7955:fam49a
gene id: 7955:fam49a
uniprot id: A0A0R4IMR9
uniprot id: A0A8M1P8U3
uniprot id: A0A8M2B7R9
uniprot id: Q5TZ57
uniprot id: Q7ZW35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

7955:ipo7
gene id: 7955:ipo7
uniprot id: Q6NYN3
names: Subcellular Location Annotation
messages: Cytoplasm

7955:wnt10a
gene id: 7955:wnt10a
uniprot id: A0A8N1Z0N8
uniprot id: B0V1G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:rer1
gene id: 7955:rer1
uniprot id: A0A8M2BER0
uniprot id: Q6PE45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

7955:si:dkey-224e22.2
gene id: 7955:si:dkey-224e22.2
uniprot id: A0A8M3AJT8
uniprot id: A0A8M3AS61
uniprot id: A2BIK1
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

7955:si:ch73-359m17.2
gene id: 7955:si:ch73-359m17.2
uniprot id: A0A8M2BHH5
uniprot id: Q2LK84
names: Function
names: Similarity
names: Subunit
messages: Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
messages: Belongs to the fucolectin family.
messages: Homotrimer.

7955:cds2
gene id: 7955:cds2
uniprot id: Q7SXP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

7955:zgc:136864
gene id: 7955:zgc:136864
uniprot id: Q24JV4
names: Similarity
messages: Belongs to the UPF0390 family.

7955:lpgat1
gene id: 7955:lpgat1
uniprot id: Q4KMD5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

7955:uqcrfs1
gene id: 7955:uqcrfs1
uniprot id: A7MCR1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

7955:tmem245
gene id: 7955:tmem245
uniprot id: A0A8M1PSG2
uniprot id: A0A8M3B1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

7955:cops2
gene id: 7955:cops2
uniprot id: A0A8M2BAA6
uniprot id: A0A8M9PUW2
uniprot id: Q6IQT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN2 family.
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
messages: Nucleus

7955:med19b
gene id: 7955:med19b
uniprot id: B2GRD6
uniprot id: Q6DRL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7955:gata2b
gene id: 7955:gata2b
uniprot id: A0A8M3ATI9
uniprot id: F1QD30
uniprot id: Q6DG89
names: Subcellular Location Annotation
messages: Nucleus

7955:orc4
gene id: 7955:orc4
uniprot id: A0A8M9QFA6
uniprot id: F1QRE0
uniprot id: Q6NWF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

7955:apoea
gene id: 7955:apoea
uniprot id: Q503V2
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

7955:plxnb1a
gene id: 7955:plxnb1a
uniprot id: A0A8M1QKJ0
uniprot id: A0A8M3AMN7
uniprot id: A0A8M3B5Y3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:dlg5b.1
gene id: 7955:dlg5b.1
uniprot id: A0A8M3BEE2
uniprot id: A0A8M9QF19
uniprot id: A0A8M9QJE1
uniprot id: A0A8M9QN58
names: Similarity
messages: Belongs to the MAGUK family.

7955:akap12a
gene id: 7955:akap12a
uniprot id: A0A8M2B513
uniprot id: E7F983
names: Subcellular Location Annotation
messages: Membrane

7955:lepb
gene id: 7955:lepb
uniprot id: C4WYH6
names: Similarity
messages: Belongs to the leptin family.

7955:LOC100334818
gene id: 7955:LOC100334818
uniprot id: A0A8M1RRL5
uniprot id: F1QYH9
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:zgc:173585
gene id: 7955:zgc:173585
uniprot id: A7E2M8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:elp1
gene id: 7955:elp1
uniprot id: A0A0R4IJ07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

7955:eml2
gene id: 7955:eml2
uniprot id: Q4KMH7
names: Similarity
messages: Belongs to the WD repeat EMAP family.

7955:ppt2
gene id: 7955:ppt2
uniprot id: A0A8M9PAS0
uniprot id: A3KPZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

7955:si:dkey-27o4.1
gene id: 7955:si:dkey-27o4.1
uniprot id: A0A8N7UT19
uniprot id: E7F4B5
names: Similarity
messages: Belongs to the FAM83 family.

7955:nek3
gene id: 7955:nek3
uniprot id: A0A8M9PLB0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:lgi2b
gene id: 7955:lgi2b
uniprot id: Q2HPF8
names: Subcellular Location Annotation
messages: Secreted

7955:acmsd
gene id: 7955:acmsd
uniprot id: A4QP55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

7955:eif3hb
gene id: 7955:eif3hb
uniprot id: Q5PR67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

7955:med1
gene id: 7955:med1
uniprot id: A0A8M9PXG2
uniprot id: A0A8M9Q9D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

7955:myoz1a
gene id: 7955:myoz1a
uniprot id: Q6P0T8
names: Similarity
messages: Belongs to the myozenin family.

7955:LOC100500933
gene id: 7955:LOC100500933
uniprot id: A0A8M1NX86
uniprot id: A0A8M9PAS4
uniprot id: I3ITM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

7955:lama3
gene id: 7955:lama3
uniprot id: A0A2R8Q7H6
uniprot id: A0A8M9Q7C5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:il21
gene id: 7955:il21
uniprot id: A0A8M2BKC7
uniprot id: A1YYP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

7955:fam195b
gene id: 7955:fam195b
uniprot id: Q0P4B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: May play a role in the regulation of the epithelial-mesenchymal transition.
messages: Nucleus
messages: Stress granule

7955:parvg
gene id: 7955:parvg
uniprot id: A3KNP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

7955:zgc:162707
gene id: 7955:zgc:162707
uniprot id: A3KNX6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the UPF0524 family.
messages: Double knockout of c3orf70a and c3orf70b resulted in significantly decreased expression of the mature neuron markers elavl3 and eno2 and the midbrain/hindbrain marker irx3b. Neurobehaviors related to circadian rhythm and altered light-dark conditions were significantly impaired.
messages: Highly expressed in the gut, myotomes and brain, especially the midbrain and hindbrain, at 3 days post-fertilization (dpf).
messages: Plays a role in neuronal and neurobehavioral development (PubMed:31623237). Required for normal expression of the postmitotic and mature neuron markers elavl3 and eno2 and neurobehaviors related to circadian rhythm and altered light-dark conditions (PubMed:31623237).

7955:acot13
gene id: 7955:acot13
uniprot id: A0A8M2B6F6
uniprot id: F6P1Y9
uniprot id: Q1LWU4
names: Similarity
messages: Belongs to the thioesterase PaaI family.

7955:sept7b
gene id: 7955:sept7b
uniprot id: A0A8M1NZC4
uniprot id: A0A8M2B4V3
uniprot id: A0A8M2B5C8
uniprot id: A0A8M3AJH4
uniprot id: A0A8M3AR12
uniprot id: A0A8M3ATV2
uniprot id: A0A8M6Z1Q7
uniprot id: F8W5J3
uniprot id: Q4V8R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium axoneme
messages: kinetochore
messages: spindle

7955:pdyn
gene id: 7955:pdyn
uniprot id: A0A8M3AYT0
uniprot id: A0A8M3B6F1
uniprot id: F1R4H8
uniprot id: Q6JT77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

7955:aldh6a1
gene id: 7955:aldh6a1
uniprot id: Q6DHT4
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

7955:ano6
gene id: 7955:ano6
uniprot id: A0A8M2BBU6
uniprot id: A0A8M3AR51
uniprot id: F1QNZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

7955:rps10
gene id: 7955:rps10
uniprot id: Q7T1J9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

7955:chrnd
gene id: 7955:chrnd
uniprot id: Q75XT1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:rpgrip1
gene id: 7955:rpgrip1
uniprot id: A0A8M3B6J7
uniprot id: A0A8M6YWC7
uniprot id: A0A8M9PUA9
names: Similarity
messages: Belongs to the RPGRIP1 family.

7955:scamp4
gene id: 7955:scamp4
uniprot id: Q4V8U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

7955:sema3d
gene id: 7955:sema3d
uniprot id: A0A8N7UZF9
uniprot id: E9QD84
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:prdx5
gene id: 7955:prdx5
uniprot id: Q502C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

7955:chrm1a
gene id: 7955:chrm1a
uniprot id: A0A8M1Q6V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

7955:tspan17
gene id: 7955:tspan17
uniprot id: A0A8M9QAV9
uniprot id: B1H1G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:ndufa3
gene id: 7955:ndufa3
uniprot id: A0A8M1N1B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

7955:fam161a
gene id: 7955:fam161a
uniprot id: A0A8M9Q7G2
uniprot id: A0A8N7T6N8
names: Similarity
messages: Belongs to the FAM161 family.

7955:zgc:162592
gene id: 7955:zgc:162592
uniprot id: A3KNW1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:kcnq5a
gene id: 7955:kcnq5a
uniprot id: A0A8M9PYN5
uniprot id: A0A8M9QAC3
uniprot id: A0A8M9QG06
uniprot id: A0A8M9QK86
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:got1l1
gene id: 7955:got1l1
uniprot id: A0A8M1NIL9
uniprot id: B0UYT6
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

7955:LOC101886030
gene id: 7955:LOC101886030
uniprot id: A0A8M2BC78
names: Similarity
messages: Belongs to the copine family.

7955:rnf175
gene id: 7955:rnf175
uniprot id: A0A8M1P4N4
uniprot id: A0A8M1PH01
uniprot id: A0A8M9P7Z3
uniprot id: B8A5M0
uniprot id: F1QUH4
names: Subcellular Location Annotation
messages: Membrane

7955:tctex1d2
gene id: 7955:tctex1d2
uniprot id: F1QMY1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system (By similarity). Required for proper retrograde ciliary transport (PubMed:26044572).
messages: Belongs to the dynein light chain Tctex-type family.
messages: Dynein axonemal particle
messages: Morpholino knockdown of the protein produces a dose dependent typical ciliopathy phenotype, with ventrally curved body axis, hydrocephalus, abnormal otoliths and small eyes. The few embryos surviving to 4 days post fertilization display severe generalized edema, pronephric cysts, and defects of the craniofacial cartilage.

7955:oprd1b
gene id: 7955:oprd1b
uniprot id: B3DH72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:thraa
gene id: 7955:thraa
uniprot id: A0A8M2BB68
uniprot id: A0A8M3B8B2
uniprot id: B2GQG7
uniprot id: Q98867
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: After the mid-blastula transition (MBT), expressed throughout the deep cells, which give rise to the embryo proper. In adults, isoform 2 shows highest expression in the eye and liver. Expressed in adult gonads.
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Expressed both maternally and zygotically. Most abundant during early oogenesis during stages I and II, and expression levels drop by oocyte maturation. Expressed at the 1-cell stage and then again after the MBT from the blastula to early gastrula (shield) stages, during which expression levels decrease. Not detected after gastrulation until adults.
messages: High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development.
messages: Interacts with ncoa2.
messages: Nucleus
messages: The C-terminal extension present in isoform 1 and absent in isoform 2 (the F-domain) regulates transcriptional activity by altering the selectivity of binding to cofactors.

7955:sema5ba
gene id: 7955:sema5ba
uniprot id: A0A8M2BFB2
uniprot id: F1QPQ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:snap91
gene id: 7955:snap91
uniprot id: A0A8M2B4T0
uniprot id: A0A8M2B586
uniprot id: A0A8M3ATM5
uniprot id: A0A8M9PUY1
uniprot id: A0A8N7T6A8
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

7955:nppb
gene id: 7955:nppb
uniprot id: A0A8M1P3Q1
uniprot id: F1R8L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

7955:otud6b
gene id: 7955:otud6b
uniprot id: Q7ZV00
names: Function
messages: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of different cellular processes.

7955:si:ch211-39a7.1
gene id: 7955:si:ch211-39a7.1
uniprot id: A0A8M1NAA0
uniprot id: Q1L8Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:glod5
gene id: 7955:glod5
uniprot id: Q502D1
names: Similarity
messages: Belongs to the glyoxalase I family.

7955:LOC100332841
gene id: 7955:LOC100332841
uniprot id: A0A8M1REP1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:nipsnap2
gene id: 7955:nipsnap2
uniprot id: Q9PU58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NipSnap family.
messages: Cytoplasm

7955:src
gene id: 7955:src
uniprot id: A0A2R8QE56
uniprot id: A0A8M2BLD8
uniprot id: A0A8M6YVT4
uniprot id: A0A8M6Z3N7
uniprot id: B2GS52
uniprot id: Q1JPZ3
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Becomes activated when its major tyrosine phosphorylation site is not phosphorylated. It can also be activated by point mutations as well as by truncations at the C-terminal end or by other mutations. Heme regulates its activity by enhancing the phosphorylation on Tyr-528 (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Dephosphorylated at Tyr-528 by PTPRJ. Phosphorylated on Tyr-528 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. Dephosphorylated by PTPRJ at Tyr-417. Normally maintained in an inactive conformation with the SH2 domain engaged with Tyr-528, the SH3 domain engaged with the SH2-kinase linker, and Tyr-417 dephosphorylated. Dephosphorylation of Tyr-528 as a result of protein tyrosine phosphatase (PTP) action disrupts the intramolecular interaction between the SH2 domain and Tyr-528, Tyr-417 can then become autophosphorylated, resulting in SRC activation. Phosphorylation of Tyr-528 by CSK allows this interaction to reform, resulting in SRC inactivation (By similarity).
messages: Interacts with amotl2; this interaction promotes the translocation of phosphorylated src to peripheral cell-matrix adhesion sites.
messages: Mitochondrion inner membrane
messages: Myristoylated at Gly-2, and this is essential for targeting to membranes.
messages: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each src kinase is very difficult. Src appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of src to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including ptk2/fak1 and paxillin (pxn) (By similarity). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Involved in anchorage-independent cell growth (By similarity).
messages: Nucleus
messages: S-nitrosylation is important for activation of kinase activity.
messages: The SH2 and SH3 domains are important for the intramolecular and intermolecular interactions that regulate catalytic activity, localization, and substrate recruitment.
messages: Widely expressed.
messages: cytoskeleton
messages: focal adhesion
messages: perinuclear region

7955:aar2
gene id: 7955:aar2
uniprot id: F1R8D9
uniprot id: Q6GQL8
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

7955:cd81b
gene id: 7955:cd81b
uniprot id: B2GRC9
uniprot id: Q6AZB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:eny2
gene id: 7955:eny2
uniprot id: Q6DH42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates in a subcomplex of SAGA called the DUB module (deubiquitination module) (By similarity).
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
messages: nucleoplasm

7955:ca15a
gene id: 7955:ca15a
uniprot id: A0A8M6Z1Y2
uniprot id: A2VD39
uniprot id: F1Q816
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:smg5
gene id: 7955:smg5
uniprot id: F1R7R1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed during early cleavage, gastrulation and at 1 day post-fertilization.
messages: Morpholino knockdown leads to phenotypes ranging in severity from weak to severe that are developmentally delayed with disturbed brain patterning, necrosis in areas of the brain, aberrant eye development, impaired somitogenesis resulting in stacked somites, perturbed yolk sac extension and posterior axis extension with a high mortality rate of 88% at 5 days post-fertilization.
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay (By similarity). Does not have RNase activity by itself (By similarity). Promotes dephosphorylation of UPF1 (By similarity). Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). Necessary for TERT activity (By similarity). Required for normal embryonic development (PubMed:19414594).

7955:cbr1l
gene id: 7955:cbr1l
uniprot id: Q9DF44
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:exorh
gene id: 7955:exorh
uniprot id: Q9PTX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

7955:tjap1
gene id: 7955:tjap1
uniprot id: A0A8M9QNZ6
names: Subcellular Location Annotation
messages: Membrane

7955:limk1a
gene id: 7955:limk1a
uniprot id: A0A8M2BGY7
uniprot id: A0A8M2BHH8
uniprot id: Q0PWB7
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

7955:si:dkey-79i2.4
gene id: 7955:si:dkey-79i2.4
uniprot id: A0A8M1QKS9
uniprot id: A0A8M9PSD7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

7955:sez6l2
gene id: 7955:sez6l2
uniprot id: A0A8N7USW0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:ch211-107m4.1
gene id: 7955:si:ch211-107m4.1
uniprot id: A0A8N7TEL1
uniprot id: E9QBM3
names: Subcellular Location Annotation
messages: Nucleus

7955:trpm4b.2
gene id: 7955:trpm4b.2
uniprot id: A0A8N7XJG7
uniprot id: F1RC25
names: Subcellular Location Annotation
messages: Membrane

7955:slain1a
gene id: 7955:slain1a
uniprot id: A0A8M1N2B7
uniprot id: A0A8M2BFG7
uniprot id: A0A8M2BG17
uniprot id: A8WHU7
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

7955:rap2c
gene id: 7955:rap2c
uniprot id: Q5XJT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

7955:si:ch211-1o7.3
gene id: 7955:si:ch211-1o7.3
uniprot id: F1R1Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

7955:adgrf8
gene id: 7955:adgrf8
uniprot id: A0A8M9PHL8
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:LOC100534815
gene id: 7955:LOC100534815
uniprot id: A0A8M1RNB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actinoporin family. Sea anemone subfamily.
messages: Cell membrane
messages: Membrane
messages: Nematocyst
messages: Target cell membrane

7955:zgc:110319
gene id: 7955:zgc:110319
uniprot id: B8A6A3
uniprot id: Q6P002
names: Similarity
messages: Belongs to the NifU family.

7955:vegfc
gene id: 7955:vegfc
uniprot id: A0A8M2B6U8
uniprot id: A0A8M9PC47
uniprot id: A0A8M9PHS0
uniprot id: Q7T3I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

7955:LOC100334085
gene id: 7955:LOC100334085
uniprot id: A0A8M9PNU2
names: Similarity
messages: Belongs to the OSBP family.

7955:neto2
gene id: 7955:neto2
uniprot id: A0A8M9Q8U8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:erlin2
gene id: 7955:erlin2
uniprot id: A3QK16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Promotes sterol-accelerated ERAD of HMGCR. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway (By similarity).

7955:arrdc3b
gene id: 7955:arrdc3b
uniprot id: Q66L50
names: Similarity
messages: Belongs to the arrestin family.

7955:kank2
gene id: 7955:kank2
uniprot id: X1WE18
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in different biological processes including transcription and apoptosis by sequestering specific proteins outside of the nucleus (By similarity). Involved in actin stress fibers formation probably through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457).
messages: Mitochondrion
messages: Morpholino knockdown of the protein results in an edematous phenotype and proteinuria (PubMed:25961457). Podocyte foot process effacement and disorganization, rarefaction of slit membranes, and disorganization of the glomerular basement membrane in glomeruli which are characteritic of nephrosis are observed (PubMed:25961457).

7955:lztfl1
gene id: 7955:lztfl1
uniprot id: A0A8M2BHX5
uniprot id: Q7ZV21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

7955:tspan33a
gene id: 7955:tspan33a
uniprot id: Q5RH71
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Homodimer; disulfide-linked.
messages: Membrane

7955:slc24a4b
gene id: 7955:slc24a4b
uniprot id: A0A8M1RKZ5
uniprot id: F1QXK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

7955:rab4a
gene id: 7955:rab4a
uniprot id: B0V0U3
uniprot id: Q6PHI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasm
messages: Early endosome membrane
messages: Membrane
messages: Protein transport.
messages: Recycling endosome membrane
messages: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity).

7955:kti12
gene id: 7955:kti12
uniprot id: Q0P457
names: Similarity
messages: Belongs to the KTI12 family.

7955:b3gnt3
gene id: 7955:b3gnt3
uniprot id: A8KB44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:olfm2a
gene id: 7955:olfm2a
uniprot id: A0A286Y8W4
uniprot id: A0A8M2BB19
uniprot id: A0A8M3AR74
uniprot id: F1R5K6
uniprot id: Q803W5
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

7955:cdaa
gene id: 7955:cdaa
uniprot id: A0A8M1P5S0
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

7955:LOC101886393
gene id: 7955:LOC101886393
uniprot id: A0A8M2BJJ0
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

7955:si:dkey-159f12.2
gene id: 7955:si:dkey-159f12.2
uniprot id: A0A8M9QE68
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

7955:nr1h4
gene id: 7955:nr1h4
uniprot id: A0A8M2BHM4
uniprot id: Q6DGW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

7955:ghra
gene id: 7955:ghra
uniprot id: A4IG30
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

7955:ephx1
gene id: 7955:ephx1
uniprot id: Q7ZVB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

7955:itm2ba
gene id: 7955:itm2ba
uniprot id: Q803H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

7955:dpep2
gene id: 7955:dpep2
uniprot id: E7FBC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

7955:igf3
gene id: 7955:igf3
uniprot id: B0Z6G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

7955:peli1a
gene id: 7955:peli1a
uniprot id: A0A8M2B719
uniprot id: A0A8M9Q7P1
uniprot id: E7F5S3
names: Similarity
messages: Belongs to the pellino family.

7955:serpinb14
gene id: 7955:serpinb14
uniprot id: E7EXC4
names: Similarity
messages: Belongs to the serpin family.

7955:cd164l2
gene id: 7955:cd164l2
uniprot id: A0A8M9PGR0
uniprot id: I3IT20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

7955:vill
gene id: 7955:vill
uniprot id: A0A8M3AP84
uniprot id: A0A8M9P642
uniprot id: A0A8M9PGD1
uniprot id: A0A8M9PM91
uniprot id: E7FC92
names: Similarity
messages: Belongs to the villin/gelsolin family.

7955:inadl
gene id: 7955:inadl
uniprot id: A0A2R8QUA7
uniprot id: A0A8M2B8K6
uniprot id: A0A8M3AMY8
uniprot id: A0A8M3B5G9
uniprot id: Q1LXN3
names: Subcellular Location Annotation
messages: tight junction

7955:maea
gene id: 7955:maea
uniprot id: A0A8M9QG98
uniprot id: Q7SXR3
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity).
messages: Identified in the CTLH complex that contains at least MAEA, RMND5A, GID8, WDR26, and RANBP9 and/or RANBP10 as the catalytic core. Interacts with F-actin.
messages: Nucleus matrix
messages: The expected RING-type zinc finger domain is highly divergent and most of the expected Cys residues are not conserved. Still, the protein is required for CTLH complex E3 ubiquitin-protein transferase activity. In addition, the conserved Cys-314 in this highly divergent region is required for ubiquitination by the yeast GID complex, suggesting a direct role in catalyzing ubiquitination.
messages: cytoskeleton

7955:gstt2
gene id: 7955:gstt2
uniprot id: Q7SXG6
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

7955:sgip1b
gene id: 7955:sgip1b
uniprot id: A0A8M3AZW6
uniprot id: A0A8M6YVC9
uniprot id: A0A8M6Z197
names: Subcellular Location Annotation
messages: clathrin-coated pit

7955:ppp1r3ca
gene id: 7955:ppp1r3ca
uniprot id: F1QTC2
uniprot id: Q6DHT6
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

7955:LOC100150142
gene id: 7955:LOC100150142
uniprot id: A0A8M9PTR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

7955:smyhc3
gene id: 7955:smyhc3
uniprot id: B6IDE0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:epor
gene id: 7955:epor
uniprot id: Q2VBQ8
names: Subcellular Location Annotation
messages: Membrane

7955:myt1la
gene id: 7955:myt1la
uniprot id: A0A8M2B7M3
uniprot id: A0A8M3ALM3
uniprot id: A0A8M9P2M7
uniprot id: Q5TZG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

7955:map1lc3a
gene id: 7955:map1lc3a
uniprot id: Q6NX90
names: Similarity
messages: Belongs to the ATG8 family.

7955:zgc:114123
gene id: 7955:zgc:114123
uniprot id: Q4V8V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

7955:myrfl
gene id: 7955:myrfl
uniprot id: A0A8M1RS78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

7955:rhot2
gene id: 7955:rhot2
uniprot id: Q32LU1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
messages: Mitochondrion outer membrane
messages: Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.

7955:asah2
gene id: 7955:asah2
uniprot id: Q5W7F1
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the neutral ceramidase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Detected in intestine (at protein level).
messages: Expressed and active during embryonic development.
messages: Fishes display severe embryonic morphological and cellular abnormalities such as abnormal morphogenesis in the head and tail, pericardial edema, defect of blood cell circulation, and an increase of apoptotic cells, especially in the head and neural tube regions, at 36 hours post-fertilization.
messages: Golgi apparatus membrane
messages: Membrane raft
messages: Mitochondrion
messages: N-glycosylated.
messages: O-glycosylated.
messages: Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:15271994). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (By similarity). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity).
messages: caveola
messages: extracellular exosome

7955:tlr3
gene id: 7955:tlr3
uniprot id: Q32PW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

7955:rab13
gene id: 7955:rab13
uniprot id: Q7T3A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in endocytic recycling and may regulate the transport to the plasma membrane of transmembrane proteins. May regulate the assembly and the activity of tight junctions. May play a role in angiogenesis through regulation of endothelial cells chemotaxis. May be involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of glucose transporters.
messages: lamellipodium
messages: tight junction
messages: trans-Golgi network membrane

7955:dmc1
gene id: 7955:dmc1
uniprot id: Q50LF4
names: Similarity
messages: Belongs to the RecA family. DMC1 subfamily.

7955:mff
gene id: 7955:mff
uniprot id: A0A8M2B4M8
uniprot id: A0A8M2B4R4
uniprot id: A0A8M9QH49
uniprot id: Q7SZQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By similarity).
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

7955:rbm22
gene id: 7955:rbm22
uniprot id: Q6NZZ9
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLT11 family.
messages: Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex.
messages: Cytoplasm
messages: Maternally expressed. Expressed as early as the 1-cell stage and continued through the 8-cell and 32-cell stages and 15-hpf and 24-hpf stages.
messages: Nucleus
messages: Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle (By similarity). Required for normal early embryogenesis (PubMed:20013661).
messages: The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding.

7955:fam102aa
gene id: 7955:fam102aa
uniprot id: A0A8M1RF39
names: Similarity
messages: Belongs to the FAM102 family.

7955:arfgef2
gene id: 7955:arfgef2
uniprot id: A0A8M1RI19
uniprot id: E7FCG1
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

7955:uchl1
gene id: 7955:uchl1
uniprot id: Q7ZTI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:ola1
gene id: 7955:ola1
uniprot id: A0A8M9QA62
uniprot id: Q7ZU42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Nucleus
messages: nucleolus

7955:hmgn3
gene id: 7955:hmgn3
uniprot id: A0A8M1NZ58
uniprot id: A0A8M1P318
uniprot id: A7YYD1
uniprot id: E9QH74
uniprot id: Q5U381
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

7955:ccdc79
gene id: 7955:ccdc79
uniprot id: Q1LX29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TERB1 family.
messages: Component of the MAJIN-TERB1-TERB2 complex.
messages: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex.
messages: Nucleus inner membrane
messages: telomere

7955:bnip4
gene id: 7955:bnip4
uniprot id: A0A8M1PHK5
uniprot id: F1QZM4
uniprot id: Q32PK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

7955:onecut3a
gene id: 7955:onecut3a
uniprot id: A0A8N7T7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

7955:slc16a2
gene id: 7955:slc16a2
uniprot id: G8XYX6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Monomer (By similarity). Homodimer (By similarity). Homooligomer (By similarity).
messages: Morpholino knockdown of the protein alters the neural development in embryos.
messages: Preferentially expressed in the adult brain, gills, pancreas, liver, pituitary, heart, kidney and gut (PubMed:21952246). Widely expressed in the nervous system. Expressed in the vascular system and in neurons (PubMed:23161551).
messages: Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient (PubMed:21952246, PubMed:31436139). The substrate preference is 3,3-diiodothyronine (3,3'-T2) and T3 and to a lesser extentd T4 and rT3. Acts as a crucial regulator during embryonic development (PubMed:23161551).
messages: Ubiquitous expression during the bud stage in 10-hpf embryos. Later, at 24 hpf, mct8 is most abundant in the forebrain, midbrain, hindbrain, spinal cord, notochord, and eyes. At 48 hpf, mct8 expression is mainly observed in the brain and along the spinal cord.

7955:ddt
gene id: 7955:ddt
uniprot id: Q6IQL4
names: Similarity
messages: Belongs to the MIF family.

7955:LOC100003133
gene id: 7955:LOC100003133
uniprot id: A0A8M1PZM4
uniprot id: A0A8M3B5F9
uniprot id: E7F0X0
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tomm40
gene id: 7955:tomm40
uniprot id: A0A8M6Z1R1
uniprot id: Q7T314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:hist1h2ba
gene id: 7955:hist1h2ba
uniprot id: A7MCA7
uniprot id: Q5BJA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-111 promotes monoubiquitination of Lys-119. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-119 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ank3a
gene id: 7955:ank3a
uniprot id: A0A8M3AIV4
uniprot id: A0A8M3AIX2
uniprot id: A0A8M3AJR3
uniprot id: A0A8M3AJR9
uniprot id: A0A8M3AJS3
uniprot id: A0A8M3AJS7
uniprot id: A0A8M3AR97
uniprot id: A0A8M3ARA5
uniprot id: A0A8M3ARA9
uniprot id: A0A8M3ARB3
uniprot id: A0A8M3ARB6
uniprot id: A0A8M3AU68
uniprot id: A0A8M3AU73
uniprot id: A0A8M3AU79
uniprot id: A0A8M3B2A9
uniprot id: A0A8M3B2B6
uniprot id: A0A8M3B2C4
uniprot id: A0A8M9P0J3
uniprot id: A0A8M9PCL5
uniprot id: A0A8M9PET0
uniprot id: A0A8M9PPF5
uniprot id: A0A8M9PVB2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:LOC108191642
gene id: 7955:LOC108191642
uniprot id: A0A8M6Z8U1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rbpjb
gene id: 7955:rbpjb
uniprot id: A4FTT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

7955:rasgrp3
gene id: 7955:rasgrp3
uniprot id: A0A8M2B4V9
uniprot id: A4QNU6
uniprot id: F1QFI3
names: Similarity
messages: Belongs to the RASGRP family.

7955:rnf169
gene id: 7955:rnf169
uniprot id: E7FAP1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF169 family.
messages: Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage.
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif also mediates interaction with ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs) (By similarity).
messages: nucleoplasm

7955:immp1l
gene id: 7955:immp1l
uniprot id: A0A8M1PYZ0
uniprot id: E7FGX8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

7955:ptpn12
gene id: 7955:ptpn12
uniprot id: Q6PEI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
messages: Cytoplasm
messages: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.

7955:ets2
gene id: 7955:ets2
uniprot id: Q501S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:cdc7
gene id: 7955:cdc7
uniprot id: A0A8M2BID8
uniprot id: B0UYH9
uniprot id: Q5U3V5
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:LOC100536757
gene id: 7955:LOC100536757
uniprot id: A0A8M9Q9Z1
uniprot id: A0A8M9QIU5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:stag1a
gene id: 7955:stag1a
uniprot id: A0A8N7T7W9
uniprot id: F1QNA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

7955:gpr37l1a
gene id: 7955:gpr37l1a
uniprot id: A0A8N7TED3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:kif26aa
gene id: 7955:kif26aa
uniprot id: A0A8M3B220
uniprot id: A0A8N7UV77
uniprot id: F1QCX2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:uroc1
gene id: 7955:uroc1
uniprot id: B3DJ54
names: Similarity
messages: Belongs to the urocanase family.

7955:xpnpep2
gene id: 7955:xpnpep2
uniprot id: A0A8N1Z3N5
uniprot id: Q6ZM25
names: Similarity
messages: Belongs to the peptidase M24B family.

7955:hsbp1l1
gene id: 7955:hsbp1l1
uniprot id: A0A8M1NLU6
uniprot id: E7FEG7
names: Similarity
messages: Belongs to the HSBP1 family.

7955:ptpn11b
gene id: 7955:ptpn11b
uniprot id: Q7SY37
uniprot id: S6CMQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

7955:pex7
gene id: 7955:pex7
uniprot id: Q5BKX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

7955:chst2b
gene id: 7955:chst2b
uniprot id: A0A8M1QRB1
uniprot id: K7DYB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

7955:osbp
gene id: 7955:osbp
uniprot id: A0A8M1NRJ2
uniprot id: A0A8M2B705
uniprot id: A0A8M2B7B7
uniprot id: A0A8M3AKN2
uniprot id: A0A8M6YZQ9
uniprot id: A0A8M9PIA9
uniprot id: A0A8M9PVP0
uniprot id: A0A8M9Q1J6
uniprot id: A0A8M9Q6T9
uniprot id: A0A8M9QCC1
uniprot id: F6P8R2
names: Similarity
messages: Belongs to the OSBP family.

7955:plk4
gene id: 7955:plk4
uniprot id: A0A8M1NG63
uniprot id: A0A8M2B5U8
uniprot id: F1RB74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: centriole

7955:irx2a
gene id: 7955:irx2a
uniprot id: Q7SZP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7955:cmpk2
gene id: 7955:cmpk2
uniprot id: A0A8N7T8K9
names: Similarity
messages: Belongs to the thymidylate kinase family.

7955:slc6a13l
gene id: 7955:slc6a13l
uniprot id: A0A2R8QKW4
uniprot id: A0A8M2BDC6
uniprot id: A0A8M2BDF5
uniprot id: A0A8N7UYU1
uniprot id: F1Q5E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:ints10
gene id: 7955:ints10
uniprot id: A0A0R4IY98
uniprot id: A0A8M9PZ30
uniprot id: Q6TNU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 10 family.
messages: Belongs to the multiprotein complex Integrator.
messages: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
messages: Nucleus

7955:pi4kaa
gene id: 7955:pi4kaa
uniprot id: A0A8M2BJV9
uniprot id: A0A8M3AWF4
uniprot id: Q49GP4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:dmtn
gene id: 7955:dmtn
uniprot id: A0A8M2B209
uniprot id: A0A8M3BCX5
uniprot id: A0A8M9Q666
uniprot id: E7FCX5
names: Subcellular Location Annotation
messages: Cytoplasm

7955:sh3bgrl3
gene id: 7955:sh3bgrl3
uniprot id: Q7ZUC9
names: Similarity
messages: Belongs to the SH3BGR family.

7955:gmfg
gene id: 7955:gmfg
uniprot id: Q24JU9
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

7955:ednrab
gene id: 7955:ednrab
uniprot id: A0A8M1P7F8
uniprot id: F8W4W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

7955:zgc:110591
gene id: 7955:zgc:110591
uniprot id: Q7T392
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM179 family.
messages: Membrane

7955:agpat2
gene id: 7955:agpat2
uniprot id: A0JMM2
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

7955:LOC101883445
gene id: 7955:LOC101883445
uniprot id: A0A1L1QZE3
uniprot id: A0A8M3B0R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:gpr20
gene id: 7955:gpr20
uniprot id: A0A8M9PK33
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:ehf
gene id: 7955:ehf
uniprot id: A0A8M2B9Y6
uniprot id: A8E5B5
uniprot id: Q29R87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:mov10a
gene id: 7955:mov10a
uniprot id: A0A8M1RLW1
uniprot id: E7FAV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

7955:or106-2
gene id: 7955:or106-2
uniprot id: Q2PRL5
names: Subcellular Location Annotation
messages: Membrane

7955:cercam
gene id: 7955:cercam
uniprot id: E7F0F2
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

7955:aadac
gene id: 7955:aadac
uniprot id: A0A8M3B0M7
uniprot id: E7F2W1
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

7955:cdc42ep1a
gene id: 7955:cdc42ep1a
uniprot id: A0A8M9Q8Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

7955:inpp5jb
gene id: 7955:inpp5jb
uniprot id: A0A8M1RLT2
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

7955:esco1
gene id: 7955:esco1
uniprot id: A0A8M1RDQ8
uniprot id: A0A8M2BLF3
uniprot id: X1WEK0
names: Subcellular Location Annotation
messages: Nucleus

7955:vps53
gene id: 7955:vps53
uniprot id: A0A8M1N3K3
uniprot id: E7FAG0
uniprot id: F6P6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

7955:slc7a11
gene id: 7955:slc7a11
uniprot id: A0A140LGS0
uniprot id: A0A8M3B0I3
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch211-122f10.4
gene id: 7955:si:ch211-122f10.4
uniprot id: A0A8M1PU30
uniprot id: F1QYP6
names: Similarity
messages: Belongs to the peptidase S10 family.

7955:dact1
gene id: 7955:dact1
uniprot id: A0A8M1PR00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm

7955:pax6a
gene id: 7955:pax6a
uniprot id: A0A0R4IXU2
uniprot id: A0A8M3AP00
uniprot id: A0A8M3APL7
uniprot id: A0A8M3AWF6
uniprot id: A0A8M3AZJ7
uniprot id: A0A8M3B718
uniprot id: A0A8M6YYD0
uniprot id: A0A8M9P6C7
uniprot id: P26630
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Spatially restricted regions of the neural tube.
messages: Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development.

7955:lft1
gene id: 7955:lft1
uniprot id: Q9PW55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

7955:mmp13a
gene id: 7955:mmp13a
uniprot id: A0A8M1P6J4
uniprot id: A0A8M3AX13
uniprot id: F1QCX8
names: Similarity
messages: Belongs to the peptidase M10A family.

7955:gig2l
gene id: 7955:gig2l
uniprot id: E7FFW9
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:tut1
gene id: 7955:tut1
uniprot id: Q4KMD7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Belongs to the DNA polymerase type-B-like family.
messages: Binds 1 divalent cation per subunit.
messages: Nucleus speckle
messages: Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase.
messages: The RRM domain is required for terminal uridylyltransferase activity. Together with the zinc-finger domain, binds the 5'-area of U6 snRNA.
messages: The zinc-finger domain is required for terminal uridylyltransferase activity. Together with the RRM domain, binds the 5'-area of U6 snRNA.
messages: nucleolus

7955:lcat
gene id: 7955:lcat
uniprot id: A0A8M1P7R5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

7955:fam57ba
gene id: 7955:fam57ba
uniprot id: A0A8M2BB07
uniprot id: A0A8M2BB48
uniprot id: A0A8M2BBE5
uniprot id: F1QF55
uniprot id: Q6PBV7
uniprot id: X1WH51
names: Subcellular Location Annotation
messages: Membrane

7955:slc26a10
gene id: 7955:slc26a10
uniprot id: A0A8M1QQZ8
uniprot id: E7FF67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

7955:abi1a
gene id: 7955:abi1a
uniprot id: A0A2R8Q1F3
uniprot id: A0A2R8QEN6
uniprot id: A0A8M1PA08
uniprot id: A0A8M2B9B3
uniprot id: A0A8M2B9D1
uniprot id: A0A8M2B9D2
uniprot id: A0A8M2B9J6
uniprot id: A0A8M3AND6
uniprot id: A0A8M3AP19
uniprot id: A0A8M3B6H8
uniprot id: F1R187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

7955:dnm3a
gene id: 7955:dnm3a
uniprot id: A0A8M3AKP9
uniprot id: A0A8M6YU68
uniprot id: Q5RHR9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

7955:or123-1
gene id: 7955:or123-1
uniprot id: Q2PRA7
names: Subcellular Location Annotation
messages: Membrane

7955:cacybp
gene id: 7955:cacybp
uniprot id: Q6NYG2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

7955:zgc:103692
gene id: 7955:zgc:103692
uniprot id: Q5XJ46
names: Similarity
messages: Belongs to the TLS1 family.

7955:gpd1a
gene id: 7955:gpd1a
uniprot id: Q567A1
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

7955:supt6h
gene id: 7955:supt6h
uniprot id: A0A8M3AWY8
uniprot id: Q8UVK2
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Expressed throughout the blastoderm early in development. Highly expressed in the developing brain at 24 hours post-fertilization (hpf), and at lower levels in the rest of the embryo.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).
messages: Transcription elongation factor which binds histone H3 and enhances transcription elongation by RNA polymerase II (RNAPII). Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. Plays an important role during early patterning and somitogenesis of the embryo.

7955:nkain1
gene id: 7955:nkain1
uniprot id: Q6PHL4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Interacts with atp1b1 C-terminus.

7955:slc39a13
gene id: 7955:slc39a13
uniprot id: B3DG64
uniprot id: F1R7I6
uniprot id: Q8AW42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a zinc-influx transporter.
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane

7955:si:dkey-46g23.2
gene id: 7955:si:dkey-46g23.2
uniprot id: A0A8M9Q2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:cyb561a3a
gene id: 7955:cyb561a3a
uniprot id: A0A8M2BJJ7
uniprot id: A3KPR5
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme b groups non-covalently.
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis.

7955:zgc:86896
gene id: 7955:zgc:86896
uniprot id: A9JRP8
uniprot id: Q6IQ91
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

7955:myo15ab
gene id: 7955:myo15ab
uniprot id: A0A8M9Q2K6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:slc6a9
gene id: 7955:slc6a9
uniprot id: Q4FIV5
uniprot id: Q4FIV6
uniprot id: Q4FIV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

7955:ssh2a
gene id: 7955:ssh2a
uniprot id: A0A8M1QV03
uniprot id: A0A8M2B4L4
uniprot id: A0A8M9PIQ4
uniprot id: E7FH10
uniprot id: X1WFY2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

7955:parga
gene id: 7955:parga
uniprot id: A0A8N7UQU4
uniprot id: E7F2B6
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

7955:zgc:158225
gene id: 7955:zgc:158225
uniprot id: A0A8M2B8I3
uniprot id: A1L1P6
uniprot id: F1R3N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:jmjd4
gene id: 7955:jmjd4
uniprot id: Q08BY5
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.
messages: Cytoplasm

7955:srm
gene id: 7955:srm
uniprot id: A0A8M1PDY7
uniprot id: F1R3G8
uniprot id: Q7SY20
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

7955:dhrs7ca
gene id: 7955:dhrs7ca
uniprot id: Q5BL28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Putative oxidoreductase.
messages: Secreted

7955:dnajc19
gene id: 7955:dnajc19
uniprot id: Q6PBT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM14 family.
messages: Interacts with PHB2; the interaction associates DNAJC19 with the prohibitin complex. Interacts with TIMM16/PAM16 (By similarity). May be a component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity).
messages: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
messages: Mitochondrion inner membrane

7955:slco1f3
gene id: 7955:slco1f3
uniprot id: A0A0N4SU37
uniprot id: A0A8M1NIQ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:pus7
gene id: 7955:pus7
uniprot id: B1H1H9
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

7955:mtch2
gene id: 7955:mtch2
uniprot id: A0A8M9Q165
uniprot id: Q789I7
uniprot id: Q9PUL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:LOC108182776
gene id: 7955:LOC108182776
uniprot id: A0A8M9Q306
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:crhr2
gene id: 7955:crhr2
uniprot id: A8WG03
names: Subcellular Location Annotation
messages: Membrane

7955:slc2a15a
gene id: 7955:slc2a15a
uniprot id: A0A8M1NS42
uniprot id: A2CEX0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:trim71
gene id: 7955:trim71
uniprot id: A0A8M1P6Z4
names: Similarity
messages: Belongs to the TRIM/RBCC family.

7955:itga2b
gene id: 7955:itga2b
uniprot id: Q6EIY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:cracr2b
gene id: 7955:cracr2b
uniprot id: A1A600
names: Similarity
messages: Belongs to the EFCAB4 family.

7955:cst14a.1
gene id: 7955:cst14a.1
uniprot id: E7EYW5
names: Similarity
messages: Belongs to the cystatin family.

7955:si:ch211-203b20.7
gene id: 7955:si:ch211-203b20.7
uniprot id: A0A8M6YTH5
uniprot id: B0S551
uniprot id: F1QSW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:vsig10
gene id: 7955:vsig10
uniprot id: B0CLX4
names: Subcellular Location Annotation
messages: Membrane

7955:slc12a9
gene id: 7955:slc12a9
uniprot id: A0A8M9PY34
uniprot id: A2BFP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane
messages: Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function.

7955:atp5d
gene id: 7955:atp5d
uniprot id: Q6P1J5
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

7955:aco1
gene id: 7955:aco1
uniprot id: A0A8M2BJL9
uniprot id: F1QM42
uniprot id: Q3YMK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: cytosol

7955:gabrr1
gene id: 7955:gabrr1
uniprot id: A0A8M1N703
uniprot id: A0A8M2B753
uniprot id: Q5TZ16
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:tgif1
gene id: 7955:tgif1
uniprot id: Q6TNQ0
uniprot id: Q803F0
names: Subcellular Location Annotation
messages: Nucleus

7955:pycard
gene id: 7955:pycard
uniprot id: Q4VBV3
names: Subcellular Location Annotation
messages: Inflammasome

7955:histh1l
gene id: 7955:histh1l
uniprot id: Q568D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:LOC101882573
gene id: 7955:LOC101882573
uniprot id: A0A8M6Z698
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cdk5rap3
gene id: 7955:cdk5rap3
uniprot id: Q6IQA6
names: Similarity
messages: Belongs to the CDK5RAP3 family.

7955:uba2
gene id: 7955:uba2
uniprot id: A0A8M3ANZ0
uniprot id: A0A8M3AWE5
uniprot id: B2GQ09
uniprot id: Q7SXG4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Cytoplasm
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Heterodimer of sae1 and uba2/sae2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with ube2i (By similarity).
messages: Nucleus
messages: Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-237 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking (By similarity).
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
messages: The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

7955:tspy
gene id: 7955:tspy
uniprot id: A0A8M2BEB9
uniprot id: Q6PFI8
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7955:polr2d
gene id: 7955:polr2d
uniprot id: A0A8M1N062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

7955:slc25a5
gene id: 7955:slc25a5
uniprot id: A7MCM1
uniprot id: Q8JHI0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

7955:sybu
gene id: 7955:sybu
uniprot id: A0A8M2B4L2
uniprot id: D3KVM2
uniprot id: Q08CJ9
names: Subcellular Location Annotation
messages: Membrane

7955:obscnb
gene id: 7955:obscnb
uniprot id: A0A8M9PGJ4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

7955:panx1b
gene id: 7955:panx1b
uniprot id: A0A8M1NE09
uniprot id: F1QSR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

7955:mettl5
gene id: 7955:mettl5
uniprot id: F1QVR8
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (By similarity). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (By similarity).
messages: Expressed from 20 minutes after fertilization in embryos.
messages: Microcephaly and curved tails.
messages: Nucleus
messages: Postsynapse
messages: Presynapse
messages: rRNA N6-adenosine-methyltransferase activity is inhibited by zinc.

7955:tctex1d1
gene id: 7955:tctex1d1
uniprot id: Q66IC8
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7955:myh9b
gene id: 7955:myh9b
uniprot id: A0A8M1QUS6
uniprot id: A0A8M2BB06
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:gig2e
gene id: 7955:gig2e
uniprot id: A0A2R9YJN9
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:zgc:110286
gene id: 7955:zgc:110286
uniprot id: A0A8M3BDW3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7955:clpp
gene id: 7955:clpp
uniprot id: Q502B9
names: Similarity
messages: Belongs to the peptidase S14 family.

7955:nadl1.1
gene id: 7955:nadl1.1
uniprot id: A0A8M3AY05
uniprot id: Q6U7I5
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

7955:plag1
gene id: 7955:plag1
uniprot id: Q29YB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

7955:ube2w
gene id: 7955:ube2w
uniprot id: Q4VBH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrate and DNA repair.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Nucleus

7955:pvalb2
gene id: 7955:pvalb2
uniprot id: Q9I8V0
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity).

7955:urp2
gene id: 7955:urp2
uniprot id: Q199U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

7955:polr3h
gene id: 7955:polr3h
uniprot id: Q6DGK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

7955:cx28.9
gene id: 7955:cx28.9
uniprot id: Q5TYN9
uniprot id: Q5U3B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:aatf
gene id: 7955:aatf
uniprot id: A0A0R4IHH9
uniprot id: A0A8M1NDX7
uniprot id: A0A8M1P443
uniprot id: A0A8M2BCW8
uniprot id: F1R1W8
names: Similarity
messages: Belongs to the AATF family.

7955:lzts2b
gene id: 7955:lzts2b
uniprot id: A0A8M6Z909
uniprot id: E7EYJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

7955:rtn1b
gene id: 7955:rtn1b
uniprot id: A0A8M1P3N9
uniprot id: A0A8M2B7D0
uniprot id: A8E4S3
uniprot id: F1R540
uniprot id: Q4G5W6
uniprot id: Q5TZI1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:spns1
gene id: 7955:spns1
uniprot id: G1K2F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

7955:tnk2b
gene id: 7955:tnk2b
uniprot id: A0A0R4IH27
uniprot id: A0A8M1P4D8
uniprot id: A0A8M2BAU8
uniprot id: A0A8M9PXR5
uniprot id: A0A8M9QFB3
uniprot id: A0A8M9QJL9
uniprot id: A0A8M9QNC5
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

7955:ywhag2
gene id: 7955:ywhag2
uniprot id: E7F354
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

7955:spin1
gene id: 7955:spin1
uniprot id: A0A8M1PRR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

7955:tha1
gene id: 7955:tha1
uniprot id: A0A8M3AYK8
uniprot id: A0A8M9QMF1
uniprot id: Q6GQM4
names: Similarity
messages: Belongs to the threonine aldolase family.

7955:ndufa6
gene id: 7955:ndufa6
uniprot id: Q8AW03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

7955:zgc:103564
gene id: 7955:zgc:103564
uniprot id: B2GQ78
uniprot id: Q5U3G4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA (By similarity).
messages: Nucleus
messages: nucleolus

7955:mrpl34
gene id: 7955:mrpl34
uniprot id: A0A8M1NWF3
uniprot id: A0A8M1P1L9
uniprot id: E9QEZ5
uniprot id: E9QF21
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

7955:zgc:123305
gene id: 7955:zgc:123305
uniprot id: Q32LW1
names: Similarity
messages: Belongs to the lipin family.

7955:ifih1
gene id: 7955:ifih1
uniprot id: A0A0E3D804
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

7955:v2ra17
gene id: 7955:v2ra17
uniprot id: A0A8N7TDV0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:si:ch211-202h22.8
gene id: 7955:si:ch211-202h22.8
uniprot id: B8A4H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

7955:hs3st1l2
gene id: 7955:hs3st1l2
uniprot id: Q29RB5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:star
gene id: 7955:star
uniprot id: Q9DG10
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Highly expressed in the testis and at lower levels in the ovary, kidney and head.
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).

7955:chrna10a
gene id: 7955:chrna10a
uniprot id: A0A8M1N9D3
uniprot id: A0A8M9Q0E2
uniprot id: Q1LY90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:avd
gene id: 7955:avd
uniprot id: A0A8M1P1N5
names: Similarity
messages: Belongs to the avidin/streptavidin family.

7955:sorbs2b
gene id: 7955:sorbs2b
uniprot id: A0A8M9PZP0
uniprot id: A0A8M9PZQ6
uniprot id: A0A8M9PZR0
uniprot id: A0A8M9QBH3
uniprot id: A0A8M9QBI2
uniprot id: A0A8M9QBI6
uniprot id: A0A8M9QGP3
uniprot id: A0A8M9QGP8
uniprot id: A0A8M9QGQ4
uniprot id: A0A8M9QGR0
uniprot id: A0A8M9QKY3
uniprot id: A0A8M9QKZ0
uniprot id: A0A8M9QKZ3
uniprot id: A0A8M9QKZ6
uniprot id: A0A8M9QPF5
uniprot id: A0A8M9QPG1
uniprot id: A0A8M9QPG5
uniprot id: A0A8M9QPG7
names: Subcellular Location Annotation
messages: focal adhesion

7955:tns1b
gene id: 7955:tns1b
uniprot id: A0A8M9PT37
uniprot id: A0A8M9PT43
uniprot id: A0A8M9PT47
uniprot id: A0A8M9Q597
uniprot id: A0A8M9Q5A1
uniprot id: A0A8M9QBL0
uniprot id: A0A8M9QBL4
uniprot id: A0A8M9QG69
uniprot id: A0A8M9QG72
uniprot id: A0A8M9QKD3
uniprot id: A0A8M9QKD7
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

7955:zpr1
gene id: 7955:zpr1
uniprot id: Q7ZTY3
names: Similarity
messages: Belongs to the ZPR1 family.

7955:si:dkeyp-20g2.3
gene id: 7955:si:dkeyp-20g2.3
uniprot id: A0A0R4IL24
uniprot id: A0A8M2BCJ4
uniprot id: A0A8N7TFF4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

7955:proza
gene id: 7955:proza
uniprot id: F1Q5S2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pde2a
gene id: 7955:pde2a
uniprot id: A0A8M9PCP4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:nbeal2
gene id: 7955:nbeal2
uniprot id: E7FAW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat neurobeachin family.
messages: Endoplasmic reticulum
messages: Involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.

7955:cmtm7
gene id: 7955:cmtm7
uniprot id: A0A8M1NIL5
uniprot id: F1RD97
names: Subcellular Location Annotation
messages: Membrane

7955:LOC110440101
gene id: 7955:LOC110440101
uniprot id: A0A8M9Q7R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

7955:seta
gene id: 7955:seta
uniprot id: Q7ZUY0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7955:LOC100538279
gene id: 7955:LOC100538279
uniprot id: A0A8M9NZ60
uniprot id: A0A8M9PCZ8
names: Subcellular Location Annotation
messages: Membrane

7955:slc5a5
gene id: 7955:slc5a5
uniprot id: A0A8M9Q9Q5
uniprot id: A4IG60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7955:pitrm1
gene id: 7955:pitrm1
uniprot id: B2GRL2
uniprot id: Q7ZVZ6
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A disulfide bond locks the enzyme in the closed conformation preventing substrate entry into the catalytic chamber.
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Mainly exists in a closed and catalytically competent conformation but a closed-to-open switch allows substrate entry into the catalytic chamber. Substrate binding induces closure and dimerization. A disulfide bond may lock the enzyme in a closed conformation preventing substrate entry into the catalytic chamber, participating in redox regulation of the enzyme. Inhibited by metal-chelating agents. Inhibited by nickel and zinc excess, and slightly activated by manganese.
messages: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides.
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

7955:rxfp2b
gene id: 7955:rxfp2b
uniprot id: A0A8M1P9H8
uniprot id: F8W5N7
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:caska
gene id: 7955:caska
uniprot id: A0A8M6Z050
uniprot id: A0A8M6Z054
uniprot id: A0A8M6Z057
uniprot id: A0A8M6Z0S9
uniprot id: A0A8M6Z0T2
uniprot id: A0A8M6Z0T7
uniprot id: A0A8M6Z0U1
uniprot id: A0A8M6Z0U6
uniprot id: A0A8M6Z2G0
uniprot id: A0A8M6Z2G4
uniprot id: A0A8M6Z2G8
uniprot id: A0A8M6Z2H1
uniprot id: A0A8M6Z2H6
uniprot id: A0A8M6Z7Y8
uniprot id: A0A8M6Z7Z0
uniprot id: A0A8M6Z7Z3
uniprot id: A0A8M6Z7Z6
uniprot id: A0A8M6Z8C0
uniprot id: A0A8M6Z8C4
uniprot id: A0A8M6Z8C8
uniprot id: A0A8M6Z8D0
uniprot id: A0A8M9QF81
uniprot id: A0A8M9QJH6
uniprot id: B3DH78
uniprot id: Q910A4
names: Similarity
messages: Belongs to the MAGUK family.

7955:ric3b
gene id: 7955:ric3b
uniprot id: Q6DHE0
names: Similarity
messages: Belongs to the ric-3 family.

7955:kitlga
gene id: 7955:kitlga
uniprot id: Q56JH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Secreted
messages: filopodium
messages: lamellipodium

7955:zgc:56064
gene id: 7955:zgc:56064
uniprot id: A0A8M9PI57
uniprot id: Q7ZVE7
names: Similarity
messages: Belongs to the PPP phosphatase family.

7955:ovca2
gene id: 7955:ovca2
uniprot id: Q503Y4
names: Similarity
messages: Belongs to the LovG family.

7955:hoxb8a
gene id: 7955:hoxb8a
uniprot id: A0A8M2BJC8
uniprot id: Q8AWZ0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 6. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 3/somite 4 boundary; also expressed in bilateral domains adjacent to the anterior spinal cord and ventrally along the trunk in the pronephric ducts.
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:ndufa12
gene id: 7955:ndufa12
uniprot id: Q498W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

7955:zgc:162200
gene id: 7955:zgc:162200
uniprot id: A4IG44
names: Similarity
messages: Belongs to the BicD family.

7955:si:ch1073-159d7.9
gene id: 7955:si:ch1073-159d7.9
uniprot id: F1QTL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:eppk1
gene id: 7955:eppk1
uniprot id: A0A8M1P2Q9
uniprot id: I3ISA6
names: Subcellular Location Annotation
messages: cytoskeleton

7955:LOC110438835
gene id: 7955:LOC110438835
uniprot id: A0A8M9Q302
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

7955:LOC110438841
gene id: 7955:LOC110438841
uniprot id: A0A8M9PSM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7955:khdrbs2
gene id: 7955:khdrbs2
uniprot id: Q08BJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDRBS family.
messages: Nucleus
messages: RNA-binding protein that plays a role in the regulation of alternative splicing.

7955:eif1axa
gene id: 7955:eif1axa
uniprot id: Q5XJR0
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

7955:lygl2
gene id: 7955:lygl2
uniprot id: A0A0R4IJK7
uniprot id: A0A8M1RHM5
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

7955:si:dkey-145c18.3
gene id: 7955:si:dkey-145c18.3
uniprot id: A0A8M9PR57
names: Similarity
messages: Belongs to the NAPRTase family.

