7BP/RGS9BP family.
messages: Membrane
messages: Regulator of G protein-coupled receptor (GPCR) signaling. Probably acts by regulating the activity of some 'R7' family protein (RGS6, RGS7, RGS9 and/or RGS11).

8355:rab39b.S
gene id: 8355:rab39b.S
uniprot id: A0A1L8F2P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

8355:gpc1.S
gene id: 8355:gpc1.S
uniprot id: A0A1L8G4N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: extracellular space

8355:LOC121401560
gene id: 8355:LOC121401560
uniprot id: A0A8J1MLX6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:lsm3.L
gene id: 8355:lsm3.L
uniprot id: A0A1L8GPJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

8355:LOC121394480
gene id: 8355:LOC121394480
uniprot id: A0A8J1KW87
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:hpd-like.2.L
gene id: 8355:hpd-like.2.L
uniprot id: Q6PA53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

8355:dppa2.L
gene id: 8355:dppa2.L
uniprot id: A0A8J0U315
uniprot id: A0A8J0U3V4
uniprot id: A0A8J0U5U9
uniprot id: Q4V7G6
names: Subcellular Location Annotation
messages: Nucleus

8355:glo1.S
gene id: 8355:glo1.S
uniprot id: A0A1L8G0V3
uniprot id: Q68ES2
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

8355:LOC108711045
gene id: 8355:LOC108711045
uniprot id: A0A1L8GYA7
uniprot id: A0A8J1MKD3
uniprot id: A0A8J1MKE8
uniprot id: A0A8J1ML69
uniprot id: A0A8J1MLC8
uniprot id: A0A8J1MME1
uniprot id: A0A8J1MME6
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

8355:acadsb.L
gene id: 8355:acadsb.L
uniprot id: A0A1L8FJ05
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8355:LOC108704296
gene id: 8355:LOC108704296
uniprot id: A0A1L8G0S1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:rfc1.L
gene id: 8355:rfc1.L
uniprot id: A0A1L8HTJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

8355:mettl11b.L
gene id: 8355:mettl11b.L
uniprot id: A0A1L8GNJ9
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

8355:naa10.S
gene id: 8355:naa10.S
uniprot id: A0A8J0TP87
uniprot id: Q7ZXW3
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

8355:b3galt5.2.S
gene id: 8355:b3galt5.2.S
uniprot id: A0A1L8H5E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108706129
gene id: 8355:LOC108706129
uniprot id: A0A8J1M6E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108700820
gene id: 8355:LOC108700820
uniprot id: A0A1L8ES72
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

8355:tapt1.L
gene id: 8355:tapt1.L
uniprot id: A0A1L8HTF0
uniprot id: A0A8J0THC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

8355:LOC108703447
gene id: 8355:LOC108703447
uniprot id: A0A8J0U324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108702331
gene id: 8355:LOC108702331
uniprot id: A0A8J0TR24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:psmb7.2.L
gene id: 8355:psmb7.2.L
uniprot id: Q7T0U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:mctp2.L
gene id: 8355:mctp2.L
uniprot id: A0A1L8H0Z4
names: Subcellular Location Annotation
messages: Membrane

8355:foxf2.L
gene id: 8355:foxf2.L
uniprot id: A0A1L8FXQ3
names: Subcellular Location Annotation
messages: Nucleus

8355:atr.L
gene id: 8355:atr.L
uniprot id: A0A8J0V7Z5
uniprot id: A0A8J0V998
uniprot id: A0A8J1KL41
uniprot id: Q9DE14
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Chromosome
messages: Forms a heterodimer with atrip. Interacts with topbp1 in the presence of atrip.
messages: Kinase activity is activated by topbp1.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism.

8355:gucy2d.S
gene id: 8355:gucy2d.S
uniprot id: A0A8J0U2E3
uniprot id: A0A8J1MSS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

8355:LOC108713086
gene id: 8355:LOC108713086
uniprot id: A0A1L8HWZ5
uniprot id: A0A8J1KLG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8355:pdik1l.L
gene id: 8355:pdik1l.L
uniprot id: A0A8J0UEI5
uniprot id: Q6NU98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Nucleus

8355:rplp2.L
gene id: 8355:rplp2.L
uniprot id: Q0IHG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

8355:LOC108714147
gene id: 8355:LOC108714147
uniprot id: A0A1L8GLE8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:intu.S
gene id: 8355:intu.S
uniprot id: A0A1L8HLW4
uniprot id: A0A8J1LS33
uniprot id: Q2I0E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the inturned family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasm
messages: Expressed in the neural plate during neural tube closure with subsequent strong expression in the ventral neural tube and in facial mesenchyme.
messages: Interacts with fuz and wdpcp; fuz, intu and wdpcp probably form the core CPLANE (ciliogenesis and planar polarity effectors) complex.
messages: Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Required for ciliogenesis by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Proposed to function as core component of a functional module called CPLANE (ciliogenesis and planar polarity effectors) involved in recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Controls the localization of both rhoa and disheveled in multi-ciliated cells. Has an indirect effect on hedgehog signaling.
messages: cilium basal body

8355:vps37b.S
gene id: 8355:vps37b.S
uniprot id: A0A8J0TTM7
uniprot id: Q6PAA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

8355:gdf5.S
gene id: 8355:gdf5.S
uniprot id: A0A1L8EKU9
names: Similarity
messages: Belongs to the TGF-beta family.

8355:dlk1.S
gene id: 8355:dlk1.S
uniprot id: A0A8J1LN63
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tcp1.L
gene id: 8355:tcp1.L
uniprot id: Q7ZXN9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

8355:ppp2ca.S
gene id: 8355:ppp2ca.S
uniprot id: A0A1L8GR14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

8355:LOC121399291
gene id: 8355:LOC121399291
uniprot id: A0A8J1M1A6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:st8sia3.L
gene id: 8355:st8sia3.L
uniprot id: A0A1L8I2N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:plppr3.S
gene id: 8355:plppr3.S
uniprot id: A0A1L8HNC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:podxl2.S
gene id: 8355:podxl2.S
uniprot id: A0A1L8GHP0
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108704801
gene id: 8355:LOC108704801
uniprot id: A0A8J1LHW6
uniprot id: A0A8J1LHZ4
uniprot id: A0A8J1LJ94
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

8355:sh3bp5l.S
gene id: 8355:sh3bp5l.S
uniprot id: A0A1L8F3H4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

8355:lyrm7.L
gene id: 8355:lyrm7.L
uniprot id: A0A1L8I1B6
uniprot id: A0A8J0UA49
uniprot id: A0A8J0UGT7
uniprot id: Q63ZL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

8355:ano10.L
gene id: 8355:ano10.L
uniprot id: A0A1L8FWG6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108699478
gene id: 8355:LOC108699478
uniprot id: A0A1L8FDH9
uniprot id: A0A8J1LKI7
names: Subcellular Location Annotation
messages: cytoskeleton

8355:thbs1.S
gene id: 8355:thbs1.S
uniprot id: A0A8J1LMA6
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:clcnkb.L
gene id: 8355:clcnkb.L
uniprot id: Q9W701
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Cell membrane
messages: Expressed in two distinct regions of the kidney; the proximal convoluted tubule and the diluting segment.
messages: N-glycosylated on a single asparagine, probably Asn-365 or Asn-375.
messages: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, the stabilization of membrane potential, signal transduction and transepithelial transport.

8355:cltb.S
gene id: 8355:cltb.S
uniprot id: A0A8J1MQ88
uniprot id: Q6DE32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

8355:LOC108718324
gene id: 8355:LOC108718324
uniprot id: A0A1L8G5V4
uniprot id: A0A8J0VDW7
uniprot id: A0A8J0VGU5
uniprot id: A0A8J1KWE3
uniprot id: A0A8J1KXV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

8355:orc2.S
gene id: 8355:orc2.S
uniprot id: A0A8J0TXD6
uniprot id: A0A8J0U0B5
uniprot id: Q5XGS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

8355:LOC108708439
gene id: 8355:LOC108708439
uniprot id: A0A1L8HH44
uniprot id: A0A8J1M9D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

8355:LOC108714516
gene id: 8355:LOC108714516
uniprot id: A0A8J0V259
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108697300
gene id: 8355:LOC108697300
uniprot id: A0A1L8FDM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ccn4.S
gene id: 8355:ccn4.S
uniprot id: A0A1L8FU26
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:p2rx7.L
gene id: 8355:p2rx7.L
uniprot id: A0A8J1LFI8
uniprot id: Q8UUP5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8355:LOC108696960
gene id: 8355:LOC108696960
uniprot id: A0A8J0T464
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:LOC121393215
gene id: 8355:LOC121393215
uniprot id: A0A8J1KI86
uniprot id: A0A8J1KK01
uniprot id: A0A8J1KLD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8355:golt1b.S
gene id: 8355:golt1b.S
uniprot id: A0A8J0UV00
uniprot id: Q3KPT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

8355:or52l1l.L
gene id: 8355:or52l1l.L
uniprot id: A0A8J0UCV7
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108696205
gene id: 8355:LOC108696205
uniprot id: A0A1L8FJQ1
names: Similarity
messages: Belongs to the hexokinase family.

8355:gpcpd1.L
gene id: 8355:gpcpd1.L
uniprot id: Q32NP5
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8355:gphn.S
gene id: 8355:gphn.S
uniprot id: A0A8J1LKM0
uniprot id: A0A8J1LKM5
uniprot id: A0A8J1LKN0
uniprot id: A0A8J1LKN6
uniprot id: A0A8J1LKP2
uniprot id: A0A8J1LKS7
uniprot id: A0A8J1LKT1
uniprot id: A0A8J1LKT6
uniprot id: A0A8J1LKU1
uniprot id: A0A8J1LKU6
uniprot id: A0A8J1LLK9
uniprot id: A0A8J1LLL5
uniprot id: A0A8J1LLM0
uniprot id: A0A8J1LLM6
uniprot id: A0A8J1LLW1
uniprot id: A0A8J1LLW6
uniprot id: A0A8J1LLX0
uniprot id: A0A8J1LLX5
uniprot id: A0A8J1LN33
uniprot id: A0A8J1LN38
uniprot id: A0A8J1LN51
uniprot id: A0A8J1LN56
uniprot id: Q6GQZ6
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

8355:rps24.L
gene id: 8355:rps24.L
uniprot id: A0A8J1L411
uniprot id: A0A8J1L418
uniprot id: A0A8J1L5T4
uniprot id: A0A8J1L5U7
uniprot id: P02377
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

8355:psmb5.S
gene id: 8355:psmb5.S
uniprot id: A0A1L8HPN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:esrrg.L
gene id: 8355:esrrg.L
uniprot id: A0A1L8G6Q9
uniprot id: A0A8J0V6B4
uniprot id: A0A8J0V9F9
uniprot id: A0A8J0VAR5
uniprot id: A0A8J1KMB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8355:LOC108695711
gene id: 8355:LOC108695711
uniprot id: A0A8J1LBQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8355:gmppa.L
gene id: 8355:gmppa.L
uniprot id: A0A1L8EVM9
uniprot id: Q66KG5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

8355:otp.L
gene id: 8355:otp.L
uniprot id: A0A1L8I213
names: Subcellular Location Annotation
messages: Nucleus

8355:zeb2.S
gene id: 8355:zeb2.S
uniprot id: A0A1L8ENX7
uniprot id: A0A8J1LWU9
uniprot id: A0A8J1LXQ1
uniprot id: Q5U4S2
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

8355:arsd.L
gene id: 8355:arsd.L
uniprot id: A0A1L8HDI9
uniprot id: Q6GMA1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8355:nkiras1.S
gene id: 8355:nkiras1.S
uniprot id: A0A1L8FRE4
uniprot id: A0A1L8FRI5
uniprot id: A0JMW9
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

8355:epb41l5.S
gene id: 8355:epb41l5.S
uniprot id: A0A1L8ENN6
uniprot id: A0A8J0TST5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.

8355:mid2.L
gene id: 8355:mid2.L
uniprot id: A0A1L8F6M8
uniprot id: A0A8J1LEF2
uniprot id: D8WX03
names: Subcellular Location Annotation
messages: cytoskeleton

8355:sbno1.L
gene id: 8355:sbno1.L
uniprot id: A0A8J1L1I3
uniprot id: A0A8J1L1K0
uniprot id: A0A8J1L348
names: Similarity
messages: Belongs to the SBNO family.

8355:kif22.L
gene id: 8355:kif22.L
uniprot id: A0A8J0TVA8
uniprot id: Q7ZYL5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA.
messages: Nucleus
messages: Ubiquitinated, leading to its subsequent proteasomal degradation.
messages: cytoskeleton

8355:smc1a.S
gene id: 8355:smc1a.S
uniprot id: A0A1L8F1L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

8355:LOC108703923
gene id: 8355:LOC108703923
uniprot id: A0A8J1LV28
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:ap1s1.S
gene id: 8355:ap1s1.S
uniprot id: A0A8J0U2C8
uniprot id: A0A8J0U582
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

8355:cyp19a1.L
gene id: 8355:cyp19a1.L
uniprot id: Q68FK0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:abitram.S
gene id: 8355:abitram.S
uniprot id: A0A1L8FS20
uniprot id: Q6GR35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: May regulate actin polymerization, filopodia dynamics and arborization of neurons.
messages: Nucleus
messages: Nucleus speckle
messages: dendrite
messages: growth cone
messages: lamellipodium

8355:LOC108697330
gene id: 8355:LOC108697330
uniprot id: A0A1L8FDU1
names: Similarity
messages: Belongs to the RimK family.

8355:usp2.S
gene id: 8355:usp2.S
uniprot id: A0A1L8FFZ3
uniprot id: A0A8J0TCJ3
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:xenoxin1.L
gene id: 8355:xenoxin1.L
uniprot id: Q09022
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed by the skin dorsal glands.
messages: Lacks alpha-neurotoxic activity, has apparently no antibacterial activity, nor anti-coagulant potency.
messages: Secreted

8355:LOC108718317
gene id: 8355:LOC108718317
uniprot id: A0A8J1KUT5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:eef1aknmt.S
gene id: 8355:eef1aknmt.S
uniprot id: Q6NTR1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (eef1a1 and eef1a2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates the N-terminus of eef1a1 and eef1a2. Via its N-terminus dimethylates lysine residues of eef1a1 and eef1a2.

8355:mfap2.L
gene id: 8355:mfap2.L
uniprot id: Q8AVW2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:set.S
gene id: 8355:set.S
uniprot id: A0A8J0TL34
uniprot id: A0A8J1LN00
uniprot id: Q9PVV6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

8355:LOC108702565
gene id: 8355:LOC108702565
uniprot id: A0A1L8EL61
uniprot id: A0A8J0U080
uniprot id: A0A8J1LZP3
names: Subcellular Location Annotation
messages: Membrane

8355:amotl1.L
gene id: 8355:amotl1.L
uniprot id: A0A8J0UBH1
uniprot id: A0A8J1M5X7
uniprot id: B1WBC7
names: Similarity
messages: Belongs to the angiomotin family.

8355:plpp2.S
gene id: 8355:plpp2.S
uniprot id: A0A8J0U5H7
uniprot id: Q6GR33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:LOC108718452
gene id: 8355:LOC108718452
uniprot id: A0A1L8FUP0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8355:cdc45.S
gene id: 8355:cdc45.S
uniprot id: A0A8J0U120
uniprot id: Q6AZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

8355:hdac4.S
gene id: 8355:hdac4.S
uniprot id: A0A1L8EPF2
uniprot id: A0A8J0U0S7
uniprot id: A0A8J1LZ13
uniprot id: A0A8J1M087
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

8355:zic5.S
gene id: 8355:zic5.S
uniprot id: B7ZPU8
uniprot id: Q9IB89
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At blastula and early gastrula stage (stages 9-10.25), expressed weakly throughout the ectoderm. At the late gastrula stage (stages 11.5-13), expression is restricted to the prospective neural fold region and anterior neural plate border region. Expression becomes enhanced in the prospective midbrain and hindbrain region at the late gastrula stage. Expression in the neural plate border region continues in the neurula stage with expression in the anterior region more enhanced. Expression represents the neural plate edges and part of the neural fold. In the tailbud stages expression is restricted to the eyes, dorsal brain and the posterior part of the dorsal spinal cord. In the brain, expression is higher in the mesencephalon and rhombencephalon.
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: By FGF-signaling. By snai1/snail. By zic1, zic2, zic3 and zic5.
messages: Expressed both maternally and zygotically. Expression increases from stage 11 (late gastrula), when the neural crest is induced, through to the neurula and tailbud stages.
messages: May bind to DNA (By similarity). Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Does not induce anterior neural tissue.
messages: Nucleus

8355:LOC108710980
gene id: 8355:LOC108710980
uniprot id: A0A1L8GY09
uniprot id: A0A8J0UQI7
uniprot id: A0A8J1ML08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

8355:slco2a1.S
gene id: 8355:slco2a1.S
uniprot id: A0A1L8G508
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

8355:LOC108706280
gene id: 8355:LOC108706280
uniprot id: A0A8J1MAC7
names: Subcellular Location Annotation
messages: Membrane

8355:saxo2.L
gene id: 8355:saxo2.L
uniprot id: A0A8J0UMF0
uniprot id: Q6DCB9
names: Similarity
messages: Belongs to the FAM154 family.

8355:LOC108705053
gene id: 8355:LOC108705053
uniprot id: A0A8J1LDH3
names: Similarity
messages: Belongs to the BTG family.

8355:fam8a1.L
gene id: 8355:fam8a1.L
uniprot id: A0A1L8FY49
names: Subcellular Location Annotation
messages: Membrane

8355:fam167b.L
gene id: 8355:fam167b.L
uniprot id: A0A1L8HFH9
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

8355:elk3.S
gene id: 8355:elk3.S
uniprot id: A0A1L8GUU6
uniprot id: A0A8J0UWU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:fshr.S
gene id: 8355:fshr.S
uniprot id: A0A1L8G1D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

8355:spop.S
gene id: 8355:spop.S
uniprot id: Q0IHH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tdpoz family.
messages: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
messages: Homodimer. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and SPOP, plus a target protein (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The BTB (POZ) domain mediates dimerization and interaction with CUL3.
messages: The MATH domain mediates interaction with protein-ubiquitin ligase substrates.

8355:sephs3.L
gene id: 8355:sephs3.L
uniprot id: A0A8J0Q934
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

8355:hhipl1.S
gene id: 8355:hhipl1.S
uniprot id: A0A1L8F099
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mrps14.S
gene id: 8355:mrps14.S
uniprot id: A0A1L8GG11
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

8355:slc7a9.S
gene id: 8355:slc7a9.S
uniprot id: A0A8J1KIJ4
uniprot id: A0A8J1KK97
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121398218
gene id: 8355:LOC121398218
uniprot id: A0A8J1LWB7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

8355:ndufaf4.L
gene id: 8355:ndufaf4.L
uniprot id: Q3KQ61
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

8355:mrpl44.S
gene id: 8355:mrpl44.S
uniprot id: Q7SZ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

8355:eaf1.L
gene id: 8355:eaf1.L
uniprot id: A0A8J0VHK1
uniprot id: Q6GND1
names: Similarity
messages: Belongs to the EAF family.

8355:slc25a47.L
gene id: 8355:slc25a47.L
uniprot id: A0A8J0TIE2
uniprot id: A0A8J1LHJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:LOC108699340
gene id: 8355:LOC108699340
uniprot id: A0A1L8FC01
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

8355:pnoc.L
gene id: 8355:pnoc.L
uniprot id: A0A1L8GBZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

8355:tmem255b.S
gene id: 8355:tmem255b.S
uniprot id: A0A1L8H8S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

8355:tspo.L
gene id: 8355:tspo.L
uniprot id: Q8AVD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

8355:XB996286.L
gene id: 8355:XB996286.L
uniprot id: A0A310TMN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:LOC121395518
gene id: 8355:LOC121395518
uniprot id: A0A8J1L676
names: Function
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

8355:bmi1.L
gene id: 8355:bmi1.L
uniprot id: Q640D5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a PRC1-like complex. Interacts with cbx4 (By similarity).
messages: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2 (By similarity).
messages: Nucleus

8355:acvr2a.L
gene id: 8355:acvr2a.L
uniprot id: A0A8J1LPI6
uniprot id: A0A8J1LPL7
uniprot id: A0A8J1LQG1
uniprot id: A0A8J1LRX8
uniprot id: P27039
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: Receptor for activin A, activin B and inhibin A. Involved in transmembrane signaling.

8355:dus3l.L
gene id: 8355:dus3l.L
uniprot id: Q7ZWS1
names: Function
names: Similarity
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.

8355:fubp1.L
gene id: 8355:fubp1.L
uniprot id: A0A8J0Q691
uniprot id: A0A8J0V3K9
uniprot id: Q6IRB9
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108719687
gene id: 8355:LOC108719687
uniprot id: A0A8J1L1N9
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8355:LOC108719033
gene id: 8355:LOC108719033
uniprot id: A0A1L8FX25
names: Similarity
messages: Belongs to the UPF0711 family.

8355:gli2.L
gene id: 8355:gli2.L
uniprot id: A0A1L8EV94
uniprot id: A0A8J0TJ03
uniprot id: Q91661
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Has an essential role in the early embryonic patterning of mesoderm and neuroectoderm.
messages: Nucleus

8355:vgll4l.L
gene id: 8355:vgll4l.L
uniprot id: A0A1L8F5L3
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

8355:LOC100158309
gene id: 8355:LOC100158309
uniprot id: A0A8J0VPY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8355:pea15.S
gene id: 8355:pea15.S
uniprot id: A0A1L8F4Q4
names: Subcellular Location Annotation
messages: Cytoplasm

8355:vamp2.L
gene id: 8355:vamp2.L
uniprot id: P47193
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cell membrane
messages: Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity).
messages: synaptic vesicle membrane

8355:idi1.S
gene id: 8355:idi1.S
uniprot id: A0A1L8FQL2
uniprot id: A0A8J0VLS2
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

8355:mindy2.S
gene id: 8355:mindy2.S
uniprot id: A0A1L8GT27
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

8355:pkd1.L
gene id: 8355:pkd1.L
uniprot id: A0A1L8EYH9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC121396288
gene id: 8355:LOC121396288
uniprot id: A0A8J1L9Z8
uniprot id: A0A8J1LEG7
uniprot id: Q5HZL2
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

8355:LOC108702739
gene id: 8355:LOC108702739
uniprot id: A0A8J1LWX5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108710442
gene id: 8355:LOC108710442
uniprot id: A0A8J0UPB4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:sf3b1.S
gene id: 8355:sf3b1.S
uniprot id: O57683
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B1 family.
messages: Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A and DDX42. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP).
messages: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
messages: Nucleus

8355:LOC108695644
gene id: 8355:LOC108695644
uniprot id: A0A1L8HZK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121393724
gene id: 8355:LOC121393724
uniprot id: A0A8J1KNW0
uniprot id: A0A8J1KNW5
uniprot id: A0A8J1KQJ4
uniprot id: A0A8J1KRZ6
names: Caution
names: Similarity
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:a4gnt.L
gene id: 8355:a4gnt.L
uniprot id: Q4KLB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:hspa8.L
gene id: 8355:hspa8.L
uniprot id: A0A8J1L5Q7
uniprot id: Q7ZTK6
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8355:LOC108696557
gene id: 8355:LOC108696557
uniprot id: A0A1L8FM60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

8355:LOC108714306
gene id: 8355:LOC108714306
uniprot id: A0A8J0V2I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

8355:LOC108699023
gene id: 8355:LOC108699023
uniprot id: A0A8J0TCR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:MGC82469
gene id: 8355:MGC82469
uniprot id: A0A8J1M784
uniprot id: Q6INI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
messages: Cytoplasm
messages: Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
messages: Homodimer.

8355:fdx2.L
gene id: 8355:fdx2.L
uniprot id: Q5FWQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adrenodoxin/putidaredoxin family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Component of the mitochondrial core iron-sulfur cluster (ISC) complex composed of NFS1, LYRM4, NDUFAB1, ISCU, FXN, and FDX2; this complex is an heterohexamer containing two copies of each monomer.
messages: Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity).
messages: Mitochondrion
messages: Mitochondrion matrix

8355:cux2.L
gene id: 8355:cux2.L
uniprot id: A0A1L8I145
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8355:polr2g.L
gene id: 8355:polr2g.L
uniprot id: A2BD76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

8355:prkar1a.S
gene id: 8355:prkar1a.S
uniprot id: Q6DJJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

8355:anxa6.L
gene id: 8355:anxa6.L
uniprot id: Q6GNT0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

8355:rab19.L
gene id: 8355:rab19.L
uniprot id: Q32NQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane

8355:tigar.S
gene id: 8355:tigar.S
uniprot id: Q4V7R0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family.
messages: Cytoplasm
messages: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May play a role in mitophagy inhibition.
messages: Mitochondrion
messages: Not expected to have any kinase activity.
messages: Nucleus

8355:pgpep1l.S
gene id: 8355:pgpep1l.S
uniprot id: A0A1L8GSI5
names: Similarity
messages: Belongs to the peptidase C15 family.

8355:pspn.L
gene id: 8355:pspn.L
uniprot id: A0A8J0UN09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

8355:pck2.L
gene id: 8355:pck2.L
uniprot id: Q6INJ3
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

8355:aacs.L
gene id: 8355:aacs.L
uniprot id: A0A1L8I0U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

8355:LOC121396193
gene id: 8355:LOC121396193
uniprot id: A0A8J1LDQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

8355:ccz1b.S
gene id: 8355:ccz1b.S
uniprot id: Q7T102
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCZ1 family.
messages: Lysosome membrane

8355:frzb2.S
gene id: 8355:frzb2.S
uniprot id: A0A1L8GHR8
uniprot id: A0A1L8GHT3
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tmtops2.S
gene id: 8355:tmtops2.S
uniprot id: A0A1L8H8M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8355:notch1.L
gene id: 8355:notch1.L
uniprot id: A0A1L8F627
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:rps13.S
gene id: 8355:rps13.S
uniprot id: P49393
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

8355:kcnab3.L
gene id: 8355:kcnab3.L
uniprot id: A0A1L8H3C4
uniprot id: A0A8J1MPD2
uniprot id: Q9PTM4
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters functional properties of Kv1.1 and Kv1.2.
messages: Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm
messages: Expression first detected in brain and most anterior regions of spinal cord at embryonic stage 24 (26 hours). By stage 29 (35 hours) expression is also detected in posterior regions of spinal cord.
messages: Forms heteromultimeric complex with alpha subunits.

8355:LOC108701779
gene id: 8355:LOC108701779
uniprot id: A0A8J1LT60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108704164
gene id: 8355:LOC108704164
uniprot id: A0A8J0TW78
uniprot id: A0A8J1KS42
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

8355:LOC108704299
gene id: 8355:LOC108704299
uniprot id: A0A8J0U506
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:foxg1.L
gene id: 8355:foxg1.L
uniprot id: Q9YHC5
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A neural-specific transcription factor that can act as both a transcriptional activator and a transcriptional repressor. Both represses and activates neuronal differentiation in a dose-dependent manner, independently regulating cell fate choice and cell proliferation. Converts ectoderm to a neural fate. Suppresses the transcription of the cell cycle inhibitor p27xic1 and promotes the proliferation of neuroectodermal cells at a high concentration. Promotes the transcription of p27xic1 and inhibits ectodermal proliferation at low concentrations. The transcription factors foxd1 and foxg1 mutually repress each other to pattern the forebrain.
messages: At late gastrula and early neurula stages, expressed in a narrow stripe at the anterior end of the neural plate. At later stages, this stripe of expression thickens and expression also appears in the lateral margin of the neural plate. The anterior line differentiates to show expression in the forebrain, anterior (nasal) retina and olfactory placode, whereas the lateral cells form neural crest cells that migrate in the first branchial arch. In tailbud stages and tadpoles, expressed primarily in the neuroepithelial cells of the telencephalon.
messages: Nucleus

8355:erh.L
gene id: 8355:erh.L
uniprot id: A0A8J0TFA1
uniprot id: Q71U69
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

8355:LOC108717088
gene id: 8355:LOC108717088
uniprot id: A0A1L8GB51
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:slc16a14.L
gene id: 8355:slc16a14.L
uniprot id: A0A1L8GB49
names: Subcellular Location Annotation
messages: Membrane

8355:KEF37 p12
gene id: 8355:KEF37_p12
uniprot id: P03894
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

8355:ube2n.L
gene id: 8355:ube2n.L
uniprot id: A0A1L8GYC6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:crygdl.6.L
gene id: 8355:crygdl.6.L
uniprot id: A0A8J1MIH7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:serp1.S
gene id: 8355:serp1.S
uniprot id: Q66KT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

8355:sgo2.S
gene id: 8355:sgo2.S
uniprot id: A0A1L8EPV7
uniprot id: A0A8J1LZ78
uniprot id: A0A8J1M060
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

8355:zdhhc20.S
gene id: 8355:zdhhc20.S
uniprot id: A0A1L8HAP2
uniprot id: A0A8J0UH54
uniprot id: A0A8J0UIK5
uniprot id: Q6AZE8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:LOC121397292
gene id: 8355:LOC121397292
uniprot id: A0A8J1LM85
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC121398262
gene id: 8355:LOC121398262
uniprot id: A0A8J1LVZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

8355:tmem45b.S
gene id: 8355:tmem45b.S
uniprot id: A0A1L8FFR4
uniprot id: Q6NS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

8355:LOC108716616
gene id: 8355:LOC108716616
uniprot id: A0A8J0VA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:mrpl42.S
gene id: 8355:mrpl42.S
uniprot id: A0A1L8GUR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

8355:XB5951253.L
gene id: 8355:XB5951253.L
uniprot id: A0A1L8HDV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

8355:LOC108718513
gene id: 8355:LOC108718513
uniprot id: A0A8J1KXW5
uniprot id: A0A8J1KXX8
uniprot id: A0A8J1KZI5
uniprot id: A0A8J1L0U5
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:eya1.S
gene id: 8355:eya1.S
uniprot id: A0A1L8FT71
uniprot id: A0A8J0T4V6
uniprot id: A0A8J0T745
uniprot id: A0A8J0T757
uniprot id: A0A8J0T815
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

8355:gorasp2.S
gene id: 8355:gorasp2.S
uniprot id: A0A8J0U0Y5
uniprot id: Q4V819
names: Similarity
messages: Belongs to the GORASP family.

8355:st6galnac6.L
gene id: 8355:st6galnac6.L
uniprot id: A0A8J1LI59
uniprot id: A0A8J1LKI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:cmtm6.S
gene id: 8355:cmtm6.S
uniprot id: A0A1L8FRH1
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121401347
gene id: 8355:LOC121401347
uniprot id: A0A8J1MJ18
names: Subcellular Location Annotation
messages: Membrane

8355:dlk2.S
gene id: 8355:dlk2.S
uniprot id: A0A1L8G115
uniprot id: A0A8J0VJU2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:fras1.S
gene id: 8355:fras1.S
uniprot id: A0A8J1LXC3
names: Similarity
messages: Belongs to the FRAS1 family.

8355:coq8a.S
gene id: 8355:coq8a.S
uniprot id: A0A1L8G0Y4
uniprot id: A2RV68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

8355:bicd2l.L
gene id: 8355:bicd2l.L
uniprot id: Q5FWL8
names: Similarity
messages: Belongs to the BicD family.

8355:adamts4.L
gene id: 8355:adamts4.L
uniprot id: A0A1L8FD05
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:tub.L
gene id: 8355:tub.L
uniprot id: A0A1L8GIB3
uniprot id: A0A8J1MV28
uniprot id: A0A8J1MWB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

8355:LOC108712232
gene id: 8355:LOC108712232
uniprot id: A0A8J0UTG2
uniprot id: A0A8J1KIU4
uniprot id: A0A8J1KIW2
uniprot id: A0A8J1KIW7
uniprot id: A0A8J1KIW8
names: Subcellular Location Annotation
messages: ruffle membrane

8355:shmt1.L
gene id: 8355:shmt1.L
uniprot id: Q8AVC0
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

8355:med26.L
gene id: 8355:med26.L
uniprot id: Q90YY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 26 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8355:bcap31.L
gene id: 8355:bcap31.L
uniprot id: A0A8J0U7C6
uniprot id: Q6DFT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

8355:LOC108698436
gene id: 8355:LOC108698436
uniprot id: A0A1L8F7K0
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108716269
gene id: 8355:LOC108716269
uniprot id: A0A8J0V5X2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:map2k4.S
gene id: 8355:map2k4.S
uniprot id: A0A8J1LY57
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:mttp.2.S
gene id: 8355:mttp.2.S
uniprot id: A0A8J0TUE0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:eif5.L
gene id: 8355:eif5.L
uniprot id: A0A1L8FA49
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

8355:gja4.S
gene id: 8355:gja4.S
uniprot id: Q6GP02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:LOC121399769
gene id: 8355:LOC121399769
uniprot id: A0A8J1M899
names: Subcellular Location Annotation
messages: Membrane

8355:slc26a4.1.S
gene id: 8355:slc26a4.1.S
uniprot id: A0A8J0UV48
uniprot id: A0A8J1MTT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

8355:grik2.L
gene id: 8355:grik2.L
uniprot id: A0A1L8G8Y6
uniprot id: B9V8S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:slc25a32.L
gene id: 8355:slc25a32.L
uniprot id: Q5PQ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:LOC108696894
gene id: 8355:LOC108696894
uniprot id: A0A1L8HYB5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:tcf21.L
gene id: 8355:tcf21.L
uniprot id: Q6GNB7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: At the start of neurulation (stage 13), expressed in the pronephros. At tailbud stage (stage 25-28), expression is high in the anterior-most branchial arch and pronephric glomus. At stage 40, staining persists in the glomus and in the epicardium region of the heart, and at stage 42, expression is higher in the glomus than in the kidney tubule or duct. In adults, expression is highest in the rectum and the spleen, with significant expression in the duodenum, heart, kidney, lungs, pancreas, skin, liver and muscle.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Expression begins at the start of neurulation (stage 13), followed by a gradual increase in expression from stages 16.5 to 26.5, after which expression levels are maintained through to stage 35.
messages: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis.
messages: Nucleus

8355:dhx8.S
gene id: 8355:dhx8.S
uniprot id: A0A8J1LZR9
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108718502
gene id: 8355:LOC108718502
uniprot id: A0A8J0VJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8355:aurkb.L
gene id: 8355:aurkb.L
uniprot id: A0A8J0UNB3
uniprot id: Q6DE08
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Chromosome
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts directly (via N-terminus and kinase domain) with incenp (via C terminus), and may weakly interact (via N-terminus) with birc5.1 to stabilize the complex. Interacts with mtus1.
messages: Kinase activity is stimulated by both birc5/survivin-binding and cell-cycle specific phosphorylation.
messages: Nucleus
messages: Phosphorylated, stimulates kinase activity.
messages: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Phosphorylates 'Ser-10' of histone H3 during mitosis.

8355:tha1p.L
gene id: 8355:tha1p.L
uniprot id: A0A8J0TWJ0
names: Similarity
messages: Belongs to the threonine aldolase family.

8355:rpl23.S
gene id: 8355:rpl23.S
uniprot id: Q6GNH1
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

8355:cops9.L
gene id: 8355:cops9.L
uniprot id: A0A1L8GBE1
names: Similarity
messages: Belongs to the CSN9 family.

8355:LOC121397673
gene id: 8355:LOC121397673
uniprot id: A0A8J1LME3
names: Subcellular Location Annotation
messages: Membrane

8355:dao.L
gene id: 8355:dao.L
uniprot id: A0A1L8HZZ7
uniprot id: A0A1L8HZZ9
uniprot id: Q4QR47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

8355:wars1.S
gene id: 8355:wars1.S
uniprot id: Q7ZWT7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8355:braf.S
gene id: 8355:braf.S
uniprot id: A0A1L8GQP3
uniprot id: A0A8J0UUA5
uniprot id: A0A8J0UUE1
uniprot id: A0A8J0UXR4
uniprot id: Q767H5
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

8355:cyba.L
gene id: 8355:cyba.L
uniprot id: Q6AZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

8355:gpr45.L
gene id: 8355:gpr45.L
uniprot id: P79945
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Highly selective receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
messages: Ubiquitously expressed.

8355:fam126a.S
gene id: 8355:fam126a.S
uniprot id: A0A1L8FR91
uniprot id: A0A8J0VPU6
uniprot id: A0A8J1L3B2
uniprot id: Q6NRA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

8355:crygdl.2.L
gene id: 8355:crygdl.2.L
uniprot id: A0A1L8HWX5
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:yipf5.S
gene id: 8355:yipf5.S
uniprot id: A0A1L8GV85
uniprot id: Q7SXS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.
messages: cis-Golgi network membrane

8355:LOC108710730
gene id: 8355:LOC108710730
uniprot id: A0A1L8GW72
uniprot id: A0A8J0USX9
uniprot id: A0A8J1MJ74
uniprot id: A0A8J1MK68
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108709410
gene id: 8355:LOC108709410
uniprot id: A0A1L8H6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

8355:gnpnat1.L
gene id: 8355:gnpnat1.L
uniprot id: Q7T0Z6
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

8355:LOC121398056
gene id: 8355:LOC121398056
uniprot id: A0A8J1LSM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:LOC108709530
gene id: 8355:LOC108709530
uniprot id: A0A1L8H7F0
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108707594
gene id: 8355:LOC108707594
uniprot id: A0A8J1M6C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:agmat.S
gene id: 8355:agmat.S
uniprot id: Q5HZ88
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

8355:bcl2l2.L
gene id: 8355:bcl2l2.L
uniprot id: Q6GP82
names: Similarity
messages: Belongs to the Bcl-2 family.

8355:bmt2.L
gene id: 8355:bmt2.L
uniprot id: A0A1L8GYV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

8355:LOC108705416
gene id: 8355:LOC108705416
uniprot id: A0A1L8HRS7
uniprot id: A0A8J1M5E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8355:LOC108719485
gene id: 8355:LOC108719485
uniprot id: A0A1L8HST2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cryga.2.L
gene id: 8355:cryga.2.L
uniprot id: A0A1L8EX11
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:c15orf40.L
gene id: 8355:c15orf40.L
uniprot id: Q5HZ71
names: Similarity
messages: Belongs to the UPF0235 family.

8355:foxn3.L
gene id: 8355:foxn3.L
uniprot id: A0A1L8F9H2
uniprot id: A0A8J0TGS2
uniprot id: B7ZQU4
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108714564
gene id: 8355:LOC108714564
uniprot id: A0A1L8GP26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

8355:tceanc.L
gene id: 8355:tceanc.L
uniprot id: A0A1L8HGG8
names: Subcellular Location Annotation
messages: Nucleus

8355:nus1.L
gene id: 8355:nus1.L
uniprot id: A0A1L8G8Z5
uniprot id: A0A8J0VAV7
names: Similarity
messages: Belongs to the UPP synthase family.

8355:slc16a12.L
gene id: 8355:slc16a12.L
uniprot id: A0A8J1L547
uniprot id: A0A8J1L548
names: Subcellular Location Annotation
messages: Membrane

8355:nfil3.L
gene id: 8355:nfil3.L
uniprot id: Q66J36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Cytoplasm
messages: Homodimer (By similarity). Binds DNA as a dimer (By similarity).
messages: May act as a transcriptional regulator of a number of proteins of the circadian clock.
messages: Nucleus

8355:LOC108700597
gene id: 8355:LOC108700597
uniprot id: A0A8J1LN77
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:lhpp.S
gene id: 8355:lhpp.S
uniprot id: Q3B8E3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity).

8355:uqcrq.S
gene id: 8355:uqcrq.S
uniprot id: Q2TAT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

8355:arl4c.S
gene id: 8355:arl4c.S
uniprot id: A0A8J1LYZ9
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8355:phlda2.L
gene id: 8355:phlda2.L
uniprot id: A1L2W9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHLDA2 family.
messages: Cytoplasm
messages: Membrane
messages: Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).
messages: The PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).

8355:dna2.S
gene id: 8355:dna2.S
uniprot id: Q8QHA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing (By similarity). Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of dna2 on the flap, helping the nuclease function.
messages: Mitochondrion
messages: Nucleus

8355:LOC108703466
gene id: 8355:LOC108703466
uniprot id: A0A8J0U337
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108717086
gene id: 8355:LOC108717086
uniprot id: A0A1L8GB47
names: Similarity
messages: Belongs to the dysbindin family.

8355:peli1.L
gene id: 8355:peli1.L
uniprot id: A0A1L8G719
uniprot id: A0A8J0VFH3
names: Similarity
messages: Belongs to the pellino family.

8355:arpc5.S
gene id: 8355:arpc5.S
uniprot id: Q641B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Nucleus
messages: cytoskeleton

8355:LOC108696313
gene id: 8355:LOC108696313
uniprot id: A0A8J1L8U6
names: Similarity
messages: Belongs to the MS4A family.

8355:LOC121393168
gene id: 8355:LOC121393168
uniprot id: A0A8J1KHH6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:slitrk2.L
gene id: 8355:slitrk2.L
uniprot id: A0A1L8F7N3
names: Similarity
messages: Belongs to the SLITRK family.

8355:LOC108715678
gene id: 8355:LOC108715678
uniprot id: A0A1L8GGD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8355:chmp2a.S
gene id: 8355:chmp2a.S
uniprot id: A0A1L8FGJ6
names: Similarity
messages: Belongs to the SNF7 family.

8355:LOC108709947
gene id: 8355:LOC108709947
uniprot id: A0A8J0UE52
uniprot id: A0A8J0UM60
names: Subcellular Location Annotation
messages: Membrane

8355:cep57.S
gene id: 8355:cep57.S
uniprot id: A0A1L8HAZ6
names: Similarity
messages: Belongs to the translokin family.

8355:ccdc85a.L
gene id: 8355:ccdc85a.L
uniprot id: A0A1L8G744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

8355:aurka.S
gene id: 8355:aurka.S
uniprot id: Q91819
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Interacts with kif2c and kif11.
messages: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression (By similarity). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (By similarity). Phosphorylates numerous target proteins (By similarity). Important for microtubule formation and/or stabilization (By similarity).
messages: Phosphorylated (By similarity). Autophosphorylated on a serine residue (By similarity).
messages: centrosome
messages: spindle pole

8355:LOC108704986
gene id: 8355:LOC108704986
uniprot id: A0A8J1M6F6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108697191
gene id: 8355:LOC108697191
uniprot id: A0A8J0TBA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:rsl24d1.L
gene id: 8355:rsl24d1.L
uniprot id: Q6GNL0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

8355:sycp2l.L
gene id: 8355:sycp2l.L
uniprot id: A0A8J0VJP2
uniprot id: A0A8J0VKU6
uniprot id: A0A8J0VP18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYCP2 family.
messages: Nucleus

8355:tuba5.L
gene id: 8355:tuba5.L
uniprot id: A0A1L8HEI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8355:tvp23b.L
gene id: 8355:tvp23b.L
uniprot id: A0A8J0TSJ3
uniprot id: A0A8J1LQM6
uniprot id: Q7SZ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

8355:LOC121397893
gene id: 8355:LOC121397893
uniprot id: A0A8J1LQS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8355:XB5807236.L
gene id: 8355:XB5807236.L
uniprot id: A0A8J0UBR8
uniprot id: Q6P7G3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:ctnna1.L
gene id: 8355:ctnna1.L
uniprot id: A0A1L8GWT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: cytoskeleton

8355:tes.S
gene id: 8355:tes.S
uniprot id: A0A8J0UWI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: focal adhesion

8355:snu13.L
gene id: 8355:snu13.L
uniprot id: Q7ZWY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

8355:vps53.S
gene id: 8355:vps53.S
uniprot id: A0A1L8H870
uniprot id: A0A8J1MEA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

8355:sema3c.S
gene id: 8355:sema3c.S
uniprot id: Q5XGY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC108713452
gene id: 8355:LOC108713452
uniprot id: A0A8J1MW63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:scfd2.L
gene id: 8355:scfd2.L
uniprot id: A0A1L8HTQ6
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

8355:acap1.S
gene id: 8355:acap1.S
uniprot id: A0A8J0U4X5
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

8355:LOC121401140
gene id: 8355:LOC121401140
uniprot id: A0A8J1MI54
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC446916
gene id: 8355:LOC446916
uniprot id: A0A8J0UDG5
uniprot id: A0A8J1M9D7
uniprot id: Q3B8A3
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

8355:LOC108716416
gene id: 8355:LOC108716416
uniprot id: A0A8J0V663
uniprot id: A0A8J0V9X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm

8355:cox4i1.S
gene id: 8355:cox4i1.S
uniprot id: Q6GN62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

8355:LOC108699671
gene id: 8355:LOC108699671
uniprot id: A0A8J0TKR8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8355:rita1.L
gene id: 8355:rita1.L
uniprot id: A0A1L8I064
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RITA family.
messages: Cytoplasm
messages: Interacts with RBPJ/RBPSUH.
messages: Nucleus
messages: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

8355:LOC108704788
gene id: 8355:LOC108704788
uniprot id: A0A8J1KUW1
names: Similarity
messages: Belongs to the TBP family.

8355:tram1.L
gene id: 8355:tram1.L
uniprot id: Q6DED0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Endoplasmic reticulum membrane
messages: Stimulatory or required for the translocation of secretory proteins across the ER membrane.

8355:sat1.S
gene id: 8355:sat1.S
uniprot id: A1L2W8
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Homodimer.

8355:vamp2.S
gene id: 8355:vamp2.S
uniprot id: O57345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane

8355:rdh8.S
gene id: 8355:rdh8.S
uniprot id: A0A8J0UVA3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:LOC108699069
gene id: 8355:LOC108699069
uniprot id: A0A8J1LG44
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:itpka.S
gene id: 8355:itpka.S
uniprot id: A0A1L8EZR8
uniprot id: A0A8J0TNW8
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8355:tmprss5.L
gene id: 8355:tmprss5.L
uniprot id: A0A1L8FNW0
uniprot id: A0A8J1LAD3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rpl22.L
gene id: 8355:rpl22.L
uniprot id: P50886
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL22 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8355:itgb6.L
gene id: 8355:itgb6.L
uniprot id: A0A1L8EW13
uniprot id: A0A8J0TUZ1
uniprot id: A0A8J0TW44
uniprot id: A0A8J1LUL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

8355:rps4x.S
gene id: 8355:rps4x.S
uniprot id: P49401
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

8355:parg.L
gene id: 8355:parg.L
uniprot id: A0A8J1L4R9
uniprot id: Q4KLP9
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

8355:cd151.L
gene id: 8355:cd151.L
uniprot id: Q6DDI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC108700843
gene id: 8355:LOC108700843
uniprot id: A0A1L8ESA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:cope.S
gene id: 8355:cope.S
uniprot id: Q6GR46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:fam110d.L
gene id: 8355:fam110d.L
uniprot id: A0A8J0QDQ0
names: Similarity
messages: Belongs to the FAM110 family.

8355:LOC108716124
gene id: 8355:LOC108716124
uniprot id: A0A8J1KN10
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:alkbh5.L
gene id: 8355:alkbh5.L
uniprot id: A0A1L8EYM3
names: Subcellular Location Annotation
names: Subunit
messages: Monomer.
messages: Nucleus speckle

8355:ppib.S
gene id: 8355:ppib.S
uniprot id: Q5XGR3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8355:mettl2b.L
gene id: 8355:mettl2b.L
uniprot id: A0A8J1LRZ6
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

8355:adam17.S
gene id: 8355:adam17.S
uniprot id: A0A1L8G4Z1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC121395394
gene id: 8355:LOC121395394
uniprot id: A0A8J1L5D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

8355:gchfr.L
gene id: 8355:gchfr.L
uniprot id: Q6GM84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GFRP family.
messages: Homopentamer. Forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers (By similarity).
messages: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1.
messages: Nucleus
messages: Nucleus membrane
messages: cytosol

8355:tnfrsf21.S
gene id: 8355:tnfrsf21.S
uniprot id: A0A8J1KXN5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108703573
gene id: 8355:LOC108703573
uniprot id: A0A8J1MU03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

8355:fat2.S
gene id: 8355:fat2.S
uniprot id: A0A1L8GQT2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ppp1r1c.L
gene id: 8355:ppp1r1c.L
uniprot id: A0A1L8EWM0
uniprot id: A0A8J0TTL8
uniprot id: A0A8J1LQ85
uniprot id: Q3KQ02
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

8355:LOC121400072
gene id: 8355:LOC121400072
uniprot id: A0A8J1MC73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108698619
gene id: 8355:LOC108698619
uniprot id: A0A1L8F8U7
uniprot id: A0A8J0THP7
names: Function
messages: Plays a role in the process of neurogenesis.

8355:cystm1.L
gene id: 8355:cystm1.L
uniprot id: A0A1L8GXA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

8355:LOC121393680
gene id: 8355:LOC121393680
uniprot id: A0A8J1KN60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

8355:psmg1.L
gene id: 8355:psmg1.L
uniprot id: Q05AX3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Degraded by the proteasome upon completion of 20S proteasome maturation.
messages: Endoplasmic reticulum
messages: Forms a heterodimer with psmg2.

8355:olfml3.S
gene id: 8355:olfml3.S
uniprot id: A0A1L8H6G3
uniprot id: A0A8J0UIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Secreted

8355:ptgs2.L
gene id: 8355:ptgs2.L
uniprot id: A0A1L8GNN4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

8355:abhd17c.S
gene id: 8355:abhd17c.S
uniprot id: Q6DD70
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization.
messages: Postsynaptic density membrane
messages: Recycling endosome membrane
messages: dendritic spine

8355:chrna1.L
gene id: 8355:chrna1.L
uniprot id: A0A8J0TIS1
uniprot id: Q7ZTL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:fzd6.L
gene id: 8355:fzd6.L
uniprot id: A0A1L8FZR1
uniprot id: A0A8J0VI00
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108705690
gene id: 8355:LOC108705690
uniprot id: A0A8J1LWF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:fam189a2.L
gene id: 8355:fam189a2.L
uniprot id: A0A1L8HYK5
uniprot id: A0A8J1KTQ1
names: Similarity
messages: Belongs to the ENTREP family.

8355:LOC108702983
gene id: 8355:LOC108702983
uniprot id: A0A1L8EP89
uniprot id: A0A8J0U0M1
uniprot id: A0A8J1LYI4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

8355:nudt19.L
gene id: 8355:nudt19.L
uniprot id: Q5PQ50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).
messages: Monomer.
messages: Peroxisome

8355:LOC108705586
gene id: 8355:LOC108705586
uniprot id: A0A8J0TZ77
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:wdr61.L
gene id: 8355:wdr61.L
uniprot id: Q6GMD2
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PAF1 complex, which at least consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8 (By similarity). The PAF1 complex interacts with PHF5A (By similarity).
messages: Cytoplasm
messages: Nucleus

8355:rnf13.L
gene id: 8355:rnf13.L
uniprot id: Q6P414
names: Subcellular Location Annotation
messages: Membrane

8355:pde6b.L
gene id: 8355:pde6b.L
uniprot id: A0A1L8HVK6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:fam124b.S
gene id: 8355:fam124b.S
uniprot id: A0A1L8G4H2
names: Similarity
messages: Belongs to the FAM124 family.

8355:rps9.L
gene id: 8355:rps9.L
uniprot id: A0A1L8FNQ9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

8355:ecrg4.L
gene id: 8355:ecrg4.L
uniprot id: Q7ZXZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Probable hormone that may attenuate cell proliferation and induce senescence in the central nervous system.
messages: Secreted

8355:XB941699.L
gene id: 8355:XB941699.L
uniprot id: A9JS18
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8355:chga.L
gene id: 8355:chga.L
uniprot id: A0A1L8F9I6
uniprot id: A0A8J0TI53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

8355:dcaf12.S
gene id: 8355:dcaf12.S
uniprot id: Q6AX81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat DCAF12 family.
messages: Component of the DCX(DCAF12) E3 ubiquitin ligase complex, at least composed of cul4 (cul4a or cul4b), ddb1, dcaf12 and rbx1.
messages: Cytoplasm
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, leading to their ubiquitination and degradation.
messages: centrosome

8355:tor1a.L
gene id: 8355:tor1a.L
uniprot id: Q6AZG2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum lumen
messages: Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane.
messages: Membrane
messages: growth cone

8355:LOC108711439
gene id: 8355:LOC108711439
uniprot id: A0A1L8H102
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

8355:tmem129.L
gene id: 8355:tmem129.L
uniprot id: A0A1L8HT77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

8355:LOC121393140
gene id: 8355:LOC121393140
uniprot id: Q7SZB0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

8355:tph2.S
gene id: 8355:tph2.S
uniprot id: A0A1L8GUD7
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

8355:xkr6.S
gene id: 8355:xkr6.S
uniprot id: A0A1L8G5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

8355:LOC121393212
gene id: 8355:LOC121393212
uniprot id: A0A1L8HW37
uniprot id: A0A8J1KLD1
names: Similarity
messages: Belongs to the GIPC family.

8355:LOC108700810
gene id: 8355:LOC108700810
uniprot id: A0A8J0TKA1
names: Similarity
messages: Belongs to the SNF8 family.

8355:stambpl1.S
gene id: 8355:stambpl1.S
uniprot id: A0A8J0TEA0
uniprot id: Q6NU03
names: Similarity
messages: Belongs to the peptidase M67C family.

8355:casr.S
gene id: 8355:casr.S
uniprot id: A0A1L8H5K9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:fmr1.L
gene id: 8355:fmr1.L
uniprot id: P51113
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Chromosome
messages: Cytoplasmic ribonucleoprotein granule
messages: During early to late tailbud stage, expression intensifies in the craniofacial region with prominent staining in the endodermal, mesodermal and mesenchymal regions of the pharyngeal arches. By early tadpole stage (stage 35), expressed in the forebrain, midbrain, hindbrain and notochord in addition to craniofacial regions including the ear vesicles and eye. In the central nervous system (CNS) of late tadpoles (stage 45), expressed in the olfactory bulbs and the cerebellum. In adults, expressed predominantly in the brain.
messages: Expressed both maternally and zygotically. Zygotic expression begins just prior to gastrulation (stage 10) and gradually increases during subsequent embryonic stages.
messages: Homodimer. Heterodimer.
messages: Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs (By similarity). Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C).
messages: Nucleus
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Presynaptic cell membrane
messages: Stress granule
messages: Synapse
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

8355:bc014685.S
gene id: 8355:bc014685.S
uniprot id: A0A1L8FF36
names: Subcellular Location Annotation
messages: Membrane

8355:ighmbp2.L
gene id: 8355:ighmbp2.L
uniprot id: A0A1L8GJ95
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

8355:brd1.S
gene id: 8355:brd1.S
uniprot id: A0A1L8GU33
uniprot id: A0A8J0UR36
uniprot id: A0A8J0UXK3
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108719971
gene id: 8355:LOC108719971
uniprot id: A0A8J0VQE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121397618
gene id: 8355:LOC121397618
uniprot id: A0A8J1LM03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:actr5.S
gene id: 8355:actr5.S
uniprot id: A0A1L8EML1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP5 subfamily.
messages: Nucleus

8355:chst9l.1.S
gene id: 8355:chst9l.1.S
uniprot id: A0A1L8EZS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:rc3h1.L
gene id: 8355:rc3h1.L
uniprot id: Q6NUC6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: HEPN (higher eukaryotes and prokaryotes nucleotide-binding) are observed in both N- and C-terminal sides of ROQ domain with 3D structure even if they are poredcted on the basis of sequence.
messages: P-body
messages: Post-transcriptional repressor. May recognize and bind to the 3'-UTR of some mRNAs and promote mRNA decay.
messages: Proteolytically cleaved after Arg-509 and Arg-576 by MALT1 in activated CD4(+) T cells; cleavage at Arg-509 and Arg-576 is critical for promoting RC3H1 degradation in response to T-cell receptor (TCR) stimulation, and hence is necessary for prolonging the stability of a set of mRNAs controlling Th17 cell differentiation.
messages: The RING-type zinc finger is required for proper localization to stress granules, but not to P-bodies.
messages: The ROQ region is required for CDE RNA-binding. It may also be involved in localization to stress granules.

8355:sh3bgrl3.S
gene id: 8355:sh3bgrl3.S
uniprot id: Q6NTS6
names: Similarity
messages: Belongs to the SH3BGR family.

8355:wdr82.S
gene id: 8355:wdr82.S
uniprot id: A0A1L8GHF9
uniprot id: Q58E77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SWD2 family.
messages: Chromosome
messages: Component of the SET1 complex.
messages: Nucleus
messages: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

8355:tpte2.S
gene id: 8355:tpte2.S
uniprot id: A0A1L8HAD6
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

8355:LOC108715589
gene id: 8355:LOC108715589
uniprot id: A0A1L8GFU7
uniprot id: A0A8J0V661
uniprot id: A0A8J0V6Y1
uniprot id: A0A8J1KJ82
uniprot id: A0A8J1KJ95
uniprot id: A0A8J1KJA5
uniprot id: A0A8J1KKZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

8355:kcnc3.L
gene id: 8355:kcnc3.L
uniprot id: Q642Q0
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121399727
gene id: 8355:LOC121399727
uniprot id: A0A8J1M848
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

8355:actn2.S
gene id: 8355:actn2.S
uniprot id: Q6IP14
names: Similarity
messages: Belongs to the alpha-actinin family.

8355:LOC108718598
gene id: 8355:LOC108718598
uniprot id: A0A8J1KWC4
names: Subcellular Location Annotation
messages: Nucleus

8355:adra1a.L
gene id: 8355:adra1a.L
uniprot id: A0A1L8H1B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: caveola

8355:eif4g1.S
gene id: 8355:eif4g1.S
uniprot id: A0A1L8G3I1
uniprot id: A0A8J0VDY6
uniprot id: A0A8J0VJ95
uniprot id: B1WBA6
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

8355:gsc.S
gene id: 8355:gsc.S
uniprot id: P53546
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Induced by activin (even in the absence of protein synthesis), lithium chloride, nodal/nr-1, nodal2/nr-2 and derriere. Not affected by basic fibroblast growth factor, and repressed by retinoic acid, and by UV light.
messages: Nucleus
messages: Plays a central role in executing Spemann's organizer phenomenon (the dorsal blastopore lip of the early Xenopus laevis gastrula can organize a complete secondary body axis when transplanted to another embryo).

8355:MGC68655
gene id: 8355:MGC68655
uniprot id: Q6PBB4
names: Similarity
messages: Belongs to the SUI1 family.

8355:LOC121399924
gene id: 8355:LOC121399924
uniprot id: A0A8J1M893
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:LOC121399188
gene id: 8355:LOC121399188
uniprot id: A0A8J1M081
uniprot id: A0A8J1M245
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8355:napb.S
gene id: 8355:napb.S
uniprot id: A0A8J0TEW1
uniprot id: Q6AZJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

8355:plod1.L
gene id: 8355:plod1.L
uniprot id: Q5XGZ0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8355:cops5.S
gene id: 8355:cops5.S
uniprot id: Q6GLM9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Nucleus
messages: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex.
messages: The CSN complex is associated with some 'Lys-63'-specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the brcc3/brcc36 component of the BRISC complex (By similarity).
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).
messages: cytosol
messages: perinuclear region
messages: synaptic vesicle

8355:colec11.L
gene id: 8355:colec11.L
uniprot id: Q7T0T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COLEC10/COLEC11 family.
messages: Homotrimer; disulfide-linked. Interacts with MASP1; probably triggers the lectin pathway of complement.
messages: Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.
messages: Secreted

8355:ndufa13.L
gene id: 8355:ndufa13.L
uniprot id: Q66KN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

8355:nes.L
gene id: 8355:nes.L
uniprot id: A0A1L8FCC8
names: Similarity
messages: Belongs to the intermediate filament family.

8355:cyb5d1.L
gene id: 8355:cyb5d1.L
uniprot id: Q5PPR6
names: Similarity
messages: Belongs to the cytochrome b5 family.

8355:ccr3.L
gene id: 8355:ccr3.L
uniprot id: A0A1L8FX05
uniprot id: A0A8J0VI74
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:tjap1.L
gene id: 8355:tjap1.L
uniprot id: A0A8J1KLT2
uniprot id: A0A8J1KLU4
uniprot id: A0A8J1KPW8
uniprot id: Q2TAS0
names: Subcellular Location Annotation
messages: Membrane

8355:MGC83663
gene id: 8355:MGC83663
uniprot id: A0A8J0TR89
uniprot id: A0A8J1LR56
uniprot id: A0A8J1LS58
uniprot id: Q6GN03
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

8355:atad1.S
gene id: 8355:atad1.S
uniprot id: A0A1L8FE19
uniprot id: A0A8J0TBK9
names: Similarity
messages: Belongs to the AAA ATPase family.

8355:LOC121393120
gene id: 8355:LOC121393120
uniprot id: A0A8J1M7Z5
uniprot id: A0A8J1M8T3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121395599
gene id: 8355:LOC121395599
uniprot id: A0A8J1L8U5
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:armc1.L
gene id: 8355:armc1.L
uniprot id: A0A1L8FZ74
uniprot id: Q6DFC9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

8355:nit2.S
gene id: 8355:nit2.S
uniprot id: A0A8J0UIT3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

8355:LOC108717166
gene id: 8355:LOC108717166
uniprot id: A0A1L8GBI0
uniprot id: A0A1L8GBR1
uniprot id: A0A8J1KQ64
uniprot id: A0A8J1KQ70
uniprot id: A0A8J1KQ73
uniprot id: A0A8J1KQ77
uniprot id: A0A8J1KRS1
uniprot id: A0A8J1KTB2
uniprot id: A0A8J1KTB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

8355:LOC108700335
gene id: 8355:LOC108700335
uniprot id: A0A1L8F4H7
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:ttc39b.S
gene id: 8355:ttc39b.S
uniprot id: A0A8J1M2X2
uniprot id: A0A8J1M4S1
names: Similarity
messages: Belongs to the TTC39 family.

8355:trappc4.S
gene id: 8355:trappc4.S
uniprot id: A0A8J0U6D4
uniprot id: Q3B8F1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

8355:atp13a5l.3.L
gene id: 8355:atp13a5l.3.L
uniprot id: A0A8J0VCV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

8355:LOC108712710
gene id: 8355:LOC108712710
uniprot id: A0A1L8GRQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108708637
gene id: 8355:LOC108708637
uniprot id: A0A1L8HIE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:asphd2.S
gene id: 8355:asphd2.S
uniprot id: A0A1L8HQ61
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

8355:aldob.L
gene id: 8355:aldob.L
uniprot id: A0A8J1LRQ9
uniprot id: Q9DGE5
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

8355:LOC108715732
gene id: 8355:LOC108715732
uniprot id: A0A8J0V6S5
names: Similarity
messages: Belongs to the BRINP family.

8355:tmem63a.S
gene id: 8355:tmem63a.S
uniprot id: Q5PQ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

8355:bin3.L
gene id: 8355:bin3.L
uniprot id: Q5PPZ5
names: Function
names: Subcellular Location Annotation
messages: Involved in cytokinesis and septation where it has a role in the localization of F-actin.
messages: cytoskeleton

8355:LOC108713014
gene id: 8355:LOC108713014
uniprot id: A0A1L8GTK6
uniprot id: A0A8J1MRA1
uniprot id: A0A8J1MSA6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynaptic density

8355:snx7.L
gene id: 8355:snx7.L
uniprot id: A0A1L8GMU7
names: Similarity
messages: Belongs to the sorting nexin family.

8355:chrdl1.L
gene id: 8355:chrdl1.L
uniprot id: A0A8J1LGI7
names: Subcellular Location Annotation
messages: Secreted

8355:LOC121399155
gene id: 8355:LOC121399155
uniprot id: A0A8J1M1Y5
names: Similarity
messages: Belongs to the cyclin family.

8355:gstm1.S
gene id: 8355:gstm1.S
uniprot id: Q7SZ23
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

8355:gata3.L
gene id: 8355:gata3.L
uniprot id: A0A1L8GZE8
uniprot id: A0A8J0UJ87
uniprot id: A0A8J0UQD5
uniprot id: A0A8J0URL6
names: Subcellular Location Annotation
messages: Nucleus

8355:b4galt2.L
gene id: 8355:b4galt2.L
uniprot id: A0A1L8GM82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:slc19a3.L
gene id: 8355:slc19a3.L
uniprot id: A0A8J1KQ04
uniprot id: A0A8J1KQ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

8355:dnah7.L
gene id: 8355:dnah7.L
uniprot id: A0A8J1LUB2
uniprot id: A0A8J1LUB6
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:fam83h.S
gene id: 8355:fam83h.S
uniprot id: A0A1L8FUB4
names: Similarity
messages: Belongs to the FAM83 family.

8355:LOC108702649
gene id: 8355:LOC108702649
uniprot id: A0A1L8ELU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:slc19a3.2.L
gene id: 8355:slc19a3.2.L
uniprot id: A0A1L8GAZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

8355:chd1.S
gene id: 8355:chd1.S
uniprot id: A0A1L8HR49
uniprot id: A0A1L8HR66
uniprot id: A0A8J0UAT5
names: Subcellular Location Annotation
messages: Nucleus

8355:cdh13.L
gene id: 8355:cdh13.L
uniprot id: Q5XHE3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

8355:c6orf120.S
gene id: 8355:c6orf120.S
uniprot id: A0A8J0VEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: Secreted

8355:pmf1.L
gene id: 8355:pmf1.L
uniprot id: A0A8J0PTF6
uniprot id: Q6NTS5
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

8355:cyp26a1.S
gene id: 8355:cyp26a1.S
uniprot id: Q6GNJ2
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108710935
gene id: 8355:LOC108710935
uniprot id: A0A1L8GXL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8355:cluap1.L
gene id: 8355:cluap1.L
uniprot id: A0A1L8EYI0
uniprot id: A0A8J0TTQ2
uniprot id: A0A8J1LRL9
uniprot id: Q5PPY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

8355:zp4.2.L
gene id: 8355:zp4.2.L
uniprot id: A0A1L8HCW0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:sh3bgrl.S
gene id: 8355:sh3bgrl.S
uniprot id: A0A1L8F379
uniprot id: A0A8J0TQP7
names: Similarity
messages: Belongs to the SH3BGR family.

8355:mcm2.S
gene id: 8355:mcm2.S
uniprot id: A0A1L8GHP1
uniprot id: A0A8J0V813
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

8355:LOC108710543
gene id: 8355:LOC108710543
uniprot id: A0A1L8H4J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:slc38a7.L
gene id: 8355:slc38a7.L
uniprot id: Q6DFE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Lysosome membrane
messages: Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen.
messages: axon

8355:mfsd14a.S
gene id: 8355:mfsd14a.S
uniprot id: Q6GPT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8355:XB985134.L
gene id: 8355:XB985134.L
uniprot id: A0A1L8FZF1
uniprot id: A0A8J1KYT5
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108710043
gene id: 8355:LOC108710043
uniprot id: A0A1L8HB89
uniprot id: A0A8J0UMH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

8355:cox6a1.S
gene id: 8355:cox6a1.S
uniprot id: A0A1L8HQ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

8355:naf1.L
gene id: 8355:naf1.L
uniprot id: A0A8J0TCY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

8355:aoc3.L
gene id: 8355:aoc3.L
uniprot id: A0A8J1LPY7
uniprot id: Q6DCR9
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

8355:slc25a22.L
gene id: 8355:slc25a22.L
uniprot id: A0A1L8GJH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:galnt12.L
gene id: 8355:galnt12.L
uniprot id: A0A1L8FX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:atp6v0c.L
gene id: 8355:atp6v0c.L
uniprot id: Q7SYU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

8355:dld.S
gene id: 8355:dld.S
uniprot id: Q7T0W0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

8355:LOC121394550
gene id: 8355:LOC121394550
uniprot id: A0A8J1KX40
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108707348
gene id: 8355:LOC108707348
uniprot id: A0A8J0UB49
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

8355:srd5a2.L
gene id: 8355:srd5a2.L
uniprot id: A0A1L8G8B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane
messages: Microsome membrane

8355:LOC108712716
gene id: 8355:LOC108712716
uniprot id: A0A8J0UW14
uniprot id: A0A8J0UZG4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:parp10.S
gene id: 8355:parp10.S
uniprot id: A0A1L8FU83
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:stk17a.S
gene id: 8355:stk17a.S
uniprot id: Q52KW9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:pdpr.S
gene id: 8355:pdpr.S
uniprot id: A0A1L8GF20
names: Similarity
messages: Belongs to the GcvT family.

8355:max.S
gene id: 8355:max.S
uniprot id: A0A8J1LK78
uniprot id: A0A8J1LLH1
uniprot id: A0A8J1LMP2
uniprot id: B7ZPF6
uniprot id: Q07016
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: All four alternatively spliced forms are present during development and in all adult tissues examined.
messages: Belongs to the MAX family.
messages: Efficient DNA binding requires dimerization with another bHLH protein. MYC/MAX heterodimers bind to target DNA with high affinity. MAX may also form homodimers which recognize the same target sequence, but which are unable to function as transcription activators. Component of some MLL1/MLL complex (By similarity).
messages: Nucleus
messages: Phosphorylated.
messages: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity).

8355:phlda1.L
gene id: 8355:phlda1.L
uniprot id: A1L2R3
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108703572
gene id: 8355:LOC108703572
uniprot id: A0A8J0U5E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: centriole

8355:acvr1c.S
gene id: 8355:acvr1c.S
uniprot id: A0A1L8EP06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8355:dgka.S
gene id: 8355:dgka.S
uniprot id: A0A8J1MFL4
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8355:stim1.L
gene id: 8355:stim1.L
uniprot id: A0A8J1M5V7
uniprot id: A0A8J1M5V8
uniprot id: A0A8J1M5W2
uniprot id: A0A8J1M5W4
uniprot id: A0A8J1M5X1
uniprot id: A0A8J1M5X6
uniprot id: A0A8J1M5Y1
uniprot id: A0A8J1M6X5
uniprot id: A0A8J1M6Y0
uniprot id: A0A8J1M6Y5
uniprot id: A0A8J1M7P9
uniprot id: A0A8J1M7Q4
uniprot id: A0JMU6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108699286
gene id: 8355:LOC108699286
uniprot id: A0A1L8FB68
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:XB964897.L
gene id: 8355:XB964897.L
uniprot id: A0A1L8GMZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8355:LOC121395494
gene id: 8355:LOC121395494
uniprot id: A0A1L8FMU1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ddx46.L
gene id: 8355:ddx46.L
uniprot id: A0A8J0UNW0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:tmem267.L
gene id: 8355:tmem267.L
uniprot id: Q6DED9
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121401338
gene id: 8355:LOC121401338
uniprot id: A0A8J1MIU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121397175
gene id: 8355:LOC121397175
uniprot id: A0A8J1LIM2
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:exoc3l1.L
gene id: 8355:exoc3l1.L
uniprot id: A0A1L8GLG6
uniprot id: A0A8J0V5R1
names: Similarity
messages: Belongs to the SEC6 family.

8355:esyt3.L
gene id: 8355:esyt3.L
uniprot id: A0A1L8EV65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108699282
gene id: 8355:LOC108699282
uniprot id: A0A1L8FB50
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

8355:myg1.S
gene id: 8355:myg1.S
uniprot id: Q3KPM3
names: Similarity
messages: Belongs to the MYG1 family.

8355:sgsm3.S
gene id: 8355:sgsm3.S
uniprot id: A0A8J0V336
uniprot id: A0A8J0V4C2
uniprot id: A0A8J1MYT1
uniprot id: A6H8I2
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

8355:fbxo9.L
gene id: 8355:fbxo9.L
uniprot id: A0A8J0V4K1
uniprot id: A0A8J0V7V9
uniprot id: A0A8J1KL34
uniprot id: Q7SY92
names: Subcellular Location Annotation
messages: Cytoplasm

8355:nudt6.L
gene id: 8355:nudt6.L
uniprot id: P13420
uniprot id: Q7ZY23
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: Detected in liver (at protein level).
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus
messages: This protein is coded from a FGF2 (BFGF) gene antisense transcript.

8355:pofut2.L
gene id: 8355:pofut2.L
uniprot id: A0A1L8EWV8
uniprot id: A0A8J0TVE1
names: Similarity
messages: Belongs to the glycosyltransferase 68 family.

8355:LOC108717074
gene id: 8355:LOC108717074
uniprot id: A0A1L8GAQ5
uniprot id: A0A8J1KSY3
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8355:wdr12.S
gene id: 8355:wdr12.S
uniprot id: A0A1L8EPU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

8355:lhx2.S
gene id: 8355:lhx2.S
uniprot id: Q6K1E8
names: Subcellular Location Annotation
messages: Nucleus

8355:glud1.L
gene id: 8355:glud1.L
uniprot id: A0A1L8FK58
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

8355:LOC108705817
gene id: 8355:LOC108705817
uniprot id: A0A8J1LGI9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:adm.S
gene id: 8355:adm.S
uniprot id: A0A1L8GDP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

8355:eef2.1.L
gene id: 8355:eef2.1.L
uniprot id: Q7ZXP8
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

8355:ddx18.S
gene id: 8355:ddx18.S
uniprot id: A0A1L8ENF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: Cytoplasm
messages: Nucleus

8355:hoxb5.L
gene id: 8355:hoxb5.L
uniprot id: A0A8J0TSU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:tmem38b.S
gene id: 8355:tmem38b.S
uniprot id: Q3KQE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM38 family.
messages: Endoplasmic reticulum membrane
messages: Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

8355:top2b.L
gene id: 8355:top2b.L
uniprot id: A0A1L8FW96
uniprot id: A0A8J0VKA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

8355:LOC108705278
gene id: 8355:LOC108705278
uniprot id: A0A310UAW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

8355:ndufa3.L
gene id: 8355:ndufa3.L
uniprot id: Q66KR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

8355:LOC108700560
gene id: 8355:LOC108700560
uniprot id: A0A8J1LNE3
uniprot id: A0A8J1LNH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

8355:nr1h5.L
gene id: 8355:nr1h5.L
uniprot id: Q8JJ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8355:ilf3.S
gene id: 8355:ilf3.S
uniprot id: A0A8J0U1P0
uniprot id: Q2TAV5
uniprot id: Q91550
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A component of a ybx2/frgy2-containing mRNA-ribonucleoprotein (mRNP) complex. Also a component of the CCAAT box transcription factor (CBTF) complex.
messages: Cytoplasm
messages: Expressed both maternally and zygotically throughout early development (at protein level). Isoform 1 accumulates throughout oogenesis but isoform 2 is translationally masked until oocyte maturation.
messages: Expressed mainly in the ectoderm (at protein level).
messages: Methylated by protein arginine N-methyltransferase 1 (prmt1b) in the RGG-rich domain. Methylation decreases DNA-binding and thereby decreases transcription of the gata2 gene, but does not regulate dsRNA binding or subcellular localization.
messages: Nucleus
messages: Phosphorylated. Phosphorylation affects nuclear translocation.
messages: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons (By similarity). Plays thereby a role in the back-splicing of a subset of circRNAs (By similarity). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (By similarity). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (By similarity). Has a cytoplasmic role early in development as part of a ribonucleoprotein (mRNP) complex which may regulate mRNA transport and/or translation. Following nuclear localization at the mid-blastula transition, acts as a transcription factor and binds the 5'-CCAAT-3' promoter sequence to regulate transcription of the gata2 gene as a subunit of the CCAAT box transcription factor (CBTF). Its role as an mRNP component negatively regulates its activity as a transcription factor by precluding its nuclear localization (PubMed:10899122, PubMed:15452137, PubMed:18636753, PubMed:19665599, PubMed:7922339, PubMed:9710639).

8355:LOC121393601
gene id: 8355:LOC121393601
uniprot id: A0A8J1KMD2
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:lypd6b.S
gene id: 8355:lypd6b.S
uniprot id: A0A1L8ENY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:spty2d1.L
gene id: 8355:spty2d1.L
uniprot id: A0A1L8GI62
uniprot id: A0A8J1MUX3
names: Similarity
messages: Belongs to the SPT2 family.

8355:acat2.L
gene id: 8355:acat2.L
uniprot id: Q6INZ2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

8355:LOC108703524
gene id: 8355:LOC108703524
uniprot id: A0A8J0TUR8
names: Subunit
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

8355:LOC108718596
gene id: 8355:LOC108718596
uniprot id: A0A1L8FZS0
names: Subcellular Location Annotation
messages: Membrane

8355:xylt2.L
gene id: 8355:xylt2.L
uniprot id: A0A1L8EUE4
uniprot id: A0A8J0TWA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

8355:e2f1.S
gene id: 8355:e2f1.S
uniprot id: A0A1L8EMM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8355:pkm.L
gene id: 8355:pkm.L
uniprot id: A0A1L8H000
uniprot id: A0A8J1MGQ5
uniprot id: A0A8J1MHA0
uniprot id: Q7ZY25
names: Similarity
messages: Belongs to the pyruvate kinase family.

8355:apc.L
gene id: 8355:apc.L
uniprot id: A0A1L8I1P0
uniprot id: A0A8J0U0M7
uniprot id: P70039
names: Function
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.
messages: Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator.

8355:trmt61a.L
gene id: 8355:trmt61a.L
uniprot id: Q8AVK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

8355:rida.S
gene id: 8355:rida.S
uniprot id: A0A1L8FTH3
names: Function
names: Similarity
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.

8355:plpp4.L
gene id: 8355:plpp4.L
uniprot id: A0A8J1L4L9
uniprot id: Q5PQ58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:tm4sf1.L
gene id: 8355:tm4sf1.L
uniprot id: Q5U519
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8355:tnfsf11.L
gene id: 8355:tnfsf11.L
uniprot id: A0A1L8HHK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

8355:add3.S
gene id: 8355:add3.S
uniprot id: A0A1L8FDN2
uniprot id: A0A8J0T5A2
uniprot id: A0A8J0TDD2
uniprot id: A0A8J0TDD7
uniprot id: A0A8J0TE49
uniprot id: A0A8J1LB26
uniprot id: A0A8J1LDF8
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

8355:c8orf37.L
gene id: 8355:c8orf37.L
uniprot id: A0A1L8FZM7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

8355:gdf1.S
gene id: 8355:gdf1.S
uniprot id: Q5EAV2
names: Similarity
messages: Belongs to the TGF-beta family.

8355:pxn.L
gene id: 8355:pxn.L
uniprot id: A0A1L8I058
uniprot id: A0A8J0V8A4
uniprot id: A0A8J0VD11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

8355:LOC108710361
gene id: 8355:LOC108710361
uniprot id: A0A8J1MMY0
uniprot id: A0A8J1MQ10
names: Subcellular Location Annotation
messages: Membrane

8355:mfsd4a.L
gene id: 8355:mfsd4a.L
uniprot id: A0A1L8HEM4
names: Subcellular Location Annotation
messages: Membrane

8355:ndufb5.L
gene id: 8355:ndufb5.L
uniprot id: Q8AVD8
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.

8355:actl6a.S
gene id: 8355:actl6a.S
uniprot id: Q7ZYI5
names: Similarity
messages: Belongs to the actin family.

8355:rnf128.L
gene id: 8355:rnf128.L
uniprot id: Q8AWW4
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Auto-ubiquitinated.
messages: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains (By similarity). Converts epidermis into cement gland and neural tissue in whole embryos.
messages: Endomembrane system
messages: Expressed in the cement gland, cranial placodes, and the pronephros.
messages: Present as a maternal transcript. Early expression is confined to tissues of ectodermal origin. At stage 16, the predominant area of expression is within the developing cement gland. At stage 27, expression is detected in the anterodorsal lateral line placode, the olfactory placode, and the otic vesicle and pronephros.
messages: perinuclear region

8355:LOC108713200
gene id: 8355:LOC108713200
uniprot id: A0A1L8HXS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8355:LOC108713136
gene id: 8355:LOC108713136
uniprot id: A0A1L8GUB6
uniprot id: A0A8J0UXT5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

8355:dennd11.L
gene id: 8355:dennd11.L
uniprot id: Q4FZX0
names: Function
names: Similarity
messages: Belongs to the DENND11 family.
messages: Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form.

8355:dpy30.S
gene id: 8355:dpy30.S
uniprot id: Q6GQK3
names: Similarity
messages: Belongs to the dpy-30 family.

8355:gtf2a1.S
gene id: 8355:gtf2a1.S
uniprot id: A0A8J1LKG2
uniprot id: Q6XPY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Belongs to the TFIIA subunit 1 family.
messages: Cytoplasm
messages: Nucleus

8355:slitrk1.L
gene id: 8355:slitrk1.L
uniprot id: A0A1L8HH99
names: Similarity
messages: Belongs to the SLITRK family.

8355:c5orf24.S
gene id: 8355:c5orf24.S
uniprot id: A0A1L8GRC2
names: Similarity
messages: Belongs to the UPF0461 family.

8355:slc39a10.L
gene id: 8355:slc39a10.L
uniprot id: A0A1L8EX07
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121393570
gene id: 8355:LOC121393570
uniprot id: A0A8J1KLY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8355:tmem87a.S
gene id: 8355:tmem87a.S
uniprot id: A0A1L8F488
uniprot id: A0A8J0TRF2
names: Subcellular Location Annotation
messages: Membrane

8355:crebbp.L
gene id: 8355:crebbp.L
uniprot id: A0A1L8EYE5
uniprot id: A0A8J0TRM1
uniprot id: A0A8J0TSF0
uniprot id: A0A8J1LQ06
uniprot id: A0A8J1LQ46
uniprot id: A0A8J1LRE0
uniprot id: Q5U248
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108703703
gene id: 8355:LOC108703703
uniprot id: A0A8J0U3L5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108697599
gene id: 8355:LOC108697599
uniprot id: A0A8J0TEH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

8355:lypla1.S
gene id: 8355:lypla1.S
uniprot id: A0A1L8FT16
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

8355:LOC108697361
gene id: 8355:LOC108697361
uniprot id: Q6DFK8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:LOC108716231
gene id: 8355:LOC108716231
uniprot id: A0A1L8I0P6
uniprot id: A0A8J0V913
uniprot id: A0A8J0V9P8
uniprot id: A0A8J0VEI8
uniprot id: A0A8J1L0P3
names: Subcellular Location Annotation
messages: Nucleus

8355:tm4sf20.S
gene id: 8355:tm4sf20.S
uniprot id: A0A1L8G4V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8355:kif11.L
gene id: 8355:kif11.L
uniprot id: Q8AVK8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:pnn.S
gene id: 8355:pnn.S
uniprot id: A0A8J1LKE1
uniprot id: O73619
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

8355:gps1.S
gene id: 8355:gps1.S
uniprot id: Q4QQY0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:tnip2.L
gene id: 8355:tnip2.L
uniprot id: Q6INB8
names: Subcellular Location Annotation
messages: Cytoplasm

8355:nono.L
gene id: 8355:nono.L
uniprot id: Q7ZX79
names: Subcellular Location Annotation
messages: Nucleus speckle

8355:edem3.L
gene id: 8355:edem3.L
uniprot id: A0A8J1MTP0
uniprot id: A0A8J1MV30
uniprot id: Q6GQB9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 47 family.
messages: Contains a protease-associated domain (PA) of unknown function.
messages: Endoplasmic reticulum lumen
messages: May be involved in endoplasmic reticulum-associated degradation (ERAD).

8355:LOC121402266
gene id: 8355:LOC121402266
uniprot id: A0A1L8G0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:adrb2.S
gene id: 8355:adrb2.S
uniprot id: Q6PA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fxyd6.S
gene id: 8355:fxyd6.S
uniprot id: Q6DJD6
names: Similarity
messages: Belongs to the FXYD family.

8355:vkorc1l1.S
gene id: 8355:vkorc1l1.S
uniprot id: A0A1L8H880
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:rsad1.L
gene id: 8355:rsad1.L
uniprot id: A0A1L8EU82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Mitochondrion

8355:med15.L
gene id: 8355:med15.L
uniprot id: A0A1L8I0E1
uniprot id: A0A8J0TR04
uniprot id: A0A8J0TZL0
uniprot id: Q6NS15
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway.
messages: Component of the Mediator complex.
messages: Component of the Mediator complex. Interacts with srebf1 and srebf2 (By similarity). Interacts with smad2, smad3 and smad4.
messages: Cytoplasm
messages: Expressed maternally and throughout embryogenesis.
messages: Nucleus

8355:ca7.L
gene id: 8355:ca7.L
uniprot id: A0A1L8GLA2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:hook3.S
gene id: 8355:hook3.S
uniprot id: A0A8J1LNN0
uniprot id: A0A8J1LPP7
uniprot id: A0A8J1LPY1
uniprot id: A0A8J1LR34
uniprot id: Q6GQ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hook family.
messages: Golgi apparatus
messages: Interacts with microtubules.
messages: May function to promote vesicle trafficking and/or fusion. May participate in defining the architecture and localization of the Golgi complex. May act as adapter protein linking the dynein motor complex to various cargos.
messages: cytoskeleton

8355:LOC121398937
gene id: 8355:LOC121398937
uniprot id: A0A8J1LZL5
names: Similarity
messages: Belongs to the cyclin family.

8355:unc5a.S
gene id: 8355:unc5a.S
uniprot id: A0A8J0UV49
uniprot id: A0A8J1MS73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

8355:ist1.S
gene id: 8355:ist1.S
uniprot id: A0A8J1N1D8
uniprot id: Q6DE93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

8355:LOC108695880
gene id: 8355:LOC108695880
uniprot id: A0A8J0SZZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:fam91a1.S
gene id: 8355:fam91a1.S
uniprot id: A0A1L8FTS8
uniprot id: A0A8J0T576
uniprot id: A0A8J0T8C7
uniprot id: A0A8J1L314
names: Similarity
messages: Belongs to the FAM91 family.

8355:ccn1.S
gene id: 8355:ccn1.S
uniprot id: Q98TX5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:htr3b.L
gene id: 8355:htr3b.L
uniprot id: A0A8J0TBC4
names: Subcellular Location Annotation
messages: Membrane

8355:pfkfb3.S
gene id: 8355:pfkfb3.S
uniprot id: A0A1L8GTR7
uniprot id: A0A8J0UW55
uniprot id: A0A8J0UX55
uniprot id: A0A8J1MTQ0
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

8355:thap1.S
gene id: 8355:thap1.S
uniprot id: A0A8J0U2N4
uniprot id: Q6DDT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

8355:LOC121398934
gene id: 8355:LOC121398934
uniprot id: A0A8J1LYA4
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC108717423
gene id: 8355:LOC108717423
uniprot id: A0A8J1KT77
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:LOC108716045
gene id: 8355:LOC108716045
uniprot id: A0A1L8I0M1
uniprot id: A0A8J1L1S5
names: Similarity
messages: Belongs to the THADA family.

8355:myoz2.L
gene id: 8355:myoz2.L
uniprot id: Q63ZK4
names: Similarity
messages: Belongs to the myozenin family.

