8022:LOC100136295
gene id: 8022:LOC100136295
uniprot id: P79823
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8022:nachra9
gene id: 8022:nachra9
uniprot id: Q8JFN7
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Expressed in the liver, olfactory mucosa, pituitary gland, hair cells of the saccule and spleen.
messages: Postsynaptic cell membrane

8022:pax7a
gene id: 8022:pax7a
uniprot id: H9NNB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8022:LOC100135792
gene id: 8022:LOC100135792
uniprot id: Q9YGF4
names: Similarity
messages: Belongs to the globin family.

8022:sumo-1
gene id: 8022:sumo-1
uniprot id: Q9PT08
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with sae2, ube2i, ranbp2, pias1 and pias2 (By similarity). Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

8022:vipr1b
gene id: 8022:vipr1b
uniprot id: Q64FL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

8022:reep5
gene id: 8022:reep5
uniprot id: C1BHZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

8022:tlr1
gene id: 8022:tlr1
uniprot id: C9EH89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8022:aptx
gene id: 8022:aptx
uniprot id: Q6EF50
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

8022:LOC100136595
gene id: 8022:LOC100136595
uniprot id: Q76K78
names: Function
names: Similarity
messages: Belongs to the calcitonin family.
messages: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

8022:LOC100136120
gene id: 8022:LOC100136120
uniprot id: Q5NDK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol

8022:adcyap1r1b
gene id: 8022:adcyap1r1b
uniprot id: Q64FL5
names: Subcellular Location Annotation
messages: Membrane

8022:manbal
gene id: 8022:manbal
uniprot id: C1BEJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

8022:ap2m1
gene id: 8022:ap2m1
uniprot id: C1BFZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: coated pit

8022:rl32
gene id: 8022:rl32
uniprot id: C1BFT6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

8022:myod
gene id: 8022:myod
uniprot id: Q91205
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

8022:LOC100135790
gene id: 8022:LOC100135790
uniprot id: Q9YGF7
names: Similarity
messages: Belongs to the globin family.

8022:LOC100135977
gene id: 8022:LOC100135977
uniprot id: Q8QGB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8022:mrp1
gene id: 8022:mrp1
uniprot id: D1KF95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

8022:LOC100135982
gene id: 8022:LOC100135982
uniprot id: Q7ZT61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

8022:KEF44 p02
gene id: 8022:KEF44_p02
uniprot id: P48177
uniprot id: Q7HET1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion membrane

8022:slc39a1
gene id: 8022:slc39a1
uniprot id: Q5QJB0
names: Subcellular Location Annotation
messages: Membrane

8022:LOC100136274
gene id: 8022:LOC100136274
uniprot id: Q5EPK6
names: Subcellular Location Annotation
messages: Membrane

8022:5ntc
gene id: 8022:5ntc
uniprot id: C1BEQ6
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

bpi-2
gene id: 8022:lbp/bpi-2
uniprot id: Q8JFX3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8022:hsp90bb
gene id: 8022:hsp90bb
uniprot id: Q5DW65
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8022:c1h15orf40
gene id: 8022:c1h15orf40
uniprot id: C1BHT8
names: Similarity
messages: Belongs to the UPF0235 family.

8022:kcnn2
gene id: 8022:kcnn2
uniprot id: Q90ZP5
names: Subcellular Location Annotation
messages: Membrane

8022:dnsl3
gene id: 8022:dnsl3
uniprot id: C1BHD9
names: Similarity
messages: Belongs to the DNase I family.

8022:c8a
gene id: 8022:c8a
uniprot id: Q5W1L1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:rorca
gene id: 8022:rorca
uniprot id: E4W7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8022:zfp313
gene id: 8022:zfp313
uniprot id: Q6J0M9
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

8022:hif1a
gene id: 8022:hif1a
uniprot id: Q98SW2
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID) (By similarity).
messages: Cytoplasm
messages: Efficient DNA binding requires heterodimerization of an alpha and a beta/ARNT subunit.
messages: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
messages: In normoxia, is hydroxylated on Asn-743, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation.
messages: In normoxia, is hydroxylated on Pro-426 and Pro-559. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (By similarity).
messages: Induced by reactive oxygen species (ROS).
messages: Nucleus
messages: Nucleus speckle
messages: The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.

8022:LOC100136780
gene id: 8022:LOC100136780
uniprot id: P45433
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Phosphorylated in its cytoplasmic tail.
messages: Seems to bind calcium.
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

8022:LOC100301866
gene id: 8022:LOC100301866
uniprot id: C1BGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

8022:tnfsf13
gene id: 8022:tnfsf13
uniprot id: A5HBL5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:il17c1
gene id: 8022:il17c1
uniprot id: D4HTR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8022:tyr
gene id: 8022:tyr
uniprot id: Q75W62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8022:txn4a
gene id: 8022:txn4a
uniprot id: C1BFB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

8022:mrb
gene id: 8022:mrb
uniprot id: Q5WP01
names: Subcellular Location Annotation
messages: Nucleus

8022:LOC100305179
gene id: 8022:LOC100305179
uniprot id: C1BGV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

8022:c1r
gene id: 8022:c1r
uniprot id: Q70W31
names: Caution
names: Function
names: Subunit
messages: C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.
messages: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:vim
gene id: 8022:vim
uniprot id: P48674
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Homomer assembled from elementary dimers.
messages: Nucleus matrix
messages: One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized.
messages: The central alpha-helical coiled-coil IF rod domain mediates elementary homodimerization.
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
messages: cytoskeleton

8022:ifn3
gene id: 8022:ifn3
uniprot id: A8E0J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

8022:pfd4
gene id: 8022:pfd4
uniprot id: C1BFJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

8022:KEF44 p01
gene id: 8022:KEF44_p01
uniprot id: E2JDK9
uniprot id: P48173
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

8022:ar-alpha
gene id: 8022:ar-alpha
uniprot id: O93244
names: Subcellular Location Annotation
messages: Nucleus

8022:igfbp6
gene id: 8022:igfbp6
uniprot id: Q3HWG4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:gstk1
gene id: 8022:gstk1
uniprot id: C1BHF3
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

8022:ck073
gene id: 8022:ck073
uniprot id: C1BH37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

8022:esr1
gene id: 8022:esr1
uniprot id: P16058
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

8022:ciapin1
gene id: 8022:ciapin1
uniprot id: C1BH56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with ndor1. Interacts with chchd4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

8022:igfbp2
gene id: 8022:igfbp2
uniprot id: Q3I344
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:il19l
gene id: 8022:il19l
uniprot id: D3GMR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

8022:paqr8
gene id: 8022:paqr8
uniprot id: Q3HW38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8022:rb1
gene id: 8022:rb1
uniprot id: Q9YGE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

8022:LOC100135985
gene id: 8022:LOC100135985
uniprot id: Q7ZT58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8022:KEF44 p08
gene id: 8022:KEF44_p08
uniprot id: P48178
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

8022:LOC100136217
gene id: 8022:LOC100136217
uniprot id: Q596C5
names: Similarity
messages: Belongs to the peptidase C2 family.

8022:st8sia4
gene id: 8022:st8sia4
uniprot id: Q7T2X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8022:romo1
gene id: 8022:romo1
uniprot id: C1BGC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

8022:LOC100136637
gene id: 8022:LOC100136637
uniprot id: Q90W71
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:ngb1
gene id: 8022:ngb1
uniprot id: P59742
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the globin family.
messages: Cytoplasm
messages: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Capable of penetrating cell membranes (By similarity).
messages: Monomer.
messages: Perikaryon

8022:rnh1
gene id: 8022:rnh1
uniprot id: C1BH38
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

8022:il2rb
gene id: 8022:il2rb
uniprot id: G4RJE0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8022:tbx21
gene id: 8022:tbx21
uniprot id: E1UGZ0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8022:LOC100135791
gene id: 8022:LOC100135791
uniprot id: Q9YGF5
names: Similarity
messages: Belongs to the globin family.

8022:ralb
gene id: 8022:ralb
uniprot id: C1BGW3
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

8022:myc
gene id: 8022:myc
uniprot id: Q2L4Q4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
messages: Nucleus
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.

8022:fshb
gene id: 8022:fshb
uniprot id: Q9DG93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

8022:LOC100335037
gene id: 8022:LOC100335037
uniprot id: O13085
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

8022:comtd1
gene id: 8022:comtd1
uniprot id: C1BFU4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

8022:dad1
gene id: 8022:dad1
uniprot id: C1BF63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

8022:hsd11b2
gene id: 8022:hsd11b2
uniprot id: Q7SZK9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8022:LOC100135869
gene id: 8022:LOC100135869
uniprot id: C1BIE5
uniprot id: O73817
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).

8022:rl17
gene id: 8022:rl17
uniprot id: C1BF83
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

8022:LOC100136070
gene id: 8022:LOC100136070
uniprot id: Q8AWA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8022:irf1b
gene id: 8022:irf1b
uniprot id: Q8JIC9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8022:slc5a2
gene id: 8022:slc5a2
uniprot id: Q2A661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

8022:e3
gene id: 8022:e3
uniprot id: Q8JFG4
names: Similarity
messages: Belongs to the intermediate filament family.

8022:myd88
gene id: 8022:myd88
uniprot id: Q4LBC6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
messages: Cytoplasm
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.

8022:ambp
gene id: 8022:ambp
uniprot id: Q5F4T3
names: Similarity
names: Subcellular Location Annotation
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

8022:ift46
gene id: 8022:ift46
uniprot id: C1BGP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

8022:ifn5
gene id: 8022:ifn5
uniprot id: C1L350
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

8022:p24b
gene id: 8022:p24b
uniprot id: Q2L4Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

8022:ghitm
gene id: 8022:ghitm
uniprot id: Q1M195
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8022:il-17a
gene id: 8022:il-17a
uniprot id: Q70I21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8022:LOC100136321
gene id: 8022:LOC100136321
uniprot id: Q2I7F2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:leap-2b
gene id: 8022:leap-2b
uniprot id: Q64JE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

8022:hce23
gene id: 8022:hce23
uniprot id: C1BH58
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:htatsf1
gene id: 8022:htatsf1
uniprot id: O73631
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HTATSF1 family.
messages: Nucleus

8022:il15
gene id: 8022:il15
uniprot id: Q575Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

8022:mb
gene id: 8022:mb
uniprot id: D0FZZ1
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

8022:hsf1a
gene id: 8022:hsf1a
uniprot id: Q76M54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8022:lamtor3
gene id: 8022:lamtor3
uniprot id: C1BGB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

8022:sumo1
gene id: 8022:sumo1
uniprot id: C1BFB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

8022:cd40
gene id: 8022:cd40
uniprot id: I1SKZ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:mapip
gene id: 8022:mapip
uniprot id: C1BFT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

8022:lhb
gene id: 8022:lhb
uniprot id: Q9DG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

8022:casp9
gene id: 8022:casp9
uniprot id: Q1AP00
names: Similarity
messages: Belongs to the peptidase C14A family.

8022:wnt4a1
gene id: 8022:wnt4a1
uniprot id: G9DAQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8022:apoa-i-2
gene id: 8022:apoa-i-2
uniprot id: A0A060W2S2
uniprot id: O57524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).
messages: Secreted

8022:trub2
gene id: 8022:trub2
uniprot id: C1BEU4
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

8022:il17d
gene id: 8022:il17d
uniprot id: Q70I20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

8022:igfbp1
gene id: 8022:igfbp1
uniprot id: Q3HWG3
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:fabph
gene id: 8022:fabph
uniprot id: C1BH46
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8022:p2ry2
gene id: 8022:p2ry2
uniprot id: C1BHK5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8022:hint2
gene id: 8022:hint2
uniprot id: C1BG47
names: Similarity
messages: Belongs to the HINT family.

8022:dhdds
gene id: 8022:dhdds
uniprot id: B6ETP4
names: Similarity
messages: Belongs to the UPP synthase family.

8022:LOC100136700
gene id: 8022:LOC100136700
uniprot id: A9XEM9
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

8022:trpc1
gene id: 8022:trpc1
uniprot id: D7NVX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
messages: Membrane
messages: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

8022:nkx2.1b
gene id: 8022:nkx2.1b
uniprot id: Q58A08
names: Subcellular Location Annotation
messages: Nucleus

8022:ndufa1
gene id: 8022:ndufa1
uniprot id: C1BG57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Mitochondrion inner membrane

8022:LOC100136949
gene id: 8022:LOC100136949
uniprot id: Q8AXU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

8022:cmc2
gene id: 8022:cmc2
uniprot id: C1BES8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

8022:c7b
gene id: 8022:c7b
uniprot id: Q7T2W9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:vig1
gene id: 8022:vig1
uniprot id: O93384
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the radical SAM superfamily. RSAD2 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: By interferon type I, type II and LPS. Induced by infection with viral hemorrhagic septicemia virus (VHSV), presumably through type I interferon pathway.
messages: Endoplasmic reticulum membrane
messages: Expressed at low levels in spleen and head kidney.
messages: Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon.

8022:LOC100301728
gene id: 8022:LOC100301728
uniprot id: C1BEY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

8022:jun
gene id: 8022:jun
uniprot id: Q2L4Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

8022:rhd
gene id: 8022:rhd
uniprot id: A8QJT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cell membrane
messages: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.
messages: Membrane

8022:si:dkey-51e6.1
gene id: 8022:si:dkey-51e6.1
uniprot id: C1BGM8
names: Similarity
messages: Belongs to the janus family.

8022:tspo
gene id: 8022:tspo
uniprot id: Q7ZZV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

8022:plp
gene id: 8022:plp
uniprot id: P79826
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: Central nervous system. Highest levels in spinal cord and medulla oblongata.
messages: First expressed at hatching day, levels rapidly increase during the early postnatal period reaching a maximum by the 9th week. High levels are maintained in adults.
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. May be involved in neuron and glial cell differentiation.

8022:LOC100136775
gene id: 8022:LOC100136775
uniprot id: P79899
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:si:dkey-42i9.4
gene id: 8022:si:dkey-42i9.4
uniprot id: C1BEQ4
names: Function
names: Similarity
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.