7955:scrn3
gene id: 7955:scrn3
uniprot id: A0A8M3B5C8
uniprot id: Q803W1
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

7955:hs6st3a
gene id: 7955:hs6st3a
uniprot id: A0A8M1PU32
uniprot id: F1Q9K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

7955:pnp6
gene id: 7955:pnp6
uniprot id: Q1LWJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

7955:ncaph2
gene id: 7955:ncaph2
uniprot id: Q5RH01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.
messages: Component of the condensin-2 complex, which contains the smc2 and smc4 heterodimer, and three non SMC subunits, ncapg2, ncaph2 and ncapd3 that probably regulate the complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture.

7955:ca9
gene id: 7955:ca9
uniprot id: A0A8M3B325
uniprot id: A0A8N7TDP2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:trpc4a
gene id: 7955:trpc4a
uniprot id: E7FGL3
uniprot id: U3N6S1
names: Subcellular Location Annotation
messages: Membrane

7955:lamb2
gene id: 7955:lamb2
uniprot id: A0A8M1P2Z5
uniprot id: A0A8M2B8V2
uniprot id: B7ZDA6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

7955:LOC100538283
gene id: 7955:LOC100538283
uniprot id: A0A8M3B1A9
names: Subcellular Location Annotation
messages: Membrane

7955:b4galt3
gene id: 7955:b4galt3
uniprot id: A0A8M3AMT1
uniprot id: A0A8M9PDW9
uniprot id: E7F264
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

7955:he1a
gene id: 7955:he1a
uniprot id: Q1LW00
uniprot id: Q4G0A2
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:ch211-217i17.1
gene id: 7955:si:ch211-217i17.1
uniprot id: A0A8M3BAQ3
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:mpp1
gene id: 7955:mpp1
uniprot id: Q6NWY1
names: Similarity
messages: Belongs to the MAGUK family.

7955:or110-2
gene id: 7955:or110-2
uniprot id: Q2PRK4
names: Subcellular Location Annotation
messages: Membrane

7955:arglu1b
gene id: 7955:arglu1b
uniprot id: Q7ZVW9
names: Similarity
messages: Belongs to the UPF0430 family.

7955:stag1b
gene id: 7955:stag1b
uniprot id: E7FC33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

7955:dlg4b
gene id: 7955:dlg4b
uniprot id: Q6R005
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: At 3 days-post-fertilization (dpf), expressed strongly in neurons in the ventral hindbrain and tegmentum and diffusely in the dorsal hindbrain and optic tectum. Also expressed in the diencephalon and the prospective olfactory bulb. Expression in non-spiny type-XIV tectal neurons is mostly diffuse. Over the next 7 days, as the dendritic arbor develops, expression becomes progressively more punctate, becoming localized to sites of synapse formation. At 4 dpf, expressed in the inner and outer plexiform layers of the retina and in the optic chiasm.
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: L27 domain is required for targeting to postsynaptic density.
messages: Palmitoylated. Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses.
messages: Postsynaptic density
messages: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins.
messages: Synapse
messages: Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis.

7955:LOC100149761
gene id: 7955:LOC100149761
uniprot id: A0A8M3AJF9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:si:ch211-110e21.3
gene id: 7955:si:ch211-110e21.3
uniprot id: E7FCK4
names: Subcellular Location Annotation
messages: Membrane

7955:si:dkey-22n8.3
gene id: 7955:si:dkey-22n8.3
uniprot id: A0A8M1RES1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion inner membrane

7955:or125-4
gene id: 7955:or125-4
uniprot id: Q2PRA3
names: Subcellular Location Annotation
messages: Membrane

7955:dnaaf3l
gene id: 7955:dnaaf3l
uniprot id: A0A8M1RPB5
uniprot id: I6L846
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF3 family.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

7955:cyb5d1
gene id: 7955:cyb5d1
uniprot id: Q567I9
names: Similarity
messages: Belongs to the cytochrome b5 family.

7955:iars
gene id: 7955:iars
uniprot id: A0A8N7UZX0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:slc8a4a
gene id: 7955:slc8a4a
uniprot id: A4UQV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

7955:slc16a1b
gene id: 7955:slc16a1b
uniprot id: Q7ZUL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

7955:LOC100334869
gene id: 7955:LOC100334869
uniprot id: A7MCA7
uniprot id: Q5BJA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-111 promotes monoubiquitination of Lys-119. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-119 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:si:dkey-88j15.3
gene id: 7955:si:dkey-88j15.3
uniprot id: A0A140LGH1
uniprot id: A0A8N7TB08
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:serpina1
gene id: 7955:serpina1
uniprot id: A0A8M6YU45
uniprot id: Q5SPJ4
names: Similarity
messages: Belongs to the serpin family.

7955:fat1b
gene id: 7955:fat1b
uniprot id: A0A140LGD3
uniprot id: A0A8M3AI02
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:jmjd1cb
gene id: 7955:jmjd1cb
uniprot id: A0A8M2B2R0
uniprot id: A0A8M2B2Y5
uniprot id: A0A8M3AY42
uniprot id: A0A8M3AY68
uniprot id: A0A8M3B4G8
uniprot id: A0A8M3B798
uniprot id: A0A8M3BE19
uniprot id: A0A8M6Z3J7
names: Subcellular Location Annotation
messages: Nucleus

7955:ppp2r2ba
gene id: 7955:ppp2r2ba
uniprot id: A0A0R4IJA2
uniprot id: A0A8M3AI53
uniprot id: A0A8M9PZZ4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

7955:chpfa
gene id: 7955:chpfa
uniprot id: A0A8M1RR72
uniprot id: F1R7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7955:glsb
gene id: 7955:glsb
uniprot id: A0A8M2BFC6
uniprot id: A0A8M2BFD6
uniprot id: A0A8M2BFD7
uniprot id: A0A8N7TDH1
uniprot id: F1RDU2
names: Similarity
messages: Belongs to the glutaminase family.

7955:tpma
gene id: 7955:tpma
uniprot id: P13104
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
messages: Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: cytoskeleton

7955:pnpt1
gene id: 7955:pnpt1
uniprot id: G5CTT5
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

7955:ampd2b
gene id: 7955:ampd2b
uniprot id: A0A8M3AV69
uniprot id: A0A8M9QA40
uniprot id: A0A8M9QIZ0
uniprot id: B8JIS9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

7955:kitb
gene id: 7955:kitb
uniprot id: A0A8M1NPF4
uniprot id: B8A5K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:LOC101882899
gene id: 7955:LOC101882899
uniprot id: A0A8M2BBI0
uniprot id: A0A8M3AR63
names: Function
messages: In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits.

7955:ssr4
gene id: 7955:ssr4
uniprot id: Q6IQ57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

7955:ehhadh
gene id: 7955:ehhadh
uniprot id: Q6NYL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: Monomer.
messages: Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long straight chain fatty acids peroxisomal beta-oxidation pathway (By similarity). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (By similarity). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species. Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (By similarity).
messages: Peroxisome

7955:LOC110437808
gene id: 7955:LOC110437808
uniprot id: A0A8M9NZR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

7955:vtg7
gene id: 7955:vtg7
uniprot id: A0A8M9PJK1
uniprot id: A3KMS4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:or104-1
gene id: 7955:or104-1
uniprot id: Q2PRL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:timm10b
gene id: 7955:timm10b
uniprot id: Q568N4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force.
messages: Component of the TIM22 complex.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of timm10b from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.

7955:zgc:101569
gene id: 7955:zgc:101569
uniprot id: A0A8M1N2N9
uniprot id: A0A8M1NYS5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

7955:acsf2
gene id: 7955:acsf2
uniprot id: F1R1C0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:cnot10
gene id: 7955:cnot10
uniprot id: A0A8M2B459
uniprot id: A0A8M2B486
uniprot id: E7FA32
uniprot id: Q08CL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).
messages: Component of the CCR4-NOT complex. cnot10 and cnot11 form a subcomplex docked to the cnot1 scaffold (By similarity).
messages: Cytoplasm
messages: Nucleus

7955:or115-13
gene id: 7955:or115-13
uniprot id: A0A8M2B8M8
uniprot id: A5PLJ0
uniprot id: Q2PRI5
names: Subcellular Location Annotation
messages: Membrane

7955:grb14
gene id: 7955:grb14
uniprot id: A0A8M9QGA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

7955:hnf4b
gene id: 7955:hnf4b
uniprot id: Q6P0E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:LOC110437915
gene id: 7955:LOC110437915
uniprot id: A0A8M9P7F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:sec16b
gene id: 7955:sec16b
uniprot id: A0A0R4IJF7
uniprot id: A0A8N7TCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:adra2a
gene id: 7955:adra2a
uniprot id: A0A8N7V090
uniprot id: Q1L8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:aacs
gene id: 7955:aacs
uniprot id: A3QK15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity).
messages: cytosol

7955:c6ast1
gene id: 7955:c6ast1
uniprot id: Q14TH1
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:slc37a4b
gene id: 7955:slc37a4b
uniprot id: F1QPV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

7955:atp13a3
gene id: 7955:atp13a3
uniprot id: A0A8M3AXS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

7955:slc6a8
gene id: 7955:slc6a8
uniprot id: A0A8M1P953
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:en2b
gene id: 7955:en2b
uniprot id: P31533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the engrailed homeobox family.
messages: Nucleus

7955:taar19c
gene id: 7955:taar19c
uniprot id: A0A2R8QAB2
uniprot id: A0A8M3BDC4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:lhx1b
gene id: 7955:lhx1b
uniprot id: O13106
names: Subcellular Location Annotation
messages: Nucleus

7955:sepp1a
gene id: 7955:sepp1a
uniprot id: A0A8M1PAF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein P family.
messages: Secreted

7955:LOC100536376
gene id: 7955:LOC100536376
uniprot id: A0A8M9Q112
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:atxn2l
gene id: 7955:atxn2l
uniprot id: A0A8M2BBA5
uniprot id: A0A8M3AQQ2
uniprot id: F1QA42
uniprot id: Q6PFI6
names: Similarity
messages: Belongs to the ataxin-2 family.

7955:si:dkeyp-94b4.1
gene id: 7955:si:dkeyp-94b4.1
uniprot id: A0A0R4ICW1
uniprot id: A0A8M3AY87
uniprot id: A0A8M3B4H9
uniprot id: A0A8M9PWX9
names: Similarity
messages: Belongs to the villin/gelsolin family.

7955:sacm1lb
gene id: 7955:sacm1lb
uniprot id: A1L244
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2).

7955:zgc:110410
gene id: 7955:zgc:110410
uniprot id: A0A2R8PVR6
uniprot id: A0A8M1P9U8
uniprot id: A0A8M2B4F5
uniprot id: A0A8M3AQH9
uniprot id: Q503N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7955:hddc2
gene id: 7955:hddc2
uniprot id: Q1LUI2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Binds 2 divalent metal cations (By similarity). Shows activity with Mn(2+), Co(2+) and Mg(2+) but shows no activity with Zn(2+) (By similarity).
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

7955:snx13
gene id: 7955:snx13
uniprot id: A0A8M9P265
uniprot id: A0A8M9PBA8
uniprot id: A0A8M9PGV3
uniprot id: A0A8M9PS53
names: Similarity
messages: Belongs to the sorting nexin family.

7955:ecsit
gene id: 7955:ecsit
uniprot id: F1QSV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

7955:peli2
gene id: 7955:peli2
uniprot id: Q6DHJ8
names: Similarity
messages: Belongs to the pellino family.

7955:si:dkey-239i20.4
gene id: 7955:si:dkey-239i20.4
uniprot id: Q08BI3
uniprot id: Q5TZD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

7955:pcnt
gene id: 7955:pcnt
uniprot id: A0A8M1P4C4
uniprot id: A0A8M1RDI9
uniprot id: A0A8M9Q5Z1
uniprot id: A0A8M9QF75
uniprot id: I3ISP1
names: Subcellular Location Annotation
messages: centrosome

7955:si:dkeyp-14d3.1
gene id: 7955:si:dkeyp-14d3.1
uniprot id: A0A8M3AVE3
uniprot id: F1RAQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

7955:rpe65c
gene id: 7955:rpe65c
uniprot id: A9C3R8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes both 11-cis retinol and 13-cis retinol, 2 stereoisomeric forms of retinoic acid from all-trans-retinyl ester. Acts as an alternative isomerohydrolase in retinal Mueller cells by catalyzing formation of 11-cis retinol, to meet the high demand for the chromophore by cones (PubMed:21676174). Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Palmitoylated.
messages: Retinal Mueller cells. Detected in the inner retina near the ganglion cell layer, in a region where the Mueller end feet are located, and a weak signal is observed between the outer nuclear and ganglion cell layers (at protein level).

7955:cacna1sb
gene id: 7955:cacna1sb
uniprot id: Q6RKB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

7955:btbd6a
gene id: 7955:btbd6a
uniprot id: A9JRD8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein for the cul3 E3 ubiquitin-protein ligase complex. Promotes the export of zbtb16/plzf from the nucleus to the cytoplasm and targets zbtb16/plzf for ubiquitination and degradation. Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote neurogenesis.
messages: Cytoplasm
messages: Expressed during primary neurogenesis. At the 3 somite stage (3s), expressed in rostrocaudal stripes in the posterior neural plate characteristic of the lateral zone, intermediate zone, and medial zone of primary neurogenesis. At 14s and 20 hpf, widely expressed in the spinal cord. By 24 hpf, becomes restricted to the posterior spinal cord. Expression also occurs in a dynamic segmental pattern in the hindbrain, at the mid-hindbrain boundary, cranial ganglia, midbrain, and forebrain. Isoform 1: Expressed throughout early development. Isoform 2: up-regulated from 9 hpf, when neurogenesis is initiated.
messages: Expressed in the developing central nervous system.
messages: Interacts with cul3. Interacts (via BTB domain) with zbtb16/plzf.
messages: Morpholino knockdown of both isoform 1 and isoform 2 leads to a major decrease in the expression of neurog1 and downstream markers of neuronal differentiation. Knockdown of either isoform alone leads to a mild decrease in the expression of late markers of neurogenesis, but has no detectable effect on neurog1 expression.
messages: Nucleus

7955:lclat1
gene id: 7955:lclat1
uniprot id: Q6NYV8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (By similarity). Required for establishment of the hematopoietic and endothelial lineages (PubMed:18388326).
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

7955:drd4a
gene id: 7955:drd4a
uniprot id: A0A0R4IR92
uniprot id: A0A2R8RMG6
uniprot id: A0A8M1N4C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:erc1a
gene id: 7955:erc1a
uniprot id: A0A0R4IEU4
uniprot id: A0A8M3APQ9
uniprot id: A0A8M3AWL1
uniprot id: A0A8M3AZP8
uniprot id: A0A8M9P6F0
uniprot id: A0A8M9PUX5
uniprot id: Q5BQP2
names: Subcellular Location Annotation
messages: Cytoplasm

7955:bnip3
gene id: 7955:bnip3
uniprot id: A0A8M2BKA1
uniprot id: Q5VK50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

7955:vcam1a
gene id: 7955:vcam1a
uniprot id: A0A8M9PMN1
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100329773
gene id: 7955:LOC100329773
uniprot id: A0A8M2BKB3
names: Similarity
messages: Belongs to the TMEM121 family.

7955:ndnfl
gene id: 7955:ndnfl
uniprot id: A0A8M9PLF7
names: Subcellular Location Annotation
messages: Secreted

7955:si:dkey-258f14.3
gene id: 7955:si:dkey-258f14.3
uniprot id: A0A8M9QE15
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:panx1a
gene id: 7955:panx1a
uniprot id: Q7ZUN0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: S-nitrosylation inhibits channel currents and ATP release.
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

7955:jph1b
gene id: 7955:jph1b
uniprot id: Q1ECU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

7955:plaub
gene id: 7955:plaub
uniprot id: A0A8M9Q858
uniprot id: G8CXX6
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

7955:LOC110439895
gene id: 7955:LOC110439895
uniprot id: A0A8M9Q1M4
names: Subcellular Location Annotation
messages: Membrane

7955:si:dkey-251i10.3
gene id: 7955:si:dkey-251i10.3
uniprot id: A0A8M1P3I4
uniprot id: A0A8M2BCW9
uniprot id: A2CEY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

7955:stam
gene id: 7955:stam
uniprot id: A0A8M2BAS4
uniprot id: A5PMY5
uniprot id: Q7ZVR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane

7955:pacsin1b
gene id: 7955:pacsin1b
uniprot id: B2GTA5
uniprot id: Q4V920
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in cellular transport processes by recruiting dynamins to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with cobl, and by recruiting cobl to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Required for normal embryonic development, including normal development of laterality, normal body size and shape, as well as normal brain and heart development. Required for normal development of stereocilia and kinocilia in sensory hair cells of neuromasts in the posterior lateral line organ, and thus also for balance keeping and normal swimming behavior.
messages: Cell membrane
messages: Cell projection
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Highly expressed throughout embryogenesis, from fertilization to hatching. Detected in embryonic neuronal tissues, including forebrain, hindbrain, spinal cord and retina.
messages: Interacts with cobl.
messages: Membrane
messages: Synapse
messages: The F-BAR domain mediates membrane-binding and membrane tubulation.
messages: cytosol
messages: ruffle membrane
messages: synaptosome

7955:ror2
gene id: 7955:ror2
uniprot id: E7FCE4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:LOC553450
gene id: 7955:LOC553450
uniprot id: A0A8M6YZ29
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:eif1b
gene id: 7955:eif1b
uniprot id: Q7ZUI8
names: Similarity
messages: Belongs to the SUI1 family.

7955:gria2a
gene id: 7955:gria2a
uniprot id: A0A8M2BI34
uniprot id: A0A8M2BI57
uniprot id: A0A8M2BIL5
uniprot id: Q71E63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:syngr2a
gene id: 7955:syngr2a
uniprot id: A1L1F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

7955:LOC101885014
gene id: 7955:LOC101885014
uniprot id: A0A8M1P332
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Mitochondrion outer membrane

7955:sec61a1l
gene id: 7955:sec61a1l
uniprot id: A0A0J9YIG5
uniprot id: Q90YL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
messages: Membrane

7955:wu:fj19g03
gene id: 7955:wu:fj19g03
uniprot id: A0A8M9QGP2
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

7955:tspan7
gene id: 7955:tspan7
uniprot id: Q7SXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:ctbp2a
gene id: 7955:ctbp2a
uniprot id: Q5BU19
uniprot id: Q9DEG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

7955:acvr2aa
gene id: 7955:acvr2aa
uniprot id: A0A8M1NG95
uniprot id: A0A8M2BFL8
uniprot id: A0A8M9PS26
uniprot id: A0A8M9QFD6
uniprot id: F1QG01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:LOC110438157
gene id: 7955:LOC110438157
uniprot id: A0A8M9PPE2
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:dgkza
gene id: 7955:dgkza
uniprot id: A0A1D5NSE1
uniprot id: A0A8M1QKR7
uniprot id: A0A8M2BGB6
uniprot id: A0A8M2BGE2
uniprot id: A0A8M2BGZ7
uniprot id: A0A8M3B4A5
uniprot id: A0A8M9Q2N7
uniprot id: A0A8M9Q8U0
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

7955:tmem177
gene id: 7955:tmem177
uniprot id: Q6PBI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM177 family.
messages: Mitochondrion inner membrane
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

7955:vgll4l
gene id: 7955:vgll4l
uniprot id: Q1RLU0
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

7955:or125-1
gene id: 7955:or125-1
uniprot id: Q2PRA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:cpeb1a
gene id: 7955:cpeb1a
uniprot id: A0A8M3ANW5
uniprot id: Q9YGX4
names: Similarity
messages: Belongs to the RRM CPEB family.

7955:si:dkey-171o17.8
gene id: 7955:si:dkey-171o17.8
uniprot id: A0A8M1NDW8
uniprot id: A5WWK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

7955:tubb5
gene id: 7955:tubb5
uniprot id: A0A8M2BKU1
uniprot id: Q6NW90
uniprot id: Q6TGS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:mmp24
gene id: 7955:mmp24
uniprot id: A0A8N7UTI0
uniprot id: E9QIX9
names: Similarity
messages: Belongs to the peptidase M10A family.

7955:grb10a
gene id: 7955:grb10a
uniprot id: A0A8M6YWC5
uniprot id: Q68EG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

7955:helz
gene id: 7955:helz
uniprot id: Q6NYU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: May act as a helicase.
messages: Nucleus

7955:zgc:165481
gene id: 7955:zgc:165481
uniprot id: A5PLA6
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

7955:ndufa2
gene id: 7955:ndufa2
uniprot id: Q4VBI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

7955:dnmbp
gene id: 7955:dnmbp
uniprot id: A0A8M2B2P0
uniprot id: A0A8M2B371
uniprot id: A0A8M3AYH8
uniprot id: E7F1U2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell junction
messages: Cytoplasm
messages: Expressed from 1 dpf in the brain and pronephric tubules. At 3 dpf, expression expanded to the eyes and neuromasts, where mechanosensory hair cells exist, along the lateral line.
messages: Golgi stack
messages: Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton (By similarity) (PubMed:26895965). Plays a central role in renal ciliogenesis and kidney development (PubMed:26895965).
messages: Synapse
messages: The morphants contained multiple phenotypic defects, beginning with a downward-curled tail at 2 dpf. Additional ciliary defects after 3 dpf included small eyes, pericardial edema and hydrocephalus. These defects became more severe, leading to abdominal fluid accumulation, as well as abnormal pronephric kidneys at 5 dpf.
messages: cytoskeleton

7955:eif2b2
gene id: 7955:eif2b2
uniprot id: Q6NXC7
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

7955:rnft1
gene id: 7955:rnft1
uniprot id: Q6NZ21
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.
messages: Endoplasmic reticulum membrane

7955:edf1
gene id: 7955:edf1
uniprot id: Q6PBY3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable transcriptional coactivator.

7955:stx2a
gene id: 7955:stx2a
uniprot id: A0A8M2B849
uniprot id: E9QCC0
uniprot id: Q6DEJ2
names: Similarity
messages: Belongs to the syntaxin family.

7955:ruvbl1
gene id: 7955:ruvbl1
uniprot id: Q6IQT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

7955:abi2b
gene id: 7955:abi2b
uniprot id: A0A8M2BD18
uniprot id: A0A8M2BD24
uniprot id: A0A8M2BD25
uniprot id: A0A8M2BD58
uniprot id: A0A8M2BDA0
uniprot id: A0A8M2BDA6
uniprot id: A0A8M3AT64
uniprot id: A0A8M9PM97
uniprot id: A0A8M9PZX3
uniprot id: A0A8M9Q683
uniprot id: A0A8M9QAG4
uniprot id: A0A8M9QAG8
uniprot id: A0A8M9QFJ3
uniprot id: I3IRV8
uniprot id: I3IS53
uniprot id: I3ITI8
uniprot id: Q1JPU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

7955:mych
gene id: 7955:mych
uniprot id: B2KUA9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
messages: Nucleus
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.

7955:dennd5a
gene id: 7955:dennd5a
uniprot id: A0A2R8QFR0
uniprot id: A0A8M1Q7I4
uniprot id: A0A8M2BE62
uniprot id: A0A8M3AUQ3
uniprot id: A0A8M3B1L1
uniprot id: E7F1J4
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC561000
gene id: 7955:LOC561000
uniprot id: A0A8M2BKT0
uniprot id: A0A8N7TAY6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:adck4
gene id: 7955:adck4
uniprot id: A0A8M9NYH4
uniprot id: A0A8M9PIF5
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

7955:mrpl15
gene id: 7955:mrpl15
uniprot id: B2GNQ7
uniprot id: Q6DGM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

7955:pvalb8
gene id: 7955:pvalb8
uniprot id: Q5U3P2
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

7955:zgc:171779
gene id: 7955:zgc:171779
uniprot id: A7MBZ6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

7955:eva1ba
gene id: 7955:eva1ba
uniprot id: A4QNW5
uniprot id: F1QWY0
names: Similarity
messages: Belongs to the EVA1 family.

7955:si:dkey-187j14.4
gene id: 7955:si:dkey-187j14.4
uniprot id: A0A8M1Q2A9
uniprot id: F1QVS2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:grpel2
gene id: 7955:grpel2
uniprot id: A0A8M1P5R5
uniprot id: E7F0C3
names: Similarity
messages: Belongs to the GrpE family.

7955:ta
gene id: 7955:ta
uniprot id: Q07998
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By mesoderm-inducing factor activin A.
messages: First expressed at the dorsal side of the blastula embryo. Expressed in the germ ring, shield and chordamesoderm during gastrulation and is restricted to the notochord and tailbud during somitogenesis (at protein level).
messages: In the embryo, first expressed at the doming stage (4.2 hours). Highest expression is found between 5.2 and 9.5 hours (epiboly) after which levels gradually decrease, with expression becoming absent by 48 hours.
messages: Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail formation. Required for the morphogenesis of Kupffer's vesicle and regulates left-right asymmetry.
messages: Loss of notochord cells and posterior structures. Disrupts left-right development.
messages: Monomer. Binds DNA as a monomer.
messages: Nucleus

7955:zgc:112052
gene id: 7955:zgc:112052
uniprot id: A8KC47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

7955:dclk1a
gene id: 7955:dclk1a
uniprot id: A0A8M3AWX7
uniprot id: B2GSP8
uniprot id: E9QBD0
uniprot id: Q08BH4
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

7955:jak2a
gene id: 7955:jak2a
uniprot id: A0A8M3ATI4
uniprot id: F1QWX8
uniprot id: O93596
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system

7955:adck5
gene id: 7955:adck5
uniprot id: A0A8M1NYL2
uniprot id: A0A8M3ASF6
uniprot id: F1Q5S6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

7955:ccnl1a
gene id: 7955:ccnl1a
uniprot id: A4QP43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

7955:anxa1b
gene id: 7955:anxa1b
uniprot id: Q804H1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: cilium

7955:yipf5
gene id: 7955:yipf5
uniprot id: Q6P5I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endoplasmic reticulum membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.
messages: cis-Golgi network membrane

7955:mlnr
gene id: 7955:mlnr
uniprot id: A0A8M1RMH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:lamtor1
gene id: 7955:lamtor1
uniprot id: A0A8M1P653
uniprot id: E7FBZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

7955:si:dkey-84o3.2
gene id: 7955:si:dkey-84o3.2
uniprot id: A0A8M2B858
uniprot id: A0A8M9PUB5
uniprot id: E9QFX7
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:slc5a9
gene id: 7955:slc5a9
uniprot id: A0A8M3B1U3
uniprot id: A8WHP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane
messages: Probable sodium-dependent sugar transporter.

7955:baz1b
gene id: 7955:baz1b
uniprot id: A0A8M1P9M0
names: Subcellular Location Annotation
messages: Nucleus

7955:stn1
gene id: 7955:stn1
uniprot id: B8JKF4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTC1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Morpholino knockdown in embryos results in decreased red blood cells and an arrest in T-cell progenitors, as well as increased vascularity. The vascular defects could be rescued by wild-type gene and by thalidomide treatment.
messages: Nucleus
messages: telomere

7955:LOC100334599
gene id: 7955:LOC100334599
uniprot id: Q7ZT21
names: Similarity
messages: Belongs to the globin family.

7955:mcoln3a
gene id: 7955:mcoln3a
uniprot id: A0A8M1RSC3
uniprot id: A0A8M9P7U6
uniprot id: E7FE44
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

7955:fat3a
gene id: 7955:fat3a
uniprot id: A0A2R8QAL3
uniprot id: A0A8M1NBU7
uniprot id: A0A8M6YUT6
uniprot id: A0A8M6Z1C0
uniprot id: A0A8M9Q0H4
uniprot id: A0A8M9QLG7
uniprot id: A0A8M9QPX2
uniprot id: F1QA09
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cx52.7
gene id: 7955:cx52.7
uniprot id: B0FL75
uniprot id: B3DJY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:esco2
gene id: 7955:esco2
uniprot id: A0A8M2B7P6
uniprot id: Q5SPR8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development (PubMed:15256591).
messages: Belongs to the acetyltransferase family. ECO subfamily.
messages: Chromosome
messages: Nucleus
messages: The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process.

7955:kctd6b
gene id: 7955:kctd6b
uniprot id: Q6DG99
names: Function
names: Subunit
messages: Homopentamer. May be part of a cullin-containing E3 ubiquitin-protein ligase complex.
messages: Probable substrate-specific adapter of a cullin-containing E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins.

7955:ptprnb
gene id: 7955:ptprnb
uniprot id: A0A8M2BD60
uniprot id: A0A8N7UV08
uniprot id: X1WH84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

7955:kcnh4b
gene id: 7955:kcnh4b
uniprot id: A0A8M6Z211
uniprot id: E7FB36
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

7955:LOC108183426
gene id: 7955:LOC108183426
uniprot id: A0A8M6Z5K6
names: Similarity
messages: Belongs to the NLRP family.

7955:taf7
gene id: 7955:taf7
uniprot id: Q8JHG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

7955:kcnma1a
gene id: 7955:kcnma1a
uniprot id: A0A2R8QRZ7
uniprot id: A0A8M1NRK6
uniprot id: A0A8M2B2Q5
uniprot id: A0A8M2B2Q8
uniprot id: A0A8M2B2S7
uniprot id: A0A8M2B2T1
uniprot id: A0A8M2B2T7
uniprot id: A0A8M2B2Z4
uniprot id: A0A8M2B2Z8
uniprot id: A0A8M2B303
uniprot id: A0A8M2B3E8
uniprot id: A0A8M2B3F4
uniprot id: A0A8M2B3J8
uniprot id: A0A8M2B3K4
uniprot id: A0A8M3AYZ7
uniprot id: A0A8M3AZ02
uniprot id: A0A8M3AZ19
uniprot id: A0A8M3AZ25
uniprot id: A0A8M3B560
uniprot id: A0A8M3B563
uniprot id: A0A8M3B7Y4
uniprot id: A0A8M3B7Y9
uniprot id: A0A8M3BEL0
uniprot id: A0A8M6Z1R0
uniprot id: A0A8M6Z2C3
uniprot id: A0A8M6Z3V4
uniprot id: A0A8M6Z968
uniprot id: A0A8M6Z9L7
uniprot id: A0A8M6Z9M0
uniprot id: A0A8M9PY17
uniprot id: A0A8M9PY23
uniprot id: A0A8M9Q9V0
uniprot id: A0A8M9QFI6
uniprot id: A0A8M9QJS7
uniprot id: A0A8M9QNH1
uniprot id: A0A8M9QNH5
uniprot id: B7ZC96
uniprot id: F1QYL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Membrane

7955:mtmr1b
gene id: 7955:mtmr1b
uniprot id: A0A0R4IMW4
uniprot id: A0A8M2B8B9
uniprot id: Q58EE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

7955:znf706
gene id: 7955:znf706
uniprot id: Q6TGY0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:chac1
gene id: 7955:chac1
uniprot id: A4QNY6
uniprot id: Q5SPB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
messages: cytosol
messages: trans-Golgi network

7955:dixdc1a
gene id: 7955:dixdc1a
uniprot id: Q804T6
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DIXDC1 family.
messages: Cytoplasm
messages: Expressed throughout the embryo including the shield. Strongly expressed in notochord and head regions from the bud to somite stages. Expressed in early born neurons in the telencephalic nucleus, the nuclei of the tract of the post-optic commissure and of the medial longitudinal fasciculus, and in segmental clusters of neurons in the hindbrain.
messages: Functions as a positive effector of the Wnt signaling pathway regulating antero-posterior neural patterning.
messages: Homomers. Interacts with dishevelled and axin1.
messages: The DIX domain mediates self-interaction and interaction with dishevelled and axin1.
messages: focal adhesion

7955:cdh5
gene id: 7955:cdh5
uniprot id: Q68SP4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Membrane

7955:usp46
gene id: 7955:usp46
uniprot id: A5WWB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
messages: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity (By similarity).
messages: Interacts with WDR48.

7955:usp45
gene id: 7955:usp45
uniprot id: E9QG68
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase C19 family.
messages: Catalyzes the deubiquitination of SPDL1 (By similarity). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (By similarity). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (PubMed:27613029).
messages: Cytoplasm
messages: Morpholino-treated larvae show a reduction in eye size and significantly fewers green cone photoreceptors compared to the wild-type (PubMed:30573563). Moderate to severe eye morphological defects, with a defective formation of the retinal structures (PubMed:27613029).
messages: Nucleus
messages: Photoreceptor inner segment
messages: Retina.

7955:cacna2d1a
gene id: 7955:cacna2d1a
uniprot id: A0A8M2BBW2
uniprot id: A0A8M3ARM5
uniprot id: A0A8M3AYS1
uniprot id: A0A8M3B1Q6
uniprot id: A0A8M3B8Y7
uniprot id: A0A8N1YYV6
uniprot id: E7F4T2
uniprot id: Q5TZ68
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

7955:zgc:136971
gene id: 7955:zgc:136971
uniprot id: A0A8M6YZU9
uniprot id: A9C3Q8
uniprot id: Q1RLP3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.

7955:COX1
gene id: 7955:COX1
uniprot id: A0A0A0VG02
uniprot id: Q9MIY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity). As a newly synthesized protein, rapidly incorporates into a multi-subunit assembly intermediate in the inner membrane, called MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase) complex, whose core components are COA3/MITRAC12 and COX14. Within the MITRAC complex, interacts with COA3 and with SMIM20/MITRAC7; the interaction with SMIM20 stabilizes the newly synthesized MT-CO1 and prevents its premature turnover. Interacts with TMEM177 in a COX20-dependent manner (By similarity).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

7955:tmem120b
gene id: 7955:tmem120b
uniprot id: A0A8M1NA77
uniprot id: G1K2N4
uniprot id: Q1LY80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Necessary for efficient adipogenesis. Does not show ion channel activity.
messages: Nucleus inner membrane

7955:si:ch1073-155h21.1
gene id: 7955:si:ch1073-155h21.1
uniprot id: A0A8M1NVM1
uniprot id: F1QPB6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:runx2a
gene id: 7955:runx2a
uniprot id: Q6U1J2
names: Subcellular Location Annotation
messages: Nucleus

7955:tmem41aa
gene id: 7955:tmem41aa
uniprot id: Q502G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

7955:tmem201
gene id: 7955:tmem201
uniprot id: A0A8M3ANM6
uniprot id: A0A8M3B645
uniprot id: A4IG66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: May be involved in actin-dependent nuclear movement. May be involved in the organization of the nuclear envelope. May recruit Ran GTPase to the nuclear periphery.
messages: Membrane
messages: Nucleus inner membrane

7955:thap11
gene id: 7955:thap11
uniprot id: Q6TGZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP11 family.
messages: Nucleus
messages: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).

7955:colgalt1
gene id: 7955:colgalt1
uniprot id: A0A8N7T6E0
uniprot id: X1WCE6
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

7955:si:ch211-253h3.1
gene id: 7955:si:ch211-253h3.1
uniprot id: A0A8M1RSL2
uniprot id: A0A8M2BJA8
uniprot id: A0A8M2BJC9
uniprot id: A0A8M6YYK4
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

7955:si:ch73-234b20.5
gene id: 7955:si:ch73-234b20.5
uniprot id: A0A140LH10
uniprot id: A0A8M1P6T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

7955:ttyh1
gene id: 7955:ttyh1
uniprot id: A0A8M9P885
uniprot id: A0A8M9PDI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

7955:rock2a
gene id: 7955:rock2a
uniprot id: Q90Y37
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Homodimer.
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
messages: centrosome

7955:rab14
gene id: 7955:rab14
uniprot id: A8E577
uniprot id: Q7ZVX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

7955:c1galt1b
gene id: 7955:c1galt1b
uniprot id: Q7SYI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Homodimer; disulfide-linked.
messages: Membrane

7955:mmp14b
gene id: 7955:mmp14b
uniprot id: A0A8M2BIQ9
uniprot id: B0R0I1
uniprot id: Q7T2J1
names: Similarity
messages: Belongs to the peptidase M10A family.

7955:strip2
gene id: 7955:strip2
uniprot id: A0A8M3AR59
uniprot id: A0A8M9PI62
uniprot id: A0A8M9PVH8
uniprot id: E7F9X6
names: Similarity
messages: Belongs to the STRIP family.

7955:stc2b
gene id: 7955:stc2b
uniprot id: A0A0R4IS34
uniprot id: A0A8M2BHP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.
messages: Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.

7955:kcna6a
gene id: 7955:kcna6a
uniprot id: B3DI29
names: Subcellular Location Annotation
messages: Membrane

7955:ap5m1
gene id: 7955:ap5m1
uniprot id: A0A8M2B5U6
uniprot id: Q502J2
names: Subcellular Location Annotation
names: Subunit
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

7955:pbrm1
gene id: 7955:pbrm1
uniprot id: A0A8M3B6P7
uniprot id: A0A8M9QLS6
uniprot id: E7F8D8
names: Subcellular Location Annotation
messages: Nucleus

7955:crema
gene id: 7955:crema
uniprot id: A0A8M2BIS5
uniprot id: A0A8N7T6W6
uniprot id: E7F9I0
names: Subcellular Location Annotation
messages: Nucleus

7955:elk1
gene id: 7955:elk1
uniprot id: A0A8N7UV82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:LOC101883850
gene id: 7955:LOC101883850
uniprot id: A0A8M2BJ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

7955:terfa
gene id: 7955:terfa
uniprot id: A0A8M9QAZ0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus

7955:rgs7bpa
gene id: 7955:rgs7bpa
uniprot id: B2GRF5
uniprot id: Q08BU8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RGS7BP/RGS9BP family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: Palmitoylated. Undergoes rapid palmitoylation turnover. Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon depalmitoylation, it is targeted from the plasma membrane into the nucleus. GPCR signaling inhibits depalmitoylation and promotes localization to the plasma membrane.
messages: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling (By similarity).

7955:hephl1b
gene id: 7955:hephl1b
uniprot id: A0A8M9QCU6
names: Similarity
messages: Belongs to the multicopper oxidase family.

7955:ctu1
gene id: 7955:ctu1
uniprot id: A0A8M2BJT0
uniprot id: A0A8M6Z811
uniprot id: B2GNZ1
uniprot id: Q803X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Belongs to the glycosyltransferase 10 family.
messages: Cytoplasm
messages: Golgi stack membrane
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.

7955:napgb
gene id: 7955:napgb
uniprot id: Q6DGJ7
names: Similarity
messages: Belongs to the SNAP family.

7955:taar14b
gene id: 7955:taar14b
uniprot id: A0A8M1NDF3
uniprot id: Q5RG91
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:sec24d
gene id: 7955:sec24d
uniprot id: A0A8M9Q7U8
uniprot id: D5LMH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

7955:tgm1l5
gene id: 7955:tgm1l5
uniprot id: A0A8M3ANY3
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

7955:ucp2
gene id: 7955:ucp2
uniprot id: A0A8M3B6H4
uniprot id: Q6P0I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:cfap43
gene id: 7955:cfap43
uniprot id: A0A8N7TBN9
names: Similarity
messages: Belongs to the CFAP43 family.

7955:tmem173
gene id: 7955:tmem173
uniprot id: E7F4N7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:23091644). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed:23091644). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (By similarity). Upon binding of c-di-GMP or cGAMP, STING1 oligomerizes and is able to activate both NF-kappa-B and irf3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state (PubMed:30842662). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed:30842662). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). The ERGIC serves as the membrane source for LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome. The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation. Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (By similarity).
messages: Golgi apparatus membrane
messages: Homodimer; forms a homodimer in absence of cyclic nucleotide (c-di-GMP or cGAMP) (By similarity). Homotetramer; in presence of cyclic nucleotide (c-di-GMP or cGAMP), forms tetramers and higher-order oligomers through side-by-side packing (By similarity). Interacts (when phosphorylated) with irf3; following activation and phosphorylation by tbk1, recruits irf3 (By similarity).
messages: In absence of cGAMP, the transmembrane and cytoplasmic regions interact to form an integrated, domain-swapped dimeric assembly (By similarity). In absence of cyclic nucleotide (c-di-GMP or cGAMP), the protein is autoinhibited by an intramolecular interaction between the cyclic dinucleotide-binding domain (CBD) and the C-terminal tail (CTT) (By similarity). Following cGAMP-binding, the cyclic dinucleotide-binding domain (CBD) is closed, leading to a 180 degrees rotation of the CBD domain relative to the transmembrane domain. This rotation is coupled to a conformational change in a loop on the side of the CBD dimer, which leads to the formation of the STING1 tetramer and higher-order oligomers through side-by-side packing (By similarity). The N-terminal part of the CBD region was initially though to contain a fifth transmembrane region (TM5) but is part of the folded, soluble CBD (By similarity).
messages: Phosphorylation by TBK1 leads to activation and production of IFN-beta. Following cyclic nucleotide (c-di-GMP or cGAMP)-binding, activation and translocation from the endoplasmic reticulum, STING1 is phosphorylated by tbk1, leading to recruitment of the transcription factor irf3 to induce type-I interferons and other cytokines.
messages: The N-terminal domain interacts with glycerophospholipids and phospholipids.
messages: autophagosome membrane
messages: perinuclear region

7955:zfyve16
gene id: 7955:zfyve16
uniprot id: A0A8M1QLB2
uniprot id: E7F6D8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

7955:si:ch211-57h10.1
gene id: 7955:si:ch211-57h10.1
uniprot id: A0A8M9Q3E8
uniprot id: A2AVJ0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

7955:mdh1aa
gene id: 7955:mdh1aa
uniprot id: A0A2R9YJL1
uniprot id: A0A8M1P7P1
uniprot id: A0A8M1P861
uniprot id: Q7T3D9
uniprot id: Q801E6
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

7955:LOC108191520
gene id: 7955:LOC108191520
uniprot id: A0A8M6Z8Y1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:tprb
gene id: 7955:tprb
uniprot id: A0A8M1N766
uniprot id: A0A8M3ATA7
uniprot id: Q5RI09
names: Similarity
messages: Belongs to the TPR family.

7955:LOC100537633
gene id: 7955:LOC100537633
uniprot id: A0A8M9PI15
uniprot id: A0A8M9PTJ7
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

7955:tax1bp1b
gene id: 7955:tax1bp1b
uniprot id: Q6P132
names: Domain
names: Function
names: Tissue Specificity
messages: Expressed at relatively high levels in both proximal and distal regions of the fin bud during pectoral fin development.
messages: May have anti-apoptotic activity.
messages: The C-terminal UBZ-type zinc fingers function as ubiquitin-binding domains.

7955:grin1b
gene id: 7955:grin1b
uniprot id: A0A8M1NPN1
uniprot id: A0A8M2BJ28
uniprot id: A0A8M2BJ41
uniprot id: Q6ZM67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:si:ch211-160o17.2
gene id: 7955:si:ch211-160o17.2
uniprot id: A0A8N7TAF6
uniprot id: E7F3N0
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

7955:si:dkey-23a13.17
gene id: 7955:si:dkey-23a13.17
uniprot id: A0A140LH24
uniprot id: A0A8N7URG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:ackr3a
gene id: 7955:ackr3a
uniprot id: A0A2R8PYR8
uniprot id: A0A8M1NR73
uniprot id: A0A8M2BEZ8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:pcca
gene id: 7955:pcca
uniprot id: Q6DGE2
names: Subcellular Location Annotation
messages: Mitochondrion matrix

7955:ccka
gene id: 7955:ccka
uniprot id: A0A8M1PZY2
uniprot id: E9QEB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

7955:wnt5b
gene id: 7955:wnt5b
uniprot id: A0A8M6Z5V6
uniprot id: B3DI33
uniprot id: Q92050
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Expressed both maternally and zygotically (Ref.1). Expressed in the germ ring at the blastoderm margin during the shield stage of gastrulation, expression is higher dorsally than ventrally (PubMed:22406073). Expressed at the posterior dorsal midline at the four-somite stage and in the pectoral fin bud 48 hours post-fertilization (PubMed:22406073). Zygotic expression begins during somitogenesis and is confined to the mesenchyme of the developing tailbud, the posterior 4-5 somites and the ventrolateral mesenchyme of the head (Ref.1). In later stages, expressed in the pharyngeal arch mesenchyme and pectoral finbuds (Ref.1). Not detected in mature chondrocytes (Ref.1).
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. Regulates convergent extension movements and hypaxial myogenesis during gastrulation via activation of non-canonical Wnt signaling (PubMed:22406073).
messages: Morpholino knockdown results in convergent extension movement defects during gastrulation and an absence of myod1 expression in the majority of hypaxial muscle precursor cells.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

7955:cavin4b
gene id: 7955:cavin4b
uniprot id: Q5PQY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

7955:stard3nl
gene id: 7955:stard3nl
uniprot id: Q6DI38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

7955:gabrr3a
gene id: 7955:gabrr3a
uniprot id: B3DIE5
uniprot id: B3DIE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:LOC110440191
gene id: 7955:LOC110440191
uniprot id: A0A8M9PYZ8
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

7955:agpat3
gene id: 7955:agpat3
uniprot id: B8A4Q3
uniprot id: Q7ZWC9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

7955:zgc:103670
gene id: 7955:zgc:103670
uniprot id: A0A8M1N222
uniprot id: A0A8M2BE76
uniprot id: A0A8M2BEB6
uniprot id: F1RAK1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:olfml2bb
gene id: 7955:olfml2bb
uniprot id: A0A8M2BAU7
uniprot id: A0A8N7UVJ6
uniprot id: F1R9Q1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:traf4b
gene id: 7955:traf4b
uniprot id: B2GT41
uniprot id: Q7T1K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

7955:si:ch211-254n4.3
gene id: 7955:si:ch211-254n4.3
uniprot id: A0A8M1NL22
uniprot id: B0R1F7
names: Similarity
messages: Belongs to the TAFA family.

7955:ephx5
gene id: 7955:ephx5
uniprot id: A0A8M2BK97
uniprot id: A0A8M9QAE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

7955:junbb
gene id: 7955:junbb
uniprot id: Q7T3E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

7955:rtn1a
gene id: 7955:rtn1a
uniprot id: A0A8M1P8H2
uniprot id: F1Q8T8
uniprot id: Q4G5V1
uniprot id: Q4G5V7
uniprot id: Q6PBQ4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:lfng
gene id: 7955:lfng
uniprot id: B2GQK5
uniprot id: Q8JHF2
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A soluble form may be derived from the membrane form by proteolytic processing.
messages: Belongs to the glycosyltransferase 31 family.
messages: Expressed both maternally and throughout the zygotic stages, with highest expression at the bud stage. No evidence for a cyclic pattern of expression in the presomitic mesoderm during somitogenesis. Expressed weakly at the epiboly stage (4.5 hours) throughout the blastoderm. Expression clears from marginal region and localizes to the epiblast cells of the animal pole. As gastrulation proceeds, expressed in hypoblast cells that migrate towards the animal pole, in the prechordal plate and in forerunner cells. At 90% epiboly, expressed in the neural plate. At the three somite stage (11 hours), expressed in a small cluster of cells within the tailbud region and in future spinal cord. From the 8-14 somite stages, expressed in alternating pre-rhombomeres of the hindbrain, and more broadly in mid- and forebrain. Also expressed weakly in the anterior margins of the formed somites and in the anterior presomitic mesoderm. At the end of somitogenesis (22 hours), expressed strongly in the telencephalon and anterior midbrain, weakly in other parts of the midbrain and variably in the hindbrain.
messages: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain (PubMed:11429294, PubMed:14518000).
messages: Golgi apparatus membrane
messages: In the embryo, expressed along the A-P axis of the neural tube, within the lateral plate mesoderm, in the presomitic mesoderm and the somites, in specific rhombomeres of the hindbrain (even-numbered rhombomeres) and in the otic vesicles.
messages: Membrane

7955:atpaf1
gene id: 7955:atpaf1
uniprot id: A0A8M9PRS4
uniprot id: Q1L987
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: May play an essential role for the assembly of the mitochondrial F1-F0 complex.
messages: Mitochondrion

7955:dpep1
gene id: 7955:dpep1
uniprot id: A0A8M1P2W9
uniprot id: F1QFU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
messages: Membrane

7955:LOC108181393
gene id: 7955:LOC108181393
uniprot id: A0A8M9PFT0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:grhpra
gene id: 7955:grhpra
uniprot id: Q504F9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

7955:entpd2a.2
gene id: 7955:entpd2a.2
uniprot id: A0A8N7UUT2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7955:bmpr1ba
gene id: 7955:bmpr1ba
uniprot id: A0A8M9PJN6
uniprot id: Q9W629
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:LOC108190761
gene id: 7955:LOC108190761
uniprot id: A0A8M9Q7U7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:si:ch211-218m3.13
gene id: 7955:si:ch211-218m3.13
uniprot id: A0A8M6Z3B0
uniprot id: E7FBP1
names: Subcellular Location Annotation
messages: Membrane

7955:stat6
gene id: 7955:stat6
uniprot id: B3DGV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

7955:sema4f
gene id: 7955:sema4f
uniprot id: A0A8M2BE08
uniprot id: A0A8N7T6E4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC795715
gene id: 7955:LOC795715
uniprot id: A0A8M9PRR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

7955:ddx47
gene id: 7955:ddx47
uniprot id: Q502B4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

7955:kpna3
gene id: 7955:kpna3
uniprot id: Q8JFT7
names: Similarity
messages: Belongs to the importin alpha family.

7955:zmp:0000001114
gene id: 7955:zmp:0000001114
uniprot id: A0A8N7USU9
uniprot id: H9GXL1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:slc40a1
gene id: 7955:slc40a1
uniprot id: Q9I9R3
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Expressed in the yolk sac and placenta.
messages: May be involved in iron export and also in transfer of iron between maternal and fetal circulation.
messages: Membrane

7955:gbp1
gene id: 7955:gbp1
uniprot id: Q6DHP7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:ptdss1a
gene id: 7955:ptdss1a
uniprot id: Q803C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
messages: Endoplasmic reticulum membrane

7955:iars2
gene id: 7955:iars2
uniprot id: A0A8M1NS03
uniprot id: A0A8M9P8Q4
uniprot id: F1QUQ0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:cacng3a
gene id: 7955:cacng3a
uniprot id: A0A8M9Q7Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

7955:lcn15
gene id: 7955:lcn15
uniprot id: A0A8M2BJD4
uniprot id: Q0P3U6
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

7955:taar14l
gene id: 7955:taar14l
uniprot id: A0A8M1NDS3
uniprot id: Q5RFY5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:brinp3b
gene id: 7955:brinp3b
uniprot id: A0A8M9PJM5
uniprot id: F1Q6C6
names: Similarity
messages: Belongs to the BRINP family.

7955:LOC110439322
gene id: 7955:LOC110439322
uniprot id: A0A8M9PZX5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:oafb
gene id: 7955:oafb
uniprot id: A0A8M9PLI1
uniprot id: A0A8N7TE77
uniprot id: F1RCY0
names: Similarity
messages: Belongs to the OAF family.

7955:dock2
gene id: 7955:dock2
uniprot id: A0A8M1RM83
names: Similarity
messages: Belongs to the DOCK family.

7955:xirp2a
gene id: 7955:xirp2a
uniprot id: A0A8M2BD29
uniprot id: A0A8M3AT61
uniprot id: A0A8M9Q058
names: Domain
names: Similarity
messages: Belongs to the Xin family.
messages: Xin repeats bind F-actin.

7955:sar1b
gene id: 7955:sar1b
uniprot id: Q6PBX2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

7955:sept12
gene id: 7955:sept12
uniprot id: A0A8M3AY11
uniprot id: A0A8N7T7N9
uniprot id: E7FGH0
uniprot id: I3ISV7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

7955:hmp19
gene id: 7955:hmp19
uniprot id: A7YYG4
uniprot id: Q6P4P6
names: Similarity
messages: Belongs to the NSG family.

7955:gprc5ba
gene id: 7955:gprc5ba
uniprot id: A0A8M1P347
uniprot id: X1WEL2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:zp3b
gene id: 7955:zp3b
uniprot id: O12989
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

7955:ate1
gene id: 7955:ate1
uniprot id: A0A8M9QKC3
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

7955:si:dkey-188i13.7
gene id: 7955:si:dkey-188i13.7
uniprot id: A0A8M1P5N4
uniprot id: B8A492
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

7955:si:ch211-165e15.1
gene id: 7955:si:ch211-165e15.1
uniprot id: A0A0R4IJ71
uniprot id: A0A8M3AHS6
uniprot id: A0A8M3AQA0
uniprot id: A0A8M9NZI2
uniprot id: A0A8M9NZI6
uniprot id: A0A8M9NZI8
uniprot id: A0A8M9NZJ2
uniprot id: A0A8M9NZJ5
uniprot id: A0A8M9NZK0
uniprot id: A0A8M9P848
uniprot id: A0A8M9P852
uniprot id: A0A8M9P854
uniprot id: A0A8M9P859
uniprot id: A0A8M9P862
uniprot id: A0A8M9P867
uniprot id: A0A8M9PDC8
uniprot id: A0A8M9PDD2
uniprot id: A0A8M9PDD8
uniprot id: A0A8M9PDE5
uniprot id: A0A8M9PDE9
uniprot id: A0A8M9PDF4
uniprot id: A0A8M9PDF9
uniprot id: A0A8M9PJT1
uniprot id: A0A8M9PJT6
uniprot id: A0A8M9PJU1
uniprot id: A0A8M9PJU6
uniprot id: A0A8M9PJV2
uniprot id: A0A8M9PJV9
uniprot id: A0A8M9PMS6
uniprot id: A0A8M9PMT2
uniprot id: A0A8M9PMT8
uniprot id: A0A8M9PMU3
uniprot id: A0A8M9PMU8
names: Subcellular Location Annotation
messages: cytoskeleton

7955:pimr64
gene id: 7955:pimr64
uniprot id: A0A8M6Z465
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:LOC103911715
gene id: 7955:LOC103911715
uniprot id: A0A8M3AWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

7955:ndufs6
gene id: 7955:ndufs6
uniprot id: Q66I52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

7955:ek1
gene id: 7955:ek1
uniprot id: O13146
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylates upon activation by efna5.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Cell membrane
messages: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
messages: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation probably through activation by efna1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development (By similarity).
messages: Widely expressed in the developing zebrafish nervous system.

7955:amer2
gene id: 7955:amer2
uniprot id: F1QGH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Amer family.
messages: Cell membrane
messages: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity).

7955:adipor1a
gene id: 7955:adipor1a
uniprot id: F1QJJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

7955:cdc42ep5
gene id: 7955:cdc42ep5
uniprot id: F1R2T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

7955:pbk
gene id: 7955:pbk
uniprot id: Q6DHU8
names: Activity Regulation
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Phosphorylated; in a cell-cycle dependent manner at mitosis.

7955:slc2a2
gene id: 7955:slc2a2
uniprot id: Q102R8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:LOC101886910
gene id: 7955:LOC101886910
uniprot id: A0A8M2BFV8
names: Similarity
messages: Belongs to the cystatin family.

7955:dnd1
gene id: 7955:dnd1
uniprot id: Q7T1H5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed in the germ plasm and the primordial germ cells (PGCs). At the onset of embryogenesis, maternal product is located in granules distributed throughout the cortex of the one-cell stage embryo. At 0.5 hour post fertilization (hpf) is expressed at the vegetal part of the blastomere. At 1 hpf expressed at the distal parts of the first two cleavage furrows. At 4 hpf expressed exclusively in PGCs. Expressed in PGCs during their migration and at their arrival in the presumptive gonade. At 5 days post-fertilization (dpf) still expressed in PGCs, albeit at a lower level.
messages: Nucleus
messages: RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds to U-rich regions (URRs) in the 3'untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Germline-specific protein required for the primordial germ cell (PGC) survival and migration during early embryonic development.

7955:actr10
gene id: 7955:actr10
uniprot id: Q7ZVU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

7955:plcb3
gene id: 7955:plcb3
uniprot id: A0A0R4IVA6
uniprot id: A0A8M2BDZ4
uniprot id: A2TJ25
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

7955:si:dkey-217f16.5
gene id: 7955:si:dkey-217f16.5
uniprot id: A0A8M3B5I4
names: Subcellular Location Annotation
messages: Membrane

7955:thoc7
gene id: 7955:thoc7
uniprot id: Q6DGZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC7 family.
messages: Component of the THO subcomplex of the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
messages: Cytoplasm
messages: Nucleus
messages: Nucleus speckle
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

7955:sh3bp5b
gene id: 7955:sh3bp5b
uniprot id: Q803L6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

7955:ap3s2
gene id: 7955:ap3s2
uniprot id: Q6DGS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

7955:slc30a10
gene id: 7955:slc30a10
uniprot id: A0A0R4IEQ2
uniprot id: A0A8M3AZG9
uniprot id: A8WFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

7955:mon1bb
gene id: 7955:mon1bb
uniprot id: E7EY38
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

7955:ryr2a
gene id: 7955:ryr2a
uniprot id: A0A8M9PWM5
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:napba
gene id: 7955:napba
uniprot id: Q502J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

7955:LOC100007225
gene id: 7955:LOC100007225
uniprot id: A0A8M6YUB7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:slc41a2b
gene id: 7955:slc41a2b
uniprot id: A0A8M3ARC1
uniprot id: E7F597
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:clic4
gene id: 7955:clic4
uniprot id: Q6P0I1
uniprot id: Q7ZTT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

7955:mtmr11
gene id: 7955:mtmr11
uniprot id: E7F7E6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7955:slc25a37
gene id: 7955:slc25a37
uniprot id: B3DKD7
uniprot id: Q287T7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Highly expressed in hematopoietic organs, Expressed in the intermediate cell mass (ICM), a tissue equivalent to the mammalian extraembryonic yolk-sac blood islands. Colocalizes with gata1.
messages: Membrane
messages: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.
messages: Mitochondrion inner membrane
messages: Morpholino knockdown results in embryos which are profoundly anemic.