8355:ncln.S
gene id: 8355:ncln.S
uniprot id: A0A8J1LJA8
uniprot id: Q7ZX90
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

8355:dnaja2.L
gene id: 8355:dnaja2.L
uniprot id: Q7ZWL4
names: Subcellular Location Annotation
messages: Membrane

8355:itga5.L
gene id: 8355:itga5.L
uniprot id: Q06274
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin alpha chain family.
messages: Cell surface
messages: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1.
messages: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity).
messages: Membrane
messages: focal adhesion

8355:ndc80.S
gene id: 8355:ndc80.S
uniprot id: Q8AWF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12514103, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules (By similarity).
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which is composed of ndc80, cdca1, spbc24 and spbc25. The NDC80 complex interacts with mis12 and zwint. Interacts with cep57r.
messages: Nucleus
messages: kinetochore

8355:fibcd1.S
gene id: 8355:fibcd1.S
uniprot id: Q5XK91
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl group-binding receptor which shows a calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids.
messages: Homotetramer; disulfide-linked.
messages: Membrane

8355:vps26c.L
gene id: 8355:vps26c.L
uniprot id: Q4FZN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. Retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN).
messages: Belongs to the VPS26 family.
messages: Component of the heterotrimeric retromer cargo-selective complex (CSC) which is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants.
messages: Cytoplasm
messages: Membrane

8355:thyn1.L
gene id: 8355:thyn1.L
uniprot id: A0A1L8FL07
uniprot id: A0A8J0TAF6
names: Function
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

8355:LOC108697669
gene id: 8355:LOC108697669
uniprot id: A0A1L8FGC5
uniprot id: A0A8J0T6W2
uniprot id: A0A8J1LCW5
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

8355:LOC121402054
gene id: 8355:LOC121402054
uniprot id: A0A8J1MQQ7
names: Subcellular Location Annotation
messages: Membrane

8355:med23.L
gene id: 8355:med23.L
uniprot id: A0A8J0V4V5
uniprot id: Q6P423
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 23 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8355:h2az1.L
gene id: 8355:h2az1.L
uniprot id: P70094
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Expression is highest at the gastrula stage. Expressed preferentially in tissues of mesoderm origin, such as the notochord and some regions of the primitive ear.
messages: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Zl forms a heterodimer with H2B (By similarity).
messages: Ubiquitously expressed.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be required at gastrulation for correct mesoderm formation.

8355:krt12.5.L
gene id: 8355:krt12.5.L
uniprot id: A0A1L8ERR8
names: Similarity
messages: Belongs to the intermediate filament family.

8355:stx3.L
gene id: 8355:stx3.L
uniprot id: A0A310U8E8
uniprot id: A0A8J0U6V1
uniprot id: A0A8J1L4G0
uniprot id: A0A8J1L4H7
uniprot id: A0A8J1L4I2
uniprot id: A0A8J1L657
uniprot id: Q6GLJ9
names: Similarity
messages: Belongs to the syntaxin family.

8355:olfm2.S
gene id: 8355:olfm2.S
uniprot id: A0A1L8GVP2
uniprot id: A0A1L8GVQ9
uniprot id: A0A8J1MSP2
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

8355:tsn.L
gene id: 8355:tsn.L
uniprot id: Q7ZXK0
uniprot id: Q9IAM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

8355:LOC108700447
gene id: 8355:LOC108700447
uniprot id: A0A8J0TQX4
uniprot id: A0A8J1LPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8355:sbk1l.L
gene id: 8355:sbk1l.L
uniprot id: Q91758
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

8355:sh3pxd2b.S
gene id: 8355:sh3pxd2b.S
uniprot id: A0A1L8GV95
uniprot id: A0A8J0URW0
uniprot id: A0A8J0V1U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm
messages: podosome

8355:LOC108712397
gene id: 8355:LOC108712397
uniprot id: A0A8J1MS90
uniprot id: A0A8J1MTG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

8355:suclg1.S
gene id: 8355:suclg1.S
uniprot id: A0A1L8HKM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

8355:serinc2.S
gene id: 8355:serinc2.S
uniprot id: A0A1L8H7H1
uniprot id: A0A8J0UJ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

8355:tuba1cl.3.L
gene id: 8355:tuba1cl.3.L
uniprot id: Q7ZYU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8355:sigmar1.L
gene id: 8355:sigmar1.L
uniprot id: Q6DCU6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Homotrimer (By similarity).
messages: May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile.
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.

8355:LOC108708559
gene id: 8355:LOC108708559
uniprot id: A0A1L8HHS5
uniprot id: A0A8J1M9Z2
names: Similarity
messages: Belongs to the S-100 family.

8355:galnt17.S
gene id: 8355:galnt17.S
uniprot id: A0A1L8H893
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:ep300.L
gene id: 8355:ep300.L
uniprot id: A0A1L8GNI9
uniprot id: A0A8J0V225
uniprot id: A0A8J0V2V6
uniprot id: A0A8J0V395
uniprot id: A0A8J0V765
names: Subcellular Location Annotation
messages: Cytoplasm

8355:ap3d1.S
gene id: 8355:ap3d1.S
uniprot id: A0A1L8HNG4
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

8355:elp1.S
gene id: 8355:elp1.S
uniprot id: Q2TAQ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity).
messages: Cytoplasm
messages: Homodimer. Component of the elongator complex.
messages: Nucleus
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

8355:snx6.S
gene id: 8355:snx6.S
uniprot id: A0A1L8EZK5
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

8355:LOC108696337
gene id: 8355:LOC108696337
uniprot id: A0A8J1L671
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

8355:slit1.S
gene id: 8355:slit1.S
uniprot id: Q7ZXI2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:v2rb-1.L
gene id: 8355:v2rb-1.L
uniprot id: A0A8J1LK43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:chd8.S
gene id: 8355:chd8.S
uniprot id: A0A1L8HPM8
uniprot id: A0A8J0U9Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.
messages: Component of some MLL1/MLL complex.
messages: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. May also act as a transcription activator by participating in efficient U6 RNA polymerase III transcription.
messages: Nucleus

8355:LOC108702811
gene id: 8355:LOC108702811
uniprot id: A0A8J1KI20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:f2rl2.S
gene id: 8355:f2rl2.S
uniprot id: A0A1L8HRG3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC121394541
gene id: 8355:LOC121394541
uniprot id: A0A8J1KYP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

8355:carmil1.L
gene id: 8355:carmil1.L
uniprot id: A0A1L8FY78
uniprot id: A0A8J0VKX6
uniprot id: A0A8J1KY86
uniprot id: A0A8J1KY89
uniprot id: A0A8J1KY90
uniprot id: A0A8J1KZV1
uniprot id: A0A8J1L146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

8355:tmtc4.L
gene id: 8355:tmtc4.L
uniprot id: A0A1L8HH43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

8355:cpne1.S
gene id: 8355:cpne1.S
uniprot id: Q6INK1
names: Similarity
messages: Belongs to the copine family.

8355:hrh4.f8.L
gene id: 8355:hrh4.f8.L
uniprot id: A0A1L8FYS6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:mat2a.S
gene id: 8355:mat2a.S
uniprot id: A0A1L8GRZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

8355:abhd12.L
gene id: 8355:abhd12.L
uniprot id: A0A8J0VA24
uniprot id: A0A8J0VAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC121396460
gene id: 8355:LOC121396460
uniprot id: A0A8J1LF57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

8355:ggt5.L
gene id: 8355:ggt5.L
uniprot id: A0A1L8I0B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

8355:LOC108699103
gene id: 8355:LOC108699103
uniprot id: A0A1L8FC36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121399248
gene id: 8355:LOC121399248
uniprot id: A0A8J1M0L1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108703833
gene id: 8355:LOC108703833
uniprot id: P62799
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8355:LOC108706464
gene id: 8355:LOC108706464
uniprot id: A0A8J0UA86
names: Subcellular Location Annotation
messages: Nucleus

8355:aldh6a1.S
gene id: 8355:aldh6a1.S
uniprot id: A0A1L8F0L7
uniprot id: A0A8J0TM88
uniprot id: A0A8J1LMS1
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

8355:cep70.L
gene id: 8355:cep70.L
uniprot id: Q5HZ81
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

8355:LOC108719638
gene id: 8355:LOC108719638
uniprot id: A0A8J1L3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8355:gtpbp1.S
gene id: 8355:gtpbp1.S
uniprot id: Q5XGS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.
messages: Cytoplasm
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).

8355:LOC108719187
gene id: 8355:LOC108719187
uniprot id: A0A1L8FYF6
uniprot id: A0A8J0VHB8
uniprot id: A0A8J0VJY1
uniprot id: A0A8J0VKZ8
uniprot id: A0A8J0VP51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

8355:nxpe3l.3.S
gene id: 8355:nxpe3l.3.S
uniprot id: A0A8J1L6H3
names: Similarity
messages: Belongs to the NXPE family.

8355:hjv.S
gene id: 8355:hjv.S
uniprot id: A0A1L8F4J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8355:chrnb4.L
gene id: 8355:chrnb4.L
uniprot id: A0A8J1MLC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:pfkfb4.S
gene id: 8355:pfkfb4.S
uniprot id: A0A8J1MZA7
uniprot id: A0A8J1MZJ7
uniprot id: A0A8J1N173
uniprot id: A0A8J1N178
uniprot id: Q6NRY0
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

8355:appl1.S
gene id: 8355:appl1.S
uniprot id: A0A8J0U508
uniprot id: A0A8J0U7T1
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

8355:rtf2.S
gene id: 8355:rtf2.S
uniprot id: A0A1L8ELJ9
uniprot id: Q7SYZ1
names: Similarity
messages: Belongs to the rtf2 family.

8355:LOC121393966
gene id: 8355:LOC121393966
uniprot id: A0A8J1KR28
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:npl.L
gene id: 8355:npl.L
uniprot id: A0A8J0UYL4
uniprot id: A0A8J1MV97
uniprot id: Q3B8E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Belongs to the DapA family. NanA subfamily.
messages: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity).
messages: Cytoplasm
messages: Homotetramer.

8355:eif3b.L
gene id: 8355:eif3b.L
uniprot id: Q569Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Stress granule

8355:prf1.L
gene id: 8355:prf1.L
uniprot id: A0A8J1LPZ5
uniprot id: Q32N46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8355:znf207.S
gene id: 8355:znf207.S
uniprot id: Q7ZXV8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts (via GLEBS region) with bub3.
messages: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. Znf207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks.
messages: Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions.
messages: Nucleus
messages: The GLEBS region mediates interaction with bub3.
messages: The microtubule-binding region is required for efficient loading of bub3 onto kinetochores and proper mitosis.
messages: kinetochore
messages: spindle

8355:lrrc8d.S
gene id: 8355:lrrc8d.S
uniprot id: A0A1L8GG98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8355:nr3c1.S
gene id: 8355:nr3c1.S
uniprot id: A0A1L8GV81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

8355:brinp1.S
gene id: 8355:brinp1.S
uniprot id: A0A1L8F247
names: Similarity
messages: Belongs to the BRINP family.

8355:plxnc1.L
gene id: 8355:plxnc1.L
uniprot id: A0A1L8GYE3
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC447781
gene id: 8355:LOC447781
uniprot id: A0A1L8F431
uniprot id: A0A1L8F445
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

8355:en1.S
gene id: 8355:en1.S
uniprot id: A0A1L8ENE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

8355:opn7b.L
gene id: 8355:opn7b.L
uniprot id: A0A1L8ESN5
names: Subcellular Location Annotation
messages: Membrane

8355:cnot6l.L
gene id: 8355:cnot6l.L
uniprot id: A0A8J0UDU2
uniprot id: Q6IR85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCR4/nocturin family.
messages: Binds 2 magnesium ions, but the ions interact each with only 1 or 2 residues.
messages: Component of the CCR4-NOT complex.
messages: Cytoplasm
messages: Nucleus
messages: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity).

8355:LOC121402020
gene id: 8355:LOC121402020
uniprot id: A0A8J1MPF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:prdm4.L
gene id: 8355:prdm4.L
uniprot id: A0A8J1MGN7
uniprot id: A0A8J1MHL8
uniprot id: A0A8J1MIJ2
uniprot id: Q32N18
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

8355:XB22061511.L
gene id: 8355:XB22061511.L
uniprot id: A0A1L8H329
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:antxr1.S
gene id: 8355:antxr1.S
uniprot id: A0A1L8GS41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

8355:rpl3l.L
gene id: 8355:rpl3l.L
uniprot id: Q640D7
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

8355:adam10.S
gene id: 8355:adam10.S
uniprot id: Q8JIY1
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
messages: Expressed maternally throughout the embryo and then becomes restricted to a pan-neural expression pattern.
messages: Membrane
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: The precursor is cleaved by furin and PCSK7.
messages: The propeptide keeps the metalloprotease in a latent form via a cysteine switch mechanism. This mechanism may be mediated by a highly conserved cysteine (Cys-172) in the propeptide, which interacts and neutralizes the zinc-coordinating HEXGHXXGXXHD catalytic core of the metalloprotease domain. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

8355:neurl2.L
gene id: 8355:neurl2.L
uniprot id: A0A1L8EU18
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108704998
gene id: 8355:LOC108704998
uniprot id: A0A8J1M4M9
uniprot id: A0A8J1M4N2
uniprot id: A0A8J1M5Q9
uniprot id: A0A8J1M6G1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108709237
gene id: 8355:LOC108709237
uniprot id: A0A1L8H5B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

8355:sema4b.S
gene id: 8355:sema4b.S
uniprot id: A0A1L8GSP2
uniprot id: Q6DCP0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:slc7a3.L
gene id: 8355:slc7a3.L
uniprot id: A0A1L8F708
uniprot id: Q8AVC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

8355:LOC121400744
gene id: 8355:LOC121400744
uniprot id: A0A8J1MFZ3
names: Subcellular Location Annotation
messages: Nucleus

8355:serbp1.S
gene id: 8355:serbp1.S
uniprot id: A0A8J0V466
uniprot id: Q7ZWZ2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:spcs3.L
gene id: 8355:spcs3.L
uniprot id: Q6IP12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane

8355:spdef.S
gene id: 8355:spdef.S
uniprot id: A0A1L8H6T5
uniprot id: A0A8J0UC22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:LOC108704331
gene id: 8355:LOC108704331
uniprot id: A0A8J0TWJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

8355:LOC121396917
gene id: 8355:LOC121396917
uniprot id: A0A8J1LG23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

8355:cdc5l.L
gene id: 8355:cdc5l.L
uniprot id: A1A5J6
names: Similarity
messages: Belongs to the CEF1 family.

8355:sox17a.L
gene id: 8355:sox17a.L
uniprot id: Q3KQ35
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed zygotically from late blastula stage. Expressed at all subsequent stages from 10 (early gastrula) to 35 (early tadpole).
messages: In early gastrulae, expressed in the vegetal but not animal hemisphere. The vegetal region is fated to become endoderm, and endodermal expression continues throughout gastrulation and neurulation. At tailbud stages, expression is down-regulated and becomes restricted to the most posterior endoderm and the future liver/gall bladder region. By 3-7 days, endodermal expression is restricted to the gall bladder bud. Also expressed in the embryonic gut, with strong expression in the posterior gut during tailbud stages, but by stage 40, expression rises again in the anterior gut. Expressed at a low level in the adult kidney and spleen.
messages: Interacts (via C-terminus) with ctnnb1/beta-catenin (via Armadillo repeats); this interaction is required for inhibition of wnt-signaling.
messages: Involved in multiple regulatory feedback loops with other endodermal factors, including the nodal-related factors/Xnrs. Autoinduces. Induced by activin. Induced directly by vegt; originally this is in a cell-autonomous fashion but subsequently cell contact is required for expression to be maintained.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activator. Binds to the DNA sequence 5'-AACAAT-3' (By similarity). All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling.

8355:myoz1.S
gene id: 8355:myoz1.S
uniprot id: A0A8J0T4F7
uniprot id: Q7ZYN8
names: Similarity
messages: Belongs to the myozenin family.

8355:ropn1l.L
gene id: 8355:ropn1l.L
uniprot id: Q4V7T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ropporin family.
messages: Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.
messages: cilium
messages: flagellum

8355:ogfr.S
gene id: 8355:ogfr.S
uniprot id: A0A8J0TYA6
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

8355:limk1.L
gene id: 8355:limk1.L
uniprot id: A0A8J1M552
uniprot id: D7PC80
uniprot id: O42565
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Expressed in the early cleavage stages of the embryo. Expression decreases at the gastrula stage and subsequently reappears at the neurula stage, and continues to increase from this point on. In post neurula stages, expressed predominantly in the anterior region of the embryo, including the developing brain and sensory organs.
messages: Nucleus
messages: Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton.
messages: cytoskeleton

8355:hes7.1.S
gene id: 8355:hes7.1.S
uniprot id: A0A8J0U3B7
names: Subunit
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

8355:smad4.2.S
gene id: 8355:smad4.2.S
uniprot id: A0A8J0TI45
uniprot id: A0A8J0TPS5
uniprot id: A0A8J0TRV0
uniprot id: A0A8J0TSX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8355:LOC108703501
gene id: 8355:LOC108703501
uniprot id: A0A8J1MV14
names: Subcellular Location Annotation
messages: Secreted

8355:topbp1.L
gene id: 8355:topbp1.L
uniprot id: Q800K6
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Has dual roles in initiation of DNA replication, and regulation of checkpoint responses. Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages. Necessary for the loading of replication factors onto chromatin, including gemc1, cdc45, DNA polymerases and components of the GINS complex such as ginsl/sld5. Binds chromatin in both S-phase cyclin-dependent kinase (S-CDK)-independent and S-CDK-dependent modes. Chromatin binding is required for the action of S-CDK, which in turn triggers the formation of preinitiation complexes of DNA replication. Its role in checkpoint activation is independent of the DNA replication role. In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the chek1 signaling pathway and block S-phase progression. Increases the kinase activity of atr to numerous substrates, and is required for the phosphorylation of Rad1.
messages: Interacts with cdc45. Interacts (via BRCT domains) with ticrr; interaction is cdk2-dependent. Interacts with atr in the presence of atrip. Interacts with recql4 (via N-terminus).
messages: Nucleus
messages: Phosphorylation at 1131 is essential for phosphorylation of chek1, and thus for checkpoint regulation.
messages: The N-terminal half is sufficient for DNA replication.
messages: centrosome
messages: spindle pole

8355:LOC108713037
gene id: 8355:LOC108713037
uniprot id: A0A8J0UQS7
uniprot id: A0A8J1MRJ9
uniprot id: A0A8J1MSQ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:LOC108711293
gene id: 8355:LOC108711293
uniprot id: A0A8J1MLJ5
uniprot id: A0A8J1MMC1
uniprot id: A0A8J1MMF9
uniprot id: A0A8J1MNI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Membrane
messages: Synapse
messages: growth cone

8355:LOC108714906
gene id: 8355:LOC108714906
uniprot id: A0A8J0V5D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121393855
gene id: 8355:LOC121393855
uniprot id: A0A8J1KTH7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:kcne5.L
gene id: 8355:kcne5.L
uniprot id: Q8AWZ7
names: Similarity
messages: Belongs to the potassium channel KCNE family.

8355:scamp2.S
gene id: 8355:scamp2.S
uniprot id: A0A1L8GT80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

8355:c4bpa.L
gene id: 8355:c4bpa.L
uniprot id: A0A1L8HEV0
uniprot id: A0A8J0UEZ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:copb1.L
gene id: 8355:copb1.L
uniprot id: A0A1L8GIC5
uniprot id: Q6GNR5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:LOC108708589
gene id: 8355:LOC108708589
uniprot id: A0A8J0UGS0
uniprot id: A0A8J1M9U3
uniprot id: A0A8J1M9U4
uniprot id: A0A8J1MA39
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:cyp51a1.S
gene id: 8355:cyp51a1.S
uniprot id: Q66IT2
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:tmtc3.L
gene id: 8355:tmtc3.L
uniprot id: A0A1L8GY93
uniprot id: A0A8J0UID1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

8355:LOC108698051
gene id: 8355:LOC108698051
uniprot id: A0A8J0TGL6
uniprot id: A0A8J1MQR9
uniprot id: A0A8J1MQS8
uniprot id: A0A8J1MQU1
uniprot id: A0A8J1MQV5
uniprot id: A0A8J1MQW5
uniprot id: A0A8J1MQW8
uniprot id: A0A8J1MQZ8
uniprot id: A0A8J1MR03
uniprot id: A0A8J1MR11
uniprot id: A0A8J1MRR3
uniprot id: A0A8J1MRR7
uniprot id: A0A8J1MS10
uniprot id: A0A8J1MS35
uniprot id: A0A8J1MT12
uniprot id: A0A8J1MT22
uniprot id: A0A8J1MT32
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:samm50.S
gene id: 8355:samm50.S
uniprot id: Q6PA35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Belongs to the SAM50/omp85 family.
messages: Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure.
messages: May play a role in the maintenance of the structure of mitochondrial cristae.
messages: Mitochondrion outer membrane

8355:ddx58.L
gene id: 8355:ddx58.L
uniprot id: A0A1L8HXR0
uniprot id: A0A8J0UYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

8355:med31.S
gene id: 8355:med31.S
uniprot id: Q6GQA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8355:hsp30d.L
gene id: 8355:hsp30d.L
uniprot id: P30219
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:cdr2l.S
gene id: 8355:cdr2l.S
uniprot id: A0A1L8EMW1
names: Similarity
messages: Belongs to the CDR2 family.

8355:ptp4a1.L
gene id: 8355:ptp4a1.L
uniprot id: Q6AZN3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

8355:cnksr1.L
gene id: 8355:cnksr1.L
uniprot id: A0A1L8HED5
uniprot id: A0A8J1M847
uniprot id: A0A8J1M9Y8
names: Similarity
messages: Belongs to the CNKSR family.

8355:chst8.S
gene id: 8355:chst8.S
uniprot id: A0A8J0U4L2
uniprot id: A0A8J0U6M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:shank2.L
gene id: 8355:shank2.L
uniprot id: A0A8J1MU33
uniprot id: A0A8J1MU42
uniprot id: A0A8J1MU47
uniprot id: A0A8J1MU52
uniprot id: A0A8J1MUB9
uniprot id: A0A8J1MUD0
uniprot id: A0A8J1MV76
uniprot id: A0A8J1MV81
uniprot id: A0A8J1MV87
uniprot id: A0A8J1MVJ5
uniprot id: A0A8J1MVK1
uniprot id: A0A8J1MVK8
uniprot id: A0A8J1MWH1
uniprot id: A0A8J1MWH7
uniprot id: A0A8J1MWI4
uniprot id: Q52KW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHANK family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction (By similarity).
messages: Synapse

8355:npy4r.L
gene id: 8355:npy4r.L
uniprot id: A0A1L8H1K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:csnk2a1.S
gene id: 8355:csnk2a1.S
uniprot id: A0A1L8EM01
uniprot id: A0A8J0TQC4
uniprot id: A0A8J0TXQ7
uniprot id: Q6INV5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:hadh.L
gene id: 8355:hadh.L
uniprot id: Q7T0N8
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

8355:cnnm3.L
gene id: 8355:cnnm3.L
uniprot id: A0A8J1MIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

8355:cnpy1.L
gene id: 8355:cnpy1.L
uniprot id: A0A1L8FV61
names: Similarity
messages: Belongs to the canopy family.

8355:stpg1.L
gene id: 8355:stpg1.L
uniprot id: Q3KQ80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STPG1 family.
messages: Cytoplasm
messages: May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.
messages: Nucleus

8355:XB5765667.L
gene id: 8355:XB5765667.L
uniprot id: A0A1L8GNX4
uniprot id: A0A8J0UY34
uniprot id: A0A8J0V3I9
uniprot id: A0A8J0V7G0
uniprot id: A0A8J1MXZ6
uniprot id: A0A8J1MZH5
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

8355:epha7.L
gene id: 8355:epha7.L
uniprot id: A0A1L8G975
uniprot id: A0A8J0VB44
uniprot id: A0A8J0VCE8
uniprot id: A0A8J0VGQ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:mttp.1.L
gene id: 8355:mttp.1.L
uniprot id: A0A1L8HV08
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:dmap1.L
gene id: 8355:dmap1.L
uniprot id: Q641D1
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108713552
gene id: 8355:LOC108713552
uniprot id: A0A8J0V3R1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108705664
gene id: 8355:LOC108705664
uniprot id: A0A8J1L610
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

8355:rpa2.L
gene id: 8355:rpa2.L
uniprot id: Q6IP18
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 2 family.
messages: Component of the replication protein A complex (RPA/RP-A), a heterotrimeric complex composed of RPA1, RPA2 and RPA3.
messages: Differentially phosphorylated throughout the cell cycle, becoming phosphorylated at the G1-S transition and dephosphorylated in late mitosis. Phosphorylation increases upon replication fork stalling.
messages: Nucleus
messages: PML body

8355:ablim1.S
gene id: 8355:ablim1.S
uniprot id: A0A8J1L9K9
uniprot id: A0A8J1L9L0
uniprot id: A0A8J1L9L4
uniprot id: A0A8J1L9L6
uniprot id: A0A8J1L9L9
uniprot id: A0A8J1L9M1
uniprot id: A0A8J1L9M5
uniprot id: A0A8J1L9M6
uniprot id: A0A8J1L9P7
uniprot id: A0A8J1L9Q2
uniprot id: A0A8J1L9Q7
uniprot id: A0A8J1LB59
uniprot id: A0A8J1LB64
uniprot id: A0A8J1LB70
uniprot id: A0A8J1LC35
uniprot id: A0A8J1LC41
uniprot id: A0A8J1LC46
uniprot id: A0A8J1LC50
uniprot id: B1H1T4
names: Subcellular Location Annotation
messages: Cytoplasm

8355:klhl20.L
gene id: 8355:klhl20.L
uniprot id: Q6DFF6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of cul3, klhl20 and rbx1.
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity).
messages: perinuclear region

8355:pah.S
gene id: 8355:pah.S
uniprot id: A0A1L8GUW1
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

8355:tm2d2.S
gene id: 8355:tm2d2.S
uniprot id: A0A1L8GRP5
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108716348
gene id: 8355:LOC108716348
uniprot id: A0A1L8GA26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

8355:entpd4.L
gene id: 8355:entpd4.L
uniprot id: Q5U4W0
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

8355:ndufaf2.L
gene id: 8355:ndufaf2.L
uniprot id: Q5U569
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

8355:rab3gap1.S
gene id: 8355:rab3gap1.S
uniprot id: A0A1L8ENU5
uniprot id: A0A8J1LZ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

8355:lars1.L
gene id: 8355:lars1.L
uniprot id: Q6AX83
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8355:LOC108707602
gene id: 8355:LOC108707602
uniprot id: A0A8J1M7F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108712940
gene id: 8355:LOC108712940
uniprot id: A0A1L8HWR0
uniprot id: A0A8J0UWW7
uniprot id: A0A8J1KL60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:mrpl35.L
gene id: 8355:mrpl35.L
uniprot id: A0A1L8HT02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

8355:LOC108709892
gene id: 8355:LOC108709892
uniprot id: A0A1L8HA31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:ppih.L
gene id: 8355:ppih.L
uniprot id: A0A1L8FMC3
uniprot id: Q4QQZ3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8355:ino80.L
gene id: 8355:ino80.L
uniprot id: A0A1L8FB65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

8355:chmp2b.S
gene id: 8355:chmp2b.S
uniprot id: A0A8J0UHW9
uniprot id: Q7SYR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).
messages: cytosol

8355:snrpa1.S
gene id: 8355:snrpa1.S
uniprot id: Q641E8
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

8355:LOC121396911
gene id: 8355:LOC121396911
uniprot id: A0A8J1LHE6
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121396419
gene id: 8355:LOC121396419
uniprot id: A0A1L8FFN1
uniprot id: A0A8J1LCN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:ifitm1.S
gene id: 8355:ifitm1.S
uniprot id: A0A8J0V4M6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:bckdk.S
gene id: 8355:bckdk.S
uniprot id: Q6IRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

8355:plat.L
gene id: 8355:plat.L
uniprot id: A0A1L8H251
uniprot id: A0A8J0UND0
uniprot id: A0A8J0URA6
uniprot id: Q6P7I9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:foxe3.L
gene id: 8355:foxe3.L
uniprot id: Q9PTK2
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By pax6.
messages: First expressed at the end of gastrulation (stage 13) in the anterior ectodermal placode. During intermediate neural plate stages (stages 14-16), expression expands to the presumptive nasal ectoderm (PNE) and the presumptive lens ectoderm (PLE). By stages 18-21, expression begins to deplete in the PNE, while intensifying in the PLE so that by late neural stages (stages 22), expression is restricted to the PLE. Throughout tailbud stages (stage 23-31), expression is maintained in the lens placode and lens vesicle. In the maturing lens (stage 32-onwards), expression is restricted to the anterior lens epithelium, where it remains during the tadpole stage. In tadpoles there is additional expression in the ventral midline of the pharynx. Expression continues in the adult eye.
messages: Nucleus
messages: Probable transcription factor. Mediates lens formation in the embryo by promoting the proliferation of the specified lens ectoderm and suppressing its terminal differentiation.

8355:LOC121394221
gene id: 8355:LOC121394221
uniprot id: A0A8J1KW79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:dok6.L
gene id: 8355:dok6.L
uniprot id: A0A1L8FYE6
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

8355:thrsp.S
gene id: 8355:thrsp.S
uniprot id: A0A1L8F2V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

8355:tgfb1.L
gene id: 8355:tgfb1.L
uniprot id: P16176
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide: Interacts with Transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains (TGF-beta-1) in a latent state; each Latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Transforming growth factor beta-1: Homodimer; disulfide-linked. Transforming growth factor beta-1: Interacts with TGF-beta receptors (tgfbr1 and tgfbr2), leading to signal transduction.
messages: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.
messages: Secreted
messages: The 'straitjacket' and 'arm' domains encircle the Transforming growth factor beta-1 (TGF-beta-1) monomers and are fastened together by strong bonding between Lys-53 and Tyr-99/Tyr-100.
messages: The cell attachment site motif mediates binding to integrins (ITGAV:ITGB6 or ITGAV:ITGB8). The motif locates to a long loop in the arm domain called the bowtie tail. Integrin-binding stabilizes an alternative conformation of the bowtie tail. Activation by integrin requires force application by the actin cytoskeleton, which is resisted by the 'milieu molecules' (such as ltbp1, lrrc32/garp and/or lrrc33/nrros), resulting in distortion of the prodomain and release of the active TGF-beta-1.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
messages: Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as ltbp1, lrrc32/garp and lrrc33/nrros that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (tgfbr1 and tgfbr2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (By similarity). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).
messages: extracellular matrix

8355:mtap.L
gene id: 8355:mtap.L
uniprot id: A0A1L8HXY5
uniprot id: A0A8J0ULS2
uniprot id: A0A8J1MBR1
uniprot id: A0A8J1MCD5
uniprot id: Q52KZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:sesn1.S
gene id: 8355:sesn1.S
uniprot id: A0A1L8G2X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

8355:lhx1.S
gene id: 8355:lhx1.S
uniprot id: A0A1L8H779
uniprot id: A0A8J0UKB0
uniprot id: A0A8J0UKD8
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121398041
gene id: 8355:LOC121398041
uniprot id: A0A8J1LSD4
uniprot id: A0A8J1LSF6
uniprot id: A0A8J1LT36
uniprot id: A0A8J1LTU6
names: Similarity
messages: Belongs to the mesothelin family.

8355:cul2.L
gene id: 8355:cul2.L
uniprot id: A0A8J0VH09
uniprot id: Q6PCF2
names: Similarity
messages: Belongs to the cullin family.

8355:tmem147.S
gene id: 8355:tmem147.S
uniprot id: Q6DFI2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of the ribosome-associated endoplasmic reticulum translocon complex.
messages: Endoplasmic reticulum membrane
messages: Necessary for the translocation in the endoplasmic reticulum and the biogenesis of multi-pass membrane proteins.

8355:tgm3l.3.L
gene id: 8355:tgm3l.3.L
uniprot id: A0A1L8ETY7
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

8355:cd3g.S
gene id: 8355:cd3g.S
uniprot id: P79951
names: Subcellular Location Annotation
messages: Membrane

8355:XB5835883.L
gene id: 8355:XB5835883.L
uniprot id: A0A1L8FXS7
uniprot id: Q5GA91
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

8355:LOC121397723
gene id: 8355:LOC121397723
uniprot id: A0A8J1LP82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108713890
gene id: 8355:LOC108713890
uniprot id: A0A1L8GJL2
uniprot id: A0A8J0V0J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: lamellipodium

8355:LOC108712725
gene id: 8355:LOC108712725
uniprot id: A0A8J1MRH5
names: Similarity
messages: Belongs to the peptidase C14A family.

8355:gpx7.S
gene id: 8355:gpx7.S
uniprot id: Q5M784
names: Similarity
messages: Belongs to the glutathione peroxidase family.

8355:LOC108700566
gene id: 8355:LOC108700566
uniprot id: A0A8J1LM68
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

8355:ier3ip1.S
gene id: 8355:ier3ip1.S
uniprot id: A0A1L8HS51
uniprot id: A0A8J0UDT2
names: Similarity
messages: Belongs to the YOS1 family.

8355:src.S
gene id: 8355:src.S
uniprot id: A0A8J0TPX0
uniprot id: A0A8J0TX47
uniprot id: A0A8J0U032
uniprot id: Q2TAR1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:LOC108701226
gene id: 8355:LOC108701226
uniprot id: A0A8J0TTW5
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

8355:itgb3.L
gene id: 8355:itgb3.L
uniprot id: A0A8J1LTS7
uniprot id: B7ZQZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

8355:LOC108707733
gene id: 8355:LOC108707733
uniprot id: A0A1L8HH83
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108713590
gene id: 8355:LOC108713590
uniprot id: A0A1L8GQ12
names: Similarity
messages: Belongs to the TAFA family.

8355:foxi1.S
gene id: 8355:foxi1.S
uniprot id: A0A1L8GVF7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108704702
gene id: 8355:LOC108704702
uniprot id: A0A8J1LGA0
uniprot id: A0A8J1LH75
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:hspb8.L
gene id: 8355:hspb8.L
uniprot id: Q7SYX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.

8355:tgif1.L
gene id: 8355:tgif1.L
uniprot id: A0A1L8FYM7
names: Subcellular Location Annotation
messages: Nucleus

8355:mapre2.S
gene id: 8355:mapre2.S
uniprot id: A0A8J1L347
uniprot id: Q7ZXP1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: Cytoplasm
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes.
messages: The N-terminal domain may form a hydrophobic cleft involved in microtubule binding and the C-terminal may be involved in the formation of mutually exclusive complexes with APC and DCTN1.
messages: cytoskeleton

8355:LOC121402058
gene id: 8355:LOC121402058
uniprot id: A0A8J1MPK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121393152
gene id: 8355:LOC121393152
uniprot id: A0A8J1KH58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:slc41a3.L
gene id: 8355:slc41a3.L
uniprot id: A0A1L8GPM6
uniprot id: A0A8J0UY56
uniprot id: Q6GQC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:ndufa10.L
gene id: 8355:ndufa10.L
uniprot id: A0A8J1LSD2
uniprot id: Q5XGR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

8355:LOC108696787
gene id: 8355:LOC108696787
uniprot id: A0A1L8FNQ2
uniprot id: A0A8J0T9Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

8355:LOC108714608
gene id: 8355:LOC108714608
uniprot id: A0A1L8GPB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

8355:slc9a3r2.L
gene id: 8355:slc9a3r2.L
uniprot id: A0A8J1LUV4
names: Subcellular Location Annotation
messages: Endomembrane system

8355:LOC108718009
gene id: 8355:LOC108718009
uniprot id: A0A8J0VCR5
uniprot id: A0A8J0VFI8
uniprot id: A0A8J0VFT2
uniprot id: A0A8J0VFT7
uniprot id: A0A8J0VGS8
uniprot id: A0A8J0VGT4
uniprot id: A0A8J0VL58
uniprot id: A0A8J1KTJ3
uniprot id: A0A8J1KTJ7
uniprot id: A0A8J1KTJ9
uniprot id: A0A8J1KTK2
uniprot id: A0A8J1KTK4
uniprot id: A0A8J1KTK5
uniprot id: A0A8J1KTK8
uniprot id: A0A8J1KTK9
uniprot id: A0A8J1KTL3
uniprot id: A0A8J1KV50
uniprot id: A0A8J1KV56
uniprot id: A0A8J1KV62
uniprot id: A0A8J1KWL0
uniprot id: A0A8J1KWL5
uniprot id: A0A8J1KWM1
names: Subcellular Location Annotation
messages: cytoskeleton

8355:ess2.S
gene id: 8355:ess2.S
uniprot id: A0A8J1LNF8
uniprot id: Q6GR02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

8355:dsc3.L
gene id: 8355:dsc3.L
uniprot id: A0A1L8FYV3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

8355:msra.2.L
gene id: 8355:msra.2.L
uniprot id: A0A1L8HE87
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

8355:LOC108707036
gene id: 8355:LOC108707036
uniprot id: A0A8J1M510
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

8355:ubqln1.L
gene id: 8355:ubqln1.L
uniprot id: Q6DCM1
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

8355:cog3.S
gene id: 8355:cog3.S
uniprot id: A0A1L8H9H2
uniprot id: A0A8J0ULH2
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

8355:akr1a1.L
gene id: 8355:akr1a1.L
uniprot id: A0A1L8GM75
uniprot id: A0A8J0UZ56
uniprot id: A0A8J0V334
uniprot id: Q6GMC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Displays no reductase activity towards retinoids (By similarity).
messages: Cell membrane
messages: Membrane
messages: cytosol

8355:vbp1.S
gene id: 8355:vbp1.S
uniprot id: A0A1L8F2P2
uniprot id: A9UM29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

8355:LOC108703520
gene id: 8355:LOC108703520
uniprot id: A0A1B4ZDM2
names: Subcellular Location Annotation
messages: Nucleus

8355:mgat1.S
gene id: 8355:mgat1.S
uniprot id: Q90W56
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

8355:LOC108710191
gene id: 8355:LOC108710191
uniprot id: A0A8J1MJQ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

8355:mfsd14b.S
gene id: 8355:mfsd14b.S
uniprot id: Q641I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8355:LOC121398794
gene id: 8355:LOC121398794
uniprot id: A0A8J1LXC9
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:uba1.L
gene id: 8355:uba1.L
uniprot id: A0A8J0T8E8
uniprot id: Q6P285
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

8355:krt12.2.S
gene id: 8355:krt12.2.S
uniprot id: Q6DDD5
names: Similarity
messages: Belongs to the intermediate filament family.

8355:LOC108716633
gene id: 8355:LOC108716633
uniprot id: A0A1L8G7J8
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:snrpb.S
gene id: 8355:snrpb.S
uniprot id: Q0IHK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

8355:dnase1l1.S
gene id: 8355:dnase1l1.S
uniprot id: A0A1L8EZN6
uniprot id: A1L2J6
names: Similarity
messages: Belongs to the DNase I family.

8355:spopl.L
gene id: 8355:spopl.L
uniprot id: A0A8J0TR43
uniprot id: Q6GR09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tdpoz family.
messages: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency.
messages: Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL (By similarity).
messages: Nucleus

8355:LOC108709205
gene id: 8355:LOC108709205
uniprot id: A0A8J0UJB6
uniprot id: A0A8J1MCN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

8355:LOC108700639
gene id: 8355:LOC108700639
uniprot id: A0A1L8F0T8
uniprot id: A0A8J1LQK8
names: Similarity
messages: Belongs to the glutamine synthetase family.

8355:rbbp4.S
gene id: 8355:rbbp4.S
uniprot id: A0A310U4Z0
uniprot id: Q6INH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Component of the DREAM complex (By similarity). Binds directly to histone H4, probably via helix 1 of the histone fold, a region that is not accessible when histone H4 is in chromatin (By similarity). Probably forms a large corepressor complex that contains ncor1, sin3a, hdac1-A and/or hdac1-B, hdac2, rbbp4-A and/or rbbp4-B and possibly rbbp7 (PubMed:11254656).
messages: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.
messages: Nucleus
messages: telomere

8355:ptafr.S
gene id: 8355:ptafr.S
uniprot id: A0A1L8H7L3
uniprot id: A0A8J0UKH9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

8355:cadm1.S
gene id: 8355:cadm1.S
uniprot id: A0A1L8FFV2
uniprot id: A0A8J0TCG8
uniprot id: A0A8J1LCN9
uniprot id: A0A8J1LCR8
uniprot id: A0A8J1LCX2
uniprot id: A0A8J1LE99
uniprot id: A0A8J1LF71
uniprot id: A0A8J1LF76
names: Similarity
messages: Belongs to the nectin family.

8355:LOC108699578
gene id: 8355:LOC108699578
uniprot id: A0A1L8FC08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:thoc2.S
gene id: 8355:thoc2.S
uniprot id: A0A1L8F2J0
uniprot id: A0A8J1LQ25
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

8355:lct.1.L
gene id: 8355:lct.1.L
uniprot id: A8WH42
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

8355:otp.S
gene id: 8355:otp.S
uniprot id: A0A1L8HRF6
names: Subcellular Location Annotation
messages: Nucleus

8355:pkn3.S
gene id: 8355:pkn3.S
uniprot id: A0A1L8F1D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

8355:psmc5.L
gene id: 8355:psmc5.L
uniprot id: Q6GQB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

8355:anxa2.S
gene id: 8355:anxa2.S
uniprot id: P27006
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
messages: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.
messages: Tetramer of 2 light chains (p10 proteins) and 2 heavy chains (p36 proteins).
messages: basement membrane

8355:nxpe4.L
gene id: 8355:nxpe4.L
uniprot id: A0A8J0TBP1
names: Similarity
messages: Belongs to the NXPE family.

8355:bmp3.L
gene id: 8355:bmp3.L
uniprot id: Q7T2X7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dorsalizing factor. Antagonizes mesoderm formation by ventralizing BMPs.
messages: Homodimer. Can form heterodimers with ADMP, BMP-2-I and/or BMP-2-II, and DERRIERE.
messages: Secreted
messages: Tends to mark the dorsal ectodermal and mesodermal cells. Initially expressed in the embryonic ectoderm and throughout the marginal zone from the late blastula to gastrula stages. Expression is restricted to the chordal and prechordal mesoderm by the neurula stages, and to certain cells of the cephalic neural crest at the tailbud stage.

8355:inpp5k.L
gene id: 8355:inpp5k.L
uniprot id: A0A1L8HDR5
uniprot id: A0A8J0U606
uniprot id: A0A8J0UCY2
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

8355:foxd4l1.2.L
gene id: 8355:foxd4l1.2.L
uniprot id: A0A1L8HY53
uniprot id: A0A8J1ML38
uniprot id: B7ZPB6
uniprot id: Q9PT67
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At the onset of gastrulation, expressed in the superficial layer of cells in the dorsal blastopore lip (Spemann organizer). In the open neural plate, expressed in a row of cells destined to become the floor plate of the neural tube. After neural tube closure, only detected in the tailtip and a small area located at the midbrain/hindbrain boundary.
messages: Belongs to the protein kinase superfamily.
messages: Expressed both maternally and zygotically. Maternal expression levels are low and become further reduced after fertilization. Zygotic expression begins at the mid-blastula transition and peaks during the gastrula/neurula stages. A lower level of expression is then maintained during tailbud and later stages.
messages: Nucleus
messages: Transcriptional repressor.

8355:mthfd1l.L
gene id: 8355:mthfd1l.L
uniprot id: A0A1L8G7L9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

8355:eya3.L
gene id: 8355:eya3.L
uniprot id: Q5EAU1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

8355:LOC108695866
gene id: 8355:LOC108695866
uniprot id: A0A1L8FMP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fzd8.L
gene id: 8355:fzd8.L
uniprot id: A0A8J0VH32
uniprot id: O93274
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: First expressed at high levels in the late blastula stages. At early gastrula, expressed in the deep cells of the Spemann organizer prior to involution of the dorsal blastopore lip. Detected in presumptive neurectoderm as gastrulation proceeds. Becomes restricted to the anterior ectoderm by the end of gastrulation. At neurula stages, localized in the most anterior region of the embryo, mainly in the anterior ectoderm including telencephalic and cement gland regions.
messages: Interacts with lypd6 and the interaction is strongly enhanced by wnt3a (PubMed:23987510).
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Membrane
messages: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8, Wnt5A or Wnt3A induces expression of beta-catenin target genes. Displays an axis-inducing activity.
messages: The FZ domain is involved in binding with Wnt ligands.

8355:fam83c.L
gene id: 8355:fam83c.L
uniprot id: A0A1L8ES39
names: Similarity
messages: Belongs to the FAM83 family.

8355:mpc2.S
gene id: 8355:mpc2.S
uniprot id: A0A8J1MB27
uniprot id: Q7ZY14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

8355:six4.S
gene id: 8355:six4.S
uniprot id: A0A1L8F006
names: Subcellular Location Annotation
messages: Nucleus

8355:il17c.S
gene id: 8355:il17c.S
uniprot id: A0A8J0TW20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8355:degs3.L
gene id: 8355:degs3.L
uniprot id: Q7SYZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:ca12.L
gene id: 8355:ca12.L
uniprot id: A0A8J0ULE0
uniprot id: A1L3H6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:st8sia1.S
gene id: 8355:st8sia1.S
uniprot id: A0A8J0UNF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:stat2.S
gene id: 8355:stat2.S
uniprot id: A0A1L8H9P8
uniprot id: A0A8J1MF37
uniprot id: A0A8J1MF43
uniprot id: A0A8J1MFM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8355:krt70.L
gene id: 8355:krt70.L
uniprot id: A0A8J1LRU2
uniprot id: Q7ZXE6
names: Similarity
messages: Belongs to the intermediate filament family.

8355:irx5.L
gene id: 8355:irx5.L
uniprot id: Q90XW5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephros kidney development. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
messages: Belongs to the TALE/IRO homeobox family.
messages: By hoxb4 and hoxb5. Down-regulated by hoxb9.
messages: Early in gastrulation, expressed in cells beneath the blastopore lip. Subsequently expressed in the neural plate in overlapping patterns with other irx members, which all share an anterior border of expression. At the time of neural tube closure (stage 19) in regions of the midbrain, hindbrain, neural tube and optic vesicle, where expression continues during tailbud stages. In stage 34, expressed throughout the eye retina. Does not appear to be expressed in the developing heart or pronephros.
messages: Nucleus

8355:vdac3.L
gene id: 8355:vdac3.L
uniprot id: A0A8J0UFJ0
uniprot id: A0A8J0UNE0
uniprot id: A0A8J0URE2
uniprot id: Q6GR11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

8355:LOC108716793
gene id: 8355:LOC108716793
uniprot id: A0A1L8G8W7
uniprot id: A0A8J0V7U5
uniprot id: A0A8J1KRN4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:LOC108709070
gene id: 8355:LOC108709070
uniprot id: A0A8J0UHL2
uniprot id: A0A8J1MC12
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108699487
gene id: 8355:LOC108699487
uniprot id: A0A1L8FDJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8355:trpm3.S
gene id: 8355:trpm3.S
uniprot id: A0A8J0U9H2
names: Subcellular Location Annotation
messages: Membrane

8355:npb.L
gene id: 8355:npb.L
uniprot id: A0A8J0TX08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

8355:LOC108715924
gene id: 8355:LOC108715924
uniprot id: A0A8J1KLU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

8355:hoxb9.L
gene id: 8355:hoxb9.L
uniprot id: A0A1L8ES24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8355:zbtb8os.L
gene id: 8355:zbtb8os.L
uniprot id: A0A1L8HFR8
uniprot id: A0A8J0UF79
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

8355:pds5a.S
gene id: 8355:pds5a.S
uniprot id: Q4KLU7
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Chromosomes assembled in the absence of pds5a and aprin/pds5b proteins have a mild defect in centromere cohesion in vitro.
messages: Interacts with the cohesin complex. Binds chromatin in a cohesin-dependent manner.
messages: May regulate sister chromatid cohesion during mitosis and couple it to DNA replication.
messages: Nucleus

8355:naa50.S
gene id: 8355:naa50.S
uniprot id: Q6GP53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GNAT subfamily.
messages: Cytoplasm
messages: N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. The relevance of N-epsilon-acetyltransferase activity is however unclear. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin.
messages: Nucleus

8355:polr1a.L
gene id: 8355:polr1a.L
uniprot id: Q8UVY7
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

8355:ptdss2.L
gene id: 8355:ptdss2.L
uniprot id: B5DE41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:tbx21.L
gene id: 8355:tbx21.L
uniprot id: A0A1L8ES01
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:bri3.L
gene id: 8355:bri3.L
uniprot id: A0A1L8EXX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

8355:agmat.L
gene id: 8355:agmat.L
uniprot id: A0A1L8FPE8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

8355:aqp5.S
gene id: 8355:aqp5.S
uniprot id: A0A1L8HA83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8355:srp68.S
gene id: 8355:srp68.S
uniprot id: A0A1L8EMX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

8355:ca14.L
gene id: 8355:ca14.L
uniprot id: A0A8J1LK62
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:LOC100126651
gene id: 8355:LOC100126651
uniprot id: A8E619
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:LOC108706014
gene id: 8355:LOC108706014
uniprot id: A0A8J1MI57
names: Subcellular Location Annotation
messages: Membrane

8355:npepl1.L
gene id: 8355:npepl1.L
uniprot id: Q05AX8
names: Similarity
messages: Belongs to the peptidase M17 family.

8355:pycr3.S
gene id: 8355:pycr3.S
uniprot id: A0A8J0T5C0
uniprot id: A0A8J1L5G3
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

8355:fam120b.L
gene id: 8355:fam120b.L
uniprot id: A0A8J1KMY0
uniprot id: A0A8J1KPL3
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

8355:apip.L
gene id: 8355:apip.L
uniprot id: A0A1L8GIP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.
messages: Cytoplasm

8355:LOC108700331
gene id: 8355:LOC108700331
uniprot id: A0A1L8F4E3
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:rps2.L
gene id: 8355:rps2.L
uniprot id: Q7T0R9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.

8355:hoxc3.L
gene id: 8355:hoxc3.L
uniprot id: A0A1L8HIF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:adora2a.S
gene id: 8355:adora2a.S
uniprot id: A0A1L8HQB8
uniprot id: Q6GM75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

8355:slc1a3.S
gene id: 8355:slc1a3.S
uniprot id: A0A1L8HRR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

8355:coq5.L
gene id: 8355:coq5.L
uniprot id: Q4V7R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least coq3, coq4, coq5, coq6, coq7 and coq9.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

8355:drd5.L
gene id: 8355:drd5.L
uniprot id: A0A1L8HTH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:camk2a.S
gene id: 8355:camk2a.S
uniprot id: A0A8J0UMF6
uniprot id: A0A8J0UMG2
uniprot id: A0A8J0UT80
uniprot id: A0A8J0UUB0
uniprot id: A0A8J0UUB7
uniprot id: A0A8J0UUE5
uniprot id: A0A8J0UUF1
uniprot id: A0A8J0UXS7
uniprot id: A0A8J1MNY3
uniprot id: A0A8J1MNY7
uniprot id: A0A8J1MP35
uniprot id: A0A8J1MPY8
uniprot id: A0A8J1MPZ4
uniprot id: A0A8J1MQ24
uniprot id: A0A8J1MR29
uniprot id: A0A8J1MR37
uniprot id: Q6GLR3
uniprot id: Q91549
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8355:rars2.S
gene id: 8355:rars2.S
uniprot id: A0A8J0VDM4
uniprot id: Q6GQJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

8355:mapt.S
gene id: 8355:mapt.S
uniprot id: A0A1L8EL67
uniprot id: A0A8J0TX80
uniprot id: A0A8J1LZF4
uniprot id: A0A8J1LZH4
uniprot id: A0A8J1LZL8
uniprot id: A0A8J1M0P6
uniprot id: A0A8J1M1J6
uniprot id: A0A8J1M1K0
names: Subcellular Location Annotation
messages: cytoskeleton

8355:MGC80700
gene id: 8355:MGC80700
uniprot id: Q6GP41
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

8355:grwd1.S
gene id: 8355:grwd1.S
uniprot id: Q6GN22
names: Subcellular Location Annotation
messages: Nucleus

8355:pus10.S
gene id: 8355:pus10.S
uniprot id: Q6ING2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus
messages: Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs.

8355:lmx1b.2.L
gene id: 8355:lmx1b.2.L
uniprot id: A0A8J1MP01
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108705945
gene id: 8355:LOC108705945
uniprot id: A0A8J1M652
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:cyb5a.L
gene id: 8355:cyb5a.L
uniprot id: Q6DE13
names: Similarity
messages: Belongs to the cytochrome b5 family.

8355:LOC121394173
gene id: 8355:LOC121394173
uniprot id: A0A1L8G1M1
names: Similarity
messages: Belongs to the HEBP family.

8355:LOC121395627
gene id: 8355:LOC121395627
uniprot id: A0A8J1L7M9
names: Similarity
messages: Belongs to the Izumo family.

8355:ctnnd1.L
gene id: 8355:ctnnd1.L
uniprot id: A0A8J0SZ48
uniprot id: A0A8J0T872
uniprot id: A0A8J1L484
uniprot id: A0A8J1L4A6
uniprot id: B7ZPF5
uniprot id: Q8AXM9
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ARM repeats 1 to 5 mediate interaction with cadherins.
messages: Belongs to the beta-catenin family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed maternally and throughout early embryogenesis. Highly expressed in tissues participating in prominent morphogenetic movements. Enriched in the animal hemisphere in early gastrula and the anterior region in late neurula. Expressed in the head region in the tailbud stage, particularly the optic vesicle, ear vesicle, olfactory placode and branchial arches. Expression is also weakly elevated in the somites, notochord and pronephros.
messages: Interacts with C-cadherin and with zbtb33.
messages: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Required for gastrulation, axial elongation and development of the craniofacial skeleton and eye.
messages: Nucleus
messages: Ubiquitously expressed.
messages: adherens junction

8355:aldh16a1.L
gene id: 8355:aldh16a1.L
uniprot id: A0A1L8FNH9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8355:mios.S
gene id: 8355:mios.S
uniprot id: A0A8J1L0R8
uniprot id: Q5U5D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Belongs to the WD repeat mio family.
messages: Lysosome membrane
messages: Probably part of the GATOR complex.

8355:XB5900552.L
gene id: 8355:XB5900552.L
uniprot id: Q5U5B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:znf687.L
gene id: 8355:znf687.L
uniprot id: A0A8J0TLS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

8355:LOC100037118
gene id: 8355:LOC100037118
uniprot id: A2RRW8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:rpl14.S
gene id: 8355:rpl14.S
uniprot id: Q6NTR4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

8355:LOC108695849
gene id: 8355:LOC108695849
uniprot id: A0A1L8FMD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:gngt2.1.S
gene id: 8355:gngt2.1.S
uniprot id: A0A1L8H7F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:LOC108702072
gene id: 8355:LOC108702072
uniprot id: A0A1L8EZ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:adra2a.L
gene id: 8355:adra2a.L
uniprot id: A0A1L8FI34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:XB964428.S
gene id: 8355:XB964428.S
uniprot id: Q9DEC3
names: Similarity
messages: Belongs to the peptidase A1 family.

8355:LOC108699053
gene id: 8355:LOC108699053
uniprot id: A0A8J1LKT3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:fam83a.L
gene id: 8355:fam83a.L
uniprot id: Q6PF42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM83 family.
messages: Cytoplasm
messages: May function in the epidermal growth factor receptor/EGFR signaling pathway.

8355:LOC108699218
gene id: 8355:LOC108699218
uniprot id: A0A8J0TL10
uniprot id: A0A8J1LIA4
names: Similarity
messages: Belongs to the MHC class I family.

8355:atp5mf.S
gene id: 8355:atp5mf.S
uniprot id: A0A8J0Q006
uniprot id: Q66KN2
names: Function
names: Similarity
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

8355:LOC108701384
gene id: 8355:LOC108701384
uniprot id: A0A8J0TMQ0
names: Subcellular Location Annotation
messages: Nucleus

8355:epo.L
gene id: 8355:epo.L
uniprot id: A0A8J0ULV1
uniprot id: A0A8J0USQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

8355:LOC108702367
gene id: 8355:LOC108702367
uniprot id: A0A8J1LXD5
uniprot id: A0A8J1LXQ3
names: Similarity
messages: Belongs to the ABI family.

8355:hacd2.L
gene id: 8355:hacd2.L
uniprot id: A0A8J1LS93
uniprot id: Q6DCE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:ddx6.S
gene id: 8355:ddx6.S
uniprot id: A0A310UBP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Nucleus

8355:dlst.S
gene id: 8355:dlst.S
uniprot id: Q7ZXF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

8355:ptx3.L
gene id: 8355:ptx3.L
uniprot id: A1L2Q0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108703569
gene id: 8355:LOC108703569
uniprot id: A0A8J0TUW7
uniprot id: A0A8J1MSX6
uniprot id: A0A8J1MUA8
names: Similarity
messages: Belongs to the actin family.

8355:vps41.S
gene id: 8355:vps41.S
uniprot id: A0A8J0UYH3
uniprot id: A0A8J1MQI6
uniprot id: A0A8J1MRL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

8355:LOC108699506
gene id: 8355:LOC108699506
uniprot id: A0A1L8F5Y8
uniprot id: A0A8J1LFT2
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8355:LOC121399772
gene id: 8355:LOC121399772
uniprot id: A0A8J1M6F4
names: Subcellular Location Annotation
messages: Membrane

8355:ube2d4.L
gene id: 8355:ube2d4.L
uniprot id: A0A8J0UQQ2
uniprot id: A5PKP9
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: At embryonic stages 28 to 35, expressed in the somites, eye primordia, otic vesicle and branchial arches. By stage 35, also weakly expressed in the pronephros.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Regulates pronephros development, possibly by promoting ubiquitination and thus inactivation or degradation of map3k10/mlk2.
messages: Expressed maternally. Present at near constant levels throughout early development.
messages: Interacts with map3k10/mlk2.

8355:eif3a.L
gene id: 8355:eif3a.L
uniprot id: A0A1L8FIA3
uniprot id: A0A8J0PPU8
uniprot id: A0A8J1L424
uniprot id: A0A8J1L5S4
uniprot id: A0A8J1L6T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

8355:slc25a23.L
gene id: 8355:slc25a23.L
uniprot id: A0A1L8H352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

8355:fgf10.L
gene id: 8355:fgf10.L
uniprot id: A0A1L8I2C9
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:pts.L
gene id: 8355:pts.L
uniprot id: A0A8J0V0D6
names: Similarity
messages: Belongs to the PTPS family.

8355:nfkb2.L
gene id: 8355:nfkb2.L
uniprot id: A0A1L8FJZ3
uniprot id: A0A8J0TA67
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:emp1.S
gene id: 8355:emp1.S
uniprot id: A0A1L8GGM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

8355:MGC83376
gene id: 8355:MGC83376
uniprot id: A0A8J1M475
uniprot id: Q6DKD6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8355:tmem177.L
gene id: 8355:tmem177.L
uniprot id: A0A1L8EVE0
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

8355:hba2.L
gene id: 8355:hba2.L
uniprot id: P06638
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Red blood cells.
messages: This is a larval (tadpole) alpha-globin.

8355:ambn.L
gene id: 8355:ambn.L
uniprot id: Q6Y4V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

8355:LOC121393647
gene id: 8355:LOC121393647
uniprot id: A0A1L8G7Q0
names: Subcellular Location Annotation
messages: Membrane

8355:slc1a6.S
gene id: 8355:slc1a6.S
uniprot id: A0A1L8HNG2
uniprot id: A0A8J1M3H9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108707586
gene id: 8355:LOC108707586
uniprot id: A0A8J1MBD0
uniprot id: A0A8J1MC51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

8355:abl2.L
gene id: 8355:abl2.L
uniprot id: A0A8J1MVW5
uniprot id: Q6P282
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:tspan12.S
gene id: 8355:tspan12.S
uniprot id: A0A1L8GU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:MGC146443.S
gene id: 8355:MGC146443.S
uniprot id: A0A8J0VDP2
names: Similarity
messages: Belongs to the RNase H family.

8355:LOC108704460
gene id: 8355:LOC108704460
uniprot id: A0A8J1M2T1
uniprot id: A0A8J1M3K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:LOC108707439
gene id: 8355:LOC108707439
uniprot id: A0A8J1M7H5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:alkal1.L
gene id: 8355:alkal1.L
uniprot id: A0A1L8FYY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

8355:dipk2a.S
gene id: 8355:dipk2a.S
uniprot id: A0A1L8G4J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

8355:ube2b.S
gene id: 8355:ube2b.S
uniprot id: Q6GR64
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:dnaaf8.L
gene id: 8355:dnaaf8.L
uniprot id: A0A1L8EYB2
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Dynein axonemal particle
messages: Expression is enriched in multiciliated cells in the epidermis and the nephrostomes of the pronephros.
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.
messages: Interacts with DNAI2.
messages: Mutant multiciliated cells show a severe loss of ODAs from motile cilia.

8355:LOC108716541
gene id: 8355:LOC108716541
uniprot id: A0A1L8G0S1
uniprot id: P84233
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:camkv.L
gene id: 8355:camkv.L
uniprot id: Q6GLS4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasmic vesicle membrane
messages: Does not appear to have detectable kinase activity.
messages: Interacts with calmodulin, in the presence of calcium.
messages: The protein kinase domain is predicted to be catalytically inactive.

8355:rpl7a.S
gene id: 8355:rpl7a.S
uniprot id: Q6GQB2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

8355:LOC108702937
gene id: 8355:LOC108702937
uniprot id: A0A8J1LYH0
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:slc25a18.S
gene id: 8355:slc25a18.S
uniprot id: A0A8J1MQY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:rarres1.L
gene id: 8355:rarres1.L
uniprot id: A0A8J0V9C6
uniprot id: Q6PB09
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

8355:cldn6.2.S
gene id: 8355:cldn6.2.S
uniprot id: Q5EAT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:cenpk.L
gene id: 8355:cenpk.L
uniprot id: Q5XGL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere
messages: kinetochore

8355:chaf1a.L
gene id: 8355:chaf1a.L
uniprot id: Q98TA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHAF1A family.
messages: Homodimer.
messages: Involved in chromatin assembly in DNA replication and DNA repair.
messages: Nucleus

8355:LOC108719403
gene id: 8355:LOC108719403
uniprot id: A0A8J1KZ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

8355:plscr4.S
gene id: 8355:plscr4.S
uniprot id: A0A8J1MU97
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8355:LOC108702189
gene id: 8355:LOC108702189
uniprot id: A0A8J1LZ91
uniprot id: A0A8J1LZB4
uniprot id: A0A8J1LZG2
uniprot id: A0A8J1M0I4
uniprot id: A0A8J1M1F2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

8355:ulk3.L
gene id: 8355:ulk3.L
uniprot id: Q4V7Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: Cytoplasm
messages: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.

8355:camsap1.S
gene id: 8355:camsap1.S
uniprot id: A0A8J1LKR0
uniprot id: Q6IRN6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMSAP1 family.
messages: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to camsap2 and camsap3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth.
messages: The CKK domain binds microtubules.
messages: cytoskeleton

8355:med10.S
gene id: 8355:med10.S
uniprot id: Q6IP67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8355:esrra.S
gene id: 8355:esrra.S
uniprot id: A0A1L8GD98
uniprot id: A0A8J0V5S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8355:dipk2a.L
gene id: 8355:dipk2a.L
uniprot id: A0A1L8GAY8
uniprot id: Q4V7R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

8355:cacna2d3.S
gene id: 8355:cacna2d3.S
uniprot id: Q8AVY7
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

8355:LOC108699049
gene id: 8355:LOC108699049
uniprot id: A0A8J0TJ13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108719956
gene id: 8355:LOC108719956
uniprot id: A0A1L8FRD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8355:ppp1r15b-b
gene id: 8355:ppp1r15b-b
uniprot id: Q5U4R3
names: Similarity
messages: Belongs to the PPP1R15 family.

8355:lgi2.S
gene id: 8355:lgi2.S
uniprot id: A0A1L8HL09
names: Subcellular Location Annotation
messages: Secreted

8355:ric3.S
gene id: 8355:ric3.S
uniprot id: A0A8J1MZZ4
uniprot id: C6ZEC3
names: Similarity
messages: Belongs to the ric-3 family.

8355:vopp1.S
gene id: 8355:vopp1.S
uniprot id: Q5XGS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: May be involved in the transcriptional activity of NFKB1.

8355:LOC100036976
gene id: 8355:LOC100036976
uniprot id: A1L2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:rprml.L
gene id: 8355:rprml.L
uniprot id: Q6GM22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Membrane

8355:LOC121395628
gene id: 8355:LOC121395628
uniprot id: A0A1L8FNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

8355:tlcd4.S
gene id: 8355:tlcd4.S
uniprot id: A0A1L8GG55
uniprot id: A0A8J0V3A5
uniprot id: Q6PGS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLCD4 family.
messages: Membrane

8355:LOC108701660
gene id: 8355:LOC108701660
uniprot id: A0A8J0TP05
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

8355:krt7.L
gene id: 8355:krt7.L
uniprot id: P16878
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Blocks interferon-dependent interphase and stimulates DNA synthesis in cells.
messages: Cytoplasm
messages: Expressed first at gastrulation (stage 11) and is found to rapidly increase during neurulation and further development. In the adult, it is a major polypeptide in the esophageal mucosa.
messages: Heterotetramer of two type I and two type II keratins.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

8355:oc90.S
gene id: 8355:oc90.S
uniprot id: A0A8J1L331
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

8355:echs1.L
gene id: 8355:echs1.L
uniprot id: A0A1L8FKI1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8355:per2.L
gene id: 8355:per2.L
uniprot id: Q9DG29
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:LOC121397994
gene id: 8355:LOC121397994
uniprot id: A0A8J1LRR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:myo1f.L
gene id: 8355:myo1f.L
uniprot id: A0A8J1M3Y8
uniprot id: Q6GME8
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108713530
gene id: 8355:LOC108713530
uniprot id: A0A1L8GM88
uniprot id: A0A8J1MWW0
uniprot id: A0A8J1MY25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Membrane

8355:psma2.S
gene id: 8355:psma2.S
uniprot id: P24495
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

8355:b3gnt5.S
gene id: 8355:b3gnt5.S
uniprot id: A0A8J1KRM8
uniprot id: Q6DE15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108719847
gene id: 8355:LOC108719847
uniprot id: A0A8J1L1A0
uniprot id: A0A8J1L1A1
uniprot id: A0A8J1L1A6
uniprot id: A0A8J1L1A7
uniprot id: A0A8J1L1B5
uniprot id: A0A8J1L1B9
uniprot id: A0A8J1L2W9
uniprot id: A0A8J1L421
uniprot id: A0A8J1L426
names: Similarity
messages: Belongs to the villin/gelsolin family.

8355:phb.S
gene id: 8355:phb.S
uniprot id: A0A1L8EKW3
uniprot id: Q7SY83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

8355:tff3.8.S
gene id: 8355:tff3.8.S
uniprot id: B7ZQR4
uniprot id: Q00223
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Glycosylated.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May act as a growth factor.
messages: Secreted
messages: Stomach mucosa.

8355:LOC108703540
gene id: 8355:LOC108703540
uniprot id: A0A8J0TUT2
uniprot id: A0A8J0U2F3
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121399708
gene id: 8355:LOC121399708
uniprot id: A0A8J1M664
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:dcc.S
gene id: 8355:dcc.S
uniprot id: A0A8J0UB97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

8355:gsto1.S
gene id: 8355:gsto1.S
uniprot id: A0A8J0TDU2
uniprot id: Q5U546
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

8355:tyrp1.S
gene id: 8355:tyrp1.S
uniprot id: A0A1L8HNZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8355:fnta.S
gene id: 8355:fnta.S
uniprot id: A9ULW7
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

8355:hhatl.S
gene id: 8355:hhatl.S
uniprot id: Q7ZYD3
names: Subcellular Location Annotation
messages: Membrane

8355:baf-l.L
gene id: 8355:baf-l.L
uniprot id: Q5HZM3
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus

8355:tmbim4.L
gene id: 8355:tmbim4.L
uniprot id: Q5EAW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8355:LOC121394513
gene id: 8355:LOC121394513
uniprot id: A0A1L8HZP6
names: Subcellular Location Annotation
messages: Secreted

8355:gng12.S
gene id: 8355:gng12.S
uniprot id: A0A1L8GLU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:degs1.L
gene id: 8355:degs1.L
uniprot id: A0A1L8G6I2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane

8355:reep5.L
gene id: 8355:reep5.L
uniprot id: A0A8J1MBD7
uniprot id: Q3KQ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

8355:arl9.L
gene id: 8355:arl9.L
uniprot id: A0A8J1MDK2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8355:mfsd14bl.S
gene id: 8355:mfsd14bl.S
uniprot id: A0A1L8HPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

8355:dmtn.L
gene id: 8355:dmtn.L
uniprot id: A0A1L8H209
uniprot id: A0A8J0URF6
uniprot id: Q6GP90
names: Subcellular Location Annotation
messages: Cytoplasm

8355:xpo7.L
gene id: 8355:xpo7.L
uniprot id: Q569Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Mediates the nuclear export of proteins (cargos) with broad substrate specificity.
messages: Nucleus

8355:LOC108697721
gene id: 8355:LOC108697721
uniprot id: A0A1L8FGK2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:LOC108710432
gene id: 8355:LOC108710432
uniprot id: A0A1L8H3K5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ints3.L
gene id: 8355:ints3.L
uniprot id: A0A1L8FD93
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

8355:tfe3.S
gene id: 8355:tfe3.S
uniprot id: Q5XHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

8355:triap1.L
gene id: 8355:triap1.L
uniprot id: Q6DD38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRIAP1/MDM35 family.
messages: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. The triap1:prelid1 complex probably functions as a phosphatidic acid (PA) transporter across the mitochondrion intermembrane space to provide PA for cardiolipin CL synthesis in the inner membrane. Likewise, the triap1:prelid3a complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (By similarity). Required for pronephros development; probably involved at an early stage in the formation of pronephric components derived from the somatic layer (By similarity).
messages: Mitochondrion
messages: Mitochondrion intermembrane space
messages: Monomer. Forms a complex with prelid1 in the mitochondrion intermembrane space. Interacts with prelid3a.

8355:LOC121393805
gene id: 8355:LOC121393805
uniprot id: Q5I9F3
names: Similarity
messages: Belongs to the TGF-beta family.

8355:LOC121401303
gene id: 8355:LOC121401303
uniprot id: A0A8J1MJP9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:aga.L
gene id: 8355:aga.L
uniprot id: Q5M7B8
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

8355:wscd2.L
gene id: 8355:wscd2.L
uniprot id: A0A1L8I1F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

8355:LOC108699091
gene id: 8355:LOC108699091
uniprot id: A0A1L8FC06
names: Subcellular Location Annotation
messages: Membrane

8355:ctss.S
gene id: 8355:ctss.S
uniprot id: Q6DE57
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:anxa5.L
gene id: 8355:anxa5.L
uniprot id: Q6DDD9
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

8355:LOC121393655
gene id: 8355:LOC121393655
uniprot id: A0A8J1KPI4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108707475
gene id: 8355:LOC108707475
uniprot id: A0A8J1M825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

8355:LOC108707142
gene id: 8355:LOC108707142
uniprot id: A0A1L8HQH6
uniprot id: A0A8J0U231
uniprot id: A0A8J0U944
uniprot id: A0A8J0UAF2
names: Subcellular Location Annotation
messages: Nucleus

8355:pglyrp1.S
gene id: 8355:pglyrp1.S
uniprot id: Q5PPZ4
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

8355:ik.L
gene id: 8355:ik.L
uniprot id: A0A1L8GX20
uniprot id: Q6DDH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

8355:ankrd13c.S
gene id: 8355:ankrd13c.S
uniprot id: Q7ZYD9
names: Function
names: Subcellular Location Annotation
messages: Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
messages: Endoplasmic reticulum membrane

8355:LOC108704363
gene id: 8355:LOC108704363
uniprot id: A0A8J0U535
uniprot id: A0A8J0U767
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

8355:LOC495518
gene id: 8355:LOC495518
uniprot id: Q5U487
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8355:grp.L
gene id: 8355:grp.L
uniprot id: A0A1L8I2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: secretory vesicle lumen

8355:LOC121402968
gene id: 8355:LOC121402968
uniprot id: A0A8J1MY47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:slc43a2.S
gene id: 8355:slc43a2.S
uniprot id: A2RRX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
messages: Membrane

8355:gpc4.L
gene id: 8355:gpc4.L
uniprot id: A0A8J0THZ8
uniprot id: Q5EAV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

8355:LOC108717647
gene id: 8355:LOC108717647
uniprot id: A0A1L8G0S8
uniprot id: P62799
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8355:LOC108701868
gene id: 8355:LOC108701868
uniprot id: A0A1L8EX45
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:lyplal1.L
gene id: 8355:lyplal1.L
uniprot id: A0A1L8G6B3
uniprot id: A0A8J0V6D1
uniprot id: A0A8J1KMC1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

8355:cd81.S
gene id: 8355:cd81.S
uniprot id: Q6DCU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:ube2l3.L
gene id: 8355:ube2l3.L
uniprot id: Q4QR35
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:wnt6.S
gene id: 8355:wnt6.S
uniprot id: B0FK91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:psmd11.S
gene id: 8355:psmd11.S
uniprot id: A0A1L8EL57
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

8355:LOC108702601
gene id: 8355:LOC108702601
uniprot id: A0A1L8ELK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8355:LOC108708797
gene id: 8355:LOC108708797
uniprot id: A0A8J1MAT1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:cyp2a6.8.L
gene id: 8355:cyp2a6.8.L
uniprot id: Q6IR71
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:elovl5.L
gene id: 8355:elovl5.L
uniprot id: Q498J8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: dendrite

8355:LOC108703502
gene id: 8355:LOC108703502
uniprot id: A0A8J1MSQ9
names: Subcellular Location Annotation
messages: Secreted

8355:mpdz.L
gene id: 8355:mpdz.L
uniprot id: A0A1L8HY06
uniprot id: A0A8J0V129
uniprot id: A0A8J1KR51
uniprot id: A0A8J1KR66
uniprot id: A0A8J1KR75
uniprot id: A0A8J1KR79
uniprot id: A0A8J1KR85
uniprot id: A0A8J1KSQ1
uniprot id: A0A8J1KST6
uniprot id: A0A8J1KUB3
uniprot id: A0A8J1KUC4
names: Subcellular Location Annotation
messages: tight junction

8355:rpl17.S
gene id: 8355:rpl17.S
uniprot id: Q6AZV3
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

8355:gpr107.S
gene id: 8355:gpr107.S
uniprot id: Q5XG03
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108695447
gene id: 8355:LOC108695447
uniprot id: A0A8J0T8F1
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:mmachc.L
gene id: 8355:mmachc.L
uniprot id: A0A1L8GM62
uniprot id: A0A8J0V151
names: Similarity
messages: Belongs to the MMACHC family.

8355:LOC108718739
gene id: 8355:LOC108718739
uniprot id: A0A8J1L092
names: Similarity
messages: Belongs to the polyadenylate-binding protein type-1 family.

8355:ndnfl1.1.L
gene id: 8355:ndnfl1.1.L
uniprot id: A0A1L8GWR8
names: Subcellular Location Annotation
messages: Secreted

8355:scn3b.S
gene id: 8355:scn3b.S
uniprot id: A0A1L8FFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

8355:LOC108717500
gene id: 8355:LOC108717500
uniprot id: A0A8J1KV24
names: Subcellular Location Annotation
messages: Membrane

8355:st8sia5.L
gene id: 8355:st8sia5.L
uniprot id: A0A1L8I2W8
uniprot id: A0A8J1LC15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:rpl10a.S
gene id: 8355:rpl10a.S
uniprot id: Q7ZYS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8355:crisp1.9.L
gene id: 8355:crisp1.9.L
uniprot id: A0A1L8GC19
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108707926
gene id: 8355:LOC108707926
uniprot id: A0A1L8HCY5
names: Subcellular Location Annotation
messages: Membrane

8355:slc35a5.S
gene id: 8355:slc35a5.S
uniprot id: A0A1L8H6P2
uniprot id: Q6DCG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

8355:LOC108697005
gene id: 8355:LOC108697005
uniprot id: A0A1L8HZG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ribc1.L
gene id: 8355:ribc1.L
uniprot id: A0A8J1LEW1
uniprot id: A0A8J1LEX7
uniprot id: A0A8J1LEY1
uniprot id: A0A8J1LFA3
uniprot id: A0A8J1LFA8
uniprot id: A0A8J1LGC9
uniprot id: A0A8J1LHD1
uniprot id: Q3B8E2
names: Similarity
messages: Belongs to the RIB43A family.

8355:LOC108696942
gene id: 8355:LOC108696942
uniprot id: A0A1L8FPX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

8355:tom1l2.L
gene id: 8355:tom1l2.L
uniprot id: Q68FJ8
names: Function
names: Similarity
names: Subunit
messages: Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (By similarity). May also play a role in recruiting clathrin to endosomes (By similarity). May regulate growth factor-induced mitogenic signaling (By similarity).
messages: Belongs to the TOM1 family.
messages: Interacts with clathrin. Interacts with MYO6 (By similarity).

8355:LOC121394451
gene id: 8355:LOC121394451
uniprot id: A0A8J1KZ52
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC108716300
gene id: 8355:LOC108716300
uniprot id: A0A8J0VAD9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108715419
gene id: 8355:LOC108715419
uniprot id: A0A1L8GF08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:nphp3.L
gene id: 8355:nphp3.L
uniprot id: Q6AZT7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Bilateral morpholino knockdown of the protein in the embryo causes gross body edema that is typical of a renal excretory defect.
messages: Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
messages: cilium

8355:mogs.L
gene id: 8355:mogs.L
uniprot id: B1WBB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

8355:slu7.L
gene id: 8355:slu7.L
uniprot id: A0A1L8GX04
uniprot id: Q3KQD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Nucleus
messages: Nucleus speckle
messages: Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

8355:LOC108708210
gene id: 8355:LOC108708210
uniprot id: A0A1L8HF98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

8355:tll2l.L
gene id: 8355:tll2l.L
uniprot id: B1H1V3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mettl14.L
gene id: 8355:mettl14.L
uniprot id: A0A8J0U8W5
uniprot id: A0A8J0U984
uniprot id: A0A8J1LX22
uniprot id: A0A8J1LZC0
uniprot id: Q6NU56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with mettl3 to form an antiparallel heterodimer that constitutes an active methyltransferase. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of mettl3 and mettl14.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing.

8355:tmem251.L
gene id: 8355:tmem251.L
uniprot id: A0A1L8F9L9
uniprot id: Q66J17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Belongs to the TMEM251 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases.

8355:ak4.L
gene id: 8355:ak4.L
uniprot id: A0A1L8GLX1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion matrix
messages: Monomer.

8355:LOC108700563
gene id: 8355:LOC108700563
uniprot id: A0A1L8F3I3
names: Subcellular Location Annotation
messages: Membrane

8355:bmp7.2.S
gene id: 8355:bmp7.2.S
uniprot id: A0A1L8GT31
names: Similarity
messages: Belongs to the TGF-beta family.

8355:LOC121402230
gene id: 8355:LOC121402230
uniprot id: A0A8J1MSH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:pank4.S
gene id: 8355:pank4.S
uniprot id: A0A1L8FG60
names: Similarity
names: Subunit
messages: Belongs to the type II pantothenate kinase family.
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.

8355:clptm1.S
gene id: 8355:clptm1.S
uniprot id: A0A1L8F3I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

8355:LOC108698667
gene id: 8355:LOC108698667
uniprot id: A0A1L8F980
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

8355:LOC121395511
gene id: 8355:LOC121395511
uniprot id: A0A1L8FP06
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108705572
gene id: 8355:LOC108705572
uniprot id: A0A8J1L0V9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8355:bola1.L
gene id: 8355:bola1.L
uniprot id: A0A1L8FBX4
uniprot id: A0A8J0TK02
names: Similarity
messages: Belongs to the BolA/IbaG family.

8355:XB5895996.L
gene id: 8355:XB5895996.L
uniprot id: A0A8J0U520
uniprot id: A5D8M7
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8355:ide.L
gene id: 8355:ide.L
uniprot id: A0A8J0T9N5
uniprot id: A0A8J1L7M3
names: Similarity
messages: Belongs to the peptidase M16 family.

8355:LOC108719617
gene id: 8355:LOC108719617
uniprot id: A0A8J1MY29
names: Subcellular Location Annotation
messages: Membrane

8355:irf2bp2.L
gene id: 8355:irf2bp2.L
uniprot id: A0A1L8G830
uniprot id: Q7ZXS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor.
messages: Belongs to the IRF2BP family.
messages: Nucleus

8355:phaf1.L
gene id: 8355:phaf1.L
uniprot id: A0A1L8GKR8
names: Similarity
messages: Belongs to the PHAF1 family.

8355:LOC121393725
gene id: 8355:LOC121393725
uniprot id: A0A8J1KNV9
uniprot id: A0A8J1KQJ8
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

8355:enah.S
gene id: 8355:enah.S
uniprot id: A0A1L8G107
uniprot id: A0A8J0VEJ7
uniprot id: A0A8J0VIY9
uniprot id: Q4V859
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: cytoskeleton

8355:txnrd1.L
gene id: 8355:txnrd1.L
uniprot id: A0A8J0Q013
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

8355:mmgt1.S
gene id: 8355:mmgt1.S
uniprot id: Q6GQ49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Component of the ER membrane protein complex (EMC).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport (By similarity).

8355:XB5796356.S
gene id: 8355:XB5796356.S
uniprot id: A0A1L8G5W8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rdh20.L
gene id: 8355:rdh20.L
uniprot id: A0A1L8ESN1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:dis3l2.L
gene id: 8355:dis3l2.L
uniprot id: A0A8J0TXG8
uniprot id: A0A8J0U839
uniprot id: A0A8J1KSH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

8355:slc35f1.L
gene id: 8355:slc35f1.L
uniprot id: A0A1L8G8X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

8355:LOC108701900
gene id: 8355:LOC108701900
uniprot id: A0A8J1LT68
uniprot id: A0A8J1LUP1
uniprot id: A0A8J1LVK8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

8355:ltb.L
gene id: 8355:ltb.L
uniprot id: A0A1L8F8I5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:tdgf1.3.L
gene id: 8355:tdgf1.3.L
uniprot id: A0A8J0TL66
uniprot id: Q91649
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.

8355:p2rx4.L
gene id: 8355:p2rx4.L
uniprot id: A0A8J0TNY2
uniprot id: A0A8J0TW83
uniprot id: Q9DDP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8355:LOC121400818
gene id: 8355:LOC121400818
uniprot id: A0A8J1MH41
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:sh3gl2.L
gene id: 8355:sh3gl2.L
uniprot id: Q5HZS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

8355:LOC121402270
gene id: 8355:LOC121402270
uniprot id: A0A8J1MUX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:cdc6.S
gene id: 8355:cdc6.S
uniprot id: P79946
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

8355:glyr1.L
gene id: 8355:glyr1.L
uniprot id: A0A1L8EYV2
uniprot id: A0A8J0TP69
uniprot id: A0A8J0TWM6
uniprot id: A0A8J0TXS2
uniprot id: A0A8J0TZA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

8355:gtpbp8.L
gene id: 8355:gtpbp8.L
uniprot id: A0A1L8HCA1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

8355:mapk14.S
gene id: 8355:mapk14.S
uniprot id: A0A8J0UHZ4
uniprot id: D2KW21
uniprot id: P47812
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Dually phosphorylated on Thr-181 and Tyr-183, which activates the enzyme.
messages: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. MPK2 is activated by upstream MAPKK/MAPKKK and stimulates MAPKAP kinase 2 to phosphorylate small heat shock proteins. Does not phosphorylate myelin basic protein or MAPKAP kinase 1.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

8355:antxr1.L
gene id: 8355:antxr1.L
uniprot id: A0A1L8H1F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

8355:znf326.L
gene id: 8355:znf326.L
uniprot id: A0A1L8GMX3
uniprot id: A0A8J0V2I4
names: Similarity
messages: Belongs to the AKAP95 family.

8355:LOC108710791
gene id: 8355:LOC108710791
uniprot id: A0A1L8GWK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:setd2.S
gene id: 8355:setd2.S
uniprot id: A0A8J1L133
uniprot id: A0A8J1L150
uniprot id: A0A8J1L2P7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108703468
gene id: 8355:LOC108703468
uniprot id: A0A8J0U517
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:galr2.L
gene id: 8355:galr2.L
uniprot id: A0A1L8EUK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:ak1.S
gene id: 8355:ak1.S
uniprot id: A0A1L8F1P8
uniprot id: A0A8J0TET3
uniprot id: A0A8J0TMK8
uniprot id: Q6GQF9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

8355:trpm6.L
gene id: 8355:trpm6.L
uniprot id: A0A1L8HYE9
uniprot id: A0A8J1KTX9
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

8355:cldn15.2.L
gene id: 8355:cldn15.2.L
uniprot id: A0A1L8GBB6
uniprot id: A0A1L8GBF2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:neurod6.L
gene id: 8355:neurod6.L
uniprot id: B7ZSJ0
uniprot id: Q9DDQ8
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8355:map3k13.S
gene id: 8355:map3k13.S
uniprot id: A0A1L8EPW4
uniprot id: A7J1T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May have a role in the JNK signaling pathway.
messages: Membrane

8355:hmbs.2.S
gene id: 8355:hmbs.2.S
uniprot id: A0A8J0U5M5
uniprot id: Q5XH11
names: Similarity
messages: Belongs to the HMBS family.

8355:hyal1.L
gene id: 8355:hyal1.L
uniprot id: A0A1L8GP88
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

8355:nell1.L
gene id: 8355:nell1.L
uniprot id: A0A8J0QFH6
uniprot id: A0A8J1MTL5
uniprot id: A0A8J1MTM0
uniprot id: A0A8J1MUP6
uniprot id: A0A8J1MV12
uniprot id: A0A8J1MVY7
uniprot id: A0A8J1MVZ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:kdelr2.L
gene id: 8355:kdelr2.L
uniprot id: Q7ZXS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).

8355:XB5962511.L
gene id: 8355:XB5962511.L
uniprot id: A0A1L8EYU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:impg2.S
gene id: 8355:impg2.S
uniprot id: A0A1L8H8J7
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

8355:LOC108700492
gene id: 8355:LOC108700492
uniprot id: A0A1L8F0L2
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

8355:ppfia1.S
gene id: 8355:ppfia1.S
uniprot id: A0A8J1MZM4
uniprot id: A0A8J1MZN3
uniprot id: A0A8J1MZX5
uniprot id: A0A8J1MZY0
uniprot id: A0A8J1MZY6
uniprot id: A0A8J1N0U5
uniprot id: A0A8J1N0V0
uniprot id: A0A8J1N0V5
uniprot id: A0A8J1N0W0
uniprot id: A0A8J1N1M6
uniprot id: A0A8J1N1N3
uniprot id: A0A8J1N1N8
uniprot id: A0A8J1N2D9
uniprot id: A0A8J1N2E5
uniprot id: A0A8J1N2F2
uniprot id: Q5HZP9
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

8355:coe3l.L
gene id: 8355:coe3l.L
uniprot id: A0A1L8HSM8
uniprot id: A0A8J0T5T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

8355:atf7.L
gene id: 8355:atf7.L
uniprot id: A0A8J0UGR2
uniprot id: A0A8J1MBR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

8355:LOC108718577
gene id: 8355:LOC108718577
uniprot id: A0A8J1KZ96
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108704825
gene id: 8355:LOC108704825
uniprot id: A0A8J0U656
names: Subcellular Location Annotation
messages: Membrane

8355:fhip2a.L
gene id: 8355:fhip2a.L
uniprot id: A0A1L8FI64
names: Similarity
messages: Belongs to the FHIP family.