8022:LOC100136175
gene id: 8022:LOC100136175
uniprot id: Q6X4M3
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the lin-52 family.
messages: Component of the DREAM complex.
messages: Down-regulated in the retina at smoltification, the metamorphic transformation from a parr to a molt.
messages: Expressed in the brain, liver and retina. Highly expressed in the retinal ganglion cell and inner nuclear layers at the parr stage. Expressed at a lower level in inner segments of some retinal photoreceptors.
messages: May be involved in retinal development.

8022:hba1
gene id: 8022:hba1
uniprot id: Q98974
names: Similarity
messages: Belongs to the globin family.

8022:defbl3
gene id: 8022:defbl3
uniprot id: C9WX69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

8022:LOC100135983
gene id: 8022:LOC100135983
uniprot id: Q7ZT60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

8022:catl
gene id: 8022:catl
uniprot id: C1BH60
names: Similarity
messages: Belongs to the peptidase C1 family.

8022:LOC100136077
gene id: 8022:LOC100136077
uniprot id: Q5NKF9
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

8022:sstr1b
gene id: 8022:sstr1b
uniprot id: Q5G547
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8022:nudt1
gene id: 8022:nudt1
uniprot id: C1BHM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

8022:il10
gene id: 8022:il10
uniprot id: Q6L8N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

8022:atp6v0cb
gene id: 8022:atp6v0cb
uniprot id: C1BFU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

8022:mrpl2
gene id: 8022:mrpl2
uniprot id: C1BHW7
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

8022:mcts1
gene id: 8022:mcts1
uniprot id: C1BFA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

8022:csn5
gene id: 8022:csn5
uniprot id: C1BF76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

8022:defbl1
gene id: 8022:defbl1
uniprot id: Q14QQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

8022:gbrap
gene id: 8022:gbrap
uniprot id: C1BFZ4
names: Similarity
messages: Belongs to the ATG8 family.

8022:LOC100136752
gene id: 8022:LOC100136752
uniprot id: Q91195
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystatin family.
messages: Cysteine proteinase inhibitor.
messages: Secreted

8022:rl15
gene id: 8022:rl15
uniprot id: C1BFS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

8022:imp4
gene id: 8022:imp4
uniprot id: C1BH39
names: Subcellular Location Annotation
messages: nucleolus

8022:LOC100136345
gene id: 8022:LOC100136345
uniprot id: A0SML0
names: Similarity
messages: Belongs to the OSBP family.

8022:LOC100135999
gene id: 8022:LOC100135999
uniprot id: Q8QGB0
names: Similarity
messages: Belongs to the ARTD/PARP family.

8022:LOC100136729
gene id: 8022:LOC100136729
uniprot id: P49253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PEA).
messages: Mitochondrion outer membrane

8022:ube2n
gene id: 8022:ube2n
uniprot id: C1BFZ2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8022:akirin2
gene id: 8022:akirin2
uniprot id: C8BMC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

8022:LOC100301741
gene id: 8022:LOC100301741
uniprot id: C1BF34
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.

8022:actr6
gene id: 8022:actr6
uniprot id: C1BGF8
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

8022:iscua
gene id: 8022:iscua
uniprot id: D1J6Y1
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

8022:plg
gene id: 8022:plg
uniprot id: Q5DVP8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

8022:pob
gene id: 8022:pob
uniprot id: C1BET9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

8022:med31
gene id: 8022:med31
uniprot id: C1BFD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8022:LOC100170213
gene id: 8022:LOC100170213
uniprot id: A0A060XQP6
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Calcium-binding component of otoliths, a calcium carbonate structure of the inner ear involved in hearing and balance sensing (PubMed:18410381). Binds calcium (PubMed:18410381, PubMed:28866388).
messages: Specifically expressed in otolith matrix-producing cells.
messages: The Asp/Glu-rich (acidic) region mediates binding to calcium.
messages: extracellular matrix

8022:LOC100653482
gene id: 8022:LOC100653482
uniprot id: F4NAR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:LOC100136672
gene id: 8022:LOC100136672
uniprot id: Q5G546
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8022:cd8a
gene id: 8022:cd8a
uniprot id: Q9IAL5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8022:il21
gene id: 8022:il21
uniprot id: E4W7U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

8022:cbs
gene id: 8022:cbs
uniprot id: A9Z023
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

8022:c6
gene id: 8022:c6
uniprot id: Q6H964
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:LOC100136196
gene id: 8022:LOC100136196
uniprot id: Q6UFZ5
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

8022:abcg2
gene id: 8022:abcg2
uniprot id: A8IJF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

8022:nramp-alpha
gene id: 8022:nramp-alpha
uniprot id: Q9W665
names: Similarity
messages: Belongs to the NRAMP family.

8022:ndufb1
gene id: 8022:ndufb1
uniprot id: C1BGW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8022:igfbp5
gene id: 8022:igfbp5
uniprot id: Q3HNB1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:LOC100499584
gene id: 8022:LOC100499584
uniprot id: C8BMC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

8022:p22-phox
gene id: 8022:p22-phox
uniprot id: Q60FB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

8022:LOC100379112
gene id: 8022:LOC100379112
uniprot id: A5X2V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

8022:il2
gene id: 8022:il2
uniprot id: C7AL05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

8022:emp2
gene id: 8022:emp2
uniprot id: C1BI46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

8022:LOC100499589
gene id: 8022:LOC100499589
uniprot id: C8BMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

8022:LOC100135781
gene id: 8022:LOC100135781
uniprot id: O57395
names: Subcellular Location Annotation
messages: Nucleus

8022:c8b
gene id: 8022:c8b
uniprot id: Q90X85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b sequentially binds C6, C7, C8 and multiple copies of the pore-forming subunit C9 (By similarity).
messages: Secreted

8022:c-myc
gene id: 8022:c-myc
uniprot id: Q91421
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
messages: Nucleus
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.

8022:cxcl12a
gene id: 8022:cxcl12a
uniprot id: H1ZZ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8022:psd6
gene id: 8022:psd6
uniprot id: C1BGB4
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

8022:tnfr
gene id: 8022:tnfr
uniprot id: Q7T2H3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:krt79
gene id: 8022:krt79
uniprot id: Q91219
names: Similarity
messages: Belongs to the intermediate filament family.

8022:LOC100135837
gene id: 8022:LOC100135837
uniprot id: Q5R1Y9
names: Similarity
messages: Belongs to the peptidase C2 family.

8022:KEF44 p03
gene id: 8022:KEF44_p03
uniprot id: P48176
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion inner membrane

8022:taf10
gene id: 8022:taf10
uniprot id: C1BGY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus

8022:LOC100136697
gene id: 8022:LOC100136697
uniprot id: A0T073
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: spindle

8022:KEF44 p13
gene id: 8022:KEF44_p13
uniprot id: P48174
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion inner membrane

8022:LOC100136751
gene id: 8022:LOC100136751
uniprot id: Q91194
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted
messages: Somatostatin inhibits the release of somatotropin.

8022:LOC100301659
gene id: 8022:LOC100301659
uniprot id: B8YMU0
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

8022:LOC100135808
gene id: 8022:LOC100135808
uniprot id: Q9DG94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer of an alpha and a beta chain.
messages: Secreted

8022:lyrm2
gene id: 8022:lyrm2
uniprot id: C1BG03
names: Similarity
messages: Belongs to the complex I LYR family.

8022:cct8
gene id: 8022:cct8
uniprot id: Q5DW61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

8022:hus1
gene id: 8022:hus1
uniprot id: C1BF59
names: Similarity
messages: Belongs to the HUS1 family.

8022:gsto1
gene id: 8022:gsto1
uniprot id: C1BFM5
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

8022:vatg1
gene id: 8022:vatg1
uniprot id: C1BHX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8022:nr1i2
gene id: 8022:nr1i2
uniprot id: A5A0Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8022:tnf
gene id: 8022:tnf
uniprot id: Q9DEP9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:LOC100135963
gene id: 8022:LOC100135963
uniprot id: Q804Y0
names: Similarity
messages: Belongs to the NDK family.

8022:LOC100136674
gene id: 8022:LOC100136674
uniprot id: Q49BZ2
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

8022:wt-t1a
gene id: 8022:wt-t1a
uniprot id: Q90XX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

8022:yee9
gene id: 8022:yee9
uniprot id: C1BEK3
names: Similarity
messages: Belongs to the YOS1 family.

8022:mstnb
gene id: 8022:mstnb
uniprot id: Q90ZD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

8022:rl23
gene id: 8022:rl23
uniprot id: C1BF21
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

8022:LOC100301812
gene id: 8022:LOC100301812
uniprot id: C1BFU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

8022:stat1-2
gene id: 8022:stat1-2
uniprot id: O13132
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8022:LOC100135908
gene id: 8022:LOC100135908
uniprot id: Q98T97
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

8022:il17r
gene id: 8022:il17r
uniprot id: A1IMH6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8022:cxcl13
gene id: 8022:cxcl13
uniprot id: H1ZZ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8022:cathy
gene id: 8022:cathy
uniprot id: Q64HX9
names: Similarity
messages: Belongs to the peptidase C1 family.

8022:ywhaqa
gene id: 8022:ywhaqa
uniprot id: Q6UFZ7
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

8022:nduba
gene id: 8022:nduba
uniprot id: C1BFI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

8022:LOC100136027
gene id: 8022:LOC100136027
uniprot id: Q9DEQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

8022:sodc
gene id: 8022:sodc
uniprot id: C1BFL3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

8022:tmco1
gene id: 8022:tmco1
uniprot id: C1BG63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:nipsnap2
gene id: 8022:nipsnap2
uniprot id: C1BFD5
names: Similarity
messages: Belongs to the NipSnap family.

8022:inh
gene id: 8022:inh
uniprot id: Q9DED3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

8022:if3c
gene id: 8022:if3c
uniprot id: C1BG32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Nucleus

8022:fa36a
gene id: 8022:fa36a
uniprot id: C1BGQ1
names: Similarity
messages: Belongs to the COX20 family.

8022:tsn9
gene id: 8022:tsn9
uniprot id: C1BGT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

8022:c4bp
gene id: 8022:c4bp
uniprot id: C1BGN0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:rl11
gene id: 8022:rl11
uniprot id: C1BHT3
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

8022:LOC100135863
gene id: 8022:LOC100135863
uniprot id: O42259
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).
messages: Homotetramer.
messages: Nucleus
messages: S-nitrosylation of Cys-152 leads to translocation to the nucleus.
messages: cytoskeleton
messages: cytosol

8022:LOC110520024
gene id: 8022:LOC110520024
uniprot id: O42445
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

8022:d2r1
gene id: 8022:d2r1
uniprot id: Q90WQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8022:calr3a
gene id: 8022:calr3a
uniprot id: Q6UD79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

8022:mx
gene id: 8022:mx
uniprot id: Q91192
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By polyinosinic-polycytidylic acid (poly I:C) and viral haemorrhagic septicaemia virus (VHSV) strain 07.71 in muscle, head kidney, spleen and liver.
messages: Cytoplasm
messages: Does not inhibit strain RB-1 of the fish pathogen, infectious hematopoietic necrosis virus (IHNV).

8022:gp91phox
gene id: 8022:gp91phox
uniprot id: Q60FB9
names: Subcellular Location Annotation
messages: Membrane

8022:rpl9
gene id: 8022:rpl9
uniprot id: C1BEP9
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

8022:rs4x
gene id: 8022:rs4x
uniprot id: C1BFS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

8022:LOC100135986
gene id: 8022:LOC100135986
uniprot id: Q8AYJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

8022:LOC100136245
gene id: 8022:LOC100136245
uniprot id: Q64HW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

8022:sys1
gene id: 8022:sys1
uniprot id: C1BFK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

8022:gh1
gene id: 8022:gh1
uniprot id: P09538
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.
messages: Secreted

8022:LOC100136761
gene id: 8022:LOC100136761
uniprot id: P87370
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome

8022:lep
gene id: 8022:lep
uniprot id: B0M1K7
names: Similarity
messages: Belongs to the leptin family.

8022:zp2.3
gene id: 8022:zp2.3
uniprot id: Q9I9M7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:LOC100135882
gene id: 8022:LOC100135882
uniprot id: Q9W6B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

8022:tmek
gene id: 8022:tmek
uniprot id: Q53HX4
names: Similarity
messages: Belongs to the protein kinase superfamily.

8022:cyp2k4
gene id: 8022:cyp2k4
uniprot id: O93297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

8022:serping1
gene id: 8022:serping1
uniprot id: Q70W32
names: Similarity
messages: Belongs to the serpin family.

8022:iscub
gene id: 8022:iscub
uniprot id: H6SG24
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

8022:irf3
gene id: 8022:irf3
uniprot id: F9UKT9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8022:if5
gene id: 8022:if5
uniprot id: C1BFP9
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

8022:ctsc
gene id: 8022:ctsc
uniprot id: Q64HY0
names: Similarity
messages: Belongs to the peptidase C1 family.

8022:cacna1b
gene id: 8022:cacna1b
uniprot id: Q7T1M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

8022:if4ea
gene id: 8022:if4ea
uniprot id: C1BFN1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

8022:otomp
gene id: 8022:otomp
uniprot id: Q9IBF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transferrin family.
messages: Expressed in the sacculus during the day.
messages: Interacts with OTOL1.
messages: Required for normal otolith growth and deposition of otolin-1 in the otolith.
messages: Secreted

8022:si:dkey-251i10.1
gene id: 8022:si:dkey-251i10.1
uniprot id: B9VQA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

8022:LOC100136156
gene id: 8022:LOC100136156
uniprot id: Q8JFN5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:rpb7
gene id: 8022:rpb7
uniprot id: C1BIG7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

8022:LOC100136290
gene id: 8022:LOC100136290
uniprot id: Q91215
names: Subcellular Location Annotation
messages: Nucleus

8022:hn1
gene id: 8022:hn1
uniprot id: C1BEH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

8022:LOC100301636
gene id: 8022:LOC100301636
uniprot id: B5AXN7
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

8022:rbtstat3
gene id: 8022:rbtstat3
uniprot id: O13133
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8022:capn2
gene id: 8022:capn2
uniprot id: Q672G9
names: Similarity
messages: Belongs to the peptidase C2 family.