7955:slc12a7b
gene id: 7955:slc12a7b
uniprot id: A0A8M2B9W4
uniprot id: A0A8M2B9W9
uniprot id: A0A8M2B9Y8
uniprot id: A0A8M2BA14
uniprot id: A0A8M2BA74
uniprot id: A0A8N7TBP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

7955:asb8
gene id: 7955:asb8
uniprot id: Q7T386
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

7955:slc46a1
gene id: 7955:slc46a1
uniprot id: Q7ZWG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. SLC46A family.
messages: Cell membrane
messages: Cytoplasm
messages: Endosome membrane
messages: Monomer.
messages: Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (By similarity). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (By similarity). Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity).

7955:gorasp1a
gene id: 7955:gorasp1a
uniprot id: A0A8M2BIG8
uniprot id: Q5U3V8
names: Similarity
messages: Belongs to the GORASP family.

7955:avp
gene id: 7955:avp
uniprot id: Q8AV79
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

7955:akirin2
gene id: 7955:akirin2
uniprot id: A0A8N1TXY2
uniprot id: A5WVY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

7955:ggps1
gene id: 7955:ggps1
uniprot id: A0A0R4ILW8
uniprot id: A0A8M1P649
uniprot id: A0A8M6Z9I5
uniprot id: F1R4B6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

7955:hbegfb
gene id: 7955:hbegfb
uniprot id: A0A8M1NE67
uniprot id: A0A8M2B880
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:os9
gene id: 7955:os9
uniprot id: A0A8M2BDH0
uniprot id: Q08C06
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

7955:LOC110438201
gene id: 7955:LOC110438201
uniprot id: A0A8M9P336
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:pggt1b
gene id: 7955:pggt1b
uniprot id: Q4V8Z9
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

7955:ctnnal1
gene id: 7955:ctnnal1
uniprot id: A0A8M1NSW6
uniprot id: A0A8M9PN16
uniprot id: Q1LU92
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

7955:ugt5d1
gene id: 7955:ugt5d1
uniprot id: D3XDB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:LOC797085
gene id: 7955:LOC797085
uniprot id: A0A8M6Z1I5
uniprot id: A0A8M6Z8J3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:162171
gene id: 7955:zgc:162171
uniprot id: A3KNK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

7955:mthfs
gene id: 7955:mthfs
uniprot id: A0A0G2L0J2
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

7955:atp8b5b
gene id: 7955:atp8b5b
uniprot id: A0A0G2LAJ5
uniprot id: A0A8N7T7T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

7955:nphs2
gene id: 7955:nphs2
uniprot id: A4FVJ0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

7955:ap1b1
gene id: 7955:ap1b1
uniprot id: A0A8M1NHM4
uniprot id: A0A8M2BCC8
uniprot id: A0A8M2BCE3
uniprot id: A0A8M2BCH0
uniprot id: A0A8M3AS47
uniprot id: A0A8M3AZG4
uniprot id: A0A8M3B9I1
uniprot id: A0A8M9PKD8
uniprot id: A5PMS9
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

7955:kcnk18
gene id: 7955:kcnk18
uniprot id: D7NVC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:v2rh11
gene id: 7955:v2rh11
uniprot id: A0A8M1RHU5
uniprot id: A0A8M3B315
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:si:ch73-368j24.11
gene id: 7955:si:ch73-368j24.11
uniprot id: A0A140LFZ1
uniprot id: A0A8M2BG38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:slc25a14
gene id: 7955:slc25a14
uniprot id: A0A8M6Z2Y9
uniprot id: Q7ZVV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:rnaseh2b
gene id: 7955:rnaseh2b
uniprot id: A0A8M9QJJ8
uniprot id: Q7ZUH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

7955:fabp1a
gene id: 7955:fabp1a
uniprot id: Q1AMT3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: In adults, weakly expressed in the intestine.

7955:chst14
gene id: 7955:chst14
uniprot id: Q1RM39
uniprot id: Q805E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate.
messages: Golgi apparatus membrane
messages: Membrane

7955:cyb5a
gene id: 7955:cyb5a
uniprot id: A8WGS0
uniprot id: Q7T341
names: Similarity
messages: Belongs to the cytochrome b5 family.

7955:ankha
gene id: 7955:ankha
uniprot id: A0A8M1N7I5
uniprot id: A0A8M9PU68
uniprot id: F1Q528
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

7955:ngfb
gene id: 7955:ngfb
uniprot id: A0A8M1PAS0
uniprot id: B2GR51
uniprot id: Q6YBR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: Homodimer.
messages: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons (By similarity).
messages: Secreted

7955:jagn1a
gene id: 7955:jagn1a
uniprot id: Q5XJX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function.

7955:gpr157
gene id: 7955:gpr157
uniprot id: Q498W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 5 family.
messages: Membrane

7955:mmp20a
gene id: 7955:mmp20a
uniprot id: A0A8M6YV12
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Binds 2 calcium ions per subunit.

7955:sf3a3
gene id: 7955:sf3a3
uniprot id: Q6DRK2
names: Similarity
messages: Belongs to the SF3A3 family.

7955:ugt1b4
gene id: 7955:ugt1b4
uniprot id: D3XD65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:fgf10b
gene id: 7955:fgf10b
uniprot id: Q1XG75
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7955:taar19d
gene id: 7955:taar19d
uniprot id: A0A0R4IEE2
uniprot id: A0A8M1QLE7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:pcdh1g31
gene id: 7955:pcdh1g31
uniprot id: I6LC22
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:med13a
gene id: 7955:med13a
uniprot id: A0A8M1P4N9
uniprot id: E7FCQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7955:zdhhc8a
gene id: 7955:zdhhc8a
uniprot id: A0A8N7UUM3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:prrx1a
gene id: 7955:prrx1a
uniprot id: Q7T373
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

7955:LOC100330283
gene id: 7955:LOC100330283
uniprot id: A0A8M2BLG6
names: Subcellular Location Annotation
messages: Membrane

7955:slc39a8
gene id: 7955:slc39a8
uniprot id: A0A8M3AYZ5
names: Subcellular Location Annotation
messages: Membrane

7955:lgmn
gene id: 7955:lgmn
uniprot id: Q6NYJ7
names: Similarity
messages: Belongs to the peptidase C13 family.

7955:ptprea
gene id: 7955:ptprea
uniprot id: A0A8M1RIZ6
uniprot id: E7EZG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

7955:grm5b
gene id: 7955:grm5b
uniprot id: U3N5Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7955:picalma
gene id: 7955:picalma
uniprot id: A0A8M3AWT2
uniprot id: A0A8M3AWT7
uniprot id: A0A8M3AWV7
uniprot id: A0A8M3AWV9
uniprot id: A0A8M3B3B4
uniprot id: A0A8M3B3B6
uniprot id: A0A8M3B694
uniprot id: A0A8M3B698
uniprot id: A0A8M3BD23
uniprot id: A0A8M9PTF3
uniprot id: A0A8M9PTF8
uniprot id: A0A8M9PTG3
uniprot id: A0A8M9Q5T5
uniprot id: A0A8M9Q5T8
uniprot id: A0A8M9Q5U0
uniprot id: A0A8M9Q5U3
uniprot id: A0A8M9QBW1
uniprot id: A0A8M9QBW5
uniprot id: A0A8M9QBX0
uniprot id: A0A8M9QGF6
uniprot id: A0A8M9QGG0
uniprot id: A0A8M9QGG5
uniprot id: A0A8M9QKK5
uniprot id: A0A8M9QKL0
uniprot id: A0A8M9QKL4
uniprot id: F1QKW9
uniprot id: Q7ZVU6
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

7955:pebp4
gene id: 7955:pebp4
uniprot id: A0A8M2BII2
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

7955:ltbp1
gene id: 7955:ltbp1
uniprot id: A0A8M6YTB9
uniprot id: A0A8M6Z1R3
uniprot id: A0A8M6Z2F6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:slc4a3
gene id: 7955:slc4a3
uniprot id: A0A096X8J7
uniprot id: A0A8M3AWC1
uniprot id: A0A8M6Z7Y3
uniprot id: A0A8M9PRV8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:pofut1
gene id: 7955:pofut1
uniprot id: A0A8N7V080
uniprot id: F1R676
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

7955:atrnl1a
gene id: 7955:atrnl1a
uniprot id: A0A8M1Q138
uniprot id: F1Q4X2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:ch211-206a7.2
gene id: 7955:si:ch211-206a7.2
uniprot id: A0A1Q1NMT5
uniprot id: B4F6Q7
uniprot id: F1R4K6
names: Subcellular Location Annotation
messages: Nucleus

7955:rcan3
gene id: 7955:rcan3
uniprot id: Q5CZS1
uniprot id: Q6DG39
names: Similarity
messages: Belongs to the RCAN family.

7955:dap3
gene id: 7955:dap3
uniprot id: A5PLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

7955:jpt1a
gene id: 7955:jpt1a
uniprot id: A3KPB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

7955:spsb4a
gene id: 7955:spsb4a
uniprot id: B0S5W3
names: Similarity
messages: Belongs to the SPSB family.

7955:crygm2d1
gene id: 7955:crygm2d1
uniprot id: A0A8M1N6C0
uniprot id: B0S6M3
uniprot id: Q504G5
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:prkar1ab
gene id: 7955:prkar1ab
uniprot id: Q567D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

7955:fam124b
gene id: 7955:fam124b
uniprot id: A0A8M3APH5
uniprot id: A0A8N7T8H5
uniprot id: E7FBV6
names: Similarity
messages: Belongs to the FAM124 family.

7955:si:ch211-145b13.6
gene id: 7955:si:ch211-145b13.6
uniprot id: A0A8M3APQ8
uniprot id: E7F1B1
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:e2f3
gene id: 7955:e2f3
uniprot id: A0A8N1YZZ8
uniprot id: B8JLN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

7955:usp22
gene id: 7955:usp22
uniprot id: A0A8M9QEE8
uniprot id: A0A8M9QMM5
uniprot id: A6H8I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family.
messages: Belongs to the peptidase C19 family. UBP8 subfamily.
messages: Component of some SAGA transcription coactivator-HAT complexes.
messages: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription (By similarity).
messages: Nucleus

7955:mnat1
gene id: 7955:mnat1
uniprot id: A0A8M3BEN4
uniprot id: B8A5G8
uniprot id: Q5XJT0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

7955:paf1
gene id: 7955:paf1
uniprot id: Q4U0S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAF1 family.
messages: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in the migration of myocardial precursors to the midline and the differentiation of the atrioventricular boundary in the developing heart.
messages: Component of the PAF1 complex, which at least consists of cdc73, paf1, leo1, ctr9 and rtf1 (By similarity). The PAF1 complex interacts with PHF5A (By similarity). Interacts with ctr9 (PubMed:21338598).
messages: Nucleus

7955:trnt1
gene id: 7955:trnt1
uniprot id: F6NXI9
uniprot id: Q6IQR7
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

7955:ano9b
gene id: 7955:ano9b
uniprot id: A0A8M1QR52
uniprot id: E7F503
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

7955:nfu1
gene id: 7955:nfu1
uniprot id: A0A8M1NGP8
uniprot id: B0S8L0
names: Similarity
messages: Belongs to the NifU family.

7955:nrtn
gene id: 7955:nrtn
uniprot id: E7FAV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

7955:gnl2
gene id: 7955:gnl2
uniprot id: Q7SZQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

7955:rnf146
gene id: 7955:rnf146
uniprot id: F1R5P0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

7955:eif3g
gene id: 7955:eif3g
uniprot id: Q6DRC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

7955:asic4a
gene id: 7955:asic4a
uniprot id: Q708S4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily.
messages: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride.
messages: Cell membrane
messages: Expressed in central nervous system.
messages: First expressed at 48 hours post-fertilization (hpf). Expressed in dorsal midbrain and in retinal ganglion cells.
messages: Homotrimer or heterotrimer with other ASIC proteins.

7955:LOC110440161
gene id: 7955:LOC110440161
uniprot id: A0A8M9PXG7
names: Subcellular Location Annotation
messages: Membrane

7955:wee1
gene id: 7955:wee1
uniprot id: Q1LYE1
uniprot id: Q6DRI0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

7955:hoxb2a
gene id: 7955:hoxb2a
uniprot id: O42367
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Proboscipedia subfamily.
messages: First expressed at the 1-somite stage in the presumptive rhombomeres 3 (r3) and 5 of the developing hindbrain. By the 3- to 4-somite stages, r5 expression has increased and there is weak expression in r4 and posterior to r6. From the 10- to 20-somite stages, confined to r3, r4 and r5 with highest levels in r3 and lowest levels in r5.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Plays an important role in the patterning of hindbrain and pharyngeal arches.

7955:zgc:162239
gene id: 7955:zgc:162239
uniprot id: A3KNM3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

7955:ndufaf1
gene id: 7955:ndufaf1
uniprot id: Q5CZW0
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

7955:hey1
gene id: 7955:hey1
uniprot id: Q8AXV6
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEY family.
messages: Expressed following gastrulation. At the 1-somite stage, expressed in the paraxial mesoderm. Subsequently expressed in the telencephalon, the otic vesicles, the somites and the anterior presomitic mesoderm.
messages: Expression in the developing embryo is induced by activation of the Notch signaling pathway.
messages: Nucleus
messages: Transcriptional repressor which functions as a downstream effector of Notch signaling.

7955:gpc5a
gene id: 7955:gpc5a
uniprot id: V5NES1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

7955:pear1
gene id: 7955:pear1
uniprot id: A0A8N7T8P5
uniprot id: E7F8N2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:btg3
gene id: 7955:btg3
uniprot id: A0A2R8QIP9
uniprot id: Q5U3I9
names: Similarity
messages: Belongs to the BTG family.

7955:arcn1b
gene id: 7955:arcn1b
uniprot id: Q6DI41
uniprot id: Q7ZU89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

7955:fbn2b
gene id: 7955:fbn2b
uniprot id: A0A8M9PJN5
uniprot id: B6CS38
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:LOC100331938
gene id: 7955:LOC100331938
uniprot id: A0A0G2KN81
uniprot id: A0A8M1RN24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:elovl7a
gene id: 7955:elovl7a
uniprot id: Q7ZVN0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ndc80
gene id: 7955:ndc80
uniprot id: Q6DRJ7
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules.
messages: Artifact. Missing internal sequence that doesn't correspond to an exon-intron boundary.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which is composed of ndc80, cdca1, spbc24 and spbc25.
messages: Nucleus
messages: kinetochore

7955:tmem18
gene id: 7955:tmem18
uniprot id: Q641M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Nucleus membrane

7955:ppcs
gene id: 7955:ppcs
uniprot id: Q1JPU8
names: Similarity
messages: Belongs to the PPC synthetase family.

7955:f7i
gene id: 7955:f7i
uniprot id: Q8JHC9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:LOC556668
gene id: 7955:LOC556668
uniprot id: A0A8M3ANJ7
uniprot id: A0A8M3B6P0
uniprot id: A0A8M9P640
names: Domain
names: Similarity
messages: Belongs to the Xin family.
messages: Xin repeats bind F-actin.

7955:sin3ab
gene id: 7955:sin3ab
uniprot id: A0A8M3B4C3
uniprot id: E7F0R9
names: Subcellular Location Annotation
messages: Nucleus

7955:nckap1
gene id: 7955:nckap1
uniprot id: B0S6R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEM-1/HEM-2 family.
messages: Cell membrane
messages: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). Plays a role in neural tube closure.
messages: lamellipodium membrane

7955:nrg2a
gene id: 7955:nrg2a
uniprot id: A0A8M2B890
uniprot id: A0A8M2B897
uniprot id: A0A8M3ALK5
uniprot id: A0A8M3AMA6
uniprot id: A0A8M3ATZ5
uniprot id: A0A8M3B4T6
uniprot id: A0A8M9PCF9
uniprot id: A5D6U9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:bicc1b
gene id: 7955:bicc1b
uniprot id: A0A8N7TBW3
names: Similarity
messages: Belongs to the BicC family.

7955:si:dkey-261m9.8
gene id: 7955:si:dkey-261m9.8
uniprot id: Q4QRF4
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:LOC101882771
gene id: 7955:LOC101882771
uniprot id: A0A8M6YW69
uniprot id: A0A8M6Z2T0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:or102-2
gene id: 7955:or102-2
uniprot id: Q2PRB6
uniprot id: Q9I8Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:cax2
gene id: 7955:cax2
uniprot id: A0A8M9PHB3
uniprot id: A0A8N7TDG2
uniprot id: E7FCM1
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:85789
gene id: 7955:zgc:85789
uniprot id: Q6NWE0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

7955:memo1
gene id: 7955:memo1
uniprot id: Q803S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MEMO1 family.
messages: Interacts with ERBB2.
messages: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling (By similarity).

7955:osbpl5
gene id: 7955:osbpl5
uniprot id: A0A8M1Q2A2
uniprot id: A0A8M2BI21
uniprot id: E7FGK0
names: Similarity
messages: Belongs to the OSBP family.

7955:slc15a1b
gene id: 7955:slc15a1b
uniprot id: Q7SYE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

7955:kif16ba
gene id: 7955:kif16ba
uniprot id: A0A8M3AVN1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:mterf1
gene id: 7955:mterf1
uniprot id: A0A8M1RJ98
names: Similarity
messages: Belongs to the mTERF family.

7955:kcnh8
gene id: 7955:kcnh8
uniprot id: A0A8M6Z362
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

7955:slc1a8b
gene id: 7955:slc1a8b
uniprot id: D7RVS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

7955:scnm1
gene id: 7955:scnm1
uniprot id: Q2YDS5
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

7955:pcdh2ac
gene id: 7955:pcdh2ac
uniprot id: Q60I64
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:or114-1
gene id: 7955:or114-1
uniprot id: Q2PRE3
names: Subcellular Location Annotation
messages: Membrane

7955:ticrr
gene id: 7955:ticrr
uniprot id: Q6DRL4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the treslin family.
messages: Embryonic lethality, due to impaired S-phase progression and disruption of the S/M checkpoint, leading to premature mitotic entry and mitotic catastrophe.
messages: Interacts with topbp1 (via BRCT domains); interaction takes place in a cdk2-dependent manner (By similarity). Component of the replisome complex (By similarity).
messages: Nucleus
messages: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with topbp1 by participating in cdk2-mediated loading of cdc45l onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

7955:atp11c
gene id: 7955:atp11c
uniprot id: A0A8M3AGS1
uniprot id: A0A8M3APA8
uniprot id: A0A8M3AS49
uniprot id: A0A8M9QPH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

7955:zgc:136929
gene id: 7955:zgc:136929
uniprot id: A0A2R8QPP7
uniprot id: A0A8M2BKF4
uniprot id: Q1RLQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

7955:pfn1
gene id: 7955:pfn1
uniprot id: E7F0A1
names: Function
names: Similarity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

7955:golt1a
gene id: 7955:golt1a
uniprot id: A0A8M1PZ13
uniprot id: E7F770
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

7955:phf5a
gene id: 7955:phf5a
uniprot id: Q6YMR2
names: Similarity
messages: Belongs to the PHF5 family.

7955:kcnc1a
gene id: 7955:kcnc1a
uniprot id: A0A8M2BG67
uniprot id: A0A8M9PP12
uniprot id: B3DJD2
uniprot id: E0R7P5
uniprot id: E0R7P6
names: Subcellular Location Annotation
messages: Membrane

7955:smg9
gene id: 7955:smg9
uniprot id: A0A8M1QVH1
uniprot id: E7F7F6
names: Similarity
messages: Belongs to the SMG9 family.

7955:trappc6bl
gene id: 7955:trappc6bl
uniprot id: Q6NUY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

7955:zgc:101810
gene id: 7955:zgc:101810
uniprot id: Q5RKP7
names: Similarity
messages: Belongs to the actin family.

7955:tmprss2
gene id: 7955:tmprss2
uniprot id: Q5PRA6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:barhl1a
gene id: 7955:barhl1a
uniprot id: Q53B63
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC101884921
gene id: 7955:LOC101884921
uniprot id: A0A8M9PNG0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

7955:lss
gene id: 7955:lss
uniprot id: A4FVM4
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

7955:si:ch73-343g19.4
gene id: 7955:si:ch73-343g19.4
uniprot id: A0A0R4IB47
uniprot id: A0A8M3AQZ9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:arhgef3
gene id: 7955:arhgef3
uniprot id: A0A8M1NDE3
uniprot id: A0A8M2B8P0
uniprot id: A0A8M2B905
uniprot id: Q1MT42
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

7955:vgll2b
gene id: 7955:vgll2b
uniprot id: Q499A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

7955:ppp1r9a
gene id: 7955:ppp1r9a
uniprot id: A0A8M3ASQ4
uniprot id: A0A8M3AVP7
uniprot id: F6NTM9
names: Subcellular Location Annotation
messages: cytoskeleton

7955:zgc:153733
gene id: 7955:zgc:153733
uniprot id: Q0P3X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

7955:nf2a
gene id: 7955:nf2a
uniprot id: B3DGL5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:or124-3
gene id: 7955:or124-3
uniprot id: Q2PRM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:fam213ab
gene id: 7955:fam213ab
uniprot id: Q08C74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

7955:zgc:85843
gene id: 7955:zgc:85843
uniprot id: A0A8M2BFR9
uniprot id: Q6NWB2
names: Subcellular Location Annotation
messages: Membrane

7955:nudt12
gene id: 7955:nudt12
uniprot id: A0A8M9Q9P3
uniprot id: Q567I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

7955:zgc:110353
gene id: 7955:zgc:110353
uniprot id: Q568E1
names: Similarity
messages: Belongs to the arrestin family.

7955:LOC100329748
gene id: 7955:LOC100329748
uniprot id: A0A8M9PEC3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:cab39l
gene id: 7955:cab39l
uniprot id: Q5U373
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

7955:si:ch211-262e15.1
gene id: 7955:si:ch211-262e15.1
uniprot id: A0A8M1QR66
uniprot id: E7FFM9
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC103911178
gene id: 7955:LOC103911178
uniprot id: A0A8M3BA79
names: Similarity
messages: Belongs to the dynein heavy chain family.

7955:vps36
gene id: 7955:vps36
uniprot id: Q7ZVK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), composed of SNF8, VPS25 and VPS36.
messages: Cytoplasm
messages: Endosome

7955:palmda
gene id: 7955:palmda
uniprot id: A0A8M9P020
uniprot id: A0A8M9PNK9
uniprot id: A0A8N7TEV0
names: Similarity
messages: Belongs to the paralemmin family.

7955:taar20t
gene id: 7955:taar20t
uniprot id: A0A8M1RHH6
uniprot id: F1RCS3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:kcnh7
gene id: 7955:kcnh7
uniprot id: A0A8M2BDB0
uniprot id: A0A8M9PMI6
uniprot id: A0A8M9Q069
uniprot id: A0A8M9Q6J8
uniprot id: A0A8M9QAQ4
uniprot id: A0A8M9QFS5
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:55733
gene id: 7955:zgc:55733
uniprot id: A0A8M9PNP7
uniprot id: A0A8M9Q7N2
uniprot id: A0A8M9QBR5
uniprot id: A0A8M9QBR9
uniprot id: A0A8M9QGR2
uniprot id: Q802Y4
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

7955:zgc:136930
gene id: 7955:zgc:136930
uniprot id: A0A8M9PYS6
uniprot id: Q29R96
names: Similarity
messages: Belongs to the intermediate filament family.

7955:ttyh3b
gene id: 7955:ttyh3b
uniprot id: A0A8M2B6L0
uniprot id: Q32LT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.
messages: Probable large-conductance Ca(2+)-activated chloride channel.

7955:cdc42ep4b
gene id: 7955:cdc42ep4b
uniprot id: A0A8M1RNR2
uniprot id: E7F7G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

7955:tmed4
gene id: 7955:tmed4
uniprot id: Q6IQH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:pdgfbb
gene id: 7955:pdgfbb
uniprot id: A0A2R8Q0D8
uniprot id: A0A8M9PWR6
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:itpk1b
gene id: 7955:itpk1b
uniprot id: X1WEB0
names: Similarity
messages: Belongs to the ITPK1 family.

7955:st6galnac4
gene id: 7955:st6galnac4
uniprot id: Q0P4A3
uniprot id: Q5NDG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:fam73a
gene id: 7955:fam73a
uniprot id: A0A8M2BAM7
uniprot id: Q5XJS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitoguardin family.
messages: Homodimer and heterodimer; forms heterodimers with miga2.
messages: Mitochondrion outer membrane
messages: Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of pld6/MitoPLD dimers. May act by regulating phospholipid metabolism via pld6/MitoPLD.

7955:bnip3lb
gene id: 7955:bnip3lb
uniprot id: Q58EQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

7955:tmtc4
gene id: 7955:tmtc4
uniprot id: A4FVI1
uniprot id: B0S6W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

7955:LOC571757
gene id: 7955:LOC571757
uniprot id: A0A8M2B5C5
uniprot id: A0A8M6Z235
uniprot id: A0A8M9PND1
names: Similarity
messages: Belongs to the CUT homeobox family.

7955:spink4
gene id: 7955:spink4
uniprot id: A0A8M1P9J0
uniprot id: E7FCI0
names: Subcellular Location Annotation
messages: Secreted

7955:ints9
gene id: 7955:ints9
uniprot id: Q08BB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

7955:upp1
gene id: 7955:upp1
uniprot id: A0A8M2B4A4
uniprot id: A0A8M6YTG2
uniprot id: Q5CZW2
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

7955:cstf1
gene id: 7955:cstf1
uniprot id: F1QFK9
names: Subcellular Location Annotation
messages: Nucleus

7955:dpy19l1l
gene id: 7955:dpy19l1l
uniprot id: Q6DRN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

7955:LOC563036
gene id: 7955:LOC563036
uniprot id: A0A8M1QUM8
names: Similarity
messages: Belongs to the MHC class I family.

7955:ano8b
gene id: 7955:ano8b
uniprot id: A0A8M6Z142
uniprot id: A0A8N7UT44
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:cnnm1
gene id: 7955:cnnm1
uniprot id: A0A0G2KKC2
uniprot id: A0A8M1P517
uniprot id: A0A8M9QFF4
uniprot id: A0A8M9QJQ2
uniprot id: A0A8M9QNF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

7955:tfap2d
gene id: 7955:tfap2d
uniprot id: A0A8M2B7U2
uniprot id: Q5RJ20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP-2 family.
messages: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).
messages: Nucleus
messages: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions (By similarity).

7955:ntng2a
gene id: 7955:ntng2a
uniprot id: A0A8M3BBM3
uniprot id: A0A8M9Q3R4
uniprot id: A0A8N7USZ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ykt6
gene id: 7955:ykt6
uniprot id: B2GTI5
uniprot id: Q7ZUN8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Farnesylation is required for Golgi targeting.
messages: Golgi apparatus membrane
messages: Membrane
messages: Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting.
messages: The longin domain regulates palmitoylation and membrane targeting.
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.
messages: cytosol

7955:cnih2
gene id: 7955:cnih2
uniprot id: A0A8M9QGM1
uniprot id: Q5BL21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs).

7955:pym1
gene id: 7955:pym1
uniprot id: Q6PH11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex (By similarity).
messages: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions (By similarity).
messages: nucleolus
messages: nucleoplasm

7955:spsb1
gene id: 7955:spsb1
uniprot id: Q4V8W1
names: Similarity
messages: Belongs to the SPSB family.

7955:ptch2
gene id: 7955:ptch2
uniprot id: A0A8M1P6L9
uniprot id: F1Q8S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

7955:ttk
gene id: 7955:ttk
uniprot id: Q8AYG3
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Barely detectable in adult somatic tissues. Expressed in immature germ cells that have not completed meiosis. In ovary, expressed predominantly in previtellogenic oocytes. In testis, expressed in primary and secondary spermatocytes, but not mature spermatozoa.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Mutants show anomalies in the chromosome number of male germ cells, leading to aneuploidy and severe developmental defects in their progeny.
messages: Phosphorylates proteins on serine, threonine, and tyrosine (By similarity). Involved in mitotic cell cycle checkpoint control. Required for fin and heart regeneration. Required to prevent chromosome segregation errors during meiosis.
messages: Strongly induced in a subpopulation of cells in the proximal blastema during regenerative outgrowth.

7955:si:ch211-281p14.2
gene id: 7955:si:ch211-281p14.2
uniprot id: A0A8M3ATS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

7955:grn2
gene id: 7955:grn2
uniprot id: Q502S6
uniprot id: Q90ZC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

7955:lipt1
gene id: 7955:lipt1
uniprot id: Q08CP2
names: Similarity
messages: Belongs to the LplA family.

7955:si:ch211-113a14.29
gene id: 7955:si:ch211-113a14.29
uniprot id: R4GE15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:samd4a
gene id: 7955:samd4a
uniprot id: A0A8M3AJP3
uniprot id: A0A8M3AU41
uniprot id: X1WG96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

7955:rpsa
gene id: 7955:rpsa
uniprot id: B2GNT1
uniprot id: Q803F6
names: Caution
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with rps21. Interacts with several laminins including at least lamb1. Interacts with mdk.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

7955:rffl
gene id: 7955:rffl
uniprot id: A0A8M2B485
uniprot id: A0A8M3ASF4
uniprot id: F1QFN6
uniprot id: Q6NX02
uniprot id: X1WG81
names: Subcellular Location Annotation
messages: Cell membrane

7955:p2ry4
gene id: 7955:p2ry4
uniprot id: A0A8M2BL13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:zic5
gene id: 7955:zic5
uniprot id: Q6VUB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

7955:snrpa1
gene id: 7955:snrpa1
uniprot id: A0A8M1N398
uniprot id: F1R300
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

7955:mxd
gene id: 7955:mxd
uniprot id: A0A8N7UVH9
uniprot id: F1QXF9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

7955:LOC799227
gene id: 7955:LOC799227
uniprot id: A0A8M1Q1S9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:csgalnact2
gene id: 7955:csgalnact2
uniprot id: A0A8M1NHC5
uniprot id: A8E7C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7955:ugt5f1
gene id: 7955:ugt5f1
uniprot id: D3XDB2
uniprot id: F1QKG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:b3gnt2l
gene id: 7955:b3gnt2l
uniprot id: A0A8M9PMP9
uniprot id: A2BIK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:itga6l
gene id: 7955:itga6l
uniprot id: A0A8M9QPM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:cdc42
gene id: 7955:cdc42
uniprot id: Q52WY2
uniprot id: Q6PFU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

7955:nacc1b
gene id: 7955:nacc1b
uniprot id: A0A0R4IHV2
uniprot id: A0A8M1QR14
names: Subcellular Location Annotation
messages: Nucleus

7955:ociad1
gene id: 7955:ociad1
uniprot id: Q6NYD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OCIAD1 family.
messages: Endosome

7955:rpl36a
gene id: 7955:rpl36a
uniprot id: P61485
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

7955:pimr82
gene id: 7955:pimr82
uniprot id: A0A8M9P2D3
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:gls2b
gene id: 7955:gls2b
uniprot id: A0A8M2BLA3
uniprot id: A4IG49
names: Similarity
messages: Belongs to the glutaminase family.

7955:rpl39
gene id: 7955:rpl39
uniprot id: Q6IMW8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

7955:abl2
gene id: 7955:abl2
uniprot id: A0A0R4IYB8
uniprot id: A0A8M1NI86
uniprot id: A0A8M2BE86
uniprot id: A0A8M2BEE2
uniprot id: A0A8M2BEX3
uniprot id: A0A8M6Z7N2
uniprot id: B0UXN7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:rps27a
gene id: 7955:rps27a
uniprot id: Q7SXA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

7955:tab2
gene id: 7955:tab2
uniprot id: Q5RFW2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (By similarity). Involved in heart development (PubMed:20493459).
messages: Membrane
messages: The RanBP2-type zinc finger (NZF) mediates binding to two consecutive 'Lys-63'-linked ubiquitins.
messages: cytosol

7955:spag9a
gene id: 7955:spag9a
uniprot id: A0A286Y9Q5
uniprot id: A0A8M1P8A1
uniprot id: A0A8M6YWT6
uniprot id: A0A8M6YYQ0
uniprot id: A0A8M9P767
uniprot id: A0A8M9PHQ1
uniprot id: A0A8M9PVX6
uniprot id: A0A8M9PZF3
uniprot id: A0A8M9PZG8
names: Similarity
messages: Belongs to the JIP scaffold family.

7955:txlna
gene id: 7955:txlna
uniprot id: A0A8M6Z298
uniprot id: A5D6U5
names: Similarity
messages: Belongs to the taxilin family.

7955:hexim1
gene id: 7955:hexim1
uniprot id: A5D8S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEXIM family.
messages: Cytoplasm
messages: Homooligomer and heterooligomer. Core component of the 7SK RNP complex.
messages: Nucleus
messages: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.

7955:pbx2
gene id: 7955:pbx2
uniprot id: A0A8M6YV86
uniprot id: Q9I9B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

7955:mrpl41
gene id: 7955:mrpl41
uniprot id: B2GSF4
uniprot id: Q502B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle (By similarity).
messages: Mitochondrion

7955:aqp7
gene id: 7955:aqp7
uniprot id: A0A8M2B7X7
uniprot id: A0A8M9P367
uniprot id: D3TZW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7955:slc12a3
gene id: 7955:slc12a3
uniprot id: A0A8M1N9Z5
uniprot id: Q1LX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

7955:crybb1l3
gene id: 7955:crybb1l3
uniprot id: A7E2I4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:si:dkey-231j24.3
gene id: 7955:si:dkey-231j24.3
uniprot id: A0A8M1PSK9
names: Similarity
messages: Belongs to the Amer family.

7955:creb5b
gene id: 7955:creb5b
uniprot id: A0A8M9NZN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

7955:LOC103911004
gene id: 7955:LOC103911004
uniprot id: A0A8M3ARS8
names: Similarity
messages: Belongs to the MS4A family.

7955:afg1la
gene id: 7955:afg1la
uniprot id: A0A8M1NXE9
uniprot id: A0A8M2B5H1
uniprot id: A0A8M9PNT3
uniprot id: E7FG72
uniprot id: X1WDT8
names: Similarity
messages: Belongs to the AFG1 ATPase family.

7955:kcnj1a.2
gene id: 7955:kcnj1a.2
uniprot id: Q1L8I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:kalrna
gene id: 7955:kalrna
uniprot id: A0A8M3AVQ1
uniprot id: A0A8M3B2F5
uniprot id: A0A8M3B5D5
uniprot id: A0A8M3BC94
uniprot id: A0A8M6Z2L7
uniprot id: A0A8M9QFR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm

7955:ltbp3
gene id: 7955:ltbp3
uniprot id: A0A8M2BCL4
uniprot id: A0A8M2BCQ0
uniprot id: A0A8N7XJF8
uniprot id: F1QFX6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:fam160b1
gene id: 7955:fam160b1
uniprot id: A0A8M1P8W5
uniprot id: B8A6I4
names: Similarity
messages: Belongs to the FHIP family.

7955:qsox2
gene id: 7955:qsox2
uniprot id: A0A8M3ASX7
uniprot id: F1QJL3
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

7955:pik3c2a
gene id: 7955:pik3c2a
uniprot id: A0A8M9P1D7
uniprot id: A0A8M9PQU0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:kcnj3b
gene id: 7955:kcnj3b
uniprot id: A0A8M2BD55
uniprot id: E7F1N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

7955:si:dkey-273o13.3
gene id: 7955:si:dkey-273o13.3
uniprot id: A0A8M6Z6E5
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100534937
gene id: 7955:LOC100534937
uniprot id: A0A8M3AY64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

7955:fbxo31
gene id: 7955:fbxo31
uniprot id: A0A8M9P6V1
uniprot id: A0A8M9PVJ5
names: Similarity
names: Subunit
messages: Belongs to the FBXO31 family.
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

7955:mtfr1l
gene id: 7955:mtfr1l
uniprot id: Q7T3E8
names: Similarity
messages: Belongs to the MTFR1 family.

7955:kcnj10a
gene id: 7955:kcnj10a
uniprot id: A0A8M1RNH1
uniprot id: E7FD27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:gstm.1
gene id: 7955:gstm.1
uniprot id: Q6PFJ6
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

7955:tcirg1b
gene id: 7955:tcirg1b
uniprot id: Q7ZVM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

7955:LOC100535674
gene id: 7955:LOC100535674
uniprot id: A0A8M9P953
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:cdc34a
gene id: 7955:cdc34a
uniprot id: B2GRD7
uniprot id: Q803V7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:atp2a1
gene id: 7955:atp2a1
uniprot id: Q642Z0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:nipsnap1
gene id: 7955:nipsnap1
uniprot id: A0A8N1TSJ0
uniprot id: F6NVH9
names: Similarity
messages: Belongs to the NipSnap family.

7955:epdl1
gene id: 7955:epdl1
uniprot id: A0A8M1P0S8
uniprot id: F1RA32
names: Similarity
messages: Belongs to the ependymin family.

7955:znf687a
gene id: 7955:znf687a
uniprot id: A0A0R4IYX6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Highly expressed in the initial stages of development (4-cell up to 1k-2k cell stages). Expression slightly increases again between 24 hours and 5 dpf and after 20 dpf. Up-regulated during regeneration of the caudal fin after amputation.
messages: May be involved in transcriptional regulation.
messages: Nucleus
messages: Widely expressed with highest levels in kidney, spleen and ovary.

7955:nkx6.1
gene id: 7955:nkx6.1
uniprot id: Q6DGK5
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC103911265
gene id: 7955:LOC103911265
uniprot id: A0A8M3B3M3
uniprot id: A0A8M6YYY2
names: Similarity
messages: Belongs to the MAP7 family.

7955:en1b
gene id: 7955:en1b
uniprot id: A0A8M3B3Y5
uniprot id: Q5BJ08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

7955:cenpa
gene id: 7955:cenpa
uniprot id: Q803H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. CENPA modulates the DNA-binding characteristics of nucleosomes so that protruding DNA ends have higher flexibility than in nucleosomes containing conventional histone H3.
messages: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.
messages: Nucleus
messages: centromere

7955:trmo
gene id: 7955:trmo
uniprot id: A0A8M1N877
uniprot id: A0A8M1P8Z4
uniprot id: F1Q8W7
uniprot id: R4GEK9
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

7955:cyfip1
gene id: 7955:cyfip1
uniprot id: Q90YM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: Cytoplasm
messages: Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity).
messages: lamellipodium
messages: perinuclear region
messages: ruffle
messages: synaptosome

7955:ba1l
gene id: 7955:ba1l
uniprot id: B3DG37
uniprot id: Q90486
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from gills to the various peripheral tissues.
messages: Red blood cells.

7955:slc25a15a
gene id: 7955:slc25a15a
uniprot id: A1L288
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:got2b
gene id: 7955:got2b
uniprot id: Q7ZWF5
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

7955:enpp2
gene id: 7955:enpp2
uniprot id: A0A8M3AIW9
uniprot id: Q6PGY9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

7955:slc25a38a
gene id: 7955:slc25a38a
uniprot id: Q08CI8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At 24 hours post-fertilization, expressed predominantly in posterior blood island, posterior cardinal vein and circulating blood, as well as in somites, brain and retina. At 34 hours post-fertilization, becomes restricted to posterior blood island and circulating blood.
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Fishes lacking both slc25a38a and slc25a38b display anemia.
messages: May play a role as pro-apoptotic protein that induces caspase-dependent apoptosis.
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane

7955:mkrn1
gene id: 7955:mkrn1
uniprot id: Q4VBT5
names: Function
names: Sequence Caution
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Possible contaminating sequence. The N-terminal 7 residues do not match the underlying genomic sequence.

7955:tns2b
gene id: 7955:tns2b
uniprot id: A0A8M2BDF7
uniprot id: A0A8N7UT94
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

7955:rab3ip
gene id: 7955:rab3ip
uniprot id: Q503R3
names: Similarity
messages: Belongs to the SEC2 family.

7955:rdh20
gene id: 7955:rdh20
uniprot id: A0A8N7UVK4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:LOC100330838
gene id: 7955:LOC100330838
uniprot id: A0A8M1RHX6
names: Subcellular Location Annotation
messages: Nucleus

7955:mtx2
gene id: 7955:mtx2
uniprot id: Q6WFZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:slc8a2a
gene id: 7955:slc8a2a
uniprot id: A0A286Y8H6
uniprot id: A0A8M3ASJ4
uniprot id: A0A8M3ASJ9
uniprot id: A0A8M3ASN9
uniprot id: A0A8M3AZU6
uniprot id: A0A8M3B2Q3
uniprot id: A0A8M3B9T8
uniprot id: A0A8M3B9U2
uniprot id: B2CZC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

7955:lrrc8c
gene id: 7955:lrrc8c
uniprot id: A0A8M1P936
uniprot id: E7F333
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

7955:LOC100535713
gene id: 7955:LOC100535713
uniprot id: A0A8M9QFL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

7955:cited4a
gene id: 7955:cited4a
uniprot id: Q08CF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

7955:jakmip3
gene id: 7955:jakmip3
uniprot id: A0A8M9Q978
names: Similarity
messages: Belongs to the JAKMIP family.

7955:nmt2
gene id: 7955:nmt2
uniprot id: A7YT82
uniprot id: H2ZRH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins.
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.
messages: Cytoplasm
messages: Membrane

7955:stambpa
gene id: 7955:stambpa
uniprot id: Q6TH47
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the peptidase M67C family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: The JAMM motif is essential for the protease activity.
messages: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes (By similarity).

7955:si:dkey-269i1.3
gene id: 7955:si:dkey-269i1.3
uniprot id: A8E588
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:irf8
gene id: 7955:irf8
uniprot id: Q6DHK7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:evx1
gene id: 7955:evx1
uniprot id: A0A0R4IVI8
uniprot id: A0A8M1PBM6
names: Subcellular Location Annotation
messages: Nucleus

7955:fgf19
gene id: 7955:fgf19
uniprot id: A0A0R4IN60
uniprot id: A0A8M1N428
uniprot id: A0A8M1P7M8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7955:si:ch211-57i17.1
gene id: 7955:si:ch211-57i17.1
uniprot id: A0A8M2B7T9
uniprot id: Q05AM6
names: Similarity
messages: Belongs to the zygin family.

7955:asphd1
gene id: 7955:asphd1
uniprot id: A0A8M9PGX8
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

7955:hoxc4a
gene id: 7955:hoxc4a
uniprot id: A0A8M9PWA1
uniprot id: B2GQ57
uniprot id: Q9PWM3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At the 10-somite stage, barely expressed in the paraxial mesoderm. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit within rhombomere 7.
messages: Belongs to the Antp homeobox family.
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:cyp2k19
gene id: 7955:cyp2k19
uniprot id: A0PGM0
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:romo1
gene id: 7955:romo1
uniprot id: Q6NYD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity).
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity).
messages: Mitochondrion inner membrane

7955:ap2a1
gene id: 7955:ap2a1
uniprot id: A0A8M2BB77
uniprot id: A0A8M2BBC5
uniprot id: A0A8M2BBK5
uniprot id: A0A8M3AQZ7
uniprot id: A0A8M3B121
uniprot id: A0A8M3B8D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

7955:cul1a
gene id: 7955:cul1a
uniprot id: Q6NYS3
names: Similarity
messages: Belongs to the cullin family.

7955:map3k5
gene id: 7955:map3k5
uniprot id: A0A8M1NUN7
uniprot id: A0A8M9P2K6
uniprot id: E7F2L3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

7955:LOC110437972
gene id: 7955:LOC110437972
uniprot id: A0A8M9NZK9
uniprot id: A0A8M9P876
names: Subcellular Location Annotation
messages: Membrane

7955:eda
gene id: 7955:eda
uniprot id: A0A8M9PKL3
uniprot id: A0A8M9Q921
uniprot id: A0A8M9QEC5
uniprot id: B0YIF1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:ucmab
gene id: 7955:ucmab
uniprot id: K7NRG1
uniprot id: Q6NWB6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: Proteolytically cleaved by a furin-like convertase to generate a persistent C-terminal fragment found in almost the entire cartilage matrix, and affecting osteoblast differentiation.
messages: Sulfated on tyrosine residues.
messages: extracellular matrix

7955:gins4
gene id: 7955:gins4
uniprot id: A0A2R8Q9M1
uniprot id: A0A8M1N188
uniprot id: A0A8M9QIP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

7955:si:ch211-39i2.2
gene id: 7955:si:ch211-39i2.2
uniprot id: H9LHS9
names: Similarity
messages: Belongs to the DDIT4 family.

7955:fgg
gene id: 7955:fgg
uniprot id: Q7ZVG7
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

7955:si:ch211-71m22.5
gene id: 7955:si:ch211-71m22.5
uniprot id: A0A2R8S0G3
uniprot id: A0A8N7TBA2
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7955:atp11a
gene id: 7955:atp11a
uniprot id: A0A8M9Q0D3
uniprot id: A0A8M9Q0D9
uniprot id: A0A8M9Q0F1
uniprot id: A0A8M9QAX4
uniprot id: A0A8M9QFY8
uniprot id: A0A8M9QFZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

7955:prkra
gene id: 7955:prkra
uniprot id: A0A8M2BJT9
uniprot id: B0V3F8
uniprot id: F1Q8C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 (By similarity).
messages: Belongs to the PRKRA family.
messages: Homodimer. Interacts with dicer1 and eif2ak2/pkr. Also able to interact with dsRNA (By similarity).
messages: perinuclear region

7955:zmynd10
gene id: 7955:zmynd10
uniprot id: F1QN74
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Ciliopathy phenotypes: appearance of 3 otoliths, kidney cysts and dilated kidney tubules at 2.5 days post-fertilization (dpf). Motile cilia in the kidney show disorganized cilia bundles with either severely reduced beat amplitude or paralysis. Olfactory motile cilia are nearly completely paralyzed.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Interacts with LRRC6.
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity).
messages: centriolar satellite

7955:dlx6a
gene id: 7955:dlx6a
uniprot id: Q98877
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

7955:spns3
gene id: 7955:spns3
uniprot id: A2CER7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane
messages: Sphingolipid transporter.

7955:saa
gene id: 7955:saa
uniprot id: Q642J9
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

7955:rps15
gene id: 7955:rps15
uniprot id: Q6Q421
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

7955:csgalnact1a
gene id: 7955:csgalnact1a
uniprot id: A0A8M1PU89
uniprot id: E7F6G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7955:crygm2d20
gene id: 7955:crygm2d20
uniprot id: A3KNR6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:atp5g1
gene id: 7955:atp5g1
uniprot id: Q6IQN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

7955:phactr4b
gene id: 7955:phactr4b
uniprot id: A0A8M2B4R2
uniprot id: A0A8M2B574
uniprot id: A0A8M2B587
uniprot id: A0A8M3AI89
uniprot id: A0A8M3B1T3
uniprot id: Q6PEI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Binds ppp1ca and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity).
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

7955:spon1b
gene id: 7955:spon1b
uniprot id: A0A8M2BLK8
uniprot id: F1R2Z9
uniprot id: O42114
names: Subcellular Location Annotation
messages: extracellular matrix

7955:si:rp71-1p14.7
gene id: 7955:si:rp71-1p14.7
uniprot id: A0A8M1NA87
uniprot id: A0A8M3ALI5
uniprot id: I3ITQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

7955:sema3ga
gene id: 7955:sema3ga
uniprot id: A1L5C9
uniprot id: Q5ID22
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tspan36
gene id: 7955:tspan36
uniprot id: Q6NWG0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: N-glycosylated.
messages: Plays a role in migration and segregation of pigment cells (melanophores and xanthophores). Contributes to pigment stripe patterning in the epidermis.
messages: Strongly expressed in melanophores and xanthophores. Also detected in eye, brain, heart, skin, fin, testis and ovary.

7955:ppp3r1b
gene id: 7955:ppp3r1b
uniprot id: A0A8M2B6Z6
uniprot id: Q66HZ0
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

7955:atp6v1e1b
gene id: 7955:atp6v1e1b
uniprot id: Q8JHH4
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

7955:si:dkey-6n21.13
gene id: 7955:si:dkey-6n21.13
uniprot id: A0A8M9Q8J2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:ch211-215k15.4
gene id: 7955:si:ch211-215k15.4
uniprot id: A0A8M9PN92
names: Function
names: Similarity
names: Subunit
messages: Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
messages: Belongs to the fucolectin family.
messages: Homotrimer.

7955:zeb1b
gene id: 7955:zeb1b
uniprot id: A0A8M9QE24
uniprot id: Q9DEH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
messages: Nucleus

7955:ctdspl2a
gene id: 7955:ctdspl2a
uniprot id: Q08BB5
names: Function
names: Similarity
messages: Belongs to the CTDSPL2 family.
messages: Probable phosphatase.

7955:pdgfra
gene id: 7955:pdgfra
uniprot id: Q9DE49
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (By similarity).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Golgi apparatus
messages: Highly expressed in fertilized eggs as well as in all embryonic cells up to the end of gastrulation. Spatially restricted expression started after the onset of segmentation and was mainly localized in the developing pharyngeal arches. Transient expression was also detected in Kupffer's vesicle, a teleost-specific structure, and in lateral trunk and tail regions surrounding the neural keel, as well as areas of the developing pronephros.
messages: Interacts with homodimeric pdgfa, pdgfb and pdgfc, and with heterodimers formed by pdgfa and pdgfb. Monomer in the absence of bound ligand. Interaction with dimeric pdgfa, pdgfb and/or pdgfc leads to receptor dimerization, where both pdgfra homodimers and heterodimers with pdgfrb are observed (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. Binding of pdgfa and/or pdgfb leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric pdgfa, homodimeric pdgfb, heterodimers formed by pdgfa and pdgfb or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between pdgfra and pdgfrb. Phosphorylates pik3r1, plcg1, and ptpn11. Activation of plcg1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates pik3r1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of hras and of the MAP kinases mapk1/erk2 and/or mapk3/erk1. Promotes activation of STAT family members stat1, stat3 and stat5a and/or stat5b. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity).
messages: Ubiquitinated, leading to its internalization and degradation.
messages: cilium

7955:ctsk
gene id: 7955:ctsk
uniprot id: Q568D6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Cell membrane
messages: Secreted

7955:slc25a24
gene id: 7955:slc25a24
uniprot id: A0A8M2B7K4
uniprot id: Q66L49
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix (By similarity).
messages: Membrane
messages: Mitochondrion inner membrane
messages: The N-terminal domain can bind calcium and regulates the ATP carrier activity of the transmembrane domain. The apo form of the N-terminal domain is intrinsically disordered and binds to the transmembrane domain, leading to inhibition of the ATP carrier activity. Calcium binding leads to a major conformation change and abolishes the interaction with the transmembrane domain and the inhibition of the ATP carrier activity (By similarity).

7955:tnfrsf19
gene id: 7955:tnfrsf19
uniprot id: A0A8M6YT06
uniprot id: A0A8M9QC14
uniprot id: B1N8Y3
uniprot id: Q1ECV9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:sctr
gene id: 7955:sctr
uniprot id: G8XQM4
names: Subcellular Location Annotation
messages: Membrane

7955:gpx2
gene id: 7955:gpx2
uniprot id: A0A8M1PAJ9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7955:ogn
gene id: 7955:ogn
uniprot id: Q5BLC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

7955:LOC100149647
gene id: 7955:LOC100149647
uniprot id: A0A8M9PUN2
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7955:tuba8l4
gene id: 7955:tuba8l4
uniprot id: Q7ZVI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

7955:st6galnac3
gene id: 7955:st6galnac3
uniprot id: Q704S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:LOC100331465
gene id: 7955:LOC100331465
uniprot id: A0A8M6Z0C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:htr7b
gene id: 7955:htr7b
uniprot id: A0A8M9QGY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:akirin1
gene id: 7955:akirin1
uniprot id: B0BLV7
uniprot id: Q7T377
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

7955:kpna6
gene id: 7955:kpna6
uniprot id: A0A8M1QRD2
uniprot id: E7F7U9
names: Similarity
messages: Belongs to the importin alpha family.

7955:terb2
gene id: 7955:terb2
uniprot id: Q5BJD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TERB2 family.
messages: Component of the MAJIN-TERB1-TERB2 complex.
messages: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA.

7955:qars
gene id: 7955:qars
uniprot id: Q7ZWG7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:epyc
gene id: 7955:epyc
uniprot id: A0A8M1P5N0
uniprot id: B0S5X0
uniprot id: Q5RI46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: extracellular matrix

7955:rab3gap1
gene id: 7955:rab3gap1
uniprot id: Q6NUV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of rab3gap1 and rab3gap2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (By similarity). As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (By similarity). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (By similarity). The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (By similarity). Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: The Rab3 GTPase-activating complex is a heterodimer composed of rab3gap1 and rab3gap2 (By similarity). The Rab3 GTPase-activating complex interacts with DMXL2 (By similarity). Interacts with LMAN1 (By similarity).

7955:nrm
gene id: 7955:nrm
uniprot id: Q1L911
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Nucleus inner membrane

7955:tecpr1a
gene id: 7955:tecpr1a
uniprot id: A0A8M3AYC6
uniprot id: A0A8M9Q8Y3
names: Similarity
messages: Belongs to the TECPR1 family.

7955:cavin2a
gene id: 7955:cavin2a
uniprot id: F1Q688
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

7955:yme1l1a
gene id: 7955:yme1l1a
uniprot id: A0A8M1RL79
uniprot id: A0A8M2B9Y9
uniprot id: E7EZJ5
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

7955:si:dkey-204f11.3
gene id: 7955:si:dkey-204f11.3
uniprot id: A0A8M1NCG0
uniprot id: Q5PNN0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:LOC100334219
gene id: 7955:LOC100334219
uniprot id: A0A8M6Z5N1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:snap23.1
gene id: 7955:snap23.1
uniprot id: A0A2R8RXS8
uniprot id: A0A8M2B5L7
uniprot id: A0A8M9PE44
uniprot id: Q7ZVE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

7955:ptmab
gene id: 7955:ptmab
uniprot id: A5PLC8
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the pro/parathymosin family.
messages: Expressed both maternally and zygotically. First expressed at 4 hpf. Expression is lower by 8 hpf and increases almost constantly thereafter.
messages: Nucleus
messages: Uniformly expressed in all embryonic cells at 4 and 8 hpf. At the 20-somite stage (18 hpf), ubiquitously expressed in the developing nervous system, in the tail bud and in the pronephric ducts. Also expressed in some placodes, including the anterior lateral line placode, otic vesicle and olfactory placode. At 27 hpf, strong expression persists in the central nervous system and the olfactory placode. Expressed strongly in the eyes and the pectoral fin buds. In the tail region, expressed in the spinal cord, in the posterior lateral line precursors, and persists in the pronephric ducts. At 48 hpf, expressed in all head territories including the developing brain, eyes, and pharyngeal arches. More caudally, expression persists in the pectoral fin buds, the spinal cord and, for the first time, appears in the intestine. At 72 hpf, expressed only in restricted regions of the brain, in pharyngeal arches region and in the amacrine cells and the horizontal cells of the retina.

7955:zfpl1
gene id: 7955:zfpl1
uniprot id: A0A0R4IZJ5
uniprot id: A0A8M2BFW9
uniprot id: P62447
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZFPL1 family.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

7955:cdk4
gene id: 7955:cdk4
uniprot id: Q08C29
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:dkey-28b4.8
gene id: 7955:si:dkey-28b4.8
uniprot id: F1Q7N8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:psenen
gene id: 7955:psenen
uniprot id: Q8JHF0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3D-structure analysis of the human homolog indicates that the membrane topology differs from the predictions. Contrary to predictions, the N-terminus contains two short helices that dip into the membrane, but do not cross it. The C-terminus contains the single transmembrane helix. This gives rise to a topology where the N-terminus is cytoplasmic and the C-terminus is lumenal.
messages: Belongs to the PEN-2 family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
messages: Golgi stack membrane
messages: Membrane
messages: The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (psen1 or psen2), nicastrin (ncstn), aph1 (aph1a or aph1b) and psenen.

7955:cntnap5l
gene id: 7955:cntnap5l
uniprot id: A0A8M1PUN3
uniprot id: A0A8M6Z962
uniprot id: A0A8M9Q7S5
uniprot id: A0A8M9QDQ4
uniprot id: E7EZI3
names: Caution
names: Similarity
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ttc36
gene id: 7955:ttc36
uniprot id: A8E7I5
names: Similarity
messages: Belongs to the TTC36 family.