8355:tcea2.S
gene id: 8355:tcea2.S
uniprot id: Q91692
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

8355:syne3.S
gene id: 8355:syne3.S
uniprot id: A0A8J0TFP2
uniprot id: A0A8J0TM49
names: Similarity
messages: Belongs to the nesprin family.

8355:LOC108711766
gene id: 8355:LOC108711766
uniprot id: A0A8J0USI6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108715506
gene id: 8355:LOC108715506
uniprot id: A0A1L8GF89
names: Similarity
messages: Belongs to the adenylate kinase family.

8355:snap91.S
gene id: 8355:snap91.S
uniprot id: A0A1L8G3C6
uniprot id: A0A8J0VIN8
uniprot id: A0A8J1KRC1
uniprot id: A0A8J1KRC6
uniprot id: A0A8J1KRE6
uniprot id: A0A8J1KRF1
uniprot id: A0A8J1KRF4
uniprot id: A0A8J1KRF6
uniprot id: A0A8J1KRF9
uniprot id: A0A8J1KRG1
uniprot id: A0A8J1KRG3
uniprot id: A0A8J1KRG8
uniprot id: A0A8J1KT00
uniprot id: A0A8J1KT04
uniprot id: A0A8J1KT09
uniprot id: A0A8J1KUH5
uniprot id: A0A8J1KUH9
uniprot id: A0A8J1KUI9
uniprot id: Q9PTK7
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

8355:mettl16.L
gene id: 8355:mettl16.L
uniprot id: Q6GR37
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Methyltransferase activity is autoinhibited by the K-loop region that blocks S-adenosyl-L-methionine-binding. Upon activation, K-loop changes conformation, allowing S-adenosyl-L-methionine-binding and subsequent methyltransferase activity. mRNA N6-adenosine-methyltransferase activity is inhibited by zinc.
messages: Nucleus
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A splicing and protein expression. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs.
messages: The K-loop region occludes the S-adenosyl-L-methionine-binding pocket. Upon activation, conformation of the K-loop changes, allowing S-adenosyl-L-methionine-binding.
messages: The VCR (vertebrate conserved) regions bind the first hairpin of MAT2A mRNAs. The VCR regions interact with the internal stem-loop within U6 snRNAs, inducing the conformational rearrangement of the A43-containing region of U6 snRNA, thereby modifying the RNA structure to become suitable for productive catalysis by the methyltransferase region.

8355:LOC108716663
gene id: 8355:LOC108716663
uniprot id: A0A1L8G7Q9
uniprot id: A0A8J0V778
uniprot id: A0A8J0VA97
uniprot id: A0A8J0VAV6
uniprot id: A0A8J0VAW1
uniprot id: A0A8J0VBK7
uniprot id: A0A8J0VFT1
uniprot id: A0A8J1KMT8
uniprot id: A0A8J1KMT9
uniprot id: A0A8J1KMU3
uniprot id: A0A8J1KMU4
uniprot id: A0A8J1KMV2
uniprot id: A0A8J1KMV7
uniprot id: A0A8J1KPH4
uniprot id: A0A8J1KPH9
uniprot id: A0A8J1KQY5
uniprot id: A0A8J1KQZ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:gja8.L
gene id: 8355:gja8.L
uniprot id: A0A8J0UC39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:LOC121396576
gene id: 8355:LOC121396576
uniprot id: A0A8J1LDI4
uniprot id: A0A8J1LDS8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

8355:gask1b.L
gene id: 8355:gask1b.L
uniprot id: A0A1L8HU88
names: Similarity
messages: Belongs to the GASK family.

8355:LOC108717376
gene id: 8355:LOC108717376
uniprot id: A0A1L8G0U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

8355:xirp1.S
gene id: 8355:xirp1.S
uniprot id: A0A8J1L6J8
names: Domain
names: Similarity
messages: Belongs to the Xin family.
messages: Xin repeats bind F-actin.

8355:mus81.L
gene id: 8355:mus81.L
uniprot id: A0A1L8GJY4
uniprot id: A0A8J0V115
uniprot id: A0A8J0V4V2
uniprot id: A0A8J1MW06
uniprot id: A0A8J1MXD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

8355:LOC108719140
gene id: 8355:LOC108719140
uniprot id: A0A1L8FY22
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

8355:amd1.L
gene id: 8355:amd1.L
uniprot id: A0A8J1KL21
uniprot id: P79888
names: Caution
names: Cofactor
names: Developmental Stage
names: Function
names: PTM
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: First expressed at stage I of oocyte development, and is maximally expressed at stage II. Levels decline during oocyte maturation and after fertilization, and also in the early neurula. Levels increase dramatically during the late neurula stage reaching a maximum at the tail bud stage.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain (By similarity).
messages: It is uncertain whether Met-1 or Met-3 is the initiator.

8355:LOC108712492
gene id: 8355:LOC108712492
uniprot id: P16501
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed both maternally and zygotically after the midblastula transition. Present both dorsally and ventrally at the beginning of neurulation. Expression is restricted to the developing heart at the tailbud stage.
messages: Expressed in adult liver, lung, heart, kidney and peritoneal fat.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes head development by inhibiting Wnt signaling during embryogenesis (PubMed:11709186, PubMed:11944947). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling (By similarity).

8355:rpl26.S
gene id: 8355:rpl26.S
uniprot id: A0A1L8GV48
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

8355:pdcl.S
gene id: 8355:pdcl.S
uniprot id: A0A1L8F231
names: Similarity
messages: Belongs to the phosducin family.

8355:pou1f1.L
gene id: 8355:pou1f1.L
uniprot id: A0A8J1M754
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus

8355:LOC121393952
gene id: 8355:LOC121393952
uniprot id: A0A8J1KSK4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:LOC108710449
gene id: 8355:LOC108710449
uniprot id: A0A8J1MIP4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ctgfl.L
gene id: 8355:ctgfl.L
uniprot id: A0A1L8F8K5
uniprot id: A0A8J1LHL1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tec.S
gene id: 8355:tec.S
uniprot id: A0A8J1M241
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:smpd1.L
gene id: 8355:smpd1.L
uniprot id: A0A1L8HJP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.
messages: Secreted

8355:XB5893022.L
gene id: 8355:XB5893022.L
uniprot id: A0A1L8FK46
uniprot id: A0A8J0TA34
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ppfia1.L
gene id: 8355:ppfia1.L
uniprot id: A0A1L8GIV1
uniprot id: A0A8J1MV73
uniprot id: A0A8J1MV80
uniprot id: A0A8J1MVG7
uniprot id: A0A8J1MVH1
uniprot id: A0A8J1MVH7
uniprot id: A0A8J1MWC9
uniprot id: A0A8J1MWD3
uniprot id: A0A8J1MWR4
uniprot id: A0A8J1MWS0
uniprot id: A0A8J1MXN6
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

8355:lpar3.L
gene id: 8355:lpar3.L
uniprot id: A0A1L8GLP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121394744
gene id: 8355:LOC121394744
uniprot id: A0A8J1KYP5
uniprot id: A0A8J1L0C2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:cyp39a1.L
gene id: 8355:cyp39a1.L
uniprot id: A1A611
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

8355:slc6a5.S
gene id: 8355:slc6a5.S
uniprot id: B7ZRV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:pdk1.L
gene id: 8355:pdk1.L
uniprot id: Q6IR88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

8355:hsp30c.L
gene id: 8355:hsp30c.L
uniprot id: P30218
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:plppr5.S
gene id: 8355:plppr5.S
uniprot id: A0A1L8GG66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:LOC121395749
gene id: 8355:LOC121395749
uniprot id: A0A1L8FIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:pitrm1.L
gene id: 8355:pitrm1.L
uniprot id: A0A1L8FVA3
uniprot id: Q6PF24
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A disulfide bond locks the enzyme in the closed conformation preventing substrate entry into the catalytic chamber.
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Mainly exists in a closed and catalytically competent conformation but a closed-to-open switch allows substrate entry into the catalytic chamber. Substrate binding induces closure and dimerization. A disulfide bond may lock the enzyme in a closed conformation preventing substrate entry into the catalytic chamber, participating in redox regulation of the enzyme. Inhibited by metal-chelating agents. Inhibited by nickel and zinc excess, and slightly activated by manganese.
messages: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides.
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

8355:cdc6.L
gene id: 8355:cdc6.L
uniprot id: Q6IP89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

8355:neto2.L
gene id: 8355:neto2.L
uniprot id: A0A1L8GL92
uniprot id: A0A8J1MWC7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:slc35b2.S
gene id: 8355:slc35b2.S
uniprot id: Q7ZXL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

8355:LOC121398138
gene id: 8355:LOC121398138
uniprot id: A0A1L8EU36
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:akap13.L
gene id: 8355:akap13.L
uniprot id: A0A8J0USH3
uniprot id: A0A8J1MLZ0
uniprot id: A0A8J1MLZ6
uniprot id: A0A8J1MM05
uniprot id: A0A8J1MM31
uniprot id: A0A8J1MM36
uniprot id: A0A8J1MMX8
uniprot id: A0A8J1MMY8
uniprot id: A0A8J1MMZ0
uniprot id: A0A8J1MMZ5
uniprot id: A0A8J1MP22
uniprot id: A0A8J1MP27
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108696623
gene id: 8355:LOC108696623
uniprot id: A0A1L8FMM8
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

8355:tmem33.L
gene id: 8355:tmem33.L
uniprot id: A0A8J0UE38
uniprot id: Q6DFH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

8355:LOC121403155
gene id: 8355:LOC121403155
uniprot id: A0A8J1N172
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:tspan11.S
gene id: 8355:tspan11.S
uniprot id: A0A1L8GQR8
uniprot id: A0A8J1MR94
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:sugp1.L
gene id: 8355:sugp1.L
uniprot id: A0A8J0UTN5
names: Subcellular Location Annotation
messages: Nucleus

8355:MGC114621
gene id: 8355:MGC114621
uniprot id: Q4V871
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

8355:atp6v0e1.L
gene id: 8355:atp6v0e1.L
uniprot id: Q6AZJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8355:rrad.S
gene id: 8355:rrad.S
uniprot id: A0A8J0U6L2
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

8355:esr1.S
gene id: 8355:esr1.S
uniprot id: A0A8J0VE87
uniprot id: B2NIY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

8355:ei24.L
gene id: 8355:ei24.L
uniprot id: A0A1L8FL56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

8355:LOC108718044
gene id: 8355:LOC108718044
uniprot id: A0A1L8G3U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

8355:dr1.L
gene id: 8355:dr1.L
uniprot id: A0A1L8GMS5
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

8355:gxylt2.L
gene id: 8355:gxylt2.L
uniprot id: A0A1L8GPY2
names: Subcellular Location Annotation
messages: Membrane

8355:ocm3.S
gene id: 8355:ocm3.S
uniprot id: A9JS16
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8355:LOC121403129
gene id: 8355:LOC121403129
uniprot id: A0A8J1MY80
uniprot id: A0A8J1MYG7
names: Similarity
messages: Belongs to the TAFA family.

8355:LOC108716280
gene id: 8355:LOC108716280
uniprot id: A0A8J1KR35
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121397317
gene id: 8355:LOC121397317
uniprot id: A0A8J1LK33
names: Subcellular Location Annotation
messages: Membrane

8355:hlf.S
gene id: 8355:hlf.S
uniprot id: A0A8J0U3W8
uniprot id: A0A8J0U6P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

8355:galnt6.2.S
gene id: 8355:galnt6.2.S
uniprot id: A0A8J0UPQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:creb1.S
gene id: 8355:creb1.S
uniprot id: A0A8J0TX94
uniprot id: Q8AVY5
names: Subcellular Location Annotation
messages: Nucleus

8355:sod3.L
gene id: 8355:sod3.L
uniprot id: A0A1L8HTF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

8355:LOC121397087
gene id: 8355:LOC121397087
uniprot id: A0A8J1LHD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:gpt.L
gene id: 8355:gpt.L
uniprot id: A0A8J0VMT4
uniprot id: A0A8J1KVP1
uniprot id: A0A8J1KYP7
uniprot id: Q6GM82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
messages: Homodimer.

8355:hnrnpk.L
gene id: 8355:hnrnpk.L
uniprot id: A0A1L8HYH7
uniprot id: A0A8J0V3R8
uniprot id: A0A8J0V7M7
uniprot id: A0A8J1KSS8
names: Subcellular Location Annotation
messages: nucleoplasm

8355:styx.S
gene id: 8355:styx.S
uniprot id: Q5U593
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Catalytically inactive phosphatase.
messages: Contains a Gly residue instead of a conserved Cys residue at position 120 in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (By similarity). The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and may protect them from phosphatases (By similarity).

8355:npffr1.1.S
gene id: 8355:npffr1.1.S
uniprot id: Q6NTM7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

8355:sema6c.S
gene id: 8355:sema6c.S
uniprot id: A0A1L8F4R8
uniprot id: A0A8J0TQL7
uniprot id: A0A8J1LLI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108697042
gene id: 8355:LOC108697042
uniprot id: A0A1L8FND5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Membrane

8355:or5f1l1.1.L
gene id: 8355:or5f1l1.1.L
uniprot id: A0A8J0UGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:LOC121400780
gene id: 8355:LOC121400780
uniprot id: A0A8J1MGZ4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:dbh.S
gene id: 8355:dbh.S
uniprot id: A0A1L8F0Z4
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

8355:limk2.S
gene id: 8355:limk2.S
uniprot id: A0A8J0U6S0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

8355:glce.S
gene id: 8355:glce.S
uniprot id: A0A1L8GS91
uniprot id: A0A8J0UW59
uniprot id: A0A8J0UZT9
uniprot id: A0A8J1MQT8
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

8355:traf6.S
gene id: 8355:traf6.S
uniprot id: Q3MV19
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Cytoplasm
messages: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.
messages: First detected in the neurula stage and then increased during late tadpole stage.
messages: Highly expressed in ovary and moderately expressed in kidney, spleen, stomach, colon and testis.
messages: Homotrimer (By similarity). Homooligomer (By similarity). Interacts with tifa (PubMed:16023795).
messages: Lipid droplet
messages: Nucleus
messages: The MATH/TRAF domain binds to receptor cytoplasmic domains.
messages: cell cortex

8355:topaz1.L
gene id: 8355:topaz1.L
uniprot id: A0A1L8FWF9
uniprot id: A0A8J0VJ52
uniprot id: A0A8J1KXC6
names: Function
names: Subcellular Location Annotation
messages: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
messages: cytosol

8355:nav3.L
gene id: 8355:nav3.L
uniprot id: A0A8J0UPT3
uniprot id: A0A8J0UU77
uniprot id: A0A8J1MKK9
uniprot id: A0A8J1MKM7
uniprot id: A0A8J1MLF7
uniprot id: A0A8J1MLK8
uniprot id: A0A8J1MMM9
names: Similarity
messages: Belongs to the Nav/unc-53 family.

8355:rhcg.L
gene id: 8355:rhcg.L
uniprot id: A0A1L8H0W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

8355:tdrd6.L
gene id: 8355:tdrd6.L
uniprot id: Q90WE3
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in testis.
messages: Interacts with FRGY2 (a component of messenger ribonucleoprotein (mRNP) particle)during germ cell develpoment.
messages: Loss-of-function in embryos causes arrest of karyokinesis progression.
messages: Presents exclusively in early embryonic and germline cells (PubMed:15771630, PubMed:21314676). Expressed in both spermatogenic and oogenic cells except for round spermatids and the later stage (PubMed:12112575). Expressed in early stage embryos and decrease after the gastrula stage (PubMed:12112575).
messages: The tudor domains recognize and bind to proteins with dimethylated arginine residues.
messages: Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation (By similarity). Component of cytoplasmic mRNP particle through interaction with FRGY2, and binds to maternal mRNA related to cell cycle (RCC1, RHAMM, INCENP-A, MAD2L1, HELLS) and a germ plasm specific mRNA (Dead end/Dnd1), it is proposed a role in translational activation of the maternal mRNAs repressed in mRNP particle (PubMed:21314676).

8355:LOC108701939
gene id: 8355:LOC108701939
uniprot id: A0A8J0TY39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:gabra2.S
gene id: 8355:gabra2.S
uniprot id: Q6AX36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

8355:slc7a10.S
gene id: 8355:slc7a10.S
uniprot id: A0A8J1KLN3
names: Subcellular Location Annotation
messages: Membrane

8355:abhd16a.L
gene id: 8355:abhd16a.L
uniprot id: A0A1L8F8K2
uniprot id: A0A8J1LH19
uniprot id: Q6DCW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

8355:llgl2.S
gene id: 8355:llgl2.S
uniprot id: A0A1L8EMV4
uniprot id: A0A1L8EMX1
uniprot id: Q6GQ24
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

8355:slc6a16.S
gene id: 8355:slc6a16.S
uniprot id: A0A1L8FH11
uniprot id: A0A8J1LEU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:alpi.1.L
gene id: 8355:alpi.1.L
uniprot id: A1L2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

8355:best1.L
gene id: 8355:best1.L
uniprot id: A0A1L8GJ79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

8355:ap1g1.S
gene id: 8355:ap1g1.S
uniprot id: A0A8J1KIB9
uniprot id: A0A8J1KIC3
uniprot id: A0A8J1KK32
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

8355:LOC108709765
gene id: 8355:LOC108709765
uniprot id: A0A1L8H948
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8355:LOC121394742
gene id: 8355:LOC121394742
uniprot id: A0A8J1KYP8
uniprot id: A0A8J1L1J1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:srd5a1.S
gene id: 8355:srd5a1.S
uniprot id: A5D8N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane
messages: Microsome membrane

8355:sec16a.S
gene id: 8355:sec16a.S
uniprot id: A0A1L8F142
uniprot id: A0A8J0TMI3
uniprot id: A0A8J0TNR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.
messages: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.

8355:cybrd1.S
gene id: 8355:cybrd1.S
uniprot id: A0A1L8EP67
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Cell membrane
messages: Homodimer.
messages: Membrane

8355:LOC108703895
gene id: 8355:LOC108703895
uniprot id: A0A8J0U452
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:pkp4.S
gene id: 8355:pkp4.S
uniprot id: A0A8J0TQA4
uniprot id: A0A8J1LVT0
uniprot id: A0A8J1LVT5
uniprot id: A0A8J1LVV4
uniprot id: A0A8J1LW91
uniprot id: A0A8J1LX60
uniprot id: A0A8J1LX66
uniprot id: A0A8J1LY11
uniprot id: A0A8J1LY18
uniprot id: Q8AXM8
names: Similarity
messages: Belongs to the beta-catenin family.

8355:LOC108710624
gene id: 8355:LOC108710624
uniprot id: A0A1L8H262
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108695882
gene id: 8355:LOC108695882
uniprot id: A0A8J0T913
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108706772
gene id: 8355:LOC108706772
uniprot id: A0A1L8HMI2
uniprot id: A0A8J1M1S0
uniprot id: A0A8J1M1S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

8355:sfxn4.L
gene id: 8355:sfxn4.L
uniprot id: A0A8J0TBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

8355:LOC108698781
gene id: 8355:LOC108698781
uniprot id: A0A1L8F9X7
uniprot id: A0A8J0TIE7
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8355:furin.L
gene id: 8355:furin.L
uniprot id: Q5XHG7
names: Similarity
messages: Belongs to the peptidase S8 family.

8355:arhgef12.S
gene id: 8355:arhgef12.S
uniprot id: Q6XS95
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

8355:wdr91.L
gene id: 8355:wdr91.L
uniprot id: A0A8J1MK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

8355:gpr37l1.S
gene id: 8355:gpr37l1.S
uniprot id: A0A1L8H734
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:magi1.S
gene id: 8355:magi1.S
uniprot id: A0A8J1KK68
uniprot id: A0A8J1KK71
uniprot id: A0A8J1KK75
uniprot id: A0A8J1KK76
uniprot id: A0A8J1KK80
uniprot id: A0A8J1KK85
uniprot id: A0A8J1KLV2
uniprot id: A0A8J1KN95
uniprot id: A0A8J1KNA0
names: Subcellular Location Annotation
messages: Membrane

8355:galnt9.S
gene id: 8355:galnt9.S
uniprot id: A0A1L8HQH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108707623
gene id: 8355:LOC108707623
uniprot id: A0A8J1MAK5
uniprot id: A0A8J1MBK8
uniprot id: A0A8J1MCC9
names: Subcellular Location Annotation
messages: Nucleus

8355:hexim1.S
gene id: 8355:hexim1.S
uniprot id: A0A1L8EL14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

8355:isl1.S
gene id: 8355:isl1.S
uniprot id: A0A8J1LF37
uniprot id: A0A8J1LHJ4
uniprot id: A0A8J1LHJ9
uniprot id: Q08B34
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108702164
gene id: 8355:LOC108702164
uniprot id: A0A8J0TZG9
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

8355:clstn2.L
gene id: 8355:clstn2.L
uniprot id: A0A8J1KPV0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Membrane

8355:arglu1.L
gene id: 8355:arglu1.L
uniprot id: A0A1L8HH15
names: Similarity
messages: Belongs to the UPF0430 family.

8355:atp6v0c.S
gene id: 8355:atp6v0c.S
uniprot id: A0A1L8EQQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

8355:ntrk1.L
gene id: 8355:ntrk1.L
uniprot id: A0A1L8FC93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:pde6c.S
gene id: 8355:pde6c.S
uniprot id: A0A1L8FEW4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:LOC108702781
gene id: 8355:LOC108702781
uniprot id: A0A1L8EML9
names: Similarity
messages: Belongs to the IL-17 family.

8355:ppp1r10.S
gene id: 8355:ppp1r10.S
uniprot id: A0A1L8F3R2
uniprot id: Q6GLQ4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable inhibitor of phosphatase activity.

8355:irf8.L
gene id: 8355:irf8.L
uniprot id: Q6DE53
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:nfatc4.L
gene id: 8355:nfatc4.L
uniprot id: A0A1L8HZL8
names: Subcellular Location Annotation
messages: Nucleus

8355:ppp2r2d.S
gene id: 8355:ppp2r2d.S
uniprot id: Q7ZX64
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing ppp2r2d (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ensa and arpp19 inhibitors. PP2A complexes containing ppp2r2d (PR55-delta) also regulate the activity of TGF-beta/Activin/Nodal signaling by restricting receptor activity. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment.
messages: Belongs to the phosphatase 2A regulatory subunit B family.
messages: Cytoplasm
messages: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ensa (when phosphorylated at 'Ser-67') and arpp19 (when phosphorylated at 'Ser-67'), leading to inhibit PP2A activity.
messages: ppp2r2d is an abundant subunit in egg extracts and represents 70% or more of B55 subunits.

8355:slc25a29.L
gene id: 8355:slc25a29.L
uniprot id: A0A1L8FA24
uniprot id: Q66KI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:ngb.L
gene id: 8355:ngb.L
uniprot id: A0A1L8F9A9
uniprot id: A0A8J0TKD8
names: Similarity
messages: Belongs to the globin family.

8355:LOC121393092
gene id: 8355:LOC121393092
uniprot id: A0A8J1KQV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

8355:nol6.L
gene id: 8355:nol6.L
uniprot id: Q6NRY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NRAP family.
messages: Interacts with RRP7A; required for NOL6 localization to nucleolus.
messages: Probably associated with rRNA.
messages: nucleolus

8355:mgrn1.S
gene id: 8355:mgrn1.S
uniprot id: A0A8J0TW99
uniprot id: Q6P7J2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

8355:tspan31.L
gene id: 8355:tspan31.L
uniprot id: Q7ZWW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:gbp4.S
gene id: 8355:gbp4.S
uniprot id: A0A1L8ERF5
uniprot id: Q6PCI2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:cdh3.L
gene id: 8355:cdh3.L
uniprot id: A0A1L8GKW6
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

8355:sult1c1.L
gene id: 8355:sult1c1.L
uniprot id: Q7ZYH0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:slc6a13.L
gene id: 8355:slc6a13.L
uniprot id: Q6PA82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:LOC108716156
gene id: 8355:LOC108716156
uniprot id: A0A1L8G8Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

8355:eppk1.S
gene id: 8355:eppk1.S
uniprot id: A0A8J0T5D7
names: Subcellular Location Annotation
messages: cytoskeleton

8355:slc26a5.L
gene id: 8355:slc26a5.L
uniprot id: A0A1L8GZ86
uniprot id: A0A8J0URG2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:rraga.S
gene id: 8355:rraga.S
uniprot id: Q6IP38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

8355:fermt1.S
gene id: 8355:fermt1.S
uniprot id: Q7ZYR0
names: Similarity
messages: Belongs to the kindlin family.

8355:LOC108703951
gene id: 8355:LOC108703951
uniprot id: A0A8J0TVQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

8355:slc39a1.L
gene id: 8355:slc39a1.L
uniprot id: A0A1L8FDA8
names: Subcellular Location Annotation
messages: Membrane

8355:ppp1r2.S
gene id: 8355:ppp1r2.S
uniprot id: A0A1L8G3Y6
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

8355:rhbdd2.L
gene id: 8355:rhbdd2.L
uniprot id: A0A1L8HFY8
uniprot id: A0A8J0UE21
names: Subcellular Location Annotation
messages: Membrane

8355:pcnp.S
gene id: 8355:pcnp.S
uniprot id: A0A1L8H8E7
uniprot id: A0A8J0UL10
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

8355:hectd1.S
gene id: 8355:hectd1.S
uniprot id: A0A1L8EZI0
uniprot id: A0A8J0TLL4
uniprot id: A0A8J0TNT1
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

8355:LOC108699056
gene id: 8355:LOC108699056
uniprot id: A0A1L8FBN2
names: Subcellular Location Annotation
messages: Membrane

8355:prune1.L
gene id: 8355:prune1.L
uniprot id: A0A8J1LJ41
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

8355:acaa1.L
gene id: 8355:acaa1.L
uniprot id: Q7SYR2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

8355:znf706.L
gene id: 8355:znf706.L
uniprot id: Q6DE65
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:LOC121394482
gene id: 8355:LOC121394482
uniprot id: A0A8J1KZ86
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:ppp1cc.L
gene id: 8355:ppp1cc.L
uniprot id: P36874
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cleavage furrow
messages: Cytoplasm
messages: Membrane
messages: Midbody
messages: Mitochondrion
messages: Nucleus
messages: Nucleus speckle
messages: PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits.
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (By similarity). Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin.
messages: kinetochore
messages: nucleolus
messages: nucleoplasm

8355:flot1.S
gene id: 8355:flot1.S
uniprot id: A0A8J0TME9
uniprot id: Q8AWZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane

8355:adcy3.L
gene id: 8355:adcy3.L
uniprot id: A0A1L8GC45
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

8355:ydjc.S
gene id: 8355:ydjc.S
uniprot id: A0A1L8HQE0
uniprot id: A0A8J1M3G3
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

8355:serpini1.S
gene id: 8355:serpini1.S
uniprot id: Q6GLT7
names: Similarity
messages: Belongs to the serpin family.

8355:purb.S
gene id: 8355:purb.S
uniprot id: Q8AVS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: May bind repeated elements in single-stranded DNA and may participate in transcriptional and translational gene regulation.
messages: Nucleus

8355:atp2a1.L
gene id: 8355:atp2a1.L
uniprot id: A0A8J1LR57
uniprot id: A0A8J1LSE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8355:sult6b1.1.L
gene id: 8355:sult6b1.1.L
uniprot id: Q0IH61
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:LOC121396403
gene id: 8355:LOC121396403
uniprot id: A0A8J1LCF7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:agl.S
gene id: 8355:agl.S
uniprot id: A0A1L8GGF7
uniprot id: A0A8J1KML0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

8355:smad4.2.L
gene id: 8355:smad4.2.L
uniprot id: A0A8J1LGV7
uniprot id: Q9PWJ9
uniprot id: Q9YGP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8355:tet2.S
gene id: 8355:tet2.S
uniprot id: A0A1L8HM87
uniprot id: A0A8J0U8H1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

8355:pla2g12a.S
gene id: 8355:pla2g12a.S
uniprot id: Q6GQC0
names: Subcellular Location Annotation
messages: Secreted

8355:nt5dc2.L
gene id: 8355:nt5dc2.L
uniprot id: A0A8J0PQ66
uniprot id: Q7ZWR5
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

8355:npr3.L
gene id: 8355:npr3.L
uniprot id: A0A8J0U0D9
uniprot id: A0A8J0U8Q0
uniprot id: A0A8J0UB22
uniprot id: Q9DG04
names: Subcellular Location Annotation
messages: Membrane

8355:XB5780651.S
gene id: 8355:XB5780651.S
uniprot id: A0A8J0ULZ2
names: Subcellular Location Annotation
messages: Membrane

8355:plppr3.L
gene id: 8355:plppr3.L
uniprot id: A0A1L8HWJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

8355:khdrbs1.S
gene id: 8355:khdrbs1.S
uniprot id: A0A1L8H7T6
names: Similarity
messages: Belongs to the KHDRBS family.

8355:LOC108702612
gene id: 8355:LOC108702612
uniprot id: A0A1L8ELF3
uniprot id: A0A1L8ELK1
uniprot id: A0A8J0TRU0
uniprot id: A0A8J0U0D5
names: Similarity
messages: Belongs to the AP-2 family.

8355:cul9.L
gene id: 8355:cul9.L
uniprot id: A0A8J0V9T8
uniprot id: A0A8J0VB52
uniprot id: A0A8J1KMK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

8355:htr1a.L
gene id: 8355:htr1a.L
uniprot id: Q98998
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
messages: Cell membrane
messages: First expressed in the rostral part of the brain stem at stage 22. At later stages of development, expression is localized to serotonergic neurons. The expression pattern changes in the tadpole of stage 41 where, in addition to serotonergic neurons, expression is also localized to the inner nuclear layer (INL) of the developing retina. This expression pattern continues through to the start of metamorphosis (stage 46). In adults, expressed in the brain, in particular the telencephalon, diencephalon and mesencephalon. In the telencephalic region, expression is localized to the lateral, dorsal and medial pallium, and in the striatum, septum and amygdala. In the mesencephalic region, expression is strongest in the optic tectum and torus semicircularis with moderate levels of expression in tegmental nuclei. In diencephalon, localized to the dorsal and ventral thalamus and the preoptic area of the hypothalamus.
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity and behavior. Activation of the receptor may play a role in the exit from G0 phase and in promoting DNA synthesis.
messages: dendrite

8355:slc26a5.S
gene id: 8355:slc26a5.S
uniprot id: A0A1L8GTW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:gtf2h4.S
gene id: 8355:gtf2h4.S
uniprot id: A0A8J0UGU2
uniprot id: Q6INF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

8355:LOC108718213
gene id: 8355:LOC108718213
uniprot id: A0A8J1KUF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:fam13c.S
gene id: 8355:fam13c.S
uniprot id: A0A8J0TED6
names: Similarity
messages: Belongs to the FAM13 family.

8355:XB5894820.L
gene id: 8355:XB5894820.L
uniprot id: A9UM08
names: Similarity
messages: Belongs to the HEBP family.

8355:osgepl1.L
gene id: 8355:osgepl1.L
uniprot id: A0A1L8EX61
uniprot id: A0A8J0TWT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Mitochondrion
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

8355:ola1.L
gene id: 8355:ola1.L
uniprot id: Q7ZWM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

8355:cul5.S
gene id: 8355:cul5.S
uniprot id: A0A1L8HAU2
uniprot id: A0A8J0UMA4
uniprot id: A0A8J1MFK5
uniprot id: A0A8J1MGI8
names: Similarity
messages: Belongs to the cullin family.

8355:prelid3a.L
gene id: 8355:prelid3a.L
uniprot id: Q6GM21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the slowmo family.
messages: In vitro, the triap1:prelid3a complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.
messages: Interacts with triap1.
messages: Mitochondrion

8355:tmprss2.10.L
gene id: 8355:tmprss2.10.L
uniprot id: A0A8J1M718
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ndufa6.S
gene id: 8355:ndufa6.S
uniprot id: Q5HZN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8355:LOC108710431
gene id: 8355:LOC108710431
uniprot id: A0A8J1MJD1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:slc6a8.S
gene id: 8355:slc6a8.S
uniprot id: A0A1L8F1J9
uniprot id: A0A8J0TMY2
uniprot id: A0A8J1LNY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:XB5832479.L
gene id: 8355:XB5832479.L
uniprot id: A0A1L8FJF3
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

8355:ttr.L
gene id: 8355:ttr.L
uniprot id: A0A8J1KY98
uniprot id: B7ZS96
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A number of compounds can compete with and disrupt triiodothyronine (T3)-binding. Binds the synthetic estrogen diethylstilbestrol (DES) with the same affinity as T3. Phenolic and phenol compounds can also disrupt T3-binding, with brominated derivatives of bisphenol A (e.g. 3,3'5-tribromobisphenol A) having a higher binding affinity than the chlorinated derivatives (e.g. 3,3'5-trichlorobisphenol A), but with the bromophenols showing lower binding affinity than the chlorophenols.
messages: Belongs to the transthyretin family.
messages: Detected in plasma (at protein level). Expressed during metamorphosis in tadpole liver, but not in tadpole brain nor adult liver. Between 1.5 and 3 days of development, also expressed in the mesoderm of the kidney.
messages: Expressed in tadpoles from premetamorphic stage 53 until the end of prometamorphic stage 60. Expression levels reach a maximum at prometamorphic stages 58 to 59, then decline gradually during metamorphic climax stages (61-66). Undetectable in adults.
messages: Homotetramer.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with rbp4.
messages: Secreted
messages: The N-terminus strongly influences thyroid hormone-binding properties.
messages: The estrogen ethinylestradiol (EE2) significantly decreases expression in both male and female livers. The environmental contaminants polychlorinated biphenyls (PCBs) result in an increase in gene expression and a delay in metamorphosis.
messages: Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4). Probably transports triiodothyronine from the bloodstream to the brain.
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

8355:sfr1.L
gene id: 8355:sfr1.L
uniprot id: A0A1L8FJ76
uniprot id: Q68F53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SFR1/MEI5 family.
messages: Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination (By similarity).
messages: Component of the swi5-sfr1 complex.
messages: Nucleus

8355:h2ac7.L
gene id: 8355:h2ac7.L
uniprot id: Q6AZS1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108707463
gene id: 8355:LOC108707463
uniprot id: A0A1L8HE04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121399407
gene id: 8355:LOC121399407
uniprot id: A0A8J1M2P7
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:grk5l.S
gene id: 8355:grk5l.S
uniprot id: A0A1L8GRG1
uniprot id: A0A8J0UUN6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:ppp1r26.L
gene id: 8355:ppp1r26.L
uniprot id: Q6NU19
names: Function
names: Subcellular Location Annotation
messages: May inhibit phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation (By similarity).
messages: nucleolus

8355:rpl6.S
gene id: 8355:rpl6.S
uniprot id: A0A8J0TXA4
uniprot id: A0A8J0TXB0
uniprot id: A0A8J0U088
uniprot id: Q6DJF7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

8355:LOC108700827
gene id: 8355:LOC108700827
uniprot id: A0A1L8ES96
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:adra2b.S
gene id: 8355:adra2b.S
uniprot id: A0A1L8GS17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:mrps15.L
gene id: 8355:mrps15.L
uniprot id: A0A1L8HFJ1
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

8355:LOC121402926
gene id: 8355:LOC121402926
uniprot id: A0A8J1MXP6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108709852
gene id: 8355:LOC108709852
uniprot id: A0A8J0ULR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8355:echdc3.L
gene id: 8355:echdc3.L
uniprot id: A9JS71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: May play a role in fatty acid biosynthesis and insulin sensitivity.
messages: Mitochondrion

8355:LOC108710454
gene id: 8355:LOC108710454
uniprot id: A0A8J1MIQ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cd93.L
gene id: 8355:cd93.L
uniprot id: A0A1L8G5Q4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:toe1.L
gene id: 8355:toe1.L
uniprot id: A0A1L8GM42
names: Similarity
messages: Belongs to the CAF1 family.

8355:dpysl5.S
gene id: 8355:dpysl5.S
uniprot id: A0A1L8G5R4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

8355:csrnp2.S
gene id: 8355:csrnp2.S
uniprot id: A0A8J1MGM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

8355:LOC121393813
gene id: 8355:LOC121393813
uniprot id: A0A8J1KPU4
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

8355:LOC108699795
gene id: 8355:LOC108699795
uniprot id: A0A1L8F052
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:rbpj.L
gene id: 8355:rbpj.L
uniprot id: A0A1L8HTS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

8355:narf.L
gene id: 8355:narf.L
uniprot id: A0A8J1LPT6
uniprot id: Q6GP25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NARF family.
messages: Nucleus

8355:brpf1.S
gene id: 8355:brpf1.S
uniprot id: A0A1L8GHU6
names: Subcellular Location Annotation
messages: Nucleus

8355:prrt1.L
gene id: 8355:prrt1.L
uniprot id: A0A1L8F8D5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:LOC108712617
gene id: 8355:LOC108712617
uniprot id: A0A1L8HWI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

8355:LOC121401357
gene id: 8355:LOC121401357
uniprot id: A0A8J1MJT1
names: Subcellular Location Annotation
messages: Membrane

8355:ankrd34b.L
gene id: 8355:ankrd34b.L
uniprot id: A0A1L8I1Z9
uniprot id: Q5PQ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKRD34 family.
messages: Cytoplasm
messages: Nucleus

8355:aldh8a1.L
gene id: 8355:aldh8a1.L
uniprot id: A0A8J1KQ75
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8355:uvssa.L
gene id: 8355:uvssa.L
uniprot id: A0A1L8HT08
names: Similarity
messages: Belongs to the UVSSA family.

8355:chit1.S
gene id: 8355:chit1.S
uniprot id: Q6GP67
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

8355:LOC108707995
gene id: 8355:LOC108707995
uniprot id: A0A1L8HDG4
uniprot id: A0A8J0UCT0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8355:LOC121403738
gene id: 8355:LOC121403738
uniprot id: A0A8J1N226
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

8355:LOC121402015
gene id: 8355:LOC121402015
uniprot id: A0A1L8HT63
names: Subcellular Location Annotation
messages: Secreted

8355:mcur1.L
gene id: 8355:mcur1.L
uniprot id: B1H1R0
names: Similarity
messages: Belongs to the CCDC90 family.

8355:p4ha2.L
gene id: 8355:p4ha2.L
uniprot id: A0A8J0UNS3
uniprot id: Q66J10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8355:LOC121401358
gene id: 8355:LOC121401358
uniprot id: A0A8J1MJ32
uniprot id: A0A8J1ML46
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108711262
gene id: 8355:LOC108711262
uniprot id: A0A8J1MM76
uniprot id: A0A8J1MND7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Postsynaptic density

8355:epgn.S
gene id: 8355:epgn.S
uniprot id: A0A1L8HMI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108698993
gene id: 8355:LOC108698993
uniprot id: A0A8J0TLA6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:bckdha.L
gene id: 8355:bckdha.L
uniprot id: A0A1L8F8Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

8355:LOC121401313
gene id: 8355:LOC121401313
uniprot id: A0A8J1MJQ9
names: Subcellular Location Annotation
messages: Membrane

8355:cyp21a2.1.L
gene id: 8355:cyp21a2.1.L
uniprot id: Q6AX26
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108717222
gene id: 8355:LOC108717222
uniprot id: A0A8J0V9Q1
uniprot id: A0A8J0VCL1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

8355:mipep.L
gene id: 8355:mipep.L
uniprot id: A0A1L8HJ35
uniprot id: A0A8J0UH51
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

8355:LOC121393565
gene id: 8355:LOC121393565
uniprot id: A0A8J1KLX7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:dnaja1.S
gene id: 8355:dnaja1.S
uniprot id: A0A1L8HMY1
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108705352
gene id: 8355:LOC108705352
uniprot id: A0A8J1N148
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108703559
gene id: 8355:LOC108703559
uniprot id: A0A8J1MT25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

8355:slc35b1.L
gene id: 8355:slc35b1.L
uniprot id: A0A8J1LQU1
uniprot id: Q6GQ70
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable sugar transporter.
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

8355:LOC121394353
gene id: 8355:LOC121394353
uniprot id: A0A8J1KWG7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:hmgb2.S
gene id: 8355:hmgb2.S
uniprot id: Q32NS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

8355:rxra.S
gene id: 8355:rxra.S
uniprot id: A0A1L8F189
uniprot id: A0A8J0TG25
uniprot id: A0A8J0TNS6
uniprot id: A0A8J0TPQ4
uniprot id: A0A8J1LNW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

8355:phyhip.S
gene id: 8355:phyhip.S
uniprot id: A0A8J0UUR8
names: Similarity
messages: Belongs to the PHYHIP family.

8355:ccdc85c.L
gene id: 8355:ccdc85c.L
uniprot id: A0A8J0U5N2
uniprot id: A0A8J1LHG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

8355:LOC108700035
gene id: 8355:LOC108700035
uniprot id: A0A8J0TGM2
uniprot id: A0A8J0TQA1
uniprot id: A0A8J0TRB9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:cycs.S
gene id: 8355:cycs.S
uniprot id: Q6DKE1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Mitochondrion intermembrane space

8355:ndufa1.L
gene id: 8355:ndufa1.L
uniprot id: A0A1L8F7N1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Mitochondrion inner membrane

8355:dync1li1.L
gene id: 8355:dync1li1.L
uniprot id: Q7ZXE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

8355:pcbd2.L
gene id: 8355:pcbd2.L
uniprot id: A0A8J0PUH7
uniprot id: Q6NU70
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

8355:LOC495950
gene id: 8355:LOC495950
uniprot id: Q5PQ85
names: Subcellular Location Annotation
messages: Golgi apparatus membrane

8355:LOC108697688
gene id: 8355:LOC108697688
uniprot id: A0A1L8FGH6
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

8355:cdca5.S
gene id: 8355:cdca5.S
uniprot id: A0A8J0V071
uniprot id: B7ZPV2
uniprot id: Q563C3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sororin family.
messages: Chromosome
messages: Cytoplasm
messages: Interacts with the APC/C complex. Interacts with the chromatin-bound cohesin complex; the interaction is indirect, occurs after DNA replication and requires acetylation of the cohesin component smc3. Interacts (via the FGF motif) with pds5a and pds5b; the interaction is direct and prevents the interaction of pds5a with wapl (Probable).
messages: Nucleus
messages: Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of wapl which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair (Probable).
messages: The KEN box is required for the association with the APC/C complex.
messages: Ubiquitinated by the APC/C complex in G1, leading to its degradation.

8355:cryga.6.L
gene id: 8355:cryga.6.L
uniprot id: A0A8J0TY08
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:mpv17.L
gene id: 8355:mpv17.L
uniprot id: A0A8J1KQP0
uniprot id: A0A8J1KQP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

8355:LOC108712256
gene id: 8355:LOC108712256
uniprot id: A0A8J1MPY1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:alkbh8.S
gene id: 8355:alkbh8.S
uniprot id: A0A1L8HAY4
uniprot id: A0A8J0UEA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

8355:MGC84007
gene id: 8355:MGC84007
uniprot id: Q6GM34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

8355:LOC398398
gene id: 8355:LOC398398
uniprot id: Q5EAY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8355:LOC108714430
gene id: 8355:LOC108714430
uniprot id: A0A1L8GN69
uniprot id: A0A8J0UXJ3
uniprot id: A0A8J1MXK1
uniprot id: A0A8J1MYG6
uniprot id: A0A8J1MZT2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:wtip.L
gene id: 8355:wtip.L
uniprot id: A9LS46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zyxin/ajuba family.
messages: Interacts with prickle3 (PubMed:27062996).
messages: May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development. Involved in the organization of the basal body (PubMed:27062996). Involved in cilia growth and positioning (PubMed:27062996).
messages: Nucleus
messages: adherens junction

8355:htr2c.L
gene id: 8355:htr2c.L
uniprot id: A0A1L8F7W0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MPDZ. Interacts with ARRB2.
messages: Membrane

8355:lyg2.S
gene id: 8355:lyg2.S
uniprot id: Q5XK71
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

8355:irf1.L
gene id: 8355:irf1.L
uniprot id: Q6PB00
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:jup.S
gene id: 8355:jup.S
uniprot id: A0A8J0TYX1
uniprot id: P30998
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-catenin family.
messages: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.
messages: Homodimer.
messages: Membrane
messages: adherens junction
messages: cytoskeleton
messages: desmosome

8355:LOC108702439
gene id: 8355:LOC108702439
uniprot id: A0A1L8ERB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:c1orf74.L
gene id: 8355:c1orf74.L
uniprot id: Q5PQ92
names: Similarity
messages: Belongs to the UPF0739 family.

8355:agpat2.S
gene id: 8355:agpat2.S
uniprot id: A0A1L8F126
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

8355:nkx3-3.L
gene id: 8355:nkx3-3.L
uniprot id: A0A1L8FJH8
names: Subcellular Location Annotation
messages: Nucleus

8355:ube2c.S
gene id: 8355:ube2c.S
uniprot id: Q5I005
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:adhfe1.S
gene id: 8355:adhfe1.S
uniprot id: A0A1L8FT50
uniprot id: A0A8J0VPQ7
uniprot id: Q08B39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).
messages: Mitochondrion

8355:dnah14.L
gene id: 8355:dnah14.L
uniprot id: A0A1L8G673
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:ctc1.S
gene id: 8355:ctc1.S
uniprot id: E7FLL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

8355:timm10b.S
gene id: 8355:timm10b.S
uniprot id: Q6GR66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force.
messages: Component of the TIM22 complex.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of timm10b from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.

8355:LOC108716560
gene id: 8355:LOC108716560
uniprot id: A0A8J0VFD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

8355:LOC108704404
gene id: 8355:LOC108704404
uniprot id: A0A8J0U3X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:LOC108709836
gene id: 8355:LOC108709836
uniprot id: A0A8J0UKA8
uniprot id: A0A8J0ULL9
names: Similarity
messages: Belongs to the TGF-beta family.

8355:atp6v0b.L
gene id: 8355:atp6v0b.L
uniprot id: Q66IW6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

8355:rpl11.L
gene id: 8355:rpl11.L
uniprot id: A0A1L8HFU5
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

8355:pknox1.S
gene id: 8355:pknox1.S
uniprot id: A0A1L8H5S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

8355:myo1h.L
gene id: 8355:myo1h.L
uniprot id: A0A8J0V7N1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:myog.S
gene id: 8355:myog.S
uniprot id: Q8UUX7
names: Subcellular Location Annotation
messages: Nucleus

8355:dynlt4.S
gene id: 8355:dynlt4.S
uniprot id: A0A1L8GFN9
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8355:arg2.L
gene id: 8355:arg2.L
uniprot id: A1A614
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Homotrimer.

8355:nipal1.L
gene id: 8355:nipal1.L
uniprot id: A0A1L8HTP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

8355:ccn1l.S
gene id: 8355:ccn1l.S
uniprot id: A9UMN6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:rgmb.L
gene id: 8355:rgmb.L
uniprot id: A0A8J0VJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8355:srpk2l.L
gene id: 8355:srpk2l.L
uniprot id: A0A1L8GCP2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:toe1.S
gene id: 8355:toe1.S
uniprot id: A0A1L8GFN0
names: Similarity
messages: Belongs to the CAF1 family.

8355:LOC108702270
gene id: 8355:LOC108702270
uniprot id: A0A8J0TZK1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

8355:olfm3.L
gene id: 8355:olfm3.L
uniprot id: A0A1L8GN76
uniprot id: A0A8J1MV21
uniprot id: Q642R1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

8355:KEF37 p05
gene id: 8355:KEF37_p05
uniprot id: P03904
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Mitochondrion inner membrane

8355:scgn.S
gene id: 8355:scgn.S
uniprot id: A0A1L8FSI7
names: Subcellular Location Annotation
messages: Cytoplasm

8355:npy.L
gene id: 8355:npy.L
uniprot id: P33689
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
messages: Secreted
messages: neuronal dense core vesicle

8355:LOC121402057
gene id: 8355:LOC121402057
uniprot id: A0A8J1MPQ0
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108713296
gene id: 8355:LOC108713296
uniprot id: A0A8J1MTB2
uniprot id: A0A8J1MUK8
names: Subcellular Location Annotation
messages: Cytoplasm

8355:melk.L
gene id: 8355:melk.L
uniprot id: Q91821
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Activated by autophosphorylation of the T-loop at Thr-169 and Ser-173: in contrast to other members of the SNF1 subfamily, phosphorylation at Thr-169 is not mediated by STK11/LKB1 but via autophosphorylation instead.
messages: Autophosphorylated: autophosphorylation of the T-loop at Thr-169 and Ser-173 is required for activation (By similarity). Phosphorylated by the maturation promoting factor (MPF), composed of cdk1 and a cyclin-B. Also phosphorylated by some MAPK. Phosphorylated during oocyte maturation. Dephosphorylation destabilizes the protein. There is some ambiguity for some phosphosites: Thr-481/Thr-483 and Ser-505/Ser-517.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cell membrane
messages: Contaminating sequence. Potential poly-A sequence.
messages: Degraded when cells exit mitosis.
messages: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis (By similarity). Plays a role in cytokinesis during early development.
messages: The KA1 domain mediates binding to phospholipids and targeting to membranes.

8355:LOC108706827
gene id: 8355:LOC108706827
uniprot id: Q92140
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

8355:pdia3.L
gene id: 8355:pdia3.L
uniprot id: A0A1L8H0R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

8355:med8.S
gene id: 8355:med8.S
uniprot id: Q6DD30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: Component of the Mediator complex. May be part of a multisubunit E3 ubiquitin-protein ligase complex (By similarity).
messages: Nucleus

8355:cyria.L
gene id: 8355:cyria.L
uniprot id: A0A1L8GBL6
uniprot id: A0A8J0V9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

8355:pld1.L
gene id: 8355:pld1.L
uniprot id: A0A8J1KP10
uniprot id: Q6DED6
names: Similarity
messages: Belongs to the phospholipase D family.

8355:puf60.L
gene id: 8355:puf60.L
uniprot id: A0A8J0VKP7
uniprot id: A0A8J0VLT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

8355:sppl2b.L
gene id: 8355:sppl2b.L
uniprot id: A0A1L8HW08
uniprot id: A0A8J1KHT9
uniprot id: A0A8J1KHU4
uniprot id: A0A8J1KHU8
uniprot id: A0A8J1KL04
uniprot id: A0A8J1KL13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

8355:LOC121396458
gene id: 8355:LOC121396458
uniprot id: A0A8J1LF57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

8355:LOC108715161
gene id: 8355:LOC108715161
uniprot id: A2BD76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

8355:psma3.L
gene id: 8355:psma3.L
uniprot id: Q8AVD2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

8355:apoa5.L
gene id: 8355:apoa5.L
uniprot id: A8E611
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

8355:LOC108700578
gene id: 8355:LOC108700578
uniprot id: A0A8J1LNX0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:pgpep1.S
gene id: 8355:pgpep1.S
uniprot id: Q3KQ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

8355:b3gnt3.2.S
gene id: 8355:b3gnt3.2.S
uniprot id: A0A8J0TV53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC108705931
gene id: 8355:LOC108705931
uniprot id: A0A8J1MLR8
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:tmem184b.L
gene id: 8355:tmem184b.L
uniprot id: A0A1L8GNU3
uniprot id: A0A1L8GP03
uniprot id: A0A8J1MUN1
uniprot id: A0A8J1MUZ7
uniprot id: Q6NU57
names: Subcellular Location Annotation
messages: Membrane

8355:hmgn3.S
gene id: 8355:hmgn3.S
uniprot id: A0A8J0VA22
uniprot id: A0A8J0VCY2
uniprot id: A0A8J0VDC7
uniprot id: Q7SZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

8355:phf23l.L
gene id: 8355:phf23l.L
uniprot id: Q0IHB0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of autophagy.
messages: Belongs to the PHF23 family.
messages: Cytoplasm
messages: Nucleus
messages: The PHD-type zinc-finger domain is required for negative regulation of autophagy.

8355:gapdh.S
gene id: 8355:gapdh.S
uniprot id: P51469
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
messages: Homotetramer.
messages: Nucleus
messages: S-nitrosylation of Cys-150 leads to translocation to the nucleus.
messages: cytoskeleton
messages: cytosol

8355:cad.L
gene id: 8355:cad.L
uniprot id: A0A1L8GD17
uniprot id: A0A8J0V5P7
uniprot id: A0A8J1KQN7
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

8355:scd.L
gene id: 8355:scd.L
uniprot id: A2RRT2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

8355:rhag.L
gene id: 8355:rhag.L
uniprot id: A0A1L8GCE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

8355:ntf2
gene id: 8355:ntf2
uniprot id: O42242
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).
messages: Homodimer.

8355:LOC121398895
gene id: 8355:LOC121398895
uniprot id: A0A8J1LZA7
names: Similarity
messages: Belongs to the cyclin family.

8355:slc37a1.S
gene id: 8355:slc37a1.S
uniprot id: Q6NTN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

8355:slc47a2.S
gene id: 8355:slc47a2.S
uniprot id: A0A1L8F0S1
uniprot id: A0A8J1LNU8
uniprot id: A0A8J1LPU8
uniprot id: A0A8J1LRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

8355:serpind1.S
gene id: 8355:serpind1.S
uniprot id: Q4KLF2
names: Similarity
messages: Belongs to the serpin family.

8355:neu3.1.S
gene id: 8355:neu3.1.S
uniprot id: A0A8J1MHM1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

8355:psmc2.S
gene id: 8355:psmc2.S
uniprot id: A0A1L8GTU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

8355:amelx.L
gene id: 8355:amelx.L
uniprot id: Q9YHT6
names: Similarity
messages: Belongs to the amelogenin family.

8355:rnf40.S
gene id: 8355:rnf40.S
uniprot id: A0A1L8ER50
uniprot id: A0A8J0TU64
uniprot id: A0A8J0U1F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

8355:gps1.L
gene id: 8355:gps1.L
uniprot id: A0A8J0TQZ8
uniprot id: Q6NRT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN1 family.
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Nucleus

8355:gtf2ird1.L
gene id: 8355:gtf2ird1.L
uniprot id: A0A1L8HG89
uniprot id: A0A8J1M923
uniprot id: A0A8J1MA35
uniprot id: A0A8J1MAV9
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108701116
gene id: 8355:LOC108701116
uniprot id: A0A8J1LSX7
uniprot id: A0A8J1LUC8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:LOC121397334
gene id: 8355:LOC121397334
uniprot id: A0A1L8FBY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cdk5r1l.L
gene id: 8355:cdk5r1l.L
uniprot id: A0A1L8FUS4
names: Similarity
messages: Belongs to the cyclin-dependent kinase 5 activator family.

8355:akr1c8p.S
gene id: 8355:akr1c8p.S
uniprot id: Q7SZ92
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8355:aplnr.S
gene id: 8355:aplnr.S
uniprot id: Q2TAD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in all blood vessels including the posterior cardinal vein, intersomitic veins and the vitelline vein network.
messages: Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:17412318). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (By similarity). Promotes angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). May promote sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Required for cardiovascular development, particularly for intersomitic vein angiogenesis by acting as a receptor for apln hormone (PubMed:17412318). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure. Acts upstream of the i/o type of G-alpha proteins in the differentiation of endothelium, erythroid cells, myeloid cells and cardiomyocytes (By similarity).

8355:LOC108695911
gene id: 8355:LOC108695911
uniprot id: A0A1L8FNK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:nlk.S
gene id: 8355:nlk.S
uniprot id: A0A1L8H5Z7
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

8355:frrs1.L
gene id: 8355:frrs1.L
uniprot id: A0A1L8GMP7
uniprot id: Q6INU7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Binds 2 heme b groups non-covalently.
messages: Membrane
messages: Putative ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.
messages: The cytochrome b561 domain lacks the conserved His residue that binds iron in the heme. The reductase activity is therefore unsure in vivo.

8355:cenpv.S
gene id: 8355:cenpv.S
uniprot id: A0A1L8H4X3
names: Similarity
messages: Belongs to the Gfa family.

8355:ugt1a1.L
gene id: 8355:ugt1a1.L
uniprot id: A0A8J0TV95
uniprot id: A0A8J0TWF1
uniprot id: A0A8J0TXU2
uniprot id: A0A8J1LTS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8355:galr2.S
gene id: 8355:galr2.S
uniprot id: A0A1L8EMW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:lancl3.S
gene id: 8355:lancl3.S
uniprot id: A0A1L8H8K0
names: Similarity
messages: Belongs to the LanC-like protein family.

8355:LOC108709195
gene id: 8355:LOC108709195
uniprot id: A0A1L8H4Y9
uniprot id: A0A8J0UJ50
uniprot id: A0A8J1MD55
uniprot id: A0A8J1MDX3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

8355:crybg1.L
gene id: 8355:crybg1.L
uniprot id: A0A1L8G8X1
uniprot id: A0A8J0V827
uniprot id: A0A8J0VB17
uniprot id: A0A8J1KRS8
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:elf5l.L
gene id: 8355:elf5l.L
uniprot id: A0A1L8FN85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:gkap1.L
gene id: 8355:gkap1.L
uniprot id: A0A310TMK0
uniprot id: Q6GNQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GKAP1 family.
messages: Golgi apparatus
messages: May play a role in the regulation of insulin-dependent IRS1 tyrosine phosphorylation in adipocytes.

8355:isca2.L
gene id: 8355:isca2.L
uniprot id: A0A1L8F9A7
uniprot id: A0A8J0TLA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

8355:rab11fip3.S
gene id: 8355:rab11fip3.S
uniprot id: A0A1L8EQS1
uniprot id: A0A8J0U2F0
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

8355:sec61g.S
gene id: 8355:sec61g.S
uniprot id: A0A1L8FWK5
uniprot id: Q66KU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma (By similarity). Component of the ribosome-associated ER translocon complex (By similarity).
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum and multi-pass membrane protein biogenesis.

8355:dcp2.L
gene id: 8355:dcp2.L
uniprot id: A0A8J0UC63
uniprot id: A0A8J0UN20
uniprot id: A0A8J1MBK9
uniprot id: Q45NB9
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

8355:mrps18b.S
gene id: 8355:mrps18b.S
uniprot id: Q3KQG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

8355:sqstm1.L
gene id: 8355:sqstm1.L
uniprot id: Q6PGS1
names: Subcellular Location Annotation
messages: autophagosome

8355:tppp3.L
gene id: 8355:tppp3.L
uniprot id: A0A8J1MWK3
uniprot id: Q2VPM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: Cytoplasm
messages: Regulator of microtubule dynamic that has microtubule bundling activity.
messages: cytoskeleton

8355:tmem144.L
gene id: 8355:tmem144.L
uniprot id: A0A1L8HUB4
uniprot id: A0A8J0UES0
uniprot id: A8E5Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

8355:ddx51.L
gene id: 8355:ddx51.L
uniprot id: B1H1U3
names: Similarity
messages: Belongs to the DEAD box helicase family.

8355:nup58.S
gene id: 8355:nup58.S
uniprot id: Q5EAX5
names: Subcellular Location Annotation
messages: nuclear pore complex

8355:ndrg4.L
gene id: 8355:ndrg4.L
uniprot id: A0A1L8GLH2
uniprot id: A0A8J0UTB7
uniprot id: A0A8J0UTC2
uniprot id: A0A8J0UY93
uniprot id: A0A8J0UY97
uniprot id: A0A8J0UZH2
uniprot id: A0A8J0V356
uniprot id: Q6DJD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the maintenance of intracerebral BDNF levels within the normal range. May enhance growth factor-induced ERK1 and ERK2 phosphorylation. May attenuate growth factor-promoted ELK1 phosphorylation in a microtubule-dependent manner (By similarity).
messages: cytosol

8355:aasdh.L
gene id: 8355:aasdh.L
uniprot id: A0A1L8HTW3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:rpgrip1.L
gene id: 8355:rpgrip1.L
uniprot id: A0A8J0V4Z0
names: Similarity
messages: Belongs to the RPGRIP1 family.

8355:tubb4b.S
gene id: 8355:tubb4b.S
uniprot id: A0A8J1LK88
uniprot id: Q7ZY50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:rnft1.L
gene id: 8355:rnft1.L
uniprot id: Q6NTV1
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.
messages: Endoplasmic reticulum membrane

8355:LOC108709579
gene id: 8355:LOC108709579
uniprot id: A0A1L8H7S4
uniprot id: A0A8J0UKP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

8355:LOC108713997
gene id: 8355:LOC108713997
uniprot id: A0A1L8GKJ4
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108713762
gene id: 8355:LOC108713762
uniprot id: A0A1L8GIM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:sem1.S
gene id: 8355:sem1.S
uniprot id: Q66KW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

8355:id2.S
gene id: 8355:id2.S
uniprot id: Q66J78
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer with other HLH proteins.
messages: Nucleus
messages: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Inhibits the activity of both neurogenic (neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors. May play a role in the regulation of the circadian clock (By similarity).

8355:LOC108703409
gene id: 8355:LOC108703409
uniprot id: A0A8J1MU39
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:LOC121399059
gene id: 8355:LOC121399059
uniprot id: A0A8J1LZA3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:nusap1.S
gene id: 8355:nusap1.S
uniprot id: Q1W1G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NUSAP family.
messages: Cytoplasm
messages: Interacts with DNA (By similarity). Interacts with microtubules, ipo7, kpna2 and kpnb1. Microtubule stabilization is inhibited by ipo7 and kpna2, while microtubule bundling is inhibited by kpnb1. Active GTP-bound ran causes dissociation of ipo7 and kpnb1.
messages: Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of meiotic or mitotic spindle microtubules around them.
messages: Nucleus
messages: spindle

8355:MGC81124
gene id: 8355:MGC81124
uniprot id: Q6NU96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

8355:mal2.S
gene id: 8355:mal2.S
uniprot id: Q6GNS0
names: Subcellular Location Annotation
messages: Membrane

8355:rnf31.S
gene id: 8355:rnf31.S
uniprot id: A0A1L8HPJ6
uniprot id: A0A8J0U2P5
uniprot id: A0A8J0U2Q5
uniprot id: A0A8J0U5Z4
uniprot id: A0JMU3
names: Similarity
messages: Belongs to the RBR family.

8355:LOC108704779
gene id: 8355:LOC108704779
uniprot id: A0A8J0TXK6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108701938
gene id: 8355:LOC108701938
uniprot id: A0A1L8EZ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cnmd.L
gene id: 8355:cnmd.L
uniprot id: Q7ZY92
names: Similarity
messages: Belongs to the chondromodulin-1 family.

8355:uts2.S
gene id: 8355:uts2.S
uniprot id: J7M452
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

8355:irx1.S
gene id: 8355:irx1.S
uniprot id: Q2TAQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds to the bmp4 promoter to repress gene expression and thus mediate down-regulation of bmp4 by wnt signaling. Controls multiple processes through bmp4-repression including neural plate development, neural crest specification and Spemann organizer development. Involved in the specification of the preplacodal field at the anterior border of the neural plate. Regulates the genetic cascade of interactions that are necessary for positioning the isthmus organizer and the formation of the midbrain-hindbrain boundary. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros. Acts principally as a transcriptional activator during pronephros development (By similarity).
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

8355:atp6v1h.S
gene id: 8355:atp6v1h.S
uniprot id: A0A1L8FT39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8355:bpnt2.S
gene id: 8355:bpnt2.S
uniprot id: Q6NTW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily.
messages: Membrane

8355:stx5.L
gene id: 8355:stx5.L
uniprot id: A0A8J1MU66
uniprot id: Q3KPJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

8355:LOC108715094
gene id: 8355:LOC108715094
uniprot id: A0A1L8GFC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:htr1b.S
gene id: 8355:htr1b.S
uniprot id: A0A8J0VJG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1D.
messages: Membrane

8355:LOC108710419
gene id: 8355:LOC108710419
uniprot id: A0A8J0UGK6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:pmp22.S
gene id: 8355:pmp22.S
uniprot id: Q6DCV9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

8355:lmf2.S
gene id: 8355:lmf2.S
uniprot id: A0A8J1MRA6
uniprot id: A0A8J1MSK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

8355:jag2.S
gene id: 8355:jag2.S
uniprot id: A0A1L8EZY8
uniprot id: A0A8J0TQ46
uniprot id: A0A8J1LNB0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8355:LOC108706367
gene id: 8355:LOC108706367
uniprot id: A0A8J0U7E7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:ddah1.S
gene id: 8355:ddah1.S
uniprot id: A0A1L8GF45
uniprot id: A0A8J1KIR4
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

8355:txndc5.S
gene id: 8355:txndc5.S
uniprot id: A0A1L8FS49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

8355:LOC108707447
gene id: 8355:LOC108707447
uniprot id: A0A8J1M9F4
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8355:pcdhga3.L
gene id: 8355:pcdhga3.L
uniprot id: A0A8J0UEX2
uniprot id: A0A8J0UEX8
uniprot id: A0A8J0ULL8
uniprot id: A0A8J0ULM3
uniprot id: A0A8J0UMW9
uniprot id: A0A8J0UMX4
uniprot id: A0A8J0UMY3
uniprot id: A0A8J0UQY0
uniprot id: A0A8J0UQY4
uniprot id: A0A8J1MGI5
uniprot id: A0A8J1MGI7
uniprot id: A0A8J1MGI9
uniprot id: A0A8J1MGJ0
uniprot id: A0A8J1MGJ4
uniprot id: A0A8J1MGJ6
uniprot id: A0A8J1MGJ9
uniprot id: A0A8J1MGK1
uniprot id: A0A8J1MGK3
uniprot id: A0A8J1MGK7
uniprot id: A0A8J1MGK9
uniprot id: A0A8J1MGL2
uniprot id: A0A8J1MGL3
uniprot id: A0A8J1MH26
uniprot id: A0A8J1MH31
uniprot id: A0A8J1MH36
uniprot id: A0A8J1MH39
uniprot id: A0A8J1MH44
uniprot id: A0A8J1MH49
uniprot id: A0A8J1MH54
uniprot id: A0A8J1MHG9
uniprot id: A0A8J1MHH5
uniprot id: A0A8J1MHH9
uniprot id: A0A8J1MHI3
uniprot id: A0A8J1MHI7
uniprot id: A0A8J1MHJ1
uniprot id: A0A8J1MHJ6
uniprot id: A0A8J1MIE1
uniprot id: A0A8J1MIE6
uniprot id: A0A8J1MIF1
uniprot id: A0A8J1MIF5
uniprot id: A0A8J1MIF9
uniprot id: A0A8J1MIG5
uniprot id: A0A8J1MIG9
uniprot id: Q7ZX86
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8355:ncstn.L
gene id: 8355:ncstn.L
uniprot id: A0A1L8FCM9
uniprot id: A0A8J0TLP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

8355:LOC108699995
gene id: 8355:LOC108699995
uniprot id: A0A1L8F1U1
uniprot id: A0A8J0TMZ5
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

8355:ern2.S
gene id: 8355:ern2.S
uniprot id: Q6GPM2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:f5.L
gene id: 8355:f5.L
uniprot id: A0A1L8HF82
names: Similarity
messages: Belongs to the multicopper oxidase family.

8355:cyp2a6.2.S
gene id: 8355:cyp2a6.2.S
uniprot id: A0A1L8F3W7
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108696439
gene id: 8355:LOC108696439
uniprot id: A0A8J0TB09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:vps37a.L
gene id: 8355:vps37a.L
uniprot id: A0A1L8HU43
uniprot id: Q0IHC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

8355:LOC108710546
gene id: 8355:LOC108710546
uniprot id: A0A1L8H4K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:bud31.S
gene id: 8355:bud31.S
uniprot id: A0A1L8EXA3
uniprot id: P12805
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BUD31 (G10) family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing process.
messages: Nucleus
messages: Oocyte maturation is accompanied by the recruitment of specific maternal mRNAs into polysomes. G10 is an example of a protein which is translated at that time.

8355:LOC108697033
gene id: 8355:LOC108697033
uniprot id: A0A8J0TD48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:ccne1.S
gene id: 8355:ccne1.S
uniprot id: O42575
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin E subfamily.
messages: Essential for the control of the cell cycle at the G1/S (start) transition.
messages: Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
messages: Nucleus
messages: Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.

8355:LOC108695857
gene id: 8355:LOC108695857
uniprot id: A0A1L8FME4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:eml3.L
gene id: 8355:eml3.L
uniprot id: A0A1L8GJX2
names: Similarity
messages: Belongs to the WD repeat EMAP family.

8355:kif20a.L
gene id: 8355:kif20a.L
uniprot id: A0A1L8GY32
uniprot id: Q6DEA8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:alg13l.L
gene id: 8355:alg13l.L
uniprot id: Q6NRA3
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

8355:LOC108719466
gene id: 8355:LOC108719466
uniprot id: A0A1L8G0E9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:ube3d.S
gene id: 8355:ube3d.S
uniprot id: Q5PQ45
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

8355:pla1a.L
gene id: 8355:pla1a.L
uniprot id: A0A1L8HC38
uniprot id: A0A8J1M6L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8355:pgap6.L
gene id: 8355:pgap6.L
uniprot id: A0A1L8EYS5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:mospd1.L
gene id: 8355:mospd1.L
uniprot id: A0A8J1LFQ9
uniprot id: Q7SYQ6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

8355:onecut2.L
gene id: 8355:onecut2.L
uniprot id: A0A1L8I2Q1
uniprot id: A0A8J0VJ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8355:hnf4a.S
gene id: 8355:hnf4a.S
uniprot id: A0A8J1LW19
uniprot id: Q91766
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Binds fatty acids.
messages: Expressed in liver and kidney.
messages: Homodimerization is required for HNF4-alpha to bind to its recognition site.
messages: Maternal protein which is distributed within an animal-to-vegetal gradient in the embryo. Present throughout the entire development.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional regulator; binds and activates the promoter for the HNF1-alpha gene (PubMed:8808405). Potential initiator of a transcriptional cascade within a subset of cells committed to a specific developmental program (PubMed:8808405). Could be a determinant for asymmetry in early development (PubMed:8808405). May play a role in the regulation of the circadian clock (By similarity).

8355:tmem233.S
gene id: 8355:tmem233.S
uniprot id: A0A8J1M3C9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:med16.L
gene id: 8355:med16.L
uniprot id: A0A1L8HWL9
uniprot id: Q566H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:vta1.L
gene id: 8355:vta1.L
uniprot id: Q66IX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

8355:arhgap33.L
gene id: 8355:arhgap33.L
uniprot id: A0A8J1L8A2
uniprot id: A0A8J1L9V5
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

8355:atxn1.L
gene id: 8355:atxn1.L
uniprot id: A0A8J1KY62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

8355:arhgap45.L
gene id: 8355:arhgap45.L
uniprot id: Q6DE55
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity.
messages: Cytoplasm
messages: Rho-GAP domain is able to regulate RhoGTPase activity, actin cytoskeleton and cell spreading. However N-terminally BAR domain plays an autoinhibitory role.
messages: ruffle membrane

8355:hmga2.S
gene id: 8355:hmga2.S
uniprot id: A0A8J0USU7
uniprot id: A0A8J0UXC2
uniprot id: Q08AX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

8355:grin3a.S
gene id: 8355:grin3a.S
uniprot id: A0A8J1M2S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:mpp4.L
gene id: 8355:mpp4.L
uniprot id: A0A8J1LS22
uniprot id: A0A8J1LS57
uniprot id: A0A8J1LST7
uniprot id: A0A8J1LTH0
uniprot id: A0A8J1LTH6
uniprot id: A0A8J1LUG2
names: Similarity
messages: Belongs to the MAGUK family.

8355:ntrk1.S
gene id: 8355:ntrk1.S
uniprot id: A0A1L8F4K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:LOC108707190
gene id: 8355:LOC108707190
uniprot id: A0A8J0UAF0
uniprot id: A0A8J0UD36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

8355:fam83f.S
gene id: 8355:fam83f.S
uniprot id: A0A1L8GGY8
names: Similarity
messages: Belongs to the FAM83 family.

8355:svep1.L
gene id: 8355:svep1.L
uniprot id: A0A1L8HXT3
uniprot id: A0A8J0UZT6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:p2ry8.L
gene id: 8355:p2ry8.L
uniprot id: A0A1L8HDD7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:KEF37 p06
gene id: 8355:KEF37_p06
uniprot id: P03900
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion membrane

8355:LOC121399028
gene id: 8355:LOC121399028
uniprot id: A0A8J1LZ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actinoporin family. Sea anemone subfamily.
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

8355:tmprss9.L
gene id: 8355:tmprss9.L
uniprot id: A0A1L8HVY8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:nkain4.S
gene id: 8355:nkain4.S
uniprot id: A0A8J0TY17
uniprot id: Q32NX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Interacts with atp1b1 C-terminus.
messages: Membrane

8355:tff3.5.L
gene id: 8355:tff3.5.L
uniprot id: A0A8J1M5X3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:six4.L
gene id: 8355:six4.L
uniprot id: A0A8J0TCG0
uniprot id: A0A8J0TK91
names: Subcellular Location Annotation
messages: Nucleus

8355:blm.S
gene id: 8355:blm.S
uniprot id: A0A1L8GSC3
uniprot id: A0A8J0UU04
uniprot id: A0A8J1MPR8
uniprot id: Q9DEY9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair (PubMed:11040210). Involved in 5'-end resection of DNA during double-strand break (DSB) repair. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction.
messages: Belongs to the helicase family. RecQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer. Homodimer (via N-terminus). Homotetramer (via N-terminus); dimer of dimers. Homohexamer (via N-terminus). Self-association negatively regulates DNA unwinding amplitude and rate. Oligomer complexes dissociate into monomer in presence of ATP.
messages: Nucleus
messages: The N-terminal region mediates dimerization and homooligomerization. Both the helicase ATP-binding domain and the helicase C-terminal domain form intramolecular interactions with the HRDC domain in a ATP-dependent manner. The HRDC domain is required for single-stranded DNA (ssDNA) and DNA Holliday junction binding.

8355:KEF37 p07
gene id: 8355:KEF37_p07
uniprot id: P00419
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

8355:LOC108703876
gene id: 8355:LOC108703876
uniprot id: A0A8J1LSW1
uniprot id: A0A8J1LTI6
uniprot id: A0A8J1LUB3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:LOC496367
gene id: 8355:LOC496367
uniprot id: Q5HZL2
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

8355:LOC108715150
gene id: 8355:LOC108715150
uniprot id: A0A1L8GDB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

8355:LOC108710778
gene id: 8355:LOC108710778
uniprot id: A0A8J1MKP9
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:ablim3.S
gene id: 8355:ablim3.S
uniprot id: A0A8J0UX20
uniprot id: A0A8J0UY15
uniprot id: A0A8J0UY95
uniprot id: A0A8J0V1V2
uniprot id: A0A8J1MS45
uniprot id: A0A8J1MSA1
uniprot id: A0A8J1MSA5
uniprot id: A0A8J1MT59
uniprot id: A0A8J1MT63
uniprot id: A0A8J1MTH2
names: Subcellular Location Annotation
messages: Cytoplasm

8355:atp6v1g3.L
gene id: 8355:atp6v1g3.L
uniprot id: Q5XGW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

8355:fat4.S
gene id: 8355:fat4.S
uniprot id: A0A1L8HLV5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108714414
gene id: 8355:LOC108714414
uniprot id: A0A8J0V2Z5
uniprot id: A0A8J1MXH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8355:slc35e3.S
gene id: 8355:slc35e3.S
uniprot id: A0A1L8GUF1
uniprot id: A0A8J0V1F8
names: Subcellular Location Annotation
messages: Membrane

8355:nhej1.S
gene id: 8355:nhej1.S
uniprot id: A0A1L8ENT6
uniprot id: A0A8J0U087
uniprot id: A0A8J0U1H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

8355:dctd.L
gene id: 8355:dctd.L
uniprot id: A0A8J0UC55
uniprot id: Q6NU69
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

8355:tub.S
gene id: 8355:tub.S
uniprot id: A0A1L8GE89
uniprot id: A0A8J0V501
uniprot id: A0A8J1MZN6
uniprot id: A0A8J1N236
uniprot id: Q6DE52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

8355:LOC108697167
gene id: 8355:LOC108697167
uniprot id: A0A1L8FE08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:plxnb1.S
gene id: 8355:plxnb1.S
uniprot id: A0A1L8GHW9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:tmem14a.L
gene id: 8355:tmem14a.L
uniprot id: A0A8J0VGV8
names: Similarity
messages: Belongs to the TMEM14 family.

8355:garem1.S
gene id: 8355:garem1.S
uniprot id: Q6NRE4
names: Function
names: Similarity
messages: Adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway. May promote cell proliferation (By similarity).
messages: Belongs to the GAREM family.

8355:micall1.S
gene id: 8355:micall1.S
uniprot id: A0A1L8GH45
names: Subcellular Location Annotation
messages: Membrane

8355:eif2a.L
gene id: 8355:eif2a.L
uniprot id: A0A1L8GAF3
uniprot id: A0A8J0VD98
uniprot id: A0A8J1KRC9
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

8355:hpgd.L
gene id: 8355:hpgd.L
uniprot id: Q6DCY5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:tubb6.S
gene id: 8355:tubb6.S
uniprot id: Q8AVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:grm8.S
gene id: 8355:grm8.S
uniprot id: A0A8J1MRL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8355:LOC108699171
gene id: 8355:LOC108699171
uniprot id: A0A8J1LIM5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

8355:rdh8.L
gene id: 8355:rdh8.L
uniprot id: A0A8J0UPA1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:LOC108703007
gene id: 8355:LOC108703007
uniprot id: A0A1L8EPB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:pcmt1.L
gene id: 8355:pcmt1.L
uniprot id: A0A8J0V9X5
uniprot id: A0A8J1KLJ9
uniprot id: Q5U253
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

8355:lzts2.L
gene id: 8355:lzts2.L
uniprot id: A0A1L8FJA7
uniprot id: A0A8J1L524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

8355:LOC121396950
gene id: 8355:LOC121396950
uniprot id: A0A8J1LG90
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:pard6b.S
gene id: 8355:pard6b.S
uniprot id: A0A1L8ELH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

8355:ssu72.L
gene id: 8355:ssu72.L
uniprot id: Q6NRQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSU72 phosphatase family.
messages: Cytoplasm
messages: May be involved in the C-terminal domain of RNA polymerase II dephosphorylation, RNA processing and termination.
messages: Nucleus

8355:mdm4.S
gene id: 8355:mdm4.S
uniprot id: A0A8J0U9Z9
uniprot id: A0A8J0UI71
uniprot id: Q7ZYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM2/MDM4 family.
messages: Binds to p53 and p73.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

8355:tmed2.L
gene id: 8355:tmed2.L
uniprot id: Q7ZXW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

8355:yaf2.S
gene id: 8355:yaf2.S
uniprot id: A0A8J0UXE2
uniprot id: Q3KQD2
names: Subcellular Location Annotation
messages: Nucleus

8355:fam110b.S
gene id: 8355:fam110b.S
uniprot id: A0A1L8FT63
names: Similarity
messages: Belongs to the FAM110 family.

8355:ccdc149.L
gene id: 8355:ccdc149.L
uniprot id: A0A8J0TEW3
uniprot id: A0A8J0THK1
uniprot id: A0A8J0THK5
uniprot id: A0A8J0TID0
names: Similarity
messages: Belongs to the CCDC149 family.

8355:LOC108697991
gene id: 8355:LOC108697991
uniprot id: A0A8J0TDS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

8355:adra1d.L
gene id: 8355:adra1d.L
uniprot id: A0A1L8HSD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

8355:LOC108700309
gene id: 8355:LOC108700309
uniprot id: A0A1L8F457
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8355:LOC108703449
gene id: 8355:LOC108703449
uniprot id: A0A8J0U241
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108700581
gene id: 8355:LOC108700581
uniprot id: A0A8J1LNW8
uniprot id: A0A8J1LPW6
uniprot id: A0A8J1LQ72
uniprot id: A0A8J1LRC2
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8355:acvr2a.S
gene id: 8355:acvr2a.S
uniprot id: A0A8J1LW64
uniprot id: A0A8J1LW81
uniprot id: Q9PSM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8355:flot1.L
gene id: 8355:flot1.L
uniprot id: Q8AWZ5
uniprot id: Q8AWZ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane

8355:mtmr2.L
gene id: 8355:mtmr2.L
uniprot id: A0A1L8HJA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

8355:slitrk3.L
gene id: 8355:slitrk3.L
uniprot id: A0A8J0VCD3
names: Similarity
messages: Belongs to the SLITRK family.

8355:LOC108701936
gene id: 8355:LOC108701936
uniprot id: A0A1L8EZ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108711333
gene id: 8355:LOC108711333
uniprot id: A0A8J0URZ3
uniprot id: A0A8J0UVB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:thrap3.S
gene id: 8355:thrap3.S
uniprot id: A0A8J1MB97
uniprot id: A0A8J1MB98
uniprot id: A0A8J1MBL1
uniprot id: A0A8J1MC90
uniprot id: Q2TAF1
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

8355:gstt1-like.2.L
gene id: 8355:gstt1-like.2.L
uniprot id: A0A1L8I0H1
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

8355:LOC121396357
gene id: 8355:LOC121396357
uniprot id: A0A1L8FE02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:glul-like.1.S
gene id: 8355:glul-like.1.S
uniprot id: Q7SZ38
names: Similarity
messages: Belongs to the glutamine synthetase family.

8355:fkrp.L
gene id: 8355:fkrp.L
uniprot id: A0A1L8F835
names: Similarity
messages: Belongs to the LicD transferase family.

8355:crebl2.L
gene id: 8355:crebl2.L
uniprot id: A0A8J0U557
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

8355:tcf7l1.L
gene id: 8355:tcf7l1.L
uniprot id: B7ZQ53
uniprot id: P70062
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCF/LEF family.
messages: Cytoplasm
messages: Interacts with csnk1e, ctnnb1-A, ctbp-B, dact1-A and gsk3b. May interact with ase and tle4-A.
messages: Nucleus
messages: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of ctnnb1-A and possibly ctnnb1-B, and as an activator in the presence of these proteins. Required early in development for the establishment of the dorsal body axis in response to maternal Wnt signaling. Also required during development of the CNS for the establishment of dorsal-ventral patterning in the prospective diencephalon.
messages: Phosphorylated. Phosphorylation by csnk1e promotes binding to ctnnb1-A while phosphorylation by gsk3b may reverse this effect.

8355:insm1.S
gene id: 8355:insm1.S
uniprot id: A0A1L8G1M5
names: Subcellular Location Annotation
messages: Nucleus

8355:slc41a2.L
gene id: 8355:slc41a2.L
uniprot id: Q6DFC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a plasma-membrane magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane

8355:tptep2-csnk1e.L
gene id: 8355:tptep2-csnk1e.L
uniprot id: Q9PUI2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:fut3.L
gene id: 8355:fut3.L
uniprot id: A0A1L8GJN4
uniprot id: Q6WNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8355:sox12.S
gene id: 8355:sox12.S
uniprot id: A0A1L8EKH1
uniprot id: Q8AXQ4
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed at a low level in embryos, and in the adult lung, ovary, skeletal muscle, testis, brain and heart.
messages: Nucleus
messages: Transcription factor that binds to the sequence 5'-AACAAT-3' (PubMed:12890561). Acts as a transcriptional activator (By similarity).
messages: Zygotic expression begins after mid-blastula and expression levels rise gradually up to stage 41.

8355:entpd1.S
gene id: 8355:entpd1.S
uniprot id: A0A1L8FEY6
uniprot id: A0A8J1LBQ6
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

8355:LOC108718459
gene id: 8355:LOC108718459
uniprot id: A0A8J1KWI8
uniprot id: A0A8J1KWJ2
uniprot id: A0A8J1KWJ6
uniprot id: A0A8J1KY60
names: Similarity
messages: Belongs to the CCM2 family.

8355:grhl1.L
gene id: 8355:grhl1.L
uniprot id: Q5EY87
names: Developmental Stage
names: Disease Annotation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After fertilization, expressed at the animal pole. Expression becomes restricted to the non-neuronal ectoderm of the embryo with progression through gastrulation and neurulation. Expression is observed only in the most superficial cellular layer of the embryo, being absent from the neural plate At later stages, expression is restricted to tissues with an epidermal fate.
messages: Belongs to the grh/CP2 family. Grainyhead subfamily.
messages: Binds DNA as homodimer.
messages: Defects in grhl1 are the cause of defective epidermal differentiation.
messages: GRHL genes (GRHL1, GRHL2 and GRHL3) show a paradoxal lack of redundancy despite their extensive sequence identity in the DNA-binding and protein dimerization domains and the fact that the core consensus DNA binding sites are identical. They have related but remarkably different functions during embryogenesis because of their differential spatiotemporal expression patterns during development.
messages: Nucleus
messages: Transcription factor involved in epithelial development (PubMed:15705857). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' and modulates expression of epidermal-specific genes, including XK81A1 (PubMed:15705857). Important regulator of DSG1 in the context of epidermal differentiation. Regulates the maintenance of skin barrier. No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Functions downstream of BMP-signaling cascade modulating endogenous bmp4-responsive targets (PubMed:15705857).

8355:cnr1.L
gene id: 8355:cnr1.L
uniprot id: A0A1L8G9R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Signaling typically involves reduction in cyclic AMP.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

8355:LOC108716695
gene id: 8355:LOC108716695
uniprot id: A0A1L8G7X4
uniprot id: A0A8J0VG11
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:fundc1.L
gene id: 8355:fundc1.L
uniprot id: Q6DFJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

8355:LOC108706787
gene id: 8355:LOC108706787
uniprot id: A0A1L8HMQ0
names: Subcellular Location Annotation
messages: Membrane

8355:zdhhc2.L
gene id: 8355:zdhhc2.L
uniprot id: A0A8J0UBE4
uniprot id: Q6INC7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:kiaa1522.S
gene id: 8355:kiaa1522.S
uniprot id: A0A310U7A3
uniprot id: A0A8J0TY45
names: Similarity
messages: Belongs to the NHS family.

8355:LOC108705325
gene id: 8355:LOC108705325
uniprot id: A0A8J0U9G1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:kdsr.L
gene id: 8355:kdsr.L
uniprot id: A0A8J0VMQ0
uniprot id: Q6NUD3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:wdr44.L
gene id: 8355:wdr44.L
uniprot id: Q498F0
names: Function
names: Subcellular Location Annotation
messages: Downstream effector for rab11. May be involved in vesicle recycling (By similarity).
messages: Endosome membrane
messages: cytosol
messages: perinuclear region
messages: trans-Golgi network

8355:LOC108707848
gene id: 8355:LOC108707848
uniprot id: A0A8J0UDE3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rab3a.L
gene id: 8355:rab3a.L
uniprot id: Q5U507
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

8355:tns2.S
gene id: 8355:tns2.S
uniprot id: A0A1L8HA90
uniprot id: A0A8J0ULW8
uniprot id: A0A8J0UPU8
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

8355:LOC108712290
gene id: 8355:LOC108712290
uniprot id: A0A8J0UTW2
names: Similarity
messages: Belongs to the CKAP2 family.

8355:slc7a2.1.S
gene id: 8355:slc7a2.1.S
uniprot id: A0A1L8HLD4
uniprot id: A0A8J0UAR1
uniprot id: A0A8J1M166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

8355:cpb2.L
gene id: 8355:cpb2.L
uniprot id: A0A8J0UG98
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:LOC108703229
gene id: 8355:LOC108703229
uniprot id: A0A8J0U1B8
uniprot id: A0A8J0U2L1
names: Similarity
messages: Belongs to the mesothelin family.