8022:4ebp2
gene id: 8022:4ebp2
uniprot id: C1BHL7
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

8022:ndufa8
gene id: 8022:ndufa8
uniprot id: C1BF81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

8022:pm14
gene id: 8022:pm14
uniprot id: C1BEN6
names: Subcellular Location Annotation
messages: Nucleus

8022:il1rl1
gene id: 8022:il1rl1
uniprot id: M1ZJW4
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8022:LOC100499582
gene id: 8022:LOC100499582
uniprot id: C7S8F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

8022:LOC100136004
gene id: 8022:LOC100136004
uniprot id: Q8QFP0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

8022:LOC100136162
gene id: 8022:LOC100136162
uniprot id: Q6YLY1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

8022:yt6j
gene id: 8022:yt6j
uniprot id: C1BFY2
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

8022:LOC101268919
gene id: 8022:LOC101268919
uniprot id: G9B9Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8022:LOC100305204
gene id: 8022:LOC100305204
uniprot id: C1BH52
names: Similarity
messages: Belongs to the HEBP family.

8022:wt-t1b
gene id: 8022:wt-t1b
uniprot id: Q90XX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

8022:LOC100136741
gene id: 8022:LOC100136741
uniprot id: Q02815
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling.

8022:LOC100136317
gene id: 8022:LOC100136317
uniprot id: Q2I7F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane
messages: Secreted

8022:LOC100329196
gene id: 8022:LOC100329196
uniprot id: D0R0G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

8022:gnpi
gene id: 8022:gnpi
uniprot id: C1BI75
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

8022:n4wbp5
gene id: 8022:n4wbp5
uniprot id: Q5F4T2
names: Subcellular Location Annotation
messages: Membrane

8022:ucp2b
gene id: 8022:ucp2b
uniprot id: Q2PXW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8022:gcg2
gene id: 8022:gcg2
uniprot id: Q91189
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
messages: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
messages: Secreted

8022:LOC100136065
gene id: 8022:LOC100136065
uniprot id: Q90W12
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: clathrin-coated pit

8022:serpinf2
gene id: 8022:serpinf2
uniprot id: D9UB76
names: Similarity
messages: Belongs to the serpin family.

8022:ywhah
gene id: 8022:ywhah
uniprot id: Q6UFZ0
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

8022:gtf2h5
gene id: 8022:gtf2h5
uniprot id: C1BEZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

8022:mmp
gene id: 8022:mmp
uniprot id: Q9DEE0
names: Similarity
messages: Belongs to the peptidase M10A family.

8022:cygb
gene id: 8022:cygb
uniprot id: Q802S6
names: Similarity
messages: Belongs to the globin family.

8022:bet1l
gene id: 8022:bet1l
uniprot id: C1BGE7
names: Subcellular Location Annotation
messages: Membrane

8022:nell2b
gene id: 8022:nell2b
uniprot id: C5JA74
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:tpt1
gene id: 8022:tpt1
uniprot id: E7BBH8
names: Similarity
messages: Belongs to the TCTP family.

8022:shbgb
gene id: 8022:shbgb
uniprot id: A5JUT5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:sf3b5
gene id: 8022:sf3b5
uniprot id: C1BFG0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

8022:LOC100499585
gene id: 8022:LOC100499585
uniprot id: C8BMC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

8022:e1
gene id: 8022:e1
uniprot id: Q90W76
names: Similarity
messages: Belongs to the intermediate filament family.

8022:LOC100135953
gene id: 8022:LOC100135953
uniprot id: Q98TT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

8022:ifn2
gene id: 8022:ifn2
uniprot id: Q70G08
names: Subcellular Location Annotation
messages: Secreted

8022:ru1c
gene id: 8022:ru1c
uniprot id: C1BGQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

8022:cf166
gene id: 8022:cf166
uniprot id: C1BI08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

8022:LOC100305255
gene id: 8022:LOC100305255
uniprot id: C1BHQ9
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

8022:slc9a2
gene id: 8022:slc9a2
uniprot id: A4GWV1
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

8022:rl21
gene id: 8022:rl21
uniprot id: C1BFU1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

8022:LOC100301637
gene id: 8022:LOC100301637
uniprot id: B5AYD7
names: Similarity
messages: Belongs to the peptidase A1 family.

8022:pparab
gene id: 8022:pparab
uniprot id: E2IH97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8022:gemin2
gene id: 8022:gemin2
uniprot id: C1BFX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

8022:prlra
gene id: 8022:prlra
uniprot id: Q9DE08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

8022:LOC100136147
gene id: 8022:LOC100136147
uniprot id: A7WNH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

8022:shbg
gene id: 8022:shbg
uniprot id: Q2WFI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:mtnr1aa
gene id: 8022:mtnr1aa
uniprot id: Q9PT20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.
messages: Membrane

8022:epd
gene id: 8022:epd
uniprot id: P28770
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ependymin family.
messages: Binds calcium through the terminal sialic acids.
messages: EPDs are synthesized in the meninx and secreted in the cerebrospinal fluid.
messages: May play a role in neural plasticity. May be involved during axon regeneration.
messages: Secreted

8022:rs5
gene id: 8022:rs5
uniprot id: C1BEL7
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

8022:LOC100136257
gene id: 8022:LOC100136257
uniprot id: Q1M160
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

8022:nr1h3
gene id: 8022:nr1h3
uniprot id: B8Y3M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8022:tnf-alpha
gene id: 8022:tnf-alpha
uniprot id: Q9I976
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:canb1
gene id: 8022:canb1
uniprot id: C1BF28
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

8022:pparb
gene id: 8022:pparb
uniprot id: E2IH98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

8022:LOC100135818
gene id: 8022:LOC100135818
uniprot id: Q805B7
names: Function
names: Similarity
messages: Belongs to the calcitonin family.
messages: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

8022:cnp-1-2
gene id: 8022:cnp-1-2
uniprot id: Q8AXR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the natriuretic peptide family.
messages: Exhibits natriuretic and vasodepressor activity. Has a cGMP-stimulating activity (By similarity).
messages: Expressed in brain and to a low extent in atrium.
messages: Secreted

8022:adcyap1
gene id: 8022:adcyap1
uniprot id: Q98SP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

8022:ndufc2
gene id: 8022:ndufc2
uniprot id: C1BGY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

8022:smad3
gene id: 8022:smad3
uniprot id: C1BH24
names: Subcellular Location Annotation
messages: Nucleus

8022:LOC100136621
gene id: 8022:LOC100136621
uniprot id: A0A060YDJ7
uniprot id: Q98SN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
messages: Membrane
messages: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in pronephric kidney tubule development (By similarity).

8022:eif3m
gene id: 8022:eif3m
uniprot id: C1BH36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8022:rl7
gene id: 8022:rl7
uniprot id: C1BHP6
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

8022:ywhaba
gene id: 8022:ywhaba
uniprot id: A0A060XH76
uniprot id: Q6UFZ9
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Expressed in brain, gill, heart, intestine, kidney, liver, ovary, skin, spleen and testis.
messages: Expressed throughout development. Expressed in the neural crest, eyes, yolk syncytium, tail bud and caudal somites of somitic embryos. Expressed in the neural crest, gill covers and gill arches, and the pectoral fins of post-somitic embryos.
messages: Homodimer, and heterodimer with other family members.
messages: Repressed under stress conditions such as netting.

8022:zgc:112271
gene id: 8022:zgc:112271
uniprot id: C1BEL3
names: Similarity
messages: Belongs to the BolA/IbaG family.

8022:thg1l
gene id: 8022:thg1l
uniprot id: C1BI96
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

8022:k13
gene id: 8022:k13
uniprot id: Q8JFQ6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Expressed in epidermis.
messages: Heterotetramer of two type I and two type II keratins.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
messages: Type 1 keratin (Probable). May maintain oral mucosal cell homeostasis and tissue organization in response to mechanical stress (By similarity).

8022:tmm85
gene id: 8022:tmm85
uniprot id: C1BEW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:ccka
gene id: 8022:ccka
uniprot id: Q9YGE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

8022:cd28
gene id: 8022:cd28
uniprot id: Q5EPK5
names: Subcellular Location Annotation
messages: Membrane

8022:fshr
gene id: 8022:fshr
uniprot id: Q71MM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

8022:LOC100305168
gene id: 8022:LOC100305168
uniprot id: C1BGS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

8022:glud1
gene id: 8022:glud1
uniprot id: Q8JHY1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

8022:cyp17a1
gene id: 8022:cyp17a1
uniprot id: P30437
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.
messages: Membrane
messages: Regulated predominantly by intracellular cAMP levels.

8022:rs13
gene id: 8022:rs13
uniprot id: C1BG76
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

8022:rtnanos3
gene id: 8022:rtnanos3
uniprot id: M1V8T8
names: Similarity
messages: Belongs to the nanos family.

8022:LOC100136727
gene id: 8022:LOC100136727
uniprot id: P12027
names: Function
names: Miscellaneous
names: PTM
names: Tissue Specificity
messages: Cortical alveoli of immature ovaries.
messages: In response to egg activation, PSGP is discharged by exocytosis into the perivitelline space, where it undergoes rapid proteolysis into glycotridecapeptides. During fertilization and/or early development the glycotridecapeptides prevent polyspermy or are involved in the formation of a fertilization membrane.
messages: Most sialic acid residues exist in the form of polysialyl groups partly capped with deaminoneuraminic acid.
messages: Multiple genes for PSGP are transcribed into multiple mRNAs containing diverged numbers of repeating units.
messages: The core of the PSGP protein contains an average of 25 exact tandem repeats of the same glycotridecapeptide, where the Ser and the Thr residues are attachment sites of a polysialylglycan chain.

8022:ncx
gene id: 8022:ncx
uniprot id: Q9PT19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

8022:nme4
gene id: 8022:nme4
uniprot id: C0KIP7
names: Similarity
messages: Belongs to the NDK family.

8022:polr3k
gene id: 8022:polr3k
uniprot id: C1BEQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

8022:tebp
gene id: 8022:tebp
uniprot id: Q5UTE8
names: Similarity
messages: Belongs to the p23/wos2 family.

8022:if36
gene id: 8022:if36
uniprot id: C1BGN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Nucleus

8022:pnpo
gene id: 8022:pnpo
uniprot id: C1BH17
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

8022:gnrh3
gene id: 8022:gnrh3
uniprot id: Q90VY3
uniprot id: Q90W09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins.

8022:LOC100642186
gene id: 8022:LOC100642186
uniprot id: F9W2Z4
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.
messages: tight junction

8022:rbhce1
gene id: 8022:rbhce1
uniprot id: D2YYG2
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:star
gene id: 8022:star
uniprot id: A0A060WBZ2
uniprot id: Q9DEB4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

8022:cuta
gene id: 8022:cuta
uniprot id: C1BHH7
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

8022:crf-bp
gene id: 8022:crf-bp
uniprot id: Q5J878
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

8022:cd3e
gene id: 8022:cd3e
uniprot id: D0VFH8
names: Subcellular Location Annotation
messages: Membrane

8022:LOC100136197
gene id: 8022:LOC100136197
uniprot id: Q6UFZ4
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

8022:LOC100136153
gene id: 8022:LOC100136153
uniprot id: Q8UUY8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).
messages: Cell membrane
messages: Highly expressed in the liver and red and white muscle, with lower levels of expression in the gills, heart, kidney and spleen.
messages: Lacks the regulatory protein kinase A phosphorylation sites within the G-protein binding domain that mediate desensitization and are present in mammalian homologs.

8022:ghrl
gene id: 8022:ghrl
uniprot id: Q76IQ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the motilin family.
messages: Ghrelin-20 and Ghrelin-23 are amidated. In some cases, Gly-50 is retained after dibasic amino acid cleavage, to produce non-amidated Ghrelin-21 and Ghrelin-24.
messages: Highest levels in the stomach. Moderate levels in the brain, hypothalamus and intestinal tracts.
messages: Ligand for growth hormone secretagogue receptor type 1 (GHSR). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity). Induces the release of growth hormone from the pituitary.
messages: O-octanoylated by GOAT/MBOAT4 (By similarity). O-octanoylation or O-decanoylation is essential for activity. The O-decanoylated forms differ in the length of the carbon backbone of the carboxylic acid forming an ester bond with Ser-29 (By similarity). The majority of trout ghrelin is Ghrelin-20 modified with unsaturated decanoic acid (PubMed:12970156).
messages: Secreted

8022:cpt1
gene id: 8022:cpt1
uniprot id: Q8AYL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

8022:tcf7
gene id: 8022:tcf7
uniprot id: G8GVE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

8022:rpl7l1
gene id: 8022:rpl7l1
uniprot id: C1BG77
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

8022:srp19
gene id: 8022:srp19
uniprot id: C1BI41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

8022:m17
gene id: 8022:m17
uniprot id: D0R0G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

8022:gs02
gene id: 8022:gs02
uniprot id: Q8JI33
names: Similarity
messages: Belongs to the glutamine synthetase family.