7955:ampd2a
gene id: 7955:ampd2a
uniprot id: A0A8M1REB8
uniprot id: A0A8M3ALY9
uniprot id: A0A8M3AMN9
uniprot id: A0A8M3AUC9
uniprot id: A0A8M3AXB7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

7955:si:ch211-254p10.2
gene id: 7955:si:ch211-254p10.2
uniprot id: A0A8M9PMZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

7955:adcy1b
gene id: 7955:adcy1b
uniprot id: D1MIA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

7955:si:rp71-39b20.4
gene id: 7955:si:rp71-39b20.4
uniprot id: A0A8M2BIH5
uniprot id: F1QZV9
names: Subcellular Location Annotation
messages: Membrane

7955:pcsk6
gene id: 7955:pcsk6
uniprot id: A0A8M9QIA8
names: Similarity
messages: Belongs to the peptidase S8 family.

7955:gper1
gene id: 7955:gper1
uniprot id: B3G515
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endoplasmic reticulum membrane
messages: Expressed in brain regions that are known to control reproduction and sex behavior. Expressed in ovary, muscle and intestine. Expressed in early germ cells of the testis, including the spermatogonia, spermatocytes, and somatic cells such as Sertoli cells.
messages: Expressed throughout early embryonic development from 0 hours post-fertilization (hpf) to 72 hpf. Expressed in blastomeres at 4 hpf. Expressed in the central nervous system at 18 hpf. Expressed in head including the anterior diencephalon, midbrain and hindbrain at 24 hpf. Expressed in trigeminal ganglia as well as in the heart, pancreas and intestinal bulb between 36 and 72 hpf (at protein level).
messages: Golgi apparatus membrane
messages: Homodimer. Heterodimer (By similarity).
messages: Membrane G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in the embryonic development of sensory and motor neurons. Specifically induces apoptosis and reduces proliferation of brain cells. Involved in maintenance of meiotic arrest in oocytes.
messages: Mitochondrion membrane
messages: Morpholino knockdown of the protein leads to growth retardation and developmental deformity.
messages: Nucleus
messages: Postsynaptic density
messages: Recycling endosome
messages: axon
messages: cytoskeleton
messages: dendrite
messages: dendritic spine membrane
messages: perinuclear region
messages: trans-Golgi network

7955:cacna2d4b
gene id: 7955:cacna2d4b
uniprot id: A0A8M3AZP4
uniprot id: A0A8M9PN85
uniprot id: A0A8M9PYY9
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

7955:nop16
gene id: 7955:nop16
uniprot id: Q6DGI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

7955:slc30a2
gene id: 7955:slc30a2
uniprot id: A0A0R4IIM2
uniprot id: A0A8M3AL21
uniprot id: A0A8N7UYA1
uniprot id: F1QFA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

7955:si:dkey-85p17.3
gene id: 7955:si:dkey-85p17.3
uniprot id: A0A8M9QM00
names: Subcellular Location Annotation
messages: cytoskeleton

7955:eif3s6ip
gene id: 7955:eif3s6ip
uniprot id: Q7T2A5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

7955:ndufs8a
gene id: 7955:ndufs8a
uniprot id: Q6P0T0
uniprot id: Q6PE39
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

7955:LOC100334018
gene id: 7955:LOC100334018
uniprot id: A0A8M1RR41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

7955:slc25a51b
gene id: 7955:slc25a51b
uniprot id: A0A8M3AZL2
uniprot id: E7F6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:slc11a2
gene id: 7955:slc11a2
uniprot id: Q1RLY4
names: Similarity
messages: Belongs to the NRAMP family.

7955:slitrk6
gene id: 7955:slitrk6
uniprot id: A0A0R4IS19
uniprot id: A0A8M1P1A6
names: Similarity
messages: Belongs to the SLITRK family.

7955:cacna2d2a
gene id: 7955:cacna2d2a
uniprot id: A0A1D5NSP7
uniprot id: A0A8M1N4H3
uniprot id: A0A8M3ATR3
uniprot id: A0A8M3B0S8
uniprot id: A0A8M3BAM9
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

7955:LOC562770
gene id: 7955:LOC562770
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:mybbp1a
gene id: 7955:mybbp1a
uniprot id: A0A0R4IH55
uniprot id: A0A8M1MZS2
names: Similarity
messages: Belongs to the MYBBP1A family.

7955:yipf3
gene id: 7955:yipf3
uniprot id: B2GQM8
uniprot id: Q803Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity).
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

7955:tfec
gene id: 7955:tfec
uniprot id: A0A8M2BBP2
uniprot id: A0A8M6Z5C1
uniprot id: A0A8M9PUG4
uniprot id: Q1JQ62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

7955:slc2a11a
gene id: 7955:slc2a11a
uniprot id: A0A8M3ATK7
uniprot id: A0A8M3BAK2
uniprot id: E7FEA2
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:scube2
gene id: 7955:scube2
uniprot id: A0A0B5JWE1
uniprot id: A0A8M2BDU1
uniprot id: A0A8M2BDV7
uniprot id: A0A8M2BDX4
uniprot id: A0A8M9PNW8
uniprot id: A0A8M9QBZ2
uniprot id: Q5G872
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cell surface
messages: Expressed in the dorsal neural tube.
messages: Interacts with SHH via the cholesterol anchor of the dually lipid-modified SHH (ShhNp) (By similarity). Interacts with PTCH1 (By similarity). Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3 (By similarity). Interacts with VEGFR2 (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
messages: N-glycosylated.
messages: Secreted
messages: The CUB domain is important for the interaction with the cholesterol-anchor of SHH. The CUB domain regulates protease recruitment and activation during SHH shedding.
messages: Zebrafish 'you class' developmental mutants are grouped together based on the anormal U-shaped morphology of the somites. Homozygous zebrafish mutants show disruption of the formation of hedgehog-sensitive muscle fates, with an altered myotomal morphology from a characteristic chevron shape to a more rounded U-shaped. One of these 'you class' mutant results from disruption of the Scube2 gene. These mutants lack slow twitch muscle and muscle pionneer cells, and PTCH1 expression within the myotome and neural tube is essentially absent.

7955:sphkap
gene id: 7955:sphkap
uniprot id: Q1LV19
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).
messages: Belongs to the AKAP110 family.
messages: Cytoplasm
messages: RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

7955:calcr
gene id: 7955:calcr
uniprot id: A0A8M9PPS1
uniprot id: F1R4K2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

7955:ip6k2a
gene id: 7955:ip6k2a
uniprot id: A0A8M9QA58
uniprot id: Q6PBN6
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:rbl2
gene id: 7955:rbl2
uniprot id: A0A8M1RLB4
uniprot id: A0A8M3AZW2
uniprot id: E7FDM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

7955:nudt5
gene id: 7955:nudt5
uniprot id: Q6IQ66
names: Similarity
messages: Belongs to the Nudix hydrolase family.

7955:pkn2
gene id: 7955:pkn2
uniprot id: A0A0R4IJZ0
uniprot id: A0A8N7T8C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

7955:pes
gene id: 7955:pes
uniprot id: P79741
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the PeBoW complex, composed of bop1, pes1 and wdr12. The complex is held together by bop1, which interacts with pes1 via its N-terminal domain and with wdr12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Embryos exhibit smaller eyes, a reduced brain and visceral skeleton, shortened fins and a lack of expansion of liver and gut, and die on day 6 of development.
messages: Widely and highly expressed during the first 3 days of embryogenesis. Prominent sites of expression are the eyes and optic tectum on day 1, the fin buds, liver primordium, and gut on day 2, and the branchial arches on day 3.
messages: nucleolus
messages: nucleoplasm

7955:si:dkey-239j18.2
gene id: 7955:si:dkey-239j18.2
uniprot id: E9QBE2
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:mnx1
gene id: 7955:mnx1
uniprot id: Q6SYZ1
names: Subcellular Location Annotation
messages: Nucleus

7955:hoxa4a
gene id: 7955:hoxa4a
uniprot id: A0A8M9PB41
uniprot id: A0A8M9PNI5
uniprot id: Q9PWL5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: First expressed at the 1-somite stage. At the 10-somite stage, weakly expressed in the paraxial mesoderm with an anterior expression limit at somite 1. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit adjacent to the rhombomere 7/8 boundary.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:psmd13
gene id: 7955:psmd13
uniprot id: Q7ZU69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

7955:anapc1
gene id: 7955:anapc1
uniprot id: A0A2R8QA59
uniprot id: A0A8M1QKJ8
uniprot id: A0A8M2B392
uniprot id: A0A8M2B3F5
uniprot id: A0A8M9QG54
names: Similarity
messages: Belongs to the APC1 family.

7955:wdr75
gene id: 7955:wdr75
uniprot id: Q7ZVR1
names: Function
names: Subcellular Location Annotation
messages: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.
messages: nucleolus

7955:gsx2
gene id: 7955:gsx2
uniprot id: B2GPF8
uniprot id: Q1RMA3
names: Subcellular Location Annotation
messages: Nucleus

7955:atad1b
gene id: 7955:atad1b
uniprot id: B2GP29
uniprot id: Q503W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Belongs to the AAA ATPase family. MSP1 subfamily.
messages: Mitochondrion outer membrane
messages: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity).
messages: Peroxisome membrane
messages: Postsynaptic cell membrane

7955:mctp2b
gene id: 7955:mctp2b
uniprot id: A0A8M9Q261
uniprot id: A0A8M9Q8B7
names: Subcellular Location Annotation
messages: Membrane

7955:LOC799006
gene id: 7955:LOC799006
uniprot id: A0A8M9QP02
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:gtf2f2a
gene id: 7955:gtf2f2a
uniprot id: A0A8M1MZY4
uniprot id: A7MCQ3
uniprot id: B8JHR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

7955:zgc:173742
gene id: 7955:zgc:173742
uniprot id: A0A8M2BH93
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

7955:ttc38
gene id: 7955:ttc38
uniprot id: A0A8M2B5G9
uniprot id: A3KPN8
names: Similarity
messages: Belongs to the TTC38 family.

7955:vps25
gene id: 7955:vps25
uniprot id: A0A8M1NCW3
uniprot id: F1QSR5
names: Similarity
messages: Belongs to the VPS25 family.

7955:abcg2d
gene id: 7955:abcg2d
uniprot id: A0A8M3B3I6
uniprot id: Q2Q444
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

7955:rnf185
gene id: 7955:rnf185
uniprot id: Q6PC78
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity).
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.

7955:snx2
gene id: 7955:snx2
uniprot id: Q32LT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

7955:scrn2
gene id: 7955:scrn2
uniprot id: Q5TYS5
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

7955:cyp3c2
gene id: 7955:cyp3c2
uniprot id: A0A8M6Z545
uniprot id: A0A8M9PZM0
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:anxa2a
gene id: 7955:anxa2a
uniprot id: Q804G9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

7955:cd74a
gene id: 7955:cd74a
uniprot id: Q9PUT2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100148041
gene id: 7955:LOC100148041
uniprot id: A0A8M9PMC0
uniprot id: A0A8M9PXZ8
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

7955:srd5a1
gene id: 7955:srd5a1
uniprot id: A5PMI4
uniprot id: Q08C19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

7955:si:ch73-174h16.4
gene id: 7955:si:ch73-174h16.4
uniprot id: A0A8N7TEM8
uniprot id: E7F4Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRAME family. LRRC14 subfamily.
messages: Cytoplasm

7955:twf2
gene id: 7955:twf2
uniprot id: A0A8M2BDE1
uniprot id: Q6GMH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin (By similarity).
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: Interacts with G-actin; ADP-actin form and capping protein (CP).
messages: cytoskeleton
messages: perinuclear region

7955:stx16
gene id: 7955:stx16
uniprot id: A0A2R8Q071
uniprot id: A0A8M2BJE0
uniprot id: A0A8M9Q0Y1
uniprot id: A0A8M9QGE3
names: Similarity
messages: Belongs to the syntaxin family.

7955:gbgt1l2
gene id: 7955:gbgt1l2
uniprot id: A0A8M1NHN1
uniprot id: A0A8M2BCD3
uniprot id: A0A8M3B2C8
uniprot id: A0A8M9QE87
uniprot id: B0R0W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

7955:zic2b
gene id: 7955:zic2b
uniprot id: Q9DE40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

7955:LOC101883139
gene id: 7955:LOC101883139
uniprot id: A0A8M2BAH4
uniprot id: A0A8M3AQ89
uniprot id: A0A8M6Z1L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

7955:LOC100005420
gene id: 7955:LOC100005420
uniprot id: A0A8M9QFM2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ccl38a.3
gene id: 7955:ccl38a.3
uniprot id: A0A8M1RJD6
uniprot id: A0A8M6YWV2
uniprot id: E7F787
uniprot id: F8W4J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

7955:si:dkey-26i13.8
gene id: 7955:si:dkey-26i13.8
uniprot id: A0A8M1Q799
uniprot id: A0A8M6YYY0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:tfr2
gene id: 7955:tfr2
uniprot id: Q5MPX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

7955:chst12b
gene id: 7955:chst12b
uniprot id: A0A8M2B6G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:cbsb
gene id: 7955:cbsb
uniprot id: Q5EI65
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

7955:chia.6
gene id: 7955:chia.6
uniprot id: A0A8M1P9S1
uniprot id: F1QJL0
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7955:cpxm1b
gene id: 7955:cpxm1b
uniprot id: A0A0R4IUK4
uniprot id: A0A8M3B0L0
uniprot id: A0A8M9QL50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

7955:si:dkey-240h12.4
gene id: 7955:si:dkey-240h12.4
uniprot id: A0A8M9PBF2
uniprot id: F1QN42
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:slc6a6a
gene id: 7955:slc6a6a
uniprot id: A0A8M1NHB3
uniprot id: B0V3R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

7955:faim2a
gene id: 7955:faim2a
uniprot id: F1QZ65
uniprot id: Q5BJK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7955:fundc1
gene id: 7955:fundc1
uniprot id: Q6DH87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

7955:p4ha1a
gene id: 7955:p4ha1a
uniprot id: A0A0R4IQ20
uniprot id: E7FEB4
uniprot id: F1QCL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7955:ccdc39
gene id: 7955:ccdc39
uniprot id: A0A8M1PVA8
names: Similarity
messages: Belongs to the CCDC39 family.

7955:zgc:152658
gene id: 7955:zgc:152658
uniprot id: Q08CV6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:dok1b
gene id: 7955:dok1b
uniprot id: Q6NY95
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

7955:tbc1d23
gene id: 7955:tbc1d23
uniprot id: A0A8M2BD99
uniprot id: Q7SXV1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Detected as early as 1 hour post-fertilization (hpf). Primarily localized in the head at 48 hpf.
messages: Morpholino knockdown of the protein causes reduced brain and eye size and curved tails at 48 hpf.
messages: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development (PubMed:28823706). May act as a general inhibitor of innate immunity signaling (By similarity).
messages: trans-Golgi network

7955:kif2c
gene id: 7955:kif2c
uniprot id: A0A8M2BAP1
uniprot id: A9JRA8
uniprot id: B0S7G2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:dnaaf2
gene id: 7955:dnaaf2
uniprot id: Q499A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Dynein axonemal particle
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

7955:phospho2
gene id: 7955:phospho2
uniprot id: A9JRB9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

7955:lygl1
gene id: 7955:lygl1
uniprot id: A0A8M2BKV1
uniprot id: Q6DH80
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

7955:tnfsf11
gene id: 7955:tnfsf11
uniprot id: A0A8M1RHF9
uniprot id: E7F3U1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:sort1a
gene id: 7955:sort1a
uniprot id: Q6NUT7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS10-related sortilin family. SORT1 subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. May also mediate transport from the endoplasmic reticulum to the Golgi.
messages: Golgi stack membrane
messages: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35; which is involved in retrograde trafficking of the receptor from endosomes to the Golgi apparatus (By similarity).
messages: Lysosome membrane
messages: Nucleus membrane
messages: Palmitoylated. Undergoes cysteine S-palmitoylation which promotes the partitioning of the receptor into an endosomal membrane subdomain where it can interact with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus.

7955:si:ch73-122k23.1
gene id: 7955:si:ch73-122k23.1
uniprot id: A0A8M9PQG6
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:si:dkey-33c12.10
gene id: 7955:si:dkey-33c12.10
uniprot id: A0A8M9QK16
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:zgc:165520
gene id: 7955:zgc:165520
uniprot id: A0A8M1P6K2
uniprot id: B8A651
names: Similarity
messages: Belongs to the syntaxin family.

7955:gid8b
gene id: 7955:gid8b
uniprot id: E7FGY2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (By similarity). Required for normal Wnt signaling and normal dorsoventral patterning during embryogenesis (PubMed:28829046).
messages: Cytoplasm
messages: Expressed in the early developmental stages of embryos.
messages: Identified in the CTLH complex that contains at least MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10. Interacts with CTNNB1.
messages: Morpholino knockdown produces morphants which exhibit loss or reduction of dorsal embryonic structures and Wnt signaling deficiency.
messages: Nucleus

7955:malrd1
gene id: 7955:malrd1
uniprot id: A0A8M9Q147
uniprot id: A0A8N7XJ89
uniprot id: E7F1Z9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC101886149
gene id: 7955:LOC101886149
uniprot id: A0A8M2BFM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

7955:wu:fj81e10
gene id: 7955:wu:fj81e10
uniprot id: A0A8M9PU63
names: Similarity
messages: Belongs to the CD36 family.

7955:mmp25b
gene id: 7955:mmp25b
uniprot id: A0A8M1RM62
uniprot id: E7F1N5
names: Similarity
messages: Belongs to the peptidase M10A family.

7955:igfbp6b
gene id: 7955:igfbp6b
uniprot id: A0A8M1NRL3
uniprot id: C4MCP1
uniprot id: F6N9E8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:LOC100535067
gene id: 7955:LOC100535067
uniprot id: A0A8M1RP19
names: Similarity
messages: Belongs to the PRR15 family.

7955:pimr135
gene id: 7955:pimr135
uniprot id: A0A8M6Z0T0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:pfdn4
gene id: 7955:pfdn4
uniprot id: A0A8M1RL59
uniprot id: F1R0Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

7955:aasdh
gene id: 7955:aasdh
uniprot id: A0A0A0MPS9
uniprot id: A0A8N7TBY2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:anxa13
gene id: 7955:anxa13
uniprot id: Q6PHG3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

7955:rdh10a
gene id: 7955:rdh10a
uniprot id: A1L1W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity).

7955:cnih4
gene id: 7955:cnih4
uniprot id: A0A8N7T6U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

7955:sec22c
gene id: 7955:sec22c
uniprot id: E9QFN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

7955:tmem30aa
gene id: 7955:tmem30aa
uniprot id: A0A8M1PFN3
uniprot id: F1QEI3
uniprot id: Q6GMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: secretory vesicle membrane

7955:sgip1a
gene id: 7955:sgip1a
uniprot id: A0A8M3ATF2
uniprot id: A0A8M3ATF7
uniprot id: A0A8M3ATG9
uniprot id: A0A8M3B0I9
uniprot id: A0A8M3B3H7
uniprot id: A0A8M3B3I1
uniprot id: A0A8M3BAF6
uniprot id: A0A8M3BAG0
uniprot id: A0A8M6Z7G8
uniprot id: A0A8M9QB26
uniprot id: A0A8M9QG40
names: Subcellular Location Annotation
messages: clathrin-coated pit

7955:LOC795962
gene id: 7955:LOC795962
uniprot id: A0A8M9QHE8
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

7955:pot1
gene id: 7955:pot1
uniprot id: A0A8M2BA64
uniprot id: A0A8M9PMS4
uniprot id: A0A8M9PUZ9
uniprot id: A0A8M9PYF2
uniprot id: E7F0D5
uniprot id: F1D6H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

7955:g6pd
gene id: 7955:g6pd
uniprot id: A0A8M2B959
uniprot id: A0A8M3AY75
uniprot id: E7FDY7
uniprot id: F6NHI0
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.

7955:tac3b
gene id: 7955:tac3b
uniprot id: A0A8M2BDL5
uniprot id: H2D7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

7955:cryaba
gene id: 7955:cryaba
uniprot id: B3DFW1
uniprot id: Q9PUR2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7955:LOC100150834
gene id: 7955:LOC100150834
uniprot id: A0A8M9PMQ2
names: Subcellular Location Annotation
messages: Membrane

7955:trmt12
gene id: 7955:trmt12
uniprot id: Q0P466
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity).

7955:cx55.5
gene id: 7955:cx55.5
uniprot id: Q9DF30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:slc25a36b
gene id: 7955:slc25a36b
uniprot id: A0A8N7TCX4
uniprot id: X1WCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:gnrhr1
gene id: 7955:gnrhr1
uniprot id: A0A8M9P1N9
uniprot id: B9P4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:man1b1b
gene id: 7955:man1b1b
uniprot id: A5WWD5
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

7955:zgc:109949
gene id: 7955:zgc:109949
uniprot id: A0A0R4IY94
uniprot id: A0A8M1N650
uniprot id: A0A8M3B829
uniprot id: Q504D0
names: Similarity
messages: Belongs to the folate receptor family.

7955:irg1
gene id: 7955:irg1
uniprot id: A0A8M1NJI3
uniprot id: B0UYM1
names: Similarity
messages: Belongs to the PrpD family.

7955:LOC108179554
gene id: 7955:LOC108179554
uniprot id: A0A8M6YVC0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

7955:LOC108190369
gene id: 7955:LOC108190369
uniprot id: A0A8M9QAN9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:c19h1orf109
gene id: 7955:c19h1orf109
uniprot id: Q8JHH5
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Embryos show defects in branchial arch and ceratohyal development.
messages: Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (By similarity). Plays an essential role in early embryonic development (PubMed:12006978).
messages: Nucleus

7955:mvb12bb
gene id: 7955:mvb12bb
uniprot id: A0A8M1NIX6
uniprot id: A0A8M9QDI2
uniprot id: A0A8M9QID7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

7955:hoxd10a
gene id: 7955:hoxd10a
uniprot id: Q90469
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: First expressed at 11 hours post-fertilization (hpf) in the dorsal presomitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 9. At 24-26 hpf, posterior expression begins to weaken and is undetectable by 40-56 hpf.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:si:dkey-196h17.9
gene id: 7955:si:dkey-196h17.9
uniprot id: A0A0R4IYN9
uniprot id: A0A8M3AYV5
uniprot id: A0A8M3BEG8
names: Similarity
messages: Belongs to the SEC6 family.

7955:LOC103908824
gene id: 7955:LOC103908824
uniprot id: A0A8M9NYH7
uniprot id: A0A8M9P744
uniprot id: A0A8M9PIF9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100330229
gene id: 7955:LOC100330229
uniprot id: A0A8M9PZK9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

7955:nanos3
gene id: 7955:nanos3
uniprot id: Q90WW1
names: Similarity
messages: Belongs to the nanos family.

7955:timm23b
gene id: 7955:timm23b
uniprot id: A0A0J9YJ60
uniprot id: A0A8M1RME8
names: Subcellular Location Annotation
messages: Membrane

7955:si:dkey-33i11.4
gene id: 7955:si:dkey-33i11.4
uniprot id: C0HJJ0
uniprot id: X5IY73
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FXYD family.
messages: Cell membrane
messages: Detected in adult gill and in larval skin at 2 days post-fertilization (at protein level). In adult gill, strong expression is found in the basal regions of the secondary lamellae.
messages: Expressed from 1 day post-fertilization.
messages: Induced in larvae and adult gills by low salinity and repressed by high salinity.
messages: May modulate the activity of a sodium/potassium-transporting ATPase.
messages: Morpholino knockdown of the protein results in an increased number of sodium/potassium-transporting ATPase-expressing cells in larval skin.

7955:f2r
gene id: 7955:f2r
uniprot id: A2BIP6
uniprot id: C7EY74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:crp6
gene id: 7955:crp6
uniprot id: A3KPH6
uniprot id: B3DHF4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:cyp1b1
gene id: 7955:cyp1b1
uniprot id: B8JKD5
uniprot id: Q1JQ70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

7955:serpind1
gene id: 7955:serpind1
uniprot id: B0V3R7
uniprot id: Q8AYE2
names: Similarity
messages: Belongs to the serpin family.

7955:lnpep
gene id: 7955:lnpep
uniprot id: A0A0R4IIN9
uniprot id: A0A8M2BCR8
uniprot id: A0A8M9Q2W4
uniprot id: A0A8M9QDJ5
uniprot id: Q6PE23
names: Similarity
messages: Belongs to the peptidase M1 family.

7955:csnk1g2a
gene id: 7955:csnk1g2a
uniprot id: A0A8M2BIW9
uniprot id: Q503C4
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

7955:clasp1b
gene id: 7955:clasp1b
uniprot id: A0A8M2B4M9
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:fat1a
gene id: 7955:fat1a
uniprot id: A0A8M1PMX5
uniprot id: A0A8M2BFN2
uniprot id: A0A8M2BG88
uniprot id: A0A8M9PRG7
uniprot id: A0A8M9PV49
uniprot id: A2BGT8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:itpka
gene id: 7955:itpka
uniprot id: A0A8M1P3D6
uniprot id: F1QC01
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:inha
gene id: 7955:inha
uniprot id: A0A8M1NA81
uniprot id: Q1LYE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

7955:rnf144aa
gene id: 7955:rnf144aa
uniprot id: Q5RFV4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBR family. RNF144 subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
messages: Membrane

7955:kif22
gene id: 7955:kif22
uniprot id: A8WFU8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA.
messages: Nucleus
messages: Ubiquitinated, leading to its subsequent proteasomal degradation.
messages: cytoskeleton

7955:prkg1b
gene id: 7955:prkg1b
uniprot id: A0A2R8Q8R8
uniprot id: A0A8M3AY19
uniprot id: A0A8M6Z204
uniprot id: A0A8M9QIZ6
uniprot id: F1R125
names: Similarity
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

7955:LOC108183587
gene id: 7955:LOC108183587
uniprot id: A0A8M6Z5Q0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:lix1l
gene id: 7955:lix1l
uniprot id: A0A8M1NJC0
uniprot id: A0A8M2B6G9
uniprot id: A3KQR9
names: Similarity
messages: Belongs to the LIX1 family.

7955:ugt5a2
gene id: 7955:ugt5a2
uniprot id: Q08C45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:gata3
gene id: 7955:gata3
uniprot id: A0A8M2BC08
uniprot id: A0A8M2BC31
uniprot id: A0A8M2BC50
uniprot id: A0A8M9Q5R9
uniprot id: B3DGG5
uniprot id: Q91428
names: Developmental Stage
names: Subcellular Location Annotation
messages: Expressed during gastrulation in the ventral region of the embryo which includes tissue fated to form the non-neural ectoderm.
messages: Nucleus

7955:sfxn5a
gene id: 7955:sfxn5a
uniprot id: A0A8M1P320
uniprot id: A0A8M3B7V4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

7955:vsx2
gene id: 7955:vsx2
uniprot id: A0A8M1P5K9
uniprot id: A0A8M2B589
uniprot id: F1QQE7
names: Subcellular Location Annotation
messages: Nucleus

7955:ddx3b
gene id: 7955:ddx3b
uniprot id: A0A8M2BG28
uniprot id: A0A8M2BG33
uniprot id: A0A8M2BG36
uniprot id: A0A8M2BG39
uniprot id: A0A8M2BGM7
uniprot id: Q6PBB2
names: Similarity
messages: Belongs to the DEAD box helicase family.

7955:fam101b
gene id: 7955:fam101b
uniprot id: A0A8M1RHN8
uniprot id: X1WD14
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

7955:znf408
gene id: 7955:znf408
uniprot id: A0A8M1P8Y9
uniprot id: E7FAN3
names: Subcellular Location Annotation
messages: Nucleus

7955:si:rp71-46j2.7
gene id: 7955:si:rp71-46j2.7
uniprot id: A0A140LGW1
uniprot id: A0A8M1RJ24
uniprot id: A0A8M3AI12
uniprot id: A0A8M3B0G2
names: Similarity
messages: Belongs to the sorting nexin family.

7955:cacng4a
gene id: 7955:cacng4a
uniprot id: A0A8M9QAW7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:si:dkey-46g23.5
gene id: 7955:si:dkey-46g23.5
uniprot id: A0A8M1NYK0
uniprot id: F1QS86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:si:ch73-278m9.1
gene id: 7955:si:ch73-278m9.1
uniprot id: A0A8M1RK17
uniprot id: A0A8M2BBQ2
names: Similarity
messages: Belongs to the ric-3 family.

7955:ambra1a
gene id: 7955:ambra1a
uniprot id: E7FAG6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat AMBRA1 family.
messages: Component of the DCX(AMBRA1) E3 ubiquitin ligase complex.
messages: Endoplasmic reticulum
messages: Expressed both maternally and zygotically. Present as maternal transcripts in the eggs and display a gradual decline until 8 hours post-fertilization (hpf), being replaced by zygotic mRNAs from 12 hpf onwards (PubMed:23348054). After 24 hpf, the transcripts are mainly localized in the brain and otic vesicles (PubMed:23348054).
messages: Mitochondrion
messages: Morpholino knockdown of ambra1a causes impaired dorso-ventral patterning in embryos (PubMed:23348054). Morpholino knockdown of ambra1a and ambra1b results in reduced autophagy and increased apoptosis during embryogenesis (PubMed:23348054). Morpholino knockdown of ambra1a and ambra1b results in impaired locomotion, caused by abnormal myogenesis (PubMed:24922546).
messages: Nucleus
messages: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle control and autophagy (PubMed:23348054). The DCX(AMBRA1) complex specifically mediates the polyubiquitination of target proteins (By similarity). Acts as an upstream master regulator of the transition from G1 to S cell phase: ambra1a specifically recognizes and binds phosphorylated cyclin-D (ccnd1, ccnd2 and ccnd3), leading to cyclin-D ubiquitination by the DCX(AMBRA1) complex and subsequent degradation (By similarity). Acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (eloc) component of CRL5 complexes (By similarity). Acts as a key regulator of autophagy by modulating the BECN1-PIK3C3 complex: controls protein turnover during neuronal development, and regulates normal cell survival and proliferation (By similarity). In normal conditions, ambra1a is tethered to the cytoskeleton via interaction with dyneins light chains (By similarity). Upon autophagy induction, ambra1a is released from the cytoskeletal docking site to induce autophagosome nucleation by mediating ubiquitination of proteins involved in autophagy (By similarity). Also acts as an activator of mitophagy (By similarity). Required for skeletal muscle development (PubMed:24922546).
messages: autophagosome
messages: cytoskeleton
messages: cytosol
messages: focal adhesion

7955:acot21
gene id: 7955:acot21
uniprot id: A0A8N7T759
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

7955:ugt2a1
gene id: 7955:ugt2a1
uniprot id: A0A8M1NX95
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

7955:si:ch211-157j23.2
gene id: 7955:si:ch211-157j23.2
uniprot id: A0A8M9PUA2
names: Similarity
messages: Belongs to the NXPE family.

7955:dpysl4
gene id: 7955:dpysl4
uniprot id: A0A0R4IYX8
uniprot id: A0A8M2BK77
uniprot id: A0A8M9Q8F2
uniprot id: Q52PJ4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

7955:g6pcb
gene id: 7955:g6pcb
uniprot id: A0A8M9Q9K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

7955:pxna
gene id: 7955:pxna
uniprot id: Q6R3L1
names: Subcellular Location Annotation
messages: cell cortex
messages: cytoskeleton
messages: focal adhesion

7955:or119-2
gene id: 7955:or119-2
uniprot id: Q2PRD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:cxcr3.2
gene id: 7955:cxcr3.2
uniprot id: E9QJ73
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Detected in developing macrophages at 28 hours post-fertilization (PubMed:20424185). Continues to be expressed in macrophages at 2 and 6 days post-fertilization (dpf) (PubMed:25573892). Also detected in neutrophils at 2 and 6 dpf (PubMed:25573892).
messages: Receptor for the C-X-C chemokines cxcl11.1 and cxcl11.6 (PubMed:25573892). Promotes macrophage chemotaxis to sites of bacterial infection (PubMed:20424185, PubMed:25573892).
messages: Viable with no significant effect on survival (PubMed:25573892). Macrophage and neutrophil counts are normal (PubMed:25573892). Macrophage migration in response to cxcr3.2-independent stimuli is not affected, although the basal migration rate is reduced (PubMed:25573892). Macrophage migration to sites of bacterial infection by S.typhimurium or M.marinum is reduced (PubMed:20424185, PubMed:25573892). Dissemination of bacterial infection to distant sites and granuloma formation is also reduced (PubMed:25573892).

7955:rin2
gene id: 7955:rin2
uniprot id: E7F662
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

7955:osbpl3b
gene id: 7955:osbpl3b
uniprot id: A0A8M3AI16
uniprot id: A0A8N7UTD4
uniprot id: F1R2E5
names: Similarity
messages: Belongs to the OSBP family.

7955:p2rx7
gene id: 7955:p2rx7
uniprot id: Q7SZM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

7955:pon2
gene id: 7955:pon2
uniprot id: Q6NXA5
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

7955:mrpl20
gene id: 7955:mrpl20
uniprot id: Q0P478
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

7955:LOC110439859
gene id: 7955:LOC110439859
uniprot id: A0A8M9QFP7
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:iqsec1a
gene id: 7955:iqsec1a
uniprot id: A0A8M6YVG6
names: Similarity
messages: Belongs to the BRAG family.

7955:jupb
gene id: 7955:jupb
uniprot id: A0A8M9PS81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Membrane
messages: desmosome

7955:nubpl
gene id: 7955:nubpl
uniprot id: Q6DH61
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

7955:slc16a3
gene id: 7955:slc16a3
uniprot id: F1Q7T3
uniprot id: Q7ZVM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

7955:itgb2
gene id: 7955:itgb2
uniprot id: A0A8N7TDC7
uniprot id: E7FCN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

7955:alpl
gene id: 7955:alpl
uniprot id: A0A8M1PDW2
uniprot id: A0A8M2BGI2
uniprot id: A0A8M9PUR2
uniprot id: F1Q5B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

7955:elovl6
gene id: 7955:elovl6
uniprot id: Q6PC64
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: N-Glycosylated.
messages: The reaction is stimulated by the presence of HSD17B12, the enzyme catalyzing the second step of the elongation cycle.

7955:zc2hc1c
gene id: 7955:zc2hc1c
uniprot id: A0A8M1PZC9
uniprot id: E7F5P9
names: Similarity
messages: Belongs to the ZC2HC1 family.

7955:ppp1r10
gene id: 7955:ppp1r10
uniprot id: A3KPX4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

7955:rad50
gene id: 7955:rad50
uniprot id: A0A8N7UW22
uniprot id: F8W411
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

7955:tsfm
gene id: 7955:tsfm
uniprot id: A1A5Z3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

7955:LOC559800
gene id: 7955:LOC559800
uniprot id: A0A8N7UVS6
uniprot id: F1REG3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7955:zgc:103586
gene id: 7955:zgc:103586
uniprot id: A0A8M9Q7T7
uniprot id: Q5U3F7
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

7955:itpkcb
gene id: 7955:itpkcb
uniprot id: A0A8M1P1A2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:oplah
gene id: 7955:oplah
uniprot id: E7F6Z6
names: Similarity
messages: Belongs to the oxoprolinase family.

7955:ca16b
gene id: 7955:ca16b
uniprot id: A0A8M1QQH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

7955:kiz
gene id: 7955:kiz
uniprot id: A0A2R8PWB6
uniprot id: A0A8M2B5C0
uniprot id: A5D8S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

7955:sfrp1a
gene id: 7955:sfrp1a
uniprot id: B0CM21
uniprot id: Q7T2K9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:drd3
gene id: 7955:drd3
uniprot id: A0A8M2B9M1
uniprot id: A0A8M9PTW6
uniprot id: F1QG18
uniprot id: Q8AWE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:pou2f2a
gene id: 7955:pou2f2a
uniprot id: A0A8M3AHW2
uniprot id: A0A8M3AQD8
uniprot id: A0A8M3AT79
uniprot id: A0A8M6YSU9
uniprot id: A0A8M6YVD3
uniprot id: A0A8M6Z1A5
uniprot id: A0A8M6Z1Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

7955:ppp2ca
gene id: 7955:ppp2ca
uniprot id: A9JT81
uniprot id: Q567Y8
names: Similarity
messages: Belongs to the PPP phosphatase family.

7955:phc3
gene id: 7955:phc3
uniprot id: A0A8M2BIM7
uniprot id: A0A8M3APW2
uniprot id: A0A8M3AQB7
uniprot id: A0A8M3AQC0
uniprot id: A0A8M3AXE5
uniprot id: A0A8M3B0E0
uniprot id: A0A8M3B7T7
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC798089
gene id: 7955:LOC798089
uniprot id: A0A8M2B2Q6
uniprot id: A0A8M9QN24
names: Function
messages: May be involved in neurite outgrowth.

7955:tshr
gene id: 7955:tshr
uniprot id: C0SKM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

7955:tprg1
gene id: 7955:tprg1
uniprot id: A4QP65
names: Similarity
messages: Belongs to the TPRG1 family.

7955:mhc1uka
gene id: 7955:mhc1uka
uniprot id: A0A8M2B625
names: Similarity
messages: Belongs to the MHC class I family.

7955:cryz
gene id: 7955:cryz
uniprot id: A5PN39
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

7955:dia1b
gene id: 7955:dia1b
uniprot id: A9JST5
uniprot id: F1QBM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

7955:gna13b
gene id: 7955:gna13b
uniprot id: A4FVJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

7955:LOC100002481
gene id: 7955:LOC100002481
uniprot id: A0A8M3B3L4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:arid1b
gene id: 7955:arid1b
uniprot id: A0A0R4ISW4
uniprot id: A0A2R8RJE4
uniprot id: A0A8M1P5H8
uniprot id: A0A8M1P9K2
uniprot id: A0A8M2B764
uniprot id: A0A8M2B773
uniprot id: A0A8M2B7I1
uniprot id: A0A8M3B3X6
names: Subcellular Location Annotation
messages: Nucleus

7955:bambia
gene id: 7955:bambia
uniprot id: Q6PCA4
uniprot id: Q9DFZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

7955:clca5.2
gene id: 7955:clca5.2
uniprot id: A0A8M3APN3
names: Similarity
messages: Belongs to the CLCR family.

7955:si:dkey-202l16.5
gene id: 7955:si:dkey-202l16.5
uniprot id: A0A8M2BB66
uniprot id: A0A8M3B8A3
uniprot id: E7FDU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

7955:nono
gene id: 7955:nono
uniprot id: A0A8M9PX41
uniprot id: Q802Z5
names: Subcellular Location Annotation
messages: Nucleus speckle

7955:vent
gene id: 7955:vent
uniprot id: Q78BZ1
uniprot id: Q9DGM9
names: Subcellular Location Annotation
messages: Nucleus

7955:slit1a
gene id: 7955:slit1a
uniprot id: A0A8M3BEE9
uniprot id: Q3S2J2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:zdhhc24
gene id: 7955:zdhhc24
uniprot id: Q6DG77
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:rprmb
gene id: 7955:rprmb
uniprot id: Q6PBK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle.
messages: Membrane

7955:ddx18
gene id: 7955:ddx18
uniprot id: Q6DRL1
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

7955:dars
gene id: 7955:dars
uniprot id: A0AUR8
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

7955:ggt5b
gene id: 7955:ggt5b
uniprot id: A0A8M1REQ8
uniprot id: E7FFJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

7955:LOC108190994
gene id: 7955:LOC108190994
uniprot id: A0A8M6Z0Q9
names: Subcellular Location Annotation
messages: Nucleus

7955:eno1b
gene id: 7955:eno1b
uniprot id: Q6PC89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

7955:si:ch73-63e15.2
gene id: 7955:si:ch73-63e15.2
uniprot id: A0A2R8PYX0
uniprot id: A0A8M1Q7N9
uniprot id: A0A8M3AXS4
uniprot id: E7F5T6
names: Similarity
messages: Belongs to the SBNO family.

7955:cd164
gene id: 7955:cd164
uniprot id: A4QP24
uniprot id: Q5TZ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

7955:becn1
gene id: 7955:becn1
uniprot id: F1RCP1
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beclin family.
messages: Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (By similarity). Interacts with the poly-Gln domain of ATXN3; the interaction causes deubiquitination at Lys-399 and stabilizes BECN1 (PubMed:28445460).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Endosome membrane
messages: Expanded poly-Gln tracts inhibit ATXN3-BECN1 interaction, decrease BECN1 levels and impair starvation-induced autophagy (PubMed:28445460).
messages: Expressed during follicle development in the ovary (PubMed:23195281).
messages: Mitochondrion membrane
messages: Plays a central role in autophagy (PubMed:24441423, PubMed:27467399, PubMed:28445460). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (By similarity). Involved in endocytosis including endosome formation in neuronal cells (By similarity).
messages: Polyubiquitinated at Lys-399 with 'Lys-48'-linkages (PubMed:28445460). 'Lys-48'-linked polyubiquitination of Lys-399 leads to degradation (PubMed:28445460). Deubiquitinated by ATXN3, leading to stabilization (PubMed:28445460).
messages: Results in defects in morphogenesis, increased numbers of dead cells, abnormal heart structure, and reduced organismal survival (PubMed:24441423). Reduces the regenerative response to muscle injury with accumulation of sarcomeric and nuclear debris (PubMed:27467399).
messages: The C-terminal evolutionary conserved domain (ECD) contains poly-Gln-binding domains such as the ATXN3 poly-Gln motif, consistent with structural docking models revealing two highly scored poly-Gln-binding pockets in the ECD. As some binding is observed with BECN1 lacking the ECD, other domains of BECN1 may also interact with ATXN3.
messages: The coiled coil domain can form antiparallel homodimers and mediates dimerization with the coiled coil domains of ATG14 or UVRAG involved in the formation of PI3K complexes.
messages: autophagosome
messages: trans-Golgi network membrane

7955:ptgdsa
gene id: 7955:ptgdsa
uniprot id: B3DI79
uniprot id: B3DI92
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

7955:LOC101884360
gene id: 7955:LOC101884360
uniprot id: A0A8M9PBX6
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

7955:olfm3a
gene id: 7955:olfm3a
uniprot id: A8KB73
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

7955:sost
gene id: 7955:sost
uniprot id: A0A8M9PX42
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the sclerostin family.
messages: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

7955:setd6
gene id: 7955:setd6
uniprot id: Q803K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

7955:hcn4
gene id: 7955:hcn4
uniprot id: A0A8N7UQR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

7955:vti1b
gene id: 7955:vti1b
uniprot id: Q7SY45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

7955:atp6v0d1
gene id: 7955:atp6v0d1
uniprot id: Q6PGV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Lysosome membrane
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (PubMed:21844891).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).

7955:hsd11b1la
gene id: 7955:hsd11b1la
uniprot id: Q6PUF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Secreted

7955:pgm1
gene id: 7955:pgm1
uniprot id: Q7SXW7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

7955:mtm1
gene id: 7955:mtm1
uniprot id: A0A8M3AU08
uniprot id: Q32PM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

7955:zgc:153169
gene id: 7955:zgc:153169
uniprot id: A0A8M1NBC1
uniprot id: A0A8M3BEP7
uniprot id: F1QE55
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

7955:abcg4b
gene id: 7955:abcg4b
uniprot id: A8KB77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7955:mpp7a
gene id: 7955:mpp7a
uniprot id: A0A8M3B7B3
uniprot id: A0A8M9PW28
uniprot id: A0A8M9Q869
uniprot id: Q6P0D7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity).
messages: Belongs to the MAGUK family.
messages: Membrane
messages: Was originally thought to be the ortholog of mammalian DLG3.
messages: adherens junction
messages: tight junction

7955:caspa
gene id: 7955:caspa
uniprot id: Q9I9L7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: During embryonic development, highly expressed at 8 hours post-fertilization (hpf) (PubMed:28402832). Expressed at the pharyngula stage at 24 hpf and expression is maintained 48 hpf, 72 hpf and to larval day 4 of development at 96 hpf (PubMed:29791492, PubMed:28402832). During this time, expressed in the pharyngeal arches, and in the intestinal bulb at 72 and 96 hpf (PubMed:29791492, PubMed:12464617). Also expressed in the epidermis and mouth at 48 and 72 hpf (PubMed:12464617).
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit (Probable). Interacts (via pyrin domain) with pycard (via pyrin domain) (PubMed:12464617, PubMed:29791979, PubMed:30150286). Interacts with caspb (PubMed:29791979). Component of NLRP1 inflammasomes (PubMed:30150286). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:30150286). The NLRP1 inflammasome is composed of the signal sensor nlrp1, and the adapter pycard (asc), which recruit effector pro-inflammatory caspases caspa and/or caspb (PubMed:30150286). The interaction between nlrp1 and pycard is required for the sequential recruitment of caspa and then caspb (PubMed:30150286). Caspa is preferentially recruited first and this causes the cleavage of pro-il1b into the midformed il1b (PubMed:30150286). This is followed by the recruitment of caspb, which is activated and cleaves the midformed il1b resulting in il1b maturation (PubMed:30150286). Interacts with caiap (PubMed:29123523).
messages: Inflammasome
messages: Morpholino knockdown in early embryos results in abnormalities in the development of the cartilaginous pharyngeal skeleton and eventually results in death upon exhaustion of the yolk (PubMed:12464617). Abnormalities include deformed and thinned Meckel's and palatoquadrate cartilages, deformed ceratohyal cartilages and disorganized branchial cartilages (PubMed:12464617). Morpholino knockdown in one- to four-cell stage embryos results in an open mouth phenotype (PubMed:12464617). Morpholino knockdown in one-cell embryos results in reduced survival in response to bacterial infection with E.tarda, but does not decrease caspb activation (PubMed:30150286). Morpholino knockdown in larvae results in no abnormalities in the brain, eyes or pectoral fins (PubMed:12464617).
messages: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
messages: Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis (PubMed:12464617, PubMed:30150286). Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation (PubMed:30150286). In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form (PubMed:30150286). Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu (PubMed:30150286). Required for the development of the cartilaginous pharyngeal skeleton (PubMed:12464617).
messages: Up-regulated in response to pentachlorophenol (PCP), a toxic pollutant (PubMed:28402832). Up-regulated in response to bacterial infection with E.tarda (PubMed:30150286).

7955:ptcd3
gene id: 7955:ptcd3
uniprot id: Q32LU7
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Mitochondrial RNA-binding protein that may have a role in mitochondrial translation.
messages: Mitochondrion

7955:cxcl19
gene id: 7955:cxcl19
uniprot id: A9ZPF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:myrf
gene id: 7955:myrf
uniprot id: A0A8M3ANV6
uniprot id: A0A8M3AWA7
uniprot id: A0A8M9P6L9
uniprot id: A0A8M9PH29
uniprot id: A0A8M9PV81
uniprot id: A0A8M9PYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

7955:LOC101885642
gene id: 7955:LOC101885642
uniprot id: A0A8M2B548
uniprot id: E7EXL7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:cdk10
gene id: 7955:cdk10
uniprot id: A0A8M1N531
uniprot id: A0A8M3AZU9
uniprot id: F1QKU6
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:wdr35
gene id: 7955:wdr35
uniprot id: A0A8M9Q9T9
uniprot id: A0A8N7UZ93
uniprot id: B7ZD88
names: Subcellular Location Annotation
messages: centrosome
messages: cilium basal body

7955:nr2c2
gene id: 7955:nr2c2
uniprot id: A0A8M1NIL0
uniprot id: A0A8M2BFE5
uniprot id: F6PDV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:cyp46a1.2
gene id: 7955:cyp46a1.2
uniprot id: A0A8M3AW06
uniprot id: Q7SY18
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:cldn18
gene id: 7955:cldn18
uniprot id: A0A0G2L7R9
uniprot id: A0A8M1RLM9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:pigu
gene id: 7955:pigu
uniprot id: A0A8M6YYR1
uniprot id: D5MQ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:foxi2
gene id: 7955:foxi2
uniprot id: Q6NY62
names: Subcellular Location Annotation
messages: Nucleus

7955:cnp
gene id: 7955:cnp
uniprot id: A0A8M3B0U8
uniprot id: E7FE19
names: Subcellular Location Annotation
messages: Membrane

7955:prkcbb
gene id: 7955:prkcbb
uniprot id: A0A2R8QMW2
uniprot id: A0A8M2BB79
uniprot id: Q7SY24
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by diacylglycerol which in turn phosphorylates a range of cellular proteins.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates isoform p66Shc of shc1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (andr)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation (By similarity).
messages: Cytoplasm
messages: Membrane
messages: Nucleus
messages: Phosphorylation on Thr-497 within the activation loop renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-638 maintains catalytic competence, and autophosphorylation on Ser-657 appears to release the kinase into the cytosol (By similarity).

7955:zgc:111976
gene id: 7955:zgc:111976
uniprot id: A0A8M1N6G4
uniprot id: F1QR19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

7955:LOC110437843
gene id: 7955:LOC110437843
uniprot id: A0A8M9PUV9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:kdelr2b
gene id: 7955:kdelr2b
uniprot id: Q6PH70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

7955:susd1
gene id: 7955:susd1
uniprot id: A0A8M3ARY2
uniprot id: A0A8M6Z6F2
uniprot id: A0A8M9PYC1
uniprot id: F1QRX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zmpste24
gene id: 7955:zmpste24
uniprot id: Q802Z1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

7955:cd40lg
gene id: 7955:cd40lg
uniprot id: B8YI05
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:six3b
gene id: 7955:six3b
uniprot id: O73709
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

7955:pias2
gene id: 7955:pias2
uniprot id: A0A8M1P805
uniprot id: A0A8M2BCP8
uniprot id: A0A8M2BCQ4
uniprot id: A2CE48
uniprot id: X1WFJ1
names: Similarity
messages: Belongs to the PIAS family.

7955:map4k3b
gene id: 7955:map4k3b
uniprot id: A0A8M3ARD5
uniprot id: A0A8M9Q2I4
uniprot id: A0A8M9Q6N4
uniprot id: X1WD89
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

7955:zgc:112175
gene id: 7955:zgc:112175
uniprot id: Q567B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

7955:impdh1b
gene id: 7955:impdh1b
uniprot id: A0A8M2BBW1
uniprot id: A0A8M2BC24
uniprot id: A0A8M6YXW5
uniprot id: Q5RGV0
uniprot id: Q5RGV1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

7955:l3hypdh
gene id: 7955:l3hypdh
uniprot id: A0A8M9PML3
names: Similarity
messages: Belongs to the proline racemase family.

7955:rec8b
gene id: 7955:rec8b
uniprot id: Q1RLS1
names: Subcellular Location Annotation
messages: Nucleus

7955:uros
gene id: 7955:uros
uniprot id: Q568K6
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

7955:chmp4bb
gene id: 7955:chmp4bb
uniprot id: B2GRA4
uniprot id: Q6IQ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).
messages: cytosol

7955:pmepa1
gene id: 7955:pmepa1
uniprot id: Q6DGX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

7955:si:dkey-102f14.5
gene id: 7955:si:dkey-102f14.5
uniprot id: A0A8M1NBT9
uniprot id: A0A8M2B5N3
uniprot id: Q1LV04
names: Similarity
messages: Belongs to the PHAF1 family.

7955:si:ch211-153b23.3
gene id: 7955:si:ch211-153b23.3
uniprot id: A0A0R4IB24
uniprot id: A0A8M9QKV1
names: Similarity
messages: Belongs to the SUA5 family.

7955:zufsp
gene id: 7955:zufsp
uniprot id: A0A8M1NC71
uniprot id: A0A8M2B580
uniprot id: A0A8M2B5A2
uniprot id: F1QAX5
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

7955:si:dkey-183i3.9
gene id: 7955:si:dkey-183i3.9
uniprot id: A0A0R4IYS6
uniprot id: A0A8M6YVC8
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:162183
gene id: 7955:zgc:162183
uniprot id: A0A8M6Z1F8
uniprot id: A4QNV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

7955:chrnb1l
gene id: 7955:chrnb1l
uniprot id: A0A8N7XJ23
uniprot id: E7F2Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:LOC101886064
gene id: 7955:LOC101886064
uniprot id: A0A8M3AIM4
names: Similarity
messages: Belongs to the helicase family.

7955:sema3fb
gene id: 7955:sema3fb
uniprot id: A0A8M9PVL8
uniprot id: A0A8M9Q7T2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:dgkaa
gene id: 7955:dgkaa
uniprot id: A0A2R8Q6S0
uniprot id: A0A8M2B985
uniprot id: Q1ECW5
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

7955:LOC100330882
gene id: 7955:LOC100330882
uniprot id: A0A8M9QCM8
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:slc1a2b
gene id: 7955:slc1a2b
uniprot id: A0A0R4IFU7
uniprot id: A0A8N7UZX7
uniprot id: D7RVR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

7955:atp2c1
gene id: 7955:atp2c1
uniprot id: A0A8M1RMK9
uniprot id: A0A8M2B4M0
uniprot id: F1REJ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

7955:hs3st2
gene id: 7955:hs3st2
uniprot id: A0MGY7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:gtpbp1
gene id: 7955:gtpbp1
uniprot id: A0A8M2BB58
uniprot id: A0A8M2BBB3
uniprot id: A0A8M9PEZ2
uniprot id: A0A8N1TRQ8
uniprot id: Q6PFN0
names: Function
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

7955:ppp3ca
gene id: 7955:ppp3ca
uniprot id: A0A8M1NVA3
uniprot id: A0A8M2B8B8
uniprot id: E9QD09
uniprot id: F1QD93
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

7955:foxd1
gene id: 7955:foxd1
uniprot id: A0A8M1PIM2
uniprot id: A2CE80
names: Subcellular Location Annotation
messages: Nucleus

7955:aldh4a1
gene id: 7955:aldh4a1
uniprot id: Q7SY23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldehyde dehydrogenase family.
messages: Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles (By similarity).
messages: Mitochondrion matrix

7955:sfxn2
gene id: 7955:sfxn2
uniprot id: A0A8M2BGR6
uniprot id: Q6NYD2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

7955:fam188b2
gene id: 7955:fam188b2
uniprot id: A0A8M9PIC2
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

7955:zgc:77849
gene id: 7955:zgc:77849
uniprot id: A0A0R4I9A2
uniprot id: A2BE76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a central player within a network of stress response pathways promoting cellular adaptability. Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage.
messages: Belongs to the HAPSTR1 family.
messages: Belongs to the TAPR1 family.
messages: Cytoplasm
messages: Nucleus
messages: Oligomer.

7955:ugt5a1
gene id: 7955:ugt5a1
uniprot id: Q32LS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:prkg1a
gene id: 7955:prkg1a
uniprot id: A0A8M2B3F1
uniprot id: Q7T2E5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

7955:si:ch211-139n6.11
gene id: 7955:si:ch211-139n6.11
uniprot id: A0A8M6Z339
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:cmtm8b
gene id: 7955:cmtm8b
uniprot id: A1L255
names: Subcellular Location Annotation
messages: Membrane

7955:dazap2
gene id: 7955:dazap2
uniprot id: Q6P4V6
uniprot id: Q6PBP9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

7955:mark2a
gene id: 7955:mark2a
uniprot id: A0A8M2B8C0
uniprot id: A0A8M2B8F7
uniprot id: A0A8M2B8K8
uniprot id: A0A8M3ALM5
uniprot id: A0A8M3ALN0
uniprot id: A0A8M3AMC2
uniprot id: A0A8M3AMD0
uniprot id: A0A8M3AU19
uniprot id: A0A8M3AU26
uniprot id: A0A8M3AX04
uniprot id: A0A8M3AX09
uniprot id: A0A8M3B4V1
uniprot id: A0A8M3B4V5
uniprot id: A0A8M3B4V9
uniprot id: E9QHU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

7955:psmc3ip
gene id: 7955:psmc3ip
uniprot id: Q6IQF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

7955:ust
gene id: 7955:ust
uniprot id: A0A8M3AWA0
uniprot id: B7ZUX1
uniprot id: Q402B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

7955:kctd13
gene id: 7955:kctd13
uniprot id: A9ULR9
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: According to a first report, morpholino-mediated knockdown of kctd13 leads to increased brain size and cell proliferation (PubMed:22596160). However, it was later shown that deletion of kctd13 does not cause any change in brain size or cell proliferation (PubMed:29088697). Experimental conditions used may explain discrepancies. A possible explanation being that morpholinos used in the first study, may have affected off-targets.
messages: Belongs to the BACURD family.
messages: Increased levels of RHOA. N ochange in brain size or neural progenitor cell proliferation is observed.
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (By similarity). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission (PubMed:29088697).

7955:v2ra20
gene id: 7955:v2ra20
uniprot id: A0A8M9PAP5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:tdo2b
gene id: 7955:tdo2b
uniprot id: A0A8M9QCY2
uniprot id: Q7SY53
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ikzf5
gene id: 7955:ikzf5
uniprot id: Q6DBW0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 'Pegasus' was the winged horse in Greek mythology.
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Probably self-associates.
messages: Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity).