8355:pias3.L
gene id: 8355:pias3.L
uniprot id: A0A8J0TES5
uniprot id: Q6GMA8
names: Similarity
messages: Belongs to the PIAS family.

8355:hrh4.b2.L
gene id: 8355:hrh4.b2.L
uniprot id: A0A1L8FYR1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108708726
gene id: 8355:LOC108708726
uniprot id: A0A8J1MA74
uniprot id: A0A8J1MA81
uniprot id: A0A8J1MAI3
uniprot id: A0A8J1MBZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

8355:mrps21.S
gene id: 8355:mrps21.S
uniprot id: A0A1L8F4J0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

8355:slc15a4.S
gene id: 8355:slc15a4.S
uniprot id: A0A1L8HQJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

8355:LOC108700968
gene id: 8355:LOC108700968
uniprot id: A0A1L8ETC1
names: Similarity
messages: Belongs to the tubulin--tyrosine ligase family.

8355:fcho1.S
gene id: 8355:fcho1.S
uniprot id: A0A8J0U2E2
uniprot id: A0A8J1M2N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

8355:enosf1.S
gene id: 8355:enosf1.S
uniprot id: Q6INX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Mitochondrion
messages: Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. May down-regulate thymidylate synthase activity, possibly already at the RNA level, by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism.

8355:LOC108699343
gene id: 8355:LOC108699343
uniprot id: A0A8J0TLF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:ptk2b.L
gene id: 8355:ptk2b.L
uniprot id: A0A1L8GC06
uniprot id: A0A8J0VD51
uniprot id: A0A8J1KQE7
names: Subcellular Location Annotation
messages: Cell membrane
messages: focal adhesion

8355:LOC108698820
gene id: 8355:LOC108698820
uniprot id: A0A8J0TIN1
uniprot id: A0A8J1MT88
uniprot id: A0A8J1MTF4
uniprot id: A0A8J1MUM5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:cnot1.L
gene id: 8355:cnot1.L
uniprot id: A0A1L8GLF8
uniprot id: A0A8J0V1J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

8355:pa2g4.S
gene id: 8355:pa2g4.S
uniprot id: Q5U5C4
names: Similarity
messages: Belongs to the peptidase M24 family.

8355:LOC108701930
gene id: 8355:LOC108701930
uniprot id: A0A8J0TZN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:ss18l1.L
gene id: 8355:ss18l1.L
uniprot id: A0A1L8ESY2
names: Similarity
messages: Belongs to the SS18 family.

8355:fam110c.S
gene id: 8355:fam110c.S
uniprot id: A0A1L8G5D1
names: Similarity
messages: Belongs to the FAM110 family.

8355:lin7a.S
gene id: 8355:lin7a.S
uniprot id: A0A1L8GUQ9
uniprot id: A0A8J1MS39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.

8355:tsc22d2.L
gene id: 8355:tsc22d2.L
uniprot id: A0A1L8GAL4
uniprot id: A0A8J0V926
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

8355:LOC108697535
gene id: 8355:LOC108697535
uniprot id: A0A8J1LC75
uniprot id: A0A8J1LC78
uniprot id: A0A8J1LC93
uniprot id: A0A8J1LCA3
uniprot id: A0A8J1LCE5
uniprot id: A0A8J1LCF0
uniprot id: A0A8J1LDS9
uniprot id: A0A8J1LEQ7
names: Similarity
messages: Belongs to the syntaxin family.

8355:mpv17l.S
gene id: 8355:mpv17l.S
uniprot id: Q68F62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Participates in reactive oxygen species metabolism.
messages: Peroxisome membrane

8355:zdhhc9.L
gene id: 8355:zdhhc9.L
uniprot id: A0A8J0TJG7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:trhr2.L
gene id: 8355:trhr2.L
uniprot id: B7ZQE5
uniprot id: Q9DDR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

8355:LOC108712399
gene id: 8355:LOC108712399
uniprot id: A0A1L8GV44
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:ift122.L
gene id: 8355:ift122.L
uniprot id: A0A1L8GPM1
names: Subcellular Location Annotation
messages: cilium

8355:cpa1.S
gene id: 8355:cpa1.S
uniprot id: A0A8J0UXG9
uniprot id: Q6PGR7
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:vax2.L
gene id: 8355:vax2.L
uniprot id: B7ZR64
uniprot id: Q9PU20
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Expression begins at early neurula stage in the anterior neural plate whereas, at late neurula stage detected in the area which gives rise to ventral telencephalic and diencephalic regions and the eye. After neural tube closure and evagination of the optic vesicles at the early tail-bud stage, expression is specifically restricted to anterior and ventral neural structures, namely the ventral part of the optic vesicles and the ventral regions of the forebrain vesicle. This expression pattern is maintained during subsequent developmental stages. In tadpole embryos, specifically expressed in the ventral regions of both telencephalon and diencephalon.
messages: Nucleus
messages: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated tcf7l2 isoform that cannot bind ctnnb1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina.

8355:cltc.S
gene id: 8355:cltc.S
uniprot id: A0A1L8H7Y9
uniprot id: A0A8J1ME78
uniprot id: A0A8J1MEP3
uniprot id: A0A8J1MF51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

8355:fam133b.S
gene id: 8355:fam133b.S
uniprot id: A0A1L8FR23
uniprot id: A0A8J0VMR2
names: Similarity
messages: Belongs to the FAM133 family.

8355:LOC108708774
gene id: 8355:LOC108708774
uniprot id: A0A8J0U994
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108717059
gene id: 8355:LOC108717059
uniprot id: A0A8J0VHK3
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

8355:ddr2.L
gene id: 8355:ddr2.L
uniprot id: A0A1L8GNQ5
uniprot id: A0A8J1MYS6
names: Subcellular Location Annotation
messages: Membrane

8355:mmp11.S
gene id: 8355:mmp11.S
uniprot id: A0A1L8HQD4
names: Similarity
messages: Belongs to the peptidase M10A family.

8355:rpl30.S
gene id: 8355:rpl30.S
uniprot id: Q7SZC0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

8355:rps15.S
gene id: 8355:rps15.S
uniprot id: A0A1L8HNA1
uniprot id: A0A8J1LIC4
uniprot id: P20342
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

8355:mief1.S
gene id: 8355:mief1.S
uniprot id: Q569T9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

8355:cacna2d1.L
gene id: 8355:cacna2d1.L
uniprot id: A0A8J0UUP3
uniprot id: A0A8J1ML44
uniprot id: A0A8J1ML72
uniprot id: A0A8J1MLZ8
uniprot id: A0A8J1MM38
uniprot id: A0A8J1MN54
uniprot id: A0A8J1MN59
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

8355:LOC108708497
gene id: 8355:LOC108708497
uniprot id: A0A1L8HHK5
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108702853
gene id: 8355:LOC108702853
uniprot id: A0A1L8EN83
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121395369
gene id: 8355:LOC121395369
uniprot id: A0A8J1L547
uniprot id: A0A8J1L548
names: Subcellular Location Annotation
messages: Membrane

8355:cox7b.S
gene id: 8355:cox7b.S
uniprot id: A0A1L8F2E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

8355:l3mbtl2.L
gene id: 8355:l3mbtl2.L
uniprot id: A0A1L8GNG9
uniprot id: A0A8J1MXJ0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.
messages: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.

8355:dhx15.S
gene id: 8355:dhx15.S
uniprot id: A0A1L8HKX4
uniprot id: A0A8J0U7U0
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

8355:mymk.S
gene id: 8355:mymk.S
uniprot id: A0A1L8F0Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

8355:LOC108698369
gene id: 8355:LOC108698369
uniprot id: A0A1L8F773
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8355:zbtb8a.1.S
gene id: 8355:zbtb8a.1.S
uniprot id: A1L2U9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

8355:etfa.L
gene id: 8355:etfa.L
uniprot id: Q3KQG0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

8355:LOC108716610
gene id: 8355:LOC108716610
uniprot id: A0A1L8G787
names: Subcellular Location Annotation
messages: extracellular space

8355:spats2.L
gene id: 8355:spats2.L
uniprot id: A0A8J0UC72
uniprot id: Q6DD76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

8355:inpp5a.1.L
gene id: 8355:inpp5a.1.L
uniprot id: A0A1L8FJ28
uniprot id: A0A8J0TAG7
uniprot id: A0A8J1L9I7
uniprot id: A0A8J1LC11
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

8355:slc25a45.S
gene id: 8355:slc25a45.S
uniprot id: A0A1L8GCY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:atp1b2.L
gene id: 8355:atp1b2.L
uniprot id: Q9DEN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8355:sh3gl2.S
gene id: 8355:sh3gl2.S
uniprot id: Q4V7Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

8355:LOC108705522
gene id: 8355:LOC108705522
uniprot id: A0A8J1M4F9
uniprot id: A0A8J1M4G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

8355:abhd16a.S
gene id: 8355:abhd16a.S
uniprot id: A0A8J0PQV5
uniprot id: Q860X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

8355:osbp2.S
gene id: 8355:osbp2.S
uniprot id: A0A8J0UD31
names: Similarity
messages: Belongs to the OSBP family.

8355:ralb.S
gene id: 8355:ralb.S
uniprot id: Q6IP71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Interacts with ralbp1 and rap1gds1.
messages: Midbody
messages: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Regulates the actin cytoskeleton to play a role in gastrulation or neurulation. During the cleavage stages, the GTP-bound form induces a cortical reaction that affects the localization of pigment granules. Activated by the FGF pathway via ras and ral-GDS, but independently of raf. Directs ralbp1 to the plasma membrane (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity).

8355:vwc2l.2.S
gene id: 8355:vwc2l.2.S
uniprot id: A0A1L8GFR2
names: Subcellular Location Annotation
messages: Synapse

8355:LOC108699412
gene id: 8355:LOC108699412
uniprot id: A0A8J0TDX1
uniprot id: A0A8J0TMH6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8355:lbx1.L
gene id: 8355:lbx1.L
uniprot id: Q2PYN8
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in all myoblasts that will populate body wall muscles as well as in a group of cells the migrate into the head.
messages: Nucleus
messages: Transcription factor that controls hypaxial muscle development by down-regulating myod1 and cdkn1b/p27, thereby allowing myoblasts to proliferate before the onset of terminal differentiation.

8355:kdm5b.S
gene id: 8355:kdm5b.S
uniprot id: A0A8J0UCB4
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

8355:senp3.L
gene id: 8355:senp3.L
uniprot id: Q5XG28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

8355:tekt4.S
gene id: 8355:tekt4.S
uniprot id: Q5PPV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Contributes to normal sperm motility (By similarity).
messages: cilium axoneme
messages: flagellum

8355:strip2.L
gene id: 8355:strip2.L
uniprot id: A0A8J0UJC7
names: Similarity
messages: Belongs to the STRIP family.

8355:efhc1.L
gene id: 8355:efhc1.L
uniprot id: A0A8J0VDW9
uniprot id: Q6DJD5
names: Subcellular Location Annotation
messages: cilium axoneme

8355:slc49a4.L
gene id: 8355:slc49a4.L
uniprot id: Q6GNV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Electrogenic metabolite transporter.
messages: Lysosome membrane

8355:pif1.L
gene id: 8355:pif1.L
uniprot id: Q0R4F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
messages: Mitochondrion
messages: Monomer.
messages: Nucleus

8355:cyp3a5.L
gene id: 8355:cyp3a5.L
uniprot id: A0A1L8FWD2
uniprot id: A0A8J1KXL5
uniprot id: Q5U557
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:hbegf.S
gene id: 8355:hbegf.S
uniprot id: A0A1L8GVF5
uniprot id: A0A8J0UYD9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ppm1l.L
gene id: 8355:ppm1l.L
uniprot id: A0A1L8GAP4
uniprot id: A0A1L8GAS5
names: Similarity
messages: Belongs to the PP2C family.

8355:polr2f.L
gene id: 8355:polr2f.L
uniprot id: A0A1L8GNW1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

8355:fam13b.L
gene id: 8355:fam13b.L
uniprot id: A0A1L8GXE5
names: Similarity
messages: Belongs to the FAM13 family.

8355:ggps1.L
gene id: 8355:ggps1.L
uniprot id: A0A8J0V8B8
uniprot id: A0A8J0VD22
uniprot id: A3KNC6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

8355:LOC108714471
gene id: 8355:LOC108714471
uniprot id: A0A1L8GNG4
uniprot id: A0A8J1MXI5
uniprot id: A0A8J1MYP1
uniprot id: A0A8J1MZ84
uniprot id: A0A8J1N001
names: Similarity
messages: Belongs to the Luc7 family.

8355:LOC108698463
gene id: 8355:LOC108698463
uniprot id: A0A1L8HTZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:glrx.L
gene id: 8355:glrx.L
uniprot id: Q6P7J6
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

8355:brf1.L
gene id: 8355:brf1.L
uniprot id: Q63ZQ0
names: Similarity
messages: Belongs to the TFIIB family.

8355:usp9x.L
gene id: 8355:usp9x.L
uniprot id: A0A1L8HFA1
uniprot id: A0A8J0UHL7
uniprot id: A0A8J1M9J6
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:zfyve16.L
gene id: 8355:zfyve16.L
uniprot id: A0A1L8I1V2
uniprot id: A0A8J0VFE7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

8355:c4orf48.S
gene id: 8355:c4orf48.S
uniprot id: A0A1L8HKN6
names: Subcellular Location Annotation
messages: Secreted

8355:sdhd.S
gene id: 8355:sdhd.S
uniprot id: Q6AZR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b560 composed of sdhc and sdhd.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

8355:gdf9.S
gene id: 8355:gdf9.S
uniprot id: A0A1L8GV93
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

8355:slc7a4.L
gene id: 8355:slc7a4.L
uniprot id: Q6NRJ1
names: Subcellular Location Annotation
messages: Membrane

8355:lsm12.L
gene id: 8355:lsm12.L
uniprot id: Q6GP89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LSM12 family.
messages: Cytoplasm
messages: Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein.

8355:rad54l2.L
gene id: 8355:rad54l2.L
uniprot id: A0A1L8GPA6
uniprot id: A0A8J1MXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

8355:clca2.L
gene id: 8355:clca2.L
uniprot id: A0A1L8GLL0
names: Similarity
messages: Belongs to the CLCR family.

8355:mgat2.L
gene id: 8355:mgat2.L
uniprot id: Q6NTL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

8355:urm1.S
gene id: 8355:urm1.S
uniprot id: A0A8J0TQW3
uniprot id: A0A8J1LMT3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108718537
gene id: 8355:LOC108718537
uniprot id: A0A8J1KY91
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

8355:lpar6.S
gene id: 8355:lpar6.S
uniprot id: A0A1L8H9P7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108710362
gene id: 8355:LOC108710362
uniprot id: A0A8J1MNY5
names: Subcellular Location Annotation
messages: Membrane

8355:dhrs7c.S
gene id: 8355:dhrs7c.S
uniprot id: A0A1L8EN23
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:wdr24.L
gene id: 8355:wdr24.L
uniprot id: A0A8J1LQC5
uniprot id: Q7ZX22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Belongs to the WD repeat WDR24 family.
messages: Lysosome membrane
messages: Probably part of the GATOR complex.

8355:LOC121395648
gene id: 8355:LOC121395648
uniprot id: A0A1L8FNY7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108696590
gene id: 8355:LOC108696590
uniprot id: A0A1L8FMG1
uniprot id: A0A8J0TBN8
uniprot id: A0A8J1L6Y6
uniprot id: A0A8J1L9L5
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

8355:LOC121400415
gene id: 8355:LOC121400415
uniprot id: A0A8J1MCX4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108715050
gene id: 8355:LOC108715050
uniprot id: A0A1L8I050
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

8355:XB5838589.L
gene id: 8355:XB5838589.L
uniprot id: A0A8J0US04
uniprot id: A0A8J1MHK6
uniprot id: A0A8J1MJJ0
uniprot id: Q3KQ58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108710656
gene id: 8355:LOC108710656
uniprot id: A0A1L8H3N4
uniprot id: A0A8J1MNJ2
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:LOC108713916
gene id: 8355:LOC108713916
uniprot id: A0A1L8GJR8
uniprot id: A0A8J0V0N4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:gmpr.L
gene id: 8355:gmpr.L
uniprot id: A0A1L8FY48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

8355:acbd5.L
gene id: 8355:acbd5.L
uniprot id: A0A1L8FVG8
uniprot id: A0A8J0VHT1
uniprot id: A0A8J1KYW1
uniprot id: A0A8J1KYW6
uniprot id: Q641E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity).
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

8355:LOC108711598
gene id: 8355:LOC108711598
uniprot id: A0A8J0UT13
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

8355:ppm1f.S
gene id: 8355:ppm1f.S
uniprot id: A0A8J0UCS3
uniprot id: A0A8J1M3G1
names: Similarity
messages: Belongs to the PP2C family.

8355:LOC108710625
gene id: 8355:LOC108710625
uniprot id: A0A1L8H1X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108705414
gene id: 8355:LOC108705414
uniprot id: A0A8J0U7E4
names: Subcellular Location Annotation
messages: Membrane

8355:incenp.S
gene id: 8355:incenp.S
uniprot id: A0A8J0V8S4
uniprot id: Q32N93
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the INCENP family.
messages: Chromosome
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts (via C-terminus) with aurkb (via N-terminus and kinase domain). Interacts (via N-terminus) with birc5.1, birc5.2, cdca8 and cdca9. Interacts with mtus1 (By similarity).
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs aurkb/aurora-B toward substrates near microtubules. Activates aurkb.
messages: Midbody
messages: Nucleus
messages: Originally predicted to contain a coiled coil domain but shown to contain a stable SAH domain instead.
messages: The INbox mediates interaction with aurkb/aurora-B.
messages: The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric.
messages: centromere
messages: kinetochore
messages: spindle

8355:LOC496283
gene id: 8355:LOC496283
uniprot id: A0A8J1L3I9
uniprot id: Q5I053
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:LOC108698976
gene id: 8355:LOC108698976
uniprot id: A0A8J1LHP2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:arhgef7.S
gene id: 8355:arhgef7.S
uniprot id: A0A8J0UL31
uniprot id: A0A8J1MBI3
uniprot id: A0A8J1MBI5
uniprot id: A0A8J1MBI7
uniprot id: A0A8J1MBV3
uniprot id: A0A8J1MBV9
uniprot id: A0A8J1MCH7
uniprot id: A0A8J1MCI4
uniprot id: A0A8J1MDA1
uniprot id: A0A8J1MDA7
names: Subcellular Location Annotation
messages: lamellipodium

8355:tom1.S
gene id: 8355:tom1.S
uniprot id: Q6DDZ2
names: Similarity
messages: Belongs to the TOM1 family.

8355:pex5.S
gene id: 8355:pex5.S
uniprot id: A0A1L8FDW4
uniprot id: A0A8J0TE97
uniprot id: A0A8J0TEX0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
messages: Cytoplasm
messages: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with pex7. Interaction with pex7 only takes place when pex7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. Pex7 along with PTS2-containing cargo proteins are then translocated through the pex13-pex14 docking complex together with pex5.
messages: Interacts (via WxxxF/Y and LVxEF motifs) with pex14; promoting translocation through the pex13-pex14 docking complex (PubMed:35931083). Interacts with pex7, promoting peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal (By similarity).
messages: Membrane
messages: Monoubiquitinated at Cys-11 by pex2 during pex5 passage through the retrotranslocation channel (By similarity). Cys-11 monoubiquitination acts as a recognition signal for the pex1-pex6 complex and is required for pex5 extraction and export from peroxisomes (PubMed:35931083). When pex5 recycling is compromised, polyubiquitinated by pex10 during its passage through the retrotranslocation channel, leading to its degradation (PubMed:35931083).
messages: Peroxisome matrix
messages: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:35931083). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the pex13-pex14 docking complex along with cargo proteins (PubMed:35931083). Pex5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:35931083).
messages: The TPR repeats mediate interaction with proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type).
messages: The WxxxF/Y motifs mediate interaction with pex14, promoting association with the pex13-pex14 docking complex.
messages: The amphipathic helix 1 and 2 (AH1 and AH2, respectively) are required for pex5 retrotranslocation and recycling. AH2 mediates interaction with lumenal side of the pex2-pex10-pex12 ligase complex, while AH1 is required for extraction from peroxisomal membrane by the pex1-pex6 AAA ATPase complex.
messages: cytosol

8355:fga.L
gene id: 8355:fga.L
uniprot id: A0A1L8HU96
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

8355:lypd6b.L
gene id: 8355:lypd6b.L
uniprot id: A0A1L8EVU3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:pebp1.1.L
gene id: 8355:pebp1.1.L
uniprot id: A0A1L8I192
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

8355:birc2.L
gene id: 8355:birc2.L
uniprot id: A0A1L8HJ69
uniprot id: A0A8J0UC89
uniprot id: Q6DDY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

8355:fabp3.L
gene id: 8355:fabp3.L
uniprot id: Q6PGR8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8355:LOC108710363
gene id: 8355:LOC108710363
uniprot id: A0A8J1MN14
uniprot id: A0A8J1MNX4
uniprot id: A0A8J1MNZ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:dnaja4.1.L
gene id: 8355:dnaja4.1.L
uniprot id: A0A1L8HZM9
uniprot id: Q7SZ03
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108695851
gene id: 8355:LOC108695851
uniprot id: A0A1L8FMC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:krt57.L
gene id: 8355:krt57.L
uniprot id: P02537
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Heterotetramer of two type I and two type II keratins.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

8355:copz1.S
gene id: 8355:copz1.S
uniprot id: A0AUT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

8355:LOC121399532
gene id: 8355:LOC121399532
uniprot id: A0A8J1M480
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108696733
gene id: 8355:LOC108696733
uniprot id: A0A1L8FNC7
uniprot id: A0A8J0TBS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

8355:lin28b.S
gene id: 8355:lin28b.S
uniprot id: A0A1L8G2U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

8355:LOC108701112
gene id: 8355:LOC108701112
uniprot id: A0A1L8EUE3
names: Subcellular Location Annotation
messages: Membrane

8355:hnrnpa1.L
gene id: 8355:hnrnpa1.L
uniprot id: Q6IP29
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:impdh2.S
gene id: 8355:impdh2.S
uniprot id: A0A8J1MZF9
uniprot id: Q7ZYP7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

8355:LOC108709084
gene id: 8355:LOC108709084
uniprot id: A0A1L8H628
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108696503
gene id: 8355:LOC108696503
uniprot id: A0A8J0T2E1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:adgrf1.L
gene id: 8355:adgrf1.L
uniprot id: A0A1L8GC24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:cdv3.L
gene id: 8355:cdv3.L
uniprot id: A0A8J0VHX9
uniprot id: A4PB26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDV3 family.
messages: Cytoplasm

8355:LOC108710804
gene id: 8355:LOC108710804
uniprot id: A0A1L8GWN6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:c11orf58.S
gene id: 8355:c11orf58.S
uniprot id: Q6DDU5
names: Similarity
messages: Belongs to the SMAP family.

8355:creld2.S
gene id: 8355:creld2.S
uniprot id: A0A8J0UUP2
uniprot id: Q5XH36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRELD family.
messages: Endoplasmic reticulum
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Possible role in neuronal acetylcholine receptor transport.
messages: Secreted

8355:ddost.S
gene id: 8355:ddost.S
uniprot id: Q6GNR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).

8355:slc6a4l.S
gene id: 8355:slc6a4l.S
uniprot id: A0A8J0U5C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:kremen2.L
gene id: 8355:kremen2.L
uniprot id: A0A1L8EYY0
uniprot id: A0A8J0TWF4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108701568
gene id: 8355:LOC108701568
uniprot id: A0A1L8EXV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSMST1 family.
messages: Membrane

8355:LOC108708426
gene id: 8355:LOC108708426
uniprot id: A0A1L8HGX2
names: Similarity
messages: Belongs to the IUNH family.

8355:not.S
gene id: 8355:not.S
uniprot id: A0A1L8HKC2
uniprot id: B7ZPL0
uniprot id: Q06615
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By activin, derriere, fgf2/bFGF and wnt8. Repressed by bmp4/dvr-4.
messages: Expressed both maternally and zygotically. Expression increases markedly at the mid-blastula transition (MBT) and peaks at the onset of gastrulation before declining rapidly during the gastrula stages. Another decrease in expression levels occurs towards the end of the neurula stages, although expression is retained into the late tailbud stages.
messages: Expressed throughout the embryo during pre-gastrula stages. Localized to the dorsal lip of the blastopore (Spemann organizer) during early gastrulation, after which expression continues in tissues derived from the organizer. Expressed in the notochord during mid-gastrulation. During neurulation, expressed in the notochord, archenteron roof and the prospective floor plate. Also expressed in the region that will become the epiphysis, the pineal body precursor. By the early tailbud stages, expression is limited to posterior notochord and floor plate before becoming restricted to the tip of the tail in the tadpole.
messages: Nucleus
messages: Transcriptional repressor. Plays a fundamental role in notochord formation, acting within the mesodermal region.

8355:LOC108703970
gene id: 8355:LOC108703970
uniprot id: A0A8J1LT79
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:upf1.L
gene id: 8355:upf1.L
uniprot id: A0A1L8HWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

8355:nr3c2.L
gene id: 8355:nr3c2.L
uniprot id: A0A8J0UAT3
uniprot id: Q66J29
names: Subcellular Location Annotation
messages: Nucleus

8355:tmem203.S
gene id: 8355:tmem203.S
uniprot id: Q6GNX5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Involved in the regulation of cellular calcium homeotasis.

8355:hspe1.L
gene id: 8355:hspe1.L
uniprot id: Q6NUG0
names: Similarity
messages: Belongs to the GroES chaperonin family.

8355:upk1b.L
gene id: 8355:upk1b.L
uniprot id: A0A1L8HCA9
uniprot id: Q7SYP7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

8355:chia.S
gene id: 8355:chia.S
uniprot id: A0A1L8H6V7
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

8355:fcn1.L
gene id: 8355:fcn1.L
uniprot id: Q7ZT75
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ficolin lectin family.
messages: Homotrimer (By similarity). May form higher-order oligomers (PubMed:12679857).
messages: May function in innate immunity through activation of the lectin complement pathway (By similarity). Binds to GalNAc and GlcNAc carbohydrate moieties (PubMed:12679857).
messages: N-glycosylated.
messages: Secreted
messages: Strongly expressed in spleen, liver and heart. Also detected at lower levels in lung.
messages: The fibrinogen C-terminal domain mediates binding to carbohydrates.

8355:LOC121394345
gene id: 8355:LOC121394345
uniprot id: Q8UW71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:dusp5.S
gene id: 8355:dusp5.S
uniprot id: Q6GLJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

8355:efemp1.S
gene id: 8355:efemp1.S
uniprot id: A0A1L8G1J4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:snx18.S
gene id: 8355:snx18.S
uniprot id: Q5XGZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

8355:LOC108699562
gene id: 8355:LOC108699562
uniprot id: A0A1L8FB52
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

8355:capn2.S
gene id: 8355:capn2.S
uniprot id: A0A1L8G117
uniprot id: A0A8J0VEB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8355:LOC108713153
gene id: 8355:LOC108713153
uniprot id: A0A1L8GUE8
uniprot id: A0A8J0UWN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

8355:jmjd6.L
gene id: 8355:jmjd6.L
uniprot id: Q6GND3
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JMJD6 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of u2af2/u2af65, affecting the pre-mRNA splicing activity of u2af2/u2af65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with brd4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. Demethylates other arginine methylated-proteins such as esr1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation (By similarity).
messages: Hydroxylates its own N-terminus; hydroxylation is required for homooligomerization.
messages: The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus.
messages: nucleolus
messages: nucleoplasm

8355:gprc5cl2.L
gene id: 8355:gprc5cl2.L
uniprot id: A0A1L8FNP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:immt.L
gene id: 8355:immt.L
uniprot id: A0A1L8HT59
uniprot id: A0A8J0TFE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

8355:LOC108700673
gene id: 8355:LOC108700673
uniprot id: A0A1L8F3U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8355:LOC108702659
gene id: 8355:LOC108702659
uniprot id: A0A1L8ELV2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8355:tmem168.S
gene id: 8355:tmem168.S
uniprot id: Q7ZY86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Nucleus membrane
messages: Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A.

8355:tmem263.S
gene id: 8355:tmem263.S
uniprot id: Q5U4X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: May play a role in bone development.
messages: Membrane

8355:krt55.L
gene id: 8355:krt55.L
uniprot id: Q98UJ1
names: Similarity
messages: Belongs to the intermediate filament family.

8355:LOC108710409
gene id: 8355:LOC108710409
uniprot id: A0A8J1MJB4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108700428
gene id: 8355:LOC108700428
uniprot id: A0A8J0TI50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

8355:MGC85357
gene id: 8355:MGC85357
uniprot id: Q66KX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8355:idh1.L
gene id: 8355:idh1.L
uniprot id: Q640H5
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

8355:arhgap21.S
gene id: 8355:arhgap21.S
uniprot id: Q6DFG0
names: Function
names: Subcellular Location Annotation
messages: Cell junction
messages: Cytoplasmic vesicle membrane
messages: GTPase-activating protein (GAP) for rhoa and cdc42.
messages: Golgi apparatus membrane
messages: cytoskeleton

8355:fgg.S
gene id: 8355:fgg.S
uniprot id: A0A1L8HLM6
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

8355:tatdn2.S
gene id: 8355:tatdn2.S
uniprot id: A0A1L8GHK9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

8355:mknk1.S
gene id: 8355:mknk1.S
uniprot id: A0A8J1MZB4
uniprot id: Q9YGW0
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).

8355:prickle1.L
gene id: 8355:prickle1.L
uniprot id: Q90WV2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Regulates the polarized assembly of fibronectrin on the surface of the mesoderm during gastrulation. Essential for gastrulation cell movements, cooperating with dvl2/dsh to activate jnk. Acts together with tes to control axial elongation.
messages: Belongs to the prickle / espinas / testin family.
messages: Cell membrane
messages: Expressed both maternally and zygotically. Zygotic expression begins at the onset of gastrulation (stage 10), and steadily increases until tadpole stage (stage 30).
messages: Expressed in the dorsal marginal zone of early gastrulae (stage 10). As gastrulation proceeds, expression expands to include the lateral and ventral marginal zones, excluding the few rows of cells above the blastopore lip. Expression moves dorsally with gastrulation cell movements, and by the end of gastrulation expression is seen in dorsal mesoderm and posterior but not anterior neural ectoderm. Expression becomes down-regulated in mesoderm but remains strong in posterior ectoderm through the neurula stages. During tailbud stages, expressed in the pronephric duct, tailbud, tailtip and forming somites. In the most posterior regions, expressed in notochord and in the floorplate of the neural tube with weak expression in the roofplate. At stage 30, expressed in a complex pattern in the head including strong expression in the lens and otic vesicle.
messages: Interacts with dvl2/dsh and mapk8/jnk1.

8355:LOC108696502
gene id: 8355:LOC108696502
uniprot id: A0A1L8FLU0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:LOC121397756
gene id: 8355:LOC121397756
uniprot id: A0A1L8F3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:eif3h.L
gene id: 8355:eif3h.L
uniprot id: A0A1L8FZW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8355:fam174c.L
gene id: 8355:fam174c.L
uniprot id: A0A1L8HX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

8355:LOC108707553
gene id: 8355:LOC108707553
uniprot id: A0A8J1M9W9
uniprot id: A0A8J1MA65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8355:LOC108706527
gene id: 8355:LOC108706527
uniprot id: A0A1L8HKU4
names: Subcellular Location Annotation
messages: Nucleus

8355:qars1.L
gene id: 8355:qars1.L
uniprot id: A0A1L8GQ05
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

8355:nkx6-1.L
gene id: 8355:nkx6-1.L
uniprot id: A5YC48
names: Subcellular Location Annotation
messages: Nucleus

8355:myrfl.L
gene id: 8355:myrfl.L
uniprot id: A0A1L8GYL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

8355:rspo3.L
gene id: 8355:rspo3.L
uniprot id: A0A1L8G886
names: Similarity
messages: Belongs to the R-spondin family.

8355:LOC108698084
gene id: 8355:LOC108698084
uniprot id: A0A1L8F5F0
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

8355:LOC121397982
gene id: 8355:LOC121397982
uniprot id: A0A8J1LU53
names: Subcellular Location Annotation
messages: Membrane

8355:slc35d2.S
gene id: 8355:slc35d2.S
uniprot id: A0A1L8HPC4
names: Subcellular Location Annotation
messages: Membrane

8355:esrp1.S
gene id: 8355:esrp1.S
uniprot id: A0A1L8FTH7
uniprot id: A0A8J0T7A1
uniprot id: A0A8J0T870
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

8355:LOC108702492
gene id: 8355:LOC108702492
uniprot id: A0A1L8EKP1
uniprot id: A0A8J1LX76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

8355:yod1.L
gene id: 8355:yod1.L
uniprot id: Q0IH43
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.

8355:cadm4.S
gene id: 8355:cadm4.S
uniprot id: A0A8J1LDH9
names: Similarity
messages: Belongs to the nectin family.

8355:LOC108710892
gene id: 8355:LOC108710892
uniprot id: A0A1L8GX86
uniprot id: A0A8J0UQ84
names: Subcellular Location Annotation
messages: Cytoplasm

8355:tekt1.L
gene id: 8355:tekt1.L
uniprot id: A0A8J1M774
uniprot id: Q6IP53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

8355:tmem167b.S
gene id: 8355:tmem167b.S
uniprot id: A0A1L8H764
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:gli1.S
gene id: 8355:gli1.S
uniprot id: A0A1L8HA22
uniprot id: A0A8J0UDR0
uniprot id: A0A8J0ULQ2
uniprot id: A0A8J0ULS0
uniprot id: A0A8J0UPM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

8355:LOC108707344
gene id: 8355:LOC108707344
uniprot id: A0A1L8HS40
names: Similarity
messages: Belongs to the UPF0729 family.

8355:meltf.S
gene id: 8355:meltf.S
uniprot id: A0A1L8G3Z9
names: Similarity
messages: Belongs to the transferrin family.

8355:med27.S
gene id: 8355:med27.S
uniprot id: A0A8J0TPR1
uniprot id: Q3B8G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8355:fars2.L
gene id: 8355:fars2.L
uniprot id: A0A8J0VH20
uniprot id: A0A8J0VJP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

8355:lmbr1l.L
gene id: 8355:lmbr1l.L
uniprot id: A0A8J1M544
uniprot id: Q7ZX75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: Dimer (By similarity). Can also form higher oligomers (By similarity).
messages: Endoplasmic reticulum membrane
messages: May play a role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). May act as a LCN1 receptor (By similarity).

8355:polr3f.L
gene id: 8355:polr3f.L
uniprot id: A0A1L8G7I5
uniprot id: A0A8J0VAQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

8355:kiaa2013.L
gene id: 8355:kiaa2013.L
uniprot id: A0A1L8FKW6
uniprot id: A5PKQ9
names: Subcellular Location Annotation
messages: Membrane

8355:treh.L
gene id: 8355:treh.L
uniprot id: A0A1L8FLF9
uniprot id: A0A8J0T8P2
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

8355:LOC108706649
gene id: 8355:LOC108706649
uniprot id: A0A1L8HLK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108717266
gene id: 8355:LOC108717266
uniprot id: A0A1L8GCB7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:LOC108718599
gene id: 8355:LOC108718599
uniprot id: A0A8J1KZ05
names: Subcellular Location Annotation
messages: Nucleus

8355:b3glct.L
gene id: 8355:b3glct.L
uniprot id: A0A8J0UBG3
uniprot id: A0A8J0UDZ2
uniprot id: A0A8J1M4U4
uniprot id: A9JS85
names: Subcellular Location Annotation
messages: Membrane

8355:actr3.S
gene id: 8355:actr3.S
uniprot id: Q801P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:17178911). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:17178911). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the actin family. ARP3 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Nucleus
messages: cytoskeleton

8355:LOC108718411
gene id: 8355:LOC108718411
uniprot id: A0A1L8I3A7
uniprot id: A0A8J0VHE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

8355:gsc2.S
gene id: 8355:gsc2.S
uniprot id: A0A1L8HQD2
uniprot id: A0A8J1M4K9
names: Subcellular Location Annotation
messages: Nucleus

8355:rasgrp1.S
gene id: 8355:rasgrp1.S
uniprot id: A0A1L8EZI4
uniprot id: A0A8J1LNK0
names: Similarity
messages: Belongs to the RASGRP family.

8355:LOC121394464
gene id: 8355:LOC121394464
uniprot id: A0A8J1KXU3
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:emc10.L
gene id: 8355:emc10.L
uniprot id: A5D8P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC10 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.

8355:alox5ap.L
gene id: 8355:alox5ap.L
uniprot id: A0A1L8HIX7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8355:LOC108700556
gene id: 8355:LOC108700556
uniprot id: A0A8J1LNB2
names: Similarity
messages: Belongs to the MAP7 family.

8355:LOC121399037
gene id: 8355:LOC121399037
uniprot id: A0A8J1M0C8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:flad1.L
gene id: 8355:flad1.L
uniprot id: A0A8J0T8N9
uniprot id: A0A8J1LEH5
uniprot id: Q6ING7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.
messages: The molybdenum cofactor biosynthesis protein-like region may not be functional.

8355:sulf2.L
gene id: 8355:sulf2.L
uniprot id: A1L102
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8355:lefty.S
gene id: 8355:lefty.S
uniprot id: Q9DFC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

8355:actr6.L
gene id: 8355:actr6.L
uniprot id: A0A8J0ULE4
uniprot id: A2VDB7
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

8355:cdc25a.L
gene id: 8355:cdc25a.L
uniprot id: A0A1L8FUS6
uniprot id: A0A8J1KVB3
uniprot id: Q640K0
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

8355:LOC108708777
gene id: 8355:LOC108708777
uniprot id: A0A1L8HJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108699505
gene id: 8355:LOC108699505
uniprot id: A0A8J0TLV6
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

8355:LOC121398796
gene id: 8355:LOC121398796
uniprot id: A0A8J1LXD8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108699568
gene id: 8355:LOC108699568
uniprot id: A0A8J0TNV4
names: Subcellular Location Annotation
messages: Membrane

8355:b4galt2.S
gene id: 8355:b4galt2.S
uniprot id: A0A8J0UZ55
uniprot id: B5DE62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:edf1.L
gene id: 8355:edf1.L
uniprot id: Q6GPQ6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable transcriptional coactivator.

8355:LOC108706163
gene id: 8355:LOC108706163
uniprot id: A0A8J1MIU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:bloc1s2.S
gene id: 8355:bloc1s2.S
uniprot id: A0A8J0TER2
uniprot id: A0A8J0TFD2
names: Similarity
messages: Belongs to the BLOC1S2 family.

8355:elf2.L
gene id: 8355:elf2.L
uniprot id: A0A8J1M1H9
uniprot id: A0A8J1M1K4
uniprot id: A0A8J1M3E9
uniprot id: A0A8J1M3H7
uniprot id: Q5XHJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:osbpl2.L
gene id: 8355:osbpl2.L
uniprot id: A0A8J0TSM6
uniprot id: Q8AVL8
names: Similarity
messages: Belongs to the OSBP family.

8355:sec61g.L
gene id: 8355:sec61g.L
uniprot id: A0A1L8FWK5
uniprot id: Q66KU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma (By similarity). Component of the ribosome-associated ER translocon complex (By similarity).
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum and multi-pass membrane protein biogenesis.

8355:pea15.L
gene id: 8355:pea15.L
uniprot id: A0A1L8FCQ0
uniprot id: Q3KPT6
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108716062
gene id: 8355:LOC108716062
uniprot id: A0A1L8GCR4
uniprot id: A0A8J1KQI8
uniprot id: A0A8J1KQJ9
uniprot id: A0A8J1KS56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

8355:adgrb2.L
gene id: 8355:adgrb2.L
uniprot id: A0A1L8HFL5
uniprot id: A0A8J1M8R7
uniprot id: A0A8J1M8S0
uniprot id: A0A8J1M8W9
names: Subcellular Location Annotation
messages: Membrane

8355:spx1.L
gene id: 8355:spx1.L
uniprot id: A0A8J0UPQ5
uniprot id: A0A8J1MI72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

8355:ccdc107.L
gene id: 8355:ccdc107.L
uniprot id: A0A310UDY8
names: Similarity
messages: Belongs to the ric-3 family.

8355:chrna7.L
gene id: 8355:chrna7.L
uniprot id: A0A1L8H099
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:LOC108719682
gene id: 8355:LOC108719682
uniprot id: A0A1L8FRA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

8355:psma1.S
gene id: 8355:psma1.S
uniprot id: Q5XGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

8355:upf1.S
gene id: 8355:upf1.S
uniprot id: Q6GNR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

8355:calm2.L
gene id: 8355:calm2.L
uniprot id: P0DP33
uniprot id: P0DP34
uniprot id: P0DP35
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

8355:tmem126a.L
gene id: 8355:tmem126a.L
uniprot id: A0A1L8HJT0
uniprot id: A0A8J0UAA9
uniprot id: Q4V7T4
names: Subcellular Location Annotation
messages: Membrane

8355:cmtm8.S
gene id: 8355:cmtm8.S
uniprot id: A0A1L8FRH0
names: Subcellular Location Annotation
messages: Membrane

8355:nr2c1.L
gene id: 8355:nr2c1.L
uniprot id: A0A1L8GYD6
uniprot id: Q66J63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus
messages: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity).

8355:lbh.L
gene id: 8355:lbh.L
uniprot id: Q91715
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LBH family.
messages: Cytoplasm
messages: Expressed in anterior neural plate.
messages: Nucleus
messages: Transcriptional activator.

8355:crabp2.S
gene id: 8355:crabp2.S
uniprot id: A0A1L8F4J7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8355:ocm4.1.L
gene id: 8355:ocm4.1.L
uniprot id: Q8AVD4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8355:pde1a.S
gene id: 8355:pde1a.S
uniprot id: A0A8J1LYF6
uniprot id: A0A8J1M0D8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:LOC108704391
gene id: 8355:LOC108704391
uniprot id: A0A8J1KM65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

8355:scube2.S
gene id: 8355:scube2.S
uniprot id: A0A1L8GEE5
uniprot id: A0A8J0V1D1
uniprot id: A0A8J0V5U4
uniprot id: A0A8J1KHY6
uniprot id: A0A8J1KI00
uniprot id: A0A8J1KJS0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:lmx1a.S
gene id: 8355:lmx1a.S
uniprot id: A0A1L8GGE2
names: Subcellular Location Annotation
messages: Nucleus

8355:aco2.S
gene id: 8355:aco2.S
uniprot id: Q6DKB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

8355:gh2.S
gene id: 8355:gh2.S
uniprot id: P12856
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Growth hormone plays an important role in growth control.
messages: Secreted

8355:cct5b
gene id: 8355:cct5b
uniprot id: A0AUT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

8355:cer1.S
gene id: 8355:cer1.S
uniprot id: P70041
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A component of the Nieuwkoop signaling center in the blastula. Expressed transiently in a broad anterior domain of the gastrula, including the anterior endoderm of the Spemann's organizer and more laterally the cardiac primordia. Expression is excluded from the prospective prechordal plate region and the ring of cells that give rise to the trunk-tail mesoderm.
messages: Belongs to the DAN family.
messages: By nodal/nr-1 signaling and wnt8 signaling including the downstream effectors mix-A/mix.1 and siamois acting synergistically with either lhx1/lim1 or otx2. Also by acvr1b/alk4.
messages: Expressed both maternally and zygotically. Zygotic expression increases at stage 10 (early gastrula), continues during gastrula and early neurula stages before rapidly declining during neurulation.
messages: Inhibits wnt, nodal/nr-1 and bmp signaling in the embryo to promote head formation and anterior neural induction. Within the endoderm, acts as an essential mediator of nodal/nr-1-induced cardiogenesis in the overlying mesoderm.
messages: Microinjection of cer1 into blastomeres results in the formation of ectopic heads that contain cyclopic eyes as well as duplicated internal organs such as liver and heart. The heart beats at a rhythm different to that of the primary heart. Based on this phenotype the name 'cerberus' was chosen after a mythological guardian dog with multiple heads.
messages: Secreted
messages: The long chain interacts with nodal/nr-1, bmp4 and wnt8, thereby inhibiting their function. The short chain interacts with nodal/nr-1 but not bmp4 or wnt8.

8355:LOC121399015
gene id: 8355:LOC121399015
uniprot id: A0A1L8HPN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ahcy.L
gene id: 8355:ahcy.L
uniprot id: A0A8J1LQ12
uniprot id: P51893
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (By similarity). Binds copper ions (By similarity).
messages: Cytoplasm
messages: Homotetramer.

8355:stac3.L
gene id: 8355:stac3.L
uniprot id: A0A1L8HI11
names: Subcellular Location Annotation
messages: sarcolemma

8355:dbr1.S
gene id: 8355:dbr1.S
uniprot id: Q7ZWU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function.
messages: Nucleus

8355:LOC108698757
gene id: 8355:LOC108698757
uniprot id: A0A8J0TC52
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

8355:zhx1.L
gene id: 8355:zhx1.L
uniprot id: A0A1L8G021
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

8355:LOC108695903
gene id: 8355:LOC108695903
uniprot id: A0A8J1L7K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

8355:acot13.S
gene id: 8355:acot13.S
uniprot id: A9ULW5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

8355:MGC108429.L
gene id: 8355:MGC108429.L
uniprot id: A0A8J0THW5
uniprot id: Q5U502
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

8355:myo1c.S
gene id: 8355:myo1c.S
uniprot id: A0A8J0UGQ5
uniprot id: A0MP03
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed during oogenesis and eggs. Up-regulated by polyadenylation during meiotic maturation (at protein level).
messages: Interacts (via its IQ motifs) with calmodulin.
messages: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Involved in egg activation by coupling dynamic actin to membrane.
messages: Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).
messages: stereocilium membrane

8355:cxcl13.L
gene id: 8355:cxcl13.L
uniprot id: A0A1L8HVE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8355:LOC121397296
gene id: 8355:LOC121397296
uniprot id: A0A8J1LK01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:atp1b1.S
gene id: 8355:atp1b1.S
uniprot id: Q91580
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8355:kcnq1.L
gene id: 8355:kcnq1.L
uniprot id: A0A8J0UXJ5
uniprot id: P70057
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft
messages: Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity).
messages: Tetramer. Heterotetramer with KCNE1; targets to the membrane raft. Interacts (via C-terminus) with CALM; forms an heterotetramer in a calcium-independent manner. Interacts with KCNE2; form a heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current. Interacts with KCNE3; alters membrane raft localization. Interacts with KCNE4; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity. Interacts with KCNE5; impairs KCNQ1 localization in lipid rafts and only conducts current upon strong and continued depolarization.
messages: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
messages: The segment S6 is involved in the inhibition of voltage-gated potassium channel activity by KCNE4.

8355:LOC108716159
gene id: 8355:LOC108716159
uniprot id: A0A1L8G8T6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108707545
gene id: 8355:LOC108707545
uniprot id: A0A8J1MAP1
names: Similarity
messages: Belongs to the formin homology family.

8355:LOC495489
gene id: 8355:LOC495489
uniprot id: Q5U4J1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8355:LOC121398344
gene id: 8355:LOC121398344
uniprot id: A0A8J1LVQ1
names: Subcellular Location Annotation
messages: Nucleus

8355:marchf3.S
gene id: 8355:marchf3.S
uniprot id: Q0IH10
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle membrane
messages: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
messages: Early endosome membrane
messages: The RING-CH-type zinc finger domain is required for E3 ligase activity.

8355:nrp2.L
gene id: 8355:nrp2.L
uniprot id: A0A1L8EWZ0
uniprot id: A0A8J0TWR1
uniprot id: A0A8J0TY59
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108701734
gene id: 8355:LOC108701734
uniprot id: A0A8J0TXX3
uniprot id: A0A8J1LTP0
uniprot id: A0A8J1LUG9
uniprot id: A0A8J1LVD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:ptprk.L
gene id: 8355:ptprk.L
uniprot id: A0A8J1KNF1
uniprot id: A0A8J1KNF5
uniprot id: A0A8J1KNF7
uniprot id: A0A8J1KNG0
uniprot id: A0A8J1KNG2
uniprot id: A0A8J1KNG7
uniprot id: A0A8J1KNG8
uniprot id: A0A8J1KNH2
uniprot id: A0A8J1KNH6
uniprot id: A0A8J1KQ37
uniprot id: A0A8J1KQ42
uniprot id: A0A8J1KQ47
uniprot id: A0A8J1KRJ6
uniprot id: A0A8J1KRK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

8355:LOC445838
gene id: 8355:LOC445838
uniprot id: A0A1L8F054
uniprot id: A0A8J0TPI2
names: Subcellular Location Annotation
messages: Cytoplasm

8355:sntg1.L
gene id: 8355:sntg1.L
uniprot id: A0A1L8FYY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

8355:tspan4.S
gene id: 8355:tspan4.S
uniprot id: A0A1L8FGZ4
uniprot id: A0A1L8FH16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC108708001
gene id: 8355:LOC108708001
uniprot id: A0A8J0U5X6
uniprot id: A0A8J0UCV4
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

8355:tsen34.L
gene id: 8355:tsen34.L
uniprot id: A0A1L8FNM0
uniprot id: A0A8J0TCF6
uniprot id: A0A8J1L7R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

8355:tprg1l.L
gene id: 8355:tprg1l.L
uniprot id: Q5XGQ8
names: Similarity
messages: Belongs to the TPRG1 family.

8355:ndufa2.L
gene id: 8355:ndufa2.L
uniprot id: A0A1L8GWZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8355:LOC108710439
gene id: 8355:LOC108710439
uniprot id: A0A8J1MJD7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:septin11.S
gene id: 8355:septin11.S
uniprot id: A0A8J1LQ52
uniprot id: A0A8J1LQ55
uniprot id: A0A8J1LR27
uniprot id: A0A8J1LRK3
uniprot id: Q66J62
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

8355:LOC121394357
gene id: 8355:LOC121394357
uniprot id: A0A8J1KWH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:fbxl17.L
gene id: 8355:fbxl17.L
uniprot id: B1H1X1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the FBXL17 family.
messages: Cytoplasm
messages: Expressed in the neuro-ectoderm of embryos.
messages: Impaired nervous system development caused by inability to eliminate aberrant BTB domain-containing protein dimers.
messages: Nucleus
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL17). Interacts with BTB domain-containing proteins; specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition.
messages: Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (By similarity). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (PubMed:30190310).

8355:cebpa.S
gene id: 8355:cebpa.S
uniprot id: Q6INV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

8355:gcgr.L
gene id: 8355:gcgr.L
uniprot id: Q8UVY5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108713213
gene id: 8355:LOC108713213
uniprot id: A0A1L8GUW3
names: Subcellular Location Annotation
messages: Membrane

8355:bmpr1b.S
gene id: 8355:bmpr1b.S
uniprot id: A0A1L8HME1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8355:dpm3.L
gene id: 8355:dpm3.L
uniprot id: A0A1L8FDF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

8355:nudc.S
gene id: 8355:nudc.S
uniprot id: Q640C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

8355:rspo2.L
gene id: 8355:rspo2.L
uniprot id: B7ZQ42
uniprot id: Q5UE90
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity). Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (PubMed:15469841). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity).
messages: Belongs to the R-spondin family.
messages: Binds heparin.
messages: By Wnt proteins.
messages: Expressed from early gastrula stage and remains constant throughout neurulation and organogenesis. Expressed throughout the ectoderm of early gastrula. During gastrulation, it is detected in the marginal zone in both deep and superficial layers but is excluded from the Speemann organizer. At late gastrula, it persists in lateral plate mesoderm and becomes detectable in the anterior neural plate. At stage 15, it is expressed in 2 longitudinal stripes along the neural plate, in the anterior neural plate, and in lateral and posterior mesoderm. At tailbud stage, it is restricted in several regions of the brain, including diencephalon and midbrain-hindbrain boundary, pronephros and dorsal neural tube. Also detected in the dorsal- and ventral-most portions of somites, the drosal fin and the proctodeum. Expression in the brain of late tadpoles is mainly restricted to diencephalon, including the zona limitans intrahalamica.
messages: Secreted
messages: The FU repeat is required for activation and stabilization of beta-catenin.

8355:psmc2.L
gene id: 8355:psmc2.L
uniprot id: A9ULV8
uniprot id: P46472
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

8355:LOC121394107
gene id: 8355:LOC121394107
uniprot id: A0A8J1KTG7
names: Subcellular Location Annotation
messages: interphotoreceptor matrix

8355:lefty.L
gene id: 8355:lefty.L
uniprot id: Q9DFC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

8355:hgs.L
gene id: 8355:hgs.L
uniprot id: A0A8J0TJ52
uniprot id: Q7ZX24
names: Subcellular Location Annotation
messages: Early endosome membrane

8355:LOC108701931
gene id: 8355:LOC108701931
uniprot id: A0A8J0TWP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:glp1r.L
gene id: 8355:glp1r.L
uniprot id: A0A8J0VAB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:bysl.S
gene id: 8355:bysl.S
uniprot id: Q6INQ1
names: Similarity
messages: Belongs to the bystin family.

8355:lrp8.S
gene id: 8355:lrp8.S
uniprot id: A0A1L8GFY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108711028
gene id: 8355:LOC108711028
uniprot id: A0A1L8GY45
uniprot id: A0A8J0UI90
uniprot id: A0A8J0UTV9
uniprot id: A0A8J1MLB8
names: Subcellular Location Annotation
messages: Nucleus

8355:mfsd5.S
gene id: 8355:mfsd5.S
uniprot id: A0A1L8HA69
uniprot id: Q08B29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
messages: Membrane

8355:rps6kb1.L
gene id: 8355:rps6kb1.L
uniprot id: A0A1L8HFU6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8355:prcp.L
gene id: 8355:prcp.L
uniprot id: A0A1L8HJS7
names: Similarity
messages: Belongs to the peptidase S28 family.

8355:sgcb.S
gene id: 8355:sgcb.S
uniprot id: A0A1L8HL87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

8355:ino80d.L
gene id: 8355:ino80d.L
uniprot id: A0A1L8EX02
names: Subcellular Location Annotation
messages: Nucleus

8355:nagk.L
gene id: 8355:nagk.L
uniprot id: B4F6R2
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

8355:lsm8.S
gene id: 8355:lsm8.S
uniprot id: Q6NTS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

8355:LOC108719900
gene id: 8355:LOC108719900
uniprot id: A0A1L8FQZ7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:otog.L
gene id: 8355:otog.L
uniprot id: A0A8J1MVT7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108706979
gene id: 8355:LOC108706979
uniprot id: A0A1L8HPC6
uniprot id: A0A8J0U1G1
uniprot id: A0A8J0U8I0
uniprot id: A0A8J0U9I2
uniprot id: A0A8J1M313
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

8355:LOC121402245
gene id: 8355:LOC121402245
uniprot id: A0A8J1MSH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC121402247
gene id: 8355:LOC121402247
uniprot id: A0A8J1MSM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:ints7.S
gene id: 8355:ints7.S
uniprot id: A0JMW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

8355:clptm1l.S
gene id: 8355:clptm1l.S
uniprot id: A0A1L8FRT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

8355:camk2b.L
gene id: 8355:camk2b.L
uniprot id: A0A1L8H1N2
uniprot id: A0A1L8H1R7
uniprot id: A0A8J0UF87
uniprot id: A0A8J0UF95
uniprot id: A0A8J0UN74
uniprot id: A0A8J0UN79
uniprot id: A0A8J0UR64
uniprot id: A0A8J0UR70
uniprot id: A0A8J1MGS5
uniprot id: A0A8J1MGS8
uniprot id: A0A8J1MGT0
uniprot id: A0A8J1MGT4
uniprot id: A0A8J1MHC0
uniprot id: A0A8J1MHC5
uniprot id: A0A8J1MHD0
uniprot id: A0A8J1MHQ6
uniprot id: A0A8J1MHR2
uniprot id: A0A8J1MIN1
uniprot id: A0A8J1MIN7
uniprot id: Q6AX64
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8355:LOC108709156
gene id: 8355:LOC108709156
uniprot id: A0A8J0ULV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:gpc1.L
gene id: 8355:gpc1.L
uniprot id: A0A1L8GAW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: extracellular space

8355:slc7a1.L
gene id: 8355:slc7a1.L
uniprot id: A0A1L8HIZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

8355:LOC121398070
gene id: 8355:LOC121398070
uniprot id: A0A1L8G0S2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108708599
gene id: 8355:LOC108708599
uniprot id: A0A8J0U8I9
uniprot id: A0A8J0UFA2
uniprot id: A0A8J1MA50
names: Similarity
messages: Belongs to the centaurin gamma-like family.

8355:btg5.3.S
gene id: 8355:btg5.3.S
uniprot id: A0A8J1LFY9
names: Similarity
messages: Belongs to the BTG family.

8355:gpx1.L
gene id: 8355:gpx1.L
uniprot id: A0A8J0Q3V1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

8355:LOC108696550
gene id: 8355:LOC108696550
uniprot id: A0A1L8FM22
names: Caution
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:hspb1.L
gene id: 8355:hspb1.L
uniprot id: Q66KY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: spindle

8355:akap9.S
gene id: 8355:akap9.S
uniprot id: A0A8J0VJJ0
uniprot id: A0A8J0VJJ7
uniprot id: A0A8J0VLL9
uniprot id: A0A8J0VLM4
uniprot id: A0A8J0VLY6
uniprot id: A0A8J0VLZ2
uniprot id: A0A8J0VLZ7
uniprot id: A0A8J0VMP9
uniprot id: A0A8J0VMQ4
uniprot id: A0A8J0VQ73
uniprot id: A0A8J0VQ75
names: Subcellular Location Annotation
messages: centrosome

8355:hoxc12.S
gene id: 8355:hoxc12.S
uniprot id: A0A1L8HA51
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108697283
gene id: 8355:LOC108697283
uniprot id: A0A8J1LDQ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:shq1.L
gene id: 8355:shq1.L
uniprot id: B3DLL9
names: Similarity
messages: Belongs to the SHQ1 family.

8355:agt.L
gene id: 8355:agt.L
uniprot id: A0A1L8G7P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

8355:XB5789557.L
gene id: 8355:XB5789557.L
uniprot id: Q7T0T5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:mgat1.L
gene id: 8355:mgat1.L
uniprot id: Q2TAG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

8355:arrdc4.S
gene id: 8355:arrdc4.S
uniprot id: A0A1L8GSG4
names: Similarity
messages: Belongs to the arrestin family.

8355:LOC121399929
gene id: 8355:LOC121399929
uniprot id: A0A8J1M954
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:LOC494784
gene id: 8355:LOC494784
uniprot id: Q63ZL1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:acad9.S
gene id: 8355:acad9.S
uniprot id: Q6DDF2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8355:slc16a1.S
gene id: 8355:slc16a1.S
uniprot id: Q7ZYH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

8355:gpr135.L
gene id: 8355:gpr135.L
uniprot id: A0A1L8FA93
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:ldlr.L
gene id: 8355:ldlr.L
uniprot id: Q99087
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Interacts with ldlrap1.
messages: Late endosome
messages: Lysosome
messages: The NPXY motif mediates the interaction with ldlrap1.
messages: clathrin-coated pit

8355:dtx2.S
gene id: 8355:dtx2.S
uniprot id: A0A1L8H8A0
uniprot id: A0A8J0UHS3
uniprot id: Q801Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

8355:calhm2.L
gene id: 8355:calhm2.L
uniprot id: A0A1L8FJ92
uniprot id: A0A8J1L4X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

8355:ern1.S
gene id: 8355:ern1.S
uniprot id: A0A1L8END6
uniprot id: A0A8J0TZZ9
uniprot id: A0A8J0U039
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:uqcc3.L
gene id: 8355:uqcc3.L
uniprot id: Q2KP58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex).
messages: Belongs to the UQCC3 family.
messages: Mitochondrion inner membrane
messages: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology.

8355:b4galt3.S
gene id: 8355:b4galt3.S
uniprot id: A0A1L8F4Z7
uniprot id: Q6NU80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:yy1.L
gene id: 8355:yy1.L
uniprot id: Q6DDI1
uniprot id: Q91745
names: Similarity
messages: Belongs to the YY transcription factor family.

8355:coq8a.L
gene id: 8355:coq8a.L
uniprot id: A0A8J0V8L5
uniprot id: A1A5J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Membrane
messages: Mitochondrion

8355:ccnt2.L
gene id: 8355:ccnt2.L
uniprot id: A0A1L8EVJ2
uniprot id: A0A8J0TUN1
uniprot id: A0A8J0TVT8
names: Similarity
messages: Belongs to the cyclin family.

8355:ttyh3.S
gene id: 8355:ttyh3.S
uniprot id: A0A8J1LVX8
uniprot id: A0A8J1LXB0
uniprot id: Q6GPA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.
messages: Probable large-conductance Ca(2+)-activated chloride channel.

8355:hmgb1.L
gene id: 8355:hmgb1.L
uniprot id: Q7SZ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome
messages: Secreted

8355:tbx18.S
gene id: 8355:tbx18.S
uniprot id: A0A1L8G3B1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:mpp2.S
gene id: 8355:mpp2.S
uniprot id: A0A1L8EL53
uniprot id: A0A8J1LY44
uniprot id: A0A8J1LYE4
uniprot id: A0A8J1M0C6
names: Similarity
messages: Belongs to the MAGUK family.

8355:LOC108711011
gene id: 8355:LOC108711011
uniprot id: A0A1L8GY10
uniprot id: A0A8J1MKA0
uniprot id: A0A8J1ML37
uniprot id: A0A8J1MMB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

8355:bmp15.L
gene id: 8355:bmp15.L
uniprot id: A0A1L8F6L5
names: Similarity
messages: Belongs to the TGF-beta family.

8355:hsph1.L
gene id: 8355:hsph1.L
uniprot id: Q6GPQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

8355:gna14.S
gene id: 8355:gna14.S
uniprot id: Q32NN4
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

8355:scamp1.S
gene id: 8355:scamp1.S
uniprot id: A0A1L8HRG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

8355:zdhhc12.L
gene id: 8355:zdhhc12.L
uniprot id: A0A1L8H0A3
uniprot id: A0A8J0UQY5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:eif1ax.L
gene id: 8355:eif1ax.L
uniprot id: Q6NU16
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

8355:LOC121401182
gene id: 8355:LOC121401182
uniprot id: A0A1L8H2A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cers5.L
gene id: 8355:cers5.L
uniprot id: A0A8J1M592
uniprot id: Q8QGA3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

8355:ndufb8.S
gene id: 8355:ndufb8.S
uniprot id: A0A1L8FF73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8355:eef1b2.L
gene id: 8355:eef1b2.L
uniprot id: P30151
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
messages: Phosphorylation affects the GDP/GTP exchange rate.

8355:jmy.S
gene id: 8355:jmy.S
uniprot id: A0A8J1M436
names: Subcellular Location Annotation
messages: Membrane

8355:naa35.S
gene id: 8355:naa35.S
uniprot id: A0A1L8HP96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

8355:ism2.L
gene id: 8355:ism2.L
uniprot id: A0A1L8F9D1
uniprot id: A0A8J0THZ1
names: Similarity
messages: Belongs to the isthmin family.

8355:gjb3.S
gene id: 8355:gjb3.S
uniprot id: Q8QFX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:ogfrl1.L
gene id: 8355:ogfrl1.L
uniprot id: A0A8J0U3F2
uniprot id: A0A8J1KP30
uniprot id: A0A8J1KP36
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

8355:LOC108710984
gene id: 8355:LOC108710984
uniprot id: A0A8J0UTN9
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

8355:LOC108699021
gene id: 8355:LOC108699021
uniprot id: A0A8J1LL65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:zmynd10.L
gene id: 8355:zmynd10.L
uniprot id: A0A1L8GPB4
uniprot id: Q5FWU8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Ciliopathy phenotypes. Although a large percentage of cells fail to generate cilia because of a substantial defect in ciliogenesis, the numbers of centrioles is apparently normal.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Interacts with LRRC6.
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity).
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite
messages: cilium basal body

8355:LOC108696132
gene id: 8355:LOC108696132
uniprot id: A0A1L8FJ80
uniprot id: A0A8J1L4W0
uniprot id: A0A8J1L4Y3
names: Subcellular Location Annotation
messages: Membrane

8355:slc30a4.L
gene id: 8355:slc30a4.L
uniprot id: Q640J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8355:LOC108715541
gene id: 8355:LOC108715541
uniprot id: A0A1L8GFI4
uniprot id: A0A8J1KJ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm

8355:stx5.S
gene id: 8355:stx5.S
uniprot id: A0A1L8GCY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

8355:elavl2.L
gene id: 8355:elavl2.L
uniprot id: A0A8J0TEL3
uniprot id: A0A8J0TGC8
uniprot id: A0A8J0TGJ6
uniprot id: A0A8J0TIA1
uniprot id: A0A8J1KY49
uniprot id: A0A8J1KYV7
uniprot id: A0A8J1KZ51
uniprot id: A0A8J1L046
uniprot id: A0A8J1L0M4
uniprot id: A0A8J1L0R0
uniprot id: A0A8J1L2T6
uniprot id: A0A8J1L2Y9
uniprot id: Q91903
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM elav family.
messages: Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Required for the vegetal localization of vg1 mRNA. Probably required for nervous system development.
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Predominantly expressed in the early stages of oogenesis (stages I to III), with expression levels declining from stage IV onwards. Zygotic expression begins at the early tailbud stage.
messages: Expressed in brain, testis and ovary. Ovarian expression is restricted to follicle cells surrounding the oocyte. From the early tailbud stage, expression is neural-specific and is seen in both the central and peripheral nervous system in differentiating neurons but not proliferating precursors. Expressed in the retina from stage 32 with expression becoming restricted to the ganglion cell layer by later stages.
messages: Part of a ribonucleoprotein (RNP) complex, at least composed of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen. Binds RNA as a homooligomer.
messages: The 45 kDa RNA-binding proteins identified in PubMed:7969126 and PubMed:8873767, and PubMed:11087864 may correspond to elavl2/elrB.
messages: cell cortex

8355:LOC108712992
gene id: 8355:LOC108712992
uniprot id: A0A8J0UQK1
uniprot id: A0A8J0UWX5
uniprot id: A0A8J0UX46
uniprot id: A0A8J0V0N5
uniprot id: A0A8J1MR72
uniprot id: A0A8J1MRB6
uniprot id: A0A8J1MSH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Membrane
messages: Synapse
messages: growth cone

8355:amfr.L
gene id: 8355:amfr.L
uniprot id: Q6PAF9
names: Subcellular Location Annotation
messages: Membrane

8355:tmem132a.L
gene id: 8355:tmem132a.L
uniprot id: A0A310U8Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

8355:LOC121395107
gene id: 8355:LOC121395107
uniprot id: A0A8J1L257
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8355:npm1.S
gene id: 8355:npm1.S
uniprot id: Q7ZTP6
names: Similarity
messages: Belongs to the nucleoplasmin family.

8355:LOC108697251
gene id: 8355:LOC108697251
uniprot id: A0A8J0TE35
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:mkrn2.L
gene id: 8355:mkrn2.L
uniprot id: Q3KQ17
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:slc44a1.S
gene id: 8355:slc44a1.S
uniprot id: A0A1L8HNX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

8355:gipr.L
gene id: 8355:gipr.L
uniprot id: A0A8J0TB26
names: Subcellular Location Annotation
messages: Membrane

8355:atp1a2.S
gene id: 8355:atp1a2.S
uniprot id: Q6PAG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8355:gbx2.2.L
gene id: 8355:gbx2.2.L
uniprot id: Q91907
names: Function
names: Subcellular Location Annotation
messages: May act as a transcription factor for cell pluripotency and differentiation in the embryo.
messages: Nucleus

8355:tet3.L
gene id: 8355:tet3.L
uniprot id: A0A1L8H1L7
uniprot id: A0A8J0UST5
uniprot id: A0A8J0UW62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

8355:slc28a2.L
gene id: 8355:slc28a2.L
uniprot id: A0A1L8GZU6
uniprot id: Q6DDT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

8355:rp2.L
gene id: 8355:rp2.L
uniprot id: A0A1L8HGW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

8355:LOC108700565
gene id: 8355:LOC108700565
uniprot id: A0A1L8F3G7
names: Subcellular Location Annotation
messages: Membrane

8355:slco5a1.S
gene id: 8355:slco5a1.S
uniprot id: A0A1L8FT59
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:b3gat1l.S
gene id: 8355:b3gat1l.S
uniprot id: A0A1L8H5J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:eif4e3.L
gene id: 8355:eif4e3.L
uniprot id: Q6NU27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis.
messages: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity).

8355:LOC121399165
gene id: 8355:LOC121399165
uniprot id: A0A8J1M038
names: Similarity
messages: Belongs to the 3-beta-HSD family.

8355:slc5a11.L
gene id: 8355:slc5a11.L
uniprot id: A0A1L8EYG4
uniprot id: O42135
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8355:htr7l.S
gene id: 8355:htr7l.S
uniprot id: A0A1L8HKF3
uniprot id: Q91559
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

8355:ipo4.L
gene id: 8355:ipo4.L
uniprot id: A0A1L8HYN0
names: Subcellular Location Annotation
messages: Cytoplasm

8355:bco2.L
gene id: 8355:bco2.L
uniprot id: Q6DCS3
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

8355:ahcyl1.S
gene id: 8355:ahcyl1.S
uniprot id: Q66IP1
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

8355:ppip5k1.L
gene id: 8355:ppip5k1.L
uniprot id: A0A1L8H0Q8
uniprot id: A0A8J0USC2
uniprot id: A0A8J0USC7
uniprot id: A0A8J0USG6
uniprot id: A0A8J0USH1
uniprot id: A0A8J0UVP4
uniprot id: A0A8J0UVP9
uniprot id: A0A8J1MLV2
uniprot id: A0A8J1MLZ1
uniprot id: A0A8J1MMU8
uniprot id: A0A8J1MMV3
uniprot id: A0A8J1MNY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

8355:gls.L
gene id: 8355:gls.L
uniprot id: A0A1L8EX64
uniprot id: A0A8J0TWU6
uniprot id: A0A8J0TYA0
names: Similarity
messages: Belongs to the glutaminase family.

8355:LOC108700278
gene id: 8355:LOC108700278
uniprot id: A0A8J0TP70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:gabbr2.S
gene id: 8355:gabbr2.S
uniprot id: A0A8J1L4Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:sypl2.S
gene id: 8355:sypl2.S
uniprot id: A0A8J0U9P8
uniprot id: A0A8J0UHW5
uniprot id: Q7ZWV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

8355:sart1.S
gene id: 8355:sart1.S
uniprot id: Q7ZYC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

8355:LOC108719127
gene id: 8355:LOC108719127
uniprot id: A0A1L8FXX6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8355:LOC108718503
gene id: 8355:LOC108718503
uniprot id: A0A8J1L8P8
uniprot id: A0A8J1LAQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:siva1.S
gene id: 8355:siva1.S
uniprot id: A4FVE4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus

8355:LOC121398273
gene id: 8355:LOC121398273
uniprot id: A0A8J1LUI7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:tmc7.S
gene id: 8355:tmc7.S
uniprot id: A0A1L8EQ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8355:macroh2a2.S
gene id: 8355:macroh2a2.S
uniprot id: Q6GP69
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

8355:LOC108712621
gene id: 8355:LOC108712621
uniprot id: A0A1L8GR53
uniprot id: A0A8J0UNW3
uniprot id: A0A8J0UUI1
uniprot id: A0A8J0UVQ0
uniprot id: A0A8J0UVQ4
uniprot id: A0A8J0UZ46
uniprot id: A0A8J0UZ53
uniprot id: A0A8J1MQ76
uniprot id: A0A8J1MQD3
uniprot id: A0A8J1MR83
uniprot id: A0A8J1MSF2
names: Similarity
messages: Belongs to the RAPGEF2 family.

8355:XB22065625.L
gene id: 8355:XB22065625.L
uniprot id: A0A1L8FUQ0
names: Subcellular Location Annotation
messages: Secreted

8355:cpsf7.L
gene id: 8355:cpsf7.L
uniprot id: A0A1L8GJ34
uniprot id: Q5XHG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

8355:hm13.L
gene id: 8355:hm13.L
uniprot id: A0A8J0TRL8
uniprot id: Q7T0W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

8355:nop2.L
gene id: 8355:nop2.L
uniprot id: A0A1L8FIN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

8355:LOC121400972
gene id: 8355:LOC121400972
uniprot id: A0A8J1MJR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108700586
gene id: 8355:LOC108700586
uniprot id: A0A8J1LN20
names: Similarity
messages: Belongs to the PP1 inhibitor family.

8355:LOC121401657
gene id: 8355:LOC121401657
uniprot id: A0A8J1MPB8
names: Similarity
messages: Belongs to the NXPE family.

8355:LOC108705347
gene id: 8355:LOC108705347
uniprot id: A0A8J0U9H8
names: Similarity
messages: Belongs to the MCM family.

8355:LOC108705683
gene id: 8355:LOC108705683
uniprot id: A0A8J1L6Z1
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:anxa13.L
gene id: 8355:anxa13.L
uniprot id: Q6DFJ4
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

8355:hmx3.S
gene id: 8355:hmx3.S
uniprot id: A0A1L8FEA1
names: Subcellular Location Annotation
messages: Nucleus

8355:tbc1d7.L
gene id: 8355:tbc1d7.L
uniprot id: A0A8J1KVI8
uniprot id: A0A8J1KVJ6
uniprot id: A0A8J1KVJ8
uniprot id: Q6NU66
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

8355:otop1.S
gene id: 8355:otop1.S
uniprot id: A0A1L8HKU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8355:prpf31.S
gene id: 8355:prpf31.S
uniprot id: Q5U5C5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP31 family.
messages: Cajal body
messages: Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex. Component of some MLL1/MLL complex.
messages: Interacts with the snRNP via the Nop domain.
messages: Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.
messages: Nucleus
messages: Nucleus speckle
messages: The coiled coil domain is formed by two non-contiguous helices.

8355:mtfr1.S
gene id: 8355:mtfr1.S
uniprot id: A0A1L8FT41
uniprot id: Q6GNH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

8355:uso1.S
gene id: 8355:uso1.S
uniprot id: A0A1L8HMF8
uniprot id: A0A8J0TQ89
uniprot id: A0A8J1LPE8
uniprot id: A0A8J1LPH3
uniprot id: A0A8J1LQQ9
uniprot id: A0A8J1LRT3
uniprot id: A0A8J1LRT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

8355:cndp2.S
gene id: 8355:cndp2.S
uniprot id: Q7T0R7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

8355:mterf1.L
gene id: 8355:mterf1.L
uniprot id: A0A1L8FVR0
names: Similarity
messages: Belongs to the mTERF family.

8355:pth1r.S
gene id: 8355:pth1r.S
uniprot id: A0A8J0VLM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8355:irx1.L
gene id: 8355:irx1.L
uniprot id: Q9YGK8
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds to the bmp4 promoter to repress gene expression and thus mediate down-regulation of bmp4 by wnt signaling. Controls multiple processes through bmp4-repression including neural plate development, neural crest specification and Spemann organizer development. Involved in the specification of the preplacodal field at the anterior border of the neural plate. Regulates the genetic cascade of interactions that are necessary for positioning the isthmus organizer and the formation of the midbrain-hindbrain boundary. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros. Acts principally as a transcriptional activator during pronephros development.
messages: Although PubMed:17875669 show that irx1 is dispensable for pronephric kidney development, PubMed:18715948 show that irx1 is required for formation of the pronephros.
messages: Belongs to the TALE/IRO homeobox family.
messages: By wnt signaling. Mutually antagonizes bmp4 signaling. Inhibited in the neural plate by foxd5. The anterior limit of expression at the future border between the prethalamus and thalamus is defined by mutual repression with the anterior repressor fezf2, and also by arx. Induced by retinoic acid (RA) during kidney development.
messages: Expressed early in neural differentiation in the neural plate, and expression continues in the neural tube after neural fold closure. Expressed in the presumptive midbrain territory. Also expressed in the prospective neural crest and the preplacodal field, anterior to the neural plate. Strongly expressed in the profundal placode and weakly expressed in the trigeminal placode. Also expressed in the mesoderm in the Spemann organizer from the start of gastrulation, and subsequently in its derivatives; namely in the notochord as well as in the somites of stage 25 embryos, and the somites and notochord of tailbud embryos. Also expressed in specific and overlapping dynamic patterns with irx2 and irx3 during pronephric kidney development. Renal expression begins in the dorsal region of the pronephric anlage at mid neurula stage and continues to at least tailbud stages where expression is confined to the intermediate tubule segment IT1. Renal expression is maintained at tadpole stages.
messages: Nucleus

8355:vamp7.S
gene id: 8355:vamp7.S
uniprot id: A0A1L8F360
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

8355:tmbim1.L
gene id: 8355:tmbim1.L
uniprot id: A0A1L8EVR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8355:ccnb1.L
gene id: 8355:ccnb1.L
uniprot id: A0A1L8I241
names: Similarity
messages: Belongs to the cyclin family.

8355:erfl.S
gene id: 8355:erfl.S
uniprot id: A0A1L8FGT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:LOC108697925
gene id: 8355:LOC108697925
uniprot id: A0A1L8FEG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

8355:LOC108697760
gene id: 8355:LOC108697760
uniprot id: A0A1L8FGU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8355:cox18.L
gene id: 8355:cox18.L
uniprot id: A0A1L8HVD3
uniprot id: A0A8J0ULV8
uniprot id: A0A8J0UN64
uniprot id: Q3B8F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

8355:pef1.L
gene id: 8355:pef1.L
uniprot id: Q5PQ53
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPII-coated vesicle membrane
messages: Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Acts as a negative regulator of ER-Golgi transport (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer; heterodimerizes (via the EF-hand 5) with pdcd6.
messages: Membrane

8355:prkab2.L
gene id: 8355:prkab2.L
uniprot id: Q7SZ97
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

8355:LOC121398240
gene id: 8355:LOC121398240
uniprot id: A0A8J1LWH5
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8355:gsx1.L
gene id: 8355:gsx1.L
uniprot id: A0A1L8HJ13
names: Subcellular Location Annotation
messages: Nucleus

8355:ccnc.L
gene id: 8355:ccnc.L
uniprot id: Q4KLA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
messages: Component of the Mediator complex. The cylin/CDK pair formed by ccnc/cdk8 also associates with the large subunit of RNA polymerase II (By similarity).
messages: Nucleus

8355:htr1f.L
gene id: 8355:htr1f.L
uniprot id: A0A1L8HCU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

8355:mmp1.S
gene id: 8355:mmp1.S
uniprot id: A2VD61
names: Similarity
messages: Belongs to the peptidase M10A family.

8355:dcp2.S
gene id: 8355:dcp2.S
uniprot id: A0A1L8HR25
uniprot id: A0A8J0U2E9
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

8355:LOC108712804
gene id: 8355:LOC108712804
uniprot id: A0A1L8GSC7
uniprot id: A0A8J1MRP9
uniprot id: A0A8J1MSY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

8355:LOC108698953
gene id: 8355:LOC108698953
uniprot id: A0A8J1LK16
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:ppm1f.L
gene id: 8355:ppm1f.L
uniprot id: A0A1L8I0L0
names: Similarity
messages: Belongs to the PP2C family.

8355:cilp2.S
gene id: 8355:cilp2.S
uniprot id: A0A8J1LYH5
names: Subcellular Location Annotation
messages: extracellular matrix

8355:LOC108696880
gene id: 8355:LOC108696880
uniprot id: A0A1L8FPH7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121401273
gene id: 8355:LOC121401273
uniprot id: A0A1L8H2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:grk1.S
gene id: 8355:grk1.S
uniprot id: A0A1L8H8W4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:atp7b.S
gene id: 8355:atp7b.S
uniprot id: A0A1L8HAD8
uniprot id: A0A8J1MFV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

8355:LOC108705587
gene id: 8355:LOC108705587
uniprot id: A0A8J1MWU8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:slc17a9.S
gene id: 8355:slc17a9.S
uniprot id: A0A1L8ELQ1
names: Subcellular Location Annotation
messages: Membrane

8355:ctse.S
gene id: 8355:ctse.S
uniprot id: A0A8J0UGD5
uniprot id: Q805F2
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Expressed predominantly in the anterior and posterior adult stomach and at much lower levels in the larval foregut.
messages: Expression levels are low in surface mucous cells and manicotto gland cells of the foregut epithelium of pro-metamorphic tadpoles. During metamorphosis, expression levels rise markedly in proliferating adult epithelial primordia. In the adult stomach, expression was strongest in oxynticopeptic cells, but was also detected at a lower level in surface mucose cells.
messages: Glycosylated. Contains high mannose-type oligosaccharide (By similarity).
messages: Homodimer; disulfide-linked.
messages: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation (By similarity).

8355:acadl.L
gene id: 8355:acadl.L
uniprot id: Q6DDM7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

8355:birc2.S
gene id: 8355:birc2.S
uniprot id: A0A1L8HAT1
uniprot id: A0A8J1MBV8
uniprot id: A1L2I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

8355:lamtor2.S
gene id: 8355:lamtor2.S
uniprot id: A0A1L8F4K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8355:chst7.L
gene id: 8355:chst7.L
uniprot id: Q32NX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

8355:dusp16.S
gene id: 8355:dusp16.S
uniprot id: A0A1L8GQR9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

8355:LOC108702186
gene id: 8355:LOC108702186
uniprot id: A0A8J0U158
names: Subcellular Location Annotation
messages: Secreted

8355:srsf1.L
gene id: 8355:srsf1.L
uniprot id: A0A8J0UCS9
names: Similarity
messages: Belongs to the splicing factor SR family.

8355:LOC108695376
gene id: 8355:LOC108695376
uniprot id: A0A1L8HY64
uniprot id: A0A8J0T7A2
uniprot id: A0A8J1KQH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

8355:chm.L
gene id: 8355:chm.L
uniprot id: Q6P7I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

8355:g6pc1.3.L
gene id: 8355:g6pc1.3.L
uniprot id: Q6PAG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

8355:fam89a.L
gene id: 8355:fam89a.L
uniprot id: Q08AY9
names: Similarity
messages: Belongs to the FAM89 family.

8355:cyld.S
gene id: 8355:cyld.S
uniprot id: A0A8J1KIA2
uniprot id: A0A8J1KLE1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

8355:slco3a1.L
gene id: 8355:slco3a1.L
uniprot id: A0A1L8H110
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

8355:LOC121402168
gene id: 8355:LOC121402168
uniprot id: A0A8J1MS43
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108710163
gene id: 8355:LOC108710163
uniprot id: A0A8J0UMV7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108718818
gene id: 8355:LOC108718818
uniprot id: A0A1L8I3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

8355:LOC108701934
gene id: 8355:LOC108701934
uniprot id: A0A8J0TY35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108699457
gene id: 8355:LOC108699457
uniprot id: A0A1L8FCY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

8355:LOC108704620
gene id: 8355:LOC108704620
uniprot id: A0A8J1KZL3
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8355:slc26a2.2.L
gene id: 8355:slc26a2.2.L
uniprot id: A0A1L8GXV8
uniprot id: A0A8J1MK78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:wdr18.L
gene id: 8355:wdr18.L
uniprot id: A0A1L8HX76
uniprot id: A0A8J1MIE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). May play a role during development (By similarity).
messages: nucleolus
messages: nucleoplasm

8355:LOC108707676
gene id: 8355:LOC108707676
uniprot id: A0A8J1M7P7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108717635
gene id: 8355:LOC108717635
uniprot id: A0A1L8G0Q2
uniprot id: A0A8J0VE35
uniprot id: A0A8J1KS19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

8355:LOC108713430
gene id: 8355:LOC108713430
uniprot id: A0A1L8HXI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

8355:LOC108706824
gene id: 8355:LOC108706824
uniprot id: A0A1L8HN12
uniprot id: A0A8J0U0T4
names: Subcellular Location Annotation
messages: ruffle membrane

8355:atp6v1g2.L
gene id: 8355:atp6v1g2.L
uniprot id: A0A1L8F8G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8355:tgs1.S
gene id: 8355:tgs1.S
uniprot id: A0A1L8FT27
uniprot id: A0A8J0T6X9
uniprot id: A0A8J0T7U0
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

8355:slf2.L
gene id: 8355:slf2.L
uniprot id: A0A1L8FJB7
names: Similarity
messages: Belongs to the FAM178 family.

8355:cfl1.S
gene id: 8355:cfl1.S
uniprot id: P45593
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the actin-binding proteins ADF family.
messages: Expressed both maternally and zygotically. Maternal expression is gradually replaced with zygotic expression between the morula (stage 5) and tadpole (stage 34) stages.
messages: Expressed diffusely in both animal and vegetal hemispheres of the oocyte. During cleavage, expression accumulates around the cleavage furrow, along the vegetal membrane, and later in the midbody. Strongly expressed in the animal hemisphere during blastula stages, with most cells showing expression by gastrulation. By stage 17, expression is highest in cells of the developing neuroectoderm, and at stage 24 the notochord, neural tube, neural crest, somites and some cells of the archenteron show high expression. By stage 35, expression has declined in the notochord, but remains in the neural tube, epidermis and a layer of cells in the archenteron. Also highly expressed in the retina and neuronal cell bodies at the base of the cement gland but not the cement gland itself. At stage 38, expression is widespread, being highest in the nervous system and retina. In the adult, expression is high in the brain, heart, oocyte, stomach, and low in skeletal muscle.
messages: Inactive when phosphorylated. Phosphorylation levels vary during development. Oocytes contain only the phosphorylated form, and 80-95% of cfl1 protein is phosphorylated in unfertilized eggs. Rapid dephosphorylation occurs within 30 minutes after fertilization. Phosphorylation levels increase again between the morula and blastula stages (5-8 hpf) and then decrease again as gastrulation approaches. Dephosphorylated by pdxp (By similarity).
messages: May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Required for formation of the cleavage furrow during cytokinesis.
messages: Membrane
messages: Nucleus matrix
messages: cell cortex
messages: cytoskeleton

8355:LOC108718832
gene id: 8355:LOC108718832
uniprot id: A0A1L8FZD2
uniprot id: A0A8J1L1N0
names: Subcellular Location Annotation
messages: Membrane

8355:fam161a.L
gene id: 8355:fam161a.L
uniprot id: A0A8J1KLH8
uniprot id: Q66KE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM161 family.
messages: Involved in ciliogenesis.
messages: cilium
messages: cilium basal body

8355:spop.L
gene id: 8355:spop.L
uniprot id: A0A1L8ES82
uniprot id: Q7ZX06
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tdpoz family.
messages: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
messages: Homodimer. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and SPOP, plus a target protein (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The BTB (POZ) domain mediates dimerization and interaction with CUL3.
messages: The MATH domain mediates interaction with protein-ubiquitin ligase substrates.