8022:opn1sw2
gene id: 8022:opn1sw2
uniprot id: Q7ZT59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

8022:capn1
gene id: 8022:capn1
uniprot id: Q672H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

8022:cmas
gene id: 8022:cmas
uniprot id: Q90WG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid.
messages: Expressed in testis, ovary and liver.
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.
messages: Nucleus

8022:apooa
gene id: 8022:apooa
uniprot id: C1BH23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

8022:ndufb7
gene id: 8022:ndufb7
uniprot id: C1BGK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

8022:tp53
gene id: 8022:tp53
uniprot id: P25035
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Nucleus

8022:rpb10
gene id: 8022:rpb10
uniprot id: C1BGM1
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

8022:ruxf
gene id: 8022:ruxf
uniprot id: C1BEZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

8022:cebpb
gene id: 8022:cebpb
uniprot id: Q7SZH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

8022:cyp1b1
gene id: 8022:cyp1b1
uniprot id: D3XFH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8022:rhgb
gene id: 8022:rhgb
uniprot id: A8QJ79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cell membrane
messages: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.
messages: Membrane

8022:rbp2
gene id: 8022:rbp2
uniprot id: Q71B03
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8022:ca4
gene id: 8022:ca4
uniprot id: Q6R4A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cell membrane
messages: Interacts with SLC4A4.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

8022:ntf2
gene id: 8022:ntf2
uniprot id: C1BI16
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

8022:srp09
gene id: 8022:srp09
uniprot id: C1BFM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

8022:s1
gene id: 8022:s1
uniprot id: Q90YH3
names: Similarity
messages: Belongs to the intermediate filament family.

8022:sat1
gene id: 8022:sat1
uniprot id: C1BF43
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Homodimer.

8022:arf4
gene id: 8022:arf4
uniprot id: C1BFL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

8022:mrps33
gene id: 8022:mrps33
uniprot id: Q6BDB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

8022:c9
gene id: 8022:c9
uniprot id: Q4QZ25
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted
messages: Target cell membrane

8022:gng12a
gene id: 8022:gng12a
uniprot id: C1BIC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8022:hba4
gene id: 8022:hba4
uniprot id: C1BF11
names: Similarity
messages: Belongs to the globin family.

8022:hbb1
gene id: 8022:hbb1
uniprot id: C1BEX8
names: Similarity
messages: Belongs to the globin family.

8022:nhe3b
gene id: 8022:nhe3b
uniprot id: B6VDZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

8022:tyrobp
gene id: 8022:tyrobp
uniprot id: E7FKX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAP10 family.
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

8022:casp8
gene id: 8022:casp8
uniprot id: G8BLB6
names: Similarity
messages: Belongs to the peptidase C14A family.

8022:rs19
gene id: 8022:rs19
uniprot id: C1BEI6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

8022:hcn2
gene id: 8022:hcn2
uniprot id: A8E2S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8022:cd34a
gene id: 8022:cd34a
uniprot id: H1ZRI4
names: Subcellular Location Annotation
messages: Membrane

8022:cd63
gene id: 8022:cd63
uniprot id: Q64HX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

8022:arpc3
gene id: 8022:arpc3
uniprot id: C1BFF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

8022:LOC100136244
gene id: 8022:LOC100136244
uniprot id: Q64HW8
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

8022:LOC100136215
gene id: 8022:LOC100136215
uniprot id: Q6R5C2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.
messages: Membrane

8022:LOC100305231
gene id: 8022:LOC100305231
uniprot id: C1BHG3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

8022:pla2g12a
gene id: 8022:pla2g12a
uniprot id: C1BFP2
names: Subcellular Location Annotation
messages: Secreted

8022:abracl
gene id: 8022:abracl
uniprot id: C1BEZ5
names: Similarity
messages: Belongs to the costars family.

8022:fa18b
gene id: 8022:fa18b
uniprot id: C1BF85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

8022:itpa
gene id: 8022:itpa
uniprot id: C1BEV3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

8022:dpm3
gene id: 8022:dpm3
uniprot id: C1BHD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

8022:tcbp2
gene id: 8022:tcbp2
uniprot id: L0R4B0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:nr5a2
gene id: 8022:nr5a2
uniprot id: Q2PGF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

8022:tcp4
gene id: 8022:tcp4
uniprot id: C1BG53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Nucleus

8022:cck-n
gene id: 8022:cck-n
uniprot id: O93606
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

8022:actriib
gene id: 8022:actriib
uniprot id: D9IG62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

8022:LOC100136183
gene id: 8022:LOC100136183
uniprot id: Q6VYM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8022:cd18
gene id: 8022:cd18
uniprot id: A0ZXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

8022:rtst6galnac
gene id: 8022:rtst6galnac
uniprot id: Q7T2X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8022:rho
gene id: 8022:rho
uniprot id: Q7ZT62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

8022:ntl
gene id: 8022:ntl
uniprot id: C6KJ78
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8022:il8r
gene id: 8022:il8r
uniprot id: Q90ZZ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8022:LOC101268929
gene id: 8022:LOC101268929
uniprot id: G9C072
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8022:cpsf5
gene id: 8022:cpsf5
uniprot id: C1BGE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

8022:calcb
gene id: 8022:calcb
uniprot id: Q805B6
names: Function
names: Similarity
messages: Belongs to the calcitonin family.
messages: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

8022:gs01
gene id: 8022:gs01
uniprot id: Q8JI34
names: Similarity
messages: Belongs to the glutamine synthetase family.

8022:adipor1a
gene id: 8022:adipor1a
uniprot id: G9C071
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

8022:cyp1a3
gene id: 8022:cyp1a3
uniprot id: Q9PRH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8022:chmp3
gene id: 8022:chmp3
uniprot id: C1BGP2
names: Similarity
messages: Belongs to the SNF7 family.

8022:gk
gene id: 8022:gk
uniprot id: O93314
names: Similarity
messages: Belongs to the hexokinase family.

8022:LOC100136692
gene id: 8022:LOC100136692
uniprot id: Q09IZ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

8022:LOC100305228
gene id: 8022:LOC100305228
uniprot id: C1BHF2
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

8022:ifng
gene id: 8022:ifng
uniprot id: Q5QSL2
names: Similarity
messages: Belongs to the type II (or gamma) interferon family.

8022:psb4
gene id: 8022:psb4
uniprot id: C1BGS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

8022:dss1
gene id: 8022:dss1
uniprot id: C1BEV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

8022:hsf1
gene id: 8022:hsf1
uniprot id: Q76M53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

8022:KEF44 p09
gene id: 8022:KEF44_p09
uniprot id: P68528
uniprot id: Q1L037
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Mitochondrion membrane

8022:pvalb2
gene id: 8022:pvalb2
uniprot id: E0WDA3
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8022:myog
gene id: 8022:myog
uniprot id: Q91207
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8022:rtn4
gene id: 8022:rtn4
uniprot id: Q4FZ68
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:rln3a
gene id: 8022:rln3a
uniprot id: H1AFL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

8022:dio2
gene id: 8022:dio2
uniprot id: Q78CG1
uniprot id: Q90VZ0
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

8022:LOC100136200
gene id: 8022:LOC100136200
uniprot id: Q6UFZ1
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

8022:LOC100136778
gene id: 8022:LOC100136778
uniprot id: O57607
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Expressed in all tissues examined, including epidermal keratinocytes, tongue mucosa, corneal epithelium, Meninges cells, epidermal goblet and Merkel cells, gill mucosa, basal cells of gill secondary lamellae, hepatocytes and bile canaliculi, bile duct, intestinal mucosa, blood vessel endothelial and muscle cells, interstitial cells, fibroblasts, scale-associated cells, ovary stroma and follicle, optic nerve glia, eye ciliary body, chondrocytes and kidney tubules.
messages: Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8 (By similarity).
messages: Phosphorylated.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
messages: When phosphorylated, plays a role in filament reorganization.

8022:mos
gene id: 8022:mos
uniprot id: A9QXB2
names: Similarity
messages: Belongs to the protein kinase superfamily.

8022:LOC100335038
gene id: 8022:LOC100335038
uniprot id: A0A060YK59
uniprot id: P51468
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arrestin family.
messages: Cytoplasm

8022:LOC100136772
gene id: 8022:LOC100136772
uniprot id: Q04618
names: Caution
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acetylation of beta-endorphin occurs in a tissue-specific manner.
messages: Belongs to the POMC family.
messages: Beta-endorphin: Endogenous orexigenic opiate.
messages: Endogenous opiate.
messages: Expressed only in sexually active fish.
messages: It is uncertain whether Met-1 or Met-15 is the initiator.
messages: Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Pituitary and hypothalamus of adult diploid animals.
messages: Secreted
messages: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
messages: Stimulates the adrenal glands to release cortisol.

8022:rpf1
gene id: 8022:rpf1
uniprot id: C1BEQ1
names: Subcellular Location Annotation
messages: nucleolus

8022:KEF44 p10
gene id: 8022:KEF44_p10
uniprot id: E2JDK3
uniprot id: P48171
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16 (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

8022:lt-b2
gene id: 8022:lt-b2
uniprot id: Q1JTL6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:ctsla
gene id: 8022:ctsla
uniprot id: Q90WC2
names: Similarity
messages: Belongs to the peptidase C1 family.

8022:gpx1
gene id: 8022:gpx1
uniprot id: Q5UTE7
uniprot id: W8W0Y8
names: Similarity
messages: Belongs to the glutathione peroxidase family.

8022:fabp7b
gene id: 8022:fabp7b
uniprot id: G9HXN8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

8022:cxcl8c
gene id: 8022:cxcl8c
uniprot id: H1ZZ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8022:LOC100136771
gene id: 8022:LOC100136771
uniprot id: Q04617
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acetylation of beta-endorphin occurs in a tissue-specific manner.
messages: Belongs to the POMC family.
messages: Beta-endorphin: Endogenous orexigenic opiate.
messages: C-terminal peptide 1 and C-terminal peptide 2 are detected in the anterior part of the nucleus lateralis tuberis of hypothalamus, in dorsal hypothalamus, thalamus, telencephalon, optic tectum and medulla oblongata (at protein level). Expressed in pituitary and hypothalamus of adult diploid animals, and hypothalamus of triploid and ovulated female trout.
messages: Endogenous opiate.
messages: Expressed in sexually active or inactive fish.
messages: Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Secreted
messages: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
messages: Stimulates the adrenal glands to release cortisol.

8022:erb2
gene id: 8022:erb2
uniprot id: Q0H3B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8022:il6
gene id: 8022:il6
uniprot id: Q0GGL7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: Expressed in spleen, gill and gastrointestinal tract, ovary and brain. Highest expression in ovary.
messages: Secreted
messages: by LPS.

8022:arcn1a
gene id: 8022:arcn1a
uniprot id: B9WPL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

8022:cq032
gene id: 8022:cq032
uniprot id: C1BG94
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:il-18
gene id: 8022:il-18
uniprot id: Q70PK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Secreted

8022:gp137
gene id: 8022:gp137
uniprot id: C1BGE5
names: Similarity
messages: Belongs to the caprin family.

8022:tppc5
gene id: 8022:tppc5
uniprot id: C1BHU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

8022:mra
gene id: 8022:mra
uniprot id: Q5WP02
names: Subcellular Location Annotation
messages: Nucleus

8022:nbc
gene id: 8022:nbc
uniprot id: Q8AYH7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8022:LOC100136690
gene id: 8022:LOC100136690
uniprot id: Q09IZ2
names: Similarity
messages: Belongs to the cyclin family.

8022:cyp1c2
gene id: 8022:cyp1c2
uniprot id: D3XFH9
names: Similarity
messages: Belongs to the cytochrome P450 family.

8022:LOC100135945
gene id: 8022:LOC100135945
uniprot id: Q98TW6
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8022:LOC100653466
gene id: 8022:LOC100653466
uniprot id: F2WVP7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8022:LOC100301685
gene id: 8022:LOC100301685
uniprot id: C1BEJ1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8022:olah
gene id: 8022:olah
uniprot id: C1BFC1
names: Similarity
messages: Belongs to the thioesterase family.

8022:LOC100136343
gene id: 8022:LOC100136343
uniprot id: Q1HG86
names: Similarity
messages: Belongs to the TGF-beta family.

8022:LOC100136606
gene id: 8022:LOC100136606
uniprot id: Q9PT36
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8022:LOC100135894
gene id: 8022:LOC100135894
uniprot id: Q7SZV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

8022:sdy
gene id: 8022:sdy
uniprot id: I7GVT3
names: Subcellular Location Annotation
messages: Nucleus

8022:atf1
gene id: 8022:atf1
uniprot id: Q3LTM7
names: Subcellular Location Annotation
messages: Nucleus

8022:slc30a1a
gene id: 8022:slc30a1a
uniprot id: Q49LH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

8022:LOC100136105
gene id: 8022:LOC100136105
uniprot id: Q2PDG0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:rl31
gene id: 8022:rl31
uniprot id: C1BF51
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

8022:slc11a2
gene id: 8022:slc11a2
uniprot id: Q9W666
names: Similarity
messages: Belongs to the NRAMP family.

8022:cd40l
gene id: 8022:cd40l
uniprot id: A9XBM0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:spcs1
gene id: 8022:spcs1
uniprot id: C1BIF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:rs10
gene id: 8022:rs10
uniprot id: C1BFN5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

8022:LOC100136294
gene id: 8022:LOC100136294
uniprot id: P79822
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8022:fut9
gene id: 8022:fut9
uniprot id: Q70G09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

8022:mo4l1
gene id: 8022:mo4l1
uniprot id: C1BGS4
names: Subcellular Location Annotation
messages: Nucleus

8022:ndufa2
gene id: 8022:ndufa2
uniprot id: C1BI52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8022:psb2
gene id: 8022:psb2
uniprot id: C1BH71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

8022:bnip3
gene id: 8022:bnip3
uniprot id: C1BER1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

8022:psmd8
gene id: 8022:psmd8
uniprot id: C1BI19
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

8022:tlr5
gene id: 8022:tlr5
uniprot id: Q7ZT81
names: Similarity
messages: Belongs to the Toll-like receptor family.

8022:cdx1
gene id: 8022:cdx1
uniprot id: Q6T5L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

8022:cfbl
gene id: 8022:cfbl
uniprot id: Q9YGE7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:LOC100136736
gene id: 8022:LOC100136736
uniprot id: P18288
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
messages: Belongs to the tubulin family.
messages: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis (By similarity). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction (By similarity).
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity).
messages: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of polyglycylation is still unclear.
messages: Testis specific.
messages: The MREC motif may be critical for tubulin autoregulation.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: Tyrosination promotes microtubule interaction with CAP-Gly microtubule plus-end tracking proteins. Tyrosinated tubulins regulate the initiation of dynein-driven motility.
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (MATCAP, VASH1 or VASH2) and tubulin tyrosine ligase (TTL), respectively.
messages: cytoskeleton

8022:ndua6
gene id: 8022:ndua6
uniprot id: C1BF97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8022:LOC100136590
gene id: 8022:LOC100136590
uniprot id: Q9YGF6
names: Similarity
messages: Belongs to the globin family.