7955:snu13a
gene id: 7955:snu13a
uniprot id: Q6NYU9
uniprot id: Q7ZU93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

7955:mpc2
gene id: 7955:mpc2
uniprot id: Q7ZUJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

7955:tor1l3
gene id: 7955:tor1l3
uniprot id: Q6P5L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

7955:LOC100536505
gene id: 7955:LOC100536505
uniprot id: A0A8M6Z0T4
names: Subcellular Location Annotation
messages: Cytoplasm

7955:si:ch73-308m11.1
gene id: 7955:si:ch73-308m11.1
uniprot id: A0A8M1QQI5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:chst3a
gene id: 7955:chst3a
uniprot id: B8A5X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

7955:ppfia1
gene id: 7955:ppfia1
uniprot id: A9JR75
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

7955:eya4
gene id: 7955:eya4
uniprot id: A0A0R4IA41
uniprot id: A0A8M1P0V5
uniprot id: A0A8M2B973
uniprot id: A0A8M2B979
uniprot id: A0A8M2B9F4
uniprot id: A0A8M3AYM8
uniprot id: A0A8M9P540
uniprot id: A0A8M9PF15
uniprot id: A0A8M9PKQ9
uniprot id: A0A8M9PT22
uniprot id: A0A8M9PT27
uniprot id: A0A8M9PWH1
uniprot id: E9QGZ3
uniprot id: E9QIR1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

7955:flad1
gene id: 7955:flad1
uniprot id: A0A0R4INK4
uniprot id: A0A8M2BGY9
uniprot id: A0A8M2BH00
uniprot id: Q68EH8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.
messages: The molybdenum cofactor biosynthesis protein-like region may not be functional.

7955:trim67
gene id: 7955:trim67
uniprot id: A0A8M1RRQ3
uniprot id: A0A8M3AKM3
uniprot id: A0A8M3B3X4
uniprot id: A0A8M9P2W2
uniprot id: A0A8M9PPT3
uniprot id: A0A8M9PT68
names: Subcellular Location Annotation
messages: cytoskeleton

7955:bsg
gene id: 7955:bsg
uniprot id: A0A0R4ICR8
uniprot id: A0A8M1PDN1
uniprot id: A0A8M3AUM8
uniprot id: Q6PH44
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lateral cell membrane

7955:sgpl1
gene id: 7955:sgpl1
uniprot id: A0A2R8Q3N8
uniprot id: A0A8M2B2S5
uniprot id: A4QNU7
names: Similarity
messages: Belongs to the group II decarboxylase family.

7955:trit1
gene id: 7955:trit1
uniprot id: A0A8M9PNA5
uniprot id: A0A8M9PRJ0
uniprot id: Q1LWL7
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

7955:zgc:101851
gene id: 7955:zgc:101851
uniprot id: Q66IB8
names: Similarity
messages: Belongs to the UPF0538 family.

7955:gmfb
gene id: 7955:gmfb
uniprot id: Q7ZUD3
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

7955:pcdh2g2
gene id: 7955:pcdh2g2
uniprot id: I6LD69
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:cox14
gene id: 7955:cox14
uniprot id: A8E7D3
names: Function
names: Subcellular Location Annotation
messages: Mitochondrion membrane
messages: Plays a role in the assembly or stability of the cytochrome c oxidase complex (COX).

7955:tor1
gene id: 7955:tor1
uniprot id: A0A8M1NXL2
uniprot id: A0A8M2B8C5
uniprot id: E9QG29
uniprot id: E9QHA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

7955:cyp2aa1
gene id: 7955:cyp2aa1
uniprot id: A4FVJ6
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:exoc1
gene id: 7955:exoc1
uniprot id: A0A286Y9W9
uniprot id: A0A2R8PY61
uniprot id: A0A8M2B7C5
uniprot id: A0A8M2B7E3
uniprot id: A0A8M2B7N4
uniprot id: A0A8M9P2G2
uniprot id: A0A8M9PBK9
uniprot id: A0A8M9PH55
uniprot id: Q7T2A6
names: Similarity
messages: Belongs to the SEC3 family.

7955:tmprss13b
gene id: 7955:tmprss13b
uniprot id: A0A8M1NC15
uniprot id: A0A8M2BCQ9
uniprot id: A5PF55
uniprot id: A9JTI2
uniprot id: E7EYC5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:dkey-175g6.5
gene id: 7955:si:dkey-175g6.5
uniprot id: A0A8M1Q1V9
uniprot id: E7F4K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

7955:afap1l1b
gene id: 7955:afap1l1b
uniprot id: A0A8M1NA49
uniprot id: A0A8M2B884
uniprot id: A0A8M9PQM4
uniprot id: E9QFQ2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in podosome and invadosome formation.
messages: invadopodium
messages: podosome

7955:ribc2
gene id: 7955:ribc2
uniprot id: A0A8M1NYQ7
uniprot id: E7F099
names: Similarity
messages: Belongs to the RIB43A family.

7955:ank2b
gene id: 7955:ank2b
uniprot id: A0A8M1PAL4
uniprot id: A0A8M9PNS3
uniprot id: A0A8M9PNT0
uniprot id: A0A8M9PNT4
uniprot id: A0A8M9PNT8
uniprot id: A0A8M9PNU3
uniprot id: A0A8M9PNU7
uniprot id: A0A8M9PNV1
uniprot id: A0A8M9Q1E3
uniprot id: A0A8M9Q1F0
uniprot id: A0A8M9Q1F7
uniprot id: A0A8M9Q1G4
uniprot id: A0A8M9Q1H0
uniprot id: A0A8M9Q1H7
uniprot id: A0A8M9Q1I2
uniprot id: A0A8M9Q1I9
uniprot id: A0A8M9Q7Q0
uniprot id: A0A8M9Q7Q4
uniprot id: A0A8M9Q7Q9
uniprot id: A0A8M9Q7R2
uniprot id: A0A8M9Q7R7
uniprot id: A0A8M9Q7S2
uniprot id: A0A8M9Q7S6
uniprot id: A0A8M9Q7T1
uniprot id: A0A8M9QBV0
uniprot id: A0A8M9QBV6
uniprot id: A0A8M9QBW2
uniprot id: A0A8M9QBW8
uniprot id: A0A8M9QBX3
uniprot id: A0A8M9QBY0
uniprot id: A0A8M9QGU1
uniprot id: A0A8M9QGU6
uniprot id: A0A8M9QGV2
uniprot id: A0A8M9QGV9
uniprot id: A0A8M9QGW4
uniprot id: A0A8M9QGX0
uniprot id: A0A8M9QGX6
uniprot id: A0A8M9QGY1
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:fgfr1op2
gene id: 7955:fgfr1op2
uniprot id: Q7T338
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIKE family.
messages: Cytoplasm

7955:stc1
gene id: 7955:stc1
uniprot id: Q0P481
names: Function
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.
messages: Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.

7955:LOC100331807
gene id: 7955:LOC100331807
uniprot id: A0A8M3AMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7955:ncapg
gene id: 7955:ncapg
uniprot id: A0A8M1P3E1
uniprot id: F1QJY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

7955:lin7b
gene id: 7955:lin7b
uniprot id: Q2M5E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-7 family.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.

7955:wasla
gene id: 7955:wasla
uniprot id: A0A8M9PGN8
uniprot id: A2RUY4
names: Subcellular Location Annotation
messages: Nucleus

7955:aspdh
gene id: 7955:aspdh
uniprot id: A0A8M9PUP6
uniprot id: G1K2M3
uniprot id: Q66I59
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

7955:slc25a32a
gene id: 7955:slc25a32a
uniprot id: A0A8M3AK35
uniprot id: Q7ZUN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:wfikkn1
gene id: 7955:wfikkn1
uniprot id: Q6NUX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WFIKKN family.
messages: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity).
messages: Secreted

7955:st7l
gene id: 7955:st7l
uniprot id: A9JRA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

7955:LOC101885062
gene id: 7955:LOC101885062
uniprot id: A0A8M2BLZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: extracellular matrix

7955:mitfb
gene id: 7955:mitfb
uniprot id: A0A8M9PEV1
uniprot id: A0A8N7XJ69
uniprot id: F1Q885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

7955:nrxn3a
gene id: 7955:nrxn3a
uniprot id: A0A8M9P070
uniprot id: A0A8M9P072
uniprot id: A0A8M9P074
uniprot id: A0A8M9P8Z3
uniprot id: A0A8M9P8Z6
uniprot id: A0A8M9P901
uniprot id: A0A8M9PEA6
uniprot id: A0A8M9PEB2
uniprot id: A0A8M9PKT1
uniprot id: A0A8M9PKT6
uniprot id: A0A8M9PKU0
uniprot id: A0A8M9PNT7
uniprot id: A1XQX8
names: Caution
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: After the very early developmental stages, the expression levels decrease and remain relatively constant until around 24 h, with the onset of an increase of expression that continues till the larval stages.
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
messages: Produced by alternative splicing.

7955:sgcb
gene id: 7955:sgcb
uniprot id: Q3ZB93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

7955:nol12
gene id: 7955:nol12
uniprot id: Q7ZWE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: May bind to rRNA.
messages: nucleolus

7955:LOC101882698
gene id: 7955:LOC101882698
uniprot id: A0A8M2BIX2
uniprot id: A0A8M9Q3K6
uniprot id: E7EYM3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:sesn3
gene id: 7955:sesn3
uniprot id: A0A8M1PHA2
uniprot id: F1R1P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

7955:pelp1
gene id: 7955:pelp1
uniprot id: A0A8M1PSB8
uniprot id: F1RE30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Cytoplasm
messages: Nucleus

7955:rae1
gene id: 7955:rae1
uniprot id: A0A2R8QJS5
uniprot id: A0A8M2BDK5
uniprot id: Q7ZWF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
messages: spindle pole

7955:foxj2
gene id: 7955:foxj2
uniprot id: A0A8N7TEH4
uniprot id: E7FA97
names: Subcellular Location Annotation
messages: Nucleus

7955:fcho1
gene id: 7955:fcho1
uniprot id: A0A8M3B1Y3
uniprot id: A0A8M9PRB3
uniprot id: A0A8M9Q3U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

7955:si:ch73-334d15.4
gene id: 7955:si:ch73-334d15.4
uniprot id: A0A8M1PUH5
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch211-113a14.28
gene id: 7955:si:ch211-113a14.28
uniprot id: A7MCA7
uniprot id: Q5BJA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-111 promotes monoubiquitination of Lys-119. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-119 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:zgc:158803
gene id: 7955:zgc:158803
uniprot id: A3KMT0
names: Similarity
messages: Belongs to the Luc7 family.

7955:LOC561083
gene id: 7955:LOC561083
uniprot id: A0A0R4IL38
uniprot id: A0A8M3AZ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:sox1a
gene id: 7955:sox1a
uniprot id: B2GNY1
uniprot id: Q6DGL6
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed zygotically. First detected at the tail bud stage and continues to be expressed for at least the first 48 hours of development.
messages: First detected at the tail bud stage in the forebrain. At the 3-somite stage, also expressed weakly in the hindbrain. At the 12-somite stage, strongly expressed in the forebrain and weakly expressed throughout the central nervous system. At the 21-somite stage, also expressed in the lens.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
messages: Transcriptional activator.

7955:golph3
gene id: 7955:golph3
uniprot id: Q503S3
uniprot id: Q5XJT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

7955:parp3
gene id: 7955:parp3
uniprot id: Q7ZVB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

7955:gpc2
gene id: 7955:gpc2
uniprot id: V5NF87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

7955:crabp2a
gene id: 7955:crabp2a
uniprot id: Q801Y4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

7955:ak3
gene id: 7955:ak3
uniprot id: A0A8M1PGD5
uniprot id: F1R4S7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

7955:kcnk15
gene id: 7955:kcnk15
uniprot id: A0A8M2B8P8
uniprot id: A0A8M2B910
uniprot id: A8KB52
uniprot id: F1Q5K8
uniprot id: F1RES8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:kcnf1a
gene id: 7955:kcnf1a
uniprot id: Q5SP96
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch73-106g13.1
gene id: 7955:si:ch73-106g13.1
uniprot id: A0A8M6Z4I0
names: Similarity
messages: Belongs to the WD repeat coronin family.

7955:nsfa
gene id: 7955:nsfa
uniprot id: A0A8M9PEX3
uniprot id: B7ZV62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

7955:bokb
gene id: 7955:bokb
uniprot id: B2GRX5
uniprot id: Q7T381
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Bcl-2 family.
messages: Expressed maternally but largely absent later in embryonic development. Also expressed in adult.
messages: Expressed strongly in ovary and more weakly in eye. Little expression in other tissues examined.
messages: May play a role in apoptosis. Does not appear to show pro-apoptotic activity when expressed ectopically in early embryos.
messages: Membrane

7955:ost4
gene id: 7955:ost4
uniprot id: A0A8M1P6L7
uniprot id: H0WEU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:oaz1a
gene id: 7955:oaz1a
uniprot id: Q9YI98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ODC antizyme family.
messages: Interacts with ODC1 and thereby sterically blocks ODC homodimerization.
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.

7955:ppm1g
gene id: 7955:ppm1g
uniprot id: A0A8M2BGW3
uniprot id: F1QJE5
uniprot id: Q7ZTW5
names: Similarity
messages: Belongs to the PP2C family.

7955:eif4g2a
gene id: 7955:eif4g2a
uniprot id: Q5KTT7
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

7955:st8sia4
gene id: 7955:st8sia4
uniprot id: Q6KC03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:atxn3
gene id: 7955:atxn3
uniprot id: A0A0R4ITP2
uniprot id: A0A8M1P7P2
uniprot id: A0A8M6YTS8
uniprot id: A0A8M9P030
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:opn1mw3
gene id: 7955:opn1mw3
uniprot id: A0A0N9NVT6
uniprot id: Q8AYM7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

7955:sostdc1a
gene id: 7955:sostdc1a
uniprot id: A7MCD1
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:slc38a6
gene id: 7955:slc38a6
uniprot id: Q503G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cell membrane
messages: Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.

7955:gria4a
gene id: 7955:gria4a
uniprot id: A0A8M6Z2V5
uniprot id: A0A8M6Z4D2
uniprot id: A0A8M6Z9L8
uniprot id: Q71E59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:hsd3b7
gene id: 7955:hsd3b7
uniprot id: F1QEV3
uniprot id: Q7ZVQ1
names: Similarity
messages: Belongs to the 3-beta-HSD family.

7955:gja8a
gene id: 7955:gja8a
uniprot id: A0A8N1Z0D3
uniprot id: B0S6Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:taf15
gene id: 7955:taf15
uniprot id: A0A8M2BKN1
uniprot id: A0A8M9QLF1
uniprot id: A0A8M9QPV6
uniprot id: A1A5X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

7955:slco1c1
gene id: 7955:slco1c1
uniprot id: A0A8M3B8P6
uniprot id: B3DJD4
uniprot id: Q5RIX3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:pkn1a
gene id: 7955:pkn1a
uniprot id: A0A8M2B6W0
uniprot id: A0A8M2B6W9
uniprot id: A0A8N7T5U2
uniprot id: E9QCG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

7955:mtx3
gene id: 7955:mtx3
uniprot id: A0A8M2BCT4
uniprot id: Q4VBW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metaxin family.
messages: Could function in transport of proteins into the mitochondrion.
messages: Membrane
messages: Mitochondrion
messages: Mitochondrion outer membrane
messages: Part of a large protein complex spanning both mitochondrial membranes termed the mitochondrial intermembrane space bridging (MIB) complex.

7955:prkar1aa
gene id: 7955:prkar1aa
uniprot id: A1A5T5
uniprot id: Q5I0F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

7955:musk
gene id: 7955:musk
uniprot id: Q5J1R8
uniprot id: Q5J1R9
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:foxp3a
gene id: 7955:foxp3a
uniprot id: A8WFW7
names: Subcellular Location Annotation
messages: Nucleus

7955:bpgm
gene id: 7955:bpgm
uniprot id: Q6DHM0
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

7955:si:ch73-380n15.2
gene id: 7955:si:ch73-380n15.2
uniprot id: A0A8M9PEJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:ccni
gene id: 7955:ccni
uniprot id: Q6NUZ7
names: Similarity
messages: Belongs to the cyclin family.

7955:pfkfb1
gene id: 7955:pfkfb1
uniprot id: A0A8M2B9A7
uniprot id: A2AR70
uniprot id: Q803Y6
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

7955:sult1st9
gene id: 7955:sult1st9
uniprot id: A0A8M3AVI4
uniprot id: A0A8M3B564
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:LOC101885477
gene id: 7955:LOC101885477
uniprot id: P0DPQ9
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Females are almost sterile: only 7 of 3024 eggs derived from mutant females develop into cleavage-stage embryos, as opposed to the majority of eggs from wild-type (PubMed:30190407). Both male and female fishes develop normally and are overtly healthy (PubMed:30190407). Males are fertile (PubMed:30190407).
messages: Highly expressed in oocytes (PubMed:30190407). Not expressed in testis (PubMed:30190407).
messages: N-glycosylated.
messages: Oocyte-expressed fertilization factor that mediates sperm-egg binding and is essential for sperm entry into the egg (PubMed:30190407). Necessary and sufficient to mediate species-specific gamete recognition and fertilization, which is essential for vertebrate species performing external fertilization (PubMed:30190407). External fertilization cannot guarantee that only conspecific sperm reaches the egg by precopulatory mate choice: proteins such as Bouncer can therefore support the selection of conspecific sperm (PubMed:30190407).
messages: Was named bouncer (bncr) in reference to the colloquial name of a security guard at a bar.

7955:si:ch211-114l13.10
gene id: 7955:si:ch211-114l13.10
uniprot id: A0A8M6YY09
names: Similarity
messages: Belongs to the NLRP family.

7955:p2ry2.2
gene id: 7955:p2ry2.2
uniprot id: A0A8M1Q7I1
uniprot id: E9QHJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:znrf1
gene id: 7955:znrf1
uniprot id: Q6P4U6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that plays a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity.
messages: Endosome
messages: Lysosome
messages: Membrane
messages: The RING-type zinc finger domain is required for E3 ligase activity.

7955:triob
gene id: 7955:triob
uniprot id: A0A8M3AHT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm

7955:cx27.5
gene id: 7955:cx27.5
uniprot id: Q2VJ87
uniprot id: Q2VJ88
uniprot id: Q9DF29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:plaua
gene id: 7955:plaua
uniprot id: A0A8M6Z265
uniprot id: D3GE88
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:kif5ab
gene id: 7955:kif5ab
uniprot id: A0A8M1PSD5
uniprot id: A0A8M3ATT8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:slc6a5
gene id: 7955:slc6a5
uniprot id: A0A2R8Q8E9
uniprot id: A0A8M3ATZ4
uniprot id: A0A8M3B0Z1
uniprot id: B3DFM7
uniprot id: Q5W8I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:si:dkey-51e6.1
gene id: 7955:si:dkey-51e6.1
uniprot id: A4FUK2
names: Similarity
messages: Belongs to the janus family.

7955:gxylt1b
gene id: 7955:gxylt1b
uniprot id: Q5SP46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
messages: Membrane

7955:zgc:101715
gene id: 7955:zgc:101715
uniprot id: Q66ID9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

7955:dync1li1
gene id: 7955:dync1li1
uniprot id: A0A0R4ICI6
uniprot id: A0A8M2B6A0
uniprot id: A0A8M3ASH7
uniprot id: A0A8M3AVG4
uniprot id: A3KPZ3
uniprot id: Q1LUM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

7955:purbb
gene id: 7955:purbb
uniprot id: Q6PHK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: May bind repeated elements in single-stranded DNA and may participate in transcriptional and translational gene regulation.
messages: Nucleus

7955:erbb3b
gene id: 7955:erbb3b
uniprot id: A0A8M2B911
uniprot id: A0A8M9P541
uniprot id: Q5G254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

7955:arpc4l
gene id: 7955:arpc4l
uniprot id: Q6NZZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

7955:p2ry1
gene id: 7955:p2ry1
uniprot id: A0A0N4SUG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:npffr1l1
gene id: 7955:npffr1l1
uniprot id: D2Y177
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

7955:flt3
gene id: 7955:flt3
uniprot id: A0A8M9PM96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:wnt2bb
gene id: 7955:wnt2bb
uniprot id: B3DHY3
uniprot id: Q1L130
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:lasp1
gene id: 7955:lasp1
uniprot id: A9JT31
uniprot id: Q6NYJ1
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

7955:gfod2
gene id: 7955:gfod2
uniprot id: A0A8M1NC49
uniprot id: F1R1S8
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

7955:krt93
gene id: 7955:krt93
uniprot id: Q1RLR3
names: Similarity
messages: Belongs to the intermediate filament family.

7955:zp2.1
gene id: 7955:zp2.1
uniprot id: A0A8M1N8C7
uniprot id: F1R003
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:prf1.5
gene id: 7955:prf1.5
uniprot id: A0A8N7UYU9
uniprot id: B0R0K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

7955:si:ch211-113j13.2
gene id: 7955:si:ch211-113j13.2
uniprot id: A0A8M9PIY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:cxxc1a
gene id: 7955:cxxc1a
uniprot id: Q6PGZ4
names: Subcellular Location Annotation
messages: Nucleus

7955:iqsec3a
gene id: 7955:iqsec3a
uniprot id: A0A8M3ART2
uniprot id: A0A8M3B1U5
uniprot id: A0A8M9Q145
uniprot id: A0A8M9Q6D3
uniprot id: A0A8M9QBX1
names: Similarity
messages: Belongs to the BRAG family.

7955:myh10
gene id: 7955:myh10
uniprot id: A0A8M3AT40
uniprot id: A0A8M3B073
uniprot id: A0A8M3B359
uniprot id: A0A8M3BA62
uniprot id: A0A8N7USR7
uniprot id: F1R3G4
uniprot id: I3ISA3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:si:dkey-197i20.6
gene id: 7955:si:dkey-197i20.6
uniprot id: A0A8N7UR65
uniprot id: X1WC39
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

7955:psmb6
gene id: 7955:psmb6
uniprot id: O57332
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

7955:slc25a24l
gene id: 7955:slc25a24l
uniprot id: A0A8M9PZP9
uniprot id: Q6DRB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:gnb5b
gene id: 7955:gnb5b
uniprot id: Q6PBY0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (PubMed:27523599).
messages: May interact with RGS9; this interaction stabilizes both proteins and increases RGS9 GTPase-activating protein (GAP) activity, hence accelerating the deactivation of D(2) dopamine receptor-mediated signaling.
messages: Membrane
messages: No visible phenotype; due to the redundancy with gnb5a. Simultaneous knockout of gnb5a and gnb5b results in no striking dysmorphologic features, but the larvae show impaired swimming activity, remain small, and generally die 7-14 days post fertilization (dpf), most likely as a result of their inability to feed.

7955:si:ch73-170l17.1
gene id: 7955:si:ch73-170l17.1
uniprot id: A0A8N7URH6
uniprot id: B0V3M5
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

7955:cxcl8a
gene id: 7955:cxcl8a
uniprot id: A0A0G2KYH9
uniprot id: A0A8M1Q7Q0
uniprot id: A0A8M3B7M3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

7955:gosr2
gene id: 7955:gosr2
uniprot id: B2GRI7
uniprot id: Q7T366
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

7955:cfap36
gene id: 7955:cfap36
uniprot id: Q1RM35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP36 family.
messages: Cytoplasm
messages: Nucleus
messages: flagellum

7955:tpd52
gene id: 7955:tpd52
uniprot id: A0A0R4IDA7
uniprot id: A0A8M2B679
uniprot id: A0A8M2B6B7
uniprot id: A0A8M2B6F1
uniprot id: A0A8M2B6H9
uniprot id: A0A8M3AL07
uniprot id: A0A8M6YWD3
uniprot id: A0A8M6Z2Z5
uniprot id: A3KNM2
uniprot id: I3IT45
names: Similarity
messages: Belongs to the TPD52 family.

7955:selt1a
gene id: 7955:selt1a
uniprot id: Q802F2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.
messages: Endoplasmic reticulum membrane
messages: Expressed in embryonic olfactory vesicles and the photoreceptor cell layer of the embryonic retina. Low level in embryonic epiphysis.
messages: May contain a selenide-sulfide bond between Cys-44 and Sec-47. This bond is speculated to serve as redox-active pair (By similarity).
messages: Selenoprotein with thioredoxin reductase-like oxidoreductase activity.

7955:hesx1
gene id: 7955:hesx1
uniprot id: P79738
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

7955:si:ch211-145o7.3
gene id: 7955:si:ch211-145o7.3
uniprot id: A0A8M1QHY1
uniprot id: A2CEM5
names: Subcellular Location Annotation
messages: Nucleus

7955:utp3
gene id: 7955:utp3
uniprot id: Q66I02
names: Similarity
messages: Belongs to the SAS10 family.

7955:ptpreb
gene id: 7955:ptpreb
uniprot id: A0A8M1NA63
uniprot id: A0A8M2B5P8
uniprot id: A0A8M6Z283
uniprot id: Q1MTF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

7955:spire1b
gene id: 7955:spire1b
uniprot id: A0A8M9NZX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

7955:sv2
gene id: 7955:sv2
uniprot id: A0A8M3API5
uniprot id: A0A8M3AZF8
uniprot id: F1QL71
names: Subcellular Location Annotation
messages: Membrane

7955:taar64
gene id: 7955:taar64
uniprot id: A0A8M1NCI7
uniprot id: Q5QNP9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:hs3st3b1b
gene id: 7955:hs3st3b1b
uniprot id: A0MGY9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:adat2
gene id: 7955:adat2
uniprot id: B3DKA9
uniprot id: Q5RIV4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

7955:esr2b
gene id: 7955:esr2b
uniprot id: A0A8M2B359
uniprot id: B8JJL3
uniprot id: B8JJL4
uniprot id: Q5PR29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

7955:psme2
gene id: 7955:psme2
uniprot id: Q9PUC4
names: Similarity
messages: Belongs to the PA28 family.

7955:patl1
gene id: 7955:patl1
uniprot id: A2RRV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAT1 family.
messages: Interacts with ribonucleoprotein complex components.
messages: Nucleus
messages: Nucleus speckle
messages: P-body
messages: PML body
messages: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly.

7955:kri1
gene id: 7955:kri1
uniprot id: Q6DRJ4
names: Similarity
messages: Belongs to the KRI1 family.

7955:gsta.1
gene id: 7955:gsta.1
uniprot id: F1R4Z8
uniprot id: Q6P962
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

7955:arhgap29b
gene id: 7955:arhgap29b
uniprot id: Q6PCS4
names: Function
messages: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42 (By similarity).

7955:irf2bp1
gene id: 7955:irf2bp1
uniprot id: Q1LV17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor.
messages: Belongs to the IRF2BP family.
messages: Nucleus

7955:yipf1
gene id: 7955:yipf1
uniprot id: Q68EH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

7955:rab11fip3
gene id: 7955:rab11fip3
uniprot id: A0A2R8QBM8
uniprot id: A0A8M1PAD8
uniprot id: A0A8M2B9Z5
names: Subcellular Location Annotation
messages: Cleavage furrow
messages: Endosome membrane
messages: Membrane
messages: Midbody
messages: Recycling endosome membrane

7955:abcc1
gene id: 7955:abcc1
uniprot id: A0A0R4IC81
uniprot id: A0A8M1PZJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

7955:grid2ipa
gene id: 7955:grid2ipa
uniprot id: A0A2R8RTP4
uniprot id: A0A8M3AQT5
names: Subcellular Location Annotation
messages: Nucleus

7955:lhfp
gene id: 7955:lhfp
uniprot id: B2GTL3
uniprot id: Q5PRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LHFP family.
messages: Membrane

7955:cpa1
gene id: 7955:cpa1
uniprot id: Q4VBJ2
names: Similarity
messages: Belongs to the peptidase M14 family.

7955:inhbab
gene id: 7955:inhbab
uniprot id: A1L1T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

7955:slc44a1b
gene id: 7955:slc44a1b
uniprot id: A0A8M9PZF9
uniprot id: A0A8M9QBA4
uniprot id: A0A8M9QGI9
uniprot id: A0A8M9QKS9
uniprot id: A0A8M9QPA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

7955:asf1bb
gene id: 7955:asf1bb
uniprot id: Q6NY34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

7955:xpr1a
gene id: 7955:xpr1a
uniprot id: B3DIW5
uniprot id: Q1LYM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

7955:sv2c
gene id: 7955:sv2c
uniprot id: A0A286Y8C7
uniprot id: A0A8M1NHD3
uniprot id: A0A8M2BCG9
uniprot id: A2CF25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

7955:spon1a
gene id: 7955:spon1a
uniprot id: O42113
names: Subcellular Location Annotation
messages: extracellular matrix

7955:riok3
gene id: 7955:riok3
uniprot id: Q6DEK0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

7955:si:ch211-139n6.3
gene id: 7955:si:ch211-139n6.3
uniprot id: A0A8M6Z344
uniprot id: A0A8M9QLB2
uniprot id: A0A8N7UTG6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:mvk
gene id: 7955:mvk
uniprot id: Q5U3I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
messages: Cytoplasm

7955:st3gal1l3
gene id: 7955:st3gal1l3
uniprot id: A0A8M9PP10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:cdc42se1
gene id: 7955:cdc42se1
uniprot id: Q6TEL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.
messages: cytoskeleton

7955:sox19a
gene id: 7955:sox19a
uniprot id: P47792
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed zygotically. First detected at the mid-blastula transition. Confined to the future ectoderm by the shield stage, and to the presumptive neuroectoderm by the 75-80% epiboly stage. From the tail bud to the 3-somite stage, expressed throughout the neural plate, except in the anterior margin; strongest expression in the presumptive ventral diencephalon. At the 12- to 25-somite stage, expressed broadly in the central nervous system. From 24-30 hours post-fertilization, restricted to the ventral diencephalon, midbrain and hindbrain/anterior spinal cord region, and to the retina and lens.
messages: Nucleus
messages: Transcriptional activator.

7955:dlx1a
gene id: 7955:dlx1a
uniprot id: Q98875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

7955:sbno1
gene id: 7955:sbno1
uniprot id: D6RUV3
names: Similarity
messages: Belongs to the SBNO family.

7955:si:ch211-191a24.4
gene id: 7955:si:ch211-191a24.4
uniprot id: B8JKC4
names: Subcellular Location Annotation
messages: Membrane

7955:ncoa2
gene id: 7955:ncoa2
uniprot id: A0A8M3AZ20
uniprot id: A0A8M9PG56
uniprot id: E7F5J8
uniprot id: F6NH98
uniprot id: Q98TW1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
messages: Contains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant (By similarity).
messages: Expressed ubiquitously in the embryo and in many adult tissues including the brain, gills, liver, swim bladder and skin. Shows highest expression in the ovary and testis, and lower expression in the intestine, eye and skin. Only isoform E20b is expressed in the muscle and heart.
messages: Interacts with the thyroid hormone receptors thraa and thrb (via the ligand-binding domain).
messages: Nucleus
messages: The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
messages: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (By similarity). Has a role in primitive myelopoiesis in the differentiation of granulocytes and macrophages. May play a role in the positive regulation of the circadian clock (By similarity).

7955:cfap53
gene id: 7955:cfap53
uniprot id: A0A0R4IFG5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CFAP53 family.
messages: First observed at tailbud stage in the developing Kupffer's vesicle, the zebrafish laterality organ. At the 10 somites stage, it is expressed in the otic vesicle and the floorplate. At 18 somites it is expressed in the pronephros. From 23 somites, it is no longer detected.
messages: Interacts with PIERCE1 and PIERCE2; the interactions link outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis (PubMed:26531781).
messages: Zebrafish mutants lacking cfap53 display total organ heterotaxia.
messages: cilium axoneme

7955:timm13
gene id: 7955:timm13
uniprot id: B2GSH6
uniprot id: Q6DGJ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Heterohexamer; composed of 3 copies of TIMM8 (TIMM8A or TIMM8B) and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of some proteins while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

7955:pir
gene id: 7955:pir
uniprot id: A0A8M1N0M7
uniprot id: F1QLW3
names: Similarity
messages: Belongs to the pirin family.

7955:dnase1l1l
gene id: 7955:dnase1l1l
uniprot id: Q6DH05
names: Similarity
messages: Belongs to the DNase I family.

7955:atp5ia
gene id: 7955:atp5ia
uniprot id: A7YY99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

7955:si:ch211-240b21.5
gene id: 7955:si:ch211-240b21.5
uniprot id: A0A0R4IK53
uniprot id: A0A8M1Q1G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

7955:en2a
gene id: 7955:en2a
uniprot id: B3DGA1
uniprot id: P09015
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Belongs to the engrailed homeobox family.
messages: Nucleus

7955:msx3
gene id: 7955:msx3
uniprot id: A0A8M1P7E7
uniprot id: Q7ZZ01
names: Subcellular Location Annotation
messages: Nucleus

7955:pgpep1
gene id: 7955:pgpep1
uniprot id: Q504F8
names: Similarity
messages: Belongs to the peptidase C15 family.

7955:agap2
gene id: 7955:agap2
uniprot id: A0A8M3AN70
uniprot id: A0A8M3ANW4
uniprot id: A0A8M3AVN4
uniprot id: A0A8M3AYQ6
uniprot id: A0JMI1
names: Similarity
messages: Belongs to the centaurin gamma-like family.

7955:LOC108191511
gene id: 7955:LOC108191511
uniprot id: A0A8M6Z8X3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:cnot6b
gene id: 7955:cnot6b
uniprot id: A8E4T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

7955:cox15
gene id: 7955:cox15
uniprot id: A0A8M1PE82
uniprot id: F1R355
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

7955:tmed2
gene id: 7955:tmed2
uniprot id: A0A8M9Q5S5
uniprot id: Q7ZW75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

7955:elovl4a
gene id: 7955:elovl4a
uniprot id: Q6PBM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Oligomer.

7955:fam8a1b
gene id: 7955:fam8a1b
uniprot id: Q56A52
names: Subcellular Location Annotation
messages: Membrane

7955:LOC797799
gene id: 7955:LOC797799
uniprot id: A0A8M6Z9M5
uniprot id: A7MC76
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:srsf5b
gene id: 7955:srsf5b
uniprot id: Q6DHJ0
names: Similarity
messages: Belongs to the splicing factor SR family.

7955:st6gal1
gene id: 7955:st6gal1
uniprot id: A0A8M2B878
uniprot id: A0A8M2B8A7
uniprot id: F1QK50
uniprot id: F1QMH5
uniprot id: Q6KB61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:capn2b
gene id: 7955:capn2b
uniprot id: Q504F5
names: Similarity
messages: Belongs to the peptidase C2 family.

7955:st6galnac5a
gene id: 7955:st6galnac5a
uniprot id: A0A8N7T7B6
uniprot id: F1Q5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:tle2
gene id: 7955:tle2
uniprot id: A0A8M2BHT3
uniprot id: A0A8M2BHU5
uniprot id: A0A8M2BI83
uniprot id: A0A8M3B5J1
uniprot id: B3DJR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

7955:aipl1
gene id: 7955:aipl1
uniprot id: A0A8M9PIP7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be important in protein trafficking and/or protein folding and stabilization.
messages: Nucleus

7955:zgc:171426
gene id: 7955:zgc:171426
uniprot id: A0A8M6YXV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:crygm2c
gene id: 7955:crygm2c
uniprot id: Q5XTP2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:LOC110438610
gene id: 7955:LOC110438610
uniprot id: A0A8M9P9N7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:tmem65
gene id: 7955:tmem65
uniprot id: B3DHU2
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expression is restricted to the heart (at protein level).
messages: May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (PubMed:26403541). Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity).
messages: Mitochondrion inner membrane
messages: Monomer. Homodimer. Interacts with GJA1.
messages: Morpholino knockdown of the protein causes pericardial edema and altered cardiac morphology in 4 days post-fertilization (dpf) embryos and severity increases as embryos age. Morrphants are not viable by 7 dpf. Hearts showed abnormal cardiac looping in the morphants and a significant decline in heart beat rates seen in after 4.5 dpf and continue decreasing at 5 and 6 dpf. Ventricles show a significant reduction in amplitude of Ca(2+) transients in morphants between 4 and 6 dpf.

7955:meaf6
gene id: 7955:meaf6
uniprot id: A0A0R4IX41
uniprot id: A0A8M2BLF2
uniprot id: Q6AZD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

7955:coq5
gene id: 7955:coq5
uniprot id: Q66L51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least coq3, coq4, coq5, coq6, coq7 and coq9.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

7955:bag6
gene id: 7955:bag6
uniprot id: A0A2R8QDI1
uniprot id: A0A8M2B4R7
uniprot id: Q7SZF4
names: Subcellular Location Annotation
messages: Nucleus
messages: extracellular exosome

7955:tceb1a
gene id: 7955:tceb1a
uniprot id: A0A8M2B9H7
uniprot id: E9QCI1
uniprot id: Q66IB1
names: Similarity
messages: Belongs to the SKP1 family.

7955:si:dkeyp-94h10.5
gene id: 7955:si:dkeyp-94h10.5
uniprot id: A0A8N1TS94
uniprot id: X1WDB2
names: Similarity
messages: Belongs to the mTERF family.

7955:ano10b
gene id: 7955:ano10b
uniprot id: A0A8M9P6G3
uniprot id: A0A8M9PGV6
uniprot id: Q08BD4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:prph2a
gene id: 7955:prph2a
uniprot id: Q66HW7
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

7955:tfe3b
gene id: 7955:tfe3b
uniprot id: A0A8M2BGM5
uniprot id: A0A8M2BGP5
uniprot id: A0A8M2BH69
uniprot id: A0A8M3B427
uniprot id: A0A8M6Z8P2
uniprot id: F1R1N1
uniprot id: Q7SZX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

7955:psmd4b
gene id: 7955:psmd4b
uniprot id: B2GPS9
uniprot id: Q561Y1
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

7955:rft1
gene id: 7955:rft1
uniprot id: A0A8N7TDL0
uniprot id: E7EXE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

7955:apobb.1
gene id: 7955:apobb.1
uniprot id: A0A8M1N7D8
uniprot id: A0A8M2B7H0
uniprot id: Q5TZ29
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ubn2a
gene id: 7955:ubn2a
uniprot id: A0A8M2BCZ5
uniprot id: A1L1Q5
uniprot id: I3ISA2
names: Similarity
messages: Belongs to the ubinuclein family.

7955:pthlhb
gene id: 7955:pthlhb
uniprot id: Q1L5E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

7955:si:dkeyp-75b4.8
gene id: 7955:si:dkeyp-75b4.8
uniprot id: A0A8M1Q1H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

7955:LOC799156
gene id: 7955:LOC799156
uniprot id: A0A8M1PUR3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:gal3st1a
gene id: 7955:gal3st1a
uniprot id: A2BGH3
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

7955:fnbp1l
gene id: 7955:fnbp1l
uniprot id: A0A0R4IAX0
uniprot id: A0A8M2BEA0
uniprot id: A0A8M9PQU2
uniprot id: A0A8M9QDQ3
uniprot id: Q6DEK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

7955:LOC795971
gene id: 7955:LOC795971
uniprot id: A0A8M9PV26
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:tmem136a
gene id: 7955:tmem136a
uniprot id: A0A8M1NZ90
uniprot id: E7F142
names: Subcellular Location Annotation
messages: Membrane

7955:zp3.2
gene id: 7955:zp3.2
uniprot id: Q4QRF0
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

7955:spo11
gene id: 7955:spo11
uniprot id: Q6P0S6
names: Similarity
messages: Belongs to the TOP6A family.

7955:si:ch211-282j17.13
gene id: 7955:si:ch211-282j17.13
uniprot id: E7FA55
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:rictorb
gene id: 7955:rictorb
uniprot id: A0A8M2B882
uniprot id: A0A8M3B4Q4
names: Similarity
messages: Belongs to the RICTOR family.

7955:arxb
gene id: 7955:arxb
uniprot id: A0A0G2KXF6
uniprot id: A0A8M1REJ1
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC110438781
gene id: 7955:LOC110438781
uniprot id: A0A8M9Q8M8
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:chrm5b
gene id: 7955:chrm5b
uniprot id: A0A8M1N7A3
uniprot id: Q5TYU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

7955:cyb5r4
gene id: 7955:cyb5r4
uniprot id: A0A8M2BKQ3
uniprot id: A0A8M2BKQ7
uniprot id: Q502I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum
messages: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway.

7955:napepld
gene id: 7955:napepld
uniprot id: A0A2R8RJ40
uniprot id: A0A8M2BC81
uniprot id: Q5TZE8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.
messages: Nucleus envelope

7955:fam155a
gene id: 7955:fam155a
uniprot id: A0A8M1QKK1
uniprot id: A0A8M3B1B8
uniprot id: A0A8M6Z8I4
uniprot id: E7FA63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NALF family.
messages: Membrane

7955:phactr2
gene id: 7955:phactr2
uniprot id: A0A8M2B304
uniprot id: A0A8M2B3R0
uniprot id: A0A8N7T6X4
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

7955:LOC110437735
gene id: 7955:LOC110437735
uniprot id: A0A8M9PYY8
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:crygm2d6
gene id: 7955:crygm2d6
uniprot id: Q6IQI4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:ier3ip1
gene id: 7955:ier3ip1
uniprot id: Q4VBI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YOS1 family.
messages: Endoplasmic reticulum membrane
messages: Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (By similarity). Acts as a regulator of the unfolded protein response (UPR) (By similarity).

7955:eif3f
gene id: 7955:eif3f
uniprot id: A0A8M1NXK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

7955:pcnxl2
gene id: 7955:pcnxl2
uniprot id: A0A2R8QI88
uniprot id: A0A8M2B3V3
uniprot id: A0A8N7TET3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

7955:aldh1a2
gene id: 7955:aldh1a2
uniprot id: Q90XS8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7955:zgc:114188
gene id: 7955:zgc:114188
uniprot id: Q5BJA1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

7955:si:ch73-62b13.1
gene id: 7955:si:ch73-62b13.1
uniprot id: Q1LWC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

7955:aldob
gene id: 7955:aldob
uniprot id: Q8JH71
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: Homotetramer.
messages: centriolar satellite

7955:LOC110438198
gene id: 7955:LOC110438198
uniprot id: A0A8M9PQ45
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:fam168b
gene id: 7955:fam168b
uniprot id: A0A0R4IF02
uniprot id: A0A8M2B9Y2
uniprot id: A0A8M9P5X8
uniprot id: A0A8M9PG28
uniprot id: Q08BY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM168 family.
messages: Cell membrane
messages: Inhibitor of neuronal axonal outgrowth.
messages: axon
messages: perinuclear region

7955:fam69aa
gene id: 7955:fam69aa
uniprot id: Q1RLQ5
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

7955:hdac7a
gene id: 7955:hdac7a
uniprot id: A0A8M9PX70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

7955:si:ch73-265d7.2
gene id: 7955:si:ch73-265d7.2
uniprot id: E9QBW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

7955:LOC110437731
gene id: 7955:LOC110437731
uniprot id: A0A8M1RIT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

7955:cd27
gene id: 7955:cd27
uniprot id: A0A8M9PE03
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:bsx
gene id: 7955:bsx
uniprot id: Q1LY36
uniprot id: Q6R3Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain.
messages: Nucleus

7955:foxn1
gene id: 7955:foxn1
uniprot id: F1R9K2
uniprot id: Q7ZTC0
names: Subcellular Location Annotation
messages: Nucleus

7955:rps12
gene id: 7955:rps12
uniprot id: Q6PC90
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

7955:LOC101885631
gene id: 7955:LOC101885631
uniprot id: A0A8M9PZQ9
names: Subcellular Location Annotation
messages: Membrane

7955:dpt
gene id: 7955:dpt
uniprot id: Q29RF0
names: Similarity
messages: Belongs to the dermatopontin family.

7955:vps4a
gene id: 7955:vps4a
uniprot id: A0A8M3AP98
uniprot id: Q08BZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

7955:slc50a1
gene id: 7955:slc50a1
uniprot id: Q5EB14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Mediates sugar transport across membranes.

7955:grik2
gene id: 7955:grik2
uniprot id: A0A8M9P836
uniprot id: A0A8M9PDB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:stat5b
gene id: 7955:stat5b
uniprot id: Q68SP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

7955:si:dkeyp-123h10.2
gene id: 7955:si:dkeyp-123h10.2
uniprot id: A0A8M9QGD4
uniprot id: B8A5Y8
names: Function
messages: May be involved in neurite outgrowth.

7955:max
gene id: 7955:max
uniprot id: A0A8M2B7H4
uniprot id: A0A8M2B7R2
uniprot id: Q5SPG2
uniprot id: Q6NY29
uniprot id: Q803J7
names: Similarity
messages: Belongs to the MAX family.

7955:cacna1da
gene id: 7955:cacna1da
uniprot id: A0A8M9PUS4
uniprot id: A0A8M9PUS9
uniprot id: A0A8M9Q738
uniprot id: A0A8M9Q745
uniprot id: A0A8M9QD03
uniprot id: A0A8M9QD08
uniprot id: A0A8M9QHK0
uniprot id: A0A8M9QHK6
uniprot id: A0A8M9QLJ7
uniprot id: Q6QRQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

7955:tspan37
gene id: 7955:tspan37
uniprot id: A0A8M1P6D4
uniprot id: E9QH97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:LOC100331400
gene id: 7955:LOC100331400
uniprot id: A0A8M9PZA8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:cand1
gene id: 7955:cand1
uniprot id: Q802V5
names: Similarity
messages: Belongs to the CAND family.

7955:dmtf1
gene id: 7955:dmtf1
uniprot id: Q6DG03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMTF1 family.
messages: Nucleus
messages: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'.

7955:crb2b
gene id: 7955:crb2b
uniprot id: A0A8M6Z842
uniprot id: Q1A5L1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:acot18
gene id: 7955:acot18
uniprot id: A0A8M1NYX7
uniprot id: A8WG99
uniprot id: Q5RH35
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

7955:cyp3a65
gene id: 7955:cyp3a65
uniprot id: Q32LT1
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:tldc1
gene id: 7955:tldc1
uniprot id: Q1LWV7
names: Function
names: Subcellular Location Annotation
messages: Activates an alternative mTOR signaling to regulate cell proliferation and migration.
messages: Cytoplasm
messages: Lysosome
messages: Membrane

7955:tlr5b
gene id: 7955:tlr5b
uniprot id: A0A8M1NIN6
uniprot id: F8W3J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

7955:cspg4
gene id: 7955:cspg4
uniprot id: A0A8M1QLR5
uniprot id: E7FCN9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:mylkb
gene id: 7955:mylkb
uniprot id: A0A8M3BA99
uniprot id: E7FDK2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

7955:pcdh2g3
gene id: 7955:pcdh2g3
uniprot id: I6LD70
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:dock10
gene id: 7955:dock10
uniprot id: A0A8M1Q7K9
uniprot id: A0A8M9NYD6
uniprot id: A0A8M9P713
uniprot id: X1WF60
names: Similarity
messages: Belongs to the DOCK family.

7955:cpt1b
gene id: 7955:cpt1b
uniprot id: F6P7Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:tmem150aa
gene id: 7955:tmem150aa
uniprot id: Q0P401
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

7955:ace2
gene id: 7955:ace2
uniprot id: A0A8M2BGN5
uniprot id: A0A8M2BGQ7
uniprot id: E7F9E5
uniprot id: Q5U380
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

7955:arhgef18a
gene id: 7955:arhgef18a
uniprot id: A0A8M3AXD6
uniprot id: F1REH9
uniprot id: Q6NSP2
names: Subcellular Location Annotation
messages: Cytoplasm

7955:si:ch211-214j8.1
gene id: 7955:si:ch211-214j8.1
uniprot id: A2BGQ8
uniprot id: B7ZUT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

7955:aida
gene id: 7955:aida
uniprot id: Q6PBN2
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by axin/JNK-signaling.
messages: At 24 hours post-fertilization, expressed in most tissues, with strongest expression in the brain and somites.
messages: Belongs to the AIDA family.
messages: Expressed both maternally and zygotically.

7955:msl1a
gene id: 7955:msl1a
uniprot id: A9JRX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the msl-1 family.
messages: Component of a multisubunit histone acetyltransferase complex (MSL).
messages: Component of histone acetyltransferase complex. Within MSL complex, promotes ubiquitination of histone H2B.
messages: Nucleus
messages: Nucleus speckle
messages: nucleoplasm

7955:dnah3
gene id: 7955:dnah3
uniprot id: A0A8M3ANU1
names: Similarity
messages: Belongs to the dynein heavy chain family.

7955:lrrc3
gene id: 7955:lrrc3
uniprot id: A8WHP9
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC3 family.
messages: C-terminus of translation can be extended by 1 residue.
messages: Membrane

7955:adcy3a
gene id: 7955:adcy3a
uniprot id: A0A8M1NT79
uniprot id: A0A8M3AIU8
uniprot id: A0A8M3AT35
uniprot id: E7FDV3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

7955:si:ch211-247n2.1
gene id: 7955:si:ch211-247n2.1
uniprot id: A0A8M1Q1J3
uniprot id: A0A8M2BK33
uniprot id: A0A8M9Q7I2
uniprot id: E7FCW4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:rfc5
gene id: 7955:rfc5
uniprot id: Q6DRK4
names: Similarity
messages: Belongs to the activator 1 small subunits family.

7955:jag1b
gene id: 7955:jag1b
uniprot id: A0A8M1PCD3
uniprot id: F1R986
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

7955:LOC100334526
gene id: 7955:LOC100334526
uniprot id: A0A8M9PCS2
names: Similarity
messages: Belongs to the peptidase S28 family.

7955:si:dkey-79d12.5
gene id: 7955:si:dkey-79d12.5
uniprot id: A0A8M1RJ53
uniprot id: A0A8M9P8B7
uniprot id: E7F2Z6
names: Similarity
messages: Belongs to the BTG family.

7955:cul4b
gene id: 7955:cul4b
uniprot id: A0A8M1NIA7
uniprot id: F8W428
names: Similarity
messages: Belongs to the cullin family.

7955:bet1l
gene id: 7955:bet1l
uniprot id: Q68EL3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of a SNARE complex consisting of stx5, ykt6, gosr2 and bet1l.
messages: Golgi apparatus membrane
messages: Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).

7955:cxcl11.5
gene id: 7955:cxcl11.5
uniprot id: A0A8M9Q9M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:zgc:103678
gene id: 7955:zgc:103678
uniprot id: Q66I65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

7955:LOC797518
gene id: 7955:LOC797518
uniprot id: A0A8M9Q7W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

7955:zdhhc13
gene id: 7955:zdhhc13
uniprot id: A0A0R4IQZ2
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it belongs to the DHHC palmitoyltransferase family, lacks the conserved active site cysteine residue at position 479 and may lack catalytic activity.
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Probably maternally supplied, the zygotic expression becomes significative at shield stage (6 hpf) and then decreases after 7.5 hpf but is still detected at 24 hpf.
messages: Putative palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:arl11
gene id: 7955:arl11
uniprot id: Q7ZVD8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7955:pex1
gene id: 7955:pex1
uniprot id: D2CK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

7955:mfsd4aa
gene id: 7955:mfsd4aa
uniprot id: Q7SXB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

7955:ebag9
gene id: 7955:ebag9
uniprot id: Q7ZWA8
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

7955:LOC101886340
gene id: 7955:LOC101886340
uniprot id: A0A8M2BLS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

7955:mpeg1.1
gene id: 7955:mpeg1.1
uniprot id: Q7SXE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

7955:ppp2r4
gene id: 7955:ppp2r4
uniprot id: A2CF49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7955:sgta
gene id: 7955:sgta
uniprot id: Q6NXA1
names: Similarity
messages: Belongs to the SGT family.

7955:si:dkey-165a24.9
gene id: 7955:si:dkey-165a24.9
uniprot id: E7F793
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:v2rl1
gene id: 7955:v2rl1
uniprot id: A0A8M3AV12
uniprot id: A8E7K1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:cnksr3
gene id: 7955:cnksr3
uniprot id: A8WG10
names: Similarity
messages: Belongs to the CNKSR family.

7955:angel2
gene id: 7955:angel2
uniprot id: Q5RGT6
names: Similarity
messages: Belongs to the CCR4/nocturin family.

7955:ing5b
gene id: 7955:ing5b
uniprot id: A0A8M2BIJ2
uniprot id: Q6AXK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

7955:ncoa1
gene id: 7955:ncoa1
uniprot id: A0A8M3AWF7
uniprot id: A0A8M9PTD7
uniprot id: Q5RIG3
names: Similarity
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.

7955:mctp1b
gene id: 7955:mctp1b
uniprot id: A0A0R4IF57
uniprot id: A0A8M1RRA4
uniprot id: A0A8M3BDE8
names: Subcellular Location Annotation
messages: Membrane

7955:LOC101884556
gene id: 7955:LOC101884556
uniprot id: A0A8M2BLS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:klhl21
gene id: 7955:klhl21
uniprot id: A0A8M9P526
uniprot id: Q6NYM1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of cul3, klhl21 and rbx1.
messages: Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity).
messages: spindle

7955:tubgcp2
gene id: 7955:tubgcp2
uniprot id: Q7SYD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

7955:frg1
gene id: 7955:frg1
uniprot id: Q566W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

7955:rnf8
gene id: 7955:rnf8
uniprot id: Q803C1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNF8 family.
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the rnf8 homodimer and a E2 heterodimer of ube2n and ube2v2.
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1.

7955:xpo6
gene id: 7955:xpo6
uniprot id: Q8QHJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.
messages: Nucleus

7955:otc
gene id: 7955:otc
uniprot id: A0A8M1PRZ4
uniprot id: E9QHD9
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

7955:acat1
gene id: 7955:acat1
uniprot id: Q6AZA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Homotetramer.
messages: Mitochondrion
messages: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.

7955:aebp2
gene id: 7955:aebp2
uniprot id: Q7SXV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AEBP2/jing C2H2-type zinc-finger family.
messages: DNA-binding transcriptional repressor. May interact with and stimulate the activity of histone methyltransferase complexes.
messages: Nucleus

7955:tmem41b
gene id: 7955:tmem41b
uniprot id: A1A5V7
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Endomembrane system
messages: Endoplasmic reticulum membrane
messages: Morpholino knockdown of the protein causes severe defects in motor neuron axonal outgrowth.
messages: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by atg2 (atg2a or atg2b) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (PubMed:23063131).
messages: The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.

7955:LOC100331268
gene id: 7955:LOC100331268
uniprot id: A0A8M1RH25
uniprot id: A0A8M9PM28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

7955:ppiab
gene id: 7955:ppiab
uniprot id: Q6IQN4
uniprot id: Q6PC53
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7955:ctnna2
gene id: 7955:ctnna2
uniprot id: A0A8M2B6X9
uniprot id: B7ZC77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Cytoplasm
messages: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system.
messages: Membrane
messages: Nucleus
messages: adherens junction
messages: axon
messages: cytoskeleton

7955:si:ch211-152f23.5
gene id: 7955:si:ch211-152f23.5
uniprot id: A3KPA9
uniprot id: D3GDI9
names: Similarity
messages: Belongs to the cyclin family.

7955:zdhhc20b
gene id: 7955:zdhhc20b
uniprot id: A0A8M1PUY2
uniprot id: A0A8M2B9Q3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:nr5a5
gene id: 7955:nr5a5
uniprot id: A0A8M1NBN2
uniprot id: B3DKN2
uniprot id: F1QKV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

7955:lipib
gene id: 7955:lipib
uniprot id: A0A8M1Q7Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

7955:si:ch73-362m14.4
gene id: 7955:si:ch73-362m14.4
uniprot id: A0A8M1RTE9
uniprot id: I3ITM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

7955:LOC100005536
gene id: 7955:LOC100005536
uniprot id: A0A8M9PNK8
names: Subcellular Location Annotation
messages: Cytoplasm

7955:pi4k2a
gene id: 7955:pi4k2a
uniprot id: Q6PE18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Membrane raft
messages: Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
messages: Mitochondrion
messages: Perikaryon
messages: Presynaptic cell membrane
messages: dendrite
messages: neuron projection
messages: synaptosome
messages: trans-Golgi network membrane

7955:naprt
gene id: 7955:naprt
uniprot id: A0A8M1PF80
uniprot id: A0A8M2BHL0
uniprot id: B8JLT0
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

7955:ascl1b
gene id: 7955:ascl1b
uniprot id: Q90260
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: First detected at 10 hours post-fertilization (hpf) increasing over the next 24 hours, then decreasing between 48 and 72 hours. Not detected in adult.
messages: In the 24 hours embryo, expressed in hindbrain close to the anterior and posterior boundaries of rhombomeres 2-6 and in ventral cells close to the floor plate of most rhombomeres. Also expressed in the telencephalon, diencephalon, tegmentum and spinal cord at sites distinct from those expressing ascl1a. Not expressed in the adenohypophysis.
messages: Nucleus
messages: Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. May mediate transcription activation by binding to the E box-containing promoter.

7955:LOC560461
gene id: 7955:LOC560461
uniprot id: A0A0G2L9N5
uniprot id: A0A2R8Q8B1
uniprot id: A0A2R8Q8W8
uniprot id: A0A8M3AV51
uniprot id: A0A8M6YZZ1
uniprot id: A0A8M6Z2A5
uniprot id: A0A8M6Z7T7
uniprot id: A0A8M6Z874
uniprot id: A0A8M9PZE8
names: Similarity
messages: Belongs to the BRAG family.

7955:unc50
gene id: 7955:unc50
uniprot id: B2GQ38
uniprot id: Q7ZUU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Golgi apparatus membrane
messages: Involved in the cell surface expression of neuronal nicotinic receptors (By similarity). Binds RNA (By similarity).
messages: Membrane
messages: Nucleus inner membrane

7955:rps8b
gene id: 7955:rps8b
uniprot id: B5DDE8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

7955:rbx1
gene id: 7955:rbx1
uniprot id: A4FUL3
names: Similarity
messages: Belongs to the RING-box family.