8355:LOC108699501
gene id: 8355:LOC108699501
uniprot id: A0A1L8F5V7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:adck5.L
gene id: 8355:adck5.L
uniprot id: A0A1L8G0H3
uniprot id: A0A8J0VIB9
uniprot id: A0A8J0VKQ0
uniprot id: A0A8J0VLU2
uniprot id: A0A8J0VPM6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

8355:LOC108716542
gene id: 8355:LOC108716542
uniprot id: A0A1L8G701
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108697157
gene id: 8355:LOC108697157
uniprot id: A0A1L8FDZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108698502
gene id: 8355:LOC108698502
uniprot id: Q66L27
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

8355:LOC108697349
gene id: 8355:LOC108697349
uniprot id: A0A8J1MM87
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:casd1.S
gene id: 8355:casd1.S
uniprot id: A0A8J0VQ83
uniprot id: A0A8J1L1J8
uniprot id: A0A8J1L1J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PC-esterase family. CASD1 subfamily.
messages: Membrane

8355:slc35c1.L
gene id: 8355:slc35c1.L
uniprot id: A0A1L8GIT0
uniprot id: A0A8J0V033
uniprot id: A0A8J1MXM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

8355:lhx1.L
gene id: 8355:lhx1.L
uniprot id: B7ZP59
uniprot id: P29674
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By retinoic acid and by dorsal mesoderm-inducers including activin, derriere, dvr1/vg-1 and nodal.
messages: Exhibits a biphasic expression pattern. Initially localized to the Spemann organizer region of gastrulae, leading to expression in prechordal mesoderm and notochord. In the second phase, expressed in the lateral mesoderm and neural plate, eventually concentrating in the pronephros and the CNS. Expressed in the pronephros primordium by late gastrula (stage 12.5) and becomes restricted to the tips of the tubules and ducts as kidney development progresses. In the CNS, becomes progressively recognizable in anatomically distinct structures during larval development. Within the forebrain, shows almost identical expression to lhx5 in the diencephalon, being expressed in alternating stripes to lhx2 and lhx9. Expressed in the diencephalic pretectum within prosomere 1, hypothalamus, ventral thalamus and zona limitans intrathalamica. In the telencephalon, the expression pattern is distinct from lhx5, being localized in the pallium and subpallium. Also expressed in the ventral territories of midbrain (mesencephalon) and hindbrain (rhombencephalon), being expressed in the mesencephalic tegmentum and hindbrain reticular formation. Also shows intense expression in the cerebellum including Purkinje cells.
messages: Expressed both maternally and zygotically. Expressed at a low level in the unfertilized egg. Expression is highest at the gastrula stage, then declines before rising again during the tadpole stage.
messages: Interacts with ldb1 via the tandem LIM domains. Both LIM domains are required for optimal binding and binding relieves the inhibitory effect of the LIM domains and activates lhx1. Binding to ldb1 also prevents degradation of ldb1 by rnf12. The stoichiometry of lhx1 and ldb1 is important for their function and an excess of ldb1 can inhibit lhx1 function. Interacts with the N-terminal region of rnf12 by a homeobox-dependent mechanism.
messages: Involved in the establishment of the body plan via the Spemann organizer during gastrulation. Transcriptional activator required to induce organizer gene expression downstream of siamois. Promotes head formation by binding to 5'-TAAT'-3' elements in the promoters of head organizer genes cer1 and gsc to stimulate expression. Binds as a complex with siamois and mix-A/mix.1 to the cer1 promoter, and with ldb1 and otx2 to the gsc promoter. Also involved in neural induction via the organizer, including a role in notochord formation. Acts synergistically with ldb1 and ssbp in subsequent axis formation. Involved in kidney development, acting synergistically with pax8 to establish the pronephric primordium in late gastrulae/early neurulae and with pax2 during pronephric morphogenesis in tailbud stages. Has a later role in mediating the activity of inhibitors of ventralization.
messages: Nucleus
messages: The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox.

8355:LOC108704618
gene id: 8355:LOC108704618
uniprot id: A0A8J1KZK3
uniprot id: A0A8J1KZL5
uniprot id: A0A8J1L2F1
names: Similarity
messages: Belongs to the centaurin gamma-like family.

8355:LOC108709356
gene id: 8355:LOC108709356
uniprot id: A0A1L8H624
names: Similarity
messages: Belongs to the NCBP3 family.

8355:sec22a.L
gene id: 8355:sec22a.L
uniprot id: Q6GMF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

8355:LOC108697425
gene id: 8355:LOC108697425
uniprot id: A0A1L8FEK6
uniprot id: A0A8J0TFA2
uniprot id: A0A8J1LE04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

8355:LOC121399398
gene id: 8355:LOC121399398
uniprot id: A0A8J1M2L7
names: Similarity
messages: Belongs to the ANP32 family.

8355:ccnd2.S
gene id: 8355:ccnd2.S
uniprot id: A0A8J1MRK4
uniprot id: Q3KPK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

8355:vps35.S
gene id: 8355:vps35.S
uniprot id: Q5FWV1
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

8355:rpa2.S
gene id: 8355:rpa2.S
uniprot id: A0A8J0UKA6
uniprot id: A0A8J1MAV5
uniprot id: A1L2H9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (By similarity).
messages: Belongs to the replication factor A protein 2 family.
messages: Component of the replication protein A complex (RPA/RP-A), a heterotrimeric complex composed of RPA1, RPA2 and RPA3.
messages: Differentially phosphorylated throughout the cell cycle, becoming phosphorylated at the G1-S transition and dephosphorylated in late mitosis. Phosphorylation increases upon replication fork stalling (By similarity).
messages: Nucleus
messages: PML body

8355:LOC108697976
gene id: 8355:LOC108697976
uniprot id: A0A1L8FGG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:gucy2c.S
gene id: 8355:gucy2c.S
uniprot id: A0A1L8GGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

8355:LOC121396548
gene id: 8355:LOC121396548
uniprot id: A0A1L8FGX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:dnajb14.L
gene id: 8355:dnajb14.L
uniprot id: A0A1L8HV12
names: Subcellular Location Annotation
messages: Membrane

8355:ttyh1.L
gene id: 8355:ttyh1.L
uniprot id: A0A8J0T9J0
uniprot id: Q6AX57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

8355:tmem56.2.S
gene id: 8355:tmem56.2.S
uniprot id: A0A8J0U1W0
names: Subcellular Location Annotation
messages: Membrane

8355:tmod4.L
gene id: 8355:tmod4.L
uniprot id: A0A8J1LG42
uniprot id: A0A8J1LH35
uniprot id: Q66KN0
names: Subcellular Location Annotation
messages: cytoskeleton

8355:LOC108699028
gene id: 8355:LOC108699028
uniprot id: A0A8J0TIZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:kcnmb4.S
gene id: 8355:kcnmb4.S
uniprot id: A0A1L8GUG4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108700425
gene id: 8355:LOC108700425
uniprot id: A0A1L8F556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus

8355:kcne4.S
gene id: 8355:kcne4.S
uniprot id: A0A1L8G4H6
names: Similarity
messages: Belongs to the potassium channel KCNE family.

8355:c9orf116.S
gene id: 8355:c9orf116.S
uniprot id: A0A1L8F128
names: Subcellular Location Annotation
messages: cilium axoneme

8355:tmem41a.S
gene id: 8355:tmem41a.S
uniprot id: A0A1L8EPP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

8355:LOC121396012
gene id: 8355:LOC121396012
uniprot id: A0A8J1LAI8
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108710498
gene id: 8355:LOC108710498
uniprot id: A0A8J0USF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:acvr1.L
gene id: 8355:acvr1.L
uniprot id: Q6DD64
uniprot id: Q91432
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8355:taf10.L
gene id: 8355:taf10.L
uniprot id: Q0IH90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus

8355:LOC108715724
gene id: 8355:LOC108715724
uniprot id: A0A1L8HZZ6
uniprot id: A0A8J0V830
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:LOC121394063
gene id: 8355:LOC121394063
uniprot id: A0A1L8G1U4
names: Similarity
messages: Belongs to the HEBP family.

8355:LOC108717591
gene id: 8355:LOC108717591
uniprot id: A0A1L8G4U1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:fam83h.L
gene id: 8355:fam83h.L
uniprot id: A0A1L8G0L7
names: Similarity
messages: Belongs to the FAM83 family.

8355:ankle2.L
gene id: 8355:ankle2.L
uniprot id: A0A1L8I1A3
uniprot id: A0A8J0V5R8
names: Similarity
messages: Belongs to the ANKLE2 family.

8355:spata18a.S
gene id: 8355:spata18a.S
uniprot id: A0A1L8GRZ0
uniprot id: A0A8J1MRR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

8355:plcb3.L
gene id: 8355:plcb3.L
uniprot id: A0A1L8GJS2
uniprot id: A0A8J1MTE4
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

8355:stip1.L
gene id: 8355:stip1.L
uniprot id: Q7ZWU1
names: Function
names: Subcellular Location Annotation
messages: Acts as a co-chaperone for HSP90AA1 (By similarity). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Nucleus

8355:kcnq5.S
gene id: 8355:kcnq5.S
uniprot id: A0A8J0VFG1
uniprot id: A0A8J1KTG0
uniprot id: A0A8J1KV21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ddx21.S
gene id: 8355:ddx21.S
uniprot id: Q9DF35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
messages: Mitochondrion
messages: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (By similarity). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (By similarity). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (PubMed:12851405) (Probable). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (By similarity). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (By similarity). Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability (By similarity).
messages: Widely expressed. Expressed at higher level in stomach. Expressed at higher level compared to ddx21-b.
messages: cytosol
messages: nucleolus
messages: nucleoplasm

8355:fam13b.S
gene id: 8355:fam13b.S
uniprot id: A0A1L8GVI4
uniprot id: A0A8J1MSE8
names: Similarity
messages: Belongs to the FAM13 family.

8355:rab27b.L
gene id: 8355:rab27b.L
uniprot id: Q6DE89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

8355:MGC115291
gene id: 8355:MGC115291
uniprot id: A0A1L8GUC7
uniprot id: Q52KN5
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

8355:fancm.L
gene id: 8355:fancm.L
uniprot id: A0A8J1LE47
uniprot id: D5MDW0
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

8355:LOC108699077
gene id: 8355:LOC108699077
uniprot id: A0A8J0TMG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:dok6.S
gene id: 8355:dok6.S
uniprot id: A0A8J1L2E2
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

8355:egr1.S
gene id: 8355:egr1.S
uniprot id: Q6NTY6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine.
messages: Cytoplasm
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays a role in regulating the expression of circadian clock genes (By similarity).

8355:fli1b.L
gene id: 8355:fli1b.L
uniprot id: A0A1L8FPG5
uniprot id: A0A8J1L9W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:tmco4.S
gene id: 8355:tmco4.S
uniprot id: A0A1L8FHM5
uniprot id: A0A8J0TH35
names: Similarity
messages: Belongs to the TMCO4 family.

8355:mrpl42.L
gene id: 8355:mrpl42.L
uniprot id: A0A8J0UIE1
uniprot id: A0A8J0UPM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

8355:alas1.L
gene id: 8355:alas1.L
uniprot id: Q6PAZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

8355:ppp1r9b.S
gene id: 8355:ppp1r9b.S
uniprot id: A0A1L8EKZ1
names: Subcellular Location Annotation
messages: cytoskeleton

8355:mif4gd.L
gene id: 8355:mif4gd.L
uniprot id: A3KND5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MIF4GD family.
messages: Cytoplasm
messages: Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity).
messages: Interacts with eif4g1, eif4g2 and slbp; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with eif4g1 which is bound to their 5'-end.
messages: Nucleus

8355:sema3b.L
gene id: 8355:sema3b.L
uniprot id: A0A1L8GPA2
uniprot id: A0A8J1MZM1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ivd.S
gene id: 8355:ivd.S
uniprot id: A0A8J1LP42
uniprot id: A0A8J1LP71
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8355:dock2.L
gene id: 8355:dock2.L
uniprot id: A0A1L8GXG9
uniprot id: A0A8J1MKS8
names: Similarity
messages: Belongs to the DOCK family.

8355:acmsd.S
gene id: 8355:acmsd.S
uniprot id: A0A8J0U1D9
uniprot id: A0A8J1LYG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

8355:srsf1.S
gene id: 8355:srsf1.S
uniprot id: A0A8J1MGK2
names: Similarity
messages: Belongs to the splicing factor SR family.

8355:cxcl10.L
gene id: 8355:cxcl10.L
uniprot id: A0A1L8HVA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8355:rpl8.L
gene id: 8355:rpl8.L
uniprot id: A0A1L8HF43
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

8355:ip6k1.L
gene id: 8355:ip6k1.L
uniprot id: Q6GQ51
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8355:LOC108718670
gene id: 8355:LOC108718670
uniprot id: A0A8J1KWJ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108705521
gene id: 8355:LOC108705521
uniprot id: A0A8J1LEA7
uniprot id: A0A8J1LF83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

8355:LOC121394125
gene id: 8355:LOC121394125
uniprot id: A0A8J1KV09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8355:LOC108711735
gene id: 8355:LOC108711735
uniprot id: A0A1L8H3E7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:blcap.L
gene id: 8355:blcap.L
uniprot id: Q5EAT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLCAP family.
messages: Membrane

8355:grik5.S
gene id: 8355:grik5.S
uniprot id: A0A1L8FGX2
uniprot id: A0A8J1LEQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:tfeb.S
gene id: 8355:tfeb.S
uniprot id: A0A1L8H6Y2
uniprot id: A0A8J1MDJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

8355:nmu.L
gene id: 8355:nmu.L
uniprot id: A0A1L8HTS6
uniprot id: A0A8J1MV42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

8355:best2.S
gene id: 8355:best2.S
uniprot id: Q5XH45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

8355:rgs4.S
gene id: 8355:rgs4.S
uniprot id: A0A1L8GGH1
uniprot id: Q9I9D9
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

8355:ddah1.L
gene id: 8355:ddah1.L
uniprot id: Q7T0R4
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

8355:srsf2.L
gene id: 8355:srsf2.L
uniprot id: Q7ZX57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

8355:osbpl8.S
gene id: 8355:osbpl8.S
uniprot id: A0A1L8GUH1
uniprot id: A0A8J0URE1
uniprot id: A0A8J0UXM5
uniprot id: A0A8J1MU31
names: Similarity
messages: Belongs to the OSBP family.

8355:slc26a4.2.L
gene id: 8355:slc26a4.2.L
uniprot id: A0A1L8GZ57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

8355:gpr179.S
gene id: 8355:gpr179.S
uniprot id: A0A1L8EKP6
uniprot id: A0A8J1M001
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8355:chst6.L
gene id: 8355:chst6.L
uniprot id: Q6GN39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

8355:znf277.L
gene id: 8355:znf277.L
uniprot id: Q52KN1
names: Similarity
messages: Belongs to the ZNF277 family.

8355:polr2i.L
gene id: 8355:polr2i.L
uniprot id: A0A1L8F868
uniprot id: A0A1L8F869
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

8355:XFG 5-1
gene id: 8355:XFG%205-1
uniprot id: P18725
names: Function
messages: Binds to RNA homomers.

8355:lsm7.L
gene id: 8355:lsm7.L
uniprot id: Q6DKD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

8355:pggt1b.L
gene id: 8355:pggt1b.L
uniprot id: A0A1L8I1K8
uniprot id: Q6NTZ4
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

8355:hoxc13.S
gene id: 8355:hoxc13.S
uniprot id: A0A1L8HAD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

8355:orai2.L
gene id: 8355:orai2.L
uniprot id: A0A1L8I147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

8355:LOC108700329
gene id: 8355:LOC108700329
uniprot id: A0A1L8F4H0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:orai2.S
gene id: 8355:orai2.S
uniprot id: Q5EAU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores.
messages: Cell membrane

8355:hsd11b1l.2.S
gene id: 8355:hsd11b1l.2.S
uniprot id: Q6P7J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Secreted

8355:uba3.L
gene id: 8355:uba3.L
uniprot id: A0A1L8GQ11
uniprot id: A0A8J0V863
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

8355:tarbp2.S
gene id: 8355:tarbp2.S
uniprot id: A0A1L8HA44
uniprot id: A0A8J0UKJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC.

8355:slc2a11.2.L
gene id: 8355:slc2a11.2.L
uniprot id: A0A8J0QGE6
uniprot id: A0A8J1MAL8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:apeh.L
gene id: 8355:apeh.L
uniprot id: A0A8J0V389
uniprot id: A0A8J1MXU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

8355:42sp50.L
gene id: 8355:42sp50.L
uniprot id: A4FVE0
uniprot id: P17506
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3 EF-1-alpha are expressed under different developmental control in Xenopus laevis. This protein is expressed exclusively in immature oocytes.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: The 42S RNP particle comprises four subunits each of which contains one molecule of 5S RNA, three molecules of tRNA, two molecules of EF1-alpha and one molecule of the 5S RNA binding protein 43.
messages: This protein is one of two protein components of a 42S RNP particle that is very abundant in previtellogenic oocytes. A major function served by 42sp50 appears to be the storage of tRNAs for later use in oogenesis and early embryogenesis. Purified 42S particles can directly transfer aminoacyl tRNA to ribosomes.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8355:kitlg.S
gene id: 8355:kitlg.S
uniprot id: Q8AYN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

8355:bcap29.S
gene id: 8355:bcap29.S
uniprot id: A0A1L8GU26
uniprot id: Q6INE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

8355:uqcc2.S
gene id: 8355:uqcc2.S
uniprot id: Q6GQ35
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

8355:fbln5.S
gene id: 8355:fbln5.S
uniprot id: A0A8J0TQE3
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:aldh1a2.S
gene id: 8355:aldh1a2.S
uniprot id: A0A1L8GT05
uniprot id: A0A8J0UWV1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8355:LOC108719472
gene id: 8355:LOC108719472
uniprot id: A0A8J1L302
names: Similarity
messages: Belongs to the RBR family.

8355:LOC108699174
gene id: 8355:LOC108699174
uniprot id: A0A1L8FAG5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8355:ube2g2.L
gene id: 8355:ube2g2.L
uniprot id: Q6DFI4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:slc25a1-b
gene id: 8355:slc25a1-b
uniprot id: A0A8J0Q7F3
uniprot id: A5D8Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8355:LOC121402248
gene id: 8355:LOC121402248
uniprot id: A0A8J1MSM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:rbpms2.L
gene id: 8355:rbpms2.L
uniprot id: A0A8J1MHB1
uniprot id: Q66IX3
names: Subcellular Location Annotation
messages: Cytoplasm

8355:mrps11.S
gene id: 8355:mrps11.S
uniprot id: A0A8J0UV37
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

8355:LOC121396906
gene id: 8355:LOC121396906
uniprot id: A0A8J1LG21
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:coro6.S
gene id: 8355:coro6.S
uniprot id: A0A1L8H4U5
uniprot id: A0A8J0UJ26
names: Similarity
messages: Belongs to the WD repeat coronin family.

8355:LOC108714105
gene id: 8355:LOC108714105
uniprot id: A0A1L8GL35
uniprot id: A0A8J1MWA7
uniprot id: A0A8J1MWI3
uniprot id: A0A8J1MXF5
uniprot id: A0A8J1MYR8
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8355:tat.L
gene id: 8355:tat.L
uniprot id: A0A1L8GKR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

8355:rnf182.S
gene id: 8355:rnf182.S
uniprot id: Q6INB3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates the ubiquitination of atp6v0c and targets it to degradation via the ubiquitin-proteasome pathway.
messages: Interacts with ATP6V0C.
messages: Membrane
messages: The RING-type zinc finger domain is required for E3 ligase activity.

8355:f11r.L
gene id: 8355:f11r.L
uniprot id: Q2VPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:edn1.S
gene id: 8355:edn1.S
uniprot id: A0PG99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

8355:LOC121400456
gene id: 8355:LOC121400456
uniprot id: A0A8J1MDT7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108716607
gene id: 8355:LOC108716607
uniprot id: A0A1L8G6Z4
names: Similarity
messages: Belongs to the acyl-CoA oxidase family.

8355:ankrd34a.S
gene id: 8355:ankrd34a.S
uniprot id: A0A1L8F4H1
names: Similarity
messages: Belongs to the ANKRD34 family.

8355:chsy1.S
gene id: 8355:chsy1.S
uniprot id: A0A1L8GSE6
uniprot id: A0A8J0UZX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

8355:akirin2.S
gene id: 8355:akirin2.S
uniprot id: Q6GQB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the akirin family.
messages: Homodimer (By similarity). Interacts with actl6a/baf53a (PubMed:28193841). Interacts with gmnn (PubMed:28193841).
messages: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:28193841). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: acts by bridging fully assembled 20S proteasomes with nuclear import receptor ipo9 (By similarity). Involved in both neural precursor maintenance and terminal neural differentiation: bridges gmnn and actl6a/baf53a in neural progenitor cells, antagonizing the activity of gmnn, thereby suppressing sox2 expression (PubMed:28193841). Also required for proper activation of neurod1 and neuronal differentiation (PubMed:28193841). Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity).
messages: Nucleus

8355:apex1.S
gene id: 8355:apex1.S
uniprot id: A0A8J0UCG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

8355:nxn.S
gene id: 8355:nxn.S
uniprot id: Q6GM16
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoredoxin family.
messages: Depletion causes significant defects in head formation with absence of eye structures.
messages: Functions as a redox-dependent negative regulator of the Wnt signaling pathway.
messages: Nucleus
messages: cytosol

8355:LOC108698286
gene id: 8355:LOC108698286
uniprot id: A0A8J0TI39
names: Subcellular Location Annotation
messages: Membrane

8355:adprh
gene id: 8355:adprh
uniprot id: A0A8J0Q1R5
uniprot id: Q5XH10
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

8355:c7orf25.L
gene id: 8355:c7orf25.L
uniprot id: Q08AW5
names: Similarity
messages: Belongs to the UPF0415 family.

8355:LOC121397310
gene id: 8355:LOC121397310
uniprot id: A0A1L8FAM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:gigyf2.S
gene id: 8355:gigyf2.S
uniprot id: Q5U236
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GIGYF family.
messages: Component of the 4EHP-GYF2 complex (By similarity).
messages: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation.

8355:shoc2.S
gene id: 8355:shoc2.S
uniprot id: Q8AVI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHOC2 family.
messages: Cytoplasm
messages: Nucleus
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of raf1 kinase and stimulate raf1 activity at specialized signaling complexes (By similarity).

8355:LOC108705377
gene id: 8355:LOC108705377
uniprot id: A0A310TP13
uniprot id: A0A8J0U6T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:XB17329841.S
gene id: 8355:XB17329841.S
uniprot id: Q4KL84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8355:hspa4.L
gene id: 8355:hspa4.L
uniprot id: A0A1L8GXI4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

8355:lig4.L
gene id: 8355:lig4.L
uniprot id: Q6GLS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

8355:LOC108719473
gene id: 8355:LOC108719473
uniprot id: A0A1L8G0E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:crbn.L
gene id: 8355:crbn.L
uniprot id: A0A1L8GPG0
uniprot id: A0A8J0UYF4
uniprot id: A0A8J1N0F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

8355:LOC108717456
gene id: 8355:LOC108717456
uniprot id: A0A8J1KUU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:uts2b.L
gene id: 8355:uts2b.L
uniprot id: J7MG68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

8355:LOC108695933
gene id: 8355:LOC108695933
uniprot id: A0A8J0T930
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:tjp3.L
gene id: 8355:tjp3.L
uniprot id: A0A1L8HW84
uniprot id: A0A8J0UK49
uniprot id: A0A8J0ULG5
uniprot id: Q4V7W7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:LOC108700685
gene id: 8355:LOC108700685
uniprot id: A0A8J1LLH4
uniprot id: A0A8J1LMC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ddrgk1.L
gene id: 8355:ddrgk1.L
uniprot id: A0A8J0T586
uniprot id: A0A8J0TEP1
names: Similarity
messages: Belongs to the DDRGK1 family.

8355:tpk1.L
gene id: 8355:tpk1.L
uniprot id: A0A1L8FWN4
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

8355:pgp.S
gene id: 8355:pgp.S
uniprot id: A0A8J0TZR3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

8355:LOC108706732
gene id: 8355:LOC108706732
uniprot id: A0A8J1M1P0
uniprot id: A0A8J1M3J0
names: Subcellular Location Annotation
messages: Cytoplasm

8355:olah.L
gene id: 8355:olah.L
uniprot id: A0A1L8FVM9
names: Similarity
messages: Belongs to the thioesterase family.

8355:galt.S
gene id: 8355:galt.S
uniprot id: A0A310UCX3
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

8355:rtcb.S
gene id: 8355:rtcb.S
uniprot id: A0A1L8GQR4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

8355:peli1.S
gene id: 8355:peli1.S
uniprot id: A0A1L8G0M0
uniprot id: A0A8J1KS38
names: Similarity
messages: Belongs to the pellino family.

8355:cdc7.L
gene id: 8355:cdc7.L
uniprot id: Q9PWM7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC121401349
gene id: 8355:LOC121401349
uniprot id: A0A8J1MK23
names: Subcellular Location Annotation
messages: Membrane

8355:tsc22d1.L
gene id: 8355:tsc22d1.L
uniprot id: A0A1L8HHL1
uniprot id: A0A8J0UB55
uniprot id: A0A8J1M5L6
uniprot id: Q63ZU5
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

8355:prdm5.L
gene id: 8355:prdm5.L
uniprot id: A0A8J0UN98
uniprot id: A0A8J0USK3
names: Subcellular Location Annotation
messages: Nucleus

8355:clic3.S
gene id: 8355:clic3.S
uniprot id: A0A1L8F0V1
uniprot id: A0A8J0TNN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

8355:il17d.S
gene id: 8355:il17d.S
uniprot id: A0A1L8HAP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8355:LOC108708438
gene id: 8355:LOC108708438
uniprot id: A0A1L8HGZ5
uniprot id: A0A8J0UG34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

8355:LOC108710075
gene id: 8355:LOC108710075
uniprot id: A0A8J0ULA8
names: Subcellular Location Annotation
messages: Membrane

8355:ncapg2.L
gene id: 8355:ncapg2.L
uniprot id: Q2TAW0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex, which contains the smc2 and smc4 heterodimer, and three non SMC subunits that probably regulate the complex: ncaph2, ncapd3 and ncapg2.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

8355:setd1b.L
gene id: 8355:setd1b.L
uniprot id: A0A1L8I106
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus speckle

8355:cd99l2.S
gene id: 8355:cd99l2.S
uniprot id: A0A1L8F2Y0
uniprot id: A0A8J0TGX1
uniprot id: A0A8J1LNH8
names: Similarity
messages: Belongs to the CD99 family.

8355:LOC108704303
gene id: 8355:LOC108704303
uniprot id: A0A8J0U496
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108701346
gene id: 8355:LOC108701346
uniprot id: A0A1L8EW44
uniprot id: A0A8J0TW51
uniprot id: A0A8J1LRG6
uniprot id: A0A8J1LSS6
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121399163
gene id: 8355:LOC121399163
uniprot id: A0A8J1LZZ8
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:szl.S
gene id: 8355:szl.S
uniprot id: A0A8J1MPX0
uniprot id: O73821
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:atp5mc1.L
gene id: 8355:atp5mc1.L
uniprot id: A0A1L8HIH0
uniprot id: A0A8J0UB69
uniprot id: Q5XGW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

8355:senp6.S
gene id: 8355:senp6.S
uniprot id: A0A8J0VEG0
uniprot id: A0A8J1KT50
uniprot id: A0A8J1KUN0
uniprot id: B7TYL1
names: Similarity
messages: Belongs to the peptidase C48 family.

8355:ctsz.L
gene id: 8355:ctsz.L
uniprot id: Q6INK5
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:gtf3a.L
gene id: 8355:gtf3a.L
uniprot id: P03001
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Involved in ribosomal large subunit biogenesis (By similarity). Acts as both a positive transcription factor for 5S RNA genes and a specific RNA binding protein that complexes with 5S RNA in oocytes to form the 7S ribonucleoprotein storage particle. May play an essential role in the developmental change in 5S RNA gene expression. Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III (PubMed:2253880, PubMed:1538401, PubMed:1762917). Also binds the transcribed 5S RNA's (By similarity).
messages: Nucleus
messages: Synthesized in oocytes and, in much lower levels, in somatic cells.
messages: The N-terminus is blocked.
messages: The levels follow the transcriptional activity of oocyte type 5S RNA genes during embryogenesis, present in very high levels in maturing oocytes when oocyte type 5S genes are being expressed, and in much lower levels in somatic cells where the oocyte type genes are not expressed.

8355:LOC108712323
gene id: 8355:LOC108712323
uniprot id: A0A8J1MR08
uniprot id: A0A8J1MSA7
names: Subcellular Location Annotation
messages: Cytoplasm

8355:hacd1.S
gene id: 8355:hacd1.S
uniprot id: A0A8J0VJH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:sgip1.S
gene id: 8355:sgip1.S
uniprot id: A0A8J0V789
uniprot id: A0A8J1KIX0
uniprot id: A0A8J1KIX5
uniprot id: A0A8J1KIY7
uniprot id: A0A8J1KIZ4
uniprot id: A0A8J1KKN1
uniprot id: A0A8J1KKN5
uniprot id: A0A8J1KM32
uniprot id: A0A8J1KM38
names: Function
names: Subcellular Location Annotation
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: clathrin-coated pit

8355:lyve1.L
gene id: 8355:lyve1.L
uniprot id: A0A1L8GIJ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:prdm1.S
gene id: 8355:prdm1.S
uniprot id: A0A1L8G300
uniprot id: Q9PUI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

8355:LOC121403053
gene id: 8355:LOC121403053
uniprot id: A0A1L8GM90
uniprot id: A0A8J1MWY6
uniprot id: A0A8J1MX78
uniprot id: A0A8J1MYN8
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:mb21d1.L
gene id: 8355:mb21d1.L
uniprot id: A0A8J0TW72
uniprot id: A0A8J0U3Y2
uniprot id: A0A8J1KQP3
names: Similarity
messages: Belongs to the mab-21 family.

8355:eif2s1.L
gene id: 8355:eif2s1.L
uniprot id: A0A1L8FB83
uniprot id: A0A8J1LKY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

8355:pgam2.L
gene id: 8355:pgam2.L
uniprot id: Q7SYX4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

8355:LOC108705859
gene id: 8355:LOC108705859
uniprot id: A0A8J0TZB9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:gfi1b.L
gene id: 8355:gfi1b.L
uniprot id: Q6DCW1
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation (By similarity).
messages: Nucleus
messages: The zinc finger domain is essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.

8355:LOC108696966
gene id: 8355:LOC108696966
uniprot id: A0A1L8FIW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:trhr.L
gene id: 8355:trhr.L
uniprot id: A0A1L8FZU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

8355:phpt1.L
gene id: 8355:phpt1.L
uniprot id: Q3B8E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the janus family.
messages: Cytoplasm
messages: Exhibits phosphohistidine phosphatase activity.
messages: Monomer.

8355:pgap1.L
gene id: 8355:pgap1.L
uniprot id: Q66J01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity).

8355:LOC108698614
gene id: 8355:LOC108698614
uniprot id: A0A8J0TL22
uniprot id: A0A8J1LH61
names: Similarity
messages: Belongs to the spectrin family.

8355:capn8.1.L
gene id: 8355:capn8.1.L
uniprot id: A0A8J0V4Q1
uniprot id: A0A8J0VDF1
uniprot id: Q9I8T0
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:LOC121395748
gene id: 8355:LOC121395748
uniprot id: A0A1L8FIJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:rnpepl1.L
gene id: 8355:rnpepl1.L
uniprot id: A0A8J1KPA3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8355:crygbl.5.S
gene id: 8355:crygbl.5.S
uniprot id: A0A8J0U519
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:mknk2.S
gene id: 8355:mknk2.S
uniprot id: A0JPI2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:sult2a1.S
gene id: 8355:sult2a1.S
uniprot id: A0A8J1LDD2
uniprot id: A0A8J1LEX3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:LOC108699281
gene id: 8355:LOC108699281
uniprot id: A0A1L8FB54
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

8355:LOC108696514
gene id: 8355:LOC108696514
uniprot id: A0A8J0T2F1
uniprot id: A0A8J1L6T8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:kmt5b.L
gene id: 8355:kmt5b.L
uniprot id: A0A1L8GJW5
uniprot id: A0A8J0UTL8
uniprot id: A0A8J0UZE6
uniprot id: Q5RJX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity).
messages: Nucleus

8355:kcnt2.S
gene id: 8355:kcnt2.S
uniprot id: A0A1L8GGM1
uniprot id: A0A8J1KLA1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cc2d1b.S
gene id: 8355:cc2d1b.S
uniprot id: A0A1L8GG15
uniprot id: A0A8J0V6Z9
uniprot id: A0A8J0V7K3
names: Similarity
messages: Belongs to the CC2D1 family.

8355:LOC121395513
gene id: 8355:LOC121395513
uniprot id: A0A1L8FNZ0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:pdpk1.L
gene id: 8355:pdpk1.L
uniprot id: A0A8J0PX21
uniprot id: A0A8J0TT69
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

8355:fgf16.S
gene id: 8355:fgf16.S
uniprot id: A0A1L8F2F1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:LOC108710248
gene id: 8355:LOC108710248
uniprot id: A0A1L8GY86
uniprot id: A0A8J1ML64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.

8355:LOC108719672
gene id: 8355:LOC108719672
uniprot id: A0A8J0VME4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

8355:hs3st1.S
gene id: 8355:hs3st1.S
uniprot id: Q6P417
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:LOC100036918
gene id: 8355:LOC100036918
uniprot id: A1L2Q3
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

8355:zbed6cl.S
gene id: 8355:zbed6cl.S
uniprot id: A0A8J0T7N1
names: Subcellular Location Annotation
messages: Nucleus

8355:dck.1.L
gene id: 8355:dck.1.L
uniprot id: A0A1L8HV70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DCK/DGK family.
messages: Homodimer.
messages: Nucleus
messages: Phosphorylates the deoxyribonucleosides deoxyadenosine, deoxycytidine and deoxyguanosine with highest activity against deoxycytidine followed by deadenosine and deoxyguanosine (PubMed:27906638). Shows only very minor activity against deoxyuridine and deoxythymidine (PubMed:27906638).

8355:mrps12.L
gene id: 8355:mrps12.L
uniprot id: Q7SZ18
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

8355:cmbl.L
gene id: 8355:cmbl.L
uniprot id: Q5XH09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: Cysteine hydrolase.
messages: cytosol

8355:apoa1.S
gene id: 8355:apoa1.S
uniprot id: Q7SZA1
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

8355:LOC108704415
gene id: 8355:LOC108704415
uniprot id: A0A8J1KKH6
uniprot id: A0A8J1KNK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

8355:LOC108702652
gene id: 8355:LOC108702652
uniprot id: A0A8J1LZV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

8355:dhrsx.L
gene id: 8355:dhrsx.L
uniprot id: A0A8J1M6M6
uniprot id: A0A8J1M7E3
uniprot id: Q66KN7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:cenpm.L
gene id: 8355:cenpm.L
uniprot id: Q3KQ10
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere

8355:pygm.L
gene id: 8355:pygm.L
uniprot id: Q801T6
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

8355:LOC121399771
gene id: 8355:LOC121399771
uniprot id: A0A8J1M8A4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108708523
gene id: 8355:LOC108708523
uniprot id: Q7ZYF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Involved in calcium binding and microtubule stabilization.

8355:LOC121399539
gene id: 8355:LOC121399539
uniprot id: A0A1L8HRU1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:shisa3.S
gene id: 8355:shisa3.S
uniprot id: Q7T0Z7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Shisa' was named after a sculpture form, common to southern Japan, with a large head similar to the Egyptian sphinx.
messages: Belongs to the shisa family.
messages: Endoplasmic reticulum membrane
messages: Interacts with fzd8 and fgfr1.
messages: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both fgf and wnt signaling. Regulates head and somite developmen. Inhibits both wnt and fgf signaling through the regulation of protein maturation and cell surface transportation of their receptors within the endoplasmic reticulum.

8355:oxtr.L
gene id: 8355:oxtr.L
uniprot id: A0A1L8GPH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:fgd6.S
gene id: 8355:fgd6.S
uniprot id: A0A1L8GUJ3
names: Subcellular Location Annotation
messages: cytoskeleton

8355:LOC108710319
gene id: 8355:LOC108710319
uniprot id: A0A8J0US80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

8355:kcnf1.S
gene id: 8355:kcnf1.S
uniprot id: A0A1L8G5I5
names: Subcellular Location Annotation
messages: Membrane

8355:tmem184c.L
gene id: 8355:tmem184c.L
uniprot id: Q6GQE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM184 family.
messages: May play a role in cell growth.
messages: Membrane

8355:LOC108698850
gene id: 8355:LOC108698850
uniprot id: A0A8J1LJG5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:miga1.L
gene id: 8355:miga1.L
uniprot id: A0A1L8GLN5
names: Similarity
messages: Belongs to the mitoguardin family.

8355:LOC108712727
gene id: 8355:LOC108712727
uniprot id: A0A1L8HWX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

8355:ap3m2.L
gene id: 8355:ap3m2.L
uniprot id: A0A1L8H259
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

8355:LOC108715934
gene id: 8355:LOC108715934
uniprot id: A0A1L8GI35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

8355:jund.2.S
gene id: 8355:jund.2.S
uniprot id: A0A8J0U5J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

8355:phr.L
gene id: 8355:phr.L
uniprot id: A0A8J0U5A8
uniprot id: Q3C2L7
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

8355:LOC108699927
gene id: 8355:LOC108699927
uniprot id: A0A8J0TNT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:apoc2.L
gene id: 8355:apoc2.L
uniprot id: A0A1L8FNA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
messages: Secreted

8355:foxp3.L
gene id: 8355:foxp3.L
uniprot id: A0A8J1LE30
uniprot id: B1B546
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC100037226
gene id: 8355:LOC100037226
uniprot id: A0A8J0TDD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

8355:prkci.S
gene id: 8355:prkci.S
uniprot id: A0A310U4I1
uniprot id: A0A8J0U635
uniprot id: A0A8J0U7C1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

8355:xcr1.L
gene id: 8355:xcr1.L
uniprot id: A0A1L8FWR9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:zdhhc7.S
gene id: 8355:zdhhc7.S
uniprot id: A0A1L8GF39
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:cyp46a1.1.L
gene id: 8355:cyp46a1.1.L
uniprot id: A0A8J0U699
uniprot id: A0A8J1LHC5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:pip4p2.L
gene id: 8355:pip4p2.L
uniprot id: Q5EAU3
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Late endosome membrane
messages: Lysosome membrane

8355:trnt1.S
gene id: 8355:trnt1.S
uniprot id: Q8AXB8
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

8355:baat.S
gene id: 8355:baat.S
uniprot id: A0A1L8HRY1
uniprot id: A0A8J1M4D4
uniprot id: A0A8J1M5H1
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8355:rap2a.S
gene id: 8355:rap2a.S
uniprot id: Q7ZX67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

8355:srd5a2.S
gene id: 8355:srd5a2.S
uniprot id: A0A1L8G2C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane
messages: Microsome membrane

8355:pdss1.L
gene id: 8355:pdss1.L
uniprot id: A0A1L8FVH2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

8355:gnat1.L
gene id: 8355:gnat1.L
uniprot id: P38407
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.

8355:nol11.S
gene id: 8355:nol11.S
uniprot id: A0A8J0TYZ1
uniprot id: Q2VPH7
names: Subcellular Location Annotation
messages: nucleolus

8355:LOC108704356
gene id: 8355:LOC108704356
uniprot id: A0A8J0U3S7
names: Similarity
messages: Belongs to the TMEM178 family.

8355:spry1.L
gene id: 8355:spry1.L
uniprot id: A0A1L8HUP5
uniprot id: A0A8J0UET1
uniprot id: B5MGQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

8355:cdkn1a.S
gene id: 8355:cdkn1a.S
uniprot id: A0A1L8H6B5
names: Similarity
messages: Belongs to the CDI family.

8355:psma6.S
gene id: 8355:psma6.S
uniprot id: Q5XGL4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

8355:trhde.S
gene id: 8355:trhde.S
uniprot id: A0A1L8GUE7
names: Similarity
messages: Belongs to the peptidase M1 family.

8355:sult5a1.L
gene id: 8355:sult5a1.L
uniprot id: Q0IHC7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:tlcd5.L
gene id: 8355:tlcd5.L
uniprot id: A0A1L8FLG7
names: Subcellular Location Annotation
messages: Membrane

8355:rbl2.L
gene id: 8355:rbl2.L
uniprot id: A0A1L8GKN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

8355:prom2.L
gene id: 8355:prom2.L
uniprot id: A0A8J1MGC0
uniprot id: D0PWG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

8355:elavl4.L
gene id: 8355:elavl4.L
uniprot id: A0A1L8GMI8
uniprot id: A0A8J1MTD9
uniprot id: A0A8J1MUG9
uniprot id: A0A8J1MUT4
uniprot id: A0A8J1MVQ5
uniprot id: Q7SZT7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Expressed after stage 19 (late neurula).
messages: Expression is neural-specific. In the retina, expressed in the ganglion cell layer from stage 28 onwards and in amacrine cells from stage 35 onwards. Expressed in the tailbud and adult brain; in tailbuds, expression is predominant in the cortical plate.
messages: Perikaryon
messages: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (By similarity). Plays a role in the regulation of mRNA stability, alternative splicing and translation (By similarity). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Mainly play a role in neuron-specific RNA processing (By similarity).
messages: axon
messages: dendrite
messages: growth cone

8355:hoxa1.S
gene id: 8355:hoxa1.S
uniprot id: A0A1L8FRB8
names: Subcellular Location Annotation
messages: Nucleus

8355:actr10.L
gene id: 8355:actr10.L
uniprot id: Q52KY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

8355:dcun1d3.L
gene id: 8355:dcun1d3.L
uniprot id: Q6DFA1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes. At the cell membrane, can promote and as well inhibit cullins neddylation.
messages: Cytoplasm
messages: May interact (via the DCUN1 domain) with unneddylated cullins.
messages: Nucleus
messages: The DCUN1 domain, also known as PONY domain, mediates the interaction with different cullins.
messages: perinuclear region

8355:ebna1bp2.L
gene id: 8355:ebna1bp2.L
uniprot id: A0A1L8GM20
uniprot id: Q9I8J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

8355:lamtor5.S
gene id: 8355:lamtor5.S
uniprot id: Q6IRS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LAMTOR5 family.
messages: Cytoplasm
messages: Lysosome
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity).

8355:LOC108695796
gene id: 8355:LOC108695796
uniprot id: A0A8J1L8F1
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

8355:LOC108705399
gene id: 8355:LOC108705399
uniprot id: A0A310U820
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:LOC108701836
gene id: 8355:LOC108701836
uniprot id: A0A8J1LU28
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:duox2.L
gene id: 8355:duox2.L
uniprot id: A0A1L8H098
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

8355:LOC108711149
gene id: 8355:LOC108711149
uniprot id: A0A8J0UR89
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

8355:nppb.S
gene id: 8355:nppb.S
uniprot id: A0A1L8FFP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

8355:XB5812047.L
gene id: 8355:XB5812047.L
uniprot id: A0A1L8H1R2
names: Similarity
messages: Belongs to the peptidase C14A family.

8355:LOC108707092
gene id: 8355:LOC108707092
uniprot id: A0A1L8HQ35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.
messages: Monomer.

8355:amigo1.S
gene id: 8355:amigo1.S
uniprot id: A0A1L8H6X1
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

8355:LOC108715803
gene id: 8355:LOC108715803
uniprot id: A0A1L8I029
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.
messages: Monomer.

8355:bace2.L
gene id: 8355:bace2.L
uniprot id: Q7T0Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane

8355:LOC108714211
gene id: 8355:LOC108714211
uniprot id: A0A8J0V5X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

8355:LOC108710333
gene id: 8355:LOC108710333
uniprot id: A0A1L8H267
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:nagpa.L
gene id: 8355:nagpa.L
uniprot id: A0A1L8HDP6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:twf2.L
gene id: 8355:twf2.L
uniprot id: Q7ZXP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity).
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Interacts with G-actin; ADP-actin form and capping protein (CP).
messages: cytoskeleton
messages: perinuclear region

8355:timm21.L
gene id: 8355:timm21.L
uniprot id: A0A8J1KVY6
uniprot id: Q5XKA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

8355:LOC108696207
gene id: 8355:LOC108696207
uniprot id: A0A8J1L568
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

8355:kif15.L
gene id: 8355:kif15.L
uniprot id: Q91785
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.
messages: Cytoplasm
messages: Expressed maternally in oocytes and eggs (at protein level).
messages: Homodimer. Dimerization is required for targeting to microtubule minus ends. Found in a complex with tpx2 and microtubules. Its association with microtubules and targeting to microtubule minus ends requires tpx2.
messages: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. Required for centrosome separation and maintenance of spindle bipolarity during mitosis.
messages: Strongly expressed in testis and weakly in lung (at protein level).
messages: centrosome
messages: spindle
messages: spindle pole

8355:LOC108696562
gene id: 8355:LOC108696562
uniprot id: A0A8J0TBJ9
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

8355:malsu1.L
gene id: 8355:malsu1.L
uniprot id: A0A1L8FVZ3
names: Similarity
messages: Belongs to the Iojap/RsfS family.

8355:idi1.L
gene id: 8355:idi1.L
uniprot id: A0A8J0VF13
uniprot id: Q640H7
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

8355:LOC108710539
gene id: 8355:LOC108710539
uniprot id: A0A1L8H4J7
names: Subcellular Location Annotation
messages: Membrane

8355:necap2.L
gene id: 8355:necap2.L
uniprot id: Q6AX72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

8355:LOC108698154
gene id: 8355:LOC108698154
uniprot id: A0A8J0T9R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

8355:pparg.S
gene id: 8355:pparg.S
uniprot id: A0A8J1KKI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

8355:calb1.S
gene id: 8355:calb1.S
uniprot id: Q66IN8
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

8355:LOC108712887
gene id: 8355:LOC108712887
uniprot id: A0A1L8GST8
uniprot id: A0A8J1MT73
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108719073
gene id: 8355:LOC108719073
uniprot id: A0A8J0VNY2
uniprot id: A0A8J1KXY3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:jagn1.S
gene id: 8355:jagn1.S
uniprot id: A0A1L8GHV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:bdkrb2.L
gene id: 8355:bdkrb2.L
uniprot id: A0A1L8F9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

8355:LOC108705707
gene id: 8355:LOC108705707
uniprot id: A0A8J1MJR5
names: Subcellular Location Annotation
messages: Membrane

8355:slc26a2.L
gene id: 8355:slc26a2.L
uniprot id: A0A8J0UTJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

8355:LOC108709102
gene id: 8355:LOC108709102
uniprot id: A0A8J1MDI8
uniprot id: A0A8J1MDJ5
uniprot id: A0A8J1MDZ3
uniprot id: A0A8J1MFD7
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

8355:LOC121401192
gene id: 8355:LOC121401192
uniprot id: A0A8J1MI99
names: Subcellular Location Annotation
messages: Membrane

8355:ttc29.L
gene id: 8355:ttc29.L
uniprot id: Q32NR4
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Axonemal protein which is implicated in axonemal and/or peri-axonemal structures assembly and regulates flagella assembly and beating and therefore sperm motility.
messages: The TPR repeats are required for proper localization into the axoneme and proper function in flagella beating and motility.
messages: flagellum axoneme

8355:LOC108695657
gene id: 8355:LOC108695657
uniprot id: A0A8J0SZE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:mogat2.1.L
gene id: 8355:mogat2.1.L
uniprot id: Q5M7F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA.
messages: Endoplasmic reticulum membrane
messages: perinuclear region

8355:LOC121399054
gene id: 8355:LOC121399054
uniprot id: A0A8J1LZ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

8355:lhfpl1.L
gene id: 8355:lhfpl1.L
uniprot id: A0A1L8F7F6
names: Subcellular Location Annotation
messages: Membrane

8355:tex10.S
gene id: 8355:tex10.S
uniprot id: A0A1L8FRY8
uniprot id: A0A8J1L3I4
uniprot id: Q5XGX9
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

8355:lrrcc1.L
gene id: 8355:lrrcc1.L
uniprot id: Q6NRC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRCC1 family.
messages: Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis (By similarity).
messages: centriole

8355:bnip3l.S
gene id: 8355:bnip3l.S
uniprot id: A0A8J1MQL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

8355:srp9.L
gene id: 8355:srp9.L
uniprot id: A0A8J1KPJ1
uniprot id: Q6AZS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

8355:esrrgr.L
gene id: 8355:esrrgr.L
uniprot id: A0A1L8F8W2
uniprot id: A0A8J0TK48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8355:adamts16.L
gene id: 8355:adamts16.L
uniprot id: A0A1L8FX68
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:fbp1.S
gene id: 8355:fbp1.S
uniprot id: A0A1L8HPB0
names: Similarity
messages: Belongs to the FBPase class 1 family.

8355:actg1.L
gene id: 8355:actg1.L
uniprot id: Q32NP0
names: Similarity
messages: Belongs to the actin family.

8355:LOC108717837
gene id: 8355:LOC108717837
uniprot id: A0A1L8G221
uniprot id: A0A8J1KVU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8355:fxr1.L
gene id: 8355:fxr1.L
uniprot id: A3KMH8
uniprot id: P51115
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FMR1 family.
messages: Cytoplasm
messages: During embryogenesis, isoform 2 is present from fertilization (stage 0) whereas isoform 1 is first present after stage 30. In the tadpole (stage 36), isoform 1 shows high expression in somites forming the caudal muscle and low expression in the eye. In adults, isoform 1 is expressed in heart and muscle, whereas isoform 2 is expressed in the brain, liver and kidney.
messages: Nucleus
messages: RNA-binding protein. Binds poly(G) and poly(U) but not poly(A) or poly(C). Regulates somite formation, probably by regulating gene expression.

8355:mtfr1.L
gene id: 8355:mtfr1.L
uniprot id: Q5PPW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

8355:cwc25.L
gene id: 8355:cwc25.L
uniprot id: Q6DFD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

8355:arpc3.L
gene id: 8355:arpc3.L
uniprot id: A0A8J1KJ75
uniprot id: Q7T0U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

8355:mixer.L
gene id: 8355:mixer.L
uniprot id: A0A8J0V4P2
names: Subcellular Location Annotation
messages: Nucleus

8355:mettl1.L
gene id: 8355:mettl1.L
uniprot id: A0A8J0UAM4
uniprot id: A0A8J1M745
uniprot id: Q6NU94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with WDR4.
messages: Forms a complex with wdr4.
messages: Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs.
messages: Nucleus

8355:tuba5.S
gene id: 8355:tuba5.S
uniprot id: Q7ZTP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

8355:tulp3.L
gene id: 8355:tulp3.L
uniprot id: A0A8J1MH51
uniprot id: Q6DEE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

8355:gpatch1.L
gene id: 8355:gpatch1.L
uniprot id: A0A1L8GL60
names: Similarity
messages: Belongs to the GPATCH1 family.

8355:tpgs1.S
gene id: 8355:tpgs1.S
uniprot id: A0A1L8HNP1
names: Subcellular Location Annotation
messages: Membrane

8355:ndrg1.S
gene id: 8355:ndrg1.S
uniprot id: A0A8J1L0D5
uniprot id: Q7ZWV3
names: Function
names: Similarity
messages: Belongs to the NDRG family.
messages: May be involved in pronephros development, after specification of the pronephros.

8355:psmb7.S
gene id: 8355:psmb7.S
uniprot id: Q68EX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

8355:adh1c.S
gene id: 8355:adh1c.S
uniprot id: Q6P7G1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

8355:lpcat4.S
gene id: 8355:lpcat4.S
uniprot id: Q6DCK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates. Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity).
messages: Endoplasmic reticulum membrane

8355:XB954544.L
gene id: 8355:XB954544.L
uniprot id: A0A1L8F9R9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

8355:lum.S
gene id: 8355:lum.S
uniprot id: A0A1L8GUS2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

8355:LOC108700806
gene id: 8355:LOC108700806
uniprot id: A0A1L8ES29
uniprot id: A0A8J0TV37
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108696863
gene id: 8355:LOC108696863
uniprot id: A0A1L8FPF6
names: Similarity
messages: Belongs to the CAMK2N family.

8355:LOC108695783
gene id: 8355:LOC108695783
uniprot id: A0A8J1L7B7
uniprot id: A0A8J1L8B9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108697784
gene id: 8355:LOC108697784
uniprot id: A0A1L8FH01
names: Subcellular Location Annotation
messages: Cytoplasm

8355:gcm1.S
gene id: 8355:gcm1.S
uniprot id: Q7ZY38
names: Subcellular Location Annotation
messages: Nucleus

8355:nxpe3.L
gene id: 8355:nxpe3.L
uniprot id: A0A1L8HGC2
names: Similarity
messages: Belongs to the NXPE family.

8355:tmem39a.S
gene id: 8355:tmem39a.S
uniprot id: A0A1L8H5I1
uniprot id: Q0IHF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

8355:pknox1.L
gene id: 8355:pknox1.L
uniprot id: Q32NP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

8355:LOC108697469
gene id: 8355:LOC108697469
uniprot id: A0A8J0TEU1
uniprot id: A0A8J1LBQ2
uniprot id: A0A8J1LDA5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:myo9b.L
gene id: 8355:myo9b.L
uniprot id: A0A1L8HXG8
uniprot id: A0A8J1KNN6
uniprot id: A0A8J1KNP8
uniprot id: A0A8J1KQC2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:rpl18.S
gene id: 8355:rpl18.S
uniprot id: Q7SZA4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

8355:rpl27a.S
gene id: 8355:rpl27a.S
uniprot id: P47830
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8355:psma7.L
gene id: 8355:psma7.L
uniprot id: Q9PVY6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: Phosphorylated in G2 phase.
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

8355:sp4-c
gene id: 8355:sp4-c
uniprot id: P24056
names: Developmental Stage
names: Subcellular Location Annotation
messages: Nucleus
messages: SP4 gene is transcribed in or before primary spermatocyte stage but is translated at the round spermatid stage.

8355:tmem121.L
gene id: 8355:tmem121.L
uniprot id: A0A1L8FB36
names: Similarity
messages: Belongs to the TMEM121 family.

8355:mindy2.L
gene id: 8355:mindy2.L
uniprot id: A0A1L8H0J6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

8355:basp1.L
gene id: 8355:basp1.L
uniprot id: Q3KPN5
names: Similarity
messages: Belongs to the BASP1 family.

8355:acot8.S
gene id: 8355:acot8.S
uniprot id: A0A1L8EMC5
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8355:LOC108703855
gene id: 8355:LOC108703855
uniprot id: A0A8J1LTS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:dmgdh.L
gene id: 8355:dmgdh.L
uniprot id: Q2KHP7
names: Similarity
messages: Belongs to the GcvT family.

8355:ugt1a6.S
gene id: 8355:ugt1a6.S
uniprot id: A0A1L8EPI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

8355:dgcr2.L
gene id: 8355:dgcr2.L
uniprot id: A0A1L8I0U2
uniprot id: A0A8J0V5B5
uniprot id: A0A8J0V8I7
uniprot id: A0A8J0V980
uniprot id: A0A8J1L2Z4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:adamts15.S
gene id: 8355:adamts15.S
uniprot id: A0A1L8FFP2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:uba6.L
gene id: 8355:uba6.L
uniprot id: A0A8J1MZ58
uniprot id: A0A8J1N0R2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

8355:rarg.S
gene id: 8355:rarg.S
uniprot id: A0A8J0UKT2
uniprot id: P28699
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Expressed in embryos, tadpoles and various adult tissue such as kidney, testis, brain, liver, skeletal muscle and spleen.
messages: Heterodimer; with a rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.
messages: It is synthesized during oogenesis and persists during early cleavage. It accumulates at gastrulation (stage 10), peaks in quantity during neurulation (stage 17), then drops to a low level after stage 26. Isoform 1 is strongly expressed in branchial arches and to a lesser extent in the neural floor plate, but is not expressed neither in the pre-somitic mesoderm nor notochord. At gastrula stages 10-11, isoform 2 is mainly found in ectoderm and mesoderm with greater expression in the prospective dorsal side. At neurula stage, expressed anteriorly in the head mesoderm and in the archenteron roof. In early tadpole stage, expressed in head mesenchyme and in the tailbud.
messages: Nucleus
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity).

8355:pou3f2.S
gene id: 8355:pou3f2.S
uniprot id: P31365
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Expressed in the developing brain and spinal cord. Also found in a restricted region of the auditory vesicle during development. In the adult, expression is restricted to the brain.
messages: First expressed at the neurula stage.
messages: Nucleus
messages: Transcription factor that may be implicated in patterning of the central nervous system during early development.

8355:LOC121399955
gene id: 8355:LOC121399955
uniprot id: A0A8J1M8F1
uniprot id: A0A8J1M9B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

8355:prr5.L
gene id: 8355:prr5.L
uniprot id: A0A8J0UN24
uniprot id: A0A8J1MGP4
uniprot id: A0A8J1MH90
uniprot id: Q8AVJ1
names: Function
names: Similarity
messages: Belongs to the PROTOR family.
messages: Subunit of TORC2, which regulates cell growth and survival in response to hormonal signals.

8355:fshr.L
gene id: 8355:fshr.L
uniprot id: G9M6I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

8355:htr1a.S
gene id: 8355:htr1a.S
uniprot id: A0A8J0U5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cltb.L
gene id: 8355:cltb.L
uniprot id: A0A8J1MGV6
uniprot id: Q6PA88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

8355:fgfr4.L
gene id: 8355:fgfr4.L
uniprot id: A0A1L8GXW6
uniprot id: Q9PSV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:tmc6.L
gene id: 8355:tmc6.L
uniprot id: A0A1L8ETX5
uniprot id: A0A8J0TS02
uniprot id: Q6GPL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8355:st8sia3.S
gene id: 8355:st8sia3.S
uniprot id: A0A1L8HRW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:capns1.L
gene id: 8355:capns1.L
uniprot id: Q640X7
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates.
messages: Membrane

8355:LOC443660
gene id: 8355:LOC443660
uniprot id: A0A8J1M929
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

8355:arsh.L
gene id: 8355:arsh.L
uniprot id: A0A1L8HDD5
uniprot id: A0A8J1M5I1
uniprot id: Q6DJK3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8355:pdxk.S
gene id: 8355:pdxk.S
uniprot id: A0A1L8H5N1
uniprot id: A0A8J1MCM7
names: Similarity
messages: Belongs to the pyridoxine kinase family.

8355:LOC108703518
gene id: 8355:LOC108703518
uniprot id: A0A8J0TUR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

8355:LOC121400407
gene id: 8355:LOC121400407
uniprot id: A0A8J1MC95
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:megf10.S
gene id: 8355:megf10.S
uniprot id: A0A8J1M4Y2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:znf703.L
gene id: 8355:znf703.L
uniprot id: Q7ZWN6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Cytoplasm
messages: Expressed at the posterior ectoderm except for the dorsal midline in gastrulae (PubMed:28716930). During neurulation, expression diminishes so as to become restricted to the lateral neural plate border (NPB) and neural crest (PubMed:28716930).
messages: Morpholino knockdown blocks differentiation of the neural plate border (NPB).
messages: Nucleus
messages: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters (By similarity). Regulates cell adhesion, migration and proliferation (By similarity). Involved in specification of the lateral neural plate border (NPB) (PubMed:28716930). May be required for segmental gene expression during hindbrain development (By similarity).

8355:uggt1.L
gene id: 8355:uggt1.L
uniprot id: A0A1L8GB77
uniprot id: A0A8J0VCV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

8355:tm9sf2.S
gene id: 8355:tm9sf2.S
uniprot id: Q5U4N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

8355:ppef1.L
gene id: 8355:ppef1.L
uniprot id: A0A1L8HDQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

8355:serbp1.L
gene id: 8355:serbp1.L
uniprot id: A0A1L8GLU2
uniprot id: A0A8J0V233
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:tspan33.S
gene id: 8355:tspan33.S
uniprot id: A0A1L8GTL4
uniprot id: A0A8J1MRE5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:lrp1.L
gene id: 8355:lrp1.L
uniprot id: A0A8J0UGQ9
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108716035
gene id: 8355:LOC108716035
uniprot id: A0A1L8I0D9
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

8355:LOC108710412
gene id: 8355:LOC108710412
uniprot id: A0A8J0UGK0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:mapk8.L
gene id: 8355:mapk8.L
uniprot id: Q8QHK8
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by threonine and tyrosine phosphorylation, potentially by the dual-specificity kinase, MKK7. Indirectly activated by Wnt5a.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
messages: Nucleus
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulating transcriptional activity (By similarity). Regulates morphogenic cell movements, controlling convergent extension during gastrulation. May play a role in the regulation of the circadian clock (By similarity).
messages: Strongly expressed in presumptive ectoderm and mesoderm regions and weakly expressed in endoderm regions during early stages of embryo development. Expressed in the head and dorsal regions during neurula and tailbud stages.
messages: Synapse
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

8355:nog4.S
gene id: 8355:nog4.S
uniprot id: Q2NNB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Secreted

8355:LOC108701942
gene id: 8355:LOC108701942
uniprot id: A0A8J0TPI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:lsm14b.L
gene id: 8355:lsm14b.L
uniprot id: A0A8J0TSB3
uniprot id: Q68FI1
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LSM14 family.
messages: Component of a ribonucleoprotein (RNP) complex, at least composed of cpeb1, lsm14b/rap55b, ddx6/Xp54, ybx2/frgy2, pat1/P100, eif4enif1/4E-T and eif4e1b. Different translationally-repressed mRNP complexes probably exist that contain either lsm14a/rap55a or lsm14b/rap55b depending on the developmental stage. Component of a ribonucleoprotein (RNP) complex, composed at least of elavl1/elrA and/or elavl2/elrB, igf2bp3/vg1RBP, ddx6/Xp54, ybx2/frgy2, lsm14b/rap55b and, in a subset of RNP complexes, stau1/staufen.
messages: Expressed maternally. Expression declines during oocyte maturation.
messages: May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (PubMed:18631138).

8355:LOC108707466
gene id: 8355:LOC108707466
uniprot id: A0A1L8HE11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108706101
gene id: 8355:LOC108706101
uniprot id: A0A8J0U7B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:nucb1.L
gene id: 8355:nucb1.L
uniprot id: A0A1L8FNI7
uniprot id: A0A8J0T8A3
uniprot id: Q63ZJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobindin family.
messages: Cytoplasm
messages: Secreted
messages: cis-Golgi network membrane

8355:stam2.S
gene id: 8355:stam2.S
uniprot id: Q7ZYI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane

8355:slc24a5.L
gene id: 8355:slc24a5.L
uniprot id: A0A1L8H0N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

8355:f3.S
gene id: 8355:f3.S
uniprot id: A0A8J0V031
uniprot id: A0A8J1N1L5
uniprot id: Q5U482
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

8355:emc9.L
gene id: 8355:emc9.L
uniprot id: Q3B8G2
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

8355:LOC121393816
gene id: 8355:LOC121393816
uniprot id: A0A8J1KPT5
uniprot id: A0A8J1KPT9
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:slc30a8.L
gene id: 8355:slc30a8.L
uniprot id: A0A8J0VHT0
uniprot id: A0A8J1KZ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell membrane
messages: Membrane
messages: secretory vesicle membrane

8355:LOC108708224
gene id: 8355:LOC108708224
uniprot id: A0A8J1M8P3
names: Similarity
messages: Belongs to the splicing factor SR family.

8355:LOC108712641
gene id: 8355:LOC108712641
uniprot id: A0A8J0UNZ6
uniprot id: A0A8J0UVM3
uniprot id: A0A8J0UVT2
uniprot id: A0A8J0UZ78
uniprot id: A0A8J1MQE7
uniprot id: A0A8J1MRG1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8355:LOC108703554
gene id: 8355:LOC108703554
uniprot id: A0A8J0U5C1
names: Similarity
messages: Belongs to the NXPE family.

8355:LOC108706515
gene id: 8355:LOC108706515
uniprot id: A0A1L8HKP1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mettl6.S
gene id: 8355:mettl6.S
uniprot id: A0A1L8FRJ4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

8355:LOC108703893
gene id: 8355:LOC108703893
uniprot id: A0A8J0TVL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8355:scarb2.L
gene id: 8355:scarb2.L
uniprot id: Q7ZTL6
names: Similarity
messages: Belongs to the CD36 family.

8355:LOC108702276
gene id: 8355:LOC108702276
uniprot id: A0A8J1M0B4
uniprot id: A0A8J1M0B9
uniprot id: A0A8J1M0E0
uniprot id: A0A8J1M0G9
uniprot id: A0A8J1M0H3
uniprot id: A0A8J1M1J2
uniprot id: A0A8J1M2C7
uniprot id: A0A8J1M2D2
names: Similarity
messages: Belongs to the DIP2 family.

8355:rara.L
gene id: 8355:rara.L
uniprot id: Q92019
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8355:hyls1.S
gene id: 8355:hyls1.S
uniprot id: A0A1L8ER70
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: Morpholino knockdown results in a specific loss of cilia, with no effect on the number of cells with multiple basal bodies or the number of basal bodies per cell.
messages: Plays an important role in ciliogenesis. Required for apical targeting/anchoring of centrioles at the plasma membrane.
messages: centriole
messages: cilium

8355:aipl1.S
gene id: 8355:aipl1.S
uniprot id: A0A1L8H6E0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be important in protein trafficking and/or protein folding and stabilization.
messages: Nucleus

8355:yars1.S
gene id: 8355:yars1.S
uniprot id: A0A8J1MB44
uniprot id: Q7ZX51
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: The nuclear localization signal, which mediates localization to the nucleus, is also important for interacting with tRNA(Tyr), suggesting that it is sterically blocked when tRNA(Tyr) is bound.

8355:atp4b.L
gene id: 8355:atp4b.L
uniprot id: Q66KW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8355:XB5772073.S
gene id: 8355:XB5772073.S
uniprot id: A0A8J0V442
uniprot id: A0A8J0V5D4
uniprot id: Q4V7L3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:mtif3.L
gene id: 8355:mtif3.L
uniprot id: A0A1L8HJ65
names: Similarity
messages: Belongs to the IF-3 family.

8355:c5.2.L
gene id: 8355:c5.2.L
uniprot id: A0A8J1LFH2
uniprot id: A0A8J1LFJ4
names: Subcellular Location Annotation
messages: Secreted

8355:rpl36a.L
gene id: 8355:rpl36a.L
uniprot id: A0A8J1LEM9
uniprot id: Q66KU5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

8355:gpr37.L
gene id: 8355:gpr37.L
uniprot id: A0A1L8GYY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:fkbp6.L
gene id: 8355:fkbp6.L
uniprot id: A0A8J0UEL7
uniprot id: Q6INU1
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

8355:srp54.L
gene id: 8355:srp54.L
uniprot id: A0A1L8FAQ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle
messages: Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits.

8355:arhgef1.L
gene id: 8355:arhgef1.L
uniprot id: A0A8J1L7D3
uniprot id: A0A8J1L7E2
uniprot id: A0A8J1L7F4
uniprot id: A0A8J1L920
uniprot id: A0A8J1L9Z6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

8355:LOC108699040
gene id: 8355:LOC108699040
uniprot id: A0A1L8FBJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121401570
gene id: 8355:LOC121401570
uniprot id: A0A8J1MM65
uniprot id: A0A8J1MN22
names: Similarity
messages: Belongs to the SNF7 family.

8355:atp2a3.L
gene id: 8355:atp2a3.L
uniprot id: A0A8J1M7I1
uniprot id: Q5U4T2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8355:cnn2.L
gene id: 8355:cnn2.L
uniprot id: O93547
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

8355:per1.L
gene id: 8355:per1.L
uniprot id: A0A1L8H3E8
uniprot id: A0A8J0PNA8
uniprot id: A0A8J0UMW2
uniprot id: Q7SZV2
uniprot id: Q9DFU8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:auh.S
gene id: 8355:auh.S
uniprot id: Q4V7P4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

8355:LOC108709060
gene id: 8355:LOC108709060
uniprot id: A0A8J1MHZ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cdk2.L
gene id: 8355:cdk2.L
uniprot id: Q6IRQ7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC398692
gene id: 8355:LOC398692
uniprot id: A0A8J1LA14
uniprot id: Q7T0S6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:mrps12.S
gene id: 8355:mrps12.S
uniprot id: A0A1L8F428
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

8355:cntfr.S
gene id: 8355:cntfr.S
uniprot id: A0A8J1M4J6
uniprot id: A0A8J1M5M8
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

8355:uhrf1.S
gene id: 8355:uhrf1.S
uniprot id: A0A8J1LP39
uniprot id: B6CHA3
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins. However, it is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo.
messages: Nucleus
messages: The RING finger is required for ubiquitin ligase activity.
messages: The YDG domain (also named SRA domain) specifically recognizes and binds hemimethylated DNA at replication forks (DNA that is only methylated on the mother strand of replicating DNA).
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

8355:LOC108711415
gene id: 8355:LOC108711415
uniprot id: A0A1L8H0M8
uniprot id: A0A8J0UK63
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:myod1.L
gene id: 8355:myod1.L
uniprot id: Q6GN48
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8355:coro2b.L
gene id: 8355:coro2b.L
uniprot id: A0A1L8H175
uniprot id: A0A1L8H198
uniprot id: A0A8J1MH42
uniprot id: A0A8J1MJ09
uniprot id: Q6DJD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: May play a role in the reorganization of neuronal actin structure.
messages: cytoskeleton

8355:ryr1.L
gene id: 8355:ryr1.L
uniprot id: A0A1L8F907
uniprot id: A0A8J0TBM1
uniprot id: A0A8J0THT1
uniprot id: A0A8J0TK89
uniprot id: A0A8J0TL64
uniprot id: A0A8J0TL69
uniprot id: A0A8J1LH51
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

8355:sptan1.L
gene id: 8355:sptan1.L
uniprot id: A0A8J1LHN6
uniprot id: A0A8J1LHR9
uniprot id: A0A8J1LHS5
uniprot id: A0A8J1LIB2
uniprot id: A0A8J1LJ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

8355:tmem59l.L
gene id: 8355:tmem59l.L
uniprot id: A0A1L8HX12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC121394610
gene id: 8355:LOC121394610
uniprot id: A0A1L8FWH1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

8355:LOC397944
gene id: 8355:LOC397944
uniprot id: A0A1L8GTE7
uniprot id: A0A8J0UMA5
uniprot id: A0A8J0UT33
uniprot id: A0A8J0UT38
uniprot id: A0A8J0UU62
uniprot id: A0A8J0UU67
uniprot id: A0A8J0UUA7
uniprot id: A0A8J0UUB2
uniprot id: A0A8J0UXL5
uniprot id: A0A8J1MR82
uniprot id: A0A8J1MRD7
uniprot id: A0A8J1MS87
uniprot id: A0A8J1MSH9
uniprot id: A0A8J1MTI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

8355:LOC108718612
gene id: 8355:LOC108718612
uniprot id: A0A8J1KZ64
uniprot id: A0A8J1KZ65
uniprot id: A0A8J1KZ69
uniprot id: A0A8J1KZ75
uniprot id: A0A8J1L0T3
uniprot id: A0A8J1L210
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108712330
gene id: 8355:LOC108712330
uniprot id: A0A8J1MKF0
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108696803
gene id: 8355:LOC108696803
uniprot id: Q68EU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

8355:pax3.S
gene id: 8355:pax3.S
uniprot id: A0A8J0VDK4
uniprot id: A0A8J0VDY1
uniprot id: A0A8J0VET8
uniprot id: A0A8J0VJ83
uniprot id: Q645N4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: By wnt-signaling from the posterior mesoderm.
messages: Expressed in the dorsolateral ectoderm during early and mid-gastrula stages. At late-gastrula and neurula stages, expressed in the lateral neural plate, becoming progressively refined to the neural folds during convergence and extension. Expression is also restricted in the A/P axis, extending into the midbrain but excluded from the forebrain.
messages: Nucleus
messages: Probable transcription factor. Promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. Acts downstream of msx1 to induce the neural crest, cooperating with zic1 and mediating signals from both the wnt and fgf8 signaling pathways. Induction of hatching gland cell fate is independent of zic1.

8355:LOC108715307
gene id: 8355:LOC108715307
uniprot id: A0A1L8GEG2
uniprot id: A0A8J0V542
uniprot id: A0A8J1KI04
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:myo18a.L
gene id: 8355:myo18a.L
uniprot id: A0A8J0U5N4
uniprot id: A0A8J0U5N9
uniprot id: A0A8J0UCL4
uniprot id: A0A8J0UDY8
uniprot id: A0A8J0UGI5
uniprot id: A0A8J1M7H0
uniprot id: A0A8J1M7H1
uniprot id: A0A8J1M7K6
uniprot id: A0A8J1M7L1
uniprot id: A0A8J1M8I7
uniprot id: A0A8J1M8J4
uniprot id: A0A8J1M9B6
uniprot id: A0A8J1M9C0
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mst1r.S
gene id: 8355:mst1r.S
uniprot id: A0A1L8GHC7
uniprot id: A0A8J1KJX8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8355:LOC108699502
gene id: 8355:LOC108699502
uniprot id: A0A1L8F5V6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:taf5.L
gene id: 8355:taf5.L
uniprot id: B1WBA4
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

8355:kcnk18.L
gene id: 8355:kcnk18.L
uniprot id: A0A8J1LAB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:nr1i3.L
gene id: 8355:nr1i3.L
uniprot id: A0A1L8FCY0
uniprot id: A0A8J1LJA6
uniprot id: A0A8J1LKM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8355:LOC108718578
gene id: 8355:LOC108718578
uniprot id: A0A8J1KYG2
uniprot id: A0A8J1L026
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC121397959
gene id: 8355:LOC121397959
uniprot id: A0A1L8EU99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:mrpl40.S
gene id: 8355:mrpl40.S
uniprot id: Q5PPR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

8355:timm13.L
gene id: 8355:timm13.L
uniprot id: B7ZPQ6
uniprot id: Q6GPY0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIMM8 (TIMM8A or TIMM8B) and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of some proteins while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of timm13-A from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

8355:serinc5.S
gene id: 8355:serinc5.S
uniprot id: A0A8J1M580
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

8355:c1orf52.S
gene id: 8355:c1orf52.S
uniprot id: Q5FWN9
names: Similarity
messages: Belongs to the UPF0690 family.

8355:golph3l.L
gene id: 8355:golph3l.L
uniprot id: A0A8J0TDT8
uniprot id: A0JPI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Homooligomer.
messages: Membrane
messages: Phosphatidylinositol-4-phosphate-binding protein that may play a role in the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.
messages: trans-Golgi network membrane

8355:otop3.L
gene id: 8355:otop3.L
uniprot id: A0A8J1LVV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8355:LOC121394111
gene id: 8355:LOC121394111
uniprot id: A0A8J1KTH1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108701341
gene id: 8355:LOC108701341
uniprot id: A0A8J1LR70
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:XB5745823.L
gene id: 8355:XB5745823.L
uniprot id: A2VDC3
names: Similarity
messages: Belongs to the globin family.

8355:hdac3.S
gene id: 8355:hdac3.S
uniprot id: Q6IRL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Cytoplasm
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Also functions as deacetylase for non-histone targets. In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively.
messages: Nucleus

8355:osbpl9.S
gene id: 8355:osbpl9.S
uniprot id: A0A1L8GFV6
uniprot id: A0A1L8GFW4
uniprot id: A0A8J0V2P0
uniprot id: A0A8J0V675
uniprot id: A0A8J0V7J7
uniprot id: A0A8J1KJ93
uniprot id: A0A8J1KJ98
uniprot id: A0A8J1KJA3
uniprot id: A0A8J1KJB1
uniprot id: A0A8J1KJB6
uniprot id: A0A8J1KL00
uniprot id: A0A8J1KL05
uniprot id: A0A8J1KME8
uniprot id: A0A8J1KMF3
names: Similarity
messages: Belongs to the OSBP family.

8355:prxl2a.L
gene id: 8355:prxl2a.L
uniprot id: A0A1L8FK94
uniprot id: Q641F0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm
messages: Involved in redox regulation of the cell. Acts as an antioxidant (By similarity).
messages: The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.

8355:LOC108713157
gene id: 8355:LOC108713157
uniprot id: Q7ZXH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell junction
messages: Cell membrane
messages: Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity).
messages: cytosol

8355:ttc39c.L
gene id: 8355:ttc39c.L
uniprot id: A0A1L8FYQ7
names: Similarity
messages: Belongs to the TTC39 family.

8355:LOC108699401
gene id: 8355:LOC108699401
uniprot id: A0A8J0TDU7
uniprot id: A0A8J1LJM3
uniprot id: A0A8J1LLA4
names: Similarity
messages: Belongs to the MHC class I family.

8355:spic.S
gene id: 8355:spic.S
uniprot id: Q6DCY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:LOC121393126
gene id: 8355:LOC121393126
uniprot id: A0A8J1LZB1
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108702178
gene id: 8355:LOC108702178
uniprot id: A0A1L8EL38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:nmur1.S
gene id: 8355:nmur1.S
uniprot id: A0A1L8G440
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

8355:fcn1.S
gene id: 8355:fcn1.S
uniprot id: Q7ZT72
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ficolin lectin family.
messages: Expressed in peripheral blood leukocytes. Also detected at lower levels in spleen and lung.
messages: Homotrimer. May form higher-order oligomers.
messages: May function in innate immunity through activation of the lectin complement pathway. Binds to GalNAc and GlcNAc carbohydrate moieties.
messages: N-glycosylated.
messages: Secreted
messages: The fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates. The domain undergoes a conformational switch at pH under 6.2, and loses its carbohydrate-binding ability.

8355:ppm1a.S
gene id: 8355:ppm1a.S
uniprot id: Q8AVG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

8355:uxs1.L
gene id: 8355:uxs1.L
uniprot id: A0A1L8HGM0
uniprot id: A0A8J0UFN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

8355:LOC108713752
gene id: 8355:LOC108713752
uniprot id: A0A1L8GIL1
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108705162
gene id: 8355:LOC108705162
uniprot id: A0A1L8G0S8
uniprot id: P62799
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
messages: Belongs to the histone H4 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation.
messages: Chromosome
messages: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by KMT5A/SET8. Trimethylation is performed by KMT5B and KMT5C and induces gene silencing. Monomethylated at Lys-13 (H4K12me1) by N6AMT1; H4K12me1 modification is present at the promoters of numerous genes encoding cell cycle regulators.
messages: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity).
messages: Nucleus
messages: Phosphorylated by pak2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4 (By similarity).
messages: Sumoylated, which is associated with transcriptional repression.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me) (By similarity).
messages: Ufmylated; monofmylated by UFL1 at Lys-32 (H4K31Ufm1) in response to DNA damage.

8355:kcnk10.S
gene id: 8355:kcnk10.S
uniprot id: A0A1L8F0H8
uniprot id: A0A8J0TNG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:egflam.S
gene id: 8355:egflam.S
uniprot id: A0A1L8HRS5
uniprot id: A0A8J0U9U7
uniprot id: A0A8J1M492
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:gast.S
gene id: 8355:gast.S
uniprot id: A0A1L8EKG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

8355:gstz1.L
gene id: 8355:gstz1.L
uniprot id: A0A8J0THW0
uniprot id: Q3B8M0
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

8355:il1b.L
gene id: 8355:il1b.L
uniprot id: A0A8J1MMF6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Lysosome
messages: Monomer.
messages: cytosol
messages: extracellular exosome

8355:osbpl6.S
gene id: 8355:osbpl6.S
uniprot id: A0A1L8EPC2
uniprot id: A0A8J1M0B5
uniprot id: A0A8J1M1G6
names: Similarity
messages: Belongs to the OSBP family.

8355:LOC108709129
gene id: 8355:LOC108709129
uniprot id: A0A1L8H9S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

8355:fyn.L
gene id: 8355:fyn.L
uniprot id: A0A1L8G8Y4
uniprot id: A0A8J0V922
uniprot id: P13406
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Expressed in early tail-bud embryos at stage 20 in the brain region of the neural tube and at lower levels throughout the remaining length of the neural tube. Present at stage 32 in the forebrain, midbrain, the ventral half of the hindbrain and the spinal cord.
messages: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
messages: Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels (By similarity). Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by ntn1 by phosphorylating its receptor ddc.

8355:LOC108711365
gene id: 8355:LOC108711365
uniprot id: A0A1L8H0C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

8355:ctnnal1.S
gene id: 8355:ctnnal1.S
uniprot id: Q6DEE3
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

8355:arhgef7.L
gene id: 8355:arhgef7.L
uniprot id: A0A1L8HH17
uniprot id: A0A8J1M9E6
uniprot id: A0A8J1M9E7
uniprot id: A0A8J1M9P4
uniprot id: A0A8J1MAF7
names: Subcellular Location Annotation
messages: lamellipodium

8355:gdf7.S
gene id: 8355:gdf7.S
uniprot id: Q9DGN4
names: Similarity
messages: Belongs to the TGF-beta family.

8355:awat1.S
gene id: 8355:awat1.S
uniprot id: A0A8J1KR46
uniprot id: A0A8J1KR67
uniprot id: A9JS91
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:casp7.L
gene id: 8355:casp7.L
uniprot id: Q9IB65
names: Similarity
messages: Belongs to the peptidase C14A family.

8355:LOC108714107
gene id: 8355:LOC108714107
uniprot id: A0A8J0UW04
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8355:tcf25.L
gene id: 8355:tcf25.L
uniprot id: A3KMT4
names: Similarity
messages: Belongs to the TCF25 family.

8355:mark3.L
gene id: 8355:mark3.L
uniprot id: A0A8J1LED8
uniprot id: A0A8J1LEE5
uniprot id: A0A8J1LEF0
uniprot id: A0A8J1LER6
uniprot id: A0A8J1LFV1
uniprot id: A0A8J1LFV6
uniprot id: A0A8J1LGU3
uniprot id: A0A8J1LGU8
uniprot id: Q804T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

8355:soga1.S
gene id: 8355:soga1.S
uniprot id: A0A1L8EMT7
uniprot id: A0A8J0TZQ1
names: Similarity
messages: Belongs to the SOGA family.

8355:nsmce4a.L
gene id: 8355:nsmce4a.L
uniprot id: B1WBD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

8355:stt3a.S
gene id: 8355:stt3a.S
uniprot id: A0A1L8FFS2
uniprot id: A0A8J0T6G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

8355:dkk1.S
gene id: 8355:dkk1.S
uniprot id: O57464
names: Similarity
messages: Belongs to the dickkopf family.

8355:LOC121402875
gene id: 8355:LOC121402875
uniprot id: A0A8J1MUK6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:cdv3.S
gene id: 8355:cdv3.S
uniprot id: Q7ZYA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDV3 family.
messages: Cytoplasm

8355:prdx6.S
gene id: 8355:prdx6.S
uniprot id: Q7SYQ4
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

8355:npy2r.S
gene id: 8355:npy2r.S
uniprot id: B7ZQ80
uniprot id: P34992
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY.

8355:susd2.S
gene id: 8355:susd2.S
uniprot id: A0A1L8HQW6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108717481
gene id: 8355:LOC108717481
uniprot id: A0A1L8G505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:LOC108717901
gene id: 8355:LOC108717901
uniprot id: A0A1L8G2M1
uniprot id: A0A8J0VF51
uniprot id: A0A8J1KT39
uniprot id: A0A8J1KT46
uniprot id: A0A8J1KUP5
names: Similarity
messages: Belongs to the TCP10 family.

8355:XB5731323.S
gene id: 8355:XB5731323.S
uniprot id: A0A1L8GGI5
uniprot id: A0A8J0V525
uniprot id: Q6DCZ4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

8355:LOC108710252
gene id: 8355:LOC108710252
uniprot id: A0A8J0UMX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

8355:LOC121393083
gene id: 8355:LOC121393083
uniprot id: A0A8J1MNC1
uniprot id: A0A8J1MQF3
names: Similarity
messages: Belongs to the NXPE family.

8355:pisd.L
gene id: 8355:pisd.L
uniprot id: A0A1L8I0B8
uniprot id: A0A8J0U9V0
uniprot id: A0A8J0UKQ4
uniprot id: Q640X5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

8355:lpar6.L
gene id: 8355:lpar6.L
uniprot id: L0RJ21
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:afap1l2.L
gene id: 8355:afap1l2.L
uniprot id: Q6PF55
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with src.
messages: May play a role in a signaling cascade by enhancing the kinase activity of src. Contributes to src-regulated transcription activation (By similarity).

8355:LOC108715377
gene id: 8355:LOC108715377
uniprot id: A0A1L8GEJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: cilium

8355:ano9.L
gene id: 8355:ano9.L
uniprot id: A0A1L8GJ43
uniprot id: A0A8J0UUQ9
uniprot id: A0A8J0UZF7
uniprot id: A0A8J0V0L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

8355:LOC121399044
gene id: 8355:LOC121399044
uniprot id: A0A1L8EMT6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:tfcp2l1.S
gene id: 8355:tfcp2l1.S
uniprot id: Q6PCK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

8355:LOC121399464
gene id: 8355:LOC121399464
uniprot id: A0A8J1M4C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:nfib.L
gene id: 8355:nfib.L
uniprot id: A0A1L8HYD7
uniprot id: A0A8J0UJ78
uniprot id: A0A8J0UNC3
uniprot id: A0A8J1M9Y5
uniprot id: A0A8J1MBR5
uniprot id: Q91797
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8355:mitf.L
gene id: 8355:mitf.L
uniprot id: Q76DN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

8355:traf6.L
gene id: 8355:traf6.L
uniprot id: Q6DJN2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Cytoplasm
messages: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation.
messages: Homotrimer. Homooligomer.
messages: Lipid droplet
messages: Nucleus
messages: The MATH/TRAF domain binds to receptor cytoplasmic domains.
messages: The coiled coil domain mediates homo- and hetero-oligomerization.
messages: cell cortex

8355:tshz2.S
gene id: 8355:tshz2.S
uniprot id: A0A8J0TZ47
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

8355:cep170.S
gene id: 8355:cep170.S
uniprot id: A0A8J0VKT0
names: Similarity
messages: Belongs to the CEP170 family.

8355:atp6v0d2.L
gene id: 8355:atp6v0d2.L
uniprot id: A0A1L8FZE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8355:por.L
gene id: 8355:por.L
uniprot id: Q6PCH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

8355:abhd2.L
gene id: 8355:abhd2.L
uniprot id: A0A8J1MMY1
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

8355:LOC108698755
gene id: 8355:LOC108698755
uniprot id: A0A1L8HTZ4
uniprot id: A0A8J0TLQ4
uniprot id: A0A8J1MUH3
names: Similarity
messages: Belongs to the peptidase C14A family.

8355:c8g.S
gene id: 8355:c8g.S
uniprot id: A0A8J0TQL1
names: Subcellular Location Annotation
messages: Secreted

8355:nck1.S
gene id: 8355:nck1.S
uniprot id: Q32NQ4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

8355:cep170.L
gene id: 8355:cep170.L
uniprot id: A0A1L8G8D0
uniprot id: A0A8J0VB78
uniprot id: A0A8J0VG66
uniprot id: A0A8J1KPT2
names: Similarity
messages: Belongs to the CEP170 family.

8355:pi4ka.S
gene id: 8355:pi4ka.S
uniprot id: A0A8J0PZ67
uniprot id: A0A8J1LPQ1
uniprot id: Q6DDG3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8355:cul4a.S
gene id: 8355:cul4a.S
uniprot id: A0A1L8H8X2
names: Similarity
messages: Belongs to the cullin family.