8022:LOC100499588
gene id: 8022:LOC100499588
uniprot id: C8BMC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

8022:ipyr
gene id: 8022:ipyr
uniprot id: C1BI86
names: Similarity
messages: Belongs to the PPase family.

8022:rps20
gene id: 8022:rps20
uniprot id: Q90YH0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

8022:LOC100136256
gene id: 8022:LOC100136256
uniprot id: Q1M162
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

8022:aakb1
gene id: 8022:aakb1
uniprot id: C1BHK9
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

8022:if2b
gene id: 8022:if2b
uniprot id: C1BGJ1
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

8022:rhbg2a
gene id: 8022:rhbg2a
uniprot id: B6D1P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cell membrane
messages: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.
messages: Membrane

8022:hs020
gene id: 8022:hs020
uniprot id: C1BEK8
names: Similarity
messages: Belongs to the APC15 family.

8022:LOC100135903
gene id: 8022:LOC100135903
uniprot id: Q9IA29
names: Subcellular Location Annotation
messages: Membrane

8022:LOC100135907
gene id: 8022:LOC100135907
uniprot id: Q9I9M6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

8022:atp1a3
gene id: 8022:atp1a3
uniprot id: Q6VYM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8022:LOC100136665
gene id: 8022:LOC100136665
uniprot id: Q5SE05
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: dendrite

8022:LOC100135993
gene id: 8022:LOC100135993
uniprot id: Q8JJ23
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8022:npc2
gene id: 8022:npc2
uniprot id: C1BGA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

8022:LOC100301653
gene id: 8022:LOC100301653
uniprot id: B7SFF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

8022:aass
gene id: 8022:aass
uniprot id: Q5XLU9
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

8022:il17c2
gene id: 8022:il17c2
uniprot id: D4HTR9
names: Similarity
messages: Belongs to the IL-17 family.

8022:KEF44 p05
gene id: 8022:KEF44_p05
uniprot id: P69302
uniprot id: Q1L033
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

8022:cast
gene id: 8022:cast
uniprot id: Q49BZ3
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

8022:bdkrb1
gene id: 8022:bdkrb1
uniprot id: Q1M198
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8022:iip
gene id: 8022:iip
uniprot id: Q8QFM4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8022:wu:fj39g12
gene id: 8022:wu:fj39g12
uniprot id: A0A060XWG0
uniprot id: Q8AXR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the natriuretic peptide family.
messages: Exhibits natriuretic and vasodepressant activity. Has a cGMP-stimulating activity.
messages: Expressed in brain and to a low extent in atrium.
messages: Secreted

8022:LOC100505416
gene id: 8022:LOC100505416
uniprot id: E2IH99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

8022:LOC100135991
gene id: 8022:LOC100135991
uniprot id: Q8JFR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

8022:dlc2
gene id: 8022:dlc2
uniprot id: Q9YGF3
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8022:cxcr3.1
gene id: 8022:cxcr3.1
uniprot id: A4F344
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

8022:LOC100136664
gene id: 8022:LOC100136664
uniprot id: Q1M194
names: Similarity
messages: Belongs to the MARCKS family.

8022:atp5f1c
gene id: 8022:atp5f1c
uniprot id: C0KIP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

8022:gbrl2
gene id: 8022:gbrl2
uniprot id: C1BH53
names: Similarity
messages: Belongs to the ATG8 family.

8022:abcc2
gene id: 8022:abcc2
uniprot id: Q009X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

8022:cyp2k5
gene id: 8022:cyp2k5
uniprot id: Q9IAT1
names: Similarity
messages: Belongs to the cytochrome P450 family.

8022:tera
gene id: 8022:tera
uniprot id: C1BF87
names: Similarity
messages: Belongs to the AAA ATPase family.

8022:rs11
gene id: 8022:rs11
uniprot id: C1BFE9
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

8022:gnrh1
gene id: 8022:gnrh1
uniprot id: Q9W7G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins.

8022:LOC100135811
gene id: 8022:LOC100135811
uniprot id: O93484
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the fibrillar collagen family.
messages: Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
messages: Trimers of one alpha 2(I) and two alpha 1(I) chains.
messages: Type I collagen is a member of group I collagen (fibrillar forming collagen).
messages: extracellular matrix

8022:LOC100170209
gene id: 8022:LOC100170209
uniprot id: B2KL82
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

8022:il-1ra
gene id: 8022:il-1ra
uniprot id: Q575Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

8022:crj1a
gene id: 8022:crj1a
uniprot id: C1BFR5
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

8022:polr1d
gene id: 8022:polr1d
uniprot id: C1BEM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

8022:akirin1
gene id: 8022:akirin1
uniprot id: C8BMB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

8022:ccdc58
gene id: 8022:ccdc58
uniprot id: C1BHF5
names: Similarity
messages: Belongs to the MIX23 family.

8022:parapinopsina
gene id: 8022:parapinopsina
uniprot id: Q75R38
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

8022:LOC101867532
gene id: 8022:LOC101867532
uniprot id: G9B9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8022:ar-beta
gene id: 8022:ar-beta
uniprot id: O93245
names: Subcellular Location Annotation
messages: Nucleus

8022:med21
gene id: 8022:med21
uniprot id: C1BFI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

8022:mif
gene id: 8022:mif
uniprot id: Q0ZBR8
names: Similarity
messages: Belongs to the MIF family.

8022:opi-2
gene id: 8022:opi-2
uniprot id: Q8AX91
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:dimt1l
gene id: 8022:dimt1l
uniprot id: C1BHG9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

8022:tshba
gene id: 8022:tshba
uniprot id: A0A060VXM2
uniprot id: P37240
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
messages: Indispensable for the control of thyroid structure and metabolism. May play some role in the biological processes of the immature fishes.
messages: It is uncertain whether Met-1 or Met-7 is the initiator.
messages: Pituitary gland. Higher levels seen in immature fishes than the mature fishes.
messages: Secreted

8022:pax-5
gene id: 8022:pax-5
uniprot id: A8DB63
names: Subcellular Location Annotation
messages: Nucleus

8022:gale
gene id: 8022:gale
uniprot id: C1BI55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

8022:cpi1
gene id: 8022:cpi1
uniprot id: Q64HX6
names: Similarity
messages: Belongs to the cystatin family.

8022:ifm3
gene id: 8022:ifm3
uniprot id: C1BI59
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8022:sar1a
gene id: 8022:sar1a
uniprot id: C1BG51
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

8022:pax7b
gene id: 8022:pax7b
uniprot id: H9NNC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

8022:LOC100136287
gene id: 8022:LOC100136287
uniprot id: Q1X7P4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8022:tlr3
gene id: 8022:tlr3
uniprot id: Q1PA38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8022:LOC100136703
gene id: 8022:LOC100136703
uniprot id: A3RID7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

8022:LOC100135807
gene id: 8022:LOC100135807
uniprot id: Q8QHL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

8022:LOC100135859
gene id: 8022:LOC100135859
uniprot id: Q9YGF2
names: Function
names: PTM
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity).
messages: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.

8022:stx7
gene id: 8022:stx7
uniprot id: C1BHQ8
names: Similarity
messages: Belongs to the syntaxin family.

8022:LOC100136320
gene id: 8022:LOC100136320
uniprot id: Q2I7F3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:rdh3
gene id: 8022:rdh3
uniprot id: C1BGU8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8022:nos2
gene id: 8022:nos2
uniprot id: Q8AXU2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

8022:ikzf1
gene id: 8022:ikzf1
uniprot id: O13089
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity).
messages: Expression begins at day 3-4 in the yolk sac and at day 5-6 in the embryo proper.
messages: Expression mainly limited to thymus, spleen and pronephros. Very low expression in liver. No expression in testis, brain, eye and muscle.
messages: Nucleus

8022:lipe1
gene id: 8022:lipe1
uniprot id: E2JFF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipid droplet
messages: caveola
messages: cytosol

8022:si:ch1073-280e3.1
gene id: 8022:si:ch1073-280e3.1
uniprot id: Q9DEC8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:sc61g
gene id: 8022:sc61g
uniprot id: C1BGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:irf2
gene id: 8022:irf2
uniprot id: Q8JH40
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8022:hhex
gene id: 8022:hhex
uniprot id: C1BGY3
names: Subcellular Location Annotation
messages: Nucleus

8022:sod1
gene id: 8022:sod1
uniprot id: Q8QHI0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

8022:pop5
gene id: 8022:pop5
uniprot id: C1BFT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

8022:sox9
gene id: 8022:sox9
uniprot id: Q9DE39
names: Subcellular Location Annotation
messages: Nucleus

8022:mstn2a
gene id: 8022:mstn2a
uniprot id: Q0R338
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

8022:zn706
gene id: 8022:zn706
uniprot id: C1BFE8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8022:adra1b
gene id: 8022:adra1b
uniprot id: Q3S2N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

8022:il21r
gene id: 8022:il21r
uniprot id: A1IMI0
names: Subcellular Location Annotation
messages: Membrane

8022:psb9
gene id: 8022:psb9
uniprot id: Q5FBU2
uniprot id: Q9PT27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

8022:LOC100136237
gene id: 8022:LOC100136237
uniprot id: Q1M197
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8022:ywhag2
gene id: 8022:ywhag2
uniprot id: Q6UFZ2
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Expressed from the 34 somite stage.
messages: Expressed in brain, gill, heart, intestine, kidney, liver, ovary, skeletal muscle, spleen and testis.
messages: Homodimer, and heterodimer with other family members.
messages: Repressed under stress conditions such as netting.

8022:LOC100499615
gene id: 8022:LOC100499615
uniprot id: D7REY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

8022:gp130
gene id: 8022:gp130
uniprot id: G7Z194
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

8022:sec22bb
gene id: 8022:sec22bb
uniprot id: C1BID8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

8022:si:dkey-88e18.2
gene id: 8022:si:dkey-88e18.2
uniprot id: Q5DVP7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-12B family.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

8022:vamp5
gene id: 8022:vamp5
uniprot id: C1BFP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

8022:ct030
gene id: 8022:ct030
uniprot id: C1BH90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

8022:LOC100136173
gene id: 8022:LOC100136173
uniprot id: Q6XQJ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8022:cox-2
gene id: 8022:cox-2
uniprot id: Q9W715
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

8022:arf1
gene id: 8022:arf1
uniprot id: C1BHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

8022:hsp90ab1
gene id: 8022:hsp90ab1
uniprot id: Q5DW66
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8022:tdt
gene id: 8022:tdt
uniprot id: Q92089
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Can also utilize other divalent cations, such as Mn(2+) and Co(2+) (in vitro).
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

8022:rhcg1-b
gene id: 8022:rhcg1-b
uniprot id: A8QJ81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cell membrane
messages: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.
messages: Membrane

8022:ube2c
gene id: 8022:ube2c
uniprot id: C1BER0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8022:pfdn1
gene id: 8022:pfdn1
uniprot id: C1BGH7
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

8022:LOC100499586
gene id: 8022:LOC100499586
uniprot id: C8BMC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

8022:LOC100136222
gene id: 8022:LOC100136222
uniprot id: Q56V27
names: Subcellular Location Annotation
messages: Membrane

8022:arpc5l
gene id: 8022:arpc5l
uniprot id: C1BHV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: cytoskeleton

8022:LOC100136292
gene id: 8022:LOC100136292
uniprot id: Q91216
names: Subcellular Location Annotation
messages: Nucleus

8022:plm
gene id: 8022:plm
uniprot id: C1BI48
names: Similarity
messages: Belongs to the FXYD family.

8022:LOC100301695
gene id: 8022:LOC100301695
uniprot id: C1BEN4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

8022:wnt4a2
gene id: 8022:wnt4a2
uniprot id: G9DAQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8022:cbpa1
gene id: 8022:cbpa1
uniprot id: C1BHH4
names: Similarity
messages: Belongs to the peptidase M14 family.

8022:cebpd
gene id: 8022:cebpd
uniprot id: A5X2W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

8022:becn1
gene id: 8022:becn1
uniprot id: Q4A1L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beclin family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Plays a central role in autophagy.
messages: autophagosome
messages: trans-Golgi network membrane

8022:tlr9
gene id: 8022:tlr9
uniprot id: B2MW43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8022:pfdn6
gene id: 8022:pfdn6
uniprot id: C1BEP1
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

8022:c8g
gene id: 8022:c8g
uniprot id: Q6H963
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8022:LOC100136181
gene id: 8022:LOC100136181
uniprot id: Q7SYF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

8022:gs04
gene id: 8022:gs04
uniprot id: Q8JI31
names: Similarity
messages: Belongs to the glutamine synthetase family.

8022:LOC100135817
gene id: 8022:LOC100135817
uniprot id: Q805B8
names: Function
names: Similarity
messages: Belongs to the calcitonin family.
messages: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

8022:vnp
gene id: 8022:vnp
uniprot id: Q7T2I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

8022:ssrb
gene id: 8022:ssrb
uniprot id: C1BG14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

8022:hmgb1a
gene id: 8022:hmgb1a
uniprot id: P07746
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Binds preferentially single-stranded DNA and unwinds double-stranded DNA.
messages: Chromosome
messages: Nucleus

8022:camk1b
gene id: 8022:camk1b
uniprot id: Q64HW3
names: Similarity
messages: Belongs to the protein kinase superfamily.

8022:casp3b
gene id: 8022:casp3b
uniprot id: E7BBR2
names: Similarity
messages: Belongs to the peptidase C14A family.

8022:LOC100136607
gene id: 8022:LOC100136607
uniprot id: Q9W6M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

8022:LOC100136247
gene id: 8022:LOC100136247
uniprot id: Q64HW6
names: Similarity
messages: Belongs to the CD36 family.