7955:s1pr5a
gene id: 7955:s1pr5a
uniprot id: A0A8M1N3A0
uniprot id: F1Q7W7
uniprot id: T2HFW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7955:LOC110438165
gene id: 7955:LOC110438165
uniprot id: A0A8M9PT13
names: Subcellular Location Annotation
messages: Membrane

7955:acbd6
gene id: 7955:acbd6
uniprot id: Q4V8X4
names: Function
names: Subcellular Location Annotation
messages: Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA. Does not bind fatty acids (By similarity).
messages: Cytoplasm

7955:ccr10
gene id: 7955:ccr10
uniprot id: Q6DG12
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:amn
gene id: 7955:amn
uniprot id: A0A8M9QAN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:fam124a
gene id: 7955:fam124a
uniprot id: A0A8M1QR29
uniprot id: A0A8M2BF08
uniprot id: A0A8M3AW10
uniprot id: F1Q587
names: Similarity
messages: Belongs to the FAM124 family.

7955:LOC110438154
gene id: 7955:LOC110438154
uniprot id: A0A8M9P2H3
names: Similarity
messages: Belongs to the ANKRD34 family.

7955:nadk2
gene id: 7955:nadk2
uniprot id: A0A0R4IKV3
uniprot id: A0A8M2B840
uniprot id: A0A8M2B8E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

7955:LOC101885235
gene id: 7955:LOC101885235
uniprot id: A0A8M2BI86
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:wu:fe02h09
gene id: 7955:wu:fe02h09
uniprot id: A0A2R8QFW3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

7955:ccdc85al
gene id: 7955:ccdc85al
uniprot id: A0A8M2BCZ4
uniprot id: A0A8M2BD30
uniprot id: A0A8M3AT27
uniprot id: A0A8M3B342
uniprot id: F6PBX1
uniprot id: Q66HU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

7955:armc9
gene id: 7955:armc9
uniprot id: A0A8M9P4U6
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cilium basal body

7955:si:ch73-167i17.6
gene id: 7955:si:ch73-167i17.6
uniprot id: A0A8M2BH52
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

7955:si:ch211-132b12.2
gene id: 7955:si:ch211-132b12.2
uniprot id: A0A8N7UYB8
uniprot id: Q1LVJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:LOC100331149
gene id: 7955:LOC100331149
uniprot id: A0A8M1RLH0
uniprot id: A0A8M3B820
uniprot id: A0A8M9NZ51
names: Similarity
messages: Belongs to the OSBP family.

7955:prkg1l
gene id: 7955:prkg1l
uniprot id: A0A8M6Z2D7
uniprot id: A0A8M9PRK8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

7955:desma
gene id: 7955:desma
uniprot id: A0A8M1PA74
uniprot id: A0A8N7UZE8
uniprot id: F1R8W3
uniprot id: F1R8W4
names: Similarity
messages: Belongs to the intermediate filament family.

7955:fgf23
gene id: 7955:fgf23
uniprot id: Q5MK87
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7955:LOC110439889
gene id: 7955:LOC110439889
uniprot id: A0A8M9Q180
uniprot id: A0A8M9QBN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:map4k3a
gene id: 7955:map4k3a
uniprot id: A0A8M3AXT8
uniprot id: A0A8M3B465
uniprot id: A0A8M3B704
uniprot id: A0A8M9PVK2
uniprot id: A0A8M9Q7S1
uniprot id: A0A8M9QI59
uniprot id: E7F7S9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

7955:tshz3b
gene id: 7955:tshz3b
uniprot id: A0A0R4IDX7
uniprot id: E1AZ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

7955:LOC110440104
gene id: 7955:LOC110440104
uniprot id: E7EXN4
names: Subcellular Location Annotation
messages: Golgi apparatus membrane

7955:zgc:86725
gene id: 7955:zgc:86725
uniprot id: F1RCB6
names: Similarity
messages: Belongs to the actin family.

7955:ccl19a.1
gene id: 7955:ccl19a.1
uniprot id: A2BIR2
uniprot id: A9ZPF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

7955:si:ch211-157j23.3
gene id: 7955:si:ch211-157j23.3
uniprot id: A0A8M6Z437
names: Similarity
messages: Belongs to the NXPE family.

7955:srrt
gene id: 7955:srrt
uniprot id: A0A8M2BC89
uniprot id: Q66I22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity). Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).
messages: Belongs to the ARS2 family.
messages: Cytoplasm
messages: Interacts ncbp1/cbp80.
messages: nucleoplasm

7955:zgc:113984
gene id: 7955:zgc:113984
uniprot id: A8E503
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:crygm2d18
gene id: 7955:crygm2d18
uniprot id: Q6IQK6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:cast
gene id: 7955:cast
uniprot id: A0A0R4ILE0
uniprot id: A0A0R4IPE6
uniprot id: A0A8M1NI55
uniprot id: A0A8M2B7Y0
uniprot id: A0A8M2B7Y1
uniprot id: A0A8M2B7Y5
uniprot id: A0A8M2B7Y6
uniprot id: A0A8M2B7Y7
uniprot id: A0A8M2B7Z1
uniprot id: A0A8M2B7Z3
uniprot id: A0A8M2B7Z6
uniprot id: A0A8M2B7Z9
uniprot id: A0A8M2B800
uniprot id: A0A8M2B865
uniprot id: A0A8M2B873
uniprot id: A0A8M3ALB2
uniprot id: A0A8M6YUH4
uniprot id: A0A8M6YWX8
uniprot id: A0A8M6Z304
uniprot id: A0A8M9P3D4
uniprot id: A0A8M9P3D7
uniprot id: A0A8M9P3E0
uniprot id: A0A8M9PCQ8
uniprot id: A0A8M9PCR3
uniprot id: A0A8M9PIC6
uniprot id: A0A8M9PIC9
uniprot id: A0A8M9PID2
uniprot id: A0A8M9PQI9
uniprot id: A0A8M9PQJ2
uniprot id: A0A8M9PQJ5
uniprot id: A0A8M9PTY8
uniprot id: A0A8M9PTZ2
uniprot id: A0A8M9PTZ9
uniprot id: F1QZT8
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

7955:tmem144a
gene id: 7955:tmem144a
uniprot id: A7YYD7
uniprot id: Q68EK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

7955:LOC108180717
gene id: 7955:LOC108180717
uniprot id: A0A8M6Z3Q9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:zmp:0000000711
gene id: 7955:zmp:0000000711
uniprot id: A0A8M2BBL9
uniprot id: A0A8M2BBP8
uniprot id: A0A8N7T7N1
uniprot id: F1R8G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

7955:si:dkey-91m3.1
gene id: 7955:si:dkey-91m3.1
uniprot id: A0A8M1RNP0
uniprot id: A0A8M3B6V8
uniprot id: E7F670
names: Similarity
messages: Belongs to the MDFI family.

7955:nkx3.3
gene id: 7955:nkx3.3
uniprot id: A0A8M1N4J4
uniprot id: F1R3M6
names: Subcellular Location Annotation
messages: Nucleus

7955:tppp3
gene id: 7955:tppp3
uniprot id: E7FG48
names: Similarity
messages: Belongs to the TPPP family.

7955:si:dkey-21h14.8
gene id: 7955:si:dkey-21h14.8
uniprot id: A0A8M9PHM5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:mrps18c
gene id: 7955:mrps18c
uniprot id: A4FVK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

7955:tmpob
gene id: 7955:tmpob
uniprot id: Q503J3
names: Similarity
messages: Belongs to the LEM family.

7955:hspb15
gene id: 7955:hspb15
uniprot id: A5JV84
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7955:cd247l
gene id: 7955:cd247l
uniprot id: A6Y958
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:cxcr5
gene id: 7955:cxcr5
uniprot id: A0A8M9PQZ3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:tmem229b
gene id: 7955:tmem229b
uniprot id: Q08CG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

7955:uspl1
gene id: 7955:uspl1
uniprot id: Q6DRC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cajal body
messages: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for sumo2 and sumo3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (By similarity). Is a component of complexes that can bind to U snRNA genes (By similarity).

7955:cep135
gene id: 7955:cep135
uniprot id: Q5RG45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP135/TSGA10 family.
messages: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity).
messages: centriole

7955:cant1a
gene id: 7955:cant1a
uniprot id: Q6NUZ5
names: Similarity
messages: Belongs to the apyrase family.

7955:gad1b
gene id: 7955:gad1b
uniprot id: A0A2R8QPB1
uniprot id: A0A8M3B331
uniprot id: Q7ZUS3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

7955:zgc:198371
gene id: 7955:zgc:198371
uniprot id: Q5GH39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:slc8a1a
gene id: 7955:slc8a1a
uniprot id: A0A8M2BGR5
uniprot id: A0A8M9QD34
uniprot id: A0A8M9QLM2
uniprot id: F1R4F4
uniprot id: Q32SG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

7955:tyms
gene id: 7955:tyms
uniprot id: Q6P045
names: Similarity
messages: Belongs to the thymidylate synthase family.

7955:fuz
gene id: 7955:fuz
uniprot id: A0A8M1PS70
uniprot id: E7F707
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

7955:tuba4l
gene id: 7955:tuba4l
uniprot id: Q6TGS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

7955:gsk3ab
gene id: 7955:gsk3ab
uniprot id: A0A8M3AQC2
uniprot id: Q6NZV8
uniprot id: Q9YH61
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

7955:adka
gene id: 7955:adka
uniprot id: A0A0R4IYX1
uniprot id: A0A8M1NZA9
uniprot id: Q6P3J9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

7955:mapkapk2a
gene id: 7955:mapkapk2a
uniprot id: Q7T2F2
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:paip2b
gene id: 7955:paip2b
uniprot id: Q6PBS9
names: Similarity
messages: Belongs to the PAIP2 family.

7955:ptdss2
gene id: 7955:ptdss2
uniprot id: E7EY42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity).
messages: Endoplasmic reticulum membrane

7955:cdc42ep3
gene id: 7955:cdc42ep3
uniprot id: Q66HU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

7955:cux1a
gene id: 7955:cux1a
uniprot id: A0A2R8Q0A5
uniprot id: A0A2R8QFA5
uniprot id: A0A8M1RNM7
uniprot id: A0A8M2BJW5
uniprot id: A0A8M2BJX8
uniprot id: A0A8M2BJZ7
uniprot id: A0A8M2BK19
uniprot id: A0A8M9Q6L3
uniprot id: A0A8M9QCL4
uniprot id: E7F4J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

7955:sigirr
gene id: 7955:sigirr
uniprot id: A0A140YX94
uniprot id: A0A8M3APR8
uniprot id: A4JYJ7
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

7955:LOC108183296
gene id: 7955:LOC108183296
uniprot id: A0A8M6Z618
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:ntrk2a
gene id: 7955:ntrk2a
uniprot id: A0A8M3AVL1
uniprot id: A0A8M3B589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:rin3
gene id: 7955:rin3
uniprot id: A0A8M1PZC2
uniprot id: E7FC22
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

7955:tmem14ca
gene id: 7955:tmem14ca
uniprot id: A0A2R8QK55
uniprot id: A0A8M2B9G8
uniprot id: Q0P436
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM14 family.
messages: Membrane
messages: Morpholino knockdown of the protein results in profound anemia without affecting erythroid specification.
messages: Required for normal heme biosynthesis.

7955:borcs5
gene id: 7955:borcs5
uniprot id: A0A2R8PVF5
uniprot id: A0A8M2B9Z4
uniprot id: Q5XIX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

7955:suv420h2
gene id: 7955:suv420h2
uniprot id: A5D6U3
names: Subcellular Location Annotation
messages: Nucleus

7955:tubb2b
gene id: 7955:tubb2b
uniprot id: A0A8M1N7Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:clvs2
gene id: 7955:clvs2
uniprot id: Q5SPP0
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Binding to PtdIns(3,5)P2 is not required for localization.
messages: Early endosome membrane
messages: Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).
messages: The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

7955:pdia3
gene id: 7955:pdia3
uniprot id: A0A8M1NXI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

7955:mt2
gene id: 7955:mt2
uniprot id: Q1LV07
uniprot id: Q7ZSY6
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: By zinc ions.
messages: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
messages: Expressed both maternally and zygotically. Expressed ubiquitously during early embryogenesis, but becomes localized to the tail region during segmentation. During early larval development, expressed in discrete areas including the pronephric region, retina and cerebellum.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

7955:myo1ea
gene id: 7955:myo1ea
uniprot id: A0A8M2BG72
uniprot id: A0A8M2BG81
uniprot id: A0A8N7TD18
uniprot id: E7FDV0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:si:ch211-66k16.28
gene id: 7955:si:ch211-66k16.28
uniprot id: A0A386CAB9
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as the sensor component of the nlrp1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis (PubMed:30150286). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:30150286). Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, and mediates the formation of the inflammasome polymeric complex (By similarity). In response to pathogen-associated signals, the N-terminal part of nlrp1 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the inflammasome recruits and activate pro-inflammatory caspases (caspa and/or caspb), leading to pyroptosis (By similarity).
messages: Autocatalytically cleaved. Autocatalytic cleavage in FIIND region occurs constitutively, prior to activation signals, and is required for inflammasome activity (IL1B release), possibly by facilitating pro-inflammatory caspases (caspa and/or caspb) binding. Both N- and C-terminal parts remain associated non-covalently.
messages: Belongs to the NLRP family.
messages: Constitutes the active part of the nlrp1 inflammasome (By similarity). In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of nlrp1 (NACHT, LRR and PYD domains-containing protein 1, N-terminus), preventing activation of the nlrp1 inflammasome (By similarity). In response to pathogen-associated signals, the N-terminal part of nlrp1 is degraded by the proteasome, releasing this form, which polymerizes to form the nlrp1 inflammasome complex: the nlrp1 inflammasome complex then directly recruits and activates pro-inflammatory caspases (caspa and/or caspb) activation, leading to subsequent pyroptosis (By similarity).
messages: Constitutes the precursor of the nlrp1 inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals.
messages: Cytoplasm
messages: Expressed in adult spleen, head kidney, gill and skin and also in the embryo.
messages: In the embryo, highest expression at 2 hours post-fertilization (hpf) with levels decreasing in later stages.
messages: Inflammasome
messages: Interacts with the C-terminal part of nlrp1 (NACHT, LRR and PYD domains-containing protein 1, C-terminus) in absence of pathogens and other damage-associated signals.
messages: Interacts with the N-terminal part of nlrp1 (NACHT, LRR and PYD domains-containing protein 1, N-terminus) in absence of pathogens and other damage-associated signals (By similarity). Homomultimer; forms the nlrp1 inflammasome polymeric complex, a filament composed of homopolymers of this form in response to pathogens and other damage-associated signals (By similarity). The nlrp1 inflammasome polymeric complex associates with pycard/asc (PubMed:30150286). Interacts (via CARD domain) with pycard/asc (via CARD domain); leading to pro-inflammatory caspases (caspa and/or caspb) recruitment (PubMed:30150286). Pro-caspase-a and pro-caspase-b filament formation increases local enzyme concentration, resulting in trans-autocleavage and activation. Active caspa and caspb then processes il1b and il18 precursors, leading to the release of mature cytokines in the extracellular milieu and inflammatory response (By similarity).
messages: Morpholino knockdown in embryos 6 hours post-fertilization (hpf) results in reduced caspa and caspb activation following bacterial infection with E.tarda.
messages: Regulatory part that prevents formation of the nlrp1 inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of nlrp1 (NACHT, LRR and PYD domains-containing protein 1, C-terminus), preventing activation of the nlrp1 inflammasome (By similarity). In response to pathogen-associated signals, this part is ubiquitinated and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the nlrp1 inflammasome (By similarity).
messages: The C-terminal part of nlrp1 oligomerizes to form the core of the nlrp1 inflammasome filament: in the filament, the CARD domains form a central helical filaments that are promoted by oligomerized, but flexibly linked, UPA regions surrounding the filaments.
messages: The CARD domain is involved in the interaction with pycard.
messages: Ubiquitinated in response to pathogen-associated signals, leading to its degradation by the proteasome and subsequent release of the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes and forms the nlrp1 inflammasome.
messages: Up-regulated in response to infection with the bacteriim E.tarda.
messages: nlrp1 inflammasome is activated by pathogens and other damage-associated signals: activation promotes ubiquitination and degradation of the N-terminal part, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes and forms the nlrp1 inflammasome.

7955:crp4
gene id: 7955:crp4
uniprot id: Q1RM11
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:hacd1
gene id: 7955:hacd1
uniprot id: A0A0G2L0Q2
uniprot id: A0A8M1P9G1
uniprot id: A0A8M2BE05
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:taar13d
gene id: 7955:taar13d
uniprot id: A0A8M1NCF5
uniprot id: Q5QNQ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:dpp4
gene id: 7955:dpp4
uniprot id: B5DDZ4
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane raft
messages: invadopodium membrane
messages: lamellipodium membrane

7955:crygn2
gene id: 7955:crygn2
uniprot id: Q6DGY7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Has a two-domain beta-structure, folded into four very similar Greek key motifs.
messages: Monomer.

7955:si:dkey-204a24.11
gene id: 7955:si:dkey-204a24.11
uniprot id: A0A8M3AVD6
uniprot id: I3IS45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:nadka
gene id: 7955:nadka
uniprot id: Q568T8
names: Similarity
messages: Belongs to the NAD kinase family.

7955:taar14e
gene id: 7955:taar14e
uniprot id: Q5RG95
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:rpl7l1
gene id: 7955:rpl7l1
uniprot id: Q6PFJ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

7955:enpep
gene id: 7955:enpep
uniprot id: A0A8M1NWG3
uniprot id: B8JIB4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.

7955:itga6a
gene id: 7955:itga6a
uniprot id: A0A8M2BER2
uniprot id: A0A8M2BFG1
uniprot id: A8WHQ7
uniprot id: A8WHQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:atl1
gene id: 7955:atl1
uniprot id: A0A8M1NQA6
uniprot id: A0A8M2B377
uniprot id: B8A6H1
uniprot id: E9QGX9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:atxn7l3
gene id: 7955:atxn7l3
uniprot id: A0A8M2BBE6
uniprot id: A1L209
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates in a subcomplex of SAGA called the DUB module (deubiquitination module) (By similarity).
messages: Component of some SAGA transcription coactivator-HAT complexes. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain forms part of the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

7955:adgrg7.1
gene id: 7955:adgrg7.1
uniprot id: A0A8M9PJW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:hapln3
gene id: 7955:hapln3
uniprot id: Q6NV41
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:spp2
gene id: 7955:spp2
uniprot id: A0A8M1P445
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

7955:gata5
gene id: 7955:gata5
uniprot id: Q9W6U0
names: Subcellular Location Annotation
messages: Nucleus

7955:ttll1
gene id: 7955:ttll1
uniprot id: A0A8M1P2G8
uniprot id: F8W385
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin polyglutamylase family.
messages: cilium basal body

7955:slc6a17
gene id: 7955:slc6a17
uniprot id: A0A8M1P4L1
uniprot id: X1WEE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:LOC100330650
gene id: 7955:LOC100330650
uniprot id: A0A2R8Q842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:si:dkey-56i24.1
gene id: 7955:si:dkey-56i24.1
uniprot id: A0A8M1NG64
uniprot id: B0V2Y5
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

7955:grm5a
gene id: 7955:grm5a
uniprot id: A0A8M3BCY8
uniprot id: U3N6H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7955:scube3
gene id: 7955:scube3
uniprot id: A0A8M9PKI0
uniprot id: A0A8N7XJH7
uniprot id: F1R0I7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:tgm5l
gene id: 7955:tgm5l
uniprot id: A0A0R4IGK8
uniprot id: A0A8M1P812
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

7955:nipsnap3a
gene id: 7955:nipsnap3a
uniprot id: A0A8M1PGX5
uniprot id: F1QWR0
names: Similarity
messages: Belongs to the NipSnap family.

7955:ms4a17a.4
gene id: 7955:ms4a17a.4
uniprot id: A0A8M1NED8
uniprot id: A0A8M3AZ55
uniprot id: F1QSM6
names: Similarity
messages: Belongs to the MS4A family.

7955:grhprb
gene id: 7955:grhprb
uniprot id: A0A8M2BFM8
uniprot id: E9QCX2
uniprot id: F1QYH7
uniprot id: Q6P0V7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

7955:naa38
gene id: 7955:naa38
uniprot id: A2BIG9
uniprot id: A7E284
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of naa35, naa38 and naa30.
messages: Cytoplasm

7955:tnmd
gene id: 7955:tnmd
uniprot id: A9JRD2
names: Similarity
messages: Belongs to the chondromodulin-1 family.

7955:gadd45aa
gene id: 7955:gadd45aa
uniprot id: A0A8M1PBG0
uniprot id: F1R8Z0
names: Similarity
messages: Belongs to the GADD45 family.

7955:ntn1a
gene id: 7955:ntn1a
uniprot id: A0A8M9QA53
uniprot id: O42140
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:clul1
gene id: 7955:clul1
uniprot id: A5PMY8
uniprot id: B7ZV05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Secreted

7955:itgb4
gene id: 7955:itgb4
uniprot id: A0A8M2BEB1
uniprot id: Q4U0S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

7955:fnta
gene id: 7955:fnta
uniprot id: A1L1V1
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

7955:got2a
gene id: 7955:got2a
uniprot id: Q7SYK7
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism.
messages: Cell membrane
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
messages: Mitochondrion matrix
messages: Morpholino knockdown of the protein results in brain developmental defects. Morphants show a small head and seizure-like electroencephalography spikes. Additional defects include slow circulation, bend body and pericardial edema.

7955:mon1ba
gene id: 7955:mon1ba
uniprot id: A0A8M9QE07
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

7955:ska2
gene id: 7955:ska2
uniprot id: A0A2R8QLG0
uniprot id: A0A8M1NVI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

7955:cdk20
gene id: 7955:cdk20
uniprot id: A0A8M3B1S0
uniprot id: A8WIP6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cytoplasm
messages: Fish lacking cdk20 are viable during embryogenesis and early larval stages, but exhibit curvature of the body axis and curled cilia in distal kidney tubules.
messages: Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.
messages: Monomer. Interacts with tbc1d32.
messages: Nucleus
messages: cilium

7955:rnaseh1
gene id: 7955:rnaseh1
uniprot id: A0A8M1N0V4
uniprot id: Q6DG94
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

7955:opn7a
gene id: 7955:opn7a
uniprot id: A0A8N7XJ79
uniprot id: F1RAF0
names: Subcellular Location Annotation
messages: Membrane

7955:tmem135
gene id: 7955:tmem135
uniprot id: A4QN71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM135 family.
messages: Membrane
messages: Peroxisome membrane

7955:twf2b
gene id: 7955:twf2b
uniprot id: A0A8M3B3Z6
uniprot id: E7F2D6
uniprot id: Q502J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

7955:bmp4
gene id: 7955:bmp4
uniprot id: O57574
names: Similarity
messages: Belongs to the TGF-beta family.

7955:nol11
gene id: 7955:nol11
uniprot id: Q4V9P9
names: Function
names: Subcellular Location Annotation
messages: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and pre-rRNA processing (By similarity).
messages: nucleolus

7955:sla1
gene id: 7955:sla1
uniprot id: Q3ZB94
names: Subcellular Location Annotation
messages: Cytoplasm

7955:gng7
gene id: 7955:gng7
uniprot id: Q6DGZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:hmgcl
gene id: 7955:hmgcl
uniprot id: Q7ZV32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

7955:im:7160594
gene id: 7955:im:7160594
uniprot id: A0A8M1RMT4
names: Subcellular Location Annotation
messages: Membrane

7955:rgmb
gene id: 7955:rgmb
uniprot id: Q6IYD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

7955:si:ch211-129c21.1
gene id: 7955:si:ch211-129c21.1
uniprot id: A0A8M1N9V0
uniprot id: A0A8M2BHS6
uniprot id: M9MMA2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:174356
gene id: 7955:zgc:174356
uniprot id: A0A8M1PAI1
uniprot id: E7F3C5
names: Subcellular Location Annotation
messages: Membrane

7955:pdp2
gene id: 7955:pdp2
uniprot id: Q32LW9
names: Similarity
messages: Belongs to the PP2C family.

7955:nol10
gene id: 7955:nol10
uniprot id: B2GQM3
uniprot id: Q802W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

7955:spra
gene id: 7955:spra
uniprot id: A0A8M1N6P5
uniprot id: F1QWX4
names: Similarity
messages: Belongs to the sepiapterin reductase family.

7955:psme4b
gene id: 7955:psme4b
uniprot id: A0A2R9YJG8
uniprot id: A0A8M1NW04
uniprot id: A0A8M2B325
uniprot id: F1QE31
names: Similarity
messages: Belongs to the BLM10 family.

7955:zgc:153675
gene id: 7955:zgc:153675
uniprot id: A0A8M2BFL5
uniprot id: Q08BH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

7955:tmem198b
gene id: 7955:tmem198b
uniprot id: A0A8M9QFG9
uniprot id: Q498W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

7955:asic1a
gene id: 7955:asic1a
uniprot id: A0A8M9QIQ3
uniprot id: B0R1B0
uniprot id: Q708S7
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.
messages: Cell membrane
messages: Channel opening involves a conformation change that affects primarily the extracellular domain and the second transmembrane helix and its orientation in the membrane. In the open state, the second transmembrane helix is nearly perpendicular to the plane of the membrane; in the desensitized state it is strongly tilted. Besides, the second transmembrane domain is discontinuously helical in the open state. The GAS motif of the selectivity filter is in an extended conformation, giving rise to a distinct kink in the polypeptide chain. A domain swap between subunits gives rise to a full-length transmembrane helix (By similarity).
messages: Expressed in central nervous system. Faintly expressed in the trunk, presumably in dorsal root ganglia.
messages: First detected 48 hours post-fertilization (hpf) in the ventral thalamus, ventral midbrain, ventral cerebellum, ventral hindbrain, dorsal thalamus, hypothalamus, telencephalon, along the tract of the anterior commissure. Weakly expressed in the dorsal midbrain and olfactory bulb. Expression increases by 96 hpf and is detected in the tectum and trunk.
messages: Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with asic1/accn2c.
messages: Inhibited by the diuretic amiloride.
messages: Membrane
messages: Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.

7955:nim1k
gene id: 7955:nim1k
uniprot id: E7F7X7
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:prom1a
gene id: 7955:prom1a
uniprot id: A0A0R4IE66
uniprot id: A0A0R4IHU7
uniprot id: A0A8M2B3M9
uniprot id: A0A8M2B446
uniprot id: A0A8M2B468
uniprot id: A0A8M3AI42
uniprot id: A0A8M3AS96
uniprot id: A0A8M9PZ24
uniprot id: A0A8M9QAU9
uniprot id: A0A8M9QAV3
uniprot id: A0A8M9QGA0
uniprot id: A0A8M9QGA5
uniprot id: A0A8M9QKH3
uniprot id: A0A8M9QP21
uniprot id: A0A8M9QP25
uniprot id: H7BWW9
uniprot id: Q9W735
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the prominin family.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. Involved in regulation of MAPK and Akt signaling pathways (By similarity).
messages: Membrane
messages: microvillus membrane

7955:cog8
gene id: 7955:cog8
uniprot id: Q5BLI1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

7955:esyt1a
gene id: 7955:esyt1a
uniprot id: A0A8N7T801
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:tcf12
gene id: 7955:tcf12
uniprot id: A0A0R4IBL7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Morpholino lockdown of the gene in 2 days post-fertilization (dpf) larvae show a dose-dependent significant reduction in the length of the terminal nerve axons, which provide the scaffold for migrating GnRH neurons towards the hypothalamus. In addition, there is a significant reduction in the size of the olfactory bulb.
messages: Nucleus
messages: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954).

7955:si:ch211-269c21.2
gene id: 7955:si:ch211-269c21.2
uniprot id: A0A8M3B780
uniprot id: F1RAR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:rx2
gene id: 7955:rx2
uniprot id: F1QNV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus
messages: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.

7955:sybl1
gene id: 7955:sybl1
uniprot id: E9QC42
uniprot id: Q7ZUI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

7955:sult3st3
gene id: 7955:sult3st3
uniprot id: H9AWE3
uniprot id: Q1L872
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:med19a
gene id: 7955:med19a
uniprot id: Q08C81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:gbgt1l3
gene id: 7955:gbgt1l3
uniprot id: A0A8M9PJY0
uniprot id: A0A8M9QDS3
uniprot id: Q66IC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

7955:pkib
gene id: 7955:pkib
uniprot id: A0A8M1NG02
uniprot id: Q5SPN9
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

7955:wdr81
gene id: 7955:wdr81
uniprot id: E7FEV0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the WD repeat WDR81 family.
messages: Early endosome membrane
messages: Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. May also be involved in maintenance of normal mitochondrial structure and organization.
messages: Highly expressed at 5 and 15 hpf. Expression is higher in brain and eye. The expression drops after 72 hpf.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Mitochondrion
messages: Widely expressed.
messages: autophagosome membrane
messages: cytosol

7955:clic2
gene id: 7955:clic2
uniprot id: Q6DGV0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

7955:grem2a
gene id: 7955:grem2a
uniprot id: A0A8M2B538
uniprot id: F1R4W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

7955:rgs12b
gene id: 7955:rgs12b
uniprot id: A0A8M3AU63
uniprot id: A0A8M3B2C1
uniprot id: Q6T9C1
uniprot id: Q6T9C2
uniprot id: Q6T9C3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: dendrite

7955:gna15.1
gene id: 7955:gna15.1
uniprot id: A0A8M2BHS4
uniprot id: A0A8M2BHS9
uniprot id: F1QJL5
uniprot id: Q6DEH5
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

7955:slc6a13
gene id: 7955:slc6a13
uniprot id: A0A8M2BDD5
uniprot id: Q801U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:ins
gene id: 7955:ins
uniprot id: B2GSI0
uniprot id: O73727
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

7955:zgc:114130
gene id: 7955:zgc:114130
uniprot id: A0A8M2BKP1
uniprot id: F1QH59
uniprot id: Q4V8V0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

7955:map4k6
gene id: 7955:map4k6
uniprot id: A0A8M2B8G6
uniprot id: A0A8M9PU24
uniprot id: B2GSZ8
uniprot id: Q1JQ22
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

7955:kcna4
gene id: 7955:kcna4
uniprot id: F1Q929
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

7955:vldlr
gene id: 7955:vldlr
uniprot id: A0A0R4IGN2
uniprot id: A0A8M1PDP0
uniprot id: A0A8M2B1M8
uniprot id: A0A8M2B226
uniprot id: A0A8M2B2A5
uniprot id: A0A8M2B2G0
uniprot id: A0A8M9PTE7
uniprot id: E7FF13
uniprot id: E9QBA5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: clathrin-coated pit

7955:dmrt3a
gene id: 7955:dmrt3a
uniprot id: P83758
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DMRT family.
messages: Expressed in the developing germ cells of both gonads, mainly in spermatogonia, spermatocytes and developing oocytes. Also expressed in embryonic olfactory placode and neural tube.
messages: Expression increases gradually to a high level at pharyngula stage, which is restricted to the olfactory placode and the neural tube. In the juvenile zebrafish, the expression is first detected in undifferentiated gonad on 17 dpf.
messages: Nucleus
messages: Probable transcription factor that plays a role in configuring the spinal circuits controlling motion in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling movements. May regulate transcription (By similarity).

7955:tpm4a
gene id: 7955:tpm4a
uniprot id: A0A8M6YUW1
uniprot id: A0A8M6Z3C6
uniprot id: F1R412
uniprot id: Q5U3J6
uniprot id: Q7T3F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

7955:eif4e2
gene id: 7955:eif4e2
uniprot id: A1L200
uniprot id: B2GPF6
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

7955:mrps5
gene id: 7955:mrps5
uniprot id: Q08C39
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

7955:tegt
gene id: 7955:tegt
uniprot id: A0A140LGF6
uniprot id: A0A8M1RKH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7955:gra
gene id: 7955:gra
uniprot id: B3DKF4
uniprot id: B3DKG4
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

7955:si:ch211-160j14.2
gene id: 7955:si:ch211-160j14.2
uniprot id: A0A8M1PU48
uniprot id: E7F2I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

7955:ND2
gene id: 7955:ND2
uniprot id: A0A0A0V9A1
uniprot id: Q9MIY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

7955:rnaset2
gene id: 7955:rnaset2
uniprot id: A0A8M9PY62
uniprot id: B8XY56
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: AO127 mutants were identified based on increased acridine orange uptake. AO127 mutants display enlarged lysosomes in brain and lysosomal accumulation of undigested ribosomal RNA in brain neurons, white matter lesions adjacent to brain ventricles, and frequent focal white matter anomalies throughout the brain. Nevertheless, mutants appear basically normal, reach normal adult size and length, are fertile and do not display obvious gross motor deficiencies.
messages: Belongs to the RNase T2 family.
messages: Endoplasmic reticulum lumen
messages: Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA.
messages: Lysosome lumen
messages: Secreted
messages: Ubiquitous.

7955:si:dkey-10o6.2
gene id: 7955:si:dkey-10o6.2
uniprot id: A0A8M9P9V2
uniprot id: A7E280
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

7955:agrp
gene id: 7955:agrp
uniprot id: A0A2R8QM92
uniprot id: A0A8M1P467
names: Subcellular Location Annotation
messages: Secreted

7955:actn3a
gene id: 7955:actn3a
uniprot id: Q7SYD3
names: Similarity
messages: Belongs to the alpha-actinin family.

7955:fbln5
gene id: 7955:fbln5
uniprot id: A0A8M2B2Z6
uniprot id: B8A4X3
uniprot id: Q5XJ74
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:sox12
gene id: 7955:sox12
uniprot id: A0A8M1N7K3
uniprot id: Q7SZW4
names: Subcellular Location Annotation
messages: Nucleus

7955:kcnj16
gene id: 7955:kcnj16
uniprot id: A0A8M3B7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:pimr83
gene id: 7955:pimr83
uniprot id: A0A8M9PSE7
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

7955:LOC100334116
gene id: 7955:LOC100334116
uniprot id: A0A8M3AUS6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

7955:exd1
gene id: 7955:exd1
uniprot id: Q0P3U3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXD1 family.
messages: Cytoplasm
messages: Homodimer (By similarity). Component of the PET complex (By similarity).
messages: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the piwil2 slicing-triggered loading of piwil4 piRNAs. In the PET complex, exd1 probably acts as an RNA adapter. Exd1 is an inactive exonuclease.
messages: The 3'-5' exonuclease domain lacks the conserved Asp-Glu-Asp-Asp (DEDD) residues that coordinates divalent ions essential for exonuclease activity.

7955:baxb
gene id: 7955:baxb
uniprot id: Q5EAR7
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:osxm
gene id: 7955:osxm
uniprot id: A0A8N7TE41
uniprot id: F1R7W6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

7955:fut9d
gene id: 7955:fut9d
uniprot id: Q2VU44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

7955:cnksr2b
gene id: 7955:cnksr2b
uniprot id: A0A8M3AM98
uniprot id: A0A8N7UV27
uniprot id: E7FAZ0
names: Similarity
messages: Belongs to the CNKSR family.

7955:mynn
gene id: 7955:mynn
uniprot id: A0A8M2B9Q5
uniprot id: Q7ZVR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

7955:il1b
gene id: 7955:il1b
uniprot id: A0A8M1PI54
uniprot id: E6N152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Lysosome
messages: cytosol
messages: extracellular exosome

7955:si:ch1073-296d18.1
gene id: 7955:si:ch1073-296d18.1
uniprot id: A0A8M9PNZ8
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:arf2b
gene id: 7955:arf2b
uniprot id: Q7ZUZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

7955:ca7
gene id: 7955:ca7
uniprot id: Q6PBI7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:selj
gene id: 7955:selj
uniprot id: A0A8M1NUZ2
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

7955:timmdc1
gene id: 7955:timmdc1
uniprot id: Q568N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the intermediate 315 kDa subcomplex of incompletely assembled complex I.
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity).
messages: Mitochondrion membrane

7955:e4f1
gene id: 7955:e4f1
uniprot id: Q4V8R6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May function as a transcriptional repressor. May also function as a ubiquitin ligase. Functions in cell survival and proliferation through control of the cell cycle.
messages: nucleoplasm

7955:si:dkey-44g17.6
gene id: 7955:si:dkey-44g17.6
uniprot id: A0A0R4IHM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:sgsm2
gene id: 7955:sgsm2
uniprot id: A0A8M9PCC5
uniprot id: A0A8M9PNK7
names: Similarity
messages: Belongs to the RUTBC family.

7955:scoca
gene id: 7955:scoca
uniprot id: A0A8M2B6W3
uniprot id: B8A5C7
uniprot id: Q08BG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Golgi apparatus membrane
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: cytosol
messages: trans-Golgi network

7955:pde6c
gene id: 7955:pde6c
uniprot id: Q6P4P8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:stum
gene id: 7955:stum
uniprot id: A0A8M2B7P8
uniprot id: Q5TYP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPEC3 family. Stum subfamily.
messages: Membrane

7955:smad7
gene id: 7955:smad7
uniprot id: Q6NZT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

7955:LOC110438115
gene id: 7955:LOC110438115
uniprot id: A0A8M9P1L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

7955:zgc:101785
gene id: 7955:zgc:101785
uniprot id: Q5XJM0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

7955:pnpla6
gene id: 7955:pnpla6
uniprot id: A0A8M1QHJ2
uniprot id: A0A8M2B6R2
uniprot id: A0A8M2B788
uniprot id: F1R844
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ppat
gene id: 7955:ppat
uniprot id: A6H8S4
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

7955:rpl9
gene id: 7955:rpl9
uniprot id: Q5BKV9
uniprot id: Q6DRM3
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

7955:zgc:172271
gene id: 7955:zgc:172271
uniprot id: A9JRF6
uniprot id: F1R9Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.

7955:rraga
gene id: 7955:rraga
uniprot id: Q7ZUI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

7955:metrnl
gene id: 7955:metrnl
uniprot id: Q7ZV46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the meteorin family.
messages: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance (By similarity).
messages: Secreted

7955:slc25a11
gene id: 7955:slc25a11
uniprot id: Q6IQ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:or127-1
gene id: 7955:or127-1
uniprot id: Q2PRG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:npl
gene id: 7955:npl
uniprot id: A9C3P6
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Homotetramer.

7955:slc5a3a
gene id: 7955:slc5a3a
uniprot id: A0A8M1NUB8
uniprot id: B8JHU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7955:rbck1
gene id: 7955:rbck1
uniprot id: Q6GMF9
names: Similarity
messages: Belongs to the RBR family.

7955:nek6
gene id: 7955:nek6
uniprot id: A0A8M1RFQ9
uniprot id: A0A8M9PUE6
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:cul5b
gene id: 7955:cul5b
uniprot id: A0A0R4IGP7
uniprot id: A0A8M1QHT0
uniprot id: A0A8M2B8G3
uniprot id: A0A8M3ALI0
uniprot id: A0A8M3ATW9
uniprot id: A0A8M3B4Q9
uniprot id: F1QFY1
names: Similarity
messages: Belongs to the cullin family.

7955:pimr175
gene id: 7955:pimr175
uniprot id: A0A8M6YVP1
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:fam114a1
gene id: 7955:fam114a1
uniprot id: A0A8M3B814
uniprot id: A4QNX7
names: Similarity
messages: Belongs to the FAM114 family.

7955:vti1a
gene id: 7955:vti1a
uniprot id: A0A2R8Q5I2
uniprot id: A0A8M1P1X6
uniprot id: A0A8M2B2E0
uniprot id: A0A8M3BE99
uniprot id: A0A8M6Z1C2
uniprot id: F1Q7S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

7955:LOC100148704
gene id: 7955:LOC100148704
uniprot id: A0A8M1QL83
uniprot id: A0A8M3B2Y7
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:nmur1b
gene id: 7955:nmur1b
uniprot id: A0A8N7URE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

7955:thoc5
gene id: 7955:thoc5
uniprot id: A0A2R8QR48
uniprot id: A0A8M2BLG8
uniprot id: A0A8M9PGQ7
uniprot id: Q6NY52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
messages: Belongs to the THOC5 family.
messages: Component of the THO subcomplex of the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
messages: Cytoplasm
messages: May be involved in cell differentiation.
messages: Nucleus
messages: Nucleus speckle

7955:fmnl2a
gene id: 7955:fmnl2a
uniprot id: A0A8M1PSZ4
uniprot id: A0A8M2BFF3
uniprot id: A0A8M3B5D9
uniprot id: A0A8M6Z0B9
uniprot id: A0A8M6Z0Z8
uniprot id: A0A8M6Z2M2
uniprot id: A0A8M6Z832
uniprot id: F1QDA5
uniprot id: F1QKR1
names: Similarity
messages: Belongs to the formin homology family.

7955:zgc:110782
gene id: 7955:zgc:110782
uniprot id: Q5BLA6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

7955:si:ch211-168k14.2
gene id: 7955:si:ch211-168k14.2
uniprot id: A0A8M6Z0H6
uniprot id: A0A8M6Z873
uniprot id: A0A8M9Q566
names: Similarity
messages: Belongs to the phospholipase D family.

7955:rgs9bp
gene id: 7955:rgs9bp
uniprot id: A0A8M1P9J8
uniprot id: E7EYT5
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

7955:nap1l4b
gene id: 7955:nap1l4b
uniprot id: A0A8M3B448
uniprot id: A0A8M9PNW3
uniprot id: Q5U3U9
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7955:adgre10
gene id: 7955:adgre10
uniprot id: A0A8M9QD97
names: Subcellular Location Annotation
messages: Membrane

7955:ptx3a
gene id: 7955:ptx3a
uniprot id: A0A8M2B5R1
uniprot id: A3KPN4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:grin2aa
gene id: 7955:grin2aa
uniprot id: A0A8M9PXD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

7955:actr1
gene id: 7955:actr1
uniprot id: Q7ZUZ2
names: Similarity
messages: Belongs to the actin family.

7955:LOC110438807
gene id: 7955:LOC110438807
uniprot id: A0A8M9Q2U0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:mcm8
gene id: 7955:mcm8
uniprot id: A0A8M1RMD5
uniprot id: A0A8M9P0B2
uniprot id: E7F643
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

7955:cadm1b
gene id: 7955:cadm1b
uniprot id: B0F6R1
names: Similarity
messages: Belongs to the nectin family.

7955:atrnl1b
gene id: 7955:atrnl1b
uniprot id: A0A8N7UTF5
uniprot id: E7F6C7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:bcar1
gene id: 7955:bcar1
uniprot id: A0A2R8Q9D0
uniprot id: A0A2R8QJQ5
uniprot id: A0A8M2B5Q8
uniprot id: A0A8M2B621
uniprot id: A0A8M9PM80
uniprot id: B5DE36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

7955:si:ch211-261n11.7
gene id: 7955:si:ch211-261n11.7
uniprot id: A0A8M1RM46
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rell1
gene id: 7955:rell1
uniprot id: A0A8M1P1M1
uniprot id: F1QK31
names: Similarity
messages: Belongs to the RELT family.

7955:ehd3
gene id: 7955:ehd3
uniprot id: A0A8N7UY98
uniprot id: Q5TYP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

7955:riox1
gene id: 7955:riox1
uniprot id: A3KP59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROX family. NO66 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes demethylation of non-histone proteins (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity).
messages: nucleolus
messages: nucleoplasm

7955:sema3e
gene id: 7955:sema3e
uniprot id: A0A8M1N9X0
uniprot id: A0A8M9PQA6
uniprot id: Q1LYS1
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:fam131a
gene id: 7955:fam131a
uniprot id: A0A8M2BAH0
uniprot id: A0A8M3APL4
uniprot id: A0A8M9QE61
uniprot id: A9JRG1
names: Similarity
messages: Belongs to the FAM131 family.

7955:alox5b.1
gene id: 7955:alox5b.1
uniprot id: A0A8M6YUZ0
names: Caution
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cxcl11.1
gene id: 7955:cxcl11.1
uniprot id: A0A0R4INB9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Ligand for cxcr3.2. Chemotactic for macrophages.
messages: Secreted
messages: Up-regulated in response to bacterial infection by S.typhimurium or M.marinum.

7955:ccdc115
gene id: 7955:ccdc115
uniprot id: Q5EAR6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the multisubunit proton-transporting vacuolar (V)-ATPase protein pump.
messages: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. May be involved in Golgi homeostasis.
messages: COPI-coated vesicle
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Endosome
messages: Lysosome

7955:slc39a14
gene id: 7955:slc39a14
uniprot id: A0A0G2KQY6
uniprot id: A0A2R8Q9W7
uniprot id: A0A8M2BJ33
uniprot id: A0A8M9Q926
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.
messages: Cell membrane
messages: Early endosome membrane
messages: Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:27231142). Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity).
messages: Embryos with CRISPR-induced slc39a14 null mutations display altered manganese homeostasis. This is associated with manganese deposition in the brain and altered locomotor activity. Mutants survived into adulthood without any obvious morphological or developmental defects.
messages: Expressed at all stages of embryonic and early larval development.
messages: Homotrimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

7955:edc3
gene id: 7955:edc3
uniprot id: A0A8M2BA31
uniprot id: A0A8M2BAE2
uniprot id: F1QL27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

7955:grk7a
gene id: 7955:grk7a
uniprot id: Q49HM9
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
messages: Impaired cone response recovery and delayed dark adaptation.
messages: Membrane
messages: Phosphorylation at Ser-33 is regulated by light and activated by cAMP.
messages: Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

7955:lmbrd2b
gene id: 7955:lmbrd2b
uniprot id: Q6P4P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: May associate with G-protein coupled receptors and regulate downstream signaling pathways.

7955:si:ch211-269e2.1
gene id: 7955:si:ch211-269e2.1
uniprot id: A0A8M6Z159
uniprot id: B0S5T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

7955:tuba1a
gene id: 7955:tuba1a
uniprot id: Q6NWK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

7955:LOC571912
gene id: 7955:LOC571912
uniprot id: A0A8M1NWL8
uniprot id: A0A8M2B4Y9
uniprot id: F1QWD1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

7955:slco4a1
gene id: 7955:slco4a1
uniprot id: A0A0G3Y3D1
uniprot id: A0A8N7T6M8
uniprot id: E7FFX7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ikbke
gene id: 7955:ikbke
uniprot id: F1QBC9
uniprot id: Q6DGE5
names: Subcellular Location Annotation
messages: Cytoplasm

7955:fgf12a
gene id: 7955:fgf12a
uniprot id: A0A8M2BA97
uniprot id: A0A8M2BAD4
uniprot id: A0A8M2BAF2
uniprot id: A0AUQ1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7955:slc25a6
gene id: 7955:slc25a6
uniprot id: B0S730
uniprot id: B3DHI8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

7955:phox2ba
gene id: 7955:phox2ba
uniprot id: A0A8N7UZA0
uniprot id: B8A4X8
names: Subcellular Location Annotation
messages: Nucleus

7955:adprhl2
gene id: 7955:adprhl2
uniprot id: A0A8M3ARH3
uniprot id: Q66HT8
names: Activity Regulation
names: Cofactor
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (By similarity). Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
messages: Belongs to the ADP-ribosylglycohydrolase family.
messages: Binds 2 magnesium ions per subunit.
messages: Chromosome
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: The protein undergoes a dramatic conformational switch from closed to open states upon substrate-binding, which enables specific substrate recognition for the 1''-O-linkage. The glutamate flap (Glu-35) blocks substrate entrance to Mg(2+) in the unliganded closed state. In presence of substrate, Glu-35 is ejected from the active site: this closed-to-open transition significantly widens the substrate-binding channel and precisely positions the scissile 1''-O-linkage for cleavage while securing tightly 2'- and 3'-hydroxyls of ADP-ribose.
messages: Unlikely isoform. Aberrant splice sites.

7955:ift20
gene id: 7955:ift20
uniprot id: A0A0R4I9H0
uniprot id: B2GRJ4
uniprot id: Q66I67
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus
messages: Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella.
messages: acrosome
messages: centriole
messages: cilium
messages: cis-Golgi network

7955:foxb2
gene id: 7955:foxb2
uniprot id: A0A8M2B9C8
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC110438343
gene id: 7955:LOC110438343
uniprot id: A0A8M9P609
names: Function
messages: Cadherins are calcium-dependent cell adhesion proteins.

7955:nr5a2
gene id: 7955:nr5a2
uniprot id: A0A8M3AXL9
uniprot id: B3DJL1
uniprot id: Q90YL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

7955:kcnh6a
gene id: 7955:kcnh6a
uniprot id: A0A8M2BBB6
uniprot id: A0A8M2BBD6
uniprot id: A0A8M3AQY1
uniprot id: Q8JH78
names: Subcellular Location Annotation
messages: Membrane

7955:pomt2
gene id: 7955:pomt2
uniprot id: F1Q8R9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 39 family.
messages: Detected throughout development (PubMed:18632251, PubMed:20466645). Highest expression levels are found at 0 hours post-fertilization (hpf), probably due to perdurance of maternal transcripts (PubMed:20466645). Expression levels remain high at 6 hpf and decrease rapidly by 12 hpf, followed by a second moderate peak in expression at 24 hpf (PubMed:20466645). Ubiquitously expressed during early stages of development (PubMed:18632251, PubMed:20466645). At 16-24 hpf, mainly found in eye, brain and somites (PubMed:18632251, PubMed:20466645). At 30 hpf, has strongest expression in forebrain, cerebellum and hindbrain (PubMed:18632251).
messages: Endoplasmic reticulum membrane
messages: Morpholino knockdown of the protein results in developmental delays at 18 hours post fertilization (hpf). At 48-72 hpf the tail is abnormally twisted, and pericardium formation and eye pigmentation are also abnormal. Swim bladders are incompletely formed. Glycosylation of alpha-dystroglycan (dag1) is severely reduced.
messages: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.
messages: Widely expressed. Has particularly strong expression in ovary, testis, liver, brain, muscle, heart and eye.

7955:LOC558704
gene id: 7955:LOC558704
uniprot id: A0A8M9PRF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

7955:zgc:114041
gene id: 7955:zgc:114041
uniprot id: Q4KM10
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:114119
gene id: 7955:zgc:114119
uniprot id: Q4V8V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

7955:si:ch211-51i16.1
gene id: 7955:si:ch211-51i16.1
uniprot id: A0A8M9PSD6
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:si:dkey-261m9.11
gene id: 7955:si:dkey-261m9.11
uniprot id: E7EXD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:asic1c
gene id: 7955:asic1c
uniprot id: A0A8M6Z4P3
uniprot id: A0A8M9P5T7
uniprot id: A0A8M9PFW9
uniprot id: A0A8M9PLN1
uniprot id: A0A8M9PXD2
uniprot id: Q708S6
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.
messages: Cell membrane
messages: Channel opening involves a conformation change that affects primarily the extracellular domain and the second transmembrane helix and its orientation in the membrane. In the open state, the second transmembrane helix is nearly perpendicular to the plane of the membrane; in the desensitized state it is strongly tilted. Besides, the second transmembrane domain is discontinuously helical in the open state. The GAS motif of the selectivity filter is in an extended conformation, giving rise to a distinct kink in the polypeptide chain. A domain swap between subunits gives rise to a full-length transmembrane helix (By similarity).
messages: Expressed 30 hours post-fertilization (hpf) in the anterior and posterior lateral line ganglia where it persisted until at least 48 hpf. Also expressed between 30 and 72 hpf in the telencephalon. Expressed in the ventral thalamus, ventral midbrain, ventral cerebellum, and ventral hindbrain from 30 hpf. By 48 hpf, expressed also in the dorsal thalamus and hypothalamus. At 72 hpf, weak expression was apparent in the habenulae.
messages: Expressed in central nervous system.
messages: Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with ASIC1/ACCN2B.
messages: Inhibited by the diuretic amiloride.
messages: Membrane
messages: Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions.

7955:ntng2b
gene id: 7955:ntng2b
uniprot id: A0A8M3ALV5
uniprot id: A0A8M3AWK1
uniprot id: A0A8M6YUS3
uniprot id: A0A8M9P3I8
uniprot id: A0A8M9PIL9
uniprot id: A0A8M9PQS8
uniprot id: A0A8M9PUB1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tpra1
gene id: 7955:tpra1
uniprot id: Q4V8X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

7955:rtel1
gene id: 7955:rtel1
uniprot id: A0A8N7UY60
uniprot id: F1QNW3
uniprot id: P0C928
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:or106-3
gene id: 7955:or106-3
uniprot id: Q2PRL4
names: Subcellular Location Annotation
messages: Membrane

7955:trmt1l
gene id: 7955:trmt1l
uniprot id: A0A8N7TEL4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

7955:LOC101884238
gene id: 7955:LOC101884238
uniprot id: A0A8M9PKH3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:htr1aa
gene id: 7955:htr1aa
uniprot id: A0A8M1NIJ6
uniprot id: B0S6X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:abcc4
gene id: 7955:abcc4
uniprot id: Q8QFL6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Recycling endosome membrane

7955:calca
gene id: 7955:calca
uniprot id: F1QIK6
uniprot id: Q6DGJ9
names: Function
names: Similarity
messages: Belongs to the calcitonin family.
messages: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

7955:cops8
gene id: 7955:cops8
uniprot id: Q7ZUZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN8 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Cytoplasm
messages: Nucleus

7955:hnf1a
gene id: 7955:hnf1a
uniprot id: Q8UVH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

7955:tcea1
gene id: 7955:tcea1
uniprot id: B2GQI6
uniprot id: Q7T3C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

7955:heg1
gene id: 7955:heg1
uniprot id: A9C3V5
uniprot id: B3DFN7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:srfbp1
gene id: 7955:srfbp1
uniprot id: Q6DI30
names: Function
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

7955:tspan18a
gene id: 7955:tspan18a
uniprot id: A0A8M2BK40
uniprot id: A0A8M9QBT2
uniprot id: F1QI47
uniprot id: Q6DGC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:six4b
gene id: 7955:six4b
uniprot id: Q9DEE7
names: Subcellular Location Annotation
messages: Nucleus

7955:six2b
gene id: 7955:six2b
uniprot id: B3DIJ7
uniprot id: B3DIK2
names: Subcellular Location Annotation
messages: Nucleus

7955:prps1b
gene id: 7955:prps1b
uniprot id: Q08CA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

7955:midn
gene id: 7955:midn
uniprot id: A0A8M2BHR6
uniprot id: A0A8M2BHR8
uniprot id: Q6NYU6
names: Function
names: Subcellular Location Annotation
messages: Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
messages: Nucleus
messages: cytosol
messages: nucleolus

7955:wdpcp
gene id: 7955:wdpcp
uniprot id: A0A8M2B4W8
uniprot id: E7F9Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat fritz family.
messages: Cell membrane
messages: Membrane
messages: cilium axoneme

7955:ggh
gene id: 7955:ggh
uniprot id: A0A8M9PNR0
uniprot id: Q6NY42
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular space

7955:apoa1bp
gene id: 7955:apoa1bp
uniprot id: Q6DHK1
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homodimer (By similarity). Interacts with APOA1 (PubMed:23719382). Binds to HDL (PubMed:23719382).
messages: Mitochondrion
messages: Mutants do not show increased levels of free (unesterified) cholesterol.
messages: Secreted

7955:rxfp3.3a2
gene id: 7955:rxfp3.3a2
uniprot id: A0A8M1QKJ3
uniprot id: F1QMQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:ciao1
gene id: 7955:ciao1
uniprot id: Q6P0D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins.

7955:efr3bb
gene id: 7955:efr3bb
uniprot id: Q5SPP5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EFR3 family.
messages: Cell membrane
messages: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, efr3b probably acts as the membrane-anchoring component.
messages: Component of a phosphatidylinositol 4-kinase (PI4K) complex.
messages: Palmitoylated at its N-terminus, anchoring the protein to the plasma membrane.

7955:tmem97
gene id: 7955:tmem97
uniprot id: A0A8M1P2L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Endoplasmic reticulum membrane
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

7955:dhrs11a
gene id: 7955:dhrs11a
uniprot id: A0A8M1NF86
uniprot id: A5WUM7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:si:ch211-158d24.2
gene id: 7955:si:ch211-158d24.2
uniprot id: A0A8N7TEX5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:mettl20
gene id: 7955:mettl20
uniprot id: A3KP85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. ETFBKMT family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain.

7955:nedd8
gene id: 7955:nedd8
uniprot id: A0A8M1PFY0
uniprot id: F1QMF9
names: Similarity
messages: Belongs to the ubiquitin family.

7955:fgf24
gene id: 7955:fgf24
uniprot id: A0A8M3AZL7
uniprot id: Q0IIQ7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7955:nat9
gene id: 7955:nat9
uniprot id: A0A8M1P3E7
uniprot id: F1R8Q4
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

7955:cfh
gene id: 7955:cfh
uniprot id: E2FHP4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:clca1
gene id: 7955:clca1
uniprot id: A0A8M1P6E2
uniprot id: X1WHI8
names: Similarity
messages: Belongs to the CLCR family.