8355:LOC121401304
gene id: 8355:LOC121401304
uniprot id: A0A8J1MIP7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:LOC121398224
gene id: 8355:LOC121398224
uniprot id: A0A8J1LUM4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:calcoco1.S
gene id: 8355:calcoco1.S
uniprot id: Q9DEX1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALCOCO family.
messages: Cytoplasm
messages: Expressed in the germinal vesicle of oocytes at stages I-III. Expressed in ectodermal and mesodermal cells and their derivatives after stage 10. At stages later than 28, highly expressed in the myotome, spinal cord and notochord (at protein level).
messages: May function as a coactivator for aryl hydrocarbon and nuclear receptors.
messages: Nucleus

8355:cadm3.L
gene id: 8355:cadm3.L
uniprot id: A0A1L8FBN7
uniprot id: A0A8J0TM80
names: Similarity
messages: Belongs to the nectin family.

8355:LOC108698465
gene id: 8355:LOC108698465
uniprot id: A0A1L8F7T6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:mrpl41.L
gene id: 8355:mrpl41.L
uniprot id: Q6DJI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle (By similarity).
messages: Mitochondrion

8355:man2b2.L
gene id: 8355:man2b2.L
uniprot id: A0A1L8HT80
uniprot id: A0A8J0TFW4
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

8355:vti1b.S
gene id: 8355:vti1b.S
uniprot id: A0A1L8H759
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

8355:LOC108695976
gene id: 8355:LOC108695976
uniprot id: A0A1L8FHW6
uniprot id: A0A8J0T911
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ptch1.L
gene id: 8355:ptch1.L
uniprot id: A0A1L8HYE8
uniprot id: A0A8J0V811
uniprot id: A0A8J1KT08
uniprot id: A0A8J1KT16
uniprot id: A0A8J1KW55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

8355:grpel1.L
gene id: 8355:grpel1.L
uniprot id: Q4V7U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

8355:chrm2.L
gene id: 8355:chrm2.L
uniprot id: A0A8J0U760
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

8355:slc7a7.L
gene id: 8355:slc7a7.L
uniprot id: Q6IP77
names: Subcellular Location Annotation
messages: Membrane

8355:dck.1.S
gene id: 8355:dck.1.S
uniprot id: A0A8J1LRT4
uniprot id: Q5QKN1
names: Similarity
messages: Belongs to the DCK/DGK family.

8355:gnao1.S
gene id: 8355:gnao1.S
uniprot id: P10825
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear.

8355:anapc10.S
gene id: 8355:anapc10.S
uniprot id: Q5EAZ2
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

8355:satb2.L
gene id: 8355:satb2.L
uniprot id: A0A8J1LRI6
uniprot id: A0A8J1LSV1
uniprot id: A0A8J1LTU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

8355:ccr9.L
gene id: 8355:ccr9.L
uniprot id: A0A8J0VNW0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108713270
gene id: 8355:LOC108713270
uniprot id: A0A1L8GV89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

8355:nek9.L
gene id: 8355:nek9.L
uniprot id: A0A8J0TEE8
uniprot id: Q6DKD3
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

8355:cks1b.L
gene id: 8355:cks1b.L
uniprot id: A3KMU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

8355:vip.S
gene id: 8355:vip.S
uniprot id: A0A1L8G264
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

8355:fmo3.L
gene id: 8355:fmo3.L
uniprot id: A0A1L8GN41
uniprot id: A0A8J1MYY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

8355:irx4.L
gene id: 8355:irx4.L
uniprot id: Q90XW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephros kidney development.
messages: Belongs to the TALE/IRO homeobox family.
messages: Expressed in the neural plate in overlapping patterns with other irx members, which all share an anterior border of expression. At stage 20, expressed in a subset of cells in the developing hindbrain with expression appearing above the otic vesicle by stage 26. Expression in retina cells begins at stage 28, continuing at later stages and is limited to a subset of retinal cells of the optic cup. Also expressed in the ventricle of the heart from stage 36 (late tailbud) onwards. Only expressed in the pronephros at tadpole stage.
messages: Nucleus

8355:c19orf53.L
gene id: 8355:c19orf53.L
uniprot id: A0A1L8H361
names: Similarity
messages: Belongs to the UPF0390 family.

8355:cstf3.S
gene id: 8355:cstf3.S
uniprot id: Q6DDM9
names: Subcellular Location Annotation
messages: Nucleus

8355:cfap20.S
gene id: 8355:cfap20.S
uniprot id: Q6GPY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP20 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility (By similarity). Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity).
messages: Nucleus
messages: centriole
messages: cilium axoneme
messages: cilium basal body

8355:LOC108709709
gene id: 8355:LOC108709709
uniprot id: A0A1L8H8N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

8355:hgf.S
gene id: 8355:hgf.S
uniprot id: A0A1L8GTY1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

8355:clip3.S
gene id: 8355:clip3.S
uniprot id: Q5U243
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics (By similarity).
messages: Golgi stack
messages: Homodimer.
messages: Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD).
messages: The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required.

8355:gtpbp1.L
gene id: 8355:gtpbp1.L
uniprot id: A0A8J0V2Z4
names: Function
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

8355:LOC121401335
gene id: 8355:LOC121401335
uniprot id: A0A8J1MIT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sctr.L
gene id: 8355:sctr.L
uniprot id: A0A8J1LPB7
uniprot id: F8RUA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8355:coa7.L
gene id: 8355:coa7.L
uniprot id: A0A8J0UZA0
uniprot id: Q66KY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: May be required for assembly of mitochondrial respiratory chain complexes.
messages: Mitochondrion intermembrane space

8355:LOC108696075
gene id: 8355:LOC108696075
uniprot id: A0A8J0T0F3
uniprot id: A0A8J0T761
uniprot id: A0A8J1L9B8
uniprot id: A0A8J1LBU0
names: Similarity
messages: Belongs to the FAM13 family.

8355:cdk15.L
gene id: 8355:cdk15.L
uniprot id: A0A1L8EWW8
uniprot id: A0A8J0TV46
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:grk1.L
gene id: 8355:grk1.L
uniprot id: A0A1L8HGX8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:gabarapl1.L
gene id: 8355:gabarapl1.L
uniprot id: A0A1L8FEA0
names: Similarity
messages: Belongs to the ATG8 family.

8355:fbp2.L
gene id: 8355:fbp2.L
uniprot id: Q66IR7
names: Similarity
messages: Belongs to the FBPase class 1 family.

8355:zup1.S
gene id: 8355:zup1.S
uniprot id: A0A8J0VDQ7
uniprot id: Q6DF95
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

8355:hint2.S
gene id: 8355:hint2.S
uniprot id: A0A310TQF6
uniprot id: Q6NTS0
names: Similarity
messages: Belongs to the HINT family.

8355:LOC108717281
gene id: 8355:LOC108717281
uniprot id: A0A8J1KSN5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:galnt6.1.S
gene id: 8355:galnt6.1.S
uniprot id: A0A1L8HA39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:gsg1l.S
gene id: 8355:gsg1l.S
uniprot id: A0A1L8FGT3
uniprot id: A0A8J1LBT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

8355:insrr.S
gene id: 8355:insrr.S
uniprot id: A0A1L8F4K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

8355:stx1a.S
gene id: 8355:stx1a.S
uniprot id: A0A8J1MD63
uniprot id: A0A8J1MDQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

8355:csnk2b.L
gene id: 8355:csnk2b.L
uniprot id: P28021
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Casein kinase II/CK2 is a tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions.
messages: Phosphorylated by alpha subunit.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Participates in Wnt signaling.

8355:wnt1.S
gene id: 8355:wnt1.S
uniprot id: A0A1L8H9S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:pheta2.L
gene id: 8355:pheta2.L
uniprot id: A0A1L8GNH6
uniprot id: Q6NRS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

8355:sft2d1.S
gene id: 8355:sft2d1.S
uniprot id: A0A1L8G2G3
uniprot id: A0A8J0VGB3
uniprot id: A0A8J1KSZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

8355:LOC108717704
gene id: 8355:LOC108717704
uniprot id: A0A1L8G189
uniprot id: A0A8J0VEP3
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121393903
gene id: 8355:LOC121393903
uniprot id: A0A8J1KQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

8355:LOC108714283
gene id: 8355:LOC108714283
uniprot id: A0A1L8GM74
uniprot id: A0A8J0V230
uniprot id: A0A8J1MWX7
uniprot id: A0A8J1MX68
uniprot id: A0A8J1MY40
uniprot id: A0A8J1MYM7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

8355:kcnh4.S
gene id: 8355:kcnh4.S
uniprot id: A0A8J1LYW6
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

8355:LOC108707084
gene id: 8355:LOC108707084
uniprot id: A0A1L8HQ23
uniprot id: A0A8J0UA59
uniprot id: A0A8J1M4H3
names: Similarity
messages: Belongs to the RUTBC family.

8355:kdm3b.L
gene id: 8355:kdm3b.L
uniprot id: A0A1L8GY40
uniprot id: A0A8J0UPD7
names: Subcellular Location Annotation
messages: Nucleus

8355:usp37.S
gene id: 8355:usp37.S
uniprot id: A0A1L8ENU6
uniprot id: A0A8J0TSZ3
uniprot id: A0A8J0U096
uniprot id: A0A8J0U0E9
uniprot id: A0A8J0U0F5
uniprot id: A0A8J0U3B5
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:nos2.L
gene id: 8355:nos2.L
uniprot id: A0A8J0UGX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

8355:thbs4.L
gene id: 8355:thbs4.L
uniprot id: Q06441
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and may be involved in various processes including cellular proliferation, migration, adhesion and attachment. May play a role in ER stress response (By similarity). May participate in the genesis and function of cardiac and skeletal muscle.
messages: Belongs to the thrombospondin family.
messages: Endoplasmic reticulum
messages: Homotrimer; disulfide-linked.
messages: Initial expression during neurulation. Increase during tailbud stages but decrease by the feeding tadpole stage.
messages: Sarcoplasmic reticulum
messages: Secreted
messages: extracellular matrix
messages: extracellular space

8355:aldh7a1.L
gene id: 8355:aldh7a1.L
uniprot id: Q66J16
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

8355:phyhipl.S
gene id: 8355:phyhipl.S
uniprot id: A0A8J1LAD6
uniprot id: Q6AX58
names: Function
names: Similarity
messages: Belongs to the PHYHIP family.
messages: May play a role in the development of the central system.

8355:tmem150a.S
gene id: 8355:tmem150a.S
uniprot id: A0A1L8GS26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

8355:srrt.S
gene id: 8355:srrt.S
uniprot id: A0A8J0U1N0
uniprot id: B1H1X4
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity).
messages: Belongs to the ARS2 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Cytoplasm
messages: Interacts ncbp1/cbp80.
messages: nucleoplasm

8355:pik3cb.S
gene id: 8355:pik3cb.S
uniprot id: A0A1L8G4U9
uniprot id: A0A8J1KXE7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

8355:LOC108709490
gene id: 8355:LOC108709490
uniprot id: A0A8J1MDN6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC121398266
gene id: 8355:LOC121398266
uniprot id: A0A8J1LVT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cdadc1.S
gene id: 8355:cdadc1.S
uniprot id: A0A1L8HAE1
uniprot id: A0A8J0ULY8
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

8355:myd88.L
gene id: 8355:myd88.L
uniprot id: Q9DF60
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (By similarity). Activates expression of target genes in the Spemann organizer region during early embryonic development. Is required for normal axis formation.
messages: Cytoplasm
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.

8355:LOC108712226
gene id: 8355:LOC108712226
uniprot id: A0A8J0UMJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

8355:slc7a13.S
gene id: 8355:slc7a13.S
uniprot id: Q6PAW4
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108699851
gene id: 8355:LOC108699851
uniprot id: A0A8J0TQH7
names: Similarity
messages: Belongs to the UXT family.

8355:kpna6.L
gene id: 8355:kpna6.L
uniprot id: A0A8J0UF40
uniprot id: Q70PC5
names: Similarity
messages: Belongs to the importin alpha family.

8355:tmem50b.L
gene id: 8355:tmem50b.L
uniprot id: Q7T0Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

8355:LOC108700184
gene id: 8355:LOC108700184
uniprot id: A0A1L8F3B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

8355:aadac.L
gene id: 8355:aadac.L
uniprot id: A0A1L8GAW4
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

8355:LOC108697641
gene id: 8355:LOC108697641
uniprot id: A0A8J0TFI4
uniprot id: A0A8J1LCU3
uniprot id: A0A8J1LD38
uniprot id: A0A8J1LEE4
uniprot id: A0A8J1LFC0
names: Similarity
messages: Belongs to the DSH family.

8355:epor.L
gene id: 8355:epor.L
uniprot id: Q4W815
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Cell membrane
messages: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases (By similarity).
messages: Expressed in the ventral blood island from stage 28 through to stage 36. Expressed in the circulating blood by stage 40. In the adult, highly expressed in peripheral blood cells including immature erythrocytes and basophils, and moderately expressed in the hematopoietic organs: liver, kidney and spleen. Expressed at a low level in adult brain.
messages: First expressed at a low level at stage 18 (late neurula), with high levels of expression seen from stage 32 through to stage 48 (tadpole).
messages: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation.
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.

8355:LOC108705624
gene id: 8355:LOC108705624
uniprot id: A0A8J0U9Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ctsc.S
gene id: 8355:ctsc.S
uniprot id: A0A1L8HAZ7
names: Similarity
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

8355:banf1.S
gene id: 8355:banf1.S
uniprot id: Q66KV4
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: At the early gastrula stage, expressed mainly in the entire animal hemisphere. During neurulation, its expression becomes restricted to the anterior neuroectoderm. At the tailbud stage, expressed in various anterior regions including the anterior central nervous system (CNS), otic vesicles, and branchial arches.
messages: Belongs to the BAF family.
messages: Chromosome
messages: Cytoplasm
messages: Has a helix-hairpin-helix (HhH) structural motif conserved among proteins that bind non-specifically to DNA.
messages: Homodimer (By similarity). Interacts with nemp1a and nemp1b (PubMed:19167377).
messages: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA. Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging. Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner. Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface. Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity. Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses. Also involved in DNA damage response; acts by inhibiting the ADP-ribosyltransferase activity of PARP1. Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy.
messages: Nucleus
messages: Nucleus envelope

8355:LOC108708445
gene id: 8355:LOC108708445
uniprot id: A0A1L8HGX7
uniprot id: A0A8J0UIM3
names: Subcellular Location Annotation
messages: Nucleus

8355:pcid2.S
gene id: 8355:pcid2.S
uniprot id: Q5FWP8
names: Similarity
messages: Belongs to the CSN12 family.

8355:tff3.1.S
gene id: 8355:tff3.1.S
uniprot id: Q00222
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: May act as a growth factor.
messages: Secreted
messages: Stomach mucosa.

8355:aldh1l2.S
gene id: 8355:aldh1l2.S
uniprot id: A0A1L8GUQ3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

8355:LOC108703061
gene id: 8355:LOC108703061
uniprot id: A0A8J0U3V5
uniprot id: A0A8J1M047
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

8355:gdf9.L
gene id: 8355:gdf9.L
uniprot id: A0A1L8GXJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

8355:asic4.S
gene id: 8355:asic4.S
uniprot id: A0A1L8ENR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

8355:LOC108697348
gene id: 8355:LOC108697348
uniprot id: A0A1L8FDZ1
uniprot id: A0A8J0T5H9
uniprot id: A0A8J0TEB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

8355:LOC108715750
gene id: 8355:LOC108715750
uniprot id: A0A8J0V852
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108696027
gene id: 8355:LOC108696027
uniprot id: A0A8J1LAS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

8355:eda2r.L
gene id: 8355:eda2r.L
uniprot id: A0A8J0U473
uniprot id: A0A8J0U4U8
uniprot id: A0A8J1LGS6
uniprot id: A0A8J1LHN8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108695724
gene id: 8355:LOC108695724
uniprot id: A0A8J0T8S3
names: Similarity
messages: Belongs to the Toll-like receptor family.

8355:slc35f4.L
gene id: 8355:slc35f4.L
uniprot id: A0A1L8FAB0
uniprot id: A0A8J0TKC4
uniprot id: A0A8J1LIZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

8355:kcnf1.L
gene id: 8355:kcnf1.L
uniprot id: A0A1L8GBL9
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108717215
gene id: 8355:LOC108717215
uniprot id: A0A1L8GCA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:osbpl1a.L
gene id: 8355:osbpl1a.L
uniprot id: A0A1L8FYQ6
uniprot id: A0A8J0VHI3
uniprot id: A0A8J0VL52
uniprot id: A0A8J1L014
names: Similarity
messages: Belongs to the OSBP family.

8355:gjd3.S
gene id: 8355:gjd3.S
uniprot id: A0A1L8EKM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:LOC108717032
gene id: 8355:LOC108717032
uniprot id: A0A1L8GAR4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:hsd17b7.S
gene id: 8355:hsd17b7.S
uniprot id: Q498H1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

8355:sec22b.S
gene id: 8355:sec22b.S
uniprot id: A0A8J0UZH3
uniprot id: A0A8J0V3F8
uniprot id: Q7SYR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

8355:nus1.S
gene id: 8355:nus1.S
uniprot id: A0A1L8G2P1
names: Similarity
messages: Belongs to the UPP synthase family.

8355:LOC108695308
gene id: 8355:LOC108695308
uniprot id: A0A1L8FSZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sfrpx.S
gene id: 8355:sfrpx.S
uniprot id: A0A8J0U9H4
uniprot id: A0A8J1MBY1
uniprot id: Q0IHH5
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:fastkd1.L
gene id: 8355:fastkd1.L
uniprot id: Q6GQ66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAST kinase family.
messages: May regulate the stability of some mitochondrial mRNA species.
messages: Mitochondrion
messages: The RAP domain seems to regulate mitochondrial mRNA levels.

8355:alg2.L
gene id: 8355:alg2.L
uniprot id: Q6DDS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

8355:LOC108711413
gene id: 8355:LOC108711413
uniprot id: A0A1L8H0L8
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

8355:atp1a2.L
gene id: 8355:atp1a2.L
uniprot id: A0A1L8FCN1
uniprot id: A0A8J0TK88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8355:mmp24.S
gene id: 8355:mmp24.S
uniprot id: A0A1L8EMN6
names: Similarity
messages: Belongs to the peptidase M10A family.

8355:mterf4.L
gene id: 8355:mterf4.L
uniprot id: A0A1L8GB88
names: Similarity
messages: Belongs to the mTERF family.

8355:tgfa.L
gene id: 8355:tgfa.L
uniprot id: Q5PPZ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rpl30.L
gene id: 8355:rpl30.L
uniprot id: Q6GNF2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

8355:sbk3.S
gene id: 8355:sbk3.S
uniprot id: A0A1L8FGL6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:sap30l.S
gene id: 8355:sap30l.S
uniprot id: Q7ZXP2
names: Similarity
messages: Belongs to the SAP30 family.

8355:trpm8b.L
gene id: 8355:trpm8b.L
uniprot id: A0A1L8EWM8
uniprot id: A0A8J0TQC7
uniprot id: C5IJY8
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108713484
gene id: 8355:LOC108713484
uniprot id: A0A8J1MVX4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

8355:LOC108697779
gene id: 8355:LOC108697779
uniprot id: A0A1L8FH06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

8355:LOC108702564
gene id: 8355:LOC108702564
uniprot id: A0A8J0TZ04
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

8355:rlim.S
gene id: 8355:rlim.S
uniprot id: Q641J8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as an E3 ubiquitin-protein ligase specific for ldb1, mediating ubiquitination and proteasome-dependent degradation of excess ldb1 in a RING-dependent manner. Does not degrade ldb1 bound to lhx1/lim1, nor lim1 itself and thus contributes to the establishment of proper ldb1-lhx1/lim1 stoichiometry and the formation of a ldb1-lhx1/lim1 complex. Interferes with Spemann organizer function and suppresses secondary axis formation induced by ldb1 and lhx1/lim1.
messages: Belongs to the RNF12 family.
messages: Expressed both maternally and zygotically. Expressed at the cleavage stage, with expression disappearing at the gastrula stage.
messages: Forms homodimers through the C-terminal region. The N-terminus interacts with the homeobox of LIM/homeobox factor lhx1/lim1, with lhx3/lim3 and lhx5/lim5, and with the N-terminus of ldb1.
messages: Nucleus
messages: Shows overlapping expression with lhx1/lim1 and ldb1 in the gastrula mesoderm, and expression overlaps with ldb1 throughout early embryogenesis. After gastrulation, expression is gradually restricted to tissues originated from the ectoderm, the neuroectoderm, neural crest and epidermis, and subsequently to the neural tube as well as the head and tailbud region.

8355:clic4.L
gene id: 8355:clic4.L
uniprot id: A0A8J1M6S6
uniprot id: Q6DFA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

8355:cyp1a1.L
gene id: 8355:cyp1a1.L
uniprot id: Q9YI88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8355:tmem30b.L
gene id: 8355:tmem30b.L
uniprot id: Q6NRF6
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

8355:acot2.L
gene id: 8355:acot2.L
uniprot id: A0A1L8FAK3
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

8355:htra2.S
gene id: 8355:htra2.S
uniprot id: A0A1L8HK51
names: Similarity
messages: Belongs to the peptidase S1C family.

8355:ccdc47.S
gene id: 8355:ccdc47.S
uniprot id: Q6AZI2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum membrane
messages: Heteromeric complex composed of WDR83OS/Asterix and CCDC47. Component of the ribosome-associated ER translocon complex.
messages: Necessary for the biogenesis, correct folding and transport of multi-pass membrane proteins into the endoplasmic reticulum (ER) membrane. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation) pathway.
messages: Rough endoplasmic reticulum membrane

8355:elapor2.S
gene id: 8355:elapor2.S
uniprot id: A0A1L8GTU1
uniprot id: A0A8J1MSS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

8355:lmbrd2.L
gene id: 8355:lmbrd2.L
uniprot id: Q7ZYA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: May associate with G-protein coupled receptors and regulate downstream signaling pathways.

8355:LOC108711464
gene id: 8355:LOC108711464
uniprot id: A0A8J0USL9
uniprot id: A0A8J1MMX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:mcm4.S
gene id: 8355:mcm4.S
uniprot id: A0A1L8FSY2
uniprot id: Q5XK83
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Component of the mcm2-7 complex (RLF-M) (PubMed:9214646, PubMed:9214647). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (PubMed:9214646, PubMed:9214647). The heterodimer of mmcm3/mcm5 interacts with mcm4, mmcm6, mcm7 and weakly with mcm2 (PubMed:9214646, PubMed:9214647). Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45 (PubMed:30979826, PubMed:30842657).
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Hyperphosphorylated during mitosis in a mechanism requiring cdc2-cyclin B and other kinases. Undergoes dephosphorylation after exiting mitosis, existing in a partially phosphorylated state in the cytosolic interphase mcm complex which associates with the pre-replication complexes (pre-Rcs). Complete dephosphorylation inactivates the mcm complex, preventing its binding to chromatin. Becomes actively phosphorylated during S phase once the mcm complex is assembled on the chromatin. This chromatin-associated phosphorylation occurs during the activation of the pre-Rcs and is independent of cdks (By similarity). Phosphorylated by the cdc7-dbf4b complex.
messages: Nucleus

8355:ndnfl1.1.S
gene id: 8355:ndnfl1.1.S
uniprot id: A0A1L8GRB2
names: Subcellular Location Annotation
messages: Secreted

8355:LOC108717646
gene id: 8355:LOC108717646
uniprot id: Q92130
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:cnih1.L
gene id: 8355:cnih1.L
uniprot id: A0A8J1LEN4
uniprot id: Q66KH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

8355:cat.3.S
gene id: 8355:cat.3.S
uniprot id: A0A8J0V176
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

8355:LOC108697433
gene id: 8355:LOC108697433
uniprot id: A0A8J0TEP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

8355:aldh1a3.L
gene id: 8355:aldh1a3.L
uniprot id: Q58YE0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8355:LOC108697169
gene id: 8355:LOC108697169
uniprot id: A0A1L8FE33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cxcr4.S
gene id: 8355:cxcr4.S
uniprot id: Q7ZXJ7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome
messages: Late endosome
messages: Lysosome
messages: Monomer. Can form dimers (By similarity).
messages: Nucleus
messages: O- and N-glycosylated.
messages: Receptor for the C-X-C chemokine cxcl12/sdf-1. Transduces a signal by increasing the intracellular level of calcium ions. Signaling with cxcl12/sdf-1 mediates the directional movement of mesodermal cells during gastrulation. May play a role in the migration of embryonic presumptive primordial germ cells (pPGCs). May also be involved in regulating migration of hematopoietic stem cells into the larval liver (By similarity).
messages: Sulfation is required for efficient binding of cxcl12/sdf-1alpha and promotes its dimerization.

8355:pnpla6.L
gene id: 8355:pnpla6.L
uniprot id: A0A1L8F5S9
uniprot id: A0A8J1LFP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108716950
gene id: 8355:LOC108716950
uniprot id: A0A1L8G9N5
names: Similarity
messages: Belongs to the peptidase M10A family.

8355:trub1.L
gene id: 8355:trub1.L
uniprot id: A0A8J1L990
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

8355:mpg.L
gene id: 8355:mpg.L
uniprot id: A0A1L8EXC7
uniprot id: A0A8J1LUI8
uniprot id: A0A8J1LVY2
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

8355:shkbp1.L
gene id: 8355:shkbp1.L
uniprot id: A0A1L8F8Z4
names: Similarity
messages: Belongs to the KCTD3 family.

8355:LOC108702185
gene id: 8355:LOC108702185
uniprot id: A0A1B1FFT6
names: Subcellular Location Annotation
messages: Secreted

8355:agpat4.L
gene id: 8355:agpat4.L
uniprot id: A0A1L8G7Y9
uniprot id: A0A8J1KN17
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

8355:hnf4b.S
gene id: 8355:hnf4b.S
uniprot id: A2VD84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

8355:papss1.S
gene id: 8355:papss1.S
uniprot id: A0A8J1LS24
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

8355:pdcd10.S
gene id: 8355:pdcd10.S
uniprot id: Q8AVR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.

8355:plxdc2.S
gene id: 8355:plxdc2.S
uniprot id: Q6DE92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Membrane

8355:zap70.L
gene id: 8355:zap70.L
uniprot id: Q6DCV6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

8355:pabpn1.S
gene id: 8355:pabpn1.S
uniprot id: Q9DDY9
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Expressed at relatively constant levels throughout development.
messages: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation.
messages: Monomer and homooligomer. Binds RNA as a monomer and oligomerizes when bound to poly(A) (By similarity).
messages: Nucleus
messages: Shows dynamic spatial expression throughout development. First expressed in the animal pole region of the egg and this pattern persists through to the blastula stage. In gastrula and neurula embryos, expressed mainly in ectodermal, neural and epidermal regions. Neural tissue-specific expression pattern persists into tailbud stage when expression is localized to the brain and spinal cord. At early tadpole stage, expression becomes gradually confined to the specific vesicle regions of the developing brain. At stage 39, expressed in the telencephalon and mesencephalon regions of the brain. Also detected in the eye and olfactory pit at the tadpole stage. Expressed during gut endoderm development. At stage 35, expressed exclusively in the anterior portion of the gut endoderm, which includes the prospective liver, stomach and pancreas. As development proceeds, expression becomes restricted to the pancreas, and by stage 46/47 (the seventh day of development) expression is localized exclusively to the pancreas. Expressed in most adult tissues.
messages: The RRM domain is essential for specific adenine bases recognition in the poly(A) tail but not sufficient for poly(A) binding.

8355:palmd.S
gene id: 8355:palmd.S
uniprot id: A0A1L8GG73
names: Similarity
messages: Belongs to the paralemmin family.

8355:cr1b
gene id: 8355:cr1b
uniprot id: Q2UZ97
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.

8355:LOC108702421
gene id: 8355:LOC108702421
uniprot id: A0A1L8EQ57
names: Similarity
messages: Belongs to the globin family.

8355:atp2b4.L
gene id: 8355:atp2b4.L
uniprot id: Q6DCT8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:prxl2a.S
gene id: 8355:prxl2a.S
uniprot id: A0A8J0U4V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

8355:sbk1.S
gene id: 8355:sbk1.S
uniprot id: A0A1L8EQT0
uniprot id: A0A8J1LZJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

8355:comt.S
gene id: 8355:comt.S
uniprot id: Q0IHD3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.

8355:rflna.L
gene id: 8355:rflna.L
uniprot id: Q6GM13
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

8355:catip.L
gene id: 8355:catip.L
uniprot id: Q0IHI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CATIP family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in primary ciliogenesis by modulating actin polymerization.
messages: cytoskeleton

8355:LOC108709193
gene id: 8355:LOC108709193
uniprot id: A0A8J0UB65
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121397722
gene id: 8355:LOC121397722
uniprot id: A0A8J1LQG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8355:sh3bgrl2.S
gene id: 8355:sh3bgrl2.S
uniprot id: Q3KPU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3BGR family.
messages: Nucleus

8355:ipo5.L
gene id: 8355:ipo5.L
uniprot id: A0A8J0U3X2
uniprot id: Q804V4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:LOC108700455
gene id: 8355:LOC108700455
uniprot id: A0A1L8F4T7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8355:krt78.3.S
gene id: 8355:krt78.3.S
uniprot id: A0A1L8HAH3
names: Similarity
messages: Belongs to the intermediate filament family.

8355:hoxa1.L
gene id: 8355:hoxa1.L
uniprot id: Q7ZXI1
names: Subcellular Location Annotation
messages: Nucleus

8355:cenph.L
gene id: 8355:cenph.L
uniprot id: A0A1L8I269
uniprot id: A0A8J0VGU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

8355:ppm1g.L
gene id: 8355:ppm1g.L
uniprot id: A0A1L8GD37
names: Similarity
messages: Belongs to the PP2C family.

8355:LOC108705973
gene id: 8355:LOC108705973
uniprot id: A0A8J0U6I7
names: Subcellular Location Annotation
messages: Membrane

8355:cpe.S
gene id: 8355:cpe.S
uniprot id: B1WBB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Membrane
messages: secretory vesicle membrane

8355:faim2.S
gene id: 8355:faim2.S
uniprot id: Q6GLR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

8355:trappc2l.L
gene id: 8355:trappc2l.L
uniprot id: A0A8J0Q2N9
uniprot id: Q5PQ60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

8355:gabpa.L
gene id: 8355:gabpa.L
uniprot id: Q6DDF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:LOC108702333
gene id: 8355:LOC108702333
uniprot id: A0A8J0TYD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:set.L
gene id: 8355:set.L
uniprot id: A0A8J1LEH3
uniprot id: Q6PGT4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

8355:LOC108705808
gene id: 8355:LOC108705808
uniprot id: A0A8J1LM50
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8355:p4ha1.S
gene id: 8355:p4ha1.S
uniprot id: A0A1L8FF08
uniprot id: A0A8J0TEV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

8355:ccdc172.L
gene id: 8355:ccdc172.L
uniprot id: Q3KPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

8355:napsa.L
gene id: 8355:napsa.L
uniprot id: Q6P7F8
names: Similarity
messages: Belongs to the peptidase A1 family.

8355:orai1.L
gene id: 8355:orai1.L
uniprot id: A0A1L8HDQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

8355:abhd12.S
gene id: 8355:abhd12.S
uniprot id: A0A1L8G1U7
uniprot id: A0A8J1KVM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108707195
gene id: 8355:LOC108707195
uniprot id: A0A8J1M3T0
names: Similarity
messages: Belongs to the glutaredoxin family.

8355:serpina3k.L
gene id: 8355:serpina3k.L
uniprot id: Q66KX6
names: Similarity
messages: Belongs to the serpin family.

8355:madd.L
gene id: 8355:madd.L
uniprot id: A0A1L8GIW3
uniprot id: A0A8J0UUJ7
uniprot id: A0A8J0UUK9
uniprot id: A0A8J0UZ99
uniprot id: A0A8J0UZA4
uniprot id: A0A8J0UZA9
uniprot id: A0A8J0V058
uniprot id: A0A8J0V063
uniprot id: A0A8J0V067
uniprot id: A0A8J0V072
uniprot id: A0A8J0V0F8
uniprot id: A0A8J0V0G9
uniprot id: A0A8J0V480
uniprot id: A0A8J0V485
uniprot id: A0A8J0V490
uniprot id: A0A8J0V496
uniprot id: A0A8J1MV89
uniprot id: A0A8J1MV94
uniprot id: A0A8J1MV99
uniprot id: A0A8J1MVA5
uniprot id: A0A8J1MVB1
uniprot id: A0A8J1MVC0
uniprot id: A0A8J1MVI6
uniprot id: A0A8J1MVJ1
uniprot id: A0A8J1MVJ6
uniprot id: A0A8J1MVK0
uniprot id: A0A8J1MVK6
uniprot id: A0A8J1MVL4
uniprot id: A0A8J1MVL9
uniprot id: A0A8J1MWE4
uniprot id: A0A8J1MWE9
uniprot id: A0A8J1MWF4
uniprot id: A0A8J1MWF9
uniprot id: A0A8J1MWG4
uniprot id: A0A8J1MWH2
uniprot id: A0A8J1MWH6
uniprot id: A0A8J1MWT8
uniprot id: A0A8J1MWU4
uniprot id: A0A8J1MWV1
uniprot id: A0A8J1MWV9
uniprot id: A0A8J1MWW8
uniprot id: A0A8J1MWX3
uniprot id: A0A8J1MWX9
uniprot id: A0A8J1MXQ1
uniprot id: A0A8J1MXQ7
uniprot id: A0A8J1MXR2
uniprot id: A0A8J1MXR8
uniprot id: A0A8J1MXS3
uniprot id: A0A8J1MXT3
uniprot id: A0A8J1MXT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8355:pln.L
gene id: 8355:pln.L
uniprot id: A0A1L8G8X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

8355:tomm7.L
gene id: 8355:tomm7.L
uniprot id: A0A8J0VIX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

8355:mis12.L
gene id: 8355:mis12.L
uniprot id: A0A1L8HGC4
uniprot id: A0A8J1M5E8
uniprot id: A0A8J1M6I0
uniprot id: Q6GNY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

8355:alox15b.L
gene id: 8355:alox15b.L
uniprot id: A0A1L8HJQ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:lrrc8e.L
gene id: 8355:lrrc8e.L
uniprot id: A0A1L8H2K9
uniprot id: Q6NU09
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Heterohexamer. Oligomerizes with other LRRC8 proteins (lrrc8a, lrrc8c, lrrc8d and/or lrrc8b) to form a heterohexamer. Detected in a channel complex that contains lrrc8a, lrrc8c and lrrc8e. In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist.
messages: Lysosome membrane
messages: Membrane
messages: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires lrrc8a plus at least one other family member (lrrc8b, lrrc8c, lrrc8d or lrrc8e); channel characteristics depend on the precise subunit composition. Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis.
messages: The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins.

8355:c8orf33.L
gene id: 8355:c8orf33.L
uniprot id: A0A8J0TNR5
uniprot id: A0A8J0TVV1
uniprot id: A0A8J0TW71
uniprot id: A0A8J0TYU6
names: Similarity
messages: Belongs to the UPF0488 family.

8355:cdh13.S
gene id: 8355:cdh13.S
uniprot id: A0A8J0V6B9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

8355:LOC121402250
gene id: 8355:LOC121402250
uniprot id: A0A1L8G0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:emc4.L
gene id: 8355:emc4.L
uniprot id: Q6GR43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

8355:XB5950266.L
gene id: 8355:XB5950266.L
uniprot id: A0A1L8GAR7
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
messages: Homotetramer.

8355:slc39a7.L
gene id: 8355:slc39a7.L
uniprot id: A0A1L8F8F2
uniprot id: Q08AZ8
names: Subcellular Location Annotation
messages: Membrane

8355:spdl1.L
gene id: 8355:spdl1.L
uniprot id: Q5BIX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spindly family.
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.
messages: kinetochore

8355:LOC108700881
gene id: 8355:LOC108700881
uniprot id: A0A1L8ESK4
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

8355:parp1.L
gene id: 8355:parp1.L
uniprot id: Q2NLA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.

8355:vgll4.L
gene id: 8355:vgll4.L
uniprot id: A0A8J0U4D7
uniprot id: A0A8J0U6D6
uniprot id: Q0IH83
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

8355:per3.S
gene id: 8355:per3.S
uniprot id: A0A1L8FGK4
uniprot id: A0A8J0TGG1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:LOC108710067
gene id: 8355:LOC108710067
uniprot id: A0A1L8HBF0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

8355:mtmr7.L
gene id: 8355:mtmr7.L
uniprot id: A0A1L8HTU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

8355:slc4a9.L
gene id: 8355:slc4a9.L
uniprot id: A0A1L8GXA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

8355:usp13.L
gene id: 8355:usp13.L
uniprot id: A0A1L8GA59
uniprot id: A0A8J0VBQ6
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:LOC108702401
gene id: 8355:LOC108702401
uniprot id: A0A8J1LZ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:spata6l.L
gene id: 8355:spata6l.L
uniprot id: A0A1L8HY23
uniprot id: A0A8J0UMP8
uniprot id: A0A8J1MCV3
uniprot id: Q3KPY8
names: Similarity
messages: Belongs to the SPATA6 family.

8355:gamt.S
gene id: 8355:gamt.S
uniprot id: Q7ZXG7
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Monomer.

8355:sgpl1.L
gene id: 8355:sgpl1.L
uniprot id: A0A1L8FK37
names: Similarity
messages: Belongs to the group II decarboxylase family.

8355:crygdl.25.L
gene id: 8355:crygdl.25.L
uniprot id: A0A1L8HX04
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:LOC108714027
gene id: 8355:LOC108714027
uniprot id: A0A1L8GKP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8355:ppp6c.S
gene id: 8355:ppp6c.S
uniprot id: Q52L13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

8355:sgsh.L
gene id: 8355:sgsh.L
uniprot id: A0A8J0TVS8
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

8355:slc35d1.L
gene id: 8355:slc35d1.L
uniprot id: A0A1L8GLT7
names: Subcellular Location Annotation
messages: Membrane

8355:bcl2l14.S
gene id: 8355:bcl2l14.S
uniprot id: Q6AX16
names: Similarity
messages: Belongs to the Bcl-2 family.

8355:tle4.S
gene id: 8355:tle4.S
uniprot id: A0A1L8HP89
uniprot id: A0A8J0TV50
uniprot id: A0A8J1M4W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

8355:acad8.L
gene id: 8355:acad8.L
uniprot id: A0A8J0SYX9
uniprot id: Q6PGS8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

8355:LOC108696974
gene id: 8355:LOC108696974
uniprot id: A0A8J1L8Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

8355:cers2.S
gene id: 8355:cers2.S
uniprot id: A0A1L8F4H2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

8355:epb41.L
gene id: 8355:epb41.L
uniprot id: A0A8J1M549
uniprot id: A0A8J1M551
uniprot id: A0A8J1M554
uniprot id: A0A8J1M556
uniprot id: A0A8J1M558
uniprot id: A0A8J1M560
uniprot id: A0A8J1M561
uniprot id: A0A8J1M563
uniprot id: A0A8J1M568
uniprot id: A0A8J1M680
uniprot id: A0A8J1M687
uniprot id: A0A8J1M692
uniprot id: A0A8J1M697
uniprot id: A0A8J1M6Z4
uniprot id: A0A8J1M702
uniprot id: A0A8J1M707
uniprot id: P11434
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin.
messages: Found exclusively in photoreceptors following the terminal mitosis of retinal neurons. When retinal synaptogenesis is complete, protein 4.1 is also expressed in the inner retina. In adult amphibian retinas, protein 4.1 is detected in photoreceptors, bipolar cells, and ganglion cell axons.
messages: Nucleus
messages: Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
messages: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. May be required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
messages: cell cortex
messages: cytoskeleton

8355:mrps24.S
gene id: 8355:mrps24.S
uniprot id: Q6NTS3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

8355:slc17a9.L
gene id: 8355:slc17a9.L
uniprot id: A0A1L8ET56
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108719791
gene id: 8355:LOC108719791
uniprot id: A0A8J1L0Z8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:adora2a.L
gene id: 8355:adora2a.L
uniprot id: Q5XGP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

8355:MGC85221
gene id: 8355:MGC85221
uniprot id: A0A8J0TIH6
uniprot id: Q66L30
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

8355:sart3.L
gene id: 8355:sart3.L
uniprot id: A0A1L8HZW2
names: Subcellular Location Annotation
messages: nucleoplasm

8355:LOC108709733
gene id: 8355:LOC108709733
uniprot id: A0A1L8H8Z3
uniprot id: A0A8J0UL69
uniprot id: A0A8J0UP24
uniprot id: A0A8J1MF53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

8355:chmp4b.S
gene id: 8355:chmp4b.S
uniprot id: A0A1L8EMW7
names: Similarity
messages: Belongs to the SNF7 family.

8355:mrpl27.L
gene id: 8355:mrpl27.L
uniprot id: A0A8J0TTX1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

8355:itga6.L
gene id: 8355:itga6.L
uniprot id: A0A1L8EW82
uniprot id: A0A8J0TUM4
uniprot id: A0A8J0TV43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8355:tmem50b.S
gene id: 8355:tmem50b.S
uniprot id: A0A1L8H596
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

8355:fez2.S
gene id: 8355:fez2.S
uniprot id: A0A1L8G205
uniprot id: A0A8J0VBY1
names: Similarity
messages: Belongs to the zygin family.

8355:LOC108710260
gene id: 8355:LOC108710260
uniprot id: A0A8J1MMQ3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:dlgap1.S
gene id: 8355:dlgap1.S
uniprot id: A0A1L8FST2
uniprot id: A0A8J0VL95
uniprot id: A0A8J1L2K3
names: Similarity
messages: Belongs to the SAPAP family.

8355:dcaf13.S
gene id: 8355:dcaf13.S
uniprot id: A0A1L8FTR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

8355:manf.L
gene id: 8355:manf.L
uniprot id: A0A1L8GPG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

8355:tpp1.L
gene id: 8355:tpp1.L
uniprot id: Q6NTQ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:psmb4.L
gene id: 8355:psmb4.L
uniprot id: Q7T0M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

8355:LOC121397546
gene id: 8355:LOC121397546
uniprot id: A0A8J1LLC0
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

8355:dcaf10.S
gene id: 8355:dcaf10.S
uniprot id: A0A8J0U2H1
uniprot id: A0A8J0U3S0
names: Function
names: Similarity
messages: Belongs to the WD repeat DCAF10 family.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

8355:krt19.L
gene id: 8355:krt19.L
uniprot id: A0A8J0TRW3
uniprot id: Q6IRP5
names: Similarity
messages: Belongs to the intermediate filament family.

8355:mrpl30.S
gene id: 8355:mrpl30.S
uniprot id: A0A1L8H8R4
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

8355:sema3c.L
gene id: 8355:sema3c.L
uniprot id: A0A1L8GZB7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:supt16h.L
gene id: 8355:supt16h.L
uniprot id: A0A1L8HZH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

8355:selenok.L
gene id: 8355:selenok.L
uniprot id: A0A8J0QHK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein K family.
messages: Endoplasmic reticulum membrane

8355:shc1.S
gene id: 8355:shc1.S
uniprot id: A0A1L8F596
uniprot id: A0A8J0TI72
uniprot id: A0A8J0TQW6
uniprot id: A0A8J1LLU9
uniprot id: A0A8J1LM06
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC101027275
gene id: 8355:LOC101027275
uniprot id: G3CH39
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

8355:ubtf.L
gene id: 8355:ubtf.L
uniprot id: P25979
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus
messages: UBF recognizes the ribosomal RNA gene promotor and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element.
messages: XUBF consists of 2 polypeptides of 82 and 85 kDa, encoded by the same or closely related genes.

8355:cflar.S
gene id: 8355:cflar.S
uniprot id: A0A8J0TTF5
uniprot id: A0A8J0U0X7
uniprot id: A0A8J0U3U0
names: Similarity
messages: Belongs to the peptidase C14A family.

8355:chpt1.L
gene id: 8355:chpt1.L
uniprot id: A0A8J0UMR5
uniprot id: Q4KLV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
messages: Golgi apparatus membrane

8355:nit1.S
gene id: 8355:nit1.S
uniprot id: A0A1L8F521
uniprot id: A0A8J1LMW9
uniprot id: Q66KS6
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

8355:scnn1b.L
gene id: 8355:scnn1b.L
uniprot id: Q6DE38
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Membrane
messages: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.

8355:LOC121393159
gene id: 8355:LOC121393159
uniprot id: A0A8J1KKL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:LOC121394165
gene id: 8355:LOC121394165
uniprot id: A0A1L8G1J1
uniprot id: A0A8J1KSD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:tmpo.L
gene id: 8355:tmpo.L
uniprot id: A0A1L8GY70
uniprot id: A0A8J0QGJ6
uniprot id: A0A8J1MGL8
uniprot id: A0A8J1MH59
uniprot id: A0A8J1MIH3
uniprot id: O73766
uniprot id: Q4LDN2
names: Similarity
messages: Belongs to the LEM family.

8355:cnn1.S
gene id: 8355:cnn1.S
uniprot id: Q6PAB2
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

8355:med19.L
gene id: 8355:med19.L
uniprot id: Q5EAY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

8355:LOC108710482
gene id: 8355:LOC108710482
uniprot id: A0A8J0USE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fam118b.S
gene id: 8355:fam118b.S
uniprot id: A0A1L8FG15
uniprot id: A0A8J0TEK1
uniprot id: A0A8J0TFD3
uniprot id: A0A8J1LCS2
uniprot id: A0A8J1LE51
uniprot id: A0A8J1LE56
uniprot id: A0A8J1LF34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

8355:dgka.L
gene id: 8355:dgka.L
uniprot id: A0A8J0U8D1
uniprot id: A0A8J0UJ73
uniprot id: A0A8J1M9S1
uniprot id: A0A8J1MAR9
uniprot id: A0A8J1MBJ5
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8355:prkdc.L
gene id: 8355:prkdc.L
uniprot id: Q9DEI1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated at two clusters, the T2609 cluster and the S2056 cluster. Autophosphorylated on Ser-2075, Thr-2631, Thr-2659 and Thr-2668. Ser-2075 and Thr-2668 are DNA damage-inducible phosphorylation sites (inducible with ionizing radiation, IR) dephosphorylated by PPP5C (By similarity). Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair (By similarity). Autophosphorylation in trans within DNA-PK complexes loaded on DNA ends leads to the dissociation of PRKDC from DNA and the transition into the short-range NHEJ complex (By similarity). Autophosphorylation of the T2609 cluster is required for hematopoietic development and protein synthesis in erythrocytes precursors (By similarity).
messages: Belongs to the PI3/PI4-kinase family.
messages: DNA-PK is a heterotrimer of prkdc and the Ku dimer (composed of xrcc6/Ku70 and xrcc5/Ku86). Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of prkdc, lig4, xrcc4, xrcc6/ku70, xrcc5/ku86 and nhej1/xlf. Additional component of the NHEJ complex includes paxx. Following autophosphorylation, prkdc dissociates from DNA.
messages: Nucleus
messages: Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ. Act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (By similarity). Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (By similarity).
messages: nucleolus

8355:ezh1.S
gene id: 8355:ezh1.S
uniprot id: A0A1L8EMG9
uniprot id: A0A8J1M021
names: Subcellular Location Annotation
messages: Nucleus

8355:tbx18.L
gene id: 8355:tbx18.L
uniprot id: G9B8Q3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:slc27a2.S
gene id: 8355:slc27a2.S
uniprot id: A0A1L8GSZ1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:corin.L
gene id: 8355:corin.L
uniprot id: A0A1L8HTN5
uniprot id: A0A8J0TJM4
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC121393511
gene id: 8355:LOC121393511
uniprot id: A0A8J1KPH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:proca1.L
gene id: 8355:proca1.L
uniprot id: A0A8J0UBH0
names: Subcellular Location Annotation
messages: Secreted

8355:sec24b.L
gene id: 8355:sec24b.L
uniprot id: A0A1L8HUR0
uniprot id: A0A8J1MYD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8355:pou4f4.L
gene id: 8355:pou4f4.L
uniprot id: A0A1L8F7T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

8355:foxa2.L
gene id: 8355:foxa2.L
uniprot id: Q91765
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcriptional activator during early development, limiting the extent of mesoderm formation in the gastrula. Binds to DNA via the target sequence 5'-GT[AC]AACA-3', with 5'-GTAAACA-3' being the preferred binding site.
messages: At gastrula stage, expressed in both the anterior and posterior endoderm, with endodermal expression persisting into early tailbud stages. Expression is absent in gastrula stage ectoderm. During tailbud stages, expressed in the pharyngeal region, the neural floor plate, the midbrain, hindbrain and in cranial neural crest cells. Expressed in the foregut of hatching larvae. In tadpoles, expressed in the pharyngeal pouches and in other anterior endodermal regions. Within the tadpole nervous system, expressed in the neural floor plate, at high levels in the ventral midbrain and hindbrain, and at lower levels in the spinal cord. Expressed in the adult lung and brain.
messages: First detected in early gastrula stage embryos. Abundant at the neurula stage, becoming less abundant at later stages.
messages: Nucleus

8355:LOC108719297
gene id: 8355:LOC108719297
uniprot id: A0A1L8FZ93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

8355:inip.S
gene id: 8355:inip.S
uniprot id: A0A8J1LIY2
uniprot id: Q8AVV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Belongs to the multiprotein complex Integrator. Component of the SOSS complex, composed of soss-b (soss-b1/nabp2 or soss-b2/nabp1), soss-a/ints3 and soss-c/inip (By similarity).
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity).
messages: Nucleus

8355:sfmbt2.S
gene id: 8355:sfmbt2.S
uniprot id: A0A1L8GTN0
uniprot id: A0A8J0UX60
names: Subcellular Location Annotation
messages: Nucleus

8355:bzw1.L
gene id: 8355:bzw1.L
uniprot id: Q8AVM7
names: Function
names: Similarity
messages: Belongs to the BZW family.
messages: Translation initiation regulator which may repress repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity).

8355:cbwd2.L
gene id: 8355:cbwd2.L
uniprot id: A0A8J1M5I7
uniprot id: Q6DD59
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

8355:zc3h15.L
gene id: 8355:zc3h15.L
uniprot id: Q6DD06
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ZC3H15/TMA46 family.
messages: Cytoplasm
messages: Interacts with drg1.
messages: Nucleus
messages: Protects drg1 from proteolytic degradation.
messages: Strongly expressed in ovary. Moderately expressed in brain, kidney, spleen, testis, intestine and colon.
messages: Weakly expressed in late gastrula. Strongly expressed from late neurula (stages 20-22) to tadpole (stages 40-41). At stage 22, expressed in blood islands, somites, eyes, trunk neural crest, mandibular crest segment, hyoid crest segment and branchial crest segment. At stage 32, expressed in otic vesicle, pronephros, forebraiin, midbrain, hindbrain, branchial arch, eyes, lens, spinal cord and notochord.

8355:hrh4.g1.L
gene id: 8355:hrh4.g1.L
uniprot id: A0A1L8FYT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:oxct1.L
gene id: 8355:oxct1.L
uniprot id: Q6PCE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

8355:cds1.L
gene id: 8355:cds1.L
uniprot id: A0A1L8HVX0
uniprot id: A0A8J1MZQ1
uniprot id: A0A8J1N253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

8355:LOC108710830
gene id: 8355:LOC108710830
uniprot id: A0A1L8GWS1
uniprot id: A0A8J0UQ37
uniprot id: A0A8J0UT64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Nucleus

8355:copb1.S
gene id: 8355:copb1.S
uniprot id: Q498K6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8355:nsun6.L
gene id: 8355:nsun6.L
uniprot id: A0A8J1KW45
uniprot id: A0A8J1KW48
uniprot id: A0A8J1KXR8
uniprot id: A0A8J1KZ44
uniprot id: Q0IHJ9
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:actc1.L
gene id: 8355:actc1.L
uniprot id: P04751
names: Developmental Stage
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Actins are highly conserved proteins that are involved in various types of cell motility.
messages: Belongs to the actin family.
messages: Expressed from the end of gastrulation.
messages: Methylated at His-75 by SETD3.
messages: Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
messages: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
messages: Shows overlapping but distinct expression patterns with other actins. In tailbud embryos, expressed in embryonic muscle (myotomes). In adults, expressed only in heart muscle.
messages: The cardiac versus skeletal expression patterns of actins are probably sequence-dependent. For example, cardiac actins contain a Glu at position 3 of the mature peptide, whereas skeletal actins contain an Asp at this position.
messages: Xenopus contains at least three sarcomeric alpha actin genes that are preferentially expressed in either heart or skeletal muscle. Due to the tetraploid nature of Xenopus laevis, each of these three alpha actin genes is present in at least two copies.
messages: cytoskeleton

8355:kcnk2.S
gene id: 8355:kcnk2.S
uniprot id: A0A8J0VK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:itgb8.S
gene id: 8355:itgb8.S
uniprot id: A0A8J1L1M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

8355:snx33.L
gene id: 8355:snx33.L
uniprot id: A0A1L8H025
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

8355:tp53i11.S
gene id: 8355:tp53i11.S
uniprot id: Q52KW4
names: Subcellular Location Annotation
messages: Membrane

8355:bco1.L
gene id: 8355:bco1.L
uniprot id: A0A1L8GKQ4
uniprot id: A0A8J1MW44
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

8355:LOC108706899
gene id: 8355:LOC108706899
uniprot id: A0A1L8HNN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8355:LOC108698872
gene id: 8355:LOC108698872
uniprot id: A0A8J1LGD4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:dpp4.S
gene id: 8355:dpp4.S
uniprot id: P70092
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

8355:apoo.L
gene id: 8355:apoo.L
uniprot id: Q6NUG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

8355:srsf5a.S
gene id: 8355:srsf5a.S
uniprot id: A0A1L8EZK9
uniprot id: A0A8J1LNN5
uniprot id: A0A8J1LPP3
names: Similarity
messages: Belongs to the splicing factor SR family.

8355:LOC108704440
gene id: 8355:LOC108704440
uniprot id: A0A8J1LM90
uniprot id: A0A8J1LMG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

8355:polb.S
gene id: 8355:polb.S
uniprot id: A0A8J0UU72
uniprot id: O57383
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-X family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.
messages: Monomer.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity).
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
messages: Ubiquitinated: monoubiquitinated by huwe1/arf-bp1. Monoubiquitinated protein is then the target of stub1/chip, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. usp47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation (By similarity).

8355:LOC108718024
gene id: 8355:LOC108718024
uniprot id: A0A8J1KTM9
uniprot id: A0A8J1KTN6
uniprot id: A0A8J1KWN7
names: Similarity
messages: Belongs to the SAPAP family.

8355:snrpf.S
gene id: 8355:snrpf.S
uniprot id: P62321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg, and at least three U1 snRNP-specific proteins snrnp70/u1-70k, snrpa/u1-a and snrpc/u1-c. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least prpf3, prpf4, prpf6, prpf8, prpf31, snrnp200, txnl4a, snrnp40, snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf, snrpg, ddx23, cd2bp2, ppih, snu13, eftud2, sart1 and usp39, plus lsm2, lsm3, lsm4, lsm5, lsm6, lsm7 and lsm8. Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least lsm10, lsm11, snrpb, snrpd3, snrpe, snrpf and snrpg; the complex does not contain snrpd1 and snrpd2. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains smn1, gemin2/sip1, ddx20/gemin3, gemin4, gemin5, gemin6, gemin7, gemin8, strap/unrip and the Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of clns1a/pICln, snrpd1, snrpd2, snrpe, snrpf and snrpg; ring-like structure where clns1a/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

8355:LOC108719598
gene id: 8355:LOC108719598
uniprot id: A0A8J0VPS3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:erlin2.L
gene id: 8355:erlin2.L
uniprot id: A0A8J1MHC6
uniprot id: A0A8J1MJA5
uniprot id: Q5XH03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Promotes sterol-accelerated ERAD of HMGCR. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (By similarity).
messages: Membrane

8355:tsc22d3.S
gene id: 8355:tsc22d3.S
uniprot id: Q63ZK9
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

8355:fam50a.L
gene id: 8355:fam50a.L
uniprot id: Q2VPH1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probably involved in the regulation of pre-mRNA splicing.

8355:srd5a3.S
gene id: 8355:srd5a3.S
uniprot id: A0A8J0TP12
uniprot id: Q8AVI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).

8355:crygdl.4.L
gene id: 8355:crygdl.4.L
uniprot id: A0A8J0TCU3
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:slc22a15.2.S
gene id: 8355:slc22a15.2.S
uniprot id: Q7ZX53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Membrane
messages: Probably transports organic cations.

8355:LOC108696412
gene id: 8355:LOC108696412
uniprot id: A0A8J1L6H1
uniprot id: A0A8J1L865
uniprot id: A0A8J1L958
names: Similarity
messages: Belongs to the NXPE family.

8355:LOC108695852
gene id: 8355:LOC108695852
uniprot id: A0A1L8FME8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:crybg3.S
gene id: 8355:crybg3.S
uniprot id: A0A1L8H549
uniprot id: A0A8J0UJB9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:mcl1.S
gene id: 8355:mcl1.S
uniprot id: A0A1L8F4J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: nucleoplasm

8355:terf1.L
gene id: 8355:terf1.L
uniprot id: Q71E47
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus

8355:chrm4.S
gene id: 8355:chrm4.S
uniprot id: A0A1L8GDU2
uniprot id: A0A8J0VA52
uniprot id: A0A8J1KJI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

8355:paqr9.L
gene id: 8355:paqr9.L
uniprot id: A0A1L8GAG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8355:esrrg.S
gene id: 8355:esrrg.S
uniprot id: A0A1L8G135
uniprot id: A0A8J0VBJ1
uniprot id: A0A8J0VEQ3
uniprot id: A0A8J0VK33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8355:arl11l.1.L
gene id: 8355:arl11l.1.L
uniprot id: A0A1L8HIC6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8355:LOC108700478
gene id: 8355:LOC108700478
uniprot id: A0A8J1LM79
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

8355:LOC108695971
gene id: 8355:LOC108695971
uniprot id: A0A1L8FPU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

8355:rap1b.L
gene id: 8355:rap1b.L
uniprot id: Q7ZXH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell junction
messages: Cell membrane
messages: Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity).
messages: cytosol

8355:LOC121398920
gene id: 8355:LOC121398920
uniprot id: A0A8J1M0B2
names: Similarity
messages: Belongs to the cyclin family.

8355:tm4sf1.S
gene id: 8355:tm4sf1.S
uniprot id: Q66KQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8355:cibar1.S
gene id: 8355:cibar1.S
uniprot id: Q2VR06
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Plays a role in ciliogenesis (By similarity). Plays an important role in the mitochondrial function and is essential for maintaining mitochondrial morphology and inner membrane ultrastructure (By similarity).
messages: Belongs to the CIBAR family.
messages: Cytoplasm
messages: Mitochondrion inner membrane
messages: Nucleus
messages: The BAR-like domain displays limited similarity to other BAR domains.
messages: centriole

8355:spc24.L
gene id: 8355:spc24.L
uniprot id: Q6NRW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity).
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex, which is composed of ndc80, cdca1, spbc24 and spbc25. The NDC80 complex interacts with mis12 and zwint.
messages: Nucleus
messages: kinetochore

8355:pkn1.L
gene id: 8355:pkn1.L
uniprot id: A0A1L8H2L2
uniprot id: A0A8J0UTG4
uniprot id: A0A8J1MNW1
uniprot id: A0A8J1MNY0
uniprot id: A0A8J1MQ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

8355:itga7.S
gene id: 8355:itga7.S
uniprot id: A0A1L8H9L0
uniprot id: A0A8J1MF25
uniprot id: A0A8J1MG08
uniprot id: A0A8J1MGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

8355:mep1b.S
gene id: 8355:mep1b.S
uniprot id: A0A1L8FSY5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:ppia.L
gene id: 8355:ppia.L
uniprot id: Q6DTN6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

8355:thra.L
gene id: 8355:thra.L
uniprot id: A0A8J0TQR7
uniprot id: P15204
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A number of compounds can compete with and disrupt triiodothyronine (T3)-binding including 3,3',5-triiodothyroacetic acid.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Binds to thyroid hormone receptor element (TRE) weakly as homodimers and monomers, but binds TRE with much higher affinity as heterodimers with retinoid X receptors. Can bind DNA as a heterodimer with either rxra or rxrg.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Expression peaks at the climax of metamorphosis.
messages: High affinity receptor for triiodothyronine (T3).
messages: Nucleus

8355:grm3.S
gene id: 8355:grm3.S
uniprot id: A0A1L8GTT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

8355:mypop.L
gene id: 8355:mypop.L
uniprot id: Q08B72
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Contaminating sequence. Potential poly-A sequence.
messages: Nucleus
messages: Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'.

8355:LOC108711090
gene id: 8355:LOC108711090
uniprot id: A0A1L8HVC3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

8355:nme2.L
gene id: 8355:nme2.L
uniprot id: P70010
uniprot id: P70071
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

8355:chrnb1.L
gene id: 8355:chrnb1.L
uniprot id: A0A1L8H4F7
uniprot id: A0A8J1MPJ3
uniprot id: A0A8J1MQM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:LOC121401134
gene id: 8355:LOC121401134
uniprot id: A0A8J1MI61
names: Similarity
messages: Belongs to the TMEM121 family.

8355:foxn2.L
gene id: 8355:foxn2.L
uniprot id: A0A1L8G685
names: Subcellular Location Annotation
messages: Nucleus

8355:pkib.L
gene id: 8355:pkib.L
uniprot id: A0A1L8G8I6
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

8355:atf7ip.L
gene id: 8355:atf7ip.L
uniprot id: A0A1L8GNC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

8355:mis18a.S
gene id: 8355:mis18a.S
uniprot id: A0A1L8H569
uniprot id: A0A8J1MCA2
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

8355:gusb.L
gene id: 8355:gusb.L
uniprot id: A0A1L8HG66
uniprot id: A0A8J0UFP4
uniprot id: A0A8J0UI52
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

8355:gsx1.S
gene id: 8355:gsx1.S
uniprot id: A0A1L8HAL1
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108711733
gene id: 8355:LOC108711733
uniprot id: A0A8J1MQC5
names: Subcellular Location Annotation
messages: Secreted

8355:LOC108712645
gene id: 8355:LOC108712645
uniprot id: A0A8J1MQA5
uniprot id: A0A8J1MSI1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

8355:LOC108710508
gene id: 8355:LOC108710508
uniprot id: A0A8J0UPE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108698509
gene id: 8355:LOC108698509
uniprot id: A0A8J1LJT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108706782
gene id: 8355:LOC108706782
uniprot id: A0A1L8HML2
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108709642
gene id: 8355:LOC108709642
uniprot id: A0A1L8H8E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

8355:LOC108715742
gene id: 8355:LOC108715742
uniprot id: A0A1L8GGU8
uniprot id: A0A8J0V7J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8355:trabd2b.L
gene id: 8355:trabd2b.L
uniprot id: A0A8J0UWY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

8355:fgfr2.S
gene id: 8355:fgfr2.S
uniprot id: A0A1L8FE89
uniprot id: A0A8J0TEF2
uniprot id: A0A8J0TF22
uniprot id: A0A8J1LCX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:brd1.L
gene id: 8355:brd1.L
uniprot id: A0A1L8GZ27
uniprot id: A0A8J0URG1
uniprot id: A0A8J1MIY8
uniprot id: Q6GNT1
names: Subcellular Location Annotation
messages: Nucleus

8355:mfn1.L
gene id: 8355:mfn1.L
uniprot id: A0A1L8G9Z8
uniprot id: Q6GQ50
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

8355:MGC52899
gene id: 8355:MGC52899
uniprot id: Q801R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

8355:emc2.S
gene id: 8355:emc2.S
uniprot id: Q8AVU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

8355:fgf23.2.L
gene id: 8355:fgf23.2.L
uniprot id: A0A8J0UGD4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:LOC121401463
gene id: 8355:LOC121401463
uniprot id: A0A8J1ML15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:ndufb6.L
gene id: 8355:ndufb6.L
uniprot id: A0A1L8HXS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8355:dnah12.L
gene id: 8355:dnah12.L
uniprot id: A0A8J0TVW2
names: Similarity
messages: Belongs to the dynein heavy chain family.

8355:LOC108702440
gene id: 8355:LOC108702440
uniprot id: A0A8J0TYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:nos1.L
gene id: 8355:nos1.L
uniprot id: A0A1L8I1A8
uniprot id: A0A8J1MNE2
uniprot id: B7ZRI9
uniprot id: Q800E5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.
messages: dendritic spine
messages: sarcolemma

8355:mrpl51.L
gene id: 8355:mrpl51.L
uniprot id: A0A1L8FJ49
uniprot id: A0A8J0T0M4
uniprot id: A0A8J1L4V3
uniprot id: Q66KZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).
messages: Mitochondrion

8355:tspan1.L
gene id: 8355:tspan1.L
uniprot id: Q5HZS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:xrcc6.L
gene id: 8355:xrcc6.L
uniprot id: Q6AZR6
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108701294
gene id: 8355:LOC108701294
uniprot id: A0A8J0TVV6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108702175
gene id: 8355:LOC108702175
uniprot id: A0A8J0TY58
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:glra1.S
gene id: 8355:glra1.S
uniprot id: A0A1L8GR09
uniprot id: A0A8J1MQB8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

8355:efemp2.L
gene id: 8355:efemp2.L
uniprot id: A0A1L8GJV8
uniprot id: A0A8J0V4U7
uniprot id: A0A8J1MVQ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:kcnk15.L
gene id: 8355:kcnk15.L
uniprot id: A0A1L8ES36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:LOC121401348
gene id: 8355:LOC121401348
uniprot id: A0A8J0PX99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:smim12.S
gene id: 8355:smim12.S
uniprot id: A1L2P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM12 family.
messages: Membrane

8355:sord.L
gene id: 8355:sord.L
uniprot id: Q6DJH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Mitochondrion membrane
messages: flagellum

8355:kcns3.L
gene id: 8355:kcns3.L
uniprot id: A0A1L8GBL3
names: Subcellular Location Annotation
messages: Membrane

8355:amh.S
gene id: 8355:amh.S
uniprot id: A0A1L8HNG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

8355:anks1a.S
gene id: 8355:anks1a.S
uniprot id: A0A1L8H6M2
uniprot id: A0A8J0UA42
uniprot id: A0A8J0UGT1
uniprot id: A0A8J0UI46
uniprot id: A0A8J0UIA5
uniprot id: Q6IRM7
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108706377
gene id: 8355:LOC108706377
uniprot id: A0A8J0TZH9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:grtp1.S
gene id: 8355:grtp1.S
uniprot id: Q6GLZ0
names: Function
messages: May act as a GTPase-activating protein for Rab family protein(s).

8355:cel.2.L
gene id: 8355:cel.2.L
uniprot id: Q7SYX7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8355:LOC121394781
gene id: 8355:LOC121394781
uniprot id: A0A1L8FUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

8355:hmgxb4.S
gene id: 8355:hmgxb4.S
uniprot id: Q6WKW9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed both maternally and zygotically. Widely expressed at the early gastrula stage. Expressed throughout early embryogenesis until at least the tadpole stage.
messages: Interacts with nlk.2.
messages: Negatively regulates Wnt/beta-catenin signaling during development.
messages: Nucleus

8355:rabep2.L
gene id: 8355:rabep2.L
uniprot id: A0A8J0TXJ0
names: Subcellular Location Annotation
messages: centrosome
messages: cilium basal body

8355:bche.L
gene id: 8355:bche.L
uniprot id: A0A1L8GAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

8355:psmb8.L
gene id: 8355:psmb8.L
uniprot id: Q91787
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:cacnb1.S
gene id: 8355:cacnb1.S
uniprot id: A0A8J0TYR1
uniprot id: A0A8J1M027
uniprot id: A0A8J1M054
uniprot id: A0A8J1M086
uniprot id: A0A8J1M1A2
names: Subcellular Location Annotation
messages: Membrane
messages: sarcolemma

8355:LOC108698201
gene id: 8355:LOC108698201
uniprot id: A0A1L8F654
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8355:purg.S
gene id: 8355:purg.S
uniprot id: A0A8J1M287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

8355:tyrobp.L
gene id: 8355:tyrobp.L
uniprot id: A0A8J0TC89
uniprot id: A0A8J0TCU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

8355:hmg20a.L
gene id: 8355:hmg20a.L
uniprot id: Q6AZF8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in neuronal differentiation.

8355:st7.L
gene id: 8355:st7.L
uniprot id: A0A8J0UMD1
uniprot id: A0A8J0UNL2
uniprot id: Q6DDN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

8355:eps8l2.L
gene id: 8355:eps8l2.L
uniprot id: A0A1L8GJJ0
names: Similarity
messages: Belongs to the EPS8 family.

8355:rps11.L
gene id: 8355:rps11.L
uniprot id: Q7SZ77
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

8355:sbno1.S
gene id: 8355:sbno1.S
uniprot id: A0A1L8HQM1
uniprot id: A0A8J0TZ96
uniprot id: A0A8J0U6F5
uniprot id: A0A8J0U7M5
uniprot id: A0A8J0U7N1
uniprot id: A0A8J0U7N7
names: Similarity
messages: Belongs to the SBNO family.

8355:uchl1.S
gene id: 8355:uchl1.S
uniprot id: Q3B8B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:rgs4.L
gene id: 8355:rgs4.L
uniprot id: A0A1L8GN43
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

8355:emp3.L
gene id: 8355:emp3.L
uniprot id: Q7ZWU6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108716545
gene id: 8355:LOC108716545
uniprot id: A0A8J0VFB4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:ubxn1.L
gene id: 8355:ubxn1.L
uniprot id: Q6GLV4
names: Function
names: Subcellular Location Annotation
messages: Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity).
messages: Cytoplasm

8355:mafb.L
gene id: 8355:mafb.L
uniprot id: A0A1L8ETY4
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

8355:LOC108703865
gene id: 8355:LOC108703865
uniprot id: A0A8J0TVK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8355:LOC108710334
gene id: 8355:LOC108710334
uniprot id: A0A8J1MMN0
uniprot id: A0A8J1MPQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

8355:cfap97d1.S
gene id: 8355:cfap97d1.S
uniprot id: A0A1L8H8V5
names: Similarity
messages: Belongs to the CFAP97 family.

8355:slc10a7.S
gene id: 8355:slc10a7.S
uniprot id: A0A8J0TQ60
uniprot id: Q7T0V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates.
messages: Strongly expressed in small intestine. Moderately expressed in spleen. Weakly expressed in skeletal muscle. Not detected in other tissues tested.

8355:LOC108716514
gene id: 8355:LOC108716514
uniprot id: A0A8J0V9N9
uniprot id: A0A8J0VB05
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:fgf3.L
gene id: 8355:fgf3.L
uniprot id: B7ZPF9
uniprot id: P36386
names: Function
names: Similarity
messages: Belongs to the heparin-binding growth factors family.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.

8355:cspg4b.L
gene id: 8355:cspg4b.L
uniprot id: A0A1L8I2C8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:b2m.S
gene id: 8355:b2m.S
uniprot id: Q9IA97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta-2-microglobulin family.
messages: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
messages: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).
messages: Secreted

8355:LOC108695514
gene id: 8355:LOC108695514
uniprot id: A0A8J0T8K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

8355:casp6.L
gene id: 8355:casp6.L
uniprot id: A0A8J0TPH7
uniprot id: Q9IB66
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

8355:psmb1.S
gene id: 8355:psmb1.S
uniprot id: Q7ZYL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8355:atp6v1e1.S
gene id: 8355:atp6v1e1.S
uniprot id: A0A1L8GQM2
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

8355:atrn.L
gene id: 8355:atrn.L
uniprot id: A0A8J1MMU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108709281
gene id: 8355:LOC108709281
uniprot id: A0A1L8H5J9
uniprot id: A0A8J0UJJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

8355:LOC108699709
gene id: 8355:LOC108699709
uniprot id: A0A1L8EZM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8355:LOC108703435
gene id: 8355:LOC108703435
uniprot id: A0A8J1MQL7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:nhsl2.L
gene id: 8355:nhsl2.L
uniprot id: A0A1L8F6K7
uniprot id: A0A8J0TIT4
uniprot id: A0A8J1LGK9
uniprot id: A0A8J1LHH4
uniprot id: A0A8J1LIJ7
names: Similarity
messages: Belongs to the NHS family.

8355:sf3a2.L
gene id: 8355:sf3a2.L
uniprot id: Q3KQ40
names: Similarity
messages: Belongs to the SF3A2 family.

8355:LOC121403058
gene id: 8355:LOC121403058
uniprot id: A0A1L8GMI7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8355:LOC108701761
gene id: 8355:LOC108701761
uniprot id: A0A1L8ES74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:atrn.S
gene id: 8355:atrn.S
uniprot id: A0A1L8HKI6
uniprot id: A0A8J1M2N2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:efna2.L
gene id: 8355:efna2.L
uniprot id: A0A1L8HWH3
uniprot id: A0A8J1KKC6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108708464
gene id: 8355:LOC108708464
uniprot id: A0A1L8HH23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

8355:crat.L
gene id: 8355:crat.L
uniprot id: A0A1L8F8E7
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

8355:tmco1.S
gene id: 8355:tmco1.S
uniprot id: Q4FZN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108716954
gene id: 8355:LOC108716954
uniprot id: A0A8J1KSE6
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:mrps31.S
gene id: 8355:mrps31.S
uniprot id: A0A1L8HAF4
uniprot id: A0A8J0UKP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

8355:gk.L
gene id: 8355:gk.L
uniprot id: A0A1L8HGJ9
uniprot id: A0A8J0UFV9
uniprot id: A0A8J0UIC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

8355:f2.S
gene id: 8355:f2.S
uniprot id: Q6DFJ5
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

8355:rpl5.S
gene id: 8355:rpl5.S
uniprot id: Q8AVX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

8355:mapk4.S
gene id: 8355:mapk4.S
uniprot id: A0A1L8HS14
uniprot id: A0A8J0UB36
uniprot id: A0A8J1M4E8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

8355:por.S
gene id: 8355:por.S
uniprot id: A0A1L8H891
uniprot id: A0A8J0UKU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

8355:LOC108705562
gene id: 8355:LOC108705562
uniprot id: A0A8J1LIV7
names: Similarity
messages: Belongs to the MHC class I family.

8355:gpr182.L
gene id: 8355:gpr182.L
uniprot id: Q6PCH1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:sgo1.L
gene id: 8355:sgo1.L
uniprot id: Q4KLP8
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shugoshin family.
messages: Binds microtubules.
messages: High level during prophase and prometaphase and weaker after the chromosomes attach to the spindle and align at the metaphase plate. During anaphase, it is degraded, allowing the separation of sister centromeres (at protein level).
messages: Nucleus
messages: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase. May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes.
messages: Ubiquitinated by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation.
messages: centromere
messages: kinetochore

8355:ska1.L
gene id: 8355:ska1.L
uniprot id: A0A8J0VJB3
names: Similarity
messages: Belongs to the SKA1 family.

8355:igf2.L
gene id: 8355:igf2.L
uniprot id: A0A8J0V2Y8
uniprot id: Q6INW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Promotes anterior neural development. Acts as a ligand for integrin which is required for IGF2 signaling.

8355:cmtm7.L
gene id: 8355:cmtm7.L
uniprot id: Q6DFH1
names: Subcellular Location Annotation
messages: Membrane

8355:ykt6.S
gene id: 8355:ykt6.S
uniprot id: Q6DDU7
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Farnesylation is required for Golgi targeting.
messages: Golgi apparatus membrane
messages: Maternally inherited. Detected in oocytes and eggs. Expression declines during early development and is not detected in neurula, tailbud and tadpole embryos.
messages: Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.
messages: The longin domain regulates palmitoylation and membrane targeting.
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
messages: cytosol

8355:agxt2.S
gene id: 8355:agxt2.S
uniprot id: A0A1L8HRS1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

8355:hoxd1.L
gene id: 8355:hoxd1.L
uniprot id: A0A1L8EWB8
names: Subcellular Location Annotation
messages: Nucleus

8355:il10.L
gene id: 8355:il10.L
uniprot id: A0A1L8HER6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

8355:brinp3.L
gene id: 8355:brinp3.L
uniprot id: A0A8J0UXU2
names: Similarity
messages: Belongs to the BRINP family.

8355:ccnf.S
gene id: 8355:ccnf.S
uniprot id: A0A8J1LZG8
uniprot id: A0A8J1M0E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: centriole
messages: perinuclear region

8355:LOC121395060
gene id: 8355:LOC121395060
uniprot id: A0A8J1L1W5
names: Similarity
messages: Belongs to the group II decarboxylase family.

8355:hal.2.S
gene id: 8355:hal.2.S
uniprot id: Q6GMC2
names: Similarity
messages: Belongs to the PAL/histidase family.

8355:dnmt1.S
gene id: 8355:dnmt1.S
uniprot id: B1WBA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

8355:LOC108695797
gene id: 8355:LOC108695797
uniprot id: A0A8J1L5Q8
uniprot id: A0A8J1L5S8
uniprot id: A0A8J1L7G4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: cytosol

8355:hcfc1.S
gene id: 8355:hcfc1.S
uniprot id: A0A1L8F1Q9
uniprot id: A0A8J1LM48
uniprot id: Q640G9
names: Subcellular Location Annotation
messages: Nucleus

8355:dxo.L
gene id: 8355:dxo.L
uniprot id: Q5HZT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Exhibits decapping activity towards FAD-capped RNAs (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).
messages: Nucleus

8355:st3gal4.L
gene id: 8355:st3gal4.L
uniprot id: A0A8J0T8Q0
uniprot id: A0A8J0T9M1
uniprot id: A0A8J1L4M7
uniprot id: A0A8J1L4Q1
uniprot id: A0A8J1L6D5
uniprot id: Q4V814
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:LOC108706148
gene id: 8355:LOC108706148
uniprot id: A0A8J1LT16
uniprot id: A0A8J1LTN6
uniprot id: A0A8J1LUG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:LOC108698165
gene id: 8355:LOC108698165
uniprot id: A0A1L8F5Z0
uniprot id: A0A8J0T9T0
uniprot id: A0A8J0TFW3
uniprot id: A0A8J1LFE3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:grik4.L
gene id: 8355:grik4.L
uniprot id: A0A1L8FLD0
uniprot id: A0A8J1L6H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

8355:cpne1.L
gene id: 8355:cpne1.L
uniprot id: A0A8J0TRS1
uniprot id: Q6P7H2
names: Similarity
messages: Belongs to the copine family.

8355:atp5po.L
gene id: 8355:atp5po.L
uniprot id: Q3KQC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

8355:pitx2.S
gene id: 8355:pitx2.S
uniprot id: A0A8J0TNH4
uniprot id: Q6GNM5
uniprot id: Q9PWR3
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube.
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: By nodal/nr-1 in the left lateral plate mesoderm.
messages: May play an important role in development and maintenance of anterior structures and mediate left-right asymmetry. Could play a role at the interface of lateral plate signaling and heart and gut morphogenesis.
messages: Nucleus

8355:otoa.L
gene id: 8355:otoa.L
uniprot id: A0A1L8EXZ5
names: Similarity
messages: Belongs to the mesothelin family.

8355:themis.L
gene id: 8355:themis.L
uniprot id: A0A8J1KNG3
names: Similarity
messages: Belongs to the themis family.

8355:tmem135.L
gene id: 8355:tmem135.L
uniprot id: Q6GQ39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.
messages: Mitochondrion membrane
messages: Peroxisome membrane

8355:dhdds.S
gene id: 8355:dhdds.S
uniprot id: Q7ZYJ5
names: Similarity
messages: Belongs to the UPP synthase family.

8355:slc4a1.L
gene id: 8355:slc4a1.L
uniprot id: A0A1L8ESA0
uniprot id: A0A1L8ESA4
uniprot id: A0A8J0TRZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

8355:reln.L
gene id: 8355:reln.L
uniprot id: A0A1L8GZC4
uniprot id: A0A8J0URD1
uniprot id: A0A8J0UUM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

8355:marveld1.L
gene id: 8355:marveld1.L
uniprot id: A0A1L8FJE9
names: Subcellular Location Annotation
messages: Membrane

8355:pld3.S
gene id: 8355:pld3.S
uniprot id: A0A8J0THH5
uniprot id: A0A8J0TR86
uniprot id: A0A8J0TR91
names: Similarity
messages: Belongs to the phospholipase D family.

8355:XB5913776.L
gene id: 8355:XB5913776.L
uniprot id: A0A1L8I2A4
uniprot id: A0A8J0VGG9
uniprot id: A0A8J0VM14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

8355:LOC108699268
gene id: 8355:LOC108699268
uniprot id: A0A1L8FB17
names: Similarity
messages: Belongs to the PP1 inhibitor family.

8355:trnt1.L
gene id: 8355:trnt1.L
uniprot id: A0A8J1MVA6
uniprot id: Q32NP6
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

8355:LOC108700158
gene id: 8355:LOC108700158
uniprot id: A0A1L8F388
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:cbs.S
gene id: 8355:cbs.S
uniprot id: A0A8J0UIC2
uniprot id: Q6DDN9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

8355:fut6.S
gene id: 8355:fut6.S
uniprot id: Q7SZU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8355:csf3.L
gene id: 8355:csf3.L
uniprot id: A0A1L8ERX3
names: Similarity
messages: Belongs to the IL-6 superfamily.

8355:rcl1.L
gene id: 8355:rcl1.L
uniprot id: Q7ZXF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

8355:xrn2.L
gene id: 8355:xrn2.L
uniprot id: A0A1L8G7M9
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

8355:tmem208.S
gene id: 8355:tmem208.S
uniprot id: A0A1L8GFB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

8355:seh1l.S
gene id: 8355:seh1l.S
uniprot id: A0A8J1L0N0
uniprot id: Q6GNF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). Probably part of the GATOR complex.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore
messages: nuclear pore complex

8355:adam22.L
gene id: 8355:adam22.L
uniprot id: A0A8J0VED6
uniprot id: A0A8J0VH95
uniprot id: A0A8J1KY80
uniprot id: O42596
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Low levels in adult tissues. Not detected in developing embryos.
messages: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (By similarity).
messages: The precursor is cleaved by a furin endopeptidase.

8355:LOC108703519
gene id: 8355:LOC108703519
uniprot id: A0A8J0U206
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:hs3st1.L
gene id: 8355:hs3st1.L
uniprot id: Q6DJJ5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:tmem258.L
gene id: 8355:tmem258.L
uniprot id: Q6GP81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

8355:LOC121393914
gene id: 8355:LOC121393914
uniprot id: A0A8J1KQW3
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108698991
gene id: 8355:LOC108698991
uniprot id: A0A1L8FB87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108703472
gene id: 8355:LOC108703472
uniprot id: A0A8J0U1T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:cmtm3.L
gene id: 8355:cmtm3.L
uniprot id: A0A8J1MU11
uniprot id: A0A8J1MVG8
uniprot id: Q5PQA3
names: Subcellular Location Annotation
messages: Membrane

8355:cln8.L
gene id: 8355:cln8.L
uniprot id: Q68F07
names: Subcellular Location Annotation
messages: Membrane

8355:strn.S
gene id: 8355:strn.S
uniprot id: A0A8J0VAK5
uniprot id: Q66JA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

8355:dcn.S
gene id: 8355:dcn.S
uniprot id: Q6GNX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

8355:sox17b.1.S
gene id: 8355:sox17b.1.S
uniprot id: O42601
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed zygotically from late blastula stage. Expression is barely detectable during tailbud stages and is absent by stage 35 (early tadpole).
messages: In early gastrulae, expressed in the vegetal but not animal hemisphere. The vegetal region is fated to become endoderm and endodermal expression continues throughout gastrulation and neurulation. At tailbud stages, expression is barely detectable.
messages: Interacts (via C-terminus) with ctnnb1/beta-catenin (via Armadillo repeats); this interaction is required for inhibition of wnt-signaling.
messages: Involved in multiple regulatory feedback loops with other endodermal factors, including the nodal-related factors/Xnrs. Autoinduces. By activin. Directly by vegt; originally cell-autonomously and then cell contact is required for expression to be maintained. By bmp-signaling.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription activator. Doesn't appear to bind to the consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin-mediated signaling.

8355:gpr89b.L
gene id: 8355:gpr89b.L
uniprot id: Q6DDW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Golgi apparatus membrane
messages: Homotrimer.
messages: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (By similarity). Plays a role in lymphocyte development (By similarity).

8355:dlc.L
gene id: 8355:dlc.L
uniprot id: Q7ZXT4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

8355:hnf1b.S
gene id: 8355:hnf1b.S
uniprot id: Q7T0V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

8355:LOC108716137
gene id: 8355:LOC108716137
uniprot id: A0A8J1KNH3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

8355:sidt1.L
gene id: 8355:sidt1.L
uniprot id: A0A8J1M7P8
uniprot id: A0A8J1M8I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

8355:zfyve9.S
gene id: 8355:zfyve9.S
uniprot id: A0A1L8GFZ5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

8355:tmem150c.L
gene id: 8355:tmem150c.L
uniprot id: A0A1L8HVW1
names: Subcellular Location Annotation
messages: Membrane

8355:hs2st1.L
gene id: 8355:hs2st1.L
uniprot id: O93336
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfotransferase 3 family.
messages: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes (By similarity).
messages: Golgi apparatus membrane
messages: Homotrimer.

8355:snrpd3.S
gene id: 8355:snrpd3.S
uniprot id: Q8AVZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

8355:mon2.L
gene id: 8355:mon2.L
uniprot id: A0A8J1MH13
uniprot id: A0A8J1MH15
uniprot id: A0A8J1MIX8
uniprot id: Q6GP04
names: Function
names: Similarity
messages: Belongs to the MON2 family.
messages: May be required for traffic between late Golgi and early endosomes.

8355:LOC108712359
gene id: 8355:LOC108712359
uniprot id: A0A8J1MSN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

8355:LOC108705332
gene id: 8355:LOC108705332
uniprot id: A0A8J1MVI0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:hsbp1.S
gene id: 8355:hsbp1.S
uniprot id: Q5M7D3
names: Similarity
messages: Belongs to the HSBP1 family.

8355:psmd8.S
gene id: 8355:psmd8.S
uniprot id: A0A8J0TRB8
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

8355:psmd3.S
gene id: 8355:psmd3.S
uniprot id: Q6GNC1
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

8355:gnrhr2.L
gene id: 8355:gnrhr2.L
uniprot id: A0A1L8H0Y5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121403121
gene id: 8355:LOC121403121
uniprot id: A0A8J1MYA3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121394494
gene id: 8355:LOC121394494
uniprot id: A0A8J1KWB7
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:crygdl.6.S
gene id: 8355:crygdl.6.S
uniprot id: A0A1L8HNQ7
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:pip4k2c.S
gene id: 8355:pip4k2c.S
uniprot id: Q5PQ01
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity.
messages: Phosphorylated, phosphorylation is induced by EGF.

8355:map4k5.S
gene id: 8355:map4k5.S
uniprot id: A0A8J0PZN9
uniprot id: A0A8J1LNC0
uniprot id: Q68F04
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

8355:rcn3.L
gene id: 8355:rcn3.L
uniprot id: A0A8J0T8K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

8355:LOC108699606
gene id: 8355:LOC108699606
uniprot id: A0A1L8FD26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:XB5731801.S
gene id: 8355:XB5731801.S
uniprot id: A0A1L8ENU1
names: Similarity
messages: Belongs to the histone H2B family.