8022:pvalb1
gene id: 8022:pvalb1
uniprot id: E0WDA2
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

8022:LOC100305288
gene id: 8022:LOC100305288
uniprot id: C1BI39
names: Similarity
messages: Belongs to the SUI1 family.

8022:LOC100136107
gene id: 8022:LOC100136107
uniprot id: Q2PDF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

8022:LOC100135825
gene id: 8022:LOC100135825
uniprot id: Q762J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

8022:rgn
gene id: 8022:rgn
uniprot id: F2RM22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

8022:hspa8
gene id: 8022:hspa8
uniprot id: P08108
uniprot id: Q5DW63
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8022:LOC100379111
gene id: 8022:LOC100379111
uniprot id: A5X2V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

8022:LOC100136655
gene id: 8022:LOC100136655
uniprot id: Q6XQJ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8022:LOC100136271
gene id: 8022:LOC100136271
uniprot id: Q5UEM3
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

8022:traf2
gene id: 8022:traf2
uniprot id: Q7T2X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

8022:slc9a1b
gene id: 8022:slc9a1b
uniprot id: Q01345
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by cAMP, protein kinase A and protein kinase C.
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Inhibited by amiloride and 5-amino-substituted derivatives and activated in a cooperative fashion by intracellular H(+).
messages: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient.

8022:csn6
gene id: 8022:csn6
uniprot id: C1BFX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

8022:glut1a
gene id: 8022:glut1a
uniprot id: Q9I8M1
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

8022:c5h9orf78
gene id: 8022:c5h9orf78
uniprot id: C1BFP3
names: Similarity
messages: Belongs to the TLS1 family.

8022:dmrt1
gene id: 8022:dmrt1
uniprot id: Q9DG19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

8022:cd74b
gene id: 8022:cd74b
uniprot id: Q8JFN6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:cn112
gene id: 8022:cn112
uniprot id: C1BHU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane

8022:trmt112
gene id: 8022:trmt112
uniprot id: C1BHA2
names: Similarity
messages: Belongs to the TRM112 family.

8022:cyp1c1
gene id: 8022:cyp1c1
uniprot id: D3XFH7
names: Similarity
messages: Belongs to the cytochrome P450 family.

8022:hspa8b
gene id: 8022:hspa8b
uniprot id: C1BEL8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8022:spp2
gene id: 8022:spp2
uniprot id: A0A060YFX4
uniprot id: Q70I47
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Multiply phosphorylated at serine residues.
messages: Secreted

8022:si:dkey-42l23.2
gene id: 8022:si:dkey-42l23.2
uniprot id: C1BI79
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8022:rtn3
gene id: 8022:rtn3
uniprot id: Q6IEJ2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:zgc:92907
gene id: 8022:zgc:92907
uniprot id: C1BGJ4
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

8022:notch1
gene id: 8022:notch1
uniprot id: B5U9W5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

8022:chmp2a
gene id: 8022:chmp2a
uniprot id: C1BGQ5
names: Similarity
messages: Belongs to the SNF7 family.

8022:hsp70a
gene id: 8022:hsp70a
uniprot id: Q5KT35
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8022:ss18l2
gene id: 8022:ss18l2
uniprot id: C1BH49
names: Similarity
messages: Belongs to the SS18 family.

8022:cahz
gene id: 8022:cahz
uniprot id: Q7T2K6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8022:fabp3
gene id: 8022:fabp3
uniprot id: O13008
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
messages: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

8022:LOC100329197
gene id: 8022:LOC100329197
uniprot id: Q335X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

8022:grp94
gene id: 8022:grp94
uniprot id: D9UB75
names: Similarity
messages: Belongs to the heat shock protein 90 family.

8022:KEF44 p04
gene id: 8022:KEF44_p04
uniprot id: P11631
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion membrane

8022:nxt2
gene id: 8022:nxt2
uniprot id: C1BF84
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

8022:foxp3-1
gene id: 8022:foxp3-1
uniprot id: E4W7U4
names: Subcellular Location Annotation
messages: Nucleus

8022:gata3
gene id: 8022:gata3
uniprot id: E1UGZ1
names: Subcellular Location Annotation
messages: Nucleus

8022:rl26
gene id: 8022:rl26
uniprot id: C1BFB0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

8022:LOC100135941
gene id: 8022:LOC100135941
uniprot id: Q7SXA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

8022:idi1
gene id: 8022:idi1
uniprot id: C1BFN0
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

8022:ecac
gene id: 8022:ecac
uniprot id: Q7ZZQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8022:LOC100136296
gene id: 8022:LOC100136296
uniprot id: Q98973
names: Similarity
messages: Belongs to the globin family.

8022:hcn1
gene id: 8022:hcn1
uniprot id: Q71N53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

8022:rs15
gene id: 8022:rs15
uniprot id: C1BHW8
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

8022:nme7
gene id: 8022:nme7
uniprot id: C1BEX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

8022:rhcg
gene id: 8022:rhcg
uniprot id: Q4VUZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill (By similarity).
messages: Homotrimer.

8022:cj104
gene id: 8022:cj104
uniprot id: C1BF61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

8022:xip
gene id: 8022:xip
uniprot id: C1BF47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

8022:il10b
gene id: 8022:il10b
uniprot id: F8K872
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

8022:LOC100136198
gene id: 8022:LOC100136198
uniprot id: Q6UFZ3
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Expressed from late gastrula onwards.
messages: Expressed in brain, gill, heart, intestine, kidney, liver, ovary, skeletal muscle, spleen and testis.
messages: Homodimer, and heterodimer with other family members.
messages: Repressed under stress conditions such as netting.

8022:pigh
gene id: 8022:pigh
uniprot id: C1BF95
names: Similarity
messages: Belongs to the PIGH family.

8022:KEF44 p06
gene id: 8022:KEF44_p06
uniprot id: P11629
uniprot id: Q1L034
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

8022:apoa-i-1
gene id: 8022:apoa-i-1
uniprot id: O57523
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).
messages: Secreted

8022:spcs3
gene id: 8022:spcs3
uniprot id: C1BER9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane

8022:LOC100135856
gene id: 8022:LOC100135856
uniprot id: A0PAB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8022:mx2
gene id: 8022:mx2
uniprot id: Q91196
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By polyinosinic-polycytidylic acid (poly I:C) and viral haemorrhagic septicaemia virus (VHSV) strain 07.71 in muscle, head kidney, spleen and liver.
messages: Cytoplasm
messages: Does not inhibit strain RB-1 of the fish pathogen, infectious hematopoietic necrosis virus (IHNV).
messages: Nucleus

8022:LOC100136955
gene id: 8022:LOC100136955
uniprot id: Q91452
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
messages: Membrane

8022:mmp9
gene id: 8022:mmp9
uniprot id: Q8QFQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

8022:cxcr3.2
gene id: 8022:cxcr3.2
uniprot id: A4F341
uniprot id: A4F342
uniprot id: A4F343
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8022:LOC100136712
gene id: 8022:LOC100136712
uniprot id: A6ZIC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

8022:msra
gene id: 8022:msra
uniprot id: C1BFM0
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

8022:LOC100301670
gene id: 8022:LOC100301670
uniprot id: C0KTH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

8022:hbegf
gene id: 8022:hbegf
uniprot id: C1BHT9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:pdrg1
gene id: 8022:pdrg1
uniprot id: C1BGA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

8022:tmeda
gene id: 8022:tmeda
uniprot id: C1BG31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:kcnh2
gene id: 8022:kcnh2
uniprot id: A7LA95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
messages: Membrane

8022:nr3c1
gene id: 8022:nr3c1
uniprot id: Q6RKQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

8022:myod2
gene id: 8022:myod2
uniprot id: Q91206
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

8022:wnt4b
gene id: 8022:wnt4b
uniprot id: G9DAQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

8022:LOC100135967
gene id: 8022:LOC100135967
uniprot id: Q90ZQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

8022:stat5
gene id: 8022:stat5
uniprot id: Q9DG74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8022:foxl2l
gene id: 8022:foxl2l
uniprot id: Q6EAP0
names: Subcellular Location Annotation
messages: Nucleus

8022:il-8
gene id: 8022:il-8
uniprot id: Q98TQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

8022:LOC100136258
gene id: 8022:LOC100136258
uniprot id: Q1M159
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium

8022:rbhce2
gene id: 8022:rbhce2
uniprot id: D2YYG3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:LOC100136024
gene id: 8022:LOC100136024
uniprot id: A0A060WTK5
uniprot id: Q9YGD3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: All three isoforms are expressed in gill, kidney, liver and spleen. Isoform 1 is also expressed in blood. None of the isoforms are expressed in brain.
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

8022:krt5
gene id: 8022:krt5
uniprot id: Q90W75
names: Similarity
messages: Belongs to the intermediate filament family.

8022:nola3
gene id: 8022:nola3
uniprot id: C1BGB0
names: Similarity
messages: Belongs to the NOP10 family.

8022:LOC100135798
gene id: 8022:LOC100135798
uniprot id: Q9PT09
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus

8022:apoc2
gene id: 8022:apoc2
uniprot id: Q9DG75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C2 family.
messages: Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.
messages: Secreted

8022:nedd8
gene id: 8022:nedd8
uniprot id: C1BFL8
names: Similarity
messages: Belongs to the ubiquitin family.

8022:hsp47
gene id: 8022:hsp47
uniprot id: Q5DW60
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

8022:LOC100136046
gene id: 8022:LOC100136046
uniprot id: Q711N8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

8022:LOC100136293
gene id: 8022:LOC100136293
uniprot id: P79821
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8022:polr2i
gene id: 8022:polr2i
uniprot id: C1BGM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

8022:st3gal-i
gene id: 8022:st3gal-i
uniprot id: Q70D59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8022:cck-t
gene id: 8022:cck-t
uniprot id: Q9YGE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

8022:LOC100136266
gene id: 8022:LOC100136266
uniprot id: Q64FL4
names: Subcellular Location Annotation
messages: Membrane

8022:LOC100136663
gene id: 8022:LOC100136663
uniprot id: Q64HX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

8022:ckba
gene id: 8022:ckba
uniprot id: P24722
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Exists in many tissues, but preferentially in testis.
messages: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

8022:sumo2
gene id: 8022:sumo2
uniprot id: C1BGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

8022:ifn1
gene id: 8022:ifn1
uniprot id: Q5U778
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

8022:LOC100136193
gene id: 8022:LOC100136193
uniprot id: Q6UFZ8
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Expressed in brain, gill, heart, intestine, kidney, liver, ovary, skeletal muscle, spleen and testis.
messages: Expressed throughout development.
messages: Homodimer, and heterodimer with other family members.
messages: Repressed under stress conditions such as netting.

8022:gtf2a2
gene id: 8022:gtf2a2
uniprot id: C1BFG8
uniprot id: Q90YG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).
messages: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha, a beta and a gamma subunit. Interacts with NCOA6 general coactivator. TFIIA forms a complex with TBP (By similarity).

8022:LOC100170204
gene id: 8022:LOC100170204
uniprot id: Q8QGB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8022:fam32a
gene id: 8022:fam32a
uniprot id: C1BGR5
names: Similarity
messages: Belongs to the FAM32 family.

8022:litaf
gene id: 8022:litaf
uniprot id: C1BHA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

8022:gbg5
gene id: 8022:gbg5
uniprot id: C1BGH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8022:mul1b
gene id: 8022:mul1b
uniprot id: I1W5K1
names: Subcellular Location Annotation
messages: Membrane

8022:wt1b
gene id: 8022:wt1b
uniprot id: Q90XX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

8022:LOC100135902
gene id: 8022:LOC100135902
uniprot id: Q9I8S9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

8022:LOC100135826
gene id: 8022:LOC100135826
uniprot id: Q68YC2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

8022:LOC100136214
gene id: 8022:LOC100136214
uniprot id: Q6EAN9
names: Subcellular Location Annotation
messages: Nucleus

8022:LOC100135834
gene id: 8022:LOC100135834
uniprot id: Q5TM02
names: Subcellular Location Annotation
messages: Nucleus

8022:tnr5
gene id: 8022:tnr5
uniprot id: C1BI10
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:tradd
gene id: 8022:tradd
uniprot id: A0A060W3P9
uniprot id: Q1M161
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
messages: Cytoplasm
messages: Heterodimer with tnfrsf1a.
messages: Nucleus
messages: Requires the intact death domain to associate with tnfrsf1a.
messages: cytoskeleton

8022:ei2ba
gene id: 8022:ei2ba
uniprot id: C1BGT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

8022:tfa
gene id: 8022:tfa
uniprot id: Q9PT13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.

8022:hsp70b
gene id: 8022:hsp70b
uniprot id: Q5KT34
names: Similarity
messages: Belongs to the heat shock protein 70 family.

8022:il-1r1
gene id: 8022:il-1r1
uniprot id: Q8AXU1
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

8022:cyp11b
gene id: 8022:cyp11b
uniprot id: Q9PT16
names: Similarity
messages: Belongs to the cytochrome P450 family.

8022:selenof
gene id: 8022:selenof
uniprot id: Q6X4M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the selenoprotein M/F family.
messages: Endoplasmic reticulum lumen
messages: Expressed in the brain, liver and retina. Localized to the retinal ganglion cell layer, the inner nuclear layer and the outer nuclear layer at both parr and smolt stages.
messages: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity). May be involved in retinal development.

8022:piwil2
gene id: 8022:piwil2
uniprot id: A6P7L8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Piwi subfamily.
messages: Component of the PET complex.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' piwil4. Piwil2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded. Required for piwil4/miwi2 nuclear localization and association with secondary piRNAs antisense.
messages: Methylated on arginine residues; required for the interaction with Tudor domain-containing protein and subsequent localization to the meiotic nuage, also named P granule.
messages: Nucleus

8022:imp3
gene id: 8022:imp3
uniprot id: C1BGU9
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

8022:LOC100136291
gene id: 8022:LOC100136291
uniprot id: P02141
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from gills to the various peripheral tissues.
messages: Red blood cells.