7955:cldnb
gene id: 7955:cldnb
uniprot id: B2GNJ5
uniprot id: Q90XR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:tekt3
gene id: 7955:tekt3
uniprot id: E7F7G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

7955:zranb1b
gene id: 7955:zranb1b
uniprot id: A0JMQ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C64 family.
messages: Cytoplasm
messages: Nucleus
messages: The OTU domain mediates the deubiquitinating activity.
messages: The RanBP2-type zinc fingers, also called NZFs, mediate the interaction with ubiquitin and determine linkage specificity. RanBP2-type zinc fingers 1 and 2 (also named NZF1 and NZF2) specifically recognize and bind 'Lys-29'- and 'Lys-33'-linked ubiquitin. RanBP2-type zinc finger 3 (also named NZF3) binds 'Lys-33'-linked ubiquitin and shows weak binding to 'Lys-6'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin chains but it does not interact with 'Lys-29'-linked chains.
messages: The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity.
messages: Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (By similarity). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (By similarity). Positive regulator of the Wnt signaling pathway that deubiquitinates apc protein, a negative regulator of Wnt-mediated transcription (By similarity). Acts as a regulator of autophagy by mediating deubiquitination of pik3c3/vps34, thereby promoting autophagosome maturation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required in the stress fiber dynamics and cell migration (By similarity).

7955:bxdc2
gene id: 7955:bxdc2
uniprot id: A0A0R4IBJ2
uniprot id: A0A8M1NVZ7
uniprot id: Q7SZR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

7955:prr5b
gene id: 7955:prr5b
uniprot id: A0A8M1RP29
uniprot id: A0A8M2BFT3
uniprot id: A0A8M6YY64
names: Similarity
messages: Belongs to the PROTOR family.

7955:LOC110440062
gene id: 7955:LOC110440062
uniprot id: A0A8M9QGT5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rab3c
gene id: 7955:rab3c
uniprot id: A0A8M2BEV5
uniprot id: A8WHV3
uniprot id: Q6DGH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

7955:foxf2b
gene id: 7955:foxf2b
uniprot id: A0A8M1RJD4
uniprot id: E7FER3
names: Subcellular Location Annotation
messages: Nucleus

7955:llgl1
gene id: 7955:llgl1
uniprot id: A0A8M2BBA4
uniprot id: A0A8M2BBF6
uniprot id: A0A8M9PXW4
uniprot id: E7FD67
uniprot id: I0BWE2
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

7955:mxra8a
gene id: 7955:mxra8a
uniprot id: A0A8M3BDP1
uniprot id: A0A8M9QD55
uniprot id: A1L1V2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:rabep1
gene id: 7955:rabep1
uniprot id: A0A8M2BJA3
uniprot id: B2BWH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Cytoplasm
messages: Early endosome
messages: Endosome

7955:crb1
gene id: 7955:crb1
uniprot id: A0A8M2B8L0
uniprot id: Q1A5L3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:atxn10
gene id: 7955:atxn10
uniprot id: B3DJT3
names: Function
names: Similarity
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.

7955:hbae3
gene id: 7955:hbae3
uniprot id: Q6IQA3
uniprot id: Q7ZYZ4
names: Similarity
messages: Belongs to the globin family.

7955:LOC110438377
gene id: 7955:LOC110438377
uniprot id: A0A8M9P6K9
names: Subcellular Location Annotation
messages: Nucleus

7955:si:ch211-218c6.8
gene id: 7955:si:ch211-218c6.8
uniprot id: A0A8M1PS84
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:LOC110437707
gene id: 7955:LOC110437707
uniprot id: A0A8M9PV01
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:smarcd3a
gene id: 7955:smarcd3a
uniprot id: A0A8M2BAN6
uniprot id: A0A8M2BAN7
uniprot id: A0A8M2BAQ8
uniprot id: A0A8M2BAR7
uniprot id: A0A8M2BAW1
uniprot id: A0A8M2BB18
uniprot id: E9QC50
names: Similarity
messages: Belongs to the SMARCD family.

7955:lrrfip2
gene id: 7955:lrrfip2
uniprot id: A0A0R4IMS4
uniprot id: A0A8M1N7T5
uniprot id: A0A8M2BGT5
uniprot id: A0A8M2BGV2
uniprot id: A0A8M2BGW9
uniprot id: A0A8M2BHE2
uniprot id: A0A8M6Z279
uniprot id: A0A8M6Z935
uniprot id: A0A8M9PXP5
uniprot id: A0A8M9PXQ2
uniprot id: A0A8M9Q9K7
uniprot id: A0A8M9QF96
uniprot id: A0A8M9QJK5
uniprot id: A0A8M9QNB1
uniprot id: Q6PGV0
names: Similarity
messages: Belongs to the LRRFIP family.

7955:hdac9b
gene id: 7955:hdac9b
uniprot id: A0A8M2B4U1
uniprot id: Q6PBI4
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting other histone deacetylases. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription (By similarity).
messages: Homodimer. Interacts with mef2 (By similarity).
messages: Intron retention.
messages: Nucleus

7955:egfra
gene id: 7955:egfra
uniprot id: Q7SZF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

7955:pros1
gene id: 7955:pros1
uniprot id: Q08BB9
names: Caution
names: Function
messages: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:myo1f
gene id: 7955:myo1f
uniprot id: A0A8M1P4K0
uniprot id: B0S6F2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:dip2cb
gene id: 7955:dip2cb
uniprot id: A0A8M2BIR2
uniprot id: A0A8N7TBX3
names: Similarity
messages: Belongs to the DIP2 family.

7955:LOC110437794
gene id: 7955:LOC110437794
uniprot id: A0A8M6Z7J4
names: Subcellular Location Annotation
messages: Membrane

7955:dnase1
gene id: 7955:dnase1
uniprot id: Q6DG72
names: Similarity
messages: Belongs to the DNase I family.

7955:ttc19
gene id: 7955:ttc19
uniprot id: A0A8M1PAE7
uniprot id: A0A8M9QKD1
uniprot id: F1QF34
names: Similarity
messages: Belongs to the TTC19 family.

7955:fam151b
gene id: 7955:fam151b
uniprot id: A0A8M2BJ37
uniprot id: A0A8M3ASG4
uniprot id: A0A8M3B9M4
uniprot id: A0A8M9Q342
uniprot id: A2BGP9
uniprot id: Q6DC01
names: Similarity
messages: Belongs to the FAM151 family.

7955:gdf11
gene id: 7955:gdf11
uniprot id: A0A8M2B1U5
uniprot id: A0A8M6Z378
uniprot id: Q8JFP9
names: Similarity
messages: Belongs to the TGF-beta family.

7955:fabp2
gene id: 7955:fabp2
uniprot id: A0A8M2BI88
uniprot id: Q8AX65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

7955:spg21
gene id: 7955:spg21
uniprot id: Q6PC62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily.
messages: Cytoplasm

7955:si:ch211-163l21.10
gene id: 7955:si:ch211-163l21.10
uniprot id: A0A8M1NHE7
uniprot id: T1ECT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues.
messages: Belongs to the BBOF1 family.
messages: cilium basal body

7955:lrrfip1b
gene id: 7955:lrrfip1b
uniprot id: A0A8M2BFZ6
uniprot id: A0A8M2BG01
uniprot id: A0A8M2BG03
uniprot id: A0A8M2BG13
uniprot id: A0A8M2BGK9
uniprot id: A0A8M3AT95
uniprot id: A0A8M3AT96
uniprot id: A0A8M3B0C1
uniprot id: A0A8M3B3B5
uniprot id: A0A8M3BAA5
uniprot id: A0A8M9PMM5
uniprot id: A0A8M9Q0A6
uniprot id: A0A8M9Q6M9
uniprot id: A0A8M9QAU2
uniprot id: A0A8M9QFV4
names: Similarity
messages: Belongs to the LRRFIP family.

7955:kcnn3
gene id: 7955:kcnn3
uniprot id: A0A8M3ATE4
uniprot id: E7FAT2
names: Subcellular Location Annotation
messages: Membrane

7955:LOC110438743
gene id: 7955:LOC110438743
uniprot id: A0A8M9P9B1
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:thbs4a
gene id: 7955:thbs4a
uniprot id: A0A0R4I9N1
uniprot id: A0A8M1NHG5
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cyp26c1
gene id: 7955:cyp26c1
uniprot id: A1L1M2
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:cenpl
gene id: 7955:cenpl
uniprot id: A0A8M1N1W5
uniprot id: F1QZ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

7955:c9
gene id: 7955:c9
uniprot id: A0A8M1P382
uniprot id: B8A565
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted
messages: Target cell membrane

7955:xkr6b
gene id: 7955:xkr6b
uniprot id: A0A8M1N402
uniprot id: F1R8C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:nfia
gene id: 7955:nfia
uniprot id: A0A8M3AM79
uniprot id: A0A8M3AM86
uniprot id: A0A8M3AMZ3
uniprot id: A0A8M3AUN3
uniprot id: A0A8M3AUN8
uniprot id: A0A8M3AXN2
uniprot id: A0A8M3B5H7
uniprot id: A1A5X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

7955:plxnd1
gene id: 7955:plxnd1
uniprot id: Q6DSU3
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cep170b
gene id: 7955:cep170b
uniprot id: A0A8M6YT69
uniprot id: A0A8M9PEF8
uniprot id: A0A8M9PKY7
uniprot id: A0A8M9PP02
names: Similarity
messages: Belongs to the CEP170 family.

7955:gtf3c5
gene id: 7955:gtf3c5
uniprot id: A0A8N7UT80
uniprot id: E7EZ29
names: Subcellular Location Annotation
messages: Nucleus

7955:cndp2
gene id: 7955:cndp2
uniprot id: A3KQX1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

7955:pnpla4
gene id: 7955:pnpla4
uniprot id: A3KNP7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pigk
gene id: 7955:pigk
uniprot id: Q6IQM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

7955:nts
gene id: 7955:nts
uniprot id: A0A0A7H8E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

7955:mtmr7b
gene id: 7955:mtmr7b
uniprot id: A0A8M2BFN3
uniprot id: Q4V8X2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7955:si:dkey-61p9.4
gene id: 7955:si:dkey-61p9.4
uniprot id: A0A0A0MPW9
uniprot id: A0A8M1REZ1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

7955:tnnt1
gene id: 7955:tnnt1
uniprot id: A0A8M9P738
uniprot id: A0A8M9PZE1
uniprot id: B3DG30
uniprot id: B3DH09
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

7955:mrpl49
gene id: 7955:mrpl49
uniprot id: E7F2U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

7955:top3b
gene id: 7955:top3b
uniprot id: F1QNX4
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

7955:LOC108190403
gene id: 7955:LOC108190403
uniprot id: A0A8M9QBI7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:insra
gene id: 7955:insra
uniprot id: A0A8M2BIL6
uniprot id: B7SNG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:gdf7
gene id: 7955:gdf7
uniprot id: A0A8N7TFB7
names: Similarity
messages: Belongs to the TGF-beta family.

7955:invs
gene id: 7955:invs
uniprot id: Q8UVC1
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds calmodulin via its IQ domains.
messages: Cytoplasm
messages: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling.
messages: The D-box (destruction box) mediate the interaction with APC proteins, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway.
messages: cytoskeleton

7955:sult1st6
gene id: 7955:sult1st6
uniprot id: Q6DHH8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:capza1b
gene id: 7955:capza1b
uniprot id: B5DDC0
uniprot id: Q6ZM50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

7955:si:dkey-23c22.6
gene id: 7955:si:dkey-23c22.6
uniprot id: A2RV47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:snrpf
gene id: 7955:snrpf
uniprot id: Q6DRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

7955:phactr1
gene id: 7955:phactr1
uniprot id: A0A8M1P9M3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

7955:kif20bb
gene id: 7955:kif20bb
uniprot id: A0A8M3B4I2
uniprot id: A0A8M9QJ37
uniprot id: A0A8M9QMV5
uniprot id: X1WGN9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:cldnc
gene id: 7955:cldnc
uniprot id: Q6P0W4
uniprot id: Q90XR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:si:dkeyp-41f9.4
gene id: 7955:si:dkeyp-41f9.4
uniprot id: A0A8M9PTU4
names: Subcellular Location Annotation
messages: Nucleus

7955:zgc:91968
gene id: 7955:zgc:91968
uniprot id: Q6GQM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the melanoregulin family.
messages: Cytoplasmic vesicle membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate.

7955:cx44.2
gene id: 7955:cx44.2
uniprot id: A0A8M9Q5X3
uniprot id: F1QYI2
uniprot id: Q7ZU26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:nkain4
gene id: 7955:nkain4
uniprot id: A0A8M2B8S8
uniprot id: A8WG59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

7955:si:ch211-209n20.1
gene id: 7955:si:ch211-209n20.1
uniprot id: A0A8M9PN31
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:gyltl1b
gene id: 7955:gyltl1b
uniprot id: Q66PG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity).
messages: Binds 2 Mn(2+) ions per subunit. The xylosyltransferase part binds one Mn(2+) and the beta-1,3-glucuronyltransferase part binds one Mn(2+).
messages: Golgi apparatus membrane
messages: In the C-terminal section; belongs to the glycosyltransferase 49 family.
messages: In the N-terminal section; belongs to the glycosyltransferase 8 family.

7955:sult2st1
gene id: 7955:sult2st1
uniprot id: A0A8M2B2C8
uniprot id: E7F734
uniprot id: Q6P2U4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:adam17b
gene id: 7955:adam17b
uniprot id: A0A8M9P2Y7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:zgc:163143
gene id: 7955:zgc:163143
uniprot id: A0A8M9PR62
uniprot id: A4IGI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

7955:eef1a2
gene id: 7955:eef1a2
uniprot id: Q6DHT2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

7955:pde5aa
gene id: 7955:pde5aa
uniprot id: A0A8M3AYL0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:disp2
gene id: 7955:disp2
uniprot id: Q6R5J1
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dispatched family.
messages: Membrane
messages: Ubiquitously expressed throughout the embryo from fertilization onward. Accumulates at higher levels in cells of the telencephalon, the ventral hindbrain and the gut.

7955:gria4b
gene id: 7955:gria4b
uniprot id: A0A8M1PI64
uniprot id: A0A8M9P377
uniprot id: A0A8M9PCI3
uniprot id: A0A8M9PI52
uniprot id: A0A8M9PQA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:LOC110438780
gene id: 7955:LOC110438780
uniprot id: A0A8M9Q1Y1
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:slc8a2b
gene id: 7955:slc8a2b
uniprot id: A0A8M3AIS0
uniprot id: B2CZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

7955:ptena
gene id: 7955:ptena
uniprot id: A0A8M1PHN1
uniprot id: Q6PC66
uniprot id: Q6TGR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

7955:mpi
gene id: 7955:mpi
uniprot id: Q3ZB95
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

7955:tmem47
gene id: 7955:tmem47
uniprot id: Q1LY05
uniprot id: Q6PFT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane
messages: Regulates cell junction organization in epithelial cells.
messages: adherens junction

7955:duox
gene id: 7955:duox
uniprot id: A0A8M6YYK2
uniprot id: A0A8M9P6X2
uniprot id: A0A8M9PVM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

7955:phf10
gene id: 7955:phf10
uniprot id: A0A8M1PBJ6
uniprot id: Z4YI11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

7955:gstk4
gene id: 7955:gstk4
uniprot id: A0A8M2B5A3
uniprot id: E9QB37
uniprot id: Q1RLT4
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

7955:grm2a
gene id: 7955:grm2a
uniprot id: A0A8M2BDP3
uniprot id: E7FDL9
uniprot id: U3N5X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7955:pycr1a
gene id: 7955:pycr1a
uniprot id: Q6P971
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

7955:tspan34
gene id: 7955:tspan34
uniprot id: Q0P3Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:hoxa11b
gene id: 7955:hoxa11b
uniprot id: B3DHW9
uniprot id: Q9DDU1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: First detected at 11.5 hours post-fertilization (hpf) in dorsal presomitic mesoderm and in the neural keel, extending to the ventral somitic mesoderm during tail budding. At 16-19 hpf, the rostral expression boundary is at somite 10. By the end of somitogenesis, expression decreases in the lateral and ventral mesoderm and becomes restricted to the neural rod. Also expressed in the developing pectoral fins from 34 hpf, with progressive localization to the periphery.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:si:dkey-30g5.1
gene id: 7955:si:dkey-30g5.1
uniprot id: A0A8M3ATP6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:hnrnpc
gene id: 7955:hnrnpc
uniprot id: A0A8M6Z8V1
uniprot id: Q803J4
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

7955:zgc:174260
gene id: 7955:zgc:174260
uniprot id: A0A8M1NHL5
uniprot id: A8KBW0
names: Similarity
messages: Belongs to the serpin family.

7955:pglyrp6
gene id: 7955:pglyrp6
uniprot id: A0A0R4IJX9
uniprot id: A0A8M1NA85
uniprot id: B7ZUU1
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

7955:si:ch211-284o19.8
gene id: 7955:si:ch211-284o19.8
uniprot id: A0A8M9PLB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7955:ltb4r
gene id: 7955:ltb4r
uniprot id: A0A0A8JWS4
uniprot id: X1WF65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:LOC100329560
gene id: 7955:LOC100329560
uniprot id: A7MCA7
uniprot id: Q5BJA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-111 promotes monoubiquitination of Lys-119. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-119 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ap2b1
gene id: 7955:ap2b1
uniprot id: Q6NYJ9
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

7955:cebpa
gene id: 7955:cebpa
uniprot id: Q8UVZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

7955:b4galt1l
gene id: 7955:b4galt1l
uniprot id: A0A8M2B441
uniprot id: C1KH59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

7955:aqp11
gene id: 7955:aqp11
uniprot id: A0A0R4IIL3
uniprot id: A0A8M1P9I6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:LOC799768
gene id: 7955:LOC799768
uniprot id: A0A8M3AZW8
names: Similarity
messages: Belongs to the arrestin family.

7955:rln1
gene id: 7955:rln1
uniprot id: G1FKB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

7955:abcc6a
gene id: 7955:abcc6a
uniprot id: A0A8M3AT69
uniprot id: E7F118
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

7955:agtrap
gene id: 7955:agtrap
uniprot id: A0A8M1P2E0
uniprot id: A0A8M9QHT1
uniprot id: E7F2K3
names: Subcellular Location Annotation
messages: Membrane

7955:cdc20
gene id: 7955:cdc20
uniprot id: A0A0R4IU39
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

7955:hoxd11a
gene id: 7955:hoxd11a
uniprot id: Q90470
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: First expressed at 12 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 11. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:hcn2b
gene id: 7955:hcn2b
uniprot id: A0A8M3B5M0
uniprot id: A0A8N7T6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

7955:hspb3
gene id: 7955:hspb3
uniprot id: A5JV81
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7955:plcg1
gene id: 7955:plcg1
uniprot id: Q804J6
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

7955:mrpl22
gene id: 7955:mrpl22
uniprot id: B0JZC1
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

7955:rnpc3
gene id: 7955:rnpc3
uniprot id: F1Q8J0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.
messages: Larval lethal with complete lethality by 10 days post-fertilization. Development of multiple organs is affected. Head, eye, lens, pancreas and liver are smaller than normal, and the swim bladder fails to inflate. The intestinal epithelium also remains thin and unfolded. U12-type introns are retained in mRNAs, whereas excision of U2-type introns is not affected. Assembly of both U12- and U11-containing snRNP complexes may be abnormal. Gene expression levels are broadly impacted; effects are not limited to U12-type intron-containing genes.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprise less than 1% of all non-coding sequences.
messages: Widely expressed until 24 hours post-fertilization (hpf), probably due to inheritance of maternal transcripts. Expression becomes restricted to lens, pharyngeal region, liver/pancreas anlage and intestine at 48-72 hpf. Strongly expressed in pancreas and intestine at 96-120 hpf.

7955:wdr48b
gene id: 7955:wdr48b
uniprot id: A0A8M2BFQ8
uniprot id: A0A8M2BFR4
uniprot id: Q6PFM9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Cytoplasm
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Nucleus
messages: Regulator of deubiquitinating complexes, which acts as a strong activator of usp1, usp12 and usp46. Enhances the usp1-mediated deubiquitination of fancd2; usp1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing usp12. Together with rad51ap1, promotes DNA repair by stimulating rad51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for usp1-mediated deubiquitination of fancd2 and stimulation of rad51-mediated homologous recombination: both wdr48/uaf1 and rad51ap1 have coordinated role in DNA-binding during these processes. Together with atad5 and by regulating usp1 activity, has a role in pcna-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated pcna. Together with atad5, has a role in recruiting rad51 to stalled forks during replication stress.
messages: The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46.

7955:zgc:158403
gene id: 7955:zgc:158403
uniprot id: A1A5Y5
names: Similarity
messages: Belongs to the TTC39 family.

7955:cited4b
gene id: 7955:cited4b
uniprot id: A8E5L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

7955:si:dkey-43k4.5
gene id: 7955:si:dkey-43k4.5
uniprot id: A0A8M6Z6V7
uniprot id: E7FFD5
names: Subcellular Location Annotation
messages: Membrane

7955:mtnr1bb
gene id: 7955:mtnr1bb
uniprot id: P51049
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: By cocaine, which increases the levels of day-time expression.
messages: Cell membrane
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).

7955:ccndbp1
gene id: 7955:ccndbp1
uniprot id: A3KNI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCNDBP1 family.
messages: Cytoplasm
messages: May negatively regulate cell cycle progression.
messages: Nucleus

7955:mtnr1ba
gene id: 7955:mtnr1ba
uniprot id: B3DJ99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.
messages: Membrane

7955:LOC100534973
gene id: 7955:LOC100534973
uniprot id: A0A8M6Z377
uniprot id: A0A8M9P2A0
uniprot id: A0A8M9PNY5
uniprot id: A0A8M9PS85
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIEZO (TC 1.A.75) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:or113-2
gene id: 7955:or113-2
uniprot id: Q2PRE4
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:112271
gene id: 7955:zgc:112271
uniprot id: Q502F6
names: Similarity
messages: Belongs to the BolA/IbaG family.

7955:veph1
gene id: 7955:veph1
uniprot id: A0A0R4I9B9
uniprot id: A2BID5
names: Developmental Stage
names: Domain
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MELT/VEPH family.
messages: Cell membrane
messages: Expressed at high levels in kidney, and at low levels in eye, brain, gill and heart.
messages: Expressed in diencephalon, mesencephalon, anterior hindbrain and otic vesicles at 24 hpf.
messages: The PH domain is required for membrane targeting.

7955:fam65c
gene id: 7955:fam65c
uniprot id: A0A8M2BDS6
uniprot id: A0A8M3ATQ2
uniprot id: F1R2W2
uniprot id: Q5EB20
names: Similarity
messages: Belongs to the RIPOR family.

7955:idh3a
gene id: 7955:idh3a
uniprot id: A0A8M2BAG2
uniprot id: Q6NV33
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

7955:olfml3b
gene id: 7955:olfml3b
uniprot id: Q29RB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Secreted
messages: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity).

7955:adma
gene id: 7955:adma
uniprot id: A0A8M1P2W6
uniprot id: E7F5V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

7955:fam207a
gene id: 7955:fam207a
uniprot id: Q1LWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

7955:osbpl1a
gene id: 7955:osbpl1a
uniprot id: A0A0R4IQ17
uniprot id: A0A8M9PQ26
uniprot id: A0A8M9Q392
names: Similarity
messages: Belongs to the OSBP family.

7955:si:ch73-173h19.3
gene id: 7955:si:ch73-173h19.3
uniprot id: A0A0R4IL08
uniprot id: A0A8M1NFF0
uniprot id: A0A8M3AXY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:med6
gene id: 7955:med6
uniprot id: Q6IQ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:setdb1a
gene id: 7955:setdb1a
uniprot id: Q1L8U8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (By similarity).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Nucleus

7955:arl8bb
gene id: 7955:arl8bb
uniprot id: A0A8M1P8N8
uniprot id: F1RBH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

7955:si:dkey-84o3.7
gene id: 7955:si:dkey-84o3.7
uniprot id: A0A8M6YUP2
uniprot id: E9QHZ3
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:celf5a
gene id: 7955:celf5a
uniprot id: A0A8M6YUY3
uniprot id: A0A8M6YVG1
uniprot id: A0A8M6YXB0
uniprot id: A0A8M9P4B2
uniprot id: A0A8M9P4B4
uniprot id: A0A8M9PDY0
uniprot id: A0A8M9PDY4
uniprot id: A0A8M9PJM3
uniprot id: A0A8M9PJM7
uniprot id: A0A8M9PRU9
uniprot id: A0A8M9PRV4
uniprot id: A0A8M9PVC1
uniprot id: A0A8M9PVC6
uniprot id: A0A8M9PVD1
uniprot id: B3DJA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

7955:daxx
gene id: 7955:daxx
uniprot id: A0A8M2B6F2
uniprot id: A0A8M6YWD7
uniprot id: Q1LUU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

7955:gba
gene id: 7955:gba
uniprot id: A0A8N7TAR5
uniprot id: E7EZM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Lysosome membrane

7955:LOC798191
gene id: 7955:LOC798191
uniprot id: A0A8M9PRR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:dclre1a
gene id: 7955:dclre1a
uniprot id: A0A8M1N609
uniprot id: E7F457
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

7955:LOC563292
gene id: 7955:LOC563292
uniprot id: A0A8M2BI45
uniprot id: A0A8N7UR26
names: Subcellular Location Annotation
messages: Nucleus

7955:il15l
gene id: 7955:il15l
uniprot id: A0A0R4IKC3
uniprot id: A0A8M2B3N9
uniprot id: A0A8M3ASP6
uniprot id: B3DFL4
uniprot id: F1QRP5
uniprot id: Q32PM5
uniprot id: Q5W7F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

7955:ndufb2
gene id: 7955:ndufb2
uniprot id: Q6PBN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

7955:cnksr2a
gene id: 7955:cnksr2a
uniprot id: A0A8M3APA0
uniprot id: A0A8M3AW25
uniprot id: A0A8M3AZ62
uniprot id: A0A8M3B6Q4
uniprot id: A0A8M6Z4T4
uniprot id: A0A8M9PUH1
uniprot id: A0A8M9PXZ0
names: Similarity
messages: Belongs to the CNKSR family.

7955:arhgef7a
gene id: 7955:arhgef7a
uniprot id: A0A8M2BEZ3
uniprot id: A0A8M2BF17
uniprot id: A0A8M2BF23
uniprot id: A0A8M6Z2J5
uniprot id: A0A8M9Q4K4
uniprot id: A0A8M9QAP8
uniprot id: A0A8M9QJM4
uniprot id: A0A8N1Z0S2
uniprot id: B0S771
names: Subcellular Location Annotation
messages: lamellipodium

7955:itga5
gene id: 7955:itga5
uniprot id: Q5I2A9
uniprot id: Q6QAF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:nupl2
gene id: 7955:nupl2
uniprot id: Q6P0U9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Nucleus membrane
messages: Probable component of the nuclear pore complex (NPC).
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
messages: The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.
messages: nuclear pore complex

7955:si:ch211-121a2.2
gene id: 7955:si:ch211-121a2.2
uniprot id: A0A8M9P2P2
uniprot id: A0A8M9PPG8
uniprot id: A7MBU0
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.

7955:sypa
gene id: 7955:sypa
uniprot id: B0S5B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

7955:larsb
gene id: 7955:larsb
uniprot id: A0A8N7T837
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:ugt1b1
gene id: 7955:ugt1b1
uniprot id: D3XD60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:admb
gene id: 7955:admb
uniprot id: A0A8M9Q9S2
uniprot id: E7FDI6
names: Similarity
messages: Belongs to the calcitonin family.

7955:itpa
gene id: 7955:itpa
uniprot id: A5WVX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

7955:tagln3a
gene id: 7955:tagln3a
uniprot id: A2BEV4
uniprot id: A7MBS8
names: Similarity
messages: Belongs to the calponin family.

7955:npy4r
gene id: 7955:npy4r
uniprot id: B3DIJ2
uniprot id: O73733
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:lyn
gene id: 7955:lyn
uniprot id: A0A8M2BAN0
uniprot id: Q66I04
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:tnksb
gene id: 7955:tnksb
uniprot id: A0A0R4IYN3
uniprot id: A0A8M2BJ10
uniprot id: A0A8M2BJ18
uniprot id: A0A8M2BJJ1
uniprot id: A3KGU1
uniprot id: B3DG38
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:LOC100007727
gene id: 7955:LOC100007727
uniprot id: A0A8M9Q5N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:LOC110439897
gene id: 7955:LOC110439897
uniprot id: A0A8M9QC15
names: Subcellular Location Annotation
messages: Membrane

7955:atp1a1a.2
gene id: 7955:atp1a1a.2
uniprot id: Q9DGL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

7955:zdhhc17
gene id: 7955:zdhhc17
uniprot id: A5WVX9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Morpholino knockdown of the protein does not apparently affect embryo development (PubMed:26232532). However, the motility of morphants is markedly reduced from 3 days post-fertilization onwards (PubMed:26232532). This is associated with a significant defect in the axonal outgrowth of spinal motor neurons without affecting neuron generation (PubMed:26232532).
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays a role in axonogenesis (PubMed:26232532).
messages: Presynaptic cell membrane
messages: Probably maternally supplied, the zygotic expression becomes significative at 2.75 hpf and then decreases after 18 hpf but is still detected at 24 hpf (PubMed:26056731, PubMed:27235108). Highly expressed in the developing central nervous system from the presumptive telencephalon to the caudal tip of the spinal cord (PubMed:26232532).
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:LOC101882949
gene id: 7955:LOC101882949
uniprot id: A0A8M6YV11
uniprot id: A0A8M9PTI4
names: Similarity
messages: Belongs to the EVA1 family.

7955:csf1rb
gene id: 7955:csf1rb
uniprot id: A0A8M3AX73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:rbp2a
gene id: 7955:rbp2a
uniprot id: Q8UVG6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

7955:pax2b
gene id: 7955:pax2b
uniprot id: O93370
names: Subcellular Location Annotation
messages: Nucleus

7955:cwc15
gene id: 7955:cwc15
uniprot id: A5WV15
names: Similarity
messages: Belongs to the CWC15 family.

7955:LOC101885160
gene id: 7955:LOC101885160
uniprot id: A0A8M2BGC8
uniprot id: E7F718
names: Subcellular Location Annotation
messages: Secreted

7955:ptk6a
gene id: 7955:ptk6a
uniprot id: A0A8N7TED1
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:rergla
gene id: 7955:rergla
uniprot id: Q6DGN0
names: Function
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Binds GDP/GTP and may possess intrinsic GTPase activity.

7955:plxna1a
gene id: 7955:plxna1a
uniprot id: A0A8M1RJK2
uniprot id: A0A8M6Z3W4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:atp2b2
gene id: 7955:atp2b2
uniprot id: A0A8M9QD45
uniprot id: B2CZB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:slc37a4a
gene id: 7955:slc37a4a
uniprot id: A0A8M3AH42
uniprot id: F1R0A9
uniprot id: Q6NY67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

7955:gins1
gene id: 7955:gins1
uniprot id: Q5XJQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

7955:galnt8a.1
gene id: 7955:galnt8a.1
uniprot id: A0A8M9PHA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:cpne5a
gene id: 7955:cpne5a
uniprot id: A0A8M3AV55
uniprot id: A0A8N7UYV3
uniprot id: B0R0N3
names: Similarity
messages: Belongs to the copine family.

7955:pacs2
gene id: 7955:pacs2
uniprot id: A0A8M3AZB0
uniprot id: A0A8M3AZD0
uniprot id: A0A8M3B5F0
uniprot id: A0A8M3BET2
uniprot id: B1NJ27
names: Similarity
messages: Belongs to the PACS family.

7955:kcns3b
gene id: 7955:kcns3b
uniprot id: Q32LW7
names: Subcellular Location Annotation
messages: Membrane

7955:wu:fi04e12
gene id: 7955:wu:fi04e12
uniprot id: A0A8M9P346
uniprot id: A0A8M9PQ61
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plakin or cytolinker family.
messages: Cell membrane
messages: Expressed in the blastula and widely expressed in the gastrula from 3 hours post-fertilization (hpf) to 6 hpf (PubMed:29522173). Expressed in the epidermis from 16 hpf (PubMed:29522173). Expressed through the epidermis, lens, otic vesicle, pharynx, pectoral fin, and heart from 1 dpf to 5 dpf (PubMed:29522173).
messages: Involved in the organization of desmosome cell-cell junctions (PubMed:29522173). Of particular importance in cell adhesion in the skin and during cardiac development (PubMed:29522173). May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways (PubMed:29522173).
messages: Morpholino knockdowns show no general morphological differences however do show a slight developmental delay (PubMed:29522173). Abnormal skin surface, reduced numbers of desmosome cell-cell junctions and disorganization of remaining desmosome at 2 dpf (PubMed:29522173). Cardiac regions show reduced desmosome numbers, detached cells and pericardial effusion (PubMed:29522173). A cardiac reduction in Wnt and TGF-beta signaling is also evident, with an increase in Hippo signaling (PubMed:29522173).
messages: cytoskeleton
messages: desmosome

7955:osbpl10b
gene id: 7955:osbpl10b
uniprot id: A0A8M1RMC5
uniprot id: A0A8M2B4K8
uniprot id: A0A8M2B559
uniprot id: A0A8M9NZT9
uniprot id: E7FE64
uniprot id: E9QDU3
names: Similarity
messages: Belongs to the OSBP family.

7955:cmpk
gene id: 7955:cmpk
uniprot id: A0A8N1TQ43
uniprot id: A5WWI2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

7955:gipc2
gene id: 7955:gipc2
uniprot id: A9JRQ0
uniprot id: Q7ZV93
names: Similarity
messages: Belongs to the GIPC family.

7955:mcu
gene id: 7955:mcu
uniprot id: K0A5D6
uniprot id: Q08BI9
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Component of the uniplex complex (By similarity). Homooligomer; forms a pentamer (By similarity).
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Inhibited by ruthenium red or its derivative Ru360.
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by micu1 and micu2. At low Ca(2+) levels mcu activity is down-regulated by micu1 and micu2; at higher Ca(2+) levels micu1 increases mcu activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells.
messages: Mitochondrion inner membrane
messages: The N-terminal MCU domain is required for efficient Ca(2+) uptake and for interaction with MCUR1. It is not required for targeting to the mitochondria, oligomerization, interaction with MICU1 and MICU2, or assembly of the uniplex complex.
messages: The critical DXXE motif connecting the transmembrane regions forms a pentameric barrel that constitutes the mouth of the pore. Inside the barrel, two acidic residues are in position to form two carboxylate rings. In absence of SMDT1/EMRE regulator, the calcium ions cannot exit the channel, suggesting that SMDT1/EMRE-binding induces conformational rearrangements to allow calcium to exit.

7955:mafba
gene id: 7955:mafba
uniprot id: A0A2U3TVD3
uniprot id: A0A8M1PB55
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

7955:paox1
gene id: 7955:paox1
uniprot id: A0A8M1NH10
uniprot id: A8WHP1
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

7955:arsh
gene id: 7955:arsh
uniprot id: A0A8M1RIV1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7955:LOC103911968
gene id: 7955:LOC103911968
uniprot id: A0A8M3B4Y0
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

7955:lzts2a
gene id: 7955:lzts2a
uniprot id: A0A288CG34
uniprot id: A0A8M1NQ64
uniprot id: A0A8M3AZ07
uniprot id: B8A6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

7955:gpc6a
gene id: 7955:gpc6a
uniprot id: A0A8M9Q7F3
uniprot id: A7MBT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

7955:fga
gene id: 7955:fga
uniprot id: A0A8M1NUN6
uniprot id: B8A5L6
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

7955:smarcd1
gene id: 7955:smarcd1
uniprot id: B2GS37
uniprot id: Q802C8
names: Similarity
messages: Belongs to the SMARCD family.

7955:sep15
gene id: 7955:sep15
uniprot id: Q802F3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the selenoprotein M/F family.
messages: Endoplasmic reticulum lumen
messages: Higher levels in polster, prechordal plate, axis, otic vesicle and somites. Lower levels in fin buds.
messages: May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity).

7955:dynlt1
gene id: 7955:dynlt1
uniprot id: A0A8M1NIL8
uniprot id: F1Q5L5
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7955:hs3st4
gene id: 7955:hs3st4
uniprot id: A0A8N7UYK9
uniprot id: F1QME4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:trim54
gene id: 7955:trim54
uniprot id: A0A8N1TQ49
uniprot id: Q5RHH1
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

7955:zgc:55262
gene id: 7955:zgc:55262
uniprot id: Q7ZUR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

7955:ebf3a
gene id: 7955:ebf3a
uniprot id: A0A286Y8W0
uniprot id: A0A8M2B2G9
uniprot id: A0A8M2B2H2
uniprot id: A0A8M2B2S0
uniprot id: A0A8M2B362
uniprot id: A0A8M2B369
uniprot id: A0A8M2B3A0
uniprot id: A0A8M2B3A6
uniprot id: A0A8M3AYM5
uniprot id: A0A8M3AYP6
uniprot id: A0A8M3B4V8
uniprot id: A0A8M3B7N8
uniprot id: A0A8M3BEC3
uniprot id: A0A8M3BEC5
uniprot id: A1L2E2
uniprot id: B2GPA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

7955:lgsn
gene id: 7955:lgsn
uniprot id: Q29RF4
names: Similarity
messages: Belongs to the glutamine synthetase family.

7955:sema3fa
gene id: 7955:sema3fa
uniprot id: A0A2R8QJ63
uniprot id: A0A8M2BDF1
uniprot id: A0A8M2BDK2
uniprot id: F1QPG9
uniprot id: Q5ID24
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:kcnq5b
gene id: 7955:kcnq5b
uniprot id: A0A8N7URC3
uniprot id: F1RB62
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:cox6a1
gene id: 7955:cox6a1
uniprot id: Q642I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:zgc:173652
gene id: 7955:zgc:173652
uniprot id: Q561S9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:acsl1a
gene id: 7955:acsl1a
uniprot id: A0A8M2BFN1
uniprot id: B8JK22
uniprot id: Q499A9
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

7955:gpd1b
gene id: 7955:gpd1b
uniprot id: Q7T1E0
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

7955:mblac1
gene id: 7955:mblac1
uniprot id: A0A8M9Q8J5
uniprot id: A0A8N7TBB9
uniprot id: F1QIZ3
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

7955:ganab
gene id: 7955:ganab
uniprot id: A0A8M3AI40
uniprot id: F1Q6Z9
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

7955:cplx2
gene id: 7955:cplx2
uniprot id: A0A0R4IS84
uniprot id: A0A8M9QGE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

7955:gucy1b2
gene id: 7955:gucy1b2
uniprot id: A0A8N7TEB2
uniprot id: E7F6T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

7955:actn1
gene id: 7955:actn1
uniprot id: A0A8M2B3U1
uniprot id: A0A8M3AZC5
uniprot id: A0A8M3B5E5
uniprot id: A0A8M3B867
uniprot id: B8JHU4
names: Similarity
messages: Belongs to the alpha-actinin family.

7955:gna14a
gene id: 7955:gna14a
uniprot id: A0A2R8RNG4
uniprot id: A0A8N7TCS1
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

7955:creb3l3b
gene id: 7955:creb3l3b
uniprot id: A0A8M3AQI2
uniprot id: A0A8M6Z2L5
uniprot id: E7FGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:tgfbi
gene id: 7955:tgfbi
uniprot id: Q7T1R2
names: Subcellular Location Annotation
messages: extracellular matrix

7955:si:dkey-110k5.10
gene id: 7955:si:dkey-110k5.10
uniprot id: A0A8M3ASD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

7955:ndufaf7
gene id: 7955:ndufaf7
uniprot id: Q08BY0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:24838397). Acts by mediating symmetric dimethylation of 'Arg-118' of ndufs2 after it assembles into the complex I, stabilizing the early intermediate complex.
messages: Belongs to the NDUFAF7 family.
messages: Impaired NADH:ubiquinone oxidoreductase complex (complex I) assembly.
messages: Mitochondrion

7955:atp5j2
gene id: 7955:atp5j2
uniprot id: A0A8M1P1Q0
uniprot id: F6P873
names: Function
names: Similarity
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

7955:si:ch73-252i11.1
gene id: 7955:si:ch73-252i11.1
uniprot id: A0A8M1P914
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:camk1db
gene id: 7955:camk1db
uniprot id: B5MF71
uniprot id: B5MF72
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:spred2b
gene id: 7955:spred2b
uniprot id: Q6NYK3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Morpholino knockdown is associated with increased Erk phosphorylation levels and results in a high incidence of embryos showing delayed gastrulation, or delay in elongation during the segmentation stage, with reduced formation of the head and tailbud. Morphants show yolk elongation at 12 hours post-fertilization, indicating enhanced MAPK signaling.
messages: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.
messages: secretory vesicle membrane

7955:zdhhc3b
gene id: 7955:zdhhc3b
uniprot id: A0JPF8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:snx20
gene id: 7955:snx20
uniprot id: A0A2R9YJQ2
uniprot id: A0A8M2BA68
uniprot id: A0A8M3APX6
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Membrane

7955:galca
gene id: 7955:galca
uniprot id: Q5SNX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 59 family.
messages: Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine.
messages: Lysosome

7955:duox2
gene id: 7955:duox2
uniprot id: A0A8M1RI64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

7955:cnn3b
gene id: 7955:cnn3b
uniprot id: Q32PU2
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

7955:si:ch1073-138d10.2
gene id: 7955:si:ch1073-138d10.2
uniprot id: A0A8M3AYS7
uniprot id: A0A8M9PX16
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

7955:srpx
gene id: 7955:srpx
uniprot id: A0A8M2BFS2
uniprot id: Q58ED3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pimr62
gene id: 7955:pimr62
uniprot id: A0A8M9PLQ8
uniprot id: A0A8M9PPT0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:syt14a
gene id: 7955:syt14a
uniprot id: A0A8M6Z1S5
uniprot id: A0A8M6Z9M8
uniprot id: A0A8M9PYR8
names: Similarity
messages: Belongs to the synaptotagmin family.

7955:fxr2
gene id: 7955:fxr2
uniprot id: Q6NY99
names: Similarity
messages: Belongs to the FMR1 family.

7955:aqr
gene id: 7955:aqr
uniprot id: B1H1M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWF11 family.
messages: Nucleus

7955:ovgp1
gene id: 7955:ovgp1
uniprot id: A0A8M9PW02
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

7955:glrx5
gene id: 7955:glrx5
uniprot id: Q6PBM1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Detected in embryonic intermediate cell mass (site of hematopoiesis), liver and heart.
messages: Homodimer.
messages: Lethal between 7 and 10 dpf. Embryos show hypochromia, and circulating blood cells are pale due to a defect in hemoglobin biosynthesis.
messages: Mitochondrion
messages: Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:16110529). Receives iron-sulfur clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:16110529). Required for normal hemoglobin biosynthesis (PubMed:16110529).

7955:zgc:158320
gene id: 7955:zgc:158320
uniprot id: A0PJR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: nucleoplasm

7955:rsph9
gene id: 7955:rsph9
uniprot id: Q5TYW6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flagellar radial spoke RSP9 family.
messages: Component of the axonemal radial spoke head which plays an important role in ciliary motility (PubMed:19200523). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (PubMed:27687975). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity).
messages: Dysmotile olfactory pit cilia which have a normal beat frequency but an ineffective circular beat pattern. Effect can be rescued by coinjection of mouse Rsph9 mRNA (PubMed:19200523). Embryos with CRISPR-induced rsph9 null mutations exhibit a greatly diminished olfactory and neural ciliary motility, structural defects in neural and pronephric ciliary axonemes and an impaired initiation of startle response to acoustic stimulation (PubMed:27687975).
messages: Expressed in ciliated structures in the embryos namely, Kupffer's vesicle, pronephric ducts, otic placodes and ventral spinal cord (at protein level) (PubMed:27687975). Also expressed in the ventral midline of the midbrain primordium (at protein level) (PubMed:27687975).
messages: cilium axoneme
messages: flagellum
messages: kinocilium

7955:gpr156
gene id: 7955:gpr156
uniprot id: E7F1E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:LOC100001114
gene id: 7955:LOC100001114
uniprot id: A0A8M2B9W8
uniprot id: A0A8M2B9X0
uniprot id: A0A8M2B9X1
uniprot id: A0A8M2B9Z3
uniprot id: A0A8M2BA06
uniprot id: A0A8M2BA22
uniprot id: A0A8M2BA80
uniprot id: A0A8M2BA84
names: Subcellular Location Annotation
messages: cytoskeleton

7955:srp19
gene id: 7955:srp19
uniprot id: Q7T3C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

7955:chrm2b
gene id: 7955:chrm2b
uniprot id: A0A8M9Q5D6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

7955:dck
gene id: 7955:dck
uniprot id: Q5XJM2
names: Similarity
messages: Belongs to the DCK/DGK family.

7955:ctsh
gene id: 7955:ctsh
uniprot id: Q6NWF2
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:slc35c1
gene id: 7955:slc35c1
uniprot id: A0A8M2BH03
uniprot id: Q5PR94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

7955:camsap2a
gene id: 7955:camsap2a
uniprot id: A0A8M1N9R0
uniprot id: A0A8M2BHT6
uniprot id: A0A8M2BHT9
uniprot id: A0A8M3AN06
uniprot id: A0A8M3B5I3
uniprot id: Q1LUF1
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

7955:slc4a5
gene id: 7955:slc4a5
uniprot id: A0A8M9PUG6
uniprot id: A0A8M9Q6S5
uniprot id: A0A8M9QCR8
uniprot id: A0A8M9QHC3
uniprot id: A0A8M9QHC7
uniprot id: A0A8M9QLB8
uniprot id: A0A8M9QLC1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:dpydb
gene id: 7955:dpydb
uniprot id: Q6NYG8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 2 FAD.
messages: Binds 2 FMN.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

7955:mxe
gene id: 7955:mxe
uniprot id: A0A8M2BF41
uniprot id: Q800G5
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: By interferons.
messages: Cytoplasm

7955:p2rx8
gene id: 7955:p2rx8
uniprot id: Q7SZM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

7955:ddx61
gene id: 7955:ddx61
uniprot id: E7F1G8
names: Similarity
messages: Belongs to the DEAD box helicase family.

7955:sf3a1
gene id: 7955:sf3a1
uniprot id: Q90X41
names: Subcellular Location Annotation
messages: Nucleus

7955:atp1a1b
gene id: 7955:atp1a1b
uniprot id: Q9DEU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

7955:pik3ip1
gene id: 7955:pik3ip1
uniprot id: Q7SXB3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.

7955:LOC101885849
gene id: 7955:LOC101885849
uniprot id: F1RCF2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:ch211-117c9.5
gene id: 7955:si:ch211-117c9.5
uniprot id: A0A8M1QR72
uniprot id: A0A8M3B5X2
uniprot id: E7EXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:mgat1a
gene id: 7955:mgat1a
uniprot id: A0A8M2B420
uniprot id: F1QTA6
uniprot id: Q6PE41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

7955:enoph1
gene id: 7955:enoph1
uniprot id: B2GQ43
uniprot id: Q6GMI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

7955:LOC110438804
gene id: 7955:LOC110438804
uniprot id: A0A8M9QF43
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:mapkap1
gene id: 7955:mapkap1
uniprot id: A0A8M1RND7
uniprot id: E7EZP2
names: Similarity
messages: Belongs to the SIN1 family.

7955:ptpra
gene id: 7955:ptpra
uniprot id: A0A8M1P790
uniprot id: A0A8M9P361
uniprot id: F1QE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

7955:LOC799889
gene id: 7955:LOC799889
uniprot id: A0A8M9PAW7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:gatsl2
gene id: 7955:gatsl2
uniprot id: Q7ZVS6
names: Similarity
messages: Belongs to the GATS family.

7955:ywhabb
gene id: 7955:ywhabb
uniprot id: Q7T356
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).
messages: Belongs to the 14-3-3 family.
messages: Cytoplasm
messages: Homodimer, and heterodimer with other family members.

7955:wasa
gene id: 7955:wasa
uniprot id: A0A8N7TFI4
uniprot id: F1Q6U7
names: Subcellular Location Annotation
messages: Nucleus

7955:atp1a1a.3
gene id: 7955:atp1a1a.3
uniprot id: Q9DEY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cldn11a
gene id: 7955:cldn11a
uniprot id: Q6DHL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:meox2a
gene id: 7955:meox2a
uniprot id: E7FEH1
names: Subcellular Location Annotation
messages: Nucleus

7955:adora2ab
gene id: 7955:adora2ab
uniprot id: Q29ST5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

7955:cyp2n13
gene id: 7955:cyp2n13
uniprot id: Q5U3D5
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:slc16a13
gene id: 7955:slc16a13
uniprot id: A0A8M9Q8F8
names: Subcellular Location Annotation
messages: Membrane

7955:sirt3
gene id: 7955:sirt3
uniprot id: A0A8M3B4G2
names: Cofactor
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.

7955:lpar4
gene id: 7955:lpar4
uniprot id: A0A0N4STT7
uniprot id: A0A8M1Q725
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:fgfbp2b
gene id: 7955:fgfbp2b
uniprot id: A3KP08
uniprot id: F1QLT3
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

7955:LOC101886422
gene id: 7955:LOC101886422
uniprot id: A0A8M6Z9G0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:iqsec3b
gene id: 7955:iqsec3b
uniprot id: A0A0R4ITB4
uniprot id: A0A8M3AK89
uniprot id: A0A8M3B2R7
uniprot id: A0A8N7UUK6
names: Similarity
messages: Belongs to the BRAG family.

7955:scap
gene id: 7955:scap
uniprot id: A0A8M2B4M5
uniprot id: E9QEH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

7955:or122-2
gene id: 7955:or122-2
uniprot id: Q2PRI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:opn4a
gene id: 7955:opn4a
uniprot id: Q2KNE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Cell membrane
messages: Photoreceptor implicated in non-image-forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).

7955:puraa
gene id: 7955:puraa
uniprot id: Q6JIZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

7955:man2c1
gene id: 7955:man2c1
uniprot id: A0A8M3B7A6
uniprot id: A0A8M6YW39
uniprot id: A0A8N7TBS0
uniprot id: X1WCE5
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

7955:hoga1
gene id: 7955:hoga1
uniprot id: Q6NY77
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.
messages: Inhibited by divalent cations.
messages: Mitochondrion

7955:bmpr1bb
gene id: 7955:bmpr1bb
uniprot id: C0L3D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:slc20a1b
gene id: 7955:slc20a1b
uniprot id: F1QI67
uniprot id: Q6PFM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

7955:nsun6
gene id: 7955:nsun6
uniprot id: A0A0R4IAT4
uniprot id: A0A8M6Z0B3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

7955:rbp2b
gene id: 7955:rbp2b
uniprot id: Q6IVM1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

7955:gtf2ird1
gene id: 7955:gtf2ird1
uniprot id: A0A8M1RNF2
uniprot id: A0A8M9PLI6
uniprot id: A0A8M9QEX5
names: Subcellular Location Annotation
messages: Nucleus

7955:emp3b
gene id: 7955:emp3b
uniprot id: Q4V8V3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:vars
gene id: 7955:vars
uniprot id: A0A8M1P7Y5
uniprot id: F1Q740
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:mak16
gene id: 7955:mak16
uniprot id: A0A8M1PBW3
uniprot id: F1QDC7
names: Similarity
messages: Belongs to the MAK16 family.

7955:shq1
gene id: 7955:shq1
uniprot id: A0A8M1NBN6
uniprot id: A0A8M2BDH4
uniprot id: F1QC67
names: Similarity
messages: Belongs to the SHQ1 family.

7955:slc2a1a
gene id: 7955:slc2a1a
uniprot id: Q285P3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:scamp5a
gene id: 7955:scamp5a
uniprot id: Q6P0C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family. SCAMP5 subfamily.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Recycling endosome membrane
messages: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines. Probably acts in cooperation with the SNARE machinery (By similarity).
messages: synaptic vesicle membrane
messages: trans-Golgi network membrane

7955:nog2
gene id: 7955:nog2
uniprot id: Q9W740
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: First appears at the end of gastrulation in the axial mesoderm. By the 5-somite stage, expressed in telencephalon and anterior diencephalon. From early segmentation stages until the end of tail elongation, found in the tail bud. Expression is maintained during somitogenesis. At the 10-somite stage, detected in the antero-medial aspect of the somites. At 20 hours of development expression is observed in the ventro-medial part of the somite as well as in a small population of cells located more dorsally, adjacent to the neural tube. As development proceeds, expression in the dorsal somite is progressively lost, while ventro-medial sclerotomal cells lining the developing axial vasculature continue to show expression until 30 hours of development. In the head, expression is maintained in the telencephalon and anterior diencephalon until late embryogenesis. At the 15-somite stage, expressed in the forebrain, dorsal hindbrain and dorsal caudal spinal cord. Until late stages of embryogenesis strong expression is observed in the dorsal hindbrain walls.
messages: Homodimer; disulfide-linked.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling.
messages: Secreted

7955:fmnl1b
gene id: 7955:fmnl1b
uniprot id: A0A8M3APF0
names: Similarity
messages: Belongs to the formin homology family.

7955:calm3b
gene id: 7955:calm3b
uniprot id: Q6PI52
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

7955:LOC110440067
gene id: 7955:LOC110440067
uniprot id: A0A8M9QCC5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:fbln2
gene id: 7955:fbln2
uniprot id: A0A8M1Q7L7
uniprot id: A0A8M2BH82
uniprot id: F1RCR3
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:or125-2
gene id: 7955:or125-2
uniprot id: Q2PRA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:tmem115
gene id: 7955:tmem115
uniprot id: Q1LVD9
uniprot id: Q4V8Z5
names: Subcellular Location Annotation
messages: Membrane

7955:si:dkey-261m9.19
gene id: 7955:si:dkey-261m9.19
uniprot id: A0A8M1QVF6
uniprot id: X1WDH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:wu:fd46c06
gene id: 7955:wu:fd46c06
uniprot id: A9JSU2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:nr2f6b
gene id: 7955:nr2f6b
uniprot id: A0A8M9Q751
uniprot id: Q6P115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:unc13bb
gene id: 7955:unc13bb
uniprot id: A0A8M6Z8E2
uniprot id: A0A8M9PTX4
uniprot id: A0A8M9Q6D6
uniprot id: A0A8M9QCD0
uniprot id: A0A8M9QGV7
uniprot id: A0A8M9QGW1
uniprot id: A0A8M9QKX5
uniprot id: A0A8M9QKX9
names: Subcellular Location Annotation
messages: Cytoplasm

7955:cyp2k17
gene id: 7955:cyp2k17
uniprot id: A4FVL4
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:mmp16b
gene id: 7955:mmp16b
uniprot id: A0A8M3AMT4
uniprot id: A0A8N7TFK6
uniprot id: F1R8N4
names: Similarity
messages: Belongs to the peptidase M10A family.

7955:tmem106c
gene id: 7955:tmem106c
uniprot id: Q08BL5
names: Similarity
messages: Belongs to the TMEM106 family.

7955:vasnb
gene id: 7955:vasnb
uniprot id: A4QNV9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:gprin1
gene id: 7955:gprin1
uniprot id: A0A8M2BI32
names: Function
messages: May be involved in neurite outgrowth.

7955:sugp1
gene id: 7955:sugp1
uniprot id: A0A8M1RIH6
uniprot id: A0A8M3AQ46
uniprot id: A0A8M6YWN7
uniprot id: A0A8M9P2J9
uniprot id: A0A8M9PBP7
uniprot id: A0A8M9PPA2
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC567498
gene id: 7955:LOC567498
uniprot id: A0A8M2B706
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:LOC110438105
gene id: 7955:LOC110438105
uniprot id: A0A8M9PQW4
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch211-214p13.9
gene id: 7955:si:ch211-214p13.9
uniprot id: A0A8M1RSR2
uniprot id: A0A8M2BES3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:aqp10a
gene id: 7955:aqp10a
uniprot id: Q6DHQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7955:hmmr
gene id: 7955:hmmr
uniprot id: A0A8M1PD31
uniprot id: A0A8M9PZ19
uniprot id: E7EYJ3
names: Subcellular Location Annotation
messages: spindle

7955:ube2d3
gene id: 7955:ube2d3
uniprot id: A9JRT4
uniprot id: Q7ZUR2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:si:dkey-261m9.17
gene id: 7955:si:dkey-261m9.17
uniprot id: A0A8M9PVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:grem1a
gene id: 7955:grem1a
uniprot id: Q6T937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

7955:LOC793449
gene id: 7955:LOC793449
uniprot id: A0A8M9PQ62
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:pvalb3
gene id: 7955:pvalb3
uniprot id: Q7ZT36
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

7955:megf6b
gene id: 7955:megf6b
uniprot id: A0A8M3B4A3
uniprot id: A0A8M9PVQ9
uniprot id: A0A8M9QIB9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:173593
gene id: 7955:zgc:173593
uniprot id: A0A8M6YXP1
uniprot id: F1R872
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

7955:gstt1a
gene id: 7955:gstt1a
uniprot id: E7EZ94
names: Similarity
messages: Belongs to the GST superfamily. Theta family.

7955:znf598
gene id: 7955:znf598
uniprot id: Q6PFK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ZNF598 family.
messages: Component of the 4EHP-GYF2 complex.
messages: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of a subset of 40S ribosomal subunits. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide.