8355:MGC108147.L
gene id: 8355:MGC108147.L
uniprot id: A0A8J0T996
uniprot id: Q58EW4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:evx1.S
gene id: 8355:evx1.S
uniprot id: A0A8J0VQA8
names: Subcellular Location Annotation
messages: Nucleus

8355:efnb2.S
gene id: 8355:efnb2.S
uniprot id: B0FLR3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:hccs.L
gene id: 8355:hccs.L
uniprot id: Q7ZTL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

8355:gramd4.S
gene id: 8355:gramd4.S
uniprot id: A2RV80
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: Plays a role as a mediator of e2f1-induced apoptosis in the absence of p53/TP53.

8355:LOC108706612
gene id: 8355:LOC108706612
uniprot id: A0A8J0U813
uniprot id: A0A8J1M121
uniprot id: A0A8J1M171
uniprot id: A0A8J1M325
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ccnb2.S
gene id: 8355:ccnb2.S
uniprot id: A0A8J0UXL1
uniprot id: P13351
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
messages: Belongs to the cyclin family.
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
messages: Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdk1, interacts with spdya. Interacts with nap1l1.

8355:atp6v1a.L
gene id: 8355:atp6v1a.L
uniprot id: Q4KLX0
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

8355:LOC443727
gene id: 8355:LOC443727
uniprot id: Q7ZY41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

8355:ccni.S
gene id: 8355:ccni.S
uniprot id: A0A1L8HMI6
uniprot id: Q5RK38
names: Similarity
messages: Belongs to the cyclin family.

8355:acss1.S
gene id: 8355:acss1.S
uniprot id: A0A1L8G1P5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:ciao2b.L
gene id: 8355:ciao2b.L
uniprot id: Q5M9B8
names: Similarity
messages: Belongs to the MIP18 family.

8355:cul2.S
gene id: 8355:cul2.S
uniprot id: A0A1L8FQQ7
uniprot id: A0A8J0VMK9
names: Similarity
messages: Belongs to the cullin family.

8355:LOC108704545
gene id: 8355:LOC108704545
uniprot id: A0A8J0U5I9
uniprot id: A0A8J1M9B9
names: Function
names: Similarity
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.

8355:dner.L
gene id: 8355:dner.L
uniprot id: Q68EY0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108717644
gene id: 8355:LOC108717644
uniprot id: A0A1L8G0Y7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:wdr83os.L
gene id: 8355:wdr83os.L
uniprot id: Q6NTW8
names: Similarity
messages: Belongs to the Asterix family.

8355:LOC121397146
gene id: 8355:LOC121397146
uniprot id: A0A8J1LJL9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

8355:stag1.S
gene id: 8355:stag1.S
uniprot id: A0A8J1KRH3
uniprot id: A0A8J1KT14
uniprot id: Q9DGN1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
messages: Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1 OR STAG2). In cohesin complexes, STAG1 is mutually exclusive with STAG2.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).
messages: centromere

8355:LOC121393329
gene id: 8355:LOC121393329
uniprot id: A0A1L8GGA9
uniprot id: A0A8J1KMK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8355:sox14.S
gene id: 8355:sox14.S
uniprot id: B0ZTE2
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a negative regulator of transcription (By similarity). May function as a switch in neuronal development.
messages: First expressed at stage 25. Expression peaks at stage 28 and continues at this level throughout all later stages, until at least stage 38.
messages: In the developing embryo, restricted to the hypothalamus, dorsal thalamus, optic tectum, a region of the somatic motornucleus in the midbrain and hindbrain, the vestibular nuclei in the hindbrain, and a discrete ventral domain in the developing spinal cord.
messages: Nucleus

8355:nkd1.S
gene id: 8355:nkd1.S
uniprot id: A0A8J1KI52
uniprot id: A0A8J1KI62
uniprot id: A0A8J1KI67
uniprot id: A0A8J1KI78
uniprot id: A0A8J1KI82
uniprot id: A0A8J1KJY7
uniprot id: A0A8J1KJZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8355:osbpl3.S
gene id: 8355:osbpl3.S
uniprot id: A0A1L8FR93
uniprot id: A0A8J0VM41
uniprot id: A0A8J0VQA2
names: Similarity
messages: Belongs to the OSBP family.

8355:zc3h12a.S
gene id: 8355:zc3h12a.S
uniprot id: A0A1L8H7R5
names: Similarity
messages: Belongs to the ZC3H12 family.

8355:ran.S
gene id: 8355:ran.S
uniprot id: P52301
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Cytoplasm
messages: Detected throughout embryonic development (PubMed:11180838). Detected within the animal pole region at the four-cell stage, then in the anterior neural plate at the neurula stage, and within the head region including the otic vesicles, branchial arches, and the tail region at the tailbud stage (PubMed:11180838, PubMed:25946333).
messages: GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:8413630). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446). Required for normal progress through mitosis (By similarity). In concert with nemp1a/b, required for proper eye development (PubMed:25946333).
messages: Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
messages: Monomer. Interacts with rangap1, which promotes ran-mediated GTP hydrolysis. Interacts with kpnb1. Interaction with kpnb1 inhibits rangap1-mediated stimulation of GTPase activity. Interacts with rcc1 which promotes the exchange of ran-bound GDP by GTP. Interaction with kpnb1 inhibits rcc1-mediated exchange of ran-bound GDP by GTP. Interacts (GTP-bound form) with tnpo1; the interaction is direct. Interacts (GTP-bound form) with tnpo3; the interaction is direct. Interacts with kpnb1 and with tnpo1; both inhibit ran GTPase activity. Interacts (via C-terminus) with ranbp1, which alleviates the inhibition of ran GTPase activity. Interacts with rangrf, which promotes the release of bound guanine nucleotide. Rangrf and rcc1 compete for an overlapping binding site on ran. Identified in a complex with kpna2 and cse1l; interaction with ranbp1 mediates dissociation of ran from this complex. Interaction with both ranbp1 and kpna2 promotes dissociation of the complex between ran and kpnb1. Identified in a complex composed of ran, rangap1 and ranbp1. Identified in a complex that contains tnpo1, ran and ranbp1. Identified in a nuclear export complex with xpo1. Interaction with ranbp1 or ranbp2 induces a conformation change in the complex formed by xpo1 and ran that triggers the release of the nuclear export signal of cargo proteins. Component of a nuclear export receptor complex composed of kpnb1, ran, snupn and xpo1 (By similarity). Interacts with nemp1a and nemp1b (PubMed:25946333).
messages: Morpholino knockdown results in defects in eye development and reduction of cell density at the neurula stage. Co-knockdown of nemp1a/b and ran elicits reduction of cell density and eye defects more significantly than the individual knockdown of either one.
messages: Nucleus
messages: Nucleus envelope
messages: cytosol

8355:lix1l.L
gene id: 8355:lix1l.L
uniprot id: A0A8J1LJI5
names: Similarity
messages: Belongs to the LIX1 family.

8355:cmas.L
gene id: 8355:cmas.L
uniprot id: A0A1L8GVU4
names: Similarity
messages: Belongs to the CMP-NeuNAc synthase family.

8355:cab39l.L
gene id: 8355:cab39l.L
uniprot id: Q6PAB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

8355:LOC108704800
gene id: 8355:LOC108704800
uniprot id: A0A8J1LHR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

8355:LOC108706672
gene id: 8355:LOC108706672
uniprot id: A0A1L8HLT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

8355:gpd1.L
gene id: 8355:gpd1.L
uniprot id: Q7ZYM3
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

8355:glod4.L
gene id: 8355:glod4.L
uniprot id: Q6GPJ6
names: Similarity
messages: Belongs to the glyoxalase I family.

8355:pmt.S
gene id: 8355:pmt.S
uniprot id: Q6DCC9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:parp14.3.L
gene id: 8355:parp14.3.L
uniprot id: A0A1L8HXV4
uniprot id: A0A8J1KM58
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:LOC121394225
gene id: 8355:LOC121394225
uniprot id: A0A8J1KT61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8355:slc26a10.S
gene id: 8355:slc26a10.S
uniprot id: A0A1L8HA43
uniprot id: A0A8J1MG63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:ncoa1.S
gene id: 8355:ncoa1.S
uniprot id: A0A1L8G5Q8
uniprot id: A0A8J1KUQ2
uniprot id: A0A8J1KUQ7
uniprot id: A0A8J1KUQ9
uniprot id: A0A8J1KUR4
uniprot id: A0A8J1KUR5
uniprot id: A0A8J1KWA2
uniprot id: A0A8J1KXR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

8355:LOC108713414
gene id: 8355:LOC108713414
uniprot id: A0A1L8HXI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

8355:bxdc5
gene id: 8355:bxdc5
uniprot id: Q8AVP1
names: Function
names: Subcellular Location Annotation
messages: May be required for ribosome biogenesis.
messages: nucleolus

8355:abhd17b.L
gene id: 8355:abhd17b.L
uniprot id: Q6DCC5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Cell membrane
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards nras.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization.
messages: Postsynaptic density membrane
messages: Recycling endosome membrane
messages: dendritic spine

8355:LOC121400455
gene id: 8355:LOC121400455
uniprot id: A0A8J1MEN0
names: Subcellular Location Annotation
messages: Nucleus

8355:aldh1a1.L
gene id: 8355:aldh1a1.L
uniprot id: Q6DFL9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

8355:osbp2.L
gene id: 8355:osbp2.L
uniprot id: A0A1L8I1L5
names: Similarity
messages: Belongs to the OSBP family.

8355:birc5.L
gene id: 8355:birc5.L
uniprot id: Q4R1J6
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IAP family.
messages: C-terminus is required for spindle assembly.
messages: Component of the CPC at least composed of survivin/birc5, incenp, cdca8/borealin and/or cdca9/dasra-A, and aurkb/aurora-B. Interacts directly with incenp (via N-terminus), and may weakly interact with aurkb (via N-terminus) to stabilize the complex. Interacts with GTP-bound ran in both the S and M phases of the cell cycle. Also found in a complex with ubiquitin-mediated signaling proteins including at least usp9x/xFAM, nploc4/npl4 and ufd1 (By similarity).
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Stimulates the mitotic kinase activity of aurkb/aurora-B in the CPC. Does not appear to exhibit anti-apoptotic activity (By similarity). CPC. Does not appear to exhibit anti-apoptotic activity.
messages: Cytoplasm
messages: Expressed maternally. Expressed in the earliest stages of oocytes, and accumulates during oogenesis. Also present in early embryos with expression declining rapidly after the onset of zygotic transcription at the mid-blastula transition (MBT). Although PubMed:12454937 conclude that, with the exception of the ovary, expression is absent in adults, PubMed:16759290 suggest that expression is adult-specific and is absent in embryonic and tadpole stages between gastrulation and metamorphosis.
messages: Nucleus
messages: Ubiquitination is required for centrosome-targeting.
messages: centromere
messages: spindle

8355:parp12.S
gene id: 8355:parp12.S
uniprot id: A0A1L8GQL5
names: Similarity
messages: Belongs to the ARTD/PARP family.

8355:calm2.S
gene id: 8355:calm2.S
uniprot id: P0DP33
uniprot id: P0DP34
uniprot id: P0DP35
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

8355:admp2.L
gene id: 8355:admp2.L
uniprot id: A1E8I5
names: Similarity
messages: Belongs to the TGF-beta family.

8355:kcnmb2.S
gene id: 8355:kcnmb2.S
uniprot id: A0A1L8G425
names: Subcellular Location Annotation
messages: Membrane

8355:chga.S
gene id: 8355:chga.S
uniprot id: A0A1L8F0E9
uniprot id: A0A8J0TEX7
uniprot id: A0A8J0TLC0
uniprot id: Q5XHF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

8355:ovca2.L
gene id: 8355:ovca2.L
uniprot id: A0A8J0UDZ1
names: Similarity
messages: Belongs to the LovG family.

8355:sema6b.L
gene id: 8355:sema6b.L
uniprot id: A0A1L8HW98
uniprot id: A0A8J1KIA8
uniprot id: A0A8J1KK16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:or52l1l100487582.L
gene id: 8355:or52l1l100487582.L
uniprot id: A0A8J0UG01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:uroc1.L
gene id: 8355:uroc1.L
uniprot id: Q498I6
names: Similarity
messages: Belongs to the urocanase family.

8355:mrpl10.S
gene id: 8355:mrpl10.S
uniprot id: A0A1L8EKY9
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

8355:LOC121393417
gene id: 8355:LOC121393417
uniprot id: A0A8J1KKJ1
names: Subcellular Location Annotation
messages: Membrane

8355:pnliprp1.S
gene id: 8355:pnliprp1.S
uniprot id: A0A1L8FDS7
uniprot id: A0A8J1LAA7
uniprot id: A0A8J1LAE0
uniprot id: Q642R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

8355:nanos3.S
gene id: 8355:nanos3.S
uniprot id: A0A8J0U1Y4
uniprot id: A0A8J0U390
names: Similarity
messages: Belongs to the nanos family.

8355:ncaph2.L
gene id: 8355:ncaph2.L
uniprot id: Q641G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
messages: Component of the condensin-2 complex, which contains the smc2 and smc4 heterodimer, and three non SMC subunits, ncapg2, ncaph2 and ncapd3 that probably regulate the complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture.

8355:stbd1.L
gene id: 8355:stbd1.L
uniprot id: A0A1L8HVI6
names: Similarity
messages: Belongs to the FAM47 family.

8355:fezf1.S
gene id: 8355:fezf1.S
uniprot id: Q9IAJ2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed during mid/late-gastrulation at the rostro-medial regions of the anterior neural plate. Expression becomes more pronounced as neurulation progresses and remains localized within the prospective telencephalic region. By stage 46, expressed in the olfactory bulbs, nervus terminalis, ventral hypothalamic nucleus, and ventricular zone.
messages: Nucleus
messages: Transcription repressor. Involved in the development of the forebrain region.

8355:dipk1a.L
gene id: 8355:dipk1a.L
uniprot id: Q6DCL6
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

8355:cryga.7.S
gene id: 8355:cryga.7.S
uniprot id: A0A8J1LX07
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:krt78.6.L
gene id: 8355:krt78.6.L
uniprot id: A0A1L8HIN1
names: Similarity
messages: Belongs to the intermediate filament family.

8355:ocm4.9.L
gene id: 8355:ocm4.9.L
uniprot id: Q8AVP4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8355:med22.S
gene id: 8355:med22.S
uniprot id: A0A1L8F180
uniprot id: A0A8J0TG39
uniprot id: A0A8J0TML0
uniprot id: A0A8J1LQK3
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

8355:psph.L
gene id: 8355:psph.L
uniprot id: A0A1L8HG72
uniprot id: Q6DFU1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

8355:nfkb1.S
gene id: 8355:nfkb1.S
uniprot id: A0A8J0UB68
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:hvcn1.S
gene id: 8355:hvcn1.S
uniprot id: A0A1L8HQR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

8355:sema6a.S
gene id: 8355:sema6a.S
uniprot id: A0A1L8HR11
uniprot id: A0A8J0UAH6
uniprot id: A0A8J0UD60
uniprot id: A0A8J1M4Y9
uniprot id: A0A8J1M4Z4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108701194
gene id: 8355:LOC108701194
uniprot id: A0A8J0TWP3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:wif1.L
gene id: 8355:wif1.L
uniprot id: A0A1L8GYI2
uniprot id: A0A8J0UIF9
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108703562
gene id: 8355:LOC108703562
uniprot id: A0A8J0TUV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:XB5798854.L
gene id: 8355:XB5798854.L
uniprot id: A0A1L8G0F1
uniprot id: A0A8J0VH56
uniprot id: Q7SZ00
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108700899
gene id: 8355:LOC108700899
uniprot id: A0A1L8ESU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8355:arrdc2.S
gene id: 8355:arrdc2.S
uniprot id: A0A1L8HN40
uniprot id: Q08AZ2
names: Similarity
messages: Belongs to the arrestin family.

8355:ufm1.S
gene id: 8355:ufm1.S
uniprot id: A0A1L8HAE9
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

8355:aldh18a1.L
gene id: 8355:aldh18a1.L
uniprot id: A0A1L8FJ61
uniprot id: A0A8J0T688
uniprot id: A0A8J1L4D8
uniprot id: A0A8J1L4E0
uniprot id: A0A8J1L642
uniprot id: Q6GMF0
names: Similarity
messages: In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
messages: In the N-terminal section; belongs to the glutamate 5-kinase family.

8355:tyrp1.L
gene id: 8355:tyrp1.L
uniprot id: Q7ZYE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8355:inhbb.L
gene id: 8355:inhbb.L
uniprot id: Q91350
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

8355:dlst.L
gene id: 8355:dlst.L
uniprot id: A0A8J0TJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

8355:osbpl6.L
gene id: 8355:osbpl6.L
uniprot id: A0A1L8EWE6
uniprot id: A0A8J0TV66
names: Similarity
messages: Belongs to the OSBP family.

8355:idh3a.S
gene id: 8355:idh3a.S
uniprot id: A0A8J0UMM0
uniprot id: Q6GN63
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

8355:LOC108707775
gene id: 8355:LOC108707775
uniprot id: A0A1L8HBX4
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

8355:cdc42se1.L
gene id: 8355:cdc42se1.L
uniprot id: Q6GPV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
messages: cytoskeleton

8355:galr3.S
gene id: 8355:galr3.S
uniprot id: A0A1L8GH70
uniprot id: A0A8J0V6Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:hoga1.L
gene id: 8355:hoga1.L
uniprot id: Q5XGL6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.
messages: Inhibited by divalent cations.
messages: Mitochondrion

8355:myf5.L
gene id: 8355:myf5.L
uniprot id: P24700
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8355:dym.L
gene id: 8355:dym.L
uniprot id: A0A8J1M7J7
uniprot id: Q6DCP6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dymeclin family.
messages: Cytoplasm
messages: Golgi apparatus
messages: Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.
messages: Necessary for correct organization of Golgi apparatus.

8355:acsm3.L
gene id: 8355:acsm3.L
uniprot id: Q6DJK1
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

8355:med14.S
gene id: 8355:med14.S
uniprot id: A0A8J1MD74
uniprot id: A0A8J1MDP5
uniprot id: A0A8J1MF39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:LOC121400389
gene id: 8355:LOC121400389
uniprot id: A0A310UCL5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:gnb4.S
gene id: 8355:gnb4.S
uniprot id: A0A1L8G482
uniprot id: Q5U587
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

8355:stxbp1.L
gene id: 8355:stxbp1.L
uniprot id: A0A8J1LEB8
uniprot id: Q68F22
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

8355:cdc42bpa.S
gene id: 8355:cdc42bpa.S
uniprot id: A0A8J0VJY9
uniprot id: A0A8J1KS61
uniprot id: A0A8J1KS78
uniprot id: A0A8J1KTT1
uniprot id: A0A8J1KV99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: lamellipodium

8355:chaf1a.S
gene id: 8355:chaf1a.S
uniprot id: A0JMT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHAF1A family.
messages: Homodimer.
messages: Involved in chromatin assembly in DNA replication and DNA repair.
messages: Nucleus

8355:LOC108714671
gene id: 8355:LOC108714671
uniprot id: A0A8J1MYA9
uniprot id: A0A8J1MZT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

8355:or6s1.S
gene id: 8355:or6s1.S
uniprot id: A0A1L8HPR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:pygl.L
gene id: 8355:pygl.L
uniprot id: A0A1L8F9Y5
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

8355:gdi2.S
gene id: 8355:gdi2.S
uniprot id: A0A1L8GTQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

8355:slc16a14.S
gene id: 8355:slc16a14.S
uniprot id: A0A1L8G4R7
names: Subcellular Location Annotation
messages: Membrane

8355:hspb6.L
gene id: 8355:hspb6.L
uniprot id: Q6DJI2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:pafah1b1.S
gene id: 8355:pafah1b1.S
uniprot id: A0A1L8H632
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: centrosome
messages: cytoskeleton

8355:LOC108697006
gene id: 8355:LOC108697006
uniprot id: A0A1L8FLV2
uniprot id: A0A8J1L6T4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

8355:MGC76132.L
gene id: 8355:MGC76132.L
uniprot id: Q6GPT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferritin family.
messages: Oligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8355:LOC108708892
gene id: 8355:LOC108708892
uniprot id: A0A1L8H684
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:ndp.L
gene id: 8355:ndp.L
uniprot id: A0A1L8HF49
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:parl.L
gene id: 8355:parl.L
uniprot id: A0A1L8HEJ5
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108713304
gene id: 8355:LOC108713304
uniprot id: A0A1L8GVM7
uniprot id: A0A8J0US37
uniprot id: A0A8J0UX87
uniprot id: A0A8J0UYF8
uniprot id: A0A8J1MSA9
uniprot id: A0A8J1MSB5
uniprot id: A0A8J1MSC6
uniprot id: A0A8J1MSD1
uniprot id: A0A8J1MSD6
uniprot id: A0A8J1MSG3
uniprot id: A0A8J1MSG8
uniprot id: A0A8J1MSH4
uniprot id: A0A8J1MSI0
uniprot id: A0A8J1MSI5
uniprot id: A0A8J1MSJ0
uniprot id: A0A8J1MTC6
uniprot id: A0A8J1MTD1
uniprot id: A0A8J1MTD6
uniprot id: A0A8J1MTE1
uniprot id: A0A8J1MTE6
uniprot id: A0A8J1MTF1
uniprot id: A0A8J1MTN1
uniprot id: A0A8J1MTN6
uniprot id: A0A8J1MTP2
uniprot id: A0A8J1MTP7
uniprot id: A0A8J1MTQ1
uniprot id: A0A8J1MTQ6
uniprot id: A0A8J1MUM2
uniprot id: A0A8J1MUM7
uniprot id: A0A8J1MUN3
uniprot id: A0A8J1MUN8
uniprot id: A0A8J1MUP2
uniprot id: A0A8J1MUP7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8355:ccnl1.S
gene id: 8355:ccnl1.S
uniprot id: A0A8J0VG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

8355:prss16.L
gene id: 8355:prss16.L
uniprot id: Q5HZ74
names: Similarity
messages: Belongs to the peptidase S28 family.

8355:rasgrp3.L
gene id: 8355:rasgrp3.L
uniprot id: A0A8J0VFY3
uniprot id: A0A8J1KMW0
uniprot id: A0A8J1KMW1
names: Similarity
messages: Belongs to the RASGRP family.

8355:txndc5.L
gene id: 8355:txndc5.L
uniprot id: Q7ZX44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

8355:LOC108711533
gene id: 8355:LOC108711533
uniprot id: A0A1L8H1C8
uniprot id: A0A8J0UW67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:rrp8.S
gene id: 8355:rrp8.S
uniprot id: A0A1L8HBP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Probable methyltransferase required to silence rDNA.
messages: nucleolus

8355:cemip.S
gene id: 8355:cemip.S
uniprot id: A0A1L8GSM0
uniprot id: A0A8J0UVD4
names: Similarity
messages: Belongs to the CEMIP family.

8355:dlat.L
gene id: 8355:dlat.L
uniprot id: A0AUS4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

8355:sf3b4.L
gene id: 8355:sf3b4.L
uniprot id: A0A8J1LEM3
uniprot id: Q6AZR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

8355:LOC108699097
gene id: 8355:LOC108699097
uniprot id: A0A1L8FC28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:carmil1.S
gene id: 8355:carmil1.S
uniprot id: A0A8J1L2C8
uniprot id: A0A8J1L2C9
uniprot id: A0A8J1L2D0
uniprot id: A0A8J1L3Z6
uniprot id: A0A8J1L541
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

8355:cox16.L
gene id: 8355:cox16.L
uniprot id: A0A1L8FAQ9
uniprot id: A0A8J0TLR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

8355:MGC69074
gene id: 8355:MGC69074
uniprot id: Q7T0Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

8355:pnrc2.S
gene id: 8355:pnrc2.S
uniprot id: Q5XH28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
messages: Nucleus
messages: P-body

8355:LOC121397967
gene id: 8355:LOC121397967
uniprot id: A0A8J1LU38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:gpr156.S
gene id: 8355:gpr156.S
uniprot id: A0A1L8H5N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:rin1.S
gene id: 8355:rin1.S
uniprot id: A0A1L8GD82
uniprot id: A0A8J1KGU1
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

8355:LOC108695951
gene id: 8355:LOC108695951
uniprot id: A0A8J0T8Z8
names: Subcellular Location Annotation
messages: Membrane

8355:fmo2.L
gene id: 8355:fmo2.L
uniprot id: A0A8J1MTR2
uniprot id: Q6PA74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8355:tbxa2r.S
gene id: 8355:tbxa2r.S
uniprot id: A0A1L8HMZ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108699946
gene id: 8355:LOC108699946
uniprot id: A0A1L8F1I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

8355:mrpl3.S
gene id: 8355:mrpl3.S
uniprot id: A0A8J0VIY2
uniprot id: Q5XHI1
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

8355:ttc19.S
gene id: 8355:ttc19.S
uniprot id: A0A8J1MC40
uniprot id: A0A8J1MCJ5
names: Similarity
messages: Belongs to the TTC19 family.

8355:LOC108695647
gene id: 8355:LOC108695647
uniprot id: A0A1L8HZQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:heg1.L
gene id: 8355:heg1.L
uniprot id: A0A1L8EV87
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:crhr1.2.L
gene id: 8355:crhr1.2.L
uniprot id: A0A1L8ESI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8355:LOC108710159
gene id: 8355:LOC108710159
uniprot id: A0A1L8H2U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:cyld.L
gene id: 8355:cyld.L
uniprot id: A0A1L8GKP3
names: Subcellular Location Annotation
messages: centrosome
messages: perinuclear region

8355:elk1.S
gene id: 8355:elk1.S
uniprot id: A0A8J1LKC6
uniprot id: B5AIC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8355:jak1.S
gene id: 8355:jak1.S
uniprot id: Q6DDJ0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

8355:LOC108698116
gene id: 8355:LOC108698116
uniprot id: A0A1L8F5M0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:glis3.L
gene id: 8355:glis3.L
uniprot id: A0A1L8HY67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

8355:LOC108699189
gene id: 8355:LOC108699189
uniprot id: A0A8J0TD40
uniprot id: A0A8J0TJC7
uniprot id: A0A8J0TKV9
uniprot id: A0A8J0TKW6
uniprot id: A0A8J0TLQ0
uniprot id: A0A8J0TMQ1
uniprot id: A0A8J1LIT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

8355:ehd2.S
gene id: 8355:ehd2.S
uniprot id: Q6GQG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

8355:fgf5.S
gene id: 8355:fgf5.S
uniprot id: A0A1L8HN19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

8355:plin3.S
gene id: 8355:plin3.S
uniprot id: Q6DE12
names: Similarity
messages: Belongs to the perilipin family.

8355:edc3.S
gene id: 8355:edc3.S
uniprot id: A0A1L8GT95
uniprot id: A0A8J0UY63
uniprot id: Q5XH48
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).
messages: P-body
messages: The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with other proteins (By similarity).

8355:LOC121402255
gene id: 8355:LOC121402255
uniprot id: A0A8J1MTW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:nxph3.L
gene id: 8355:nxph3.L
uniprot id: A0A1L8ES85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

8355:cep20.L
gene id: 8355:cep20.L
uniprot id: A0A1L8EXM0
uniprot id: Q4V7R8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CEP43 family.
messages: Cytoplasmic granule
messages: Homooligomer; probably required for localization to centrosomes.
messages: Involved in the biogenesis of cilia (By similarity). Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity).
messages: centriolar satellite
messages: centrosome
messages: cilium
messages: cilium basal body

8355:smoc1.S
gene id: 8355:smoc1.S
uniprot id: A0A1L8EZP4
uniprot id: A0A8J1LM55
uniprot id: A0A8J1LMA5
uniprot id: A0A8J1LN94
uniprot id: A0A8J1LN96
uniprot id: A0A8J1LPN4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:tcea1.L
gene id: 8355:tcea1.L
uniprot id: A0A8J0VF33
uniprot id: Q91980
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

8355:upk1b.S
gene id: 8355:upk1b.S
uniprot id: A0A8J1MBK1
uniprot id: A0A8J1MDC2
uniprot id: Q6DJM8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

8355:LOC121399384
gene id: 8355:LOC121399384
uniprot id: A0A8J1M4D7
names: Similarity
messages: Belongs to the cyclin family.

8355:tspan36.S
gene id: 8355:tspan36.S
uniprot id: Q6GP11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC121395680
gene id: 8355:LOC121395680
uniprot id: A0A8J1L881
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108708683
gene id: 8355:LOC108708683
uniprot id: A0A1L8HIT8
names: Subcellular Location Annotation
messages: Membrane

8355:fdxr.L
gene id: 8355:fdxr.L
uniprot id: Q5XGT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion

8355:bsg.S
gene id: 8355:bsg.S
uniprot id: A0A1L8HNR0
uniprot id: Q4FZV9
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lateral cell membrane

8355:LOC108712768
gene id: 8355:LOC108712768
uniprot id: A0A1L8HWN3
uniprot id: A0A8J0UPI0
names: Subcellular Location Annotation
messages: Nucleus

8355:slc2a11.3.S
gene id: 8355:slc2a11.3.S
uniprot id: A0A1L8HQA9
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:LOC108716196
gene id: 8355:LOC108716196
uniprot id: A0A8J1KPD1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:abcg2.S
gene id: 8355:abcg2.S
uniprot id: A0A1L8HME0
uniprot id: A0A8J0U8W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

8355:LOC108703544
gene id: 8355:LOC108703544
uniprot id: A0A8J0U3D0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8355:irf7.L
gene id: 8355:irf7.L
uniprot id: A0A1L8GJP7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:dbf4.L
gene id: 8355:dbf4.L
uniprot id: Q7ZZH7
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex with cdc7.
messages: Nucleus
messages: Phosphorylated.
messages: Present throughout development. During the cell cycle progression, levels in egg extracts do not change. Appears during the first 12 hours of development, and they further increases significantly between 12 and 24 hours. Not present in oocytes I-VI but it is detected at maturation. The level of protein remains constant from mature oocytes to stage 8.5 embryos but increases after mid-blastula (at protein level).
messages: Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Not required during the initiation of DNA replication in egg and during early embryonic development but is required later and throughout development. The complex cdc7-dbf4a phosphorylates mcm2 subunit.

8355:pam.L
gene id: 8355:pam.L
uniprot id: A0A1L8I1N2
uniprot id: A0A1L8I1N5
uniprot id: A0A8J1MT72
uniprot id: P08478
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
messages: Binds 2 copper ions per subunit for the monooxygenase reaction.
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: Monomer.
messages: Zn(2+) is required for the lyase reaction.
messages: secretory vesicle membrane

8355:supt3h.L
gene id: 8355:supt3h.L
uniprot id: A0A8J0Q045
uniprot id: A0A8J0VE17
uniprot id: A0A8J1KLI2
uniprot id: Q6AX62
names: Subcellular Location Annotation
messages: Nucleus

8355:atp5pb.L
gene id: 8355:atp5pb.L
uniprot id: Q640C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

8355:LOC108718528
gene id: 8355:LOC108718528
uniprot id: A0A8J0VJ93
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:trim9.S
gene id: 8355:trim9.S
uniprot id: A0A1L8F061
uniprot id: A0A8J0TFJ6
uniprot id: A0A8J0TNA2
uniprot id: A0A8J0TP67
uniprot id: A0A8J0TQ82
names: Subcellular Location Annotation
messages: cytoskeleton

8355:cuedc2.S
gene id: 8355:cuedc2.S
uniprot id: Q6NU18
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: May play a role in targeting proteins for ubiquitination and subsequent proteasomal degradation.
messages: Nucleus
messages: Phosphorylated.

8355:ikbkb.L
gene id: 8355:ikbkb.L
uniprot id: Q6INT1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:XB1000829.S
gene id: 8355:XB1000829.S
uniprot id: Q640Y3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:LOC108699012
gene id: 8355:LOC108699012
uniprot id: A0A8J0TKI3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:naa25.L
gene id: 8355:naa25.L
uniprot id: A0A8J0V8H0
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

8355:neurod2.L
gene id: 8355:neurod2.L
uniprot id: A0A1L8ERW7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108710022
gene id: 8355:LOC108710022
uniprot id: A0A1L8HB42
uniprot id: A0A8J0UQC3
uniprot id: A0A8J1MFN1
uniprot id: A0A8J1MGL0
uniprot id: A0A8J1MHG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

8355:LOC108719319
gene id: 8355:LOC108719319
uniprot id: A0A8J1KYT0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:ep300.S
gene id: 8355:ep300.S
uniprot id: A0A1L8GGS2
uniprot id: A0A1L8GGW2
uniprot id: A0A8J0V3B0
uniprot id: A0A8J0V6R4
uniprot id: A0A8J0V6R9
uniprot id: A0A8J0V825
uniprot id: A0A8J0VC59
names: Subcellular Location Annotation
messages: Cytoplasm

8355:LOC108699365
gene id: 8355:LOC108699365
uniprot id: A0A1L8FBX1
uniprot id: A0A8J0TMB7
uniprot id: A0A8J1LIU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

8355:ccng2.L
gene id: 8355:ccng2.L
uniprot id: Q6GM00
names: Similarity
messages: Belongs to the cyclin family.

8355:utp23.S
gene id: 8355:utp23.S
uniprot id: A0A8J1L318
names: Subcellular Location Annotation
messages: nucleolus

8355:isyna1.S
gene id: 8355:isyna1.S
uniprot id: A0A1L8HNP7
uniprot id: Q7ZXY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol 1-phosphate synthase family.
messages: Cytoplasm
messages: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity).

8355:LOC108695396
gene id: 8355:LOC108695396
uniprot id: A0A1L8FTL5
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121395694
gene id: 8355:LOC121395694
uniprot id: A0A8J1L8M6
uniprot id: A0A8J1LA84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

8355:dtx3.S
gene id: 8355:dtx3.S
uniprot id: A0A8J1MF71
uniprot id: A0A8J1MF73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

8355:epn3.S
gene id: 8355:epn3.S
uniprot id: A0A1L8EMS6
names: Similarity
messages: Belongs to the epsin family.

8355:vipr2.S
gene id: 8355:vipr2.S
uniprot id: A0A8J1L2T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8355:tmem138.L
gene id: 8355:tmem138.L
uniprot id: A0A1L8GJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

8355:tdgf1.1.L
gene id: 8355:tdgf1.1.L
uniprot id: A0A8J0UN48
uniprot id: Q2VU94
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:traf4.S
gene id: 8355:traf4.S
uniprot id: A0A1L8H4T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8355:rab3b.L
gene id: 8355:rab3b.L
uniprot id: Q6GLK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

8355:fgd1.S
gene id: 8355:fgd1.S
uniprot id: A0A1L8F1R3
uniprot id: A0A8J0TQ31
names: Subcellular Location Annotation
messages: cytoskeleton

8355:LOC108705151
gene id: 8355:LOC108705151
uniprot id: A0A310TP18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:polr1d.2.L
gene id: 8355:polr1d.2.L
uniprot id: Q5XK67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
messages: Nucleus

8355:cadps.L
gene id: 8355:cadps.L
uniprot id: Q6GLR7
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) (By similarity).
messages: Homodimer.
messages: Synapse
messages: The PH domain is essential for regulated exocytosis and binds phospholipids.
messages: neuronal dense core vesicle membrane

8355:LOC108709936
gene id: 8355:LOC108709936
uniprot id: A0A1L8HAJ4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

8355:tmeff1.S
gene id: 8355:tmeff1.S
uniprot id: A0A1L8FS36
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:nsdhl.S
gene id: 8355:nsdhl.S
uniprot id: A0A1L8F399
names: Similarity
messages: Belongs to the 3-beta-HSD family.

8355:snx5.L
gene id: 8355:snx5.L
uniprot id: Q5HZZ2
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

8355:dpm2.S
gene id: 8355:dpm2.S
uniprot id: Q641S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

8355:LOC108697740
gene id: 8355:LOC108697740
uniprot id: A0A1L8HT29
uniprot id: A0A8J0T765
names: Similarity
messages: Belongs to the lst-2 family.

8355:eme1.L
gene id: 8355:eme1.L
uniprot id: A9ULX4
names: Similarity
messages: Belongs to the EME1/MMS4 family.

8355:crhr1.2.S
gene id: 8355:crhr1.2.S
uniprot id: B7ZPZ9
uniprot id: O42602
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
messages: Interacts (via N-terminal extracellular domain) with CRF and UCN.
messages: Membrane
messages: The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).

8355:styx.L
gene id: 8355:styx.L
uniprot id: Q4V7N3
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: Catalytically inactive phosphatase.
messages: Contains a Gly residue instead of a conserved Cys residue at position 120 in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (By similarity). The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and may protect them from phosphatases (By similarity).

8355:rnf43.S
gene id: 8355:rnf43.S
uniprot id: A0A1L8H5W0
uniprot id: A0A8J0UJP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

8355:lmln.L
gene id: 8355:lmln.L
uniprot id: A0A1L8EV77
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.

8355:atp13a4.S
gene id: 8355:atp13a4.S
uniprot id: A0A8J0PX20
uniprot id: A0A8J0VDS5
uniprot id: A0A8J0VEM1
uniprot id: A0A8J0VJ18
uniprot id: Q6DDF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:prfprl2.1.L
gene id: 8355:prfprl2.1.L
uniprot id: A0A8J1MPB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

8355:slc31a1.L
gene id: 8355:slc31a1.L
uniprot id: A0A1L8F5P7
uniprot id: Q7SZ99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

8355:arl5b.S
gene id: 8355:arl5b.S
uniprot id: Q5M783
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8355:anxa6.S
gene id: 8355:anxa6.S
uniprot id: A0A1L8GR56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

8355:LOC108717827
gene id: 8355:LOC108717827
uniprot id: A0A1L8G1Z1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

8355:LOC108719563
gene id: 8355:LOC108719563
uniprot id: A0A1L8FUP1
names: Similarity
messages: Belongs to the histone H3 family.

8355:LOC108695727
gene id: 8355:LOC108695727
uniprot id: A0A1L8FIK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108701945
gene id: 8355:LOC108701945
uniprot id: A0A1L8EZ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:dbnl.S
gene id: 8355:dbnl.S
uniprot id: Q6GM14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein that binds F-actin and dynamin, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation. Does not bind G-actin and promote actin polymerization by itself, but excerts its functions by interaction with other proteins. Required for the formation of organized podosome rosettes (By similarity).
messages: Belongs to the ABP1 family.
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Synapse
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: cytoskeleton
messages: cytosol
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

8355:txnrd3.L
gene id: 8355:txnrd3.L
uniprot id: A0A8J0PYE6
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

8355:ubqln1.S
gene id: 8355:ubqln1.S
uniprot id: A0A1L8HPE5
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

8355:LOC121398276
gene id: 8355:LOC121398276
uniprot id: A0A8J1LUJ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:cadm3.S
gene id: 8355:cadm3.S
uniprot id: A0A8J1LMI6
uniprot id: A0A8J1LNU7
names: Similarity
messages: Belongs to the nectin family.

8355:wnt9a.S
gene id: 8355:wnt9a.S
uniprot id: A0A1L8FQF4
uniprot id: A0A8J0VJ64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:grk6.S
gene id: 8355:grk6.S
uniprot id: A0A8J1MRC1
uniprot id: Q68F06
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

8355:htr7.L
gene id: 8355:htr7.L
uniprot id: A0A8J0TAW4
uniprot id: A0A8J1L552
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:mrpl46.S
gene id: 8355:mrpl46.S
uniprot id: A0A1L8GSM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

8355:fitm2.S
gene id: 8355:fitm2.S
uniprot id: A0A8J0U1C2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:msi2.S
gene id: 8355:msi2.S
uniprot id: A0A8J1MBA3
uniprot id: A0A8J1MC96
uniprot id: A0A8J1MD17
uniprot id: Q91920
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

8355:LOC108708382
gene id: 8355:LOC108708382
uniprot id: A0A1L8HGQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:LOC108719490
gene id: 8355:LOC108719490
uniprot id: A0A1L8G0E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8355:galnt9.L
gene id: 8355:galnt9.L
uniprot id: A0A1L8I1B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

8355:dnal4.L
gene id: 8355:dnal4.L
uniprot id: A0A8J0V268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

8355:LOC108700658
gene id: 8355:LOC108700658
uniprot id: A0A8J0TT67
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121400605
gene id: 8355:LOC121400605
uniprot id: A0A8J1ME14
names: Similarity
messages: Belongs to the DDIT4 family.

8355:os9.L
gene id: 8355:os9.L
uniprot id: A0A1L8HI75
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

8355:hexb.L
gene id: 8355:hexb.L
uniprot id: A0A1L8I1Z7
uniprot id: A0A8J0VEX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

8355:sdhaf2.S
gene id: 8355:sdhaf2.S
uniprot id: A0A1L8GDF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

8355:LOC121399446
gene id: 8355:LOC121399446
uniprot id: A0A1L8HPG2
uniprot id: A0A8J1M473
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108699407
gene id: 8355:LOC108699407
uniprot id: A0A8J1LIU7
names: Similarity
messages: Belongs to the MHC class I family.

8355:wls.L
gene id: 8355:wls.L
uniprot id: Q5FWK6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the wntless family.
messages: Cytoplasmic vesicle membrane
messages: Enriched in the animal hemisphere of the early cleavage embryo, where expression persists until the late gastrula stage. At the neurula stage, strongly expressed at the border of the neural plate and dorsal midline. After the neurula stage, expressed in various organs, including the eye, liver, heart, pronephros, otic vesicle, and dorsal neural tube. Expression in the developing eye is dynamic; expressed in the eye field from stages 23 to 27, and from stage 30 expression is confined to distinct regions including the central part and border of the eye.
messages: Expressed both maternally and zygotically, with zygotic expression continuing to the tadpole stage (stage 42).
messages: Golgi apparatus membrane
messages: Required for a subset of Wnt-dependent developmental processes, in particular, eye and pronephros development. Regulates the secretion of wnt4, which is required for eye development.

8355:LOC108705862
gene id: 8355:LOC108705862
uniprot id: A0A8J1LBD6
names: Subcellular Location Annotation
messages: acrosome

8355:abhd6.L
gene id: 8355:abhd6.L
uniprot id: Q7SY73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Late endosome membrane
messages: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity).
messages: Lysosome membrane
messages: Mitochondrion membrane

8355:vbp1.L
gene id: 8355:vbp1.L
uniprot id: Q7SYV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

8355:coq10a.S
gene id: 8355:coq10a.S
uniprot id: A0A1L8H9L4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

8355:camk2g.L
gene id: 8355:camk2g.L
uniprot id: A0A1L8FJZ5
uniprot id: A0A8J0T192
uniprot id: A0A8J0T198
uniprot id: A0A8J0T1A4
uniprot id: A0A8J0T1A9
uniprot id: A0A8J0T7Y1
uniprot id: A0A8J0T7Y5
uniprot id: A0A8J0T7Y9
uniprot id: A0A8J0T7Z4
uniprot id: A0A8J0TA01
uniprot id: A0A8J0TA05
uniprot id: A0A8J0TA11
uniprot id: A0A8J0TA16
uniprot id: A0A8J0TA99
uniprot id: A0A8J0TAA4
uniprot id: A0A8J0TB41
uniprot id: A0A8J0TB44
uniprot id: A0A8J0TB50
uniprot id: A0A8J1L5G1
uniprot id: A0A8J1L5G5
uniprot id: A0A8J1L5G7
uniprot id: A0A8J1L5H0
uniprot id: A0A8J1L5H4
uniprot id: A0A8J1L5I2
uniprot id: A0A8J1L5I6
uniprot id: A0A8J1L5J4
uniprot id: A0A8J1L769
uniprot id: A0A8J1L774
uniprot id: A0A8J1L783
uniprot id: A0A8J1L875
uniprot id: A0A8J1L889
uniprot id: Q9DFZ8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

8355:fga.S
gene id: 8355:fga.S
uniprot id: Q7ZTR1
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

8355:LOC108713285
gene id: 8355:LOC108713285
uniprot id: A0A1L8GVE8
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

8355:phkb.S
gene id: 8355:phkb.S
uniprot id: A0A1L8GF35
uniprot id: A0A8J0V732
uniprot id: A0A8J1KIN2
uniprot id: A0A8J1KIQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

8355:nid2.S
gene id: 8355:nid2.S
uniprot id: A0A1L8F057
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

8355:wnt16.S
gene id: 8355:wnt16.S
uniprot id: A0A1L8GU45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:LOC108719302
gene id: 8355:LOC108719302
uniprot id: A0A1L8FZ87
uniprot id: A0A8J1L1K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

8355:tprkb.L
gene id: 8355:tprkb.L
uniprot id: A0A8J1MH63
uniprot id: Q6DE45
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

8355:cldn14.L
gene id: 8355:cldn14.L
uniprot id: Q6GME4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8355:immp2l.L
gene id: 8355:immp2l.L
uniprot id: Q5PQ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

8355:trappc3l.S
gene id: 8355:trappc3l.S
uniprot id: A0A1L8G2U7
uniprot id: A0A8J1KWA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

8355:wbp4.L
gene id: 8355:wbp4.L
uniprot id: Q6DD78
names: Subcellular Location Annotation
messages: Nucleus

8355:psmd2.S
gene id: 8355:psmd2.S
uniprot id: Q4KLW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

8355:adgrf1.S
gene id: 8355:adgrf1.S
uniprot id: A0A1L8G597
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

8355:afmid.L
gene id: 8355:afmid.L
uniprot id: A0A1L8ETN8
uniprot id: A0A8J1LS35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

8355:LOC108698253
gene id: 8355:LOC108698253
uniprot id: A0A8J1LJY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8355:n6amt1.L
gene id: 8355:n6amt1.L
uniprot id: Q4V7J7
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

8355:hoxa2.L
gene id: 8355:hoxa2.L
uniprot id: Q9DEZ1
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108710373
gene id: 8355:LOC108710373
uniprot id: A0A8J0UGI2
names: Similarity
messages: Belongs to the GOLGA6 family.

8355:sbno2.S
gene id: 8355:sbno2.S
uniprot id: A0A1L8HNA8
uniprot id: A0A8J0U8X9
uniprot id: A0A8J1M2B6
uniprot id: A0A8J1M2E0
names: Similarity
messages: Belongs to the SBNO family.

8355:slc6a9.S
gene id: 8355:slc6a9.S
uniprot id: A0A1L8GFQ3
uniprot id: A0A8J1KJ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

8355:ptma.L
gene id: 8355:ptma.L
uniprot id: A0A8J0U4L5
uniprot id: Q5U274
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pro/parathymosin family.
messages: Nucleus

8355:cpsf4.L
gene id: 8355:cpsf4.L
uniprot id: A0A1L8EXA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

8355:LOC779362
gene id: 8355:LOC779362
uniprot id: Q90VX7
names: Subcellular Location Annotation
messages: Cytoplasm

8355:thoc5.S
gene id: 8355:thoc5.S
uniprot id: A0A8J0TT92
uniprot id: Q7ZXA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
messages: Belongs to the THOC5 family.
messages: Component of the THO subcomplex of the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with thoc7.
messages: Cytoplasm
messages: May be involved in cell differentiation.
messages: Nucleus
messages: Nucleus speckle

8355:krt7.S
gene id: 8355:krt7.S
uniprot id: A0A1L8HAE0
names: Similarity
messages: Belongs to the intermediate filament family.

8355:arpc5l.L
gene id: 8355:arpc5l.L
uniprot id: Q6DE18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Nucleus
messages: cytoskeleton

8355:cand1.L
gene id: 8355:cand1.L
uniprot id: Q6DKM0
names: Similarity
messages: Belongs to the CAND family.

8355:LOC108699542
gene id: 8355:LOC108699542
uniprot id: A0A8J1LJU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

8355:LOC121397992
gene id: 8355:LOC121397992
uniprot id: A0A1L8EZC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108706197
gene id: 8355:LOC108706197
uniprot id: A0A8J0U7T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

8355:pla2g2e.S
gene id: 8355:pla2g2e.S
uniprot id: Q66L11
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

8355:LOC108697164
gene id: 8355:LOC108697164
uniprot id: A0A1L8FDZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:dgkk.L
gene id: 8355:dgkk.L
uniprot id: A0A1L8F6M3
uniprot id: A0A8J0TA50
uniprot id: A0A8J0TG96
uniprot id: A0A8J0TJN9
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

8355:mid1.L
gene id: 8355:mid1.L
uniprot id: D8WX02
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

8355:eif3e.L
gene id: 8355:eif3e.L
uniprot id: Q05AY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Nucleus

8355:mtmr12.L
gene id: 8355:mtmr12.L
uniprot id: A0A1L8I2N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Sarcoplasmic reticulum
messages: sarcomere

8355:acp7.L
gene id: 8355:acp7.L
uniprot id: A0A1L8F943
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

8355:cyp27c1.L
gene id: 8355:cyp27c1.L
uniprot id: Q66IQ5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:usp3.S
gene id: 8355:usp3.S
uniprot id: A0A1L8GTD1
uniprot id: A0A8J0UVY8
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:prkca.L
gene id: 8355:prkca.L
uniprot id: A0A8J1LPV0
uniprot id: A0A8J1LQS3
uniprot id: Q6AZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

8355:LOC108704874
gene id: 8355:LOC108704874
uniprot id: A0A8J1MKR5
names: Similarity
messages: Belongs to the peptidase M10A family.

8355:ddx25.L
gene id: 8355:ddx25.L
uniprot id: A0A8J1L488
uniprot id: B1WBD2
uniprot id: Q9DGP9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: ATP-dependent RNA helicase.
messages: An mRNA component of germ plasm. Localizes to the granulo-fibrillar material (GFM) of the mitochondrial cloud in stage I oocytes. Associated, at a low level, with the periphery of mature germinal granules in later stage oocytes. Localizes to the vegetal cortex in stage II oocytes and segregates with germ plasm during early embryogenesis. In adults, expression is restricted to the ovary and, at a lower level, to spermatogonia, spermatocytes and spermatids of the testis.
messages: Belongs to the DEAD box helicase family.
messages: Cytoplasm
messages: Expressed at a constant level throughout oogenesis and in the egg. Levels decrease during gastrulation and are not detectable by the end of gastrulation.
messages: Nucleus

8355:LOC108716372
gene id: 8355:LOC108716372
uniprot id: A0A1L8GBJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

8355:tp53inp1.S
gene id: 8355:tp53inp1.S
uniprot id: Q640I5
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

8355:rnf112.S
gene id: 8355:rnf112.S
uniprot id: A0A1L8ERH8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:LOC108709264
gene id: 8355:LOC108709264
uniprot id: A0A1L8H5G7
uniprot id: A0A8J0UBF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC121398878
gene id: 8355:LOC121398878
uniprot id: A0A8J1LZ71
names: Similarity
messages: Belongs to the LRRFIP family.

8355:serf2.L
gene id: 8355:serf2.L
uniprot id: A0A8J0USD1
names: Similarity
messages: Belongs to the SERF family.

8355:c19orf54.S
gene id: 8355:c19orf54.S
uniprot id: A0A1L8F3V5
names: Similarity
messages: Belongs to the UPF0692 family.

8355:cdk1.S
gene id: 8355:cdk1.S
uniprot id: P35567
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with spdya.
messages: Nucleus
messages: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.
messages: Phosphorylation at Tyr-15 by wee1 and wee2 inhibits the protein kinase activity and acts negative regulator of entry into mitosis (G2 to M transition).
messages: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. May play a role in regulating the amplitude of the cyclic expression of circadian clock genes.

8355:LOC108709063
gene id: 8355:LOC108709063
uniprot id: A0A1L8HBM7
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8355:cacnb3.L
gene id: 8355:cacnb3.L
uniprot id: A0A8J1M4Y4
uniprot id: Q91629
names: Subcellular Location Annotation
messages: Cytoplasm

8355:khdrbs2.S
gene id: 8355:khdrbs2.S
uniprot id: A0A1L8G3H8
names: Similarity
messages: Belongs to the KHDRBS family.

8355:LOC121401418
gene id: 8355:LOC121401418
uniprot id: A0A8J1MKN9
names: Subcellular Location Annotation
messages: Nucleus

8355:mcidas.S
gene id: 8355:mcidas.S
uniprot id: A0A8J1LF96
uniprot id: Q08B36
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the geminin family.
messages: Component of the EDM complex, at least composed of e2f4, e2f5, mcidas and tfdp1.
messages: Down-regulated by Notch signaling.
messages: Expressed in multiciliate differentiating cells. Expression is lost by stage 26, when multiciliate cells in the skin are fully differentiated, but is then detected in the developing nephrostomes of the kidneys where multiciliate cells form at later stages.
messages: Nucleus
messages: The TIRT domain mediates interaction with e2f4 and tfdp1.
messages: Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Activates genes required for centriole assembly (plk4, cep152) and genes specifically required for motile cilia formation (foxj1). Also promotes the deuterosome pathway of centriole biogenesis by activating expression of ccdc67/deup1, but not its paralog cep63.

8355:nrxn3.L
gene id: 8355:nrxn3.L
uniprot id: A0A8J0THZ6
uniprot id: A0A8J1LH76
uniprot id: A0A8J1LH81
uniprot id: A0A8J1LH84
uniprot id: A0A8J1LH89
uniprot id: A0A8J1LHA6
uniprot id: A0A8J1LHB2
uniprot id: A0A8J1LHB6
uniprot id: A0A8J1LHC3
uniprot id: A0A8J1LHT3
uniprot id: A0A8J1LHT8
uniprot id: A0A8J1LHU2
uniprot id: A0A8J1LHU5
uniprot id: A0A8J1LIK5
uniprot id: A0A8J1LIL0
uniprot id: A0A8J1LIL6
uniprot id: A0A8J1LIM1
uniprot id: A0A8J1LJN8
uniprot id: A0A8J1LJP4
uniprot id: A0A8J1LJP8
uniprot id: A0A8J1LJQ3
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:aox1.S
gene id: 8355:aox1.S
uniprot id: Q6GMC5
names: Cofactor
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.

8355:gpr55.L
gene id: 8355:gpr55.L
uniprot id: A0A1L8GB19
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:fgf12.L
gene id: 8355:fgf12.L
uniprot id: A0A1L8G9Q1
uniprot id: A0A8J0VC38
uniprot id: A0A8J1KPE5
uniprot id: A0A8J1KPF1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:bod1.L
gene id: 8355:bod1.L
uniprot id: Q6DFL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
messages: centrosome
messages: kinetochore

8355:tgm1.S
gene id: 8355:tgm1.S
uniprot id: A0A8J0U6D0
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8355:ptch1.S
gene id: 8355:ptch1.S
uniprot id: A0A8J0TJF1
uniprot id: A0A8J0TT39
uniprot id: Q98SW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

8355:denr.L
gene id: 8355:denr.L
uniprot id: Q6GLZ1
names: Function
names: Similarity
messages: Belongs to the DENR family.
messages: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).

8355:rspo1.S
gene id: 8355:rspo1.S
uniprot id: A0A8J0UKN1
names: Similarity
messages: Belongs to the R-spondin family.

8355:LOC108718789
gene id: 8355:LOC108718789
uniprot id: A0A1L8I2Y5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:pabir3.L
gene id: 8355:pabir3.L
uniprot id: A0A8J0TI68
uniprot id: Q6GQ07
names: Similarity
messages: Belongs to the FAM122 family.

8355:slitrk3.S
gene id: 8355:slitrk3.S
uniprot id: A0A1L8G443
names: Similarity
messages: Belongs to the SLITRK family.

8355:shbg.S
gene id: 8355:shbg.S
uniprot id: A0A8J1MQC1
uniprot id: A0A8J1MRG5
uniprot id: Q5U524
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ccnj.L
gene id: 8355:ccnj.L
uniprot id: A0A1L8FJ67
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC121400431
gene id: 8355:LOC121400431
uniprot id: A0A8J1MD34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108698294
gene id: 8355:LOC108698294
uniprot id: A0A1L8F6U0
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:babam1.L
gene id: 8355:babam1.L
uniprot id: Q6DJG6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM1 family.
messages: Component of the ARISC complex, at least composed of uimc1/rap80, abraxas1, brcc3/brcc36, BABAM2 and babam1/nba1. Component of the BRCA1-A complex, at least composed of brca1, bard1, uimc1/rap80, abraxas1, brcc3/brcc36, BABAM2 and babam1/nba1. In the BRCA1-A complex, interacts directly with abraxas1 and BABAM2. Component of the BRISC complex, at least composed of abraxas2, brcc3/brcc36, babam2 and babam1/nba1.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of babam2 and help the 'Lys-63'-linked deubiquitinase activity mediated by brcc3/brcc36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.
messages: Cytoplasm
messages: Nucleus
messages: The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.

8355:add3.L
gene id: 8355:add3.L
uniprot id: Q4KLW7
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

8355:bpnt1.L
gene id: 8355:bpnt1.L
uniprot id: Q6DCL1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8355:stac2.L
gene id: 8355:stac2.L
uniprot id: A0A1L8ERZ7
names: Subcellular Location Annotation
messages: sarcolemma

8355:rnf112l.L
gene id: 8355:rnf112l.L
uniprot id: A0A8J0U3G4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:rfc5.L
gene id: 8355:rfc5.L
uniprot id: Q7ZTM5
names: Similarity
messages: Belongs to the activator 1 small subunits family.

8355:senp5.L
gene id: 8355:senp5.L
uniprot id: B6RQN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

8355:LOC108704575
gene id: 8355:LOC108704575
uniprot id: A0A8J0TX43
uniprot id: A0A8J0U4A9
uniprot id: A0A8J0U4Y2
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

8355:naxe.L
gene id: 8355:naxe.L
uniprot id: A0A1L8FCB7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted

8355:btg5.1.S
gene id: 8355:btg5.1.S
uniprot id: A0A8J1LDU8
names: Similarity
messages: Belongs to the BTG family.

8355:LOC121397934
gene id: 8355:LOC121397934
uniprot id: A0A8J1LSA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actinoporin family. Sea anemone subfamily.
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

8355:usp2.L
gene id: 8355:usp2.L
uniprot id: A0A1L8FLG3
uniprot id: A0A8J0TBS5
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:LOC108700686
gene id: 8355:LOC108700686
uniprot id: A0A8J0TR47
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC108696050
gene id: 8355:LOC108696050
uniprot id: A0A1L8FII3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

8355:hexim1.L
gene id: 8355:hexim1.L
uniprot id: Q4V7W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEXIM family.
messages: Cytoplasm
messages: Homooligomer and heterooligomer. Core component of the 7SK RNP complex.
messages: Nucleus
messages: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

8355:khdrbs3.S
gene id: 8355:khdrbs3.S
uniprot id: A0A1L8FU15
names: Similarity
messages: Belongs to the KHDRBS family.

8355:cacna1h.L
gene id: 8355:cacna1h.L
uniprot id: A0A8J0TWG3
uniprot id: A0A8J1LSR6
uniprot id: A0A8J1LUE0
names: Subcellular Location Annotation
messages: Membrane

8355:pgat.L
gene id: 8355:pgat.L
uniprot id: O73622
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An mRNA and protein component of germ plasm and primordial germ cells (PGCs) throughout oogenesis and early development, being first localized to the granulo-fibrillar material (GFM) of the mitochondrial cloud in stage I and II oocytes and to the periphery of mature germinal granules both in oocytes and in embryos. Shows some somatic expression including the ectodermal cells of tailbud embryos. In adults, only expressed in ovaries.
messages: Cytoplasm
messages: Expressed both maternally and zygotically from at least the pre-vitellogenic stage I of oogenesis through to the tadpole stages.
messages: Interacts with poc1b.
messages: Nucleus
messages: Probably plays a role in germ plasm formation, positioning and maintenance.

8355:LOC108712967
gene id: 8355:LOC108712967
uniprot id: A0A1L8GT81
uniprot id: A0A8J0UVT4
uniprot id: A0A8J1MR43
uniprot id: A0A8J1MR89
uniprot id: A0A8J1MSE1
uniprot id: A0A8J1MTE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

8355:zic2.L
gene id: 8355:zic2.L
uniprot id: Q91689
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: By zic1, zic2, zic3 and zic5.
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Continuously expressed from the egg to the tailbud stage (stage 30) with an increase in expression at the early gastrula stage (stage 10).
messages: Expressed in both animal and vegetal regions of the oocyte. At blastula and gastrula stages (stages 9 to 10.5), expressed throughout the ectoderm. During late gastrula to neurula stages, expression gradually diminishes in the midline region of the neural plate and increases in the anterior neural folds, and continues to be expressed in the posterior medial part of the neural plate. In early tailbud stages (stages 22-23), expressed in the dorsal forebrain, midbrain and hindbrain. Subsequently expressed in the telencephalon and diencephalon/mesencephalon boundary. In the spinal cord, expression is restricted to the dorsal most region including the roof plate. Also expressed in the somites and eye vesicles. In the eye, expression is restricted to the ciliary marginal zone of neural retina and is absent from the lens.
messages: Nucleus
messages: The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
messages: Transcriptional repressor that inhibits neurogenesis and induces neural and neural crest differentiation. Regulates anteroposterior patterning in early development by inhibiting expression of the nodal genes through the inhibition of vegt. Required for gastrulation movements and for proper anterior neural and axial development. May also act as a transcriptional activator. May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.

8355:septin2.L
gene id: 8355:septin2.L
uniprot id: A0A8J0V9A4
uniprot id: A0A8J1KMT5
uniprot id: B7ZR20
uniprot id: Q9DE33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium. Required for the progression through mitosis through regulation of chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation (By similarity). Probably plays a role in ciliogenesis and collective cell movements including convergent extension during gastrulation. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Controls cell shape and not polarization of cells during convergent extension.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Can form heterooligomers with other family members and form filaments. Interacts with wdpcp.
messages: cilium membrane
messages: cytoskeleton
messages: spindle

8355:pias1.S
gene id: 8355:pias1.S
uniprot id: A0A1L8GSB5
uniprot id: A0A8J0UPN5
names: Similarity
messages: Belongs to the PIAS family.

8355:hap1.S
gene id: 8355:hap1.S
uniprot id: A0A8J0TRB7
uniprot id: A0A8J0TYN6
uniprot id: A0A8J0TZV7
uniprot id: A0A8J0U1J7
uniprot id: A0A8J1LZQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

8355:fam199x.S
gene id: 8355:fam199x.S
uniprot id: Q6DDX3
names: Similarity
messages: Belongs to the FAM199 family.

8355:csnk1g3.L
gene id: 8355:csnk1g3.L
uniprot id: A1L1H1
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

8355:gpi.S
gene id: 8355:gpi.S
uniprot id: Q6GP33
names: Similarity
messages: Belongs to the GPI family.

8355:sh3bgrl.L
gene id: 8355:sh3bgrl.L
uniprot id: Q58E92
names: Similarity
messages: Belongs to the SH3BGR family.

8355:eps8l3.S
gene id: 8355:eps8l3.S
uniprot id: A0A8J0UH79
uniprot id: Q5XH20
names: Similarity
messages: Belongs to the EPS8 family.

8355:ctsb.S
gene id: 8355:ctsb.S
uniprot id: Q7ZXM4
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:LOC108704047
gene id: 8355:LOC108704047
uniprot id: A0A8J1LUM3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:osbpl9.L
gene id: 8355:osbpl9.L
uniprot id: A0A1L8GME2
uniprot id: A0A8J0UX05
uniprot id: A0A8J0V1C5
uniprot id: A0A8J1MWZ1
uniprot id: A0A8J1MWZ6
uniprot id: A0A8J1MX88
uniprot id: A0A8J1MX92
uniprot id: A0A8J1MY58
uniprot id: A0A8J1MYP8
uniprot id: A0A8J1MZG7
uniprot id: A0A8J1MZH2
names: Similarity
messages: Belongs to the OSBP family.

8355:hnrnpul2.L
gene id: 8355:hnrnpul2.L
uniprot id: A0A1L8GJU0
uniprot id: A0A8J0UZQ5
names: Subcellular Location Annotation
messages: Nucleus

8355:gldn.L
gene id: 8355:gldn.L
uniprot id: A0A1L8H0J1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:laptm4a.L
gene id: 8355:laptm4a.L
uniprot id: Q5PPZ7
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

8355:mtmr10.L
gene id: 8355:mtmr10.L
uniprot id: Q6NU08
names: Caution
names: Similarity
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 390 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

8355:pkn2.S
gene id: 8355:pkn2.S
uniprot id: A0A1L8GGA4
uniprot id: A0A8J0V7A0
uniprot id: A0A8J0V7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

8355:kremen1.S
gene id: 8355:kremen1.S
uniprot id: Q90Y90
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with lrp6.
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 proteins to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (PubMed:17978005, PubMed:18314504).

8355:nuf2.S
gene id: 8355:nuf2.S
uniprot id: A0A8J1KL67
uniprot id: Q6GQ71
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which is composed of ndc80, cdca1, spbc24 and spbc25. The NDC80 complex interacts with mis12 and zwint (By similarity).
messages: Contaminating sequence. Potential poly-A sequence.
messages: Nucleus
messages: kinetochore

8355:tmem98.L
gene id: 8355:tmem98.L
uniprot id: Q6INX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Secreted
messages: extracellular exosome

8355:stambpl1.L
gene id: 8355:stambpl1.L
uniprot id: A0A1L8FII0
uniprot id: Q6GLN8
names: Similarity
messages: Belongs to the peptidase M67C family.

8355:dbnl.L
gene id: 8355:dbnl.L
uniprot id: A0A8J1MGN2
uniprot id: Q7ZXQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein that binds F-actin and dynamin, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation. Does not bind G-actin and promote actin polymerization by itself, but excerts its functions by interaction with other proteins. Required for the formation of organized podosome rosettes (By similarity).
messages: Belongs to the ABP1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Synapse
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: cytoskeleton
messages: cytosol
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

8355:ndufb3.L
gene id: 8355:ndufb3.L
uniprot id: A0A1L8EWT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

8355:lin7c.L
gene id: 8355:lin7c.L
uniprot id: Q7ZYU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.

8355:spon2.L
gene id: 8355:spon2.L
uniprot id: A0A1L8HT05
names: Subcellular Location Annotation
messages: extracellular matrix

8355:LOC108702031
gene id: 8355:LOC108702031
uniprot id: A0A1L8ET41
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

8355:LOC121399885
gene id: 8355:LOC121399885
uniprot id: A0A8J1M7V9
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108706715
gene id: 8355:LOC108706715
uniprot id: A0A8J1M2P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

8355:eif2a.S
gene id: 8355:eif2a.S
uniprot id: A0A1L8G4H4
uniprot id: A0A8J0VD90
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

8355:LOC108714650
gene id: 8355:LOC108714650
uniprot id: A0A1L8GPK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

8355:sh2b3.L
gene id: 8355:sh2b3.L
uniprot id: A0A1L8I157
names: Similarity
messages: Belongs to the SH2B adapter family.

8355:lyrm4.L
gene id: 8355:lyrm4.L
uniprot id: Q6DCS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Mitochondrion
messages: Nucleus
messages: Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.

8355:otx1.L
gene id: 8355:otx1.L
uniprot id: Q0IH93
uniprot id: Q98SI7
names: Subcellular Location Annotation
messages: Nucleus

8355:astl2d.1.L
gene id: 8355:astl2d.1.L
uniprot id: A0A8J1MWQ9
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:scarb2.S
gene id: 8355:scarb2.S
uniprot id: Q5XH33
names: Similarity
messages: Belongs to the CD36 family.

8355:LOC121393575
gene id: 8355:LOC121393575
uniprot id: A0A1L8GCE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:sptssb.L
gene id: 8355:sptssb.L
uniprot id: A0A1L8GAP0
uniprot id: Q66J05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPTSS family. SPTSSB subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with sptlc1; the interaction is direct. Component of the serine palmitoyltransferase (SPT) complex (By similarity).
messages: Interacts with sptlc1; the interaction is direct. Component of the serine palmitoyltransferase (SPT) complex.
messages: Membrane
messages: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (By similarity).
messages: Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference.

8355:LOC108698796
gene id: 8355:LOC108698796
uniprot id: A0A8J0TKW9
uniprot id: A0A8J1LIW9
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

8355:ube2h.S
gene id: 8355:ube2h.S
uniprot id: A0A1L8GTK1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8355:LOC121399206
gene id: 8355:LOC121399206
uniprot id: A0A8J1M1M8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108710233
gene id: 8355:LOC108710233
uniprot id: A0A8J1MJZ6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:cbs.L
gene id: 8355:cbs.L
uniprot id: Q7ZXW6
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

8355:selenot.L
gene id: 8355:selenot.L
uniprot id: A0A8J0PNW7
names: Similarity
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.

8355:LOC121395688
gene id: 8355:LOC121395688
uniprot id: A0A8J1L8M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

8355:fam102b.S
gene id: 8355:fam102b.S
uniprot id: A0A1L8GGK8
uniprot id: A0A8J1KJJ7
names: Similarity
messages: Belongs to the FAM102 family.

8355:selp.L
gene id: 8355:selp.L
uniprot id: A0A1L8GNL2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:slc26a2.2.S
gene id: 8355:slc26a2.2.S
uniprot id: A0A1L8GV37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

8355:LOC121402081
gene id: 8355:LOC121402081
uniprot id: A0A8J1MPM5
names: Subcellular Location Annotation
messages: Secreted

8355:nodal.S
gene id: 8355:nodal.S
uniprot id: A0A1L8FF18
names: Similarity
messages: Belongs to the TGF-beta family.

8355:kdrl.S
gene id: 8355:kdrl.S
uniprot id: A0A8J1LM51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:apold1.S
gene id: 8355:apold1.S
uniprot id: A0A1L8GGS7
names: Similarity
messages: Belongs to the apolipoprotein L family.

8355:dnm1l.S
gene id: 8355:dnm1l.S
uniprot id: A0A8J1MPS2
uniprot id: Q7ZXR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

8355:LOC108698813
gene id: 8355:LOC108698813
uniprot id: A0A1L8FA44
names: Subcellular Location Annotation
messages: Membrane

8355:syne3.L
gene id: 8355:syne3.L
uniprot id: A0A8J0TC09
uniprot id: A0A8J0TC14
uniprot id: A0A8J0TC21
uniprot id: A0A8J0TI78
uniprot id: A0A8J0TI83
uniprot id: A0A8J0TI89
uniprot id: A0A8J0TJU4
uniprot id: A0A8J0TJU8
uniprot id: A0A8J0TJV3
uniprot id: A0A8J0TJV8
uniprot id: A0A8J0TKM2
uniprot id: A0A8J0TKM7
uniprot id: A0A8J0TKN2
uniprot id: A0A8J0TLL5
uniprot id: A0A8J0TLM5
uniprot id: A0A8J1LHC0
uniprot id: A0A8J1LHF7
uniprot id: A0A8J1LHY0
uniprot id: A0A8J1LIQ4
uniprot id: A0A8J1LIQ9
uniprot id: A0A8J1LJT5
names: Similarity
messages: Belongs to the nesprin family.

8355:fbln7.S
gene id: 8355:fbln7.S
uniprot id: A0A8J0VBV1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:vangl1.S
gene id: 8355:vangl1.S
uniprot id: A0A1L8H5Y3
uniprot id: A0A8J0UBL7
uniprot id: A0A8J0UMG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

8355:evpl.L
gene id: 8355:evpl.L
uniprot id: A0A8J1LWQ8
names: Subcellular Location Annotation
messages: cytoskeleton

8355:vps13a.L
gene id: 8355:vps13a.L
uniprot id: Q63ZN2
names: Similarity
messages: Belongs to the VPS13 family.

8355:pgp.L
gene id: 8355:pgp.L
uniprot id: A0A1L8EYJ4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

8355:dis3l2.S
gene id: 8355:dis3l2.S
uniprot id: A0A1L8G451
uniprot id: A0A8J0VFY9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

8355:pik3r1.S
gene id: 8355:pik3r1.S
uniprot id: A0A8J0TSN4
uniprot id: A0A8J1LM99
uniprot id: B3DLK8
uniprot id: Q8UUU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PI3K p85 subunit family.
messages: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
messages: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits.

8355:sdc2.L
gene id: 8355:sdc2.L
uniprot id: Q3KQ99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

8355:tnfaip6.S
gene id: 8355:tnfaip6.S
uniprot id: A0A1L8EP24
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:fut9.L
gene id: 8355:fut9.L
uniprot id: A0A1L8G9Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8355:LOC108704179
gene id: 8355:LOC108704179
uniprot id: A0A8J1LYG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm

8355:LOC121398225
gene id: 8355:LOC121398225
uniprot id: A0A1L8EY79
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

8355:septin7.L
gene id: 8355:septin7.L
uniprot id: A0A8J0VES9
uniprot id: A0A8J0VHI4
uniprot id: A0A8J1KXA6
uniprot id: A0A8J1KYQ2
uniprot id: Q6GLZ5
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Coordinated expression with septin2 and septin6.
messages: Cytoplasm
messages: Expressed in the mesoderm during gastrulation. Expressed in the notochord of neurula stage embryos.
messages: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis (By similarity). Plays a role in ciliogenesis and collective cell movements including convergent extension during gastrulation. Controls cell elongation but not polarization during convergent extension.
messages: Midbody
messages: Monomer, and homodimer. Nucleotide binding promotes oligomerization. Can form heterooligomers with other family members and form filaments (By similarity).
messages: cilium axoneme
messages: kinetochore
messages: spindle

8355:pigl.L
gene id: 8355:pigl.L
uniprot id: A0A1L8HD05
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

8355:LOC121401340
gene id: 8355:LOC121401340
uniprot id: A0A8J1MJW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:rxfp2.L
gene id: 8355:rxfp2.L
uniprot id: A0A1L8HJ11
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:chm.S
gene id: 8355:chm.S
uniprot id: A0A1L8F350
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

8355:gbe1.S
gene id: 8355:gbe1.S
uniprot id: Q5XG45
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

8355:mtmr3.L
gene id: 8355:mtmr3.L
uniprot id: Q6PCI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

8355:LOC108697989
gene id: 8355:LOC108697989
uniprot id: A0A1L8FGZ7
uniprot id: A0A8J1LAV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

8355:dhx29.L
gene id: 8355:dhx29.L
uniprot id: A3KMI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC).

8355:nipsnap1.L
gene id: 8355:nipsnap1.L
uniprot id: A8WH45
names: Similarity
messages: Belongs to the NipSnap family.

8355:ccndx.L
gene id: 8355:ccndx.L
uniprot id: Q641B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

8355:LOC108718970
gene id: 8355:LOC108718970
uniprot id: A0A1L8I3A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

8355:nr2f2.L
gene id: 8355:nr2f2.L
uniprot id: A0A8J0UN28
uniprot id: Q7ZXI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8355:epn1.S
gene id: 8355:epn1.S
uniprot id: A0A1L8FGP3
uniprot id: A0A8J0T4N1
uniprot id: A0A8J0TAT8
uniprot id: A0A8J0TCU0
uniprot id: A0A8J0TCU5
uniprot id: A0A8J0TDH6
uniprot id: A0A8J0TDI1
uniprot id: A0A8J0TE68
uniprot id: A0A8J0TE75
uniprot id: A0A8J1LA09
uniprot id: A0A8J1LA42
uniprot id: O13027
names: Similarity
messages: Belongs to the epsin family.

8355:cnep1r1.S
gene id: 8355:cnep1r1.S
uniprot id: A0A8J1MWA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

8355:cyp2r1.S
gene id: 8355:cyp2r1.S
uniprot id: A0A1L8GDX6
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:pitx3.S
gene id: 8355:pitx3.S
uniprot id: Q9I8K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus
messages: Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons. May play a role in the normal lens development and differentiation (By similarity).

8355:LOC108720068
gene id: 8355:LOC108720068
uniprot id: A0A1L8FSA0
uniprot id: A0A8J1L4U6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:fgf10.S
gene id: 8355:fgf10.S
uniprot id: B5LX82
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

8355:LOC108710437
gene id: 8355:LOC108710437
uniprot id: A0A1L8H3L3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108719076
gene id: 8355:LOC108719076
uniprot id: A0A8J0VGX0
uniprot id: A0A8J0VJH7
uniprot id: A0A8J1KZJ6
uniprot id: A0A8J1L0V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:tfap2a.S
gene id: 8355:tfap2a.S
uniprot id: A0A1L8FS35
uniprot id: A0A8J0VIZ8
uniprot id: A0A8J0VL65
uniprot id: A0A8J0VLF7
uniprot id: A0A8J0VMC4
uniprot id: A0A8J1L0S6
uniprot id: A0A8J1L3J4
uniprot id: Q63ZP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

8355:cnnm2.L
gene id: 8355:cnnm2.L
uniprot id: A0A310TRI6
uniprot id: A0A8J0U5U8
uniprot id: A0A8J1L4Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

8355:LOC108705600
gene id: 8355:LOC108705600
uniprot id: A0A8J1LWG2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:vim.L
gene id: 8355:vim.L
uniprot id: P24789
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Homomer.
messages: One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized.
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

8355:nkx3-2.S
gene id: 8355:nkx3-2.S
uniprot id: P70061
names: Developmental Stage
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NK-3 homeobox family.
messages: By foxf1-B.
messages: First expressed during late neurula stage (stage 18). Levels increase slowly up to the tailbud stage (stage 28), then increase sharply before remaining approximately constant through the remaining tailbud and tadpole stages (stages 30-44).
messages: First expressed in developing facial cartilage in early tailbud embryos, with expression localized to the basihyobranchial, palatoquadrate and possibly Meckel's cartilages. Shortly after, a second area of expression is seen in the musculature of the anterior gut. During late embryogenesis, gut expression extends into hindgut tissues. In adults, expressed at a high level in the kidney, pancreas, spleen and stomach and at a slightly lower level in the intestine, skeletal muscle and tongue. Adult heart, liver and lung show little or no expression.
messages: Nucleus

8355:ncald.L
gene id: 8355:ncald.L
uniprot id: Q7SY75
names: Function
names: Similarity
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).

8355:gsto2.L
gene id: 8355:gsto2.L
uniprot id: A8E5X8
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

8355:ireb2.L
gene id: 8355:ireb2.L
uniprot id: Q6NTP2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit. [4Fe-4S]-binding affects RNA-binding activity, thereby inhibiting activity of the protein.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
messages: Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen.

8355:adra1b.L
gene id: 8355:adra1b.L
uniprot id: A0A8J1MKF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

8355:ahr.L
gene id: 8355:ahr.L
uniprot id: Q4QY31
names: Subcellular Location Annotation
messages: Cytoplasm

8355:dhrs7c.L
gene id: 8355:dhrs7c.L
uniprot id: A0A8J0TLJ8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8355:LOC108704766
gene id: 8355:LOC108704766
uniprot id: A0A8J0U882
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108707349
gene id: 8355:LOC108707349
uniprot id: A0A8J1M5J0
uniprot id: A0A8J1M690
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8355:rad51.S
gene id: 8355:rad51.S
uniprot id: Q91918
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

8355:LOC121396467
gene id: 8355:LOC121396467
uniprot id: A0A8J1LCN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

8355:decr2.L
gene id: 8355:decr2.L
uniprot id: A0A8J0TJC8
uniprot id: Q6GR01
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

8355:retn.2.L
gene id: 8355:retn.2.L
uniprot id: A0A8J0VJW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistin/FIZZ family.
messages: Secreted

8355:LOC108701859
gene id: 8355:LOC108701859
uniprot id: A0A8J1LV45
uniprot id: A0A8J1LWV1
names: Similarity
messages: Belongs to the VPS8 family.

8355:ripk3L.2.L
gene id: 8355:ripk3L.2.L
uniprot id: A0A8J0TDL5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:nasp.S
gene id: 8355:nasp.S
uniprot id: A0A1L8GFM0
uniprot id: P06180
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus
messages: This protein is involved in nucleosome assembly. It is bound to H3 and H4 in the absence of DNA, but released from H3 and H4 in the presence of DNA.

8355:dapk3.L
gene id: 8355:dapk3.L
uniprot id: Q4V808
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108699084
gene id: 8355:LOC108699084
uniprot id: A0A8J0TKN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:tspan3.L
gene id: 8355:tspan3.L
uniprot id: Q4FZN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8355:LOC121396344
gene id: 8355:LOC121396344
uniprot id: A0A8J1LEL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:nxt2.L
gene id: 8355:nxt2.L
uniprot id: Q6PE95
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

8355:vsx2.S
gene id: 8355:vsx2.S
uniprot id: A0A1L8F0U1
uniprot id: A0A8J1LNV2
uniprot id: A0A8J1LNY7
names: Subcellular Location Annotation
messages: Nucleus

8355:mmp15.S
gene id: 8355:mmp15.S
uniprot id: A0A1L8GFA9
uniprot id: A0A8J0V5M3
names: Similarity
messages: Belongs to the peptidase M10A family.

8355:tacr3.S
gene id: 8355:tacr3.S
uniprot id: A0A1L8HM58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:syt16.L
gene id: 8355:syt16.L
uniprot id: A0A8J0TL15
uniprot id: A0A8J0TM10
uniprot id: A0A8J1LK07
names: Similarity
messages: Belongs to the synaptotagmin family.

8355:ovol1.L
gene id: 8355:ovol1.L
uniprot id: A0A1L8GJZ4
uniprot id: A0A8J1MWX1
names: Subcellular Location Annotation
messages: Nucleus

8355:tspan17.L
gene id: 8355:tspan17.L
uniprot id: A0A1L8GXX3
uniprot id: A0A8J0UPA6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:syf2.S
gene id: 8355:syf2.S
uniprot id: A0A8J0VKW9
uniprot id: Q8AVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing as component of the spliceosome.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

8355:LOC108699068
gene id: 8355:LOC108699068
uniprot id: A0A8J0TCV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:ngfr.S
gene id: 8355:ngfr.S
uniprot id: A0A8J0TYV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:sf3b1.L
gene id: 8355:sf3b1.L
uniprot id: A0A8J0TYA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

8355:LOC121398105
gene id: 8355:LOC121398105
uniprot id: A0A8J1LSQ6
names: Subcellular Location Annotation
messages: Nucleus

8355:cops8.S
gene id: 8355:cops8.S
uniprot id: A0A8J0U0M6
uniprot id: Q6GQA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN8 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Nucleus

8355:slc2a12.L
gene id: 8355:slc2a12.L
uniprot id: Q32NG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Insulin-regulated facilitative glucose transporter.
messages: perinuclear region

8355:trappc3l.L
gene id: 8355:trappc3l.L
uniprot id: A0A1L8G8U7
uniprot id: A0A8J0VGH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

8355:marcksl1.S
gene id: 8355:marcksl1.S
uniprot id: A0A1L8H7V3
names: Similarity
messages: Belongs to the MARCKS family.

8355:LOC397693
gene id: 8355:LOC397693
uniprot id: A0A8J1LJM6
uniprot id: A0A8J1LL00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

8355:mcm6.L
gene id: 8355:mcm6.L
uniprot id: Q5FWY4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the mcm2-7 complex (RLF-M) (PubMed:16369567, PubMed:9214646, PubMed:9214647, PubMed:9851868). The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (PubMed:16369567, PubMed:9214646, PubMed:9214647, PubMed:9851868). The heterodimer of mmcm3/mcm5 interacts with mcm4, mmcm6, mcm7 and weakly with mcm2 (PubMed:16369567, PubMed:9214646, PubMed:9214647, PubMed:9851868). Component of the CMG helicase complex, composed of the mcm2-7 complex, the GINS complex and cdc45 (PubMed:30979826, PubMed:30842657).
messages: Expressed maternally. Expressed in the egg and early embryo at a constant level until the gastrula stage, declining drastically at the neurula stage.
messages: Nucleus

8355:LOC121399000
gene id: 8355:LOC121399000
uniprot id: A0A8J1M034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:tm4sf5.S
gene id: 8355:tm4sf5.S
uniprot id: A9JS23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

8355:LOC108710534
gene id: 8355:LOC108710534
uniprot id: A0A1L8H4S1
names: Subcellular Location Annotation
messages: Membrane

8355:XB5993457.L
gene id: 8355:XB5993457.L
uniprot id: A0A8J1KYR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

8355:LOC108695637
gene id: 8355:LOC108695637
uniprot id: A0A8J0SZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:alg6.S
gene id: 8355:alg6.S
uniprot id: A0A8J1N1E4
uniprot id: Q6DDK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC121401324
gene id: 8355:LOC121401324
uniprot id: A0A1L8H413
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108714034
gene id: 8355:LOC108714034
uniprot id: A0A1L8GKT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

8355:LOC108715031
gene id: 8355:LOC108715031
uniprot id: A0A1L8GHE2
uniprot id: A0A8J0V513
names: Similarity
messages: Belongs to the Speedy/Ringo family.

8355:nefh.L
gene id: 8355:nefh.L
uniprot id: A0A1L8HZT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon
messages: cytoskeleton

8355:LOC108704214
gene id: 8355:LOC108704214
uniprot id: A0A8J0U6V3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

8355:LOC108716491
gene id: 8355:LOC108716491
uniprot id: A0A1L8G6T0
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

8355:ins.S
gene id: 8355:ins.S
uniprot id: A0A1L8GD41
uniprot id: P12706
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

8355:gfm2.L
gene id: 8355:gfm2.L
uniprot id: A0A1L8I2R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

8355:lrrc8b.L
gene id: 8355:lrrc8b.L
uniprot id: A0A1L8GMZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8355:akirin1.L
gene id: 8355:akirin1.L
uniprot id: Q7ZY70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development. Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis.
messages: Nucleus

8355:hebp1.L
gene id: 8355:hebp1.L
uniprot id: Q6NU05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEBP family.
messages: Cytoplasm
messages: Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure (By similarity).
messages: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity).
messages: Monomer.

8355:susd3.L
gene id: 8355:susd3.L
uniprot id: A0A8J0U3N5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:slc25a40.L
gene id: 8355:slc25a40.L
uniprot id: A0A8J1KVR0
uniprot id: Q6DFK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters (By similarity).

8355:isoc1.S
gene id: 8355:isoc1.S
uniprot id: A0A310U6Q4
names: Similarity
messages: Belongs to the isochorismatase family.

8355:glmp.L
gene id: 8355:glmp.L
uniprot id: A0A1L8FCZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLMP family.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

8355:LOC121400938
gene id: 8355:LOC121400938
uniprot id: A0A8J1MGY5
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108715635
gene id: 8355:LOC108715635
uniprot id: A0A1L8GG25
uniprot id: A0A8J0V7Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

8355:LOC108710673
gene id: 8355:LOC108710673
uniprot id: A0A1L8H4F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108703274
gene id: 8355:LOC108703274
uniprot id: A0A8J0U2S0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:nfx1.S
gene id: 8355:nfx1.S
uniprot id: A0A1L8FS02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

8355:ube4a.L
gene id: 8355:ube4a.L
uniprot id: A0A1L8FLJ3
uniprot id: A0A8J0T8Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

8355:kcnk16.L
gene id: 8355:kcnk16.L
uniprot id: A0A1L8G6M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

8355:htr7.S
gene id: 8355:htr7.S
uniprot id: A0A1L8FEU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:MGC64368
gene id: 8355:MGC64368
uniprot id: A0A1L8ET11
uniprot id: Q7SYZ7
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

8355:LOC108709047
gene id: 8355:LOC108709047
uniprot id: A0A8J0UAU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fat3.S
gene id: 8355:fat3.S
uniprot id: A0A8J0UMC9
uniprot id: A0A8J0UQB7
uniprot id: A0A8J1MFM3
uniprot id: A0A8J1MGK5
uniprot id: A0A8J1MHG2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:mindy1.S
gene id: 8355:mindy1.S
uniprot id: A0A1L8F4Q2
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

8355:septin2.S
gene id: 8355:septin2.S
uniprot id: A0A1L8G4K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium membrane
messages: spindle

8355:selenoo.L
gene id: 8355:selenoo.L
uniprot id: A0A8J0QH16
names: Similarity
messages: Belongs to the SELO family.