8022:drd2a
gene id: 8022:drd2a
uniprot id: Q90WQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8022:LOC100136249
gene id: 8022:LOC100136249
uniprot id: Q1M177
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

8022:LOC100136950
gene id: 8022:LOC100136950
uniprot id: Q76KE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8022:sox11b
gene id: 8022:sox11b
uniprot id: O57399
names: Subcellular Location Annotation
messages: Nucleus

8022:bola3
gene id: 8022:bola3
uniprot id: C1BFU2
names: Similarity
messages: Belongs to the BolA/IbaG family.

8022:rl36a
gene id: 8022:rl36a
uniprot id: C1BGZ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

8022:anp
gene id: 8022:anp
uniprot id: Q7T2I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

8022:igf2b
gene id: 8022:igf2b
uniprot id: C6GBY8
uniprot id: Q02816
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.

8022:LOC100136309
gene id: 8022:LOC100136309
uniprot id: Q0H7E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-beta.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

8022:gbg2
gene id: 8022:gbg2
uniprot id: C1BH40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

8022:saa
gene id: 8022:saa
uniprot id: A6PZ09
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

8022:dynlt1
gene id: 8022:dynlt1
uniprot id: C1BF42
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

8022:tnfsf13b
gene id: 8022:tnfsf13b
uniprot id: Q2I7F7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:car8
gene id: 8022:car8
uniprot id: Q5I2J1
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

8022:serpinf2b
gene id: 8022:serpinf2b
uniprot id: F8LFR3
names: Similarity
messages: Belongs to the serpin family.

8022:LOC100136251
gene id: 8022:LOC100136251
uniprot id: Q64HW4
names: Similarity
messages: Belongs to the serpin family.

8022:cx43
gene id: 8022:cx43
uniprot id: Q3HNW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

8022:fbxo32
gene id: 8022:fbxo32
uniprot id: D9IV46
names: Subcellular Location Annotation
messages: Nucleus

8022:rbp4
gene id: 8022:rbp4
uniprot id: Q90Y51
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

8022:rs21
gene id: 8022:rs21
uniprot id: C1BGB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

8022:nifk
gene id: 8022:nifk
uniprot id: C1BG54
names: Subcellular Location Annotation
messages: nucleolus

8022:sec20
gene id: 8022:sec20
uniprot id: C1BI84
names: Subcellular Location Annotation
messages: Membrane

8022:LOC100136280
gene id: 8022:LOC100136280
uniprot id: Q5FXK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Nucleus
messages: Secreted

8022:cklf7
gene id: 8022:cklf7
uniprot id: C1BIE2
names: Subcellular Location Annotation
messages: Membrane

8022:lpl
gene id: 8022:lpl
uniprot id: Q9W6Y2
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

8022:chmp5b
gene id: 8022:chmp5b
uniprot id: C1BHT1
names: Similarity
messages: Belongs to the SNF7 family.

8022:ftz-f1
gene id: 8022:ftz-f1
uniprot id: Q5EIB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

8022:antiprot1
gene id: 8022:antiprot1
uniprot id: Q7ZZW1
names: Similarity
messages: Belongs to the serpin family.

8022:ifih1
gene id: 8022:ifih1
uniprot id: D7F7W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

8022:LOC100136122
gene id: 8022:LOC100136122
uniprot id: Q4LBC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tollip family.
messages: Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.
messages: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
messages: Cytoplasm
messages: Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain).
messages: Ubiquitous.

8022:LOC100135906
gene id: 8022:LOC100135906
uniprot id: Q9I9M8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:prf1
gene id: 8022:prf1
uniprot id: Q0VJ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

8022:cetn4
gene id: 8022:cetn4
uniprot id: C1BFN9
names: Similarity
messages: Belongs to the centrin family.

8022:LOC100136246
gene id: 8022:LOC100136246
uniprot id: Q1M179
names: Similarity
messages: Belongs to the AAA ATPase family.

8022:gcg1
gene id: 8022:gcg1
uniprot id: Q91971
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
messages: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
messages: Secreted

8022:LOC100136696
gene id: 8022:LOC100136696
uniprot id: A0SZ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

8022:ga45b
gene id: 8022:ga45b
uniprot id: C1BER7
names: Similarity
messages: Belongs to the GADD45 family.

8022:igfbp1a
gene id: 8022:igfbp1a
uniprot id: G3GJ68
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds equally well IGF1 and IGF2.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:pgpi
gene id: 8022:pgpi
uniprot id: C1BG35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

8022:KEF44 p11
gene id: 8022:KEF44_p11
uniprot id: E2JDJ7
uniprot id: P48170
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

8022:mc1r
gene id: 8022:mc1r
uniprot id: D6CIN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

8022:LOC100135946
gene id: 8022:LOC100135946
uniprot id: P43648
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.
messages: Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.
messages: Produced and secreted by the corpuscles of Stannius.
messages: Secreted

8022:taf12
gene id: 8022:taf12
uniprot id: C1BFS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

8022:sparc
gene id: 8022:sparc
uniprot id: Q9YGD9
names: Similarity
messages: Belongs to the SPARC family.

8022:eif5a
gene id: 8022:eif5a
uniprot id: C1BG36
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

8022:pfn1
gene id: 8022:pfn1
uniprot id: C1BHQ1
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

8022:ssr3
gene id: 8022:ssr3
uniprot id: C1BF31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

8022:LOC100135786
gene id: 8022:LOC100135786
uniprot id: O57397
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

8022:ccl4
gene id: 8022:ccl4
uniprot id: Q64IC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

8022:pigp
gene id: 8022:pigp
uniprot id: C1BGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

8022:asip1
gene id: 8022:asip1
uniprot id: D6CIN2
names: Subcellular Location Annotation
messages: Secreted

8022:vegf
gene id: 8022:vegf
uniprot id: Q6H8S7
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

8022:rl28
gene id: 8022:rl28
uniprot id: C1BFH9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

8022:s8
gene id: 8022:s8
uniprot id: Q90W73
names: Similarity
messages: Belongs to the intermediate filament family.

8022:ngb
gene id: 8022:ngb
uniprot id: P59743
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the globin family.
messages: Cytoplasm
messages: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Capable of penetrating cell membranes (By similarity).
messages: Monomer.
messages: Perikaryon

8022:LOC100136702
gene id: 8022:LOC100136702
uniprot id: A3RID6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

8022:LOC100135961
gene id: 8022:LOC100135961
uniprot id: A0A060XW28
uniprot id: Q98SN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
messages: Membrane

8022:leap2
gene id: 8022:leap2
uniprot id: Q64KQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

8022:LOC100136195
gene id: 8022:LOC100136195
uniprot id: Q6UFZ6
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

8022:tppc3
gene id: 8022:tppc3
uniprot id: C1BH07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

8022:nppb
gene id: 8022:nppb
uniprot id: Q4AEE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

8022:LOC100135879
gene id: 8022:LOC100135879
uniprot id: Q9YGD6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

8022:casp6
gene id: 8022:casp6
uniprot id: C1BI95
names: Similarity
messages: Belongs to the peptidase C14A family.

8022:chi
gene id: 8022:chi
uniprot id: Q5NKG0
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

8022:snrpd3l
gene id: 8022:snrpd3l
uniprot id: C1BFR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

8022:c4b
gene id: 8022:c4b
uniprot id: Q70TF5
names: Subcellular Location Annotation
messages: Secreted

8022:pb1
gene id: 8022:pb1
uniprot id: C1BFT5
names: Subcellular Location Annotation
messages: Nucleus

8022:eif3h
gene id: 8022:eif3h
uniprot id: C1BGV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

8022:balm
gene id: 8022:balm
uniprot id: Q2I7F5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:ube2b
gene id: 8022:ube2b
uniprot id: C1BEI3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

8022:apoe
gene id: 8022:apoe
uniprot id: Q9PT02
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

8022:otulina
gene id: 8022:otulina
uniprot id: C1BF67
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

8022:il4r2
gene id: 8022:il4r2
uniprot id: E6ZCC7
names: Subcellular Location Annotation
messages: Membrane

8022:arnt
gene id: 8022:arnt
uniprot id: P79832
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA-binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR).
messages: Expressed at much lower levels than isoform 1.
messages: Has reduced affinity for the XRE and functions negatively in AHR-mediated signaling by disrupting the binding of dimers formed by isoform 1 and AHR to the XRE.
messages: In day 23 embryos, expressed at highest levels in brain, spinal cord and epithelial cells of developing gill. Expressed at higher levels throughout all tissues in day 27 and 35 sac fry, predominantly in brain and spinal cord. In the adult, isoform 1 is widely expressed (at protein level) and is detected in liver, gill, gonad, brain, kidney, heart, spleen and muscle. Isoform 2 is expressed (at protein level) only in gills with highest expression in the epithelial cells sourrounding the gill lamellae.
messages: Isoform 1 is expressed both in juvenile and adult with highest levels in day 42 sac fry. Isoform 2 is only expressed in adult (at protein level).
messages: Nucleus
messages: Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:11230806, PubMed:8940073). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity).
messages: The C-terminal region of isoform 1 contains a transactivation domain. The Pro/Ser/Thr-rich region in the C-terminus of isoform 2 inhibits DNA-binding of ARNT-AHR dimers.

8022:LOC101268960
gene id: 8022:LOC101268960
uniprot id: L7UKG5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8022:pad
gene id: 8022:pad
uniprot id: B9WPX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

8022:chrna9
gene id: 8022:chrna9
uniprot id: Q68RJ7
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Expressed in the brain, liver, olfactory mucosa, pituitary gland and hair cells of the saccule.
messages: Postsynaptic cell membrane

8022:masp1
gene id: 8022:masp1
uniprot id: B5KWB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:cox-1
gene id: 8022:cox-1
uniprot id: Q9DEQ0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:gdh03
gene id: 8022:gdh03
uniprot id: Q8JHX9
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

8022:cxcl12b
gene id: 8022:cxcl12b
uniprot id: H1ZZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

8022:wdr82
gene id: 8022:wdr82
uniprot id: C1BIG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

8022:rfa3
gene id: 8022:rfa3
uniprot id: C1BGW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

8022:LOC100653464
gene id: 8022:LOC100653464
uniprot id: F1DRC4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:rtgdnf
gene id: 8022:rtgdnf
uniprot id: M1VK54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

8022:lyrm1
gene id: 8022:lyrm1
uniprot id: C1BIA4
names: Similarity
messages: Belongs to the complex I LYR family.

8022:LOC100301658
gene id: 8022:LOC100301658
uniprot id: B8YI11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

8022:gfra1a
gene id: 8022:gfra1a
uniprot id: M1UZC9
names: Similarity
messages: Belongs to the GDNFR family.

8022:cf191
gene id: 8022:cf191
uniprot id: C1BG33
names: Subcellular Location Annotation
messages: Membrane

8022:eomesb
gene id: 8022:eomesb
uniprot id: J9PYB5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8022:irf-10
gene id: 8022:irf-10
uniprot id: D8FRP0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8022:LOC100305272
gene id: 8022:LOC100305272
uniprot id: C1BHX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

8022:cyp1c3
gene id: 8022:cyp1c3
uniprot id: D3XFH8
names: Similarity
messages: Belongs to the cytochrome P450 family.

8022:tf
gene id: 8022:tf
uniprot id: Q90W13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

8022:ndus5
gene id: 8022:ndus5
uniprot id: C1BH75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

8022:s10i
gene id: 8022:s10i
uniprot id: C1BHS7
names: Similarity
messages: Belongs to the S-100 family.

8022:ucn
gene id: 8022:ucn
uniprot id: O93448
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted
messages: Urotensin is found in the teleost caudal neurosecretory system. It has a suggested role in osmoregulation and as a corticotropin-releasing factor. The non-hormonal portion of this precursor may be a urotensin binding protein, urophysin.

8022:LOC100136288
gene id: 8022:LOC100136288
uniprot id: Q1X7P3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

8022:frih
gene id: 8022:frih
uniprot id: C1BEL9
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

8022:leg1
gene id: 8022:leg1
uniprot id: Q5QT17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: May be involved in early liver development.
messages: Secreted

8022:rtor1
gene id: 8022:rtor1
uniprot id: Q1XG38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8022:opi-1
gene id: 8022:opi-1
uniprot id: Q8AWW6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:dck
gene id: 8022:dck
uniprot id: C1BHG5
names: Similarity
messages: Belongs to the DCK/DGK family.

8022:prdx1
gene id: 8022:prdx1
uniprot id: Q9I886
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

8022:LOC100135862
gene id: 8022:LOC100135862
uniprot id: O42241
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins.

8022:tlr22
gene id: 8022:tlr22
uniprot id: Q6KCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8022:rcl1
gene id: 8022:rcl1
uniprot id: C1BFN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

8022:cfh
gene id: 8022:cfh
uniprot id: Q2L4Q6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:you2
gene id: 8022:you2
uniprot id: C1BFV7
names: Similarity
messages: Belongs to the FAM136 family.

8022:psb8
gene id: 8022:psb8
uniprot id: C1BID7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

8022:bpnt1
gene id: 8022:bpnt1
uniprot id: C1BFL2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8022:rblce
gene id: 8022:rblce
uniprot id: D2YYG4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:arl2
gene id: 8022:arl2
uniprot id: C1BIF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

8022:nfip1
gene id: 8022:nfip1
uniprot id: C1BEY0
names: Subcellular Location Annotation
messages: Membrane

8022:LOC100136769
gene id: 8022:LOC100136769
uniprot id: P32847
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A dimer in solution, it spans the membrane asymmetrically and appears to be tetrameric.
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.

8022:LOC100136140
gene id: 8022:LOC100136140
uniprot id: Q0E757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

8022:ghs-r
gene id: 8022:ghs-r
uniprot id: A8CGH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

8022:tgfr2
gene id: 8022:tgfr2
uniprot id: I2FKQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

8022:vatf
gene id: 8022:vatf
uniprot id: C1BEU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

8022:ccr9a
gene id: 8022:ccr9a
uniprot id: O42444
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

8022:stt3a
gene id: 8022:stt3a
uniprot id: C1BGI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

8022:iip2
gene id: 8022:iip2
uniprot id: Q8QFL3
names: Similarity
messages: Belongs to the CD225/Dispanin family.

8022:c3ar1
gene id: 8022:c3ar1
uniprot id: Q2WED0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks an insertion found in the C3ar family. It remains uncertain whether it belongs to the C3ar or the C5ar family.
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production (By similarity).

8022:rpl37a
gene id: 8022:rpl37a
uniprot id: C1BH43
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

8022:LOC100135793
gene id: 8022:LOC100135793
uniprot id: Q9W635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

8022:bl1s3
gene id: 8022:bl1s3
uniprot id: C1BFC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S3 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
messages: Cytoplasm

8022:dgcr6
gene id: 8022:dgcr6
uniprot id: C1BEX0
names: Similarity
messages: Belongs to the gonadal family.

8022:arpin
gene id: 8022:arpin
uniprot id: C1BHE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arpin family.
messages: lamellipodium

8022:prl
gene id: 8022:prl
uniprot id: A0A060WYA2
uniprot id: P21993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

8022:LOC100135972
gene id: 8022:LOC100135972
uniprot id: Q90ZP4
names: Subcellular Location Annotation
messages: Membrane

8022:crf
gene id: 8022:crf
uniprot id: Q6YDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

8022:suclg1
gene id: 8022:suclg1
uniprot id: C0KIP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

8022:il2rb2
gene id: 8022:il2rb2
uniprot id: G4RJE1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

8022:LOC100136185
gene id: 8022:LOC100136185
uniprot id: Q6VYM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8022:rrmj2
gene id: 8022:rrmj2
uniprot id: C1BI54
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

8022:coq7
gene id: 8022:coq7
uniprot id: C1BG71
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

8022:sptssa
gene id: 8022:sptssa
uniprot id: C1BHM8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:LOC100136790
gene id: 8022:LOC100136790
uniprot id: B0L0M1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

8022:cpt1ab
gene id: 8022:cpt1ab
uniprot id: D9Z8Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

8022:alox5ap
gene id: 8022:alox5ap
uniprot id: C1BIG0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

8022:oclna
gene id: 8022:oclna
uniprot id: D7NZJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

8022:fd6d
gene id: 8022:fd6d
uniprot id: Q98SW7
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

8022:ctsbb
gene id: 8022:ctsbb
uniprot id: Q90WC3
names: Similarity
messages: Belongs to the peptidase C1 family.

8022:c5ar
gene id: 8022:c5ar
uniprot id: A0A060YND6
uniprot id: Q6UNA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High expression in head, kidney and posterior kidney, lower levels in peripheral blood leukocytes and spleen, low expression in brain and gills, heart, intestine and very low expression in liver and muscle.
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

8022:LOC101268922
gene id: 8022:LOC101268922
uniprot id: G9B9Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

8022:LOC100136303
gene id: 8022:LOC100136303
uniprot id: Q2LK91
names: Function
names: Similarity
names: Subunit
messages: Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
messages: Belongs to the fucolectin family.
messages: Homotrimer.

8022:LOC100136711
gene id: 8022:LOC100136711
uniprot id: A9LHI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cell membrane
messages: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.
messages: Membrane

8022:c7a
gene id: 8022:c7a
uniprot id: Q6H965
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:bc10
gene id: 8022:bc10
uniprot id: C1BEP0
names: Similarity
messages: Belongs to the BLCAP family.

8022:ciao2b
gene id: 8022:ciao2b
uniprot id: C1BHI3
names: Similarity
messages: Belongs to the MIP18 family.

8022:bambia
gene id: 8022:bambia
uniprot id: B7SFF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

8022:rag1
gene id: 8022:rag1
uniprot id: Q91187
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAG1 family.
messages: Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).
messages: Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination (By similarity).
messages: Homodimer. Component of the RAG complex composed of core components rag1 and rag2 (By similarity).
messages: Nucleus
messages: The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.
messages: The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity.

8022:atpbb
gene id: 8022:atpbb
uniprot id: C1BHQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

8022:cd3z
gene id: 8022:cd3z
uniprot id: C1BH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

8022:LOC100136252
gene id: 8022:LOC100136252
uniprot id: Q1M175
names: Subcellular Location Annotation
messages: dendrite

8022:lhcgr
gene id: 8022:lhcgr
uniprot id: Q71MM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

8022:gnrh-r
gene id: 8022:gnrh-r
uniprot id: Q9I986
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8022:LOC100136304
gene id: 8022:LOC100136304
uniprot id: Q3I346
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

8022:tlr5m
gene id: 8022:tlr5m
uniprot id: Q68CI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

8022:foxp3-2
gene id: 8022:foxp3-2
uniprot id: E4W7U5
names: Subcellular Location Annotation
messages: Nucleus

8022:LOC100135920
gene id: 8022:LOC100135920
uniprot id: Q90ZD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

8022:ndkb
gene id: 8022:ndkb
uniprot id: C1BIF8
names: Similarity
messages: Belongs to the NDK family.

8022:LOC100136136
gene id: 8022:LOC100136136
uniprot id: Q2YHL9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

8022:esr2a
gene id: 8022:esr2a
uniprot id: Q0H7E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

8022:LOC100135998
gene id: 8022:LOC100135998
uniprot id: Q8QGB2
names: Subcellular Location Annotation
messages: Membrane

8022:if6
gene id: 8022:if6
uniprot id: C1BFB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: nucleolus

8022:LOC100305243
gene id: 8022:LOC100305243
uniprot id: C1BHL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

8022:LOC100170202
gene id: 8022:LOC100170202
uniprot id: A0A060WE89
uniprot id: P26351
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

8022:LOC100335039
gene id: 8022:LOC100335039
uniprot id: A0A060XA34
uniprot id: P51467
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arrestin family.
messages: Cytoplasm

8022:tk1
gene id: 8022:tk1
uniprot id: C0KIP5
names: Similarity
messages: Belongs to the thymidine kinase family.

8022:LOC100136786
gene id: 8022:LOC100136786
uniprot id: P49843
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The ligand-binding domain is required for correct chromosome segregation during mitosis although ligand binding is not required.
messages: Cytoplasm
messages: Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity).
messages: Isoform 1 is expressed in all tissues tested including liver, gills, intestine, skeletal muscle, kidney, heart, spleen, stomach, brain, pituitary, ovary, testis, skin and bladder. Isoform 2 is found only in testis.
messages: Mitochondrion
messages: Nucleus
messages: Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids. May be dephosphorylated by PPP5C, attenuates NR3C1 action (By similarity).
messages: Receptor for glucocorticoids (GC) (PubMed:7649084, PubMed:8766708). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (By similarity). Affects inflammatory responses, cellular proliferation and differentiation in target tissues (By similarity). Involved in chromatin remodeling (By similarity). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). Mediates glucocorticoid-induced apoptosis (By similarity). Promotes accurate chromosome segregation during mitosis (By similarity). May act as a tumor suppressor (By similarity). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity).
messages: centrosome
messages: spindle

8022:btg3
gene id: 8022:btg3
uniprot id: C1BGU5
names: Similarity
messages: Belongs to the BTG family.

8022:zgc:86839
gene id: 8022:zgc:86839
uniprot id: C1BGK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

8022:pou1f1
gene id: 8022:pou1f1
uniprot id: Q08478
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.

8022:rs25
gene id: 8022:rs25
uniprot id: C1BI45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

8022:stat1-1
gene id: 8022:stat1-1
uniprot id: O13131
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

8022:defb4
gene id: 8022:defb4
uniprot id: C9WX71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

8022:LOC101268961
gene id: 8022:LOC101268961
uniprot id: L7Z8X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

8022:tbca
gene id: 8022:tbca
uniprot id: C1BFK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

8022:atp1a2a
gene id: 8022:atp1a2a
uniprot id: Q6VYM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

8022:ucp2a
gene id: 8022:ucp2a
uniprot id: Q2PXW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

8022:gh2
gene id: 8022:gh2
uniprot id: P20332
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.
messages: Secreted

8022:impa1
gene id: 8022:impa1
uniprot id: C1BF75
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

8022:ddx4
gene id: 8022:ddx4
uniprot id: Q9PT10
names: Similarity
messages: Belongs to the DEAD box helicase family.

8022:nhe3
gene id: 8022:nhe3
uniprot id: A4GWV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

8022:LOC100305219
gene id: 8022:LOC100305219
uniprot id: C1BHB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

8022:KEF44 p07
gene id: 8022:KEF44_p07
uniprot id: P48172
uniprot id: Q1L035
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

8022:eomesa
gene id: 8022:eomesa
uniprot id: J9PYF5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

8022:nfu1
gene id: 8022:nfu1
uniprot id: C1BGC1
names: Similarity
messages: Belongs to the NifU family.

8022:polr2j
gene id: 8022:polr2j
uniprot id: C1BF62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

8022:om-ii
gene id: 8022:om-ii
uniprot id: A0A060YJ16
uniprot id: P28771
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ependymin family.
messages: Binds calcium through the terminal sialic acids.
messages: EPDs are synthesized in the meninx and secreted in the cerebrospinal fluid.
messages: May play a role in neural plasticity. May be involved during axon regeneration.
messages: Secreted

8022:tpk1
gene id: 8022:tpk1
uniprot id: I3PU26
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

8022:lipea
gene id: 8022:lipea
uniprot id: E2JFF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipid droplet
messages: caveola
messages: cytosol

8022:rs14
gene id: 8022:rs14
uniprot id: C1BGI0
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

8022:stom
gene id: 8022:stom
uniprot id: A6BLJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8022:LOC110521832
gene id: 8022:LOC110521832
uniprot id: A3EZK8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

8022:ifngamma2
gene id: 8022:ifngamma2
uniprot id: B6UQB7
names: Similarity
messages: Belongs to the type II (or gamma) interferon family.

8022:polr2d
gene id: 8022:polr2d
uniprot id: C1BFY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

8022:st8sia2
gene id: 8022:st8sia2
uniprot id: A0PAB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

8022:LOC100136691
gene id: 8022:LOC100136691
uniprot id: Q09IZ1
names: Similarity
messages: Belongs to the cyclin family.

bpi-1
gene id: 8022:lbp/bpi-1
uniprot id: Q8JFX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

8022:kitlg
gene id: 8022:kitlg
uniprot id: H1ZRI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Secreted
messages: filopodium
messages: lamellipodium

8022:gapdh
gene id: 8022:gapdh
uniprot id: Q90ZF1
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

8022:LOC100136184
gene id: 8022:LOC100136184
uniprot id: Q6VYM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

8022:impact
gene id: 8022:impact
uniprot id: C1BER4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

8022:lect2
gene id: 8022:lect2
uniprot id: Q8JJ67
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

8022:nduad
gene id: 8022:nduad
uniprot id: C1BF24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

8022:zgc:163057
gene id: 8022:zgc:163057
uniprot id: C1BEM8
names: Similarity
messages: Belongs to the globin family.

8022:LOC100136335
gene id: 8022:LOC100136335
uniprot id: A0A060YTK5
uniprot id: Q20A00
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DDIT4 family.
messages: Cytoplasm
messages: Induced by LPS and zymosan in macrophages.
messages: Inhibits cell growth by regulating the TOR signaling pathway upstream of the tsc1-tsc2 complex and downstream of akt1.

8022:csf-3
gene id: 8022:csf-3
uniprot id: D4YWD9
names: Similarity
messages: Belongs to the IL-6 superfamily.

8022:LOC100136597
gene id: 8022:LOC100136597
uniprot id: Q800K1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

8022:m1ip1
gene id: 8022:m1ip1
uniprot id: C1BGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

8022:fbxo25
gene id: 8022:fbxo25
uniprot id: D9IV45
names: Subcellular Location Annotation
messages: Nucleus

8022:adra1a
gene id: 8022:adra1a
uniprot id: Q2VA56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

8022:nkx2.1c
gene id: 8022:nkx2.1c
uniprot id: Q58A09
names: Subcellular Location Annotation
messages: Nucleus

8022:ift122
gene id: 8022:ift122
uniprot id: C1BH47
names: Subcellular Location Annotation
messages: cilium

8022:lamp3
gene id: 8022:lamp3
uniprot id: I4EBR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

8022:praf3
gene id: 8022:praf3
uniprot id: C1BHH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

8022:dazl
gene id: 8022:dazl
uniprot id: E9NQD4
names: Subcellular Location Annotation
messages: Cytoplasm

8022:mrap
gene id: 8022:mrap
uniprot id: F4NAR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

8022:abt1
gene id: 8022:abt1
uniprot id: C1BHD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

8022:LOC101268957
gene id: 8022:LOC101268957
uniprot id: K7NAJ3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Heterodimer with IFNAR2; forming the receptor for type I interferon.
messages: In the fibroblastic RTG-2 cell line, induced by polyinosine-polycytidylic acid (poly(I:C)), a synthetic analog of dsRNA, that binds TLR3.
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:24244163). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (By similarity). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (By similarity). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (By similarity). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity).
messages: perinuclear region

8022:KEF44 p12
gene id: 8022:KEF44_p12
uniprot id: P48175
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion inner membrane

8022:light
gene id: 8022:light
uniprot id: Q2I7F4
names: Similarity
messages: Belongs to the tumor necrosis factor family.

8022:hspb1
gene id: 8022:hspb1
uniprot id: Q4F877
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: spindle

8022:lyz2
gene id: 8022:lyz2
uniprot id: P11941
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has antibacterial activity against the Gram positive bacterium P.citreus. Has no antibacterial activity against the Gram negative bacteria E.coli and Y.ruckeri. Does not have hemolytic activity against trout erythrocytes.
messages: Secreted

8022:LOC100305210
gene id: 8022:LOC100305210
uniprot id: C1BH68
names: Subcellular Location Annotation
messages: Secreted

8022:nkx2.4a
gene id: 8022:nkx2.4a
uniprot id: Q58A07
names: Subcellular Location Annotation
messages: Nucleus