8355:hcrtr2.L
gene id: 8355:hcrtr2.L
uniprot id: A0A1L8G9N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108715054
gene id: 8355:LOC108715054
uniprot id: A0A8J1KKD2
names: Similarity
messages: Belongs to the filamin family.

8355:LOC108716810
gene id: 8355:LOC108716810
uniprot id: A0A1L8G9B9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:tmem184a.L
gene id: 8355:tmem184a.L
uniprot id: A0A1L8EXX6
names: Subcellular Location Annotation
messages: Membrane

8355:adamts8.L
gene id: 8355:adamts8.L
uniprot id: A0A1L8FL27
uniprot id: A0A8J0T8E1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

8355:LOC108717597
gene id: 8355:LOC108717597
uniprot id: A0A1L8G536
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

8355:LOC121401458
gene id: 8355:LOC121401458
uniprot id: A0A8J1MK06
names: Subcellular Location Annotation
messages: Membrane

8355:e2f5.L
gene id: 8355:e2f5.L
uniprot id: A0A1L8FZF3
uniprot id: A0A8J0VLD5
uniprot id: A0A8J0VPD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8355:ints3.S
gene id: 8355:ints3.S
uniprot id: A0A8J1LLS4
uniprot id: A0A8J1LLY7
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

8355:LOC108700150
gene id: 8355:LOC108700150
uniprot id: A0A1L8F381
uniprot id: A0A8J0TNK1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

8355:LOC121393379
gene id: 8355:LOC121393379
uniprot id: A0A1L8GI59
uniprot id: A0A8J1KLW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

8355:cxcr6.L
gene id: 8355:cxcr6.L
uniprot id: A0A8J1KXT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

8355:camk1d.S
gene id: 8355:camk1d.S
uniprot id: Q8AYR3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:atpaf1.S
gene id: 8355:atpaf1.S
uniprot id: A0A1L8GFS6
uniprot id: A0A8J1KJA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

8355:znf592.S
gene id: 8355:znf592.S
uniprot id: A0A1L8GTH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

8355:tcea3.L
gene id: 8355:tcea3.L
uniprot id: A0A8J1M838
uniprot id: A0A8J1M959
uniprot id: A0A8J1M9X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

8355:LOC108697793
gene id: 8355:LOC108697793
uniprot id: A0A1L8FH34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

8355:hpf1.L
gene id: 8355:hpf1.L
uniprot id: A0A1L8HU84
names: Similarity
messages: Belongs to the HPF1 family.

8355:LOC108720060
gene id: 8355:LOC108720060
uniprot id: A0A1L8FS62
uniprot id: A0A8J1L2A0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

8355:tulp4.L
gene id: 8355:tulp4.L
uniprot id: A0A8J0VAJ5
names: Similarity
messages: Belongs to the TUB family.

8355:LOC108699033
gene id: 8355:LOC108699033
uniprot id: A0A8J0TMD4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:kpna2.L
gene id: 8355:kpna2.L
uniprot id: Q7ZYI0
names: Similarity
messages: Belongs to the importin alpha family.

8355:sptlc3.S
gene id: 8355:sptlc3.S
uniprot id: Q2TAS1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

8355:slc7a14.S
gene id: 8355:slc7a14.S
uniprot id: A0A310TMS3
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108712451
gene id: 8355:LOC108712451
uniprot id: A0A8J1MRE6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:crisp1.8.L
gene id: 8355:crisp1.8.L
uniprot id: A0A8J0VAC6
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:hdac9.L
gene id: 8355:hdac9.L
uniprot id: A0A1L8FVZ4
uniprot id: A0A8J0VNN1
uniprot id: A0A8J1KYT8
uniprot id: A0A8J1L043
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus

8355:rpl31.L
gene id: 8355:rpl31.L
uniprot id: Q6NUH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8355:LOC108717244
gene id: 8355:LOC108717244
uniprot id: A0A8J0VDX5
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108714294
gene id: 8355:LOC108714294
uniprot id: A0A8J0V6C5
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:prok2.S
gene id: 8355:prok2.S
uniprot id: A2RVB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

8355:scn1b.S
gene id: 8355:scn1b.S
uniprot id: A0A8J0T7R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon

8355:LOC108716637
gene id: 8355:LOC108716637
uniprot id: A0A8J0VA53
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108715298
gene id: 8355:LOC108715298
uniprot id: A0A1L8GDV9
uniprot id: A0A8J0V1C6
uniprot id: A0A8J0V6D5
uniprot id: A0A8J1KHX8
uniprot id: A0A8J1KL52
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:rab18.S
gene id: 8355:rab18.S
uniprot id: Q6GM52
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

8355:aox1.L
gene id: 8355:aox1.L
uniprot id: A0A8J0TV29
uniprot id: A0A8J1LRM0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

8355:art1.S
gene id: 8355:art1.S
uniprot id: A0A1L8HBK9
uniprot id: A0A8J1MFX6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

8355:ccny.L
gene id: 8355:ccny.L
uniprot id: A0A1L8FVD2
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

8355:tmem178a.L
gene id: 8355:tmem178a.L
uniprot id: A0A1L8G7H9
names: Similarity
messages: Belongs to the TMEM178 family.

8355:synj2.L
gene id: 8355:synj2.L
uniprot id: A0A1L8G8G7
uniprot id: A0A8J0VAJ0
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

8355:cdk11b.S
gene id: 8355:cdk11b.S
uniprot id: A0A1L8FG75
uniprot id: A0A8J0TB01
uniprot id: A0A8J0TD03
uniprot id: A0A8J0TD07
uniprot id: A0A8J0TDP5
uniprot id: A0A8J0TED5
uniprot id: Q6DE25
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

8355:LOC121399294
gene id: 8355:LOC121399294
uniprot id: A0A8J1M1A5
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:ccdc69.L
gene id: 8355:ccdc69.L
uniprot id: Q08AV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC69 family.
messages: May act as a scaffold to regulate the recruitment and assembly of spindle midzone components.
messages: Midbody
messages: spindle

8355:setd1b.S
gene id: 8355:setd1b.S
uniprot id: A0A8J0TYJ2
uniprot id: A0A8J0TZS2
uniprot id: A0A8J1LSI1
uniprot id: Q66J90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
messages: Nucleus speckle

8355:cdhr1.L
gene id: 8355:cdhr1.L
uniprot id: Q6B457
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in photoreceptor cells of the outer nuclear layer of the retina and in the pinal gland.
messages: Expressed in the retina 3 days post-fertilization (hpf).
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein.

8355:LOC108709309
gene id: 8355:LOC108709309
uniprot id: A0A8J0UBM6
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

8355:LOC108695428
gene id: 8355:LOC108695428
uniprot id: A0A1L8HY03
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:hsf2.L
gene id: 8355:hsf2.L
uniprot id: A0A8J1KLP0
uniprot id: A0A8J1KLP7
uniprot id: A0A8J1KLR2
uniprot id: Q5EG56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8355:stoml3.L
gene id: 8355:stoml3.L
uniprot id: Q3KQ81
names: Similarity
messages: Belongs to the band 7/mec-2 family.

8355:LOC108697184
gene id: 8355:LOC108697184
uniprot id: A0A8J0TE13
names: Subcellular Location Annotation
messages: Nucleus

8355:phactr3.L
gene id: 8355:phactr3.L
uniprot id: A0A1L8ESY6
uniprot id: A0A8J0TRT3
uniprot id: Q32NG1
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

8355:KEF37 p04
gene id: 8355:KEF37_p04
uniprot id: P03912
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion membrane

8355:LOC121403742
gene id: 8355:LOC121403742
uniprot id: A0A8J1N027
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

8355:kif5c.S
gene id: 8355:kif5c.S
uniprot id: A0A1L8EP18
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:LOC108700497
gene id: 8355:LOC108700497
uniprot id: A0A8J1LR06
names: Similarity
messages: Belongs to the CDC26 family.

8355:aldoa.S
gene id: 8355:aldoa.S
uniprot id: O12975
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

8355:cyp2c8.1.L
gene id: 8355:cyp2c8.1.L
uniprot id: A0A1L8FB58
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:LOC108719747
gene id: 8355:LOC108719747
uniprot id: A0A1L8FTN5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:sec62.L
gene id: 8355:sec62.L
uniprot id: A0A8J0V8G3
uniprot id: Q6AZP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:e2f4.L
gene id: 8355:e2f4.L
uniprot id: A0A1L8GLJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

8355:anxa13.S
gene id: 8355:anxa13.S
uniprot id: A0A1L8FTY3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

8355:LOC108700607
gene id: 8355:LOC108700607
uniprot id: A0A8J1LP02
names: Similarity
messages: Belongs to the MHC class I family.

8355:egr3.L
gene id: 8355:egr3.L
uniprot id: A0A1L8H235
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

8355:emx1l.S
gene id: 8355:emx1l.S
uniprot id: A0A1L8GV07
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121403015
gene id: 8355:LOC121403015
uniprot id: A0A1L8GKV8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:sat1.L
gene id: 8355:sat1.L
uniprot id: A0A8J1M5K9
uniprot id: Q68F31
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Homodimer.

8355:gapvd1.S
gene id: 8355:gapvd1.S
uniprot id: A0A8J1LK41
uniprot id: A0A8J1LK46
uniprot id: A0A8J1LKA2
uniprot id: A0A8J1LKA6
uniprot id: A0A8J1LKB2
uniprot id: A0A8J1LL02
uniprot id: A0A8J1LL06
uniprot id: A0A8J1LLD5
uniprot id: A0A8J1LLE0
uniprot id: A0A8J1LMJ8
uniprot id: A0A8J1LMK4
uniprot id: A2RV61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking.
messages: Belongs to the GAPVD1 family.
messages: Endosome
messages: Membrane

8355:sesn2.L
gene id: 8355:sesn2.L
uniprot id: A0A8J0U3P7
uniprot id: A0A8J1M5A2
uniprot id: Q6NU55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

8355:slbp.L
gene id: 8355:slbp.L
uniprot id: P79943
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SLBP family.
messages: Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3' end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP) (PubMed:8957003, PubMed:9858606). Could play an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (By similarity).
messages: Cytoplasm
messages: Interacts with mif4gd.
messages: Nucleus
messages: Phosphorylated on Thr-60 during mitosis.
messages: Very low levels in stage I oocytes, gradually increasing throughout oogenesis. Further increase is achieved during early embryogenesis.
messages: Widely expressed.

8355:slc5a12.L
gene id: 8355:slc5a12.L
uniprot id: A0A1L8GJF7
uniprot id: A0A8J0UZM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8355:ubn2.S
gene id: 8355:ubn2.S
uniprot id: A0A1L8GGN9
uniprot id: A0A8J0V6P9
names: Similarity
messages: Belongs to the ubinuclein family.

8355:bbs2.S
gene id: 8355:bbs2.S
uniprot id: A0A8J0V1L9
uniprot id: A0A8J0V622
uniprot id: A0A8J1KK12
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

8355:cstf1.S
gene id: 8355:cstf1.S
uniprot id: Q7ZYG2
names: Subcellular Location Annotation
messages: Nucleus

8355:slc34a3.S
gene id: 8355:slc34a3.S
uniprot id: A0A1L8F0N8
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

8355:tgif2.L
gene id: 8355:tgif2.L
uniprot id: A0A8J0U4E6
uniprot id: Q66J83
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC121393950
gene id: 8355:LOC121393950
uniprot id: A0A8J1KQC5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:LOC108718508
gene id: 8355:LOC108718508
uniprot id: A0A1L8FX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8355:myh9.L
gene id: 8355:myh9.L
uniprot id: O93522
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:LOC121393925
gene id: 8355:LOC121393925
uniprot id: A0A8J1KSH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

8355:arrb1.L
gene id: 8355:arrb1.L
uniprot id: A0A8J1MAI6
uniprot id: A0A8J1MAV0
uniprot id: A0A8J1MBI9
names: Similarity
messages: Belongs to the arrestin family.

8355:sult6b1.5.S
gene id: 8355:sult6b1.5.S
uniprot id: A0A8J1KST5
uniprot id: Q3KPL6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:sgf29.L
gene id: 8355:sgf29.L
uniprot id: A0A8J0TWD3
uniprot id: A0A8J1LVH1
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108702495
gene id: 8355:LOC108702495
uniprot id: A0A1L8EKQ1
uniprot id: A0A8J1M142
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

8355:LOC121397903
gene id: 8355:LOC121397903
uniprot id: A0A8J1LR62
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC108713565
gene id: 8355:LOC108713565
uniprot id: A0A1L8GP20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane

8355:tubgcp4.S
gene id: 8355:tubgcp4.S
uniprot id: A0A1L8GSP7
uniprot id: A0A8J1MR16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

8355:p2rx5.S
gene id: 8355:p2rx5.S
uniprot id: A0A1L8H4Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

8355:dst.L
gene id: 8355:dst.L
uniprot id: A0A8J0V8D1
uniprot id: A0A8J0V8D6
uniprot id: A0A8J0VBC2
uniprot id: A0A8J0VBC7
uniprot id: A0A8J0VBV4
uniprot id: A0A8J0VBW0
uniprot id: A0A8J0VCM6
uniprot id: A0A8J1KP55
uniprot id: A0A8J1KP61
uniprot id: A0A8J1KP65
uniprot id: A0A8J1KP66
uniprot id: A0A8J1KP68
uniprot id: A0A8J1KP70
uniprot id: A0A8J1KP71
uniprot id: A0A8J1KQT8
uniprot id: A0A8J1KQU3
uniprot id: A0A8J1KSA5
uniprot id: A0A8J1KSB3
names: Subcellular Location Annotation
messages: cytoskeleton

8355:sptbn5.L
gene id: 8355:sptbn5.L
uniprot id: A0A1L8FAE8
names: Similarity
messages: Belongs to the spectrin family.

8355:LOC108700662
gene id: 8355:LOC108700662
uniprot id: A0A1L8F382
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

8355:LOC108717228
gene id: 8355:LOC108717228
uniprot id: A0A1L8GC81
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:atad2b.S
gene id: 8355:atad2b.S
uniprot id: A0A8J1KUL1
uniprot id: A0A8J1KW60
uniprot id: A0A8J1KXM1
names: Similarity
messages: Belongs to the AAA ATPase family.

8355:cacng4.L
gene id: 8355:cacng4.L
uniprot id: A0A1L8EUY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

8355:gng4.S
gene id: 8355:gng4.S
uniprot id: Q6AZS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8355:jade3.S
gene id: 8355:jade3.S
uniprot id: A0A8J1MBB0
uniprot id: A0A8J1MC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

8355:LOC108716761
gene id: 8355:LOC108716761
uniprot id: A0A1L8G8F3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

8355:LOC121395588
gene id: 8355:LOC121395588
uniprot id: A0A8J1L719
uniprot id: A0A8J1L729
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

8355:ccdc78.S
gene id: 8355:ccdc78.S
uniprot id: Q66KE8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CCDC78 family.
messages: Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for cep152 localization to the deuterosome.
messages: Highly up-regulated in the ciliated epithelia of embryonic skin during the developmental window of centriole biogenesis. Expression is probably activated by mcidas/mcin.
messages: Restricted to multiciliated cells.
messages: centriole

8355:polr2j.S
gene id: 8355:polr2j.S
uniprot id: Q5M778
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

8355:slc6a8l.S
gene id: 8355:slc6a8l.S
uniprot id: A0A8J0V7D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:actr2.L
gene id: 8355:actr2.L
uniprot id: Q7ZXV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: Belongs to the actin family. ARP2 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
messages: Nucleus
messages: cytoskeleton

8355:slc15a5.L
gene id: 8355:slc15a5.L
uniprot id: A0A1L8GVV5
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

8355:LOC108714333
gene id: 8355:LOC108714333
uniprot id: A0A1L8GMH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

8355:LOC108710493
gene id: 8355:LOC108710493
uniprot id: A0A1L8H417
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108716895
gene id: 8355:LOC108716895
uniprot id: A0A1L8G9H5
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

8355:LOC108705286
gene id: 8355:LOC108705286
uniprot id: A0A8J1LYU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:LOC108701898
gene id: 8355:LOC108701898
uniprot id: A0A8J1LRD0
uniprot id: A0A8J1LSY8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

8355:tubz1.L
gene id: 8355:tubz1.L
uniprot id: A0A8J1KVB1
uniprot id: Q8AVA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

8355:gfra4.S
gene id: 8355:gfra4.S
uniprot id: A0A1L8HKG7
names: Similarity
messages: Belongs to the GDNFR family.

8355:ufm1.L
gene id: 8355:ufm1.L
uniprot id: Q5RJW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UFM1 family.
messages: Cytoplasm
messages: Interacts with uba5. Interacts with ufc1.
messages: Nucleus
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the ufm1-activating E1 enzyme uba5, the ufm1-conjugating E2 enzyme ufc1, and the ufm1-ligase E3 enzyme ufl1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

8355:LOC108709451
gene id: 8355:LOC108709451
uniprot id: A0A8J0UK56
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

8355:LOC108718108
gene id: 8355:LOC108718108
uniprot id: A0A8J1KU57
uniprot id: A0A8J1KX57
names: Subcellular Location Annotation
messages: Membrane

8355:ccno.L
gene id: 8355:ccno.L
uniprot id: Q32NJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: Cytoplasm
messages: Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of mcidas to promote mother centriole amplification and maturation in preparation for apical docking.

8355:cat.2.S
gene id: 8355:cat.2.S
uniprot id: A0A1L8GDM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

8355:tysnd1.L
gene id: 8355:tysnd1.L
uniprot id: A0A1L8FJW0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

8355:b4galt3l2.S
gene id: 8355:b4galt3l2.S
uniprot id: A0A8J1LAB8
uniprot id: Q6DDG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:wnt7c.S
gene id: 8355:wnt7c.S
uniprot id: A0A1L8F1K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:LOC121399688
gene id: 8355:LOC121399688
uniprot id: A0A8J1M7Y0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:ca7.S
gene id: 8355:ca7.S
uniprot id: A0A8J0U3A5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8355:selenot.S
gene id: 8355:selenot.S
uniprot id: A0A8J0PNL7
names: Similarity
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.

8355:mrs2.L
gene id: 8355:mrs2.L
uniprot id: A0A1L8FY76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

8355:tmed6.L
gene id: 8355:tmed6.L
uniprot id: A0A1L8GKY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:krt78.8.L
gene id: 8355:krt78.8.L
uniprot id: A0A8J0UGT2
names: Similarity
messages: Belongs to the intermediate filament family.

8355:tmod4.S
gene id: 8355:tmod4.S
uniprot id: A0A1L8F4N2
names: Subcellular Location Annotation
messages: cytoskeleton

8355:tmtc1.L
gene id: 8355:tmtc1.L
uniprot id: A0A1L8GW98
uniprot id: A0A8J1MJM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

8355:pck1.L
gene id: 8355:pck1.L
uniprot id: Q7ZWK0
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

8355:vps37a.S
gene id: 8355:vps37a.S
uniprot id: A0A8J1LER8
uniprot id: A1L2J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

8355:LOC108705634
gene id: 8355:LOC108705634
uniprot id: A0A8J1LDS4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8355:paqr3.L
gene id: 8355:paqr3.L
uniprot id: A0A1L8HWC0
uniprot id: Q6GLM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8355:LOC108711672
gene id: 8355:LOC108711672
uniprot id: A0A8J0ULB0
uniprot id: A0A8J1MZL9
uniprot id: A0A8J1MZM8
uniprot id: A0A8J1MZQ4
uniprot id: A0A8J1MZQ9
uniprot id: A0A8J1MZW5
uniprot id: A0A8J1MZZ2
uniprot id: A0A8J1N002
uniprot id: A0A8J1N018
uniprot id: A0A8J1N028
uniprot id: A0A8J1N0T5
uniprot id: A0A8J1N1M1
uniprot id: A0A8J1N1P9
uniprot id: A0A8J1N2C9
uniprot id: A0A8J1N2D4
uniprot id: A0A8J1N2F7
uniprot id: A0A8J1N2I1
uniprot id: A0A8J1N2J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:eef1d.S
gene id: 8355:eef1d.S
uniprot id: A0A8J0VIP8
uniprot id: A0A8J0VKZ2
uniprot id: A0A8J0VL72
uniprot id: A0A8J0VM42
uniprot id: A0A8J0VPT2
uniprot id: P29693
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

8355:esrp1.L
gene id: 8355:esrp1.L
uniprot id: A0A8J0VH46
uniprot id: A0A8J0VMF6
uniprot id: Q7ZY29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus
messages: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity).

8355:sntg2.S
gene id: 8355:sntg2.S
uniprot id: A0A8J1KUG4
uniprot id: A0A8J1KW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

8355:med6.L
gene id: 8355:med6.L
uniprot id: A0A1L8FAJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8355:slc14a2.L
gene id: 8355:slc14a2.L
uniprot id: A0A1L8I3M4
uniprot id: A0A8J1LB43
uniprot id: A0A8J1LC20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

8355:LOC121395374
gene id: 8355:LOC121395374
uniprot id: A0A8J1L575
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

8355:LOC121397985
gene id: 8355:LOC121397985
uniprot id: A0A8J1LRQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sdf4.S
gene id: 8355:sdf4.S
uniprot id: A0A1L8FG93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

8355:stx6.L
gene id: 8355:stx6.L
uniprot id: Q6IP43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

8355:psme3.L
gene id: 8355:psme3.L
uniprot id: A0A8J0TJ77
uniprot id: A0A8J0TRT8
uniprot id: A0A8J0TSW7
uniprot id: A0A8J1LPK1
uniprot id: A0A8J1LQH6
uniprot id: Q6NTV2
names: Similarity
messages: Belongs to the PA28 family.

8355:foxn1.S
gene id: 8355:foxn1.S
uniprot id: A0A8J0UJ13
uniprot id: A0A8J0UJ57
uniprot id: A0A8J1MDU7
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108704587
gene id: 8355:LOC108704587
uniprot id: A0A8J1KM42
names: Subcellular Location Annotation
messages: Cytoplasm

8355:grin2b.L
gene id: 8355:grin2b.L
uniprot id: A0A1L8GND5
uniprot id: A9QW73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

8355:olfml3.L
gene id: 8355:olfml3.L
uniprot id: B5MFE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OLFML3 family.
messages: Interacts (via coiled coil domain) with BMP1 and (via olfactomedin-like domain) CHRD.
messages: Secreted
messages: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid protease BMP1 and its substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation by BMP1.

8355:strbp.L
gene id: 8355:strbp.L
uniprot id: Q6DCD0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis and sperm function. Binds to double-stranded DNA and RNA (By similarity).

8355:timm10.L
gene id: 8355:timm10.L
uniprot id: Q6GQ52
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

8355:LOC108697455
gene id: 8355:LOC108697455
uniprot id: A0A8J0TDZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8355:pgr.L
gene id: 8355:pgr.L
uniprot id: A0A8J1M6S8
uniprot id: Q9DDU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8355:itpripl2.L
gene id: 8355:itpripl2.L
uniprot id: A0A1L8EXN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Belongs to the mab-21 family.
messages: Membrane

8355:pitpnm3.S
gene id: 8355:pitpnm3.S
uniprot id: A0A8J1MD51
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

8355:mrpl32.L
gene id: 8355:mrpl32.L
uniprot id: A7YYL7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

8355:LOC108714493
gene id: 8355:LOC108714493
uniprot id: A0A1L8GNK8
names: Similarity
messages: Belongs to the janus family.

8355:ripor2.S
gene id: 8355:ripor2.S
uniprot id: A0A1L8FSG7
uniprot id: A0A8J0VKA8
uniprot id: A0A8J0VMJ9
uniprot id: A0A8J1L2D5
uniprot id: A0A8J1L401
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: stereocilium membrane

8355:fis1.S
gene id: 8355:fis1.S
uniprot id: A0A8J1MSV1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

8355:LOC108719340
gene id: 8355:LOC108719340
uniprot id: A0A1L8FZI3
names: Similarity
messages: Belongs to the GSK-3-binding protein family.

8355:LOC121395427
gene id: 8355:LOC121395427
uniprot id: A0A8J1L8H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

8355:pmp2.L
gene id: 8355:pmp2.L
uniprot id: Q6P705
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8355:asah1.L
gene id: 8355:asah1.L
uniprot id: Q68F24
names: Similarity
messages: Belongs to the acid ceramidase family.

8355:thrsp.L
gene id: 8355:thrsp.L
uniprot id: A0A1L8F7H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

8355:XB5856184.L
gene id: 8355:XB5856184.L
uniprot id: A0A1L8FBP2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:hoxb6.L
gene id: 8355:hoxb6.L
uniprot id: A0A1L8ES26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

8355:LOC121393259
gene id: 8355:LOC121393259
uniprot id: A0A8J1KIE6
uniprot id: A0A8J1KIG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

8355:gsg1.L
gene id: 8355:gsg1.L
uniprot id: A0A8J0V369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

8355:pam16.L
gene id: 8355:pam16.L
uniprot id: Q6NTU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM16/PAM16 family.
messages: Mitochondrion inner membrane
messages: Probable component of the PAM complex at least composed of 1 mitochondrial HSP70 protein, 1 GRPE, 1 TIMM44, 1 TIMM16/PAM16 and 1 TIMM14. Associates with the TIM23 complex.
messages: Regulates ATP-dependent protein translocation into the mitochondrial matrix.
messages: The J-like region, although related to the J domain does not have co-chaperone activity.

8355:smad9.S
gene id: 8355:smad9.S
uniprot id: Q6PF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8355:LOC108706726
gene id: 8355:LOC108706726
uniprot id: A0A8J0U0G6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

8355:LOC495407
gene id: 8355:LOC495407
uniprot id: Q5U4Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.

8355:LOC121393616
gene id: 8355:LOC121393616
uniprot id: A0A1L8G0S2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:LOC108700332
gene id: 8355:LOC108700332
uniprot id: A0A8J1LLB9
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:ncbp1.S
gene id: 8355:ncbp1.S
uniprot id: Q6GQD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NCBP1 family.
messages: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. The conventional CBC with NCBP2 binds both small nucle…
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA. Component of an alternative nuclear cap-binding complex (CBC) composed of ncbp1/cbp80 and ncbp3 (By similarity).
messages: Cytoplasm
messages: Nucleus

8355:vegfc.S
gene id: 8355:vegfc.S
uniprot id: Q5EAW1
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

8355:uckl1.L
gene id: 8355:uckl1.L
uniprot id: A0A8J1KLM3
uniprot id: A0A8J1KLN0
uniprot id: A0A8J1KPQ4
uniprot id: Q5M7E4
names: Similarity
messages: Belongs to the uridine kinase family.

8355:stoml2.S
gene id: 8355:stoml2.S
uniprot id: A0A8J1M6D2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

8355:en1.L
gene id: 8355:en1.L
uniprot id: Q3KQ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

8355:LOC121393236
gene id: 8355:LOC121393236
uniprot id: A0A8J1KI99
names: Similarity
messages: Belongs to the cyclin family.

8355:nmt1.L
gene id: 8355:nmt1.L
uniprot id: Q7ZYT2
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

8355:LOC121400433
gene id: 8355:LOC121400433
uniprot id: A0A8J1MD39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:tnpo2.L
gene id: 8355:tnpo2.L
uniprot id: A0A8J0UG17
uniprot id: Q5U4R8
names: Subcellular Location Annotation
messages: Cytoplasm

8355:lcorl.S
gene id: 8355:lcorl.S
uniprot id: A0A8J0U878
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108719486
gene id: 8355:LOC108719486
uniprot id: A0A1L8G0H5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:tet3.S
gene id: 8355:tet3.S
uniprot id: A0A1L8GSA2
uniprot id: A0A8J0UW40
uniprot id: A0A8J0UZR6
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Binds target DNA that contains at least one unmethylated cytosine via the CXXC-type zinc-finger domain.
messages: Chromosome
messages: Detected in embryo (at protein level). Detected in embryonic head, in developing brain, neural tube and eye.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not require its enzyme activity.
messages: Expression in oocytes is very low. Barely detectable from stage 2 (2-cell stage) to stage 9. Increases strongly from stage 9 to 17, and decreases again at stage 25.
messages: Morpholino knockdown of both tet3-a and tet3-b causes defects in embryonic development, including malformations of the eye (eyeless), small head, and missing pigmentation along the lateral body, leading to embryonic death between stages 35 and 40.
messages: Nucleus
messages: The zinc ions have a structural role.

8355:atp1b2.S
gene id: 8355:atp1b2.S
uniprot id: A0A8J0U4Y0
uniprot id: Q6GLX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

8355:LOC108699569
gene id: 8355:LOC108699569
uniprot id: A0A1L8FBP5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:chmp5.S
gene id: 8355:chmp5.S
uniprot id: Q8AVR6
names: Similarity
messages: Belongs to the SNF7 family.

8355:MGC83206
gene id: 8355:MGC83206
uniprot id: A0A8J1MQ58
uniprot id: Q6INE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

8355:LOC108697977
gene id: 8355:LOC108697977
uniprot id: A0A1L8FGM0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

8355:cyp26c1.S
gene id: 8355:cyp26c1.S
uniprot id: A0A1L8FED5
uniprot id: A0A8J1LAH3
uniprot id: Q2T9K4
names: Similarity
messages: Belongs to the cytochrome P450 family.

8355:prdm15.S
gene id: 8355:prdm15.S
uniprot id: A0A1L8H5F4
uniprot id: A0A8J0UBE5
uniprot id: A0A8J0UI35
uniprot id: A0A8J0UJD0
uniprot id: A0A8J0UJG1
uniprot id: A0A8J0UM82
uniprot id: A0A8J0UM87
uniprot id: A0A8J1MCD3
names: Subcellular Location Annotation
messages: Nucleus

8355:glul-like.1.L
gene id: 8355:glul-like.1.L
uniprot id: Q6INY0
names: Similarity
messages: Belongs to the glutamine synthetase family.

8355:LOC108701952
gene id: 8355:LOC108701952
uniprot id: A0A1L8EZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:pdf.S
gene id: 8355:pdf.S
uniprot id: A9UM23
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

8355:hkdc1.S
gene id: 8355:hkdc1.S
uniprot id: A0A1L8GS61
names: Similarity
messages: Belongs to the hexokinase family.

8355:steap3.L
gene id: 8355:steap3.L
uniprot id: A0A1L8EV53
uniprot id: A0A8J0TUG5
uniprot id: A0A8J0TWZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

8355:LOC108708229
gene id: 8355:LOC108708229
uniprot id: A0A8J0UF14
names: Similarity
messages: Belongs to the syntaxin family.

8355:LOC108702442
gene id: 8355:LOC108702442
uniprot id: A0A8J0TYJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

8355:LOC108713959
gene id: 8355:LOC108713959
uniprot id: A0A8J0V4Y3
uniprot id: A0A8J1MVT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

8355:ncln.L
gene id: 8355:ncln.L
uniprot id: A0A1L8HXX6
uniprot id: Q6GQK1
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

8355:keap1.L
gene id: 8355:keap1.L
uniprot id: Q5HZR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

8355:slc25a13.S
gene id: 8355:slc25a13.S
uniprot id: A0A8J0VMR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

8355:wnt8a.S
gene id: 8355:wnt8a.S
uniprot id: A0A1L8GVI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:f13b.L
gene id: 8355:f13b.L
uniprot id: A0A1L8GN92
uniprot id: A0A8J0V2S5
uniprot id: A0A8J1MXP5
uniprot id: A0A8J1MZ57
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:lmod1.S
gene id: 8355:lmod1.S
uniprot id: A0A1L8H765
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

8355:sox9.S
gene id: 8355:sox9.S
uniprot id: B7ZR65
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Expressed from mid-gastrula (around stage 10.5) and persists at least through to tadpoles (stage 41).
messages: From mid-gastrula (stage 10.5-11), expressed in a ring around the blastopore, with expression decreasing toward the dorsal side. At stage 12, expression around the blastopore decreases and begins to increase lateral to the neural plate in the presumptive neural crest, where expression dramatically increases around stage 14. Also expressed in the otic placode as early as stage 13/14. By the tailbud stage expression is restricted to the otic cup and then throughout the otic vesicle, with more intense staining at the dorsal-most region, the prospective region of the semicircular canals and endolymphatic duct. At the early tailbud stage (stage 23), expressed in migrating cranial neural crest cells and in the trunk neural crest. Also expressed in the genital ridges, developing eye, nasal placode and prospective pineal gland. Around stage 25, expression is down-regulated in the trunk neural crest but persists in the migrating cranial crest cells as they populate the pharyngeal arches, otic placode, developing eye, genital ridges and notochord. By stage 31, expression remains strong in the pharyngeal arches. Also expressed in the pancreas; first expressed at stage 25 in the pancreatic anlagen, dorsally in diverticulum. As development proceeds, expression continues in pancreatic tissue, being restricted to ventral and dorsal pancreatic buds.
messages: Interacts with the sumoylation factors ube2i/ubc9 and sumo1.
messages: Loss of neural crest progenitors and an expansion of the neural plate, leading to loss or reduction of neural crest-derived skeletal elements later during development.
messages: Nucleus
messages: Sumoylated. Lys-365 is the major site of sumoylation, although sumoylation at Lys-61 also occurs. Sumoylation plays a key role in regulating formation of the neural crest and otic placode.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (By similarity). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1 (By similarity). Plays a central role in successive steps of chondrocyte differentiation (By similarity). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells (By similarity). Involved in development of the cranial neural crest, which is fated to form skeletal elements (PubMed:11807034, PubMed:12812785, PubMed:15464575, PubMed:16256735, PubMed:16943273). Also required for otic placode specification during inner ear development (PubMed:15084460).

8355:LOC108704544
gene id: 8355:LOC108704544
uniprot id: A0A8J0TX24
names: Subcellular Location Annotation
messages: Membrane

8355:tmed5.S
gene id: 8355:tmed5.S
uniprot id: A0A1L8GG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

8355:LOC121400931
gene id: 8355:LOC121400931
uniprot id: A0A8J1MHM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:exosc9.L
gene id: 8355:exosc9.L
uniprot id: Q6GQJ3
names: Subcellular Location Annotation
messages: Cytoplasm

8355:pxn.S
gene id: 8355:pxn.S
uniprot id: A0A8J1LIT0
uniprot id: A0A8J1LJL8
uniprot id: Q9DDK9
uniprot id: Q9I957
names: Subcellular Location Annotation
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

8355:zfp36l2.1.S
gene id: 8355:zfp36l2.1.S
uniprot id: Q9W674
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

8355:hdhd2.L
gene id: 8355:hdhd2.L
uniprot id: A0A1L8I2W1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

8355:LOC108716899
gene id: 8355:LOC108716899
uniprot id: A0A8J1KRY0
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

8355:ipo5.S
gene id: 8355:ipo5.S
uniprot id: Q2NL56
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:rhagl.L
gene id: 8355:rhagl.L
uniprot id: A0A1L8ET51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

8355:pitx1.L
gene id: 8355:pitx1.L
uniprot id: B7ZPG5
uniprot id: Q9W751
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Expressed in the anterior neural ridge and in the cement gland Anlage during late gastrulation/early neurulation.
messages: Nucleus
messages: Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.

8355:LOC108710514
gene id: 8355:LOC108710514
uniprot id: A0A1L8H4G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC121394136
gene id: 8355:LOC121394136
uniprot id: A0A8J1KS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8355:LOC108695725
gene id: 8355:LOC108695725
uniprot id: A0A1L8FIJ9
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108714361
gene id: 8355:LOC108714361
uniprot id: A0A8J0V2C8
names: Subcellular Location Annotation
messages: Nucleus

8355:ntmt1.L
gene id: 8355:ntmt1.L
uniprot id: A0A8J1LFC7
uniprot id: A0A8J1LHF5
uniprot id: Q4KL94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. NTM1 family.
messages: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on target proteins.
messages: Nucleus

8355:LOC121402274
gene id: 8355:LOC121402274
uniprot id: A0A8J1MSM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:cisd2.L
gene id: 8355:cisd2.L
uniprot id: Q6PCF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CISD protein family. CISD2 subfamily.
messages: Binds 1 [2Fe-2S] cluster.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Mitochondrion outer membrane
messages: Regulator of autophagy that contributes to antagonize becn1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of bcl2 with becn1 and is required for bcl2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy (By similarity).

8355:myo1e.2.L
gene id: 8355:myo1e.2.L
uniprot id: Q2TAV1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:LOC121396017
gene id: 8355:LOC121396017
uniprot id: A0A8J1LAJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

8355:kdm5c.S
gene id: 8355:kdm5c.S
uniprot id: A0A1L8F1H7
uniprot id: A0A8J0TGB3
uniprot id: A0A8J0TMU4
uniprot id: A0A8J0TPY5
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

8355:LOC108701197
gene id: 8355:LOC108701197
uniprot id: A0A8J1LVG6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

8355:npr3.S
gene id: 8355:npr3.S
uniprot id: A0A1L8HRT2
uniprot id: A0A8J0UDP3
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108708480
gene id: 8355:LOC108708480
uniprot id: A0A8J0UIU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

8355:ppp6r1.L
gene id: 8355:ppp6r1.L
uniprot id: A0A8J0T812
uniprot id: A0A8J0T814
uniprot id: A0A8J1L5T2
uniprot id: A0A8J1L6T9
uniprot id: Q6PCI0
names: Similarity
messages: Belongs to the SAPS family.

8355:hunk.L
gene id: 8355:hunk.L
uniprot id: Q5XHI9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

8355:rnf149.L
gene id: 8355:rnf149.L
uniprot id: Q6NRX0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
messages: Membrane
messages: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.

8355:LOC108710528
gene id: 8355:LOC108710528
uniprot id: A0A1L8H4I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:xk.L
gene id: 8355:xk.L
uniprot id: A0A1L8HGM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

8355:LOC443722
gene id: 8355:LOC443722
uniprot id: A0A1L8FBR5
names: Similarity
messages: Belongs to the peptidase C1 family.

8355:ap3s1.S
gene id: 8355:ap3s1.S
uniprot id: A0A8J1LJQ8
uniprot id: Q8AVV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

8355:LOC108717425
gene id: 8355:LOC108717425
uniprot id: A0A8J1KUY4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:sys1.S
gene id: 8355:sys1.S
uniprot id: Q641B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

8355:LOC108700330
gene id: 8355:LOC108700330
uniprot id: A0A1L8F4F1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8355:LOC121402809
gene id: 8355:LOC121402809
uniprot id: A0A8J1MVF6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

8355:bend5.S
gene id: 8355:bend5.S
uniprot id: Q3B8D4
names: Domain
names: Function
messages: May act as a transcriptional repressor.
messages: The BEN domain mediates DNA-binding.

8355:slc6a3.S
gene id: 8355:slc6a3.S
uniprot id: A0A1L8FS41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
messages: Cell membrane
messages: Membrane
messages: axon
messages: neuron projection

8355:cnih4.L
gene id: 8355:cnih4.L
uniprot id: A9JS89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

8355:LOC121393868
gene id: 8355:LOC121393868
uniprot id: A0A8J1KQF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

8355:LOC108699292
gene id: 8355:LOC108699292
uniprot id: A0A8J0TLA4
uniprot id: A0A8J1LIF8
uniprot id: A0A8J1LIL2
uniprot id: A0A8J1LJT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

8355:slc2a9.S
gene id: 8355:slc2a9.S
uniprot id: A0A1L8FEL2
uniprot id: Q6INT8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:nradd.L
gene id: 8355:nradd.L
uniprot id: Q9PVD4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:agpat1.S
gene id: 8355:agpat1.S
uniprot id: A0A1L8F3L6
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

8355:LOC108700977
gene id: 8355:LOC108700977
uniprot id: A0A8J0TUG6
uniprot id: A0A8J1LTM6
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

8355:adam21.L
gene id: 8355:adam21.L
uniprot id: O42593
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:LOC108695658
gene id: 8355:LOC108695658
uniprot id: A0A1L8I030
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:LOC108696969
gene id: 8355:LOC108696969
uniprot id: A0A8J1L8V8
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:pax7.L
gene id: 8355:pax7.L
uniprot id: A0A8J0SZL8
uniprot id: A0A8J0T6F9
uniprot id: B7ZRC7
uniprot id: Q645N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8355:LOC108703094
gene id: 8355:LOC108703094
uniprot id: A0A1L8EQ13
names: Similarity
messages: Belongs to the globin family.

8355:LOC121395493
gene id: 8355:LOC121395493
uniprot id: A0A8J1L620
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108699336
gene id: 8355:LOC108699336
uniprot id: Q5XGY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both dmc1- and rad51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (By similarity).

8355:LOC108709734
gene id: 8355:LOC108709734
uniprot id: A0A8J0UL93
names: Subcellular Location Annotation
messages: Nucleus

8355:tbx5.S
gene id: 8355:tbx5.S
uniprot id: A0A1L8HPY2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8355:LOC121395114
gene id: 8355:LOC121395114
uniprot id: A0A8J1L4X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

8355:erc1.L
gene id: 8355:erc1.L
uniprot id: A0A8J0TX48
uniprot id: A0A8J0TX52
uniprot id: A0A8J0U4B3
uniprot id: A0A8J0U4Y7
uniprot id: A0A8J0U4Z2
uniprot id: A0A8J0U5L5
uniprot id: A0A8J0U7R6
uniprot id: A0A8J1MJE1
uniprot id: A0A8J1MJF5
uniprot id: A0A8J1MK61
uniprot id: A0A8J1MKF1
uniprot id: A0A8J1MLG4
names: Subcellular Location Annotation
messages: Cytoplasm

8355:ccni.L
gene id: 8355:ccni.L
uniprot id: Q6P7H3
names: Similarity
messages: Belongs to the cyclin family.

8355:LOC121401446
gene id: 8355:LOC121401446
uniprot id: A0A8J1MM10
names: Subcellular Location Annotation
messages: Membrane

8355:med8.L
gene id: 8355:med8.L
uniprot id: Q5HZZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: Component of the Mediator complex. May be part of a multisubunit E3 ubiquitin-protein ligase complex (By similarity).
messages: Nucleus

8355:pabir2.L
gene id: 8355:pabir2.L
uniprot id: A0A1L8F843
uniprot id: A0A8J0TH56
uniprot id: A0A8J0TKI4
uniprot id: A0A8J1LGQ4
uniprot id: A0A8J1LHA4
uniprot id: A0A8J1LHA9
uniprot id: A0A8J1LI42
uniprot id: A0A8J1LJ72
names: Similarity
messages: Belongs to the FAM122 family.

8355:zc2hc1c.S
gene id: 8355:zc2hc1c.S
uniprot id: A0A8J0TFS4
uniprot id: A0A8J1LNA1
names: Similarity
messages: Belongs to the ZC2HC1 family.

8355:clu.L
gene id: 8355:clu.L
uniprot id: Q7ZWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol

8355:LOC108712739
gene id: 8355:LOC108712739
uniprot id: A0A8J0UPC8
uniprot id: A0A8J1MQI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

8355:stmn1.L
gene id: 8355:stmn1.L
uniprot id: Q09006
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accumulates during oogenesis and remains stable as a maternal product throughout early development.
messages: Belongs to the stathmin family.
messages: Binds to two alpha/beta-tubulin heterodimers.
messages: Different phosphorylated forms, from unphosphorylated to highly phosphorylated, are found in the mature egg. Progressive dephosphorylation from the mid-blastula to the tailbud stage.
messages: Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity).
messages: Ubiquitous. Mostly abundant in brain and oocytes.
messages: cytoskeleton

8355:LOC108699859
gene id: 8355:LOC108699859
uniprot id: A0A1L8F0S0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:zfyve28.L
gene id: 8355:zfyve28.L
uniprot id: Q6DCE1
names: Similarity
messages: Belongs to the lst-2 family.

8355:mmp21.L
gene id: 8355:mmp21.L
uniprot id: O93470
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 1 zinc ion per subunit.
messages: Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway.
messages: Secreted
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: The precursor is cleaved by a furin endopeptidase.
messages: Transiently expressed during embryo development. Undetected in the blastula stage embryo, induced in gastrula embryo, expressed in neurula embryo, and then down-regulated in pretailbud embryo.

8355:vcp.S
gene id: 8355:vcp.S
uniprot id: P23787
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATPase activity is inhibited or reduced by lowering pH from 9.0 to 7.0, and by addition of Ca(2+), EDTA, KNO(3) or by treatment with N-ethylmaleimide (NEM).
messages: Belongs to the AAA ATPase family.
messages: Endoplasmic reticulum
messages: Expressed in at least oocytes, liver and kidney (at protein level).
messages: Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry. Interacts with the FACT/DUF complex, which contains subunits ssrp1/duf87 and supt16h/duf140.
messages: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Plays a role in the regulation of stress granules (SGs) clearance process upon arsenite-induced response (By similarity). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (By similarity). Together with sprtn metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (By similarity). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (PubMed:30979826, PubMed:30849395, PubMed:30842657). Enhances cell cycle progression and inhibits apoptosis at low temperatures (By similarity). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (By similarity). Acts as a negative regulator of type I interferon production by promoting ubiquitination of rigi (By similarity). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (By similarity). May more particularly play a role in caveolins sorting in cells (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly…
messages: Nucleus
messages: Phosphorylated.
messages: Stress granule
messages: cytosol

8355:LOC121401307
gene id: 8355:LOC121401307
uniprot id: A0A8J1MJQ4
names: Subcellular Location Annotation
messages: Membrane

8355:cxxc1.S
gene id: 8355:cxxc1.S
uniprot id: Q6INJ5
names: Subcellular Location Annotation
messages: Nucleus

8355:c17orf58.L
gene id: 8355:c17orf58.L
uniprot id: A2BDC9
names: Similarity
messages: Belongs to the UPF0450 family.

8355:LOC108701189
gene id: 8355:LOC108701189
uniprot id: A0A8J0TVD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

8355:LOC121402013
gene id: 8355:LOC121402013
uniprot id: A0A1L8HT68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:wnt9a.L
gene id: 8355:wnt9a.L
uniprot id: A0A8J0VJI7
uniprot id: A0A8J0VNB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8355:svep1l.S
gene id: 8355:svep1l.S
uniprot id: A0A1L8F4Q8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:clcc1.S
gene id: 8355:clcc1.S
uniprot id: A0A8J0V4A0
uniprot id: Q91892
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Nucleus membrane
messages: Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (By similarity).

8355:LOC108710727
gene id: 8355:LOC108710727
uniprot id: A0A1L8GW59
uniprot id: A0A8J0UH72
uniprot id: A0A8J1MJ54
uniprot id: A0A8J1MJ69
uniprot id: A0A8J1MJV6
uniprot id: A0A8J1MK62
uniprot id: A0A8J1ML70
names: Similarity
messages: Belongs to the BicD family.

8355:LOC734210
gene id: 8355:LOC734210
uniprot id: A0A8J1M290
uniprot id: A0A8J1M297
uniprot id: A0A8J1M3D6
uniprot id: A0A8J1M445
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

8355:cwc15.S
gene id: 8355:cwc15.S
uniprot id: Q6NUB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC15 family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing as component of the spliceosome.
messages: Nucleus

8355:slc45a2.L
gene id: 8355:slc45a2.L
uniprot id: Q566F3
names: Subcellular Location Annotation
messages: Membrane

8355:samd8.S
gene id: 8355:samd8.S
uniprot id: A0A8J0U4T0
uniprot id: A0A8J1LC51
uniprot id: A0A8J1LDN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

8355:denr.S
gene id: 8355:denr.S
uniprot id: A0A8J0U9Y7
names: Similarity
messages: Belongs to the DENR family.

8355:kcna7.S
gene id: 8355:kcna7.S
uniprot id: Q98TW2
names: Subcellular Location Annotation
messages: Membrane

8355:LOC121400606
gene id: 8355:LOC121400606
uniprot id: A0A8J1ME19
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:nxpe2.L
gene id: 8355:nxpe2.L
uniprot id: A0A1L8FL80
uniprot id: A0A8J1L4N5
uniprot id: Q5U498
names: Similarity
messages: Belongs to the NXPE family.

8355:LOC108700494
gene id: 8355:LOC108700494
uniprot id: A0A8J0TT28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:fscn2.S
gene id: 8355:fscn2.S
uniprot id: A0A1L8EM76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

8355:LOC108702369
gene id: 8355:LOC108702369
uniprot id: A0A8J0TYF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:fzd1.L
gene id: 8355:fzd1.L
uniprot id: Q9I9M5
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in unfertilized eggs. Not detected in late gastrula or early neurula stages. Expressed in mid-neurula stages and maintained through tadpole stages.
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: In the embryo, expressed in the heart, pronephros and otic vesicles.
messages: Interacts with wnt8.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10969734). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10969734). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
messages: The FZ domain is involved in binding with Wnt ligands.

8355:acod1.S
gene id: 8355:acod1.S
uniprot id: A0A1L8H9G8
names: Similarity
messages: Belongs to the PrpD family.

8355:hdac1.S
gene id: 8355:hdac1.S
uniprot id: Q7ZYT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Cytoplasm
messages: Nucleus

8355:LOC108702297
gene id: 8355:LOC108702297
uniprot id: A0A8J0TZK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

8355:LOC108711298
gene id: 8355:LOC108711298
uniprot id: A0A1L8H018
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8355:LOC108712315
gene id: 8355:LOC108712315
uniprot id: A0A8J1MRX0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

8355:gad1.1.L
gene id: 8355:gad1.1.L
uniprot id: A0A8J0TQD9
uniprot id: A0A8J1LSK2
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

8355:zpr1.L
gene id: 8355:zpr1.L
uniprot id: B1H1S5
names: Similarity
messages: Belongs to the ZPR1 family.

8355:metap2.S
gene id: 8355:metap2.S
uniprot id: Q0P3Q4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

8355:sla2.S
gene id: 8355:sla2.S
uniprot id: A0A1L8EMX7
names: Subcellular Location Annotation
messages: Cytoplasm

8355:sema3e.S
gene id: 8355:sema3e.S
uniprot id: A0A1L8GTW0
uniprot id: A0A8J1MST0
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:itih5.S
gene id: 8355:itih5.S
uniprot id: A0A1L8GTQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

8355:LOC108696407
gene id: 8355:LOC108696407
uniprot id: A0A1L8FL92
names: Similarity
messages: Belongs to the NXPE family.

8355:ate1.S
gene id: 8355:ate1.S
uniprot id: Q6INP2
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

8355:hsp90ab1.S
gene id: 8355:hsp90ab1.S
uniprot id: A0A8J0VJ01
uniprot id: Q6AZV1
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: In contrast to other HSP90 heat shock proteins, this one is not induced by heat shock or mitogenic stimuli but is strictly constitutive.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle.
messages: Monomer. Homodimer (By similarity).
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.

8355:LOC108709121
gene id: 8355:LOC108709121
uniprot id: A0A1L8H8Z4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

8355:LOC121398856
gene id: 8355:LOC121398856
uniprot id: A0A8J1LXL1
uniprot id: A0A8J1LXL3
uniprot id: A0A8J1LXX4
uniprot id: A0A8J1LYX1
uniprot id: A0A8J1LZU6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

8355:becn1.L
gene id: 8355:becn1.L
uniprot id: A0A8J1LSS5
uniprot id: Q6GP52
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beclin family.
messages: Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: May be proteolytically processed by caspases; the C-terminal fragment(s) may induce apoptosis.
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (By similarity). Involved in endocytosis including endosome formation in neuronal cells (By similarity).
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

8355:usp7.L
gene id: 8355:usp7.L
uniprot id: A0A1L8EXJ7
uniprot id: A0A8J0TNB1
uniprot id: A0A8J0TVD3
uniprot id: A0A8J0TWX8
names: Similarity
messages: Belongs to the peptidase C19 family.

8355:prr5l.L
gene id: 8355:prr5l.L
uniprot id: A0A1L8GIN7
uniprot id: A0A8J0UUE2
uniprot id: A0A8J0V011
names: Similarity
messages: Belongs to the PROTOR family.

8355:wdr45b.S
gene id: 8355:wdr45b.S
uniprot id: Q68F45
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2.
messages: Lysosome
messages: Preautophagosomal structure
messages: The L/FRRG motif is required for recruitment to PtdIns3P.

8355:MGC130623
gene id: 8355:MGC130623
uniprot id: B3DLM4
uniprot id: Q3B8M8
names: Similarity
messages: Belongs to the TENT family.

8355:trmt10c.S
gene id: 8355:trmt10c.S
uniprot id: A0A1L8H8F1
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

8355:tnfrsf21.L
gene id: 8355:tnfrsf21.L
uniprot id: A0A1L8GC21
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:vamp8.L
gene id: 8355:vamp8.L
uniprot id: A0A1L8H1L5
uniprot id: Q5XGY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

8355:slc2a11.L
gene id: 8355:slc2a11.L
uniprot id: A0A1L8I0F1
uniprot id: A0A8J1KZE6
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8355:pip4p1.L
gene id: 8355:pip4p1.L
uniprot id: Q5XKA6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Late endosome membrane
messages: Lysosome membrane

8355:tcf19.L
gene id: 8355:tcf19.L
uniprot id: A0A1L8F8I8
names: Subcellular Location Annotation
messages: Nucleus

8355:LOC108698198
gene id: 8355:LOC108698198
uniprot id: A0A8J0TJF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:LOC121401481
gene id: 8355:LOC121401481
uniprot id: A0A8J1MMB0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108705351
gene id: 8355:LOC108705351
uniprot id: A0A8J1M557
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

8355:chmp4c.S
gene id: 8355:chmp4c.S
uniprot id: A0A1L8FTF1
names: Similarity
messages: Belongs to the SNF7 family.

8355:LOC100127300
gene id: 8355:LOC100127300
uniprot id: A0A8J0TGM9
uniprot id: A9JS41
names: Similarity
messages: Belongs to the S-100 family.

8355:trit1.L
gene id: 8355:trit1.L
uniprot id: A0A1L8HFZ0
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

8355:cdk20.S
gene id: 8355:cdk20.S
uniprot id: Q3B8E6
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:gcnt1.L
gene id: 8355:gcnt1.L
uniprot id: Q801N9
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

8355:b4galnt1.S
gene id: 8355:b4galnt1.S
uniprot id: A0A1L8H9W8
uniprot id: A0A8J1MF74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:erap1.S
gene id: 8355:erap1.S
uniprot id: A0A8J1M3X1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

8355:LOC108700895
gene id: 8355:LOC108700895
uniprot id: A0A1L8ESP7
names: Subcellular Location Annotation
messages: Membrane

8355:oprl1.L
gene id: 8355:oprl1.L
uniprot id: A0A8J0QHS1
uniprot id: Q2A078
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

8355:LOC108702934
gene id: 8355:LOC108702934
uniprot id: A0A1L8ENS1
names: Subcellular Location Annotation
messages: Nucleus

8355:adcyap1r1.L
gene id: 8355:adcyap1r1.L
uniprot id: A0A8J1KWL1
uniprot id: A0A8J1KWL7
uniprot id: A0A8J1KWM2
uniprot id: A0A8J1KZJ2
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108717407
gene id: 8355:LOC108717407
uniprot id: A0A8J1KUD3
uniprot id: A0A8J1KVU2
names: Similarity
messages: Belongs to the nesprin family.

8355:ano1.L
gene id: 8355:ano1.L
uniprot id: A0A8J0USE7
uniprot id: A0A8J1MT62
uniprot id: A0A8J1MT68
uniprot id: A0A8J1MTD7
uniprot id: A0A8J1MU91
uniprot id: A0A8J1MUK7
uniprot id: A0A8J1MVG9
uniprot id: B5SVV6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:LOC108711602
gene id: 8355:LOC108711602
uniprot id: A0A1L8H1Y4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:LOC108702476
gene id: 8355:LOC108702476
uniprot id: A0A1L8EKL6
names: Similarity
messages: Belongs to the intermediate filament family.

8355:pcdhgc4.L
gene id: 8355:pcdhgc4.L
uniprot id: A0A1L8GX64
uniprot id: A0A8J0UNZ2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

8355:LOC108715436
gene id: 8355:LOC108715436
uniprot id: A0A1L8GF55
names: Subcellular Location Annotation
messages: Membrane

8355:b3galt5l.L
gene id: 8355:b3galt5l.L
uniprot id: A0A1L8HCH9
uniprot id: A0A8J1M811
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

8355:capn13.L
gene id: 8355:capn13.L
uniprot id: A0A8J1KL07
uniprot id: Q7ZYF3
names: Similarity
messages: Belongs to the peptidase C2 family.

8355:LOC108696083
gene id: 8355:LOC108696083
uniprot id: A0A8J0T0G6
uniprot id: A0A8J1L9G4
uniprot id: A0A8J1LB13
names: Similarity
messages: Belongs to the ARID5B family.

8355:hdgfl2.S
gene id: 8355:hdgfl2.S
uniprot id: A0A1L8HMX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

8355:kcnb2.S
gene id: 8355:kcnb2.S
uniprot id: A0A1L8FT68
uniprot id: Q91592
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon

8355:slc44a4.L
gene id: 8355:slc44a4.L
uniprot id: Q6GN42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CTL (choline transporter-like) family.
messages: Choline transporter that seems to play a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury.
messages: Membrane

8355:irs4.L
gene id: 8355:irs4.L
uniprot id: Q5RJW5
names: Function
names: PTM
messages: Phosphorylated by INSR.
messages: Potentiates insulin signaling.

8355:XB5896658.L
gene id: 8355:XB5896658.L
uniprot id: A0A1L8F7S0
names: Similarity
messages: Belongs to the syntaxin family.

8355:prdm1.L
gene id: 8355:prdm1.L
uniprot id: A0A1L8G929
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

8355:best1.S
gene id: 8355:best1.S
uniprot id: A0A1L8GD79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

8355:slc13a1.L
gene id: 8355:slc13a1.L
uniprot id: A0A8J0UUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8355:LOC121400925
gene id: 8355:LOC121400925
uniprot id: A0A1L8HZR8
names: Subcellular Location Annotation
messages: Membrane

8355:astl2a.S
gene id: 8355:astl2a.S
uniprot id: A0A8J1KHP5
uniprot id: A0A8J1KJH3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:sim1.L
gene id: 8355:sim1.L
uniprot id: A0A1L8G9C3
names: Subcellular Location Annotation
messages: Nucleus

8355:fmo5.2.S
gene id: 8355:fmo5.2.S
uniprot id: Q6PB07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8355:cd37.S
gene id: 8355:cd37.S
uniprot id: A0A1L8FGP7
uniprot id: Q66J31
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8355:drd4.S
gene id: 8355:drd4.S
uniprot id: A0A1L8GDG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:krt78.3.L
gene id: 8355:krt78.3.L
uniprot id: A0A8J0U4M2
names: Similarity
messages: Belongs to the intermediate filament family.

8355:smpdl3b.S
gene id: 8355:smpdl3b.S
uniprot id: A0A1L8H7I0
uniprot id: A0A8J1MER7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

8355:itga4.S
gene id: 8355:itga4.S
uniprot id: Q91687
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin alpha chain family.
messages: Fibronectin and V-CAM adhesion receptor.
messages: Heterodimer of an alpha and a beta subunit.
messages: Membrane

8355:sema3a.L
gene id: 8355:sema3a.L
uniprot id: A0A8J0UQV9
uniprot id: Q8JIW9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:ventx1.1.L
gene id: 8355:ventx1.1.L
uniprot id: O42173
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: By bmp4 and its downstream effector smad1. Fgf enhances bmp4-induced expression.
messages: Expressed in the ventral marginal zone of blastulae. At early gastrulation, expression begins to spread to the animal pole (ectoderm), and at stage 11.5 is expressed in a gradient across the animal cap, with levels highest in the ventral region. At the end of gastrulation, predominantly localized to the ventral and lateral regions of the closing slit blastopore. Also expressed at a low level in ventral endoderm.
messages: Expression begins in the late blastula, peaks at stage 11 (early gastrula) and decreases thereafter.
messages: Nucleus
messages: The repressor activity is mostly localized to the C-terminal region.
messages: Transcriptional repressor. Acts in a ventral signaling pathway downstream of bmp4, which suppresses dorsal mesoderm formation and leads to both ventral mesoderm and ventral ectoderm formation. Acts in the ectoderm to simultaneously specify epidermal lineages and restrict neuralization. Represses transcription of dorsal-specific genes. Binds to DNA, with preference for the target sequences 5'-TAATGC-3' and 5'-TAATTG-3'. Acts in a pathway downstream of bmp4 and fgf to negatively regulate erythroid specification.

8355:plk1.L
gene id: 8355:plk1.L
uniprot id: A0A1L8EYC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

8355:atxn1l.S
gene id: 8355:atxn1l.S
uniprot id: B1WBC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

8355:hnrnpa1.S
gene id: 8355:hnrnpa1.S
uniprot id: A0A8J0UGK1
uniprot id: Q7ZX33
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8355:LOC108702460
gene id: 8355:LOC108702460
uniprot id: A0A8J0TZU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the orexin family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum
messages: Synapse
messages: Vesicle

8355:polr3g.L
gene id: 8355:polr3g.L
uniprot id: A0A1L8I1Q7
uniprot id: Q5BIY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

8355:cpd.L
gene id: 8355:cpd.L
uniprot id: A0A1L8HD56
names: Similarity
messages: Belongs to the peptidase M14 family.

8355:unc5c.L
gene id: 8355:unc5c.L
uniprot id: A0A1L8HV55
uniprot id: A0A8J0UNZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

8355:fam174b.L
gene id: 8355:fam174b.L
uniprot id: A0A1L8H0Z9
uniprot id: A0A8J0URD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

8355:abraxas2.L
gene id: 8355:abraxas2.L
uniprot id: A0A1L8FJ15
names: Subcellular Location Annotation
messages: Nucleus

8355:sult1b1.L
gene id: 8355:sult1b1.L
uniprot id: A0A8J1LP58
uniprot id: A5D8P4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

8355:dhps.S
gene id: 8355:dhps.S
uniprot id: A0A8J1MP09
uniprot id: Q6NRS5
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

8355:tpi1.S
gene id: 8355:tpi1.S
uniprot id: Q7ZWN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

8355:rcan2.L
gene id: 8355:rcan2.L
uniprot id: A0A1L8GBN6
uniprot id: A0A8J1KRY6
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

8355:slc37a2.S
gene id: 8355:slc37a2.S
uniprot id: A0A8J0U542
uniprot id: A0A8J1LCH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

8355:naga.L
gene id: 8355:naga.L
uniprot id: A0A1L8EXG5
uniprot id: Q6GR44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

8355:sf3b4.S
gene id: 8355:sf3b4.S
uniprot id: A0A8J0TN76
uniprot id: Q7ZX30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

8355:LOC108717391
gene id: 8355:LOC108717391
uniprot id: A0A1L8I2G3
uniprot id: A0A8J1L4K2
uniprot id: A0A8J1L677
uniprot id: A0A8J1L784
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus

8355:LOC108697168
gene id: 8355:LOC108697168
uniprot id: A0A1L8FE15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:nckap1.L
gene id: 8355:nckap1.L
uniprot id: Q640K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEM-1/HEM-2 family.
messages: Cell membrane
messages: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). Plays a role in neural tube closure.
messages: lamellipodium membrane

8355:ugt3a2.L
gene id: 8355:ugt3a2.L
uniprot id: Q63ZR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane
messages: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).

8355:smim15.S
gene id: 8355:smim15.S
uniprot id: A9JTJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

8355:LOC108710019
gene id: 8355:LOC108710019
uniprot id: A0A1L8HAZ8
uniprot id: A0A8J0UL21
names: Subcellular Location Annotation
messages: Membrane

8355:nodal6.S
gene id: 8355:nodal6.S
uniprot id: Q2PG67
names: Similarity
messages: Belongs to the TGF-beta family.

8355:sla2.L
gene id: 8355:sla2.L
uniprot id: Q7T0U4
names: Subcellular Location Annotation
messages: Cytoplasm

8355:stmn2.L
gene id: 8355:stmn2.L
uniprot id: Q09001
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: Nervous tissue.
messages: lamellipodium

8355:vasn.S
gene id: 8355:vasn.S
uniprot id: A0A1L8EQQ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:txndc15.L
gene id: 8355:txndc15.L
uniprot id: Q0IHI1
names: Function
names: Subcellular Location Annotation
messages: Acts as a positive regulator of ciliary hedgehog signaling. Required for cilia biogenesis.
messages: cilium membrane

8355:LOC121401310
gene id: 8355:LOC121401310
uniprot id: A0A8J1MIR9
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:dlg5.L
gene id: 8355:dlg5.L
uniprot id: A0A8J0TVT4
uniprot id: A0A8J0U321
uniprot id: A0A8J0U3I4
uniprot id: A0A8J0U4B5
uniprot id: A0A8J0U6B1
names: Subcellular Location Annotation
messages: Cytoplasm

8355:fahd2a.L
gene id: 8355:fahd2a.L
uniprot id: A0A1L8H1M1
uniprot id: Q6GLT8
names: Function
names: Similarity
messages: Belongs to the FAH family.
messages: May have hydrolase activity.

8355:prr15.S
gene id: 8355:prr15.S
uniprot id: A0A1L8FRB6
names: Similarity
messages: Belongs to the PRR15 family.

8355:dmbx1.S
gene id: 8355:dmbx1.S
uniprot id: A0A1L8GFS8
uniprot id: A0A8J1KJ76
names: Subcellular Location Annotation
messages: Nucleus

8355:macir.L
gene id: 8355:macir.L
uniprot id: A0A1L8I1M2
uniprot id: A0A8J1M6A2
uniprot id: Q6DFB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: Interacts with unc119 family proteins; interaction preferentially takes place when unc119 proteins are unliganded with myristoylated proteins.
messages: May play a role in immune regulation through regulation of the macrophage function (By similarity). May also play a role in trafficking of proteins via its interaction with unc119 family cargo adapters (By similarity). May play a role in ciliary membrane localization (By similarity).
messages: cilium

8355:nsg1.L
gene id: 8355:nsg1.L
uniprot id: A0A1L8HTC1
names: Similarity
messages: Belongs to the NSG family.

8355:LOC108695629
gene id: 8355:LOC108695629
uniprot id: A0A1L8HZD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:hbg2.L
gene id: 8355:hbg2.L
uniprot id: P02133
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.

8355:LOC121393574
gene id: 8355:LOC121393574
uniprot id: A0A8J1KLZ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:XB5756214.L
gene id: 8355:XB5756214.L
uniprot id: Q6AX04
names: Similarity
messages: Belongs to the MHC class I family.

8355:slc6a8l.L
gene id: 8355:slc6a8l.L
uniprot id: A0A1L8GPW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

8355:MGC81152
gene id: 8355:MGC81152
uniprot id: A0A8J0UA23
uniprot id: A0A8J0UGR6
uniprot id: A0A8J1MBC4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC108702428
gene id: 8355:LOC108702428
uniprot id: A0A1L8EQL3
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

8355:bfsp1.L
gene id: 8355:bfsp1.L
uniprot id: Q6DKC1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

8355:kcnk6.L
gene id: 8355:kcnk6.L
uniprot id: Q801T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

8355:LOC108715405
gene id: 8355:LOC108715405
uniprot id: A0A8J0V6Q2
names: Similarity
messages: Belongs to the cyclin family.

8355:ednra.L
gene id: 8355:ednra.L
uniprot id: Q7ZXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

8355:rcor2.L
gene id: 8355:rcor2.L
uniprot id: Q6NRZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoREST family.
messages: May act as a component of a corepressor complex that represses transcription.
messages: Nucleus

8355:LOC108709564
gene id: 8355:LOC108709564
uniprot id: A0A1L8H7X8
uniprot id: A0A8J0UNE2
uniprot id: A0A8J1MDY1
uniprot id: A0A8J1MEE1
uniprot id: A0A8J1MEW4
uniprot id: A0A8J1MFS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

8355:gcnt1.S
gene id: 8355:gcnt1.S
uniprot id: A0A1L8HP84
uniprot id: Q5XH18
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

8355:tmem132e.S
gene id: 8355:tmem132e.S
uniprot id: A0A8J0UIW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

8355:smagp.L
gene id: 8355:smagp.L
uniprot id: A0A1L8HI84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

8355:pfn2.L
gene id: 8355:pfn2.L
uniprot id: Q7ZWT1
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

8355:LOC121400095
gene id: 8355:LOC121400095
uniprot id: A0A8J1MB47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:foxm1.S
gene id: 8355:foxm1.S
uniprot id: A0A8J0UUS4
uniprot id: Q5W1J6
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically. Maternal levels decrease rapidly until the blastula stage. Absent from gastrula stage embryos and then zygotic expression starts during neurulation and persists until the end of organogenesis.
messages: Localized to the animal hemisphere of early cleavage stage embryos. During neurulation, expressed in the neural folds. Later, expressed in the spinal cord and in the eye field. During tailbud stages, expression is still restricted to the neuroectoderm, predominantly to the hindbrain, the eye and the spinal cord. With ongoing development, expression is also found at lower levels in the branchial arches. At stage 35, expressed in the rhombencephalon and in the eye retina.
messages: Nucleus
messages: Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2.

8355:LOC108711134
gene id: 8355:LOC108711134
uniprot id: A0A1L8GYS9
uniprot id: A0A1L8GYT7
names: Similarity
messages: Belongs to the MDFI family.

8355:ccr7.S
gene id: 8355:ccr7.S
uniprot id: A0A8J0PW80
uniprot id: Q6GP68
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:panx3.S
gene id: 8355:panx3.S
uniprot id: A0A1L8FFR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

8355:b4galt5.L
gene id: 8355:b4galt5.L
uniprot id: Q6DDI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:gata2.S
gene id: 8355:gata2.S
uniprot id: A0A8J1KK25
uniprot id: A0A8J1KK37
names: Subcellular Location Annotation
messages: Nucleus

8355:pax5.L
gene id: 8355:pax5.L
uniprot id: A0A8J1MNT9
uniprot id: Q9YH95
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: First detected in mid-neurula embryos in the folding neural tube. With the completion of neurulation, expression becomes localized to the midbrain/hindbrain boundary (MHB) till at least stage 40. Expression is absent from regions adjacent to the MHB. In tailbuds, weakly and transiently expressed in the developing otic vesicle from stage 21 to stage 27.
messages: Nucleus
messages: Probable transcription factor.

8355:tcp11l2.S
gene id: 8355:tcp11l2.S
uniprot id: A0A1L8GUV5
uniprot id: A0A8J0UWW6
names: Similarity
messages: Belongs to the TCP11 family.

8355:nup188.S
gene id: 8355:nup188.S
uniprot id: A0A1L8F1N1
names: Subcellular Location Annotation
messages: nuclear pore complex

8355:mpi.S
gene id: 8355:mpi.S
uniprot id: A0A1L8GT78
uniprot id: A0A8J0UWU0
uniprot id: A0A8J0UX16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

8355:pknox2.S
gene id: 8355:pknox2.S
uniprot id: A0A1L8FFV0
uniprot id: A0A8J0T6G9
uniprot id: A0A8J1LCJ8
uniprot id: A0A8J1LCP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

8355:LOC121393206
gene id: 8355:LOC121393206
uniprot id: A0A8J1KLA5
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:LOC121396936
gene id: 8355:LOC121396936
uniprot id: A0A8J1LHJ5
names: Similarity
messages: Belongs to the protein kinase superfamily.

8355:LOC108712935
gene id: 8355:LOC108712935
uniprot id: A0A8J0UVN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

8355:tgm5.L
gene id: 8355:tgm5.L
uniprot id: A0A1L8ETW6
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

8355:LOC108696020
gene id: 8355:LOC108696020
uniprot id: A0A1L8FIB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Membrane

8355:XB5717875.L
gene id: 8355:XB5717875.L
uniprot id: A0A1L8H4F5
names: Similarity
messages: Belongs to the cornifelin family.

8355:rpl7.L
gene id: 8355:rpl7.L
uniprot id: Q3B8I3
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

8355:glipr2.S
gene id: 8355:glipr2.S
uniprot id: A0A1L8F0Y9
uniprot id: A0A8J1LL40
uniprot id: Q5U4W9
names: Similarity
messages: Belongs to the CRISP family.

8355:dmac2l.L
gene id: 8355:dmac2l.L
uniprot id: Q32NR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion inner membrane

8355:nkap.L
gene id: 8355:nkap.L
uniprot id: A0A1L8F7L9
names: Similarity
messages: Belongs to the NKAP family.

8355:polr2c.S
gene id: 8355:polr2c.S
uniprot id: Q6IRR3
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

8355:LOC108697158
gene id: 8355:LOC108697158
uniprot id: A0A8J0TD89
names: Subcellular Location Annotation
messages: Membrane

8355:LOC108705429
gene id: 8355:LOC108705429
uniprot id: A0A8J0TYZ8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8355:bcl7b.L
gene id: 8355:bcl7b.L
uniprot id: A0A1L8HD00
uniprot id: A0A8J0UGE7
names: Similarity
messages: Belongs to the BCL7 family.

8355:taok2.L
gene id: 8355:taok2.L
uniprot id: Q6GPK9
names: Function
names: Similarity
messages: Activates the JNK MAP kinase pathway.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Serine/threonine-protein kinase involved in different processes such as apoptotic morphological changes, MAPK8/JNK and MAPK14/p38 MAPK signaling pathway.

8355:rhot1.S
gene id: 8355:rhot1.S
uniprot id: A0A8J1M062
uniprot id: A0A8J1M084
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

8355:dpf2.L
gene id: 8355:dpf2.L
uniprot id: A0A8J0USG4
uniprot id: Q9W638
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the requiem/DPF family.
messages: Cytoplasm
messages: May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.
messages: Nucleus

8355:vegfb.L
gene id: 8355:vegfb.L
uniprot id: A0A8J0UV40
uniprot id: A0A8J0V0M5
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

8355:KEF37 p01
gene id: 8355:KEF37_p01
uniprot id: P00160
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

8355:LOC108718811
gene id: 8355:LOC108718811
uniprot id: A0A1L8FVJ4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

8355:cops7b.S
gene id: 8355:cops7b.S
uniprot id: A0A8J0VJB1
uniprot id: Q498I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

8355:dynlt2b.S
gene id: 8355:dynlt2b.S
uniprot id: A0A8J0VG06
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8355:itsn1.L
gene id: 8355:itsn1.L
uniprot id: O42287
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for cdc42, and thereby stimulates actin nucleation mediated by wasl and the arp2/3 complex (By similarity). Involved in endocytosis of activated egfr, and probably also other growth factor receptors (By similarity).
messages: Binds epn1 and epn2.
messages: Cell membrane
messages: Cytoplasm
messages: Endomembrane system
messages: Nucleus envelope
messages: Recycling endosome
messages: clathrin-coated pit
messages: lamellipodium
messages: synaptosome

8355:LOC108696637
gene id: 8355:LOC108696637
uniprot id: A0A1L8FMN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:sh3bp4.L
gene id: 8355:sh3bp4.L
uniprot id: Q6NU51
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer or homooligomer.
messages: Nucleus
messages: Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).
messages: The SH3 domain mediates localization to the clathrin-coated pits and vesicles.
messages: clathrin-coated pit
messages: clathrin-coated vesicle

8355:XB5748694.S
gene id: 8355:XB5748694.S
uniprot id: A0A1L8FH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

8355:tyw1.S
gene id: 8355:tyw1.S
uniprot id: Q2KHP8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

8355:crygdl.12.S
gene id: 8355:crygdl.12.S
uniprot id: A0A8J0U872
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Monomer.

8355:nlgn4x.L
gene id: 8355:nlgn4x.L
uniprot id: A0A1L8HDH6
uniprot id: A0A8J0UGM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

8355:pnpo.S
gene id: 8355:pnpo.S
uniprot id: Q6GLJ5
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

8355:shcbp1.L
gene id: 8355:shcbp1.L
uniprot id: A0A8J0UZC7
uniprot id: Q640F2
names: Function
names: Subcellular Location Annotation
messages: May play a role in signaling pathways governing cellular proliferation.
messages: Midbody
messages: spindle

8355:tapt1.S
gene id: 8355:tapt1.S
uniprot id: Q5EAY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane
messages: Plays a role in primary cilia formation. Involved in cartilage and bone development. May play a role in the differentiation of cranial neural crest cells. May act as a downstream effector of hoxc8 during development.
messages: centrosome
messages: cilium basal body

8355:LOC108717589
gene id: 8355:LOC108717589
uniprot id: A0A8J0VE99
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

8355:LOC121393045
gene id: 8355:LOC121393045
uniprot id: A0A8J1MYL8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

8355:gja1.L
gene id: 8355:gja1.L
uniprot id: P16863
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A connexon is composed of a hexamer of connexins. Interacts with TMEM65.
messages: Appears during organogenesis.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Expressed in most tissues. Highest levels found in eye and brain.
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles.
messages: gap junction

8355:LOC108717944
gene id: 8355:LOC108717944
uniprot id: A0A8J0VF87
uniprot id: A0A8J1L5S1
uniprot id: A0A8J1L5T7
uniprot id: A0A8J1L8G6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

8355:LOC121395491
gene id: 8355:LOC121395491
uniprot id: A0A8J1L8Q6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:rpl31.S
gene id: 8355:rpl31.S
uniprot id: Q6NUH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

8355:snx7.S
gene id: 8355:snx7.S
uniprot id: A0A8J1MZB1
uniprot id: Q6NRY6
names: Similarity
messages: Belongs to the sorting nexin family.

8355:LOC108715122
gene id: 8355:LOC108715122
uniprot id: A0A1L8GCZ4
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

8355:myc.L
gene id: 8355:myc.L
uniprot id: P15171
uniprot id: Q6NRN4
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: C-MYC I is active in oocytes, while C-MYC II is active in both oocytes and post-gastrula embryos.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity).
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.

8355:LOC108697308
gene id: 8355:LOC108697308
uniprot id: A0A8J0TBF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:mapkbp1.L
gene id: 8355:mapkbp1.L
uniprot id: Q6DFF9
names: Function
messages: Involved in JNK signaling pathway.

8355:degs3.S
gene id: 8355:degs3.S
uniprot id: A0A8J0TH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

8355:LOC121400464
gene id: 8355:LOC121400464
uniprot id: A0A8J1MCT1
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

8355:LOC121396651
gene id: 8355:LOC121396651
uniprot id: A0A8J1LE91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

8355:pth2r.L
gene id: 8355:pth2r.L
uniprot id: A0A8J1LSN7
names: Subcellular Location Annotation
messages: Membrane

8355:anapc2.L
gene id: 8355:anapc2.L
uniprot id: A0A1L8F5K5
names: Similarity
messages: Belongs to the cullin family.

8355:prkab1.S
gene id: 8355:prkab1.S
uniprot id: A0A8J1LNS6
uniprot id: Q6GPZ3
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

8355:LOC108695577
gene id: 8355:LOC108695577
uniprot id: A0A1L8FQ56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

8355:lss.S
gene id: 8355:lss.S
uniprot id: A0A1L8EPF3
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

8355:cyb5r4.S
gene id: 8355:cyb5r4.S
uniprot id: A0A1L8G3B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

8355:mmut.S
gene id: 8355:mmut.S
uniprot id: A0A1L8G5D5
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

8355:MGC80748
gene id: 8355:MGC80748
uniprot id: A0A8J0TWT5
uniprot id: Q6GP13
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

8355:sgcz.L
gene id: 8355:sgcz.L
uniprot id: A0A8J1MUD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

8355:trarg1.S
gene id: 8355:trarg1.S
uniprot id: A0A8J0UJ76
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8355:LOC121401602
gene id: 8355:LOC121401602
uniprot id: A0A8J1MNN0
names: Similarity
messages: Belongs to the SNF7 family.

8355:igf1r.L
gene id: 8355:igf1r.L
uniprot id: A0A1L8H104
uniprot id: A0A8J1MM13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

8355:slc13a4l.L
gene id: 8355:slc13a4l.L
uniprot id: A0A1L8GJ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

8355:cel.1.S
gene id: 8355:cel.1.S
uniprot id: A2BD54
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

8355:cpsf3.L
gene id: 8355:cpsf3.L
uniprot id: Q5XGZ1
names: Subcellular Location Annotation
messages: Nucleus

8355:rpl24.S
gene id: 8355:rpl24.S
uniprot id: A0A1L8H8B8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

8355:axin1.S
gene id: 8355:axin1.S
uniprot id: Q5FWN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus

8355:aff1.L
gene id: 8355:aff1.L
uniprot id: A0A1L8HVR5
uniprot id: A0A8J0URD4
uniprot id: A0A8J1MZ67
names: Similarity
messages: Belongs to the AF4 family.

8355:plin2.S
gene id: 8355:plin2.S
uniprot id: A0A8J0TRN6
uniprot id: A0A8J1LRV4
uniprot id: Q641I6
names: Similarity
messages: Belongs to the perilipin family.

8355:LOC108710433
gene id: 8355:LOC108710433
uniprot id: A0A8J1MKP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8355:LOC108713125
gene id: 8355:LOC108713125
uniprot id: A0A1L8GUC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

8355:irak1bp1.S
gene id: 8355:irak1bp1.S
uniprot id: Q08AV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: May be part of a signaling pathway that leads to NF-kappa-B activation.
messages: Nucleus

8355:tmem205.L
gene id: 8355:tmem205.L
uniprot id: A0A1L8H2X7
uniprot id: A0A1L8H2X8
uniprot id: Q6GPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

8355:LOC108711538
gene id: 8355:LOC108711538
uniprot id: A0A8J1L5T6
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

8355:lancl2.L
gene id: 8355:lancl2.L
uniprot id: A0A1L8FWP6
names: Similarity
messages: Belongs to the LanC-like protein family.

8355:LOC121393572
gene id: 8355:LOC121393572
uniprot id: A0A8J1KNM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8355:LOC108705709
gene id: 8355:LOC108705709
uniprot id: A0A8J1M3V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

8355:MGC115708
gene id: 8355:MGC115708
uniprot id: A0A1L8HDB0
uniprot id: A0A8J0UCJ1
uniprot id: Q4V7H5
names: Similarity
messages: Belongs to the CD99 family.

8355:tmem56.2.L
gene id: 8355:tmem56.2.L
uniprot id: A0A310U3T9
uniprot id: Q6GLX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLCD4 family.
messages: Membrane

8355:LOC108700989
gene id: 8355:LOC108700989
uniprot id: A0A1L8ETG8
uniprot id: A0A1L8ETH9
uniprot id: A0A8J0TSS1
uniprot id: A0A8J0TUI1
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

8355:ncoa2.L
gene id: 8355:ncoa2.L
uniprot id: A0A1L8FZ83
uniprot id: B7ZSK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

8355:zadh2.L
gene id: 8355:zadh2.L
uniprot id: A0A1L8FYA4
uniprot id: Q66IS5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

8355:cenpl.S
gene id: 8355:cenpl.S
uniprot id: Q0IH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

8355:mrpl9.S
gene id: 8355:mrpl9.S
uniprot id: A0A8J1LKZ1
uniprot id: Q5U4L3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

8355:npnt.L
gene id: 8355:npnt.L
uniprot id: A0A1L8HUX9
uniprot id: A0A8J0UPP2
uniprot id: A0A8J0USQ0
uniprot id: A0A8J1MX77
uniprot id: A0A8J1MXF8
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8355:hjv.L
gene id: 8355:hjv.L
uniprot id: A0A1L8FBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

8355:mrpl11.S
gene id: 8355:mrpl11.S
uniprot id: A0A1L8GD13
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

8355:galk1.L
gene id: 8355:galk1.L
uniprot id: A0A1L8EUH6
uniprot id: Q6GNH2
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

8355:xxylt1.S
gene id: 8355:xxylt1.S
uniprot id: A0A8J0PYJ7
uniprot id: Q6DFE5
names: Subcellular Location Annotation
messages: Membrane

8355:tubg1.S
gene id: 8355:tubg1.S
uniprot id: Q5PQ98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.
messages: centrosome

8355:ppp1cb.S
gene id: 8355:ppp1cb.S
uniprot id: Q6GQL2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Nucleus
messages: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity (By similarity).

8355:trps1.S
gene id: 8355:trps1.S
uniprot id: Q90ZS6
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds specifically to GATA sequences.
messages: Nucleus
messages: Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1191 is the major site. Appears to be sumoylated on multiple sites (By similarity).
messages: Transcriptional repressor. Represses expression of GATA-regulated genes at selected sites and stages in vertebrate development.

8355:LOC108710321
gene id: 8355:LOC108710321
uniprot id: A0A8J0UP87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8355:eps8.L
gene id: 8355:eps8.L
uniprot id: Q6NU33
names: Similarity
messages: Belongs to the EPS8 family.

8355:gmds.S
gene id: 8355:gmds.S
uniprot id: Q6GPT8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

8355:chst3.S
gene id: 8355:chst3.S
uniprot id: A0A1L8FF85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

8355:lrrc8a.S
gene id: 8355:lrrc8a.S
uniprot id: A0A8J0TG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

8355:rhot2.L
gene id: 8355:rhot2.L
uniprot id: A0A1L8EYQ4
uniprot id: A0A8J0TWL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

8355:sec23b.L
gene id: 8355:sec23b.L
uniprot id: A0A8J1KLD4
uniprot id: Q6DJE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

8355:LOC121393112
gene id: 8355:LOC121393112
uniprot id: A0A8J1MX25
uniprot id: A0A8J1MXC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

8355:kif5c.L
gene id: 8355:kif5c.L
uniprot id: A0A1L8EVW1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8355:clns1a.S
gene id: 8355:clns1a.S
uniprot id: A0A1L8HB32
uniprot id: P54106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Component of the methylosome, a 20S complex containing at least clns1a/picln, prmt5/skb1 and wdr77/mep50; may mediate snrpd1 and snrpd3 methylation. Forms a 6S pICln-Sm complex composed of clns1a/picln, snrpd1, snrpd2, snrpe, snrpf and snrpg; ring-like structure where clns1a/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.
messages: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
messages: Nucleus
messages: cytoskeleton
messages: cytosol

8355:b4galt3l1.L
gene id: 8355:b4galt3l1.L
uniprot id: A0A1L8HC46
uniprot id: Q5PPY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

8355:desi2l.L
gene id: 8355:desi2l.L
uniprot id: A0A1L8FAL6
names: Similarity
messages: Belongs to the DeSI family.

8355:srf.S
gene id: 8355:srf.S
uniprot id: A0A1L8G0Z2
names: Subcellular Location Annotation
messages: Nucleus

8355:hip1.S
gene id: 8355:hip1.S
uniprot id: A0A1L8H618
names: Similarity
messages: Belongs to the SLA2 family.

8355:LOC108711814
gene id: 8355:LOC108711814
uniprot id: A0A8J0ULT7
uniprot id: A0A8J0USP0
uniprot id: A0A8J0UTS5
uniprot id: A0A8J0UX65
names: Subcellular Location Annotation
messages: Membrane