7955:tmod2
gene id: 7955:tmod2
uniprot id: Q66I39
names: Subcellular Location Annotation
messages: cytoskeleton

7955:eef2a.1
gene id: 7955:eef2a.1
uniprot id: A0A8M1NA43
uniprot id: Q1LYG5
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

7955:ppardb
gene id: 7955:ppardb
uniprot id: A9C4A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:ppp2r5d
gene id: 7955:ppp2r5d
uniprot id: Q6NWX4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

7955:mrgbp
gene id: 7955:mrgbp
uniprot id: A0A8M2B8V8
uniprot id: E9QJ55
uniprot id: Q6PC03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

7955:si:ch73-51i5.2
gene id: 7955:si:ch73-51i5.2
uniprot id: A0A8M9Q8S2
names: Similarity
messages: Belongs to the FAM13 family.

7955:si:ch211-285c6.1
gene id: 7955:si:ch211-285c6.1
uniprot id: A0A8N7USU2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:foxo4
gene id: 7955:foxo4
uniprot id: F1R3E6
names: Subcellular Location Annotation
messages: Nucleus

7955:slc25a28
gene id: 7955:slc25a28
uniprot id: B8A686
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:mab21l2
gene id: 7955:mab21l2
uniprot id: Q8UUZ1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Expressed from 11 hours post-fertilization (hpf). Expression in the midbrain and optic primordia begins at the onset of segmentation and increases to 14 hpf, remaining strong during lateral migration of the optic primordia. Expressed in the neural tube and the oblongated retinal epithelium from 18 hpf. Expression within the differentiating eyes subsequently decreases from 22 hpf to 35 hpf, with only weak expression at the edge of the lens observed from 35 hpf to 48 hpf. Expressed in the branchial pouches from 22 hpf, and in the pharyngeal arches, ganglia and hindbrain and spinal cord neurons from 24 hpf. Expressed in the lens perimeter and the differentiated amacrine and ganglion cell layers at 72 hpf.
messages: Nucleus
messages: Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells.
messages: Severe lens and retinal defects leading to lethality.

7955:osbpl3a
gene id: 7955:osbpl3a
uniprot id: A0A8M2BHB5
uniprot id: Q1LW95
uniprot id: Q66L55
names: Similarity
messages: Belongs to the OSBP family.

7955:zgc:101564
gene id: 7955:zgc:101564
uniprot id: B0S6J4
names: Similarity
messages: Belongs to the FAM72 family.

7955:slc2a6
gene id: 7955:slc2a6
uniprot id: A0A8N7TDP0
uniprot id: F1RB41
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:cxcl8b.3
gene id: 7955:cxcl8b.3
uniprot id: A9ZPF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

7955:gorasp2
gene id: 7955:gorasp2
uniprot id: A0A8M9QA83
uniprot id: Q6PC76
names: Similarity
messages: Belongs to the GORASP family.

7955:mllt11
gene id: 7955:mllt11
uniprot id: A3KQS5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Cofactor for the transcription factor TCF7. May be involved in lymphoid development.
messages: Cytoplasm
messages: Nucleus
messages: Ubiquitinated, leading to degradation.
messages: centrosome

7955:LOC101885033
gene id: 7955:LOC101885033
uniprot id: A0A2R8PZG0
uniprot id: A0A8M2BFF1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:lsm7
gene id: 7955:lsm7
uniprot id: A4FVI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

7955:sema4bb
gene id: 7955:sema4bb
uniprot id: A0A8M9QCS6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cluha
gene id: 7955:cluha
uniprot id: A0A8M2B4F2
uniprot id: A0A8M2B4G7
uniprot id: A0A8M9QHB0
uniprot id: A0JMD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

7955:rnft2
gene id: 7955:rnft2
uniprot id: A0A0R4IZA5
uniprot id: A0A8M2BCC1
uniprot id: Q504D2
names: Subcellular Location Annotation
messages: Membrane

7955:sfpq
gene id: 7955:sfpq
uniprot id: Q6NUU2
names: Subcellular Location Annotation
messages: Nucleus speckle

7955:ndufa11
gene id: 7955:ndufa11
uniprot id: Q7SXE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

7955:thnsl1
gene id: 7955:thnsl1
uniprot id: A0A8M2B9Q7
names: Similarity
messages: Belongs to the threonine synthase family.

7955:ppl
gene id: 7955:ppl
uniprot id: A0A0R4IAS2
uniprot id: A0A286YAI4
uniprot id: A0A8M1NJ02
uniprot id: A0A8M2BBC1
names: Subcellular Location Annotation
messages: cytoskeleton

7955:rab38
gene id: 7955:rab38
uniprot id: A0A8M9PIV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

7955:atp6v0b
gene id: 7955:atp6v0b
uniprot id: A0A8M1P9M1
uniprot id: F1QYM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

7955:si:dkey-163m14.6
gene id: 7955:si:dkey-163m14.6
uniprot id: A0A8M9PD22
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:dspa
gene id: 7955:dspa
uniprot id: A0A8M1QL44
uniprot id: A0A8M2BID5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plakin or cytolinker family.
messages: Cell membrane
messages: Expressed in the periderm and enveloping layer between 6 hours post-fertilization (hpf) to 16 hpf. Expressed in the epidermis, otic vesicle, gut, neural tube, pharynx, pectoral fin, and olfactory organ from 1 to 5 dpf. Expressed in the lens and cardiac region at 6 hpf to 5 dpf.
messages: Involved in the organization of desmosome cell-cell junctions (PubMed:29522173). Of particular importance in cell adhesion in the skin and during cardiac development (PubMed:29522173). May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways (PubMed:29522173).
messages: Morpholino knockdowns show no general morphological differences however do show a slight developmental delay (PubMed:29522173). Abnormal skin surface, reduced numbers of desmosome cell-cell junctions and disorganization of remaining desmosome at 2 dpf (PubMed:29522173). Cardiac regions show reduced desmosome numbers, detached cells and pericardial effusion. Reduced resting heart rate (PubMed:29522173). A cardiac reduction in Wnt and TGF-beta signaling is also evident, with an increase in Hippo signaling (PubMed:29522173).
messages: cytoskeleton
messages: desmosome

7955:anxa2b
gene id: 7955:anxa2b
uniprot id: A8E5G1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Membrane
messages: basement membrane

7955:si
gene id: 7955:si
uniprot id: A0A8M6Z206
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rogdi
gene id: 7955:rogdi
uniprot id: Q7ZVT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Nucleus envelope
messages: Perikaryon
messages: Presynapse
messages: axon
messages: dendrite
messages: synaptic vesicle

7955:gpr25
gene id: 7955:gpr25
uniprot id: A0A2S1XYZ5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:slc39a1
gene id: 7955:slc39a1
uniprot id: P59889
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Mediates zinc uptake.
messages: Ubiquitous. Highest levels in ovary, high levels in heart, eye, kidney and brain, moderate levels in intestine and low levels in gill and skin.

7955:otub1a
gene id: 7955:otub1a
uniprot id: Q6DH16
names: Similarity
messages: Belongs to the peptidase C65 family.

7955:faim2b
gene id: 7955:faim2b
uniprot id: A0A140LGC1
uniprot id: A0A8M1PVB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7955:bco1
gene id: 7955:bco1
uniprot id: Q7ZTS0
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

7955:il15
gene id: 7955:il15
uniprot id: Q15KG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

7955:ndufaf5
gene id: 7955:ndufaf5
uniprot id: A3KP37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of ndufs7. May also have methyltransferase activity.
messages: Belongs to the methyltransferase superfamily.
messages: Mitochondrion inner membrane

7955:si:ch211-232d19.4
gene id: 7955:si:ch211-232d19.4
uniprot id: A0A8M3BBR1
uniprot id: Q1LY09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

7955:slc8b1
gene id: 7955:slc8b1
uniprot id: A0A8M9QHY2
names: Subcellular Location Annotation
messages: Membrane

7955:ift57
gene id: 7955:ift57
uniprot id: Q6IVW0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: Fishes show ciliary defects. In retina, cilia are generated but not maintained, producing the absence of photoreceptor outer segments. A loss of cilia also occurs in auditory hair cells and olfactory sensory neurons. In all 3 sense organs, cilia defects are followed by degeneration of sensory cells.
messages: Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro-apoptotic function.
messages: cilium basal body

7955:LOC100537401
gene id: 7955:LOC100537401
uniprot id: A0A8M9Q114
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:ccs
gene id: 7955:ccs
uniprot id: A0A8M1P2P3
uniprot id: F1QCS3
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

7955:gcfc2
gene id: 7955:gcfc2
uniprot id: A0A8M1NF35
uniprot id: A0A8M2B5M0
uniprot id: A0A8M2B5P2
names: Similarity
messages: Belongs to the GCF family.

7955:agap3
gene id: 7955:agap3
uniprot id: A0A8M3AW63
uniprot id: A0A8M3AZA0
uniprot id: A0A8M6YWA1
names: Similarity
messages: Belongs to the centaurin gamma-like family.

7955:edn2
gene id: 7955:edn2
uniprot id: A0A8M1NA55
uniprot id: Q1MT02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

7955:mfsd11
gene id: 7955:mfsd11
uniprot id: A0A8M2BGE8
uniprot id: Q4V9F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

7955:pde6h
gene id: 7955:pde6h
uniprot id: Q6PBP4
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

7955:sgut1
gene id: 7955:sgut1
uniprot id: Q5U3E4
names: Similarity
messages: Belongs to the SGT1 family.

7955:elnb
gene id: 7955:elnb
uniprot id: A0A8M1NAS7
uniprot id: A0A8M6YUG6
uniprot id: A0A8M6YV34
uniprot id: A0A8M6YWX5
uniprot id: A0A8M6Z2Z8
uniprot id: A0A8M6Z3N0
uniprot id: A0A8M9P3C9
uniprot id: A0A8M9PQI3
uniprot id: A0A8M9PTX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elastin family.
messages: extracellular matrix

7955:hoxa2b
gene id: 7955:hoxa2b
uniprot id: B3DGA4
uniprot id: O42365
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Proboscipedia subfamily.
messages: First expressed at the 2-somite stage as a stripe in the region of the hindbrain that will give rise to rhombomeres 2 and 3. By the 10-somite stage, expression has expanded posteriorly to rhombomeres 4 and 5.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:topaz1
gene id: 7955:topaz1
uniprot id: A0A0N4SUA6
uniprot id: A0A8M3AVW5
names: Function
names: Subcellular Location Annotation
messages: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
messages: cytosol

7955:vax2
gene id: 7955:vax2
uniprot id: B3DIR5
uniprot id: Q801E1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EMX homeobox family.
messages: By 7 somites, detected in the anterior brain and expression is strong within the optic stalks, preoptic area and telencephalon by 12 somites. By 16 somites, expression in the telencephalon is reduced but that in the preoptic area, optic stalk and ventral retina remains and this pattern of expression is similar at 24 hpf (hours post-fertilization). By 48 hpf, expression is restricted to the ventral preoptic area, anterior dorsal hypothalamus and ventral retina.
messages: Expressed in the anterior neural keel and later in the preoptic area, optic stalk and ventral retina.
messages: Nucleus
messages: Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup.

7955:uqcrh
gene id: 7955:uqcrh
uniprot id: Q3B750
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

7955:urgcp
gene id: 7955:urgcp
uniprot id: A0A8M9P1V9
uniprot id: A0A8M9PB17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:baiap2l2b
gene id: 7955:baiap2l2b
uniprot id: Q1LWE6
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures.
messages: The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).

7955:chrne
gene id: 7955:chrne
uniprot id: A2BG85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:tmem251
gene id: 7955:tmem251
uniprot id: Q5TZA3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Golgi apparatus membrane
messages: Knockout leads to severe developmental defects in zebrafish embryos, including heart edema, insufficient cartilage, and skeletal dysplasia.
messages: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes (PubMed:36096887). LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases (By similarity).

7955:ppm1bb
gene id: 7955:ppm1bb
uniprot id: A0A8M2B2A8
uniprot id: Q5U386
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

7955:kcnk3a
gene id: 7955:kcnk3a
uniprot id: A0A8M1N792
uniprot id: Q5TZ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:hccsa.2
gene id: 7955:hccsa.2
uniprot id: A0A8M6YUX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

7955:si:dkey-17e16.13
gene id: 7955:si:dkey-17e16.13
uniprot id: A0A8M1RP62
uniprot id: E9QH99
names: Subcellular Location Annotation
messages: Nucleus

7955:fbxw11a
gene id: 7955:fbxw11a
uniprot id: A0A2R8QFQ6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: At 4 days post fertilization (dpf), it is expressed at low levels in the retina and brain, and at higher levels in the jaw mesenchyme.
messages: Cytoplasm
messages: Knockdown of both fbxw11a and fbxw11b results in abnormally developed pectoral fins and heart edema by day 3 post-fertilization (3 dpf). At 5 dpf, knocked-down embryos show periocular edema, small and misshapen eyes, and abnormal development of the jaw.
messages: Nucleus
messages: Self-associates. Component of the SCF(FBXW11) complex.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Participates in Wnt signaling regulation, and plays a role in eye and jaw development (PubMed:31402090).
messages: The N-terminal D domain mediates homodimerization.

7955:elmo3
gene id: 7955:elmo3
uniprot id: A0A8M3APP6
uniprot id: A0A8M6Z4G1
uniprot id: F1QSV8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

7955:si:ch211-235o23.1
gene id: 7955:si:ch211-235o23.1
uniprot id: B0S728
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM71 family.
messages: Membrane

7955:mtmr1a
gene id: 7955:mtmr1a
uniprot id: A0A8M2BJN3
uniprot id: A0A8M2BJP1
uniprot id: A0A8M3B116
uniprot id: A0A8M3B3Y3
uniprot id: Q501S9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7955:jakmip2
gene id: 7955:jakmip2
uniprot id: A0A8M1QHM0
names: Similarity
messages: Belongs to the JAKMIP family.

7955:cdc34b
gene id: 7955:cdc34b
uniprot id: Q6DG18
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:hikeshi
gene id: 7955:hikeshi
uniprot id: Q568T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a specific nuclear import carrier for hsp70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound hsp70 proteins into the nucleus. hsp70 proteins import is required to protect cells from heat shock damages (By similarity).
messages: Belongs to the OPI10 family.
messages: Nucleus
messages: cytosol

7955:fam131ba
gene id: 7955:fam131ba
uniprot id: A0A8M3AKV0
uniprot id: A0A8M3AVE0
uniprot id: A0A8M3B3E2
uniprot id: A0A8M6YUQ2
uniprot id: A0A8M9P2A5
uniprot id: A0A8M9PBE9
uniprot id: F1QMB3
names: Similarity
messages: Belongs to the FAM131 family.

7955:rps28
gene id: 7955:rps28
uniprot id: Q6PBK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

7955:med4
gene id: 7955:med4
uniprot id: B2GPG1
uniprot id: Q561X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7955:ell
gene id: 7955:ell
uniprot id: Q6PEG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

7955:camsap1b
gene id: 7955:camsap1b
uniprot id: A0A8M2BFY1
uniprot id: A0A8M9Q3G5
uniprot id: A0A8M9QE25
uniprot id: A5WUN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMSAP1 family.
messages: Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to camsap2 and camsap3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation. Through interaction with spectrin may regulate neurite outgrowth.
messages: The CKK domain binds microtubules.
messages: cytoskeleton

7955:LOC100007467
gene id: 7955:LOC100007467
uniprot id: A0A8M6YZ46
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:cog2
gene id: 7955:cog2
uniprot id: Q7ZUD7
names: Similarity
messages: Belongs to the COG2 family.

7955:crygm2d2
gene id: 7955:crygm2d2
uniprot id: Q15I86
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:ccdc149a
gene id: 7955:ccdc149a
uniprot id: A0A8M6Z744
uniprot id: A0A8M9PNR9
uniprot id: Q5XJA2
names: Similarity
messages: Belongs to the CCDC149 family.

7955:sema3bl
gene id: 7955:sema3bl
uniprot id: A0A8N1Z0Q5
uniprot id: M9MM97
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zranb1a
gene id: 7955:zranb1a
uniprot id: A0A8M3BED9
names: Similarity
messages: Belongs to the peptidase C64 family.

7955:pkp3b
gene id: 7955:pkp3b
uniprot id: A0A8M1RDM4
uniprot id: F1QWE6
names: Similarity
messages: Belongs to the beta-catenin family.

7955:htr1d
gene id: 7955:htr1d
uniprot id: C0ITM0
uniprot id: F1QAQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:vps13d
gene id: 7955:vps13d
uniprot id: A0A8M9P5F9
uniprot id: A0A8M9PTG6
names: Similarity
messages: Belongs to the VPS13 family.

7955:tmcc3
gene id: 7955:tmcc3
uniprot id: A3KNG4
uniprot id: Q5RH38
names: Similarity
messages: Belongs to the TEX28 family.

7955:rrh
gene id: 7955:rrh
uniprot id: Q66I55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7955:ba1
gene id: 7955:ba1
uniprot id: B3DG37
uniprot id: Q90486
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from gills to the various peripheral tissues.
messages: Red blood cells.

7955:rbpjl
gene id: 7955:rbpjl
uniprot id: A0A8M9QBJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

7955:hmx3b
gene id: 7955:hmx3b
uniprot id: A0A8M6Z3N5
uniprot id: U3JAS7
names: Subcellular Location Annotation
messages: Nucleus

7955:tmem244
gene id: 7955:tmem244
uniprot id: A0A8M3AKK8
uniprot id: B7ZVF1
uniprot id: Q5RGR1
names: Subcellular Location Annotation
messages: Membrane

7955:pcdh2g1
gene id: 7955:pcdh2g1
uniprot id: I6LD66
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:nkd1
gene id: 7955:nkd1
uniprot id: A0A1I7Q3W8
uniprot id: A0A8M2BGA4
uniprot id: B0S7E2
uniprot id: Q2TJA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity).
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

7955:cyp2k20
gene id: 7955:cyp2k20
uniprot id: A0A8M9PP30
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:eif5a2
gene id: 7955:eif5a2
uniprot id: Q7ZUP4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

7955:ssbp4
gene id: 7955:ssbp4
uniprot id: A0A8M1NYZ2
uniprot id: F1QSI6
names: Subcellular Location Annotation
messages: Nucleus

7955:myt1a
gene id: 7955:myt1a
uniprot id: A0A8M3AYN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

7955:prepl
gene id: 7955:prepl
uniprot id: A0A8M1NRM5
uniprot id: A0A8M2B2W4
uniprot id: B8JJX2
names: Similarity
messages: Belongs to the peptidase S9A family.

7955:dock7
gene id: 7955:dock7
uniprot id: A0A8M1RR02
uniprot id: A0A8M2BD62
uniprot id: A0A8M2BD70
uniprot id: A0A8M2BD96
uniprot id: A0A8M9PMX0
uniprot id: A0A8M9PMX5
uniprot id: A0A8M9PMZ3
uniprot id: A0A8M9Q0M5
uniprot id: A0A8M9Q0N2
uniprot id: A0A8M9Q0P3
uniprot id: A0A8M9Q6X7
uniprot id: A0A8M9Q6Y2
uniprot id: A0A8M9Q6Y7
uniprot id: A0A8M9Q6Z5
uniprot id: A0A8M9QB36
uniprot id: A0A8M9QB41
uniprot id: A0A8M9QB50
uniprot id: A0A8M9QG48
uniprot id: A0A8M9QG53
uniprot id: A0A8M9QG61
uniprot id: A0A8M9QG66
names: Similarity
messages: Belongs to the DOCK family.

7955:hao1
gene id: 7955:hao1
uniprot id: A0A8M3AIM9
uniprot id: A4FVH7
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

7955:wisp3
gene id: 7955:wisp3
uniprot id: A0A8M6YUV4
uniprot id: D0E2W2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:si:ch1073-385f13.3
gene id: 7955:si:ch1073-385f13.3
uniprot id: A0A8M2BLG7
uniprot id: E7FAN2
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

7955:hbaa1
gene id: 7955:hbaa1
uniprot id: Q1JQ69
uniprot id: Q803Z5
uniprot id: Q90487
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from gills to the various peripheral tissues.
messages: Red blood cells.

7955:mysm1
gene id: 7955:mysm1
uniprot id: A0A8M9P2N0
uniprot id: Q5RGA4
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA (By similarity).
messages: Contaminating sequence. Potential poly-A sequence.
messages: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
messages: Nucleus

7955:aldh3a1
gene id: 7955:aldh3a1
uniprot id: A0A8M2B3W0
uniprot id: X1WBM4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7955:prr5a
gene id: 7955:prr5a
uniprot id: A0A8M1NZ01
uniprot id: E7F953
names: Similarity
messages: Belongs to the PROTOR family.

7955:ddah2
gene id: 7955:ddah2
uniprot id: A5PN62
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

7955:bmt2
gene id: 7955:bmt2
uniprot id: A0A8M3B785
uniprot id: Q0P410
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: Interacts with the GATOR1 complex; interaction is disrupted when bmt2/samtor binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when bmt2/samtor binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

7955:ak2
gene id: 7955:ak2
uniprot id: A0A0F6PK88
uniprot id: Q1L8L9
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Leads to aberrant leukocyte development.
messages: Mitochondrion intermembrane space
messages: Monomer.

7955:si:dkey-58f6.2
gene id: 7955:si:dkey-58f6.2
uniprot id: A0A8M6YZI1
uniprot id: E7FCB2
names: Similarity
messages: Belongs to the MDFI family.

7955:bmpr1ab
gene id: 7955:bmpr1ab
uniprot id: Q66HY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:ND3
gene id: 7955:ND3
uniprot id: Q9MIY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion inner membrane

7955:si:dkey-204a24.10
gene id: 7955:si:dkey-204a24.10
uniprot id: A0A8M1Q294
uniprot id: E7F219
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:LOC798736
gene id: 7955:LOC798736
uniprot id: A0A8M9PER5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:ivns1abpa
gene id: 7955:ivns1abpa
uniprot id: Q5RG82
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats.
messages: cytoskeleton

7955:trpv6
gene id: 7955:trpv6
uniprot id: F1QN56
uniprot id: Q6JQN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:xylt1
gene id: 7955:xylt1
uniprot id: D3J0E7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

7955:si:dkey-23a13.16
gene id: 7955:si:dkey-23a13.16
uniprot id: Q05AK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ccdc125
gene id: 7955:ccdc125
uniprot id: A2BGP7
names: Subcellular Location Annotation
messages: Cytoplasm

7955:adgrf3b
gene id: 7955:adgrf3b
uniprot id: A0A8N7UVY3
names: Subcellular Location Annotation
messages: Membrane

7955:ms4a17a.16
gene id: 7955:ms4a17a.16
uniprot id: Q0P3U8
names: Similarity
messages: Belongs to the MS4A family.

7955:ncoa3
gene id: 7955:ncoa3
uniprot id: A0A8M9QDK0
uniprot id: A0A8N7TE32
uniprot id: F1QMV7
names: Similarity
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.

7955:sulf2b
gene id: 7955:sulf2b
uniprot id: A0A8M3B5Z5
uniprot id: A0A8M6YXM3
uniprot id: A0A8M9P505
uniprot id: A0A8M9PKK2
uniprot id: A0A8M9PKK6
uniprot id: A0A8M9PSW4
uniprot id: Q6EF98
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7955:tead3b
gene id: 7955:tead3b
uniprot id: A0A8M2BDI0
uniprot id: A0A8M2BDI4
uniprot id: A0A8M2BDJ0
uniprot id: A0A8M2BDL1
uniprot id: A0A8M2BDM4
uniprot id: A0A8M2BDQ4
uniprot id: A7MBZ7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

7955:galnt6
gene id: 7955:galnt6
uniprot id: Q6NX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:tmsb
gene id: 7955:tmsb
uniprot id: Q1RM34
uniprot id: Q9W7M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

7955:foxc1b
gene id: 7955:foxc1b
uniprot id: Q9DE24
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine-induced endothelial cell migration. Plays a role in epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner.
messages: First detected at the shield stage of gastrulation in the involuting mesendoderm with levels being highest in the paraxial mesoderm and decline laterally to become undetectable in the ventral mesoderm. Expression spreads in the hypoblast towards the animal pole and converges dorsally. At the tail bud stage (9.5 hpf), transcripts are seen in adaxial cells flanking the future notochord and in the presomitic mesoderm (PSM). During early somitogenesis, expression also extends into the future head, in two stripes continuous with the adaxial cells. Expression continues under the hindbrain as far as the midbrain/hindbrain boundary, in the presomitic mesoderm (PSM), trunk adaxial cells and somites. Expression still found, in the early pharyngula stage. in the PSM and adaxial cells in the tail and, at 33 to 70 hpf, strong expression in the pharyngeal arches and saggital sections.
messages: Monomer.
messages: Nucleus

7955:mecp2
gene id: 7955:mecp2
uniprot id: A0A8M1P9C1
uniprot id: A8WIP2
uniprot id: Q7T2T7
names: Function
names: Subcellular Location Annotation
messages: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
messages: Nucleus

7955:tas2r201.2
gene id: 7955:tas2r201.2
uniprot id: A6P6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

7955:pts
gene id: 7955:pts
uniprot id: A5PKS5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

7955:galcb
gene id: 7955:galcb
uniprot id: Q7ZUD5
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

7955:letm2
gene id: 7955:letm2
uniprot id: A0A8M1PZB6
uniprot id: F1QSQ8
names: Subcellular Location Annotation
messages: Membrane

7955:vamp2
gene id: 7955:vamp2
uniprot id: Q6PBQ1
uniprot id: Q7SZZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane

7955:or106-9
gene id: 7955:or106-9
uniprot id: Q2PRK8
names: Subcellular Location Annotation
messages: Membrane

7955:LOC560863
gene id: 7955:LOC560863
uniprot id: A0A8M6YWR1
uniprot id: A0A8M9PH57
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:barhl2
gene id: 7955:barhl2
uniprot id: Q6YI96
names: Subcellular Location Annotation
messages: Nucleus

7955:pknox2
gene id: 7955:pknox2
uniprot id: Q8AYN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

7955:hoxd13a
gene id: 7955:hoxd13a
uniprot id: B0S5Z0
uniprot id: Q90472
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: First expressed at 15 hours post-fertilization (hpf) in the presumptive proctodeum. At 22 hpf, expressed in the most distal part of the hindgut, the future rectum and the cloacal region; cloacal expression is still detectable until 64 hpf. First detected in the dorsal pre-somitic mesoderm and neural keel at 17 hpf. At 22-26 hpf, expression is restricted to the posterior tip of the trunk, begins to weaken and is undetectable by 40-56 hpf.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:camk1b
gene id: 7955:camk1b
uniprot id: A0A8M1PRX0
uniprot id: A0A8M9QHV1
uniprot id: E7F1H0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:taf4a
gene id: 7955:taf4a
uniprot id: A0A8M1QUY2
uniprot id: A0A8M2BK83
uniprot id: E7FBZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

7955:pigp
gene id: 7955:pigp
uniprot id: A0A2R8Q1D2
uniprot id: A0A8M1PBS0
uniprot id: A0A8M2BJV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

7955:csad
gene id: 7955:csad
uniprot id: A0A8M3B6C7
uniprot id: B2GQC8
uniprot id: F1QG14
uniprot id: Q5U3I6
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

7955:LOC101885478
gene id: 7955:LOC101885478
uniprot id: A0A8M6Z3G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

7955:ighmbp2
gene id: 7955:ighmbp2
uniprot id: A0A8M1N9K7
uniprot id: M9MM98
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

7955:si:dkeyp-110c12.3
gene id: 7955:si:dkeyp-110c12.3
uniprot id: A0A8M3AWK5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

7955:snx8b
gene id: 7955:snx8b
uniprot id: A0A0R4IDN5
uniprot id: A0A8M3AY83
uniprot id: A0A8M9PX28
names: Subcellular Location Annotation
messages: Membrane

7955:celf2
gene id: 7955:celf2
uniprot id: A0A8M6Z5W1
uniprot id: A0A8M9PH20
uniprot id: A0A8M9PH22
uniprot id: A0A8M9PH27
uniprot id: A0A8M9PH30
uniprot id: A0A8M9PH35
uniprot id: A0A8M9PU80
uniprot id: A0A8M9PU86
uniprot id: A0A8M9PU91
uniprot id: A0A8M9PU94
uniprot id: A0A8M9PU99
uniprot id: A0A8M9Q087
uniprot id: A0A8M9Q092
uniprot id: A0A8M9Q097
uniprot id: A0A8M9Q0A2
uniprot id: A0A8M9Q5S6
uniprot id: A0A8M9Q5S8
uniprot id: A0A8M9Q5T1
uniprot id: A0A8M9Q5T3
uniprot id: A0A8M9QB04
uniprot id: A0A8M9QB09
uniprot id: A0A8M9QB14
uniprot id: A0A8M9QB19
uniprot id: A0A8M9QB24
uniprot id: Q4U0V5
uniprot id: Q6P0B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in pre-mRNA alternative splicing, mRNA translation repression and stability (By similarity).

7955:nif3l1
gene id: 7955:nif3l1
uniprot id: Q4KMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

7955:elmo1
gene id: 7955:elmo1
uniprot id: A0A0R4IHP8
uniprot id: A0A2R8RS12
uniprot id: A0A8M3ASM3
uniprot id: A0A8M3ASM6
uniprot id: A0A8M3B3L5
uniprot id: A0A8M6YUG7
uniprot id: Q6NV39
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

7955:acox3
gene id: 7955:acox3
uniprot id: Q7T2B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

7955:zeb2b
gene id: 7955:zeb2b
uniprot id: A0A8M9QAF0
uniprot id: B0LVF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
messages: Nucleus

7955:akap9
gene id: 7955:akap9
uniprot id: A0A8M9PS32
names: Subcellular Location Annotation
messages: centrosome

7955:irx1b
gene id: 7955:irx1b
uniprot id: Q90YN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7955:gpr173
gene id: 7955:gpr173
uniprot id: Q9I918
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (By similarity). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (By similarity).

7955:zmp:0000000912
gene id: 7955:zmp:0000000912
uniprot id: A0A8M9Q3R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

7955:si:dkeyp-4h4.1
gene id: 7955:si:dkeyp-4h4.1
uniprot id: A0A8M6Z4C3
names: Subcellular Location Annotation
messages: Membrane

7955:snx17
gene id: 7955:snx17
uniprot id: A0A0R4ITX6
uniprot id: A0A8M3B409
uniprot id: Q5RID7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sorting nexin family.
messages: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane
messages: Monomer (By similarity). Interacts with CCDC22, CCDC93, DSCR3 and VPS35L; the interaction with DSCR3 is direct and associates SNX17 with the retriever and CCC complexes (By similarity).
messages: The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.
messages: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.

7955:tmtops2a
gene id: 7955:tmtops2a
uniprot id: A0A0N9NVU5
uniprot id: R9R6C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

7955:pik3r3b
gene id: 7955:pik3r3b
uniprot id: A0A8M2BDR6
uniprot id: A0A8M9PLR5
uniprot id: Q66I41
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

7955:pik3c2b
gene id: 7955:pik3c2b
uniprot id: F1QWN6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:LOC101884616
gene id: 7955:LOC101884616
uniprot id: A0A8M9QIR9
names: Subcellular Location Annotation
messages: Nucleus

7955:lifrb
gene id: 7955:lifrb
uniprot id: A0A8M3ATV3
uniprot id: A8WH83
uniprot id: F1Q5F5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

7955:fdft1
gene id: 7955:fdft1
uniprot id: A0A0R4IVV5
uniprot id: A0A8M1P1T1
uniprot id: A0A8M9PPK1
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

7955:rbm10
gene id: 7955:rbm10
uniprot id: A0A8M3AMK0
uniprot id: A0A8M3ANB8
uniprot id: A0A8M3AV06
uniprot id: A0A8M3AY14
uniprot id: F1R9N7
names: Subcellular Location Annotation
messages: Nucleus

7955:prpf38b
gene id: 7955:prpf38b
uniprot id: A0A8M2BIP6
uniprot id: A0A8M2BIS8
uniprot id: A0A8M3AXI1
uniprot id: Q6P7Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

7955:zgc:101783
gene id: 7955:zgc:101783
uniprot id: A0A8M2BA18
uniprot id: A0A8M2BA50
uniprot id: F1R0K5
uniprot id: Q66IC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

7955:spata6l
gene id: 7955:spata6l
uniprot id: Q7T2B2
names: Similarity
messages: Belongs to the SPATA6 family.

7955:lhx2a
gene id: 7955:lhx2a
uniprot id: A0A8M1NRD6
uniprot id: A0A8M6YWY7
uniprot id: E9QBI8
uniprot id: F1R0M6
names: Subcellular Location Annotation
messages: Nucleus

7955:tas2r201.1
gene id: 7955:tas2r201.1
uniprot id: Q2AB30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

7955:xkr7
gene id: 7955:xkr7
uniprot id: Q32PW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:taar18g
gene id: 7955:taar18g
uniprot id: A0A8M3BDC1
uniprot id: A0A8M9PUF0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:grid1b
gene id: 7955:grid1b
uniprot id: A0A8M3AY56
uniprot id: A0A8M9QMU9
uniprot id: A0A8N7TDB2
uniprot id: R4GDN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:slc4a10b
gene id: 7955:slc4a10b
uniprot id: A0A8M1RNL2
uniprot id: A0A8M9QG81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

7955:serpinf2b
gene id: 7955:serpinf2b
uniprot id: A1A5Y8
names: Similarity
messages: Belongs to the serpin family.

7955:crx
gene id: 7955:crx
uniprot id: Q8JIZ3
names: Subcellular Location Annotation
messages: Nucleus

7955:fbxl7
gene id: 7955:fbxl7
uniprot id: A1A5X2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBXL7 family.
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7).
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
messages: centrosome

7955:tmco3
gene id: 7955:tmco3
uniprot id: A0A8M9PJF7
names: Subcellular Location Annotation
messages: Membrane

7955:tnip2
gene id: 7955:tnip2
uniprot id: A0A8N7TE24
uniprot id: F1QDJ2
names: Subcellular Location Annotation
messages: Cytoplasm

7955:apoa4b.2
gene id: 7955:apoa4b.2
uniprot id: A0A8M9NZC6
uniprot id: B3DHC5
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

7955:rfx1a
gene id: 7955:rfx1a
uniprot id: A0A8M2BB37
uniprot id: A0A8M9P3K7
uniprot id: A0A8M9PUE2
uniprot id: A4QP58
names: Subcellular Location Annotation
messages: Nucleus

7955:cadm4
gene id: 7955:cadm4
uniprot id: A0A8M2B4F3
uniprot id: A0A8M2B4X9
uniprot id: B0CLV3
uniprot id: Q5U3R8
names: Similarity
messages: Belongs to the nectin family.

7955:abi2a
gene id: 7955:abi2a
uniprot id: A0A0R4IWX6
uniprot id: A0A8M2BEV6
uniprot id: A0A8M2BEZ1
uniprot id: A0A8M3AVS9
uniprot id: A0A8M3AVT6
uniprot id: A0A8M3B5F6
uniprot id: A0A8M3BCB1
uniprot id: A0A8M6Z2K8
uniprot id: A0A8M6Z8H2
uniprot id: A0A8M9PSC7
uniprot id: A0A8M9Q4Q3
uniprot id: A0A8M9QAY1
uniprot id: B0V218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

7955:p2ry2.1
gene id: 7955:p2ry2.1
uniprot id: A0A8N7T8P0
uniprot id: E7FEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:ncbp3
gene id: 7955:ncbp3
uniprot id: Q803E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export.
messages: Belongs to the NCBP3 family.
messages: Component of an alternative cap-binding complex (CBC) composed of NCBP1/CBP80 and NCBP3.
messages: Cytoplasm
messages: Nucleus

7955:lamc1
gene id: 7955:lamc1
uniprot id: Q1LVF0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
messages: basement membrane

7955:prdm1c
gene id: 7955:prdm1c
uniprot id: A0A8M6Z3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

7955:tnfrsf21
gene id: 7955:tnfrsf21
uniprot id: A5D8S6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:or125-7
gene id: 7955:or125-7
uniprot id: Q2PRA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:uckl1a
gene id: 7955:uckl1a
uniprot id: A0A8M1NH97
uniprot id: A0A8M2BF24
uniprot id: B0S7A4
names: Similarity
messages: Belongs to the uridine kinase family.

7955:sdhdb
gene id: 7955:sdhdb
uniprot id: Q68FN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b560 composed of sdhc and sdhd.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

7955:si:ch73-380l10.2
gene id: 7955:si:ch73-380l10.2
uniprot id: A0A0R4ILT6
uniprot id: A0A387J5F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

7955:zgc:158446
gene id: 7955:zgc:158446
uniprot id: A2VD28
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:lgi1a
gene id: 7955:lgi1a
uniprot id: F6NUE1
uniprot id: Q2HPG2
names: Subcellular Location Annotation
messages: Secreted

7955:il13ra1
gene id: 7955:il13ra1
uniprot id: A8WH86
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

7955:lyrm2
gene id: 7955:lyrm2
uniprot id: Q5RIM0
names: Similarity
messages: Belongs to the complex I LYR family.

7955:desi1a
gene id: 7955:desi1a
uniprot id: Q6PC81
names: Similarity
messages: Belongs to the DeSI family.

7955:tmem41ab
gene id: 7955:tmem41ab
uniprot id: A0A8M9PS30
uniprot id: Q6NV38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

7955:dlx2b
gene id: 7955:dlx2b
uniprot id: A4IG28
uniprot id: Q98876
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

7955:arhgef1b
gene id: 7955:arhgef1b
uniprot id: A0A8M1N9P8
uniprot id: A0A8M6YTG6
uniprot id: A0A8M9NZA7
uniprot id: A0A8M9P7X5
uniprot id: A0A8M9P7X6
uniprot id: A0A8M9PD45
uniprot id: A0A8M9PD48
uniprot id: A0A8M9PJI2
uniprot id: A0A8M9PJI7
uniprot id: A0A8M9PMH2
uniprot id: A0A8M9PMH6
uniprot id: F1Q4Y0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

7955:si:dkey-114g7.4
gene id: 7955:si:dkey-114g7.4
uniprot id: A0A8M1NBU8
uniprot id: Q1L8N6
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

7955:foxl2
gene id: 7955:foxl2
uniprot id: Q1JPV2
names: Subcellular Location Annotation
messages: Nucleus

7955:foxred2
gene id: 7955:foxred2
uniprot id: B0UXS1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FOXRED2 family.
messages: Endoplasmic reticulum lumen
messages: N-glycosylated.
messages: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity).

7955:thoc6
gene id: 7955:thoc6
uniprot id: Q5XJS5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity).
messages: Belongs to the WD repeat THOC6 family.
messages: Component of the THO subcomplex of the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
messages: Highly expressed in the developing midbrain and the eyes at 24 hpf. The expression becomes restricted afterwards to the posterior part of the midbrain and the midbrain-hindbrain boundary.
messages: Nucleus
messages: Nucleus speckle

7955:rplp2
gene id: 7955:rplp2
uniprot id: A0A8M9PZH4
uniprot id: Q6PBJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.
messages: Plays an important role in the elongation step of protein synthesis.

7955:hsf2
gene id: 7955:hsf2
uniprot id: Q90XA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

7955:tceanc2
gene id: 7955:tceanc2
uniprot id: B0UYI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCEANC2 family.
messages: Nucleus

7955:cyb5r3
gene id: 7955:cyb5r3
uniprot id: Q6NYE6
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

7955:ssh1b
gene id: 7955:ssh1b
uniprot id: A0A8M9QEN9
uniprot id: A0A8N7UVI6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

7955:opn1lw2
gene id: 7955:opn1lw2
uniprot id: Q8AYN0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

7955:zgc:123299
gene id: 7955:zgc:123299
uniprot id: A0A8M9PSY7
uniprot id: Q32LT5
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:hdhd2
gene id: 7955:hdhd2
uniprot id: A0A8M6Z1A7
uniprot id: F1QJW5
uniprot id: Q5BJJ5
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Binds 1 Mg(2+) ion per subunit.

7955:tmem8a
gene id: 7955:tmem8a
uniprot id: A0A8M1NQ21
uniprot id: A0A8M2BI41
uniprot id: B8A5M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

7955:rell2
gene id: 7955:rell2
uniprot id: Q1RLT5
names: Similarity
messages: Belongs to the RELT family.

7955:ufd1l
gene id: 7955:ufd1l
uniprot id: Q6DRD5
names: Similarity
messages: Belongs to the UFD1 family.

7955:chsy1
gene id: 7955:chsy1
uniprot id: Q6P296
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7955:dpysl5a
gene id: 7955:dpysl5a
uniprot id: Q52PJ7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

7955:hck
gene id: 7955:hck
uniprot id: A0A0R4J755
uniprot id: A0A8M2BLR4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:brox
gene id: 7955:brox
uniprot id: A3KQV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BROX family.
messages: Membrane

7955:tsc22d2
gene id: 7955:tsc22d2
uniprot id: A0A2R8RWC4
uniprot id: A0A8M3B5S8
uniprot id: Q6TEL2
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

7955:nme2b.1
gene id: 7955:nme2b.1
uniprot id: A0A8M6Z292
uniprot id: Q9IAD3
names: Similarity
messages: Belongs to the NDK family.

7955:ccdc153
gene id: 7955:ccdc153
uniprot id: A8KB59
names: Similarity
messages: Belongs to the UPF0610 family.

7955:si:dkey-202e22.2
gene id: 7955:si:dkey-202e22.2
uniprot id: A0A8N7UQX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:dkey-103j14.5
gene id: 7955:si:dkey-103j14.5
uniprot id: A0A8M2B339
uniprot id: F1R0Q9
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

7955:nt5c2l1
gene id: 7955:nt5c2l1
uniprot id: A0A8M9PTI8
uniprot id: A0A8M9QGL3
uniprot id: Q66I11
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

7955:mapk7
gene id: 7955:mapk7
uniprot id: A0A8M2B237
uniprot id: E9QEY0
uniprot id: Q0H1F4
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

7955:buc
gene id: 7955:buc
uniprot id: H0WFA5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cleavage furrow
messages: Cytoplasm
messages: Expressed exclusively in the ovary, and protein localizes to the Balbiani body during oogenesis and with the germ plasm during early embryogenesis (PubMed:19249209). Accumulates at embryonic cleavage furrows (PubMed:26253407).
messages: Mutant fails to form Balbiani body, and vegetal mRNAs are not localized in oocytes.
messages: Prion-like protein required for the formation of Balbiani body (electron-dense aggregates in the oocyte) and germ plasm assembly, and for the establishment of oocyte polarity during early oogenesis (PubMed:18582455, PubMed:19249209). Mobility and aggregation properties are improved by tudor domain-containing protein tdrd6 through interaction with dimethylated arginines Tri-RG domains (PubMed:30086300). Establishes oocyte polarity through interactions with RNA-binding proteins rbpms2 and dazl, initiating a positive feedback loop amplification mechanism in the Balbiani body (PubMed:24496621). Interaction of BUC protein and mRNA with rbpms2 and dazl is required to mediate Balbiani body formation (PubMed:24496621). Involved in recruitment of germ plasm to embryonic cleavage furrows and dorsoventral patterning through interaction with Kinesin-1/KIF5BA (PubMed:26253407).
messages: Specifically interacts (when methylated) with tdrd6 (via Tudor domain); interaction is responsible for recruitment of different protein complexes to germ plasm (PubMed:30086300). Interacts with rbpms2 and dazl; interaction mediates Balbiani body formation (PubMed:24496621). Interacts with kif5ba; interaction leads to buc enrichment at the embryonic cleavage furrows and mediates dorsoventral patterning (PubMed:26253407).
messages: Symmetric dimethylarginine modification promotes interaction with tdrd6.
messages: The dimethylated RG motifs (RG[X0-4]RG[X0-4]RG) motif mediates interaction with TDRD6 and is required for Balbiani body formation.

7955:urad
gene id: 7955:urad
uniprot id: A1L259
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
messages: Homodimer.
messages: Peroxisome

7955:LOC101886077
gene id: 7955:LOC101886077
uniprot id: A0A8M3ARS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

7955:ube2g2
gene id: 7955:ube2g2
uniprot id: Q567F7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:igfbp6a
gene id: 7955:igfbp6a
uniprot id: C4MCP0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:or111-7
gene id: 7955:or111-7
uniprot id: Q9PSU4
names: Subcellular Location Annotation
messages: Membrane

7955:sirt5
gene id: 7955:sirt5
uniprot id: A0A8M2BHG7
uniprot id: Q6DHI5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-70 and Arg-73) that bind to malonylated and succinylated substrates and define the specificity.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-98 and Arg-101) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
messages: Nucleus
messages: cytosol

7955:kif5ba
gene id: 7955:kif5ba
uniprot id: A0A8M2BJ79
uniprot id: A0A8N7UUZ8
uniprot id: F1R5M2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:saraf
gene id: 7955:saraf
uniprot id: A0A8M2B6M4
uniprot id: F1QPC3
uniprot id: J9PBQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (stim1 or stim2)-dependent SOCE activity (By similarity).

7955:babam1
gene id: 7955:babam1
uniprot id: Q6AXK4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM1 family.
messages: Component of the ARISC complex, at least composed of uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and babam1/nba1. Component of the BRCA1-A complex, at least composed of brca1, bard1, uimc1/rap80, abraxas1, brcc3/brcc36, babam2 and babam1/nba1. In the BRCA1-A complex, interacts directly with abraxas1 and babam2. Component of the BRISC complex, at least composed of abraxas2, brcc3/brcc36, babam2 and babam1/nba1.
messages: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of babam2 and help the 'Lys-63'-linked deubiquitinase activity mediated by brcc3/brcc36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.
messages: Cytoplasm
messages: Nucleus
messages: The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.

7955:cdc25d
gene id: 7955:cdc25d
uniprot id: A0A8M6Z595
uniprot id: B5LY74
names: Similarity
messages: Belongs to the MPI phosphatase family.

7955:fep15
gene id: 7955:fep15
uniprot id: A0A8M1NW48
names: Similarity
messages: Belongs to the selenoprotein M/F family.

7955:casc4
gene id: 7955:casc4
uniprot id: A0A1D5NSL0
uniprot id: A0A8M2BG87
uniprot id: A0A8N7UUL7
uniprot id: E7FBP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

7955:uchl3
gene id: 7955:uchl3
uniprot id: B2GPF3
uniprot id: Q504C0
names: Similarity
messages: Belongs to the peptidase C12 family.

7955:mdh1ab
gene id: 7955:mdh1ab
uniprot id: Q7ZSY2
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

7955:mpp3b
gene id: 7955:mpp3b
uniprot id: A0A8M3AY60
uniprot id: A0A8M3BE30
uniprot id: A0A8M6Z3K2
uniprot id: A0A8M9QEM4
uniprot id: E7F7X1
names: Similarity
messages: Belongs to the MAGUK family.

7955:sbno2a
gene id: 7955:sbno2a
uniprot id: D6RUV4
names: Similarity
messages: Belongs to the SBNO family.

7955:rce1b
gene id: 7955:rce1b
uniprot id: A0A8M6YUR9
uniprot id: A0A8M6YVA7
uniprot id: A0A8M6YX55
uniprot id: A0A8M6Z385
uniprot id: A0A8M6Z3W7
uniprot id: A0A8M9PIY1
uniprot id: A0A8M9PUN5
uniprot id: A0A8N7UTA9
uniprot id: E9QGI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:grb2a
gene id: 7955:grb2a
uniprot id: Q5RKN6
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

7955:dus4l
gene id: 7955:dus4l
uniprot id: A0A8M1N156
uniprot id: Q5RIX6
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

7955:si:dkey-118j18.1
gene id: 7955:si:dkey-118j18.1
uniprot id: A0A8N7UVT2
uniprot id: E7F4T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

7955:tbc1d24
gene id: 7955:tbc1d24
uniprot id: A0A8M1RN56
uniprot id: A0A8M3B6W1
uniprot id: A0A8M9PMI2
names: Subcellular Location Annotation
messages: Membrane

7955:dgcr6
gene id: 7955:dgcr6
uniprot id: Q6TH21
names: Similarity
messages: Belongs to the gonadal family.

7955:ankrd13c
gene id: 7955:ankrd13c
uniprot id: Q7ZUV0
names: Function
names: Subcellular Location Annotation
messages: Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
messages: Endoplasmic reticulum membrane

7955:ptch1
gene id: 7955:ptch1
uniprot id: A0A8M1P6A6
uniprot id: F1R8E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

7955:polr2eb
gene id: 7955:polr2eb
uniprot id: Q6DEG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

7955:zgc:85777
gene id: 7955:zgc:85777
uniprot id: Q6NWF0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7955:olfcd3
gene id: 7955:olfcd3
uniprot id: A0A8N7T7X6
uniprot id: F1QS61
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:arhgap32a
gene id: 7955:arhgap32a
uniprot id: A0A8N7TEW2
uniprot id: F1RDK4
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

7955:si:ch211-130m23.3
gene id: 7955:si:ch211-130m23.3
uniprot id: A0A8M3B9V2
uniprot id: A0A8M6Z6W7
uniprot id: A2BIP9
uniprot id: A8WG20
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC798694
gene id: 7955:LOC798694
uniprot id: A0A8M6Z3V5
uniprot id: A0A8M9PIV7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:crygm2f
gene id: 7955:crygm2f
uniprot id: A8KBB6
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:mical1
gene id: 7955:mical1
uniprot id: E5F2M3
uniprot id: E7F9T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm
messages: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and prevent repolymerization.
messages: cytoskeleton

7955:calm1b
gene id: 7955:calm1b
uniprot id: Q6PI52
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

7955:si:dkey-283b15.2
gene id: 7955:si:dkey-283b15.2
uniprot id: A0A8N7UVM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC101887189
gene id: 7955:LOC101887189
uniprot id: A0A8M9P707
names: Subcellular Location Annotation
messages: Nucleus

7955:alg11
gene id: 7955:alg11
uniprot id: A0A2R8QEZ2
uniprot id: A0A8M1P0R5
uniprot id: F1R333
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

7955:fam46ab
gene id: 7955:fam46ab
uniprot id: A7MBZ2
names: Similarity
messages: Belongs to the TENT family.

7955:pcna
gene id: 7955:pcna
uniprot id: Q9PTP1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity). Component of the replisome complex (By similarity).
messages: Monoubiquitinated by the ube2b-rad18 complex on Lys-164. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the dcx(dtl) complex, leading to enhance PCNA-dependent translesion DNA synthesis (By similarity).
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

7955:tm2d2
gene id: 7955:tm2d2
uniprot id: Q6DHN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

7955:nme6
gene id: 7955:nme6
uniprot id: A0A8M9PHJ1
uniprot id: Q6DI51
names: Function
names: Similarity
messages: Belongs to the NDK family.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

7955:or118-3
gene id: 7955:or118-3
uniprot id: Q2PRD8
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch211-141o9.10
gene id: 7955:si:ch211-141o9.10
uniprot id: E7FBZ9
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

7955:si:dkey-108k21.15
gene id: 7955:si:dkey-108k21.15
uniprot id: Q561S9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:snap25b
gene id: 7955:snap25b
uniprot id: Q6PC54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Expressed in several regions throughout the adult brain, including the mesencephalon.
messages: May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
messages: synaptosome

7955:tmem205
gene id: 7955:tmem205
uniprot id: A1L2F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

7955:waplb
gene id: 7955:waplb
uniprot id: A0A8M9QEL9
names: Similarity
messages: Belongs to the WAPL family.

7955:irgq2
gene id: 7955:irgq2
uniprot id: B3DHG4
uniprot id: Q1LY91
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

7955:LOC100007535
gene id: 7955:LOC100007535
uniprot id: A0A8M9QHZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

7955:cdc123
gene id: 7955:cdc123
uniprot id: A0A8M3AYH2
uniprot id: Q6PC40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Required for S phase entry of the cell cycle.

7955:xgb
gene id: 7955:xgb
uniprot id: A3KNI8
names: Similarity
messages: Belongs to the globin family.

7955:mvda
gene id: 7955:mvda
uniprot id: Q5U403
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Was originally thought to be located in the peroxisome. However, was later shown to be cytosolic.

7955:usp5
gene id: 7955:usp5
uniprot id: Q1MT86
uniprot id: Q4V973
names: Similarity
messages: Belongs to the peptidase C19 family.

7955:mep1a.2
gene id: 7955:mep1a.2
uniprot id: B3DKP9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:fam57bb
gene id: 7955:fam57bb
uniprot id: A0A8M2B2L9
uniprot id: E7FG14
names: Subcellular Location Annotation
messages: Membrane

7955:kat6a
gene id: 7955:kat6a
uniprot id: A2CG09
uniprot id: B3DK06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

7955:npm1b
gene id: 7955:npm1b
uniprot id: A0A8M1NVF2
uniprot id: A0A8M2BKD3
uniprot id: Q566X7
names: Similarity
messages: Belongs to the nucleoplasmin family.

7955:coq3
gene id: 7955:coq3
uniprot id: Q6DHK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

7955:rprd1b
gene id: 7955:rprd1b
uniprot id: A0A8M2B9C0
uniprot id: A0A8M2B9C1
uniprot id: A0A8M2B9L5
uniprot id: Q7ZUK9
names: Similarity
messages: Belongs to the UPF0400 (RTT103) family.

7955:doc2b
gene id: 7955:doc2b
uniprot id: A0A8M3ASV5
names: Subcellular Location Annotation
messages: Membrane

7955:uap1l1
gene id: 7955:uap1l1
uniprot id: Q7ZWD4
names: Similarity
messages: Belongs to the UDPGP type 1 family.

7955:snupn
gene id: 7955:snupn
uniprot id: A0A8M9P6D1
uniprot id: Q6P5J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

7955:izumo1
gene id: 7955:izumo1
uniprot id: A0A2R8QHQ6
uniprot id: A0A8M1P314
names: Similarity
messages: Belongs to the Izumo family.

7955:cavin2b
gene id: 7955:cavin2b
uniprot id: A0A8M1N248
uniprot id: F1R665
uniprot id: Q66HY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

7955:hagh
gene id: 7955:hagh
uniprot id: A0A8M9PEU7
uniprot id: Q6P963
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Only one single gene encoding glyoxalase II has been identified in vertebrates. In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II.
messages: Produced by alternative initiation at Met-44 of isoform 1. Alternative initiation has been proven in human.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

7955:wdr55
gene id: 7955:wdr55
uniprot id: Q6DRF9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Death between 10 and 12 dpf. Thymus size is remarkably reduced and the pharyngeal arches are malformed. Eyes and swim bladder are also reduced.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).
messages: nucleolus

7955:lipca
gene id: 7955:lipca
uniprot id: Q7T359
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:opn8b
gene id: 7955:opn8b
uniprot id: A0A0N9NW90
uniprot id: A0A8M9PSX7
uniprot id: F1QCL1
names: Subcellular Location Annotation
messages: Membrane

7955:ppme1
gene id: 7955:ppme1
uniprot id: Q7ZV37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

7955:asrgl1
gene id: 7955:asrgl1
uniprot id: B2GNT8
uniprot id: Q5BKW9
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal and deformed fish at 6 dpf.
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.
messages: Cytoplasm
messages: Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
messages: Heterodimer of an alpha and beta chain produced by autocleavage.

7955:cyp27a1.4
gene id: 7955:cyp27a1.4
uniprot id: A0A8M1P998
uniprot id: A0A8M3B2U5
uniprot id: F1QAE0
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:dok4
gene id: 7955:dok4
uniprot id: A0A8N7TFC9
uniprot id: E7F0P2
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

7955:arsg
gene id: 7955:arsg
uniprot id: A4QP89
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7955:fam110b
gene id: 7955:fam110b
uniprot id: F1R180
uniprot id: Q4QRD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM110 family.
messages: Cytoplasm
messages: centrosome

7955:epx
gene id: 7955:epx
uniprot id: A0A8M9PHJ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:klhl41a
gene id: 7955:klhl41a
uniprot id: E9QIN8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in skeletal muscle development and differentiation.
messages: Morphants exhibit leaner bodies, smaller eyes, and pericardial edema. At 3 dpf morphants show reduced birefringence in axial skeletal muscles suggesting disorganized skeletal muscle structure.
messages: Sarcoplasmic reticulum membrane
messages: Ubiquitous expression during early development at 1 dpf, but by 2 dpf, transcripts are virtually undetectable in the major axial skeletal muscles.
messages: cytoskeleton

7955:snx30
gene id: 7955:snx30
uniprot id: Q566W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Together with snx4, involved in autophagosome assembly.

7955:zgc:112102
gene id: 7955:zgc:112102
uniprot id: B2GTL1
uniprot id: Q502J7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Member of the pointed-end complex of the dynactin shoulder complex which contains dctn4, dctn5 and dctn6 subunits and Actr10. Within the complex dctn6 forms a heterodimer with dctn5. Interacts with plk1 (By similarity).
messages: cytoskeleton
messages: kinetochore

7955:cdca9
gene id: 7955:cdca9
uniprot id: A0A8M1NYY3
uniprot id: F1QB27
uniprot id: U3JAU5
names: Similarity
messages: Belongs to the borealin family.

7955:rtn2b
gene id: 7955:rtn2b
uniprot id: A0A8M2B839
uniprot id: A0A8M9PQI6
uniprot id: Q4G5T7
names: Caution
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:senp3a
gene id: 7955:senp3a
uniprot id: A0A8M9QE82
uniprot id: A2BEN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

7955:cfap206
gene id: 7955:cfap206
uniprot id: A0A8M3AKL8
uniprot id: A0A8M3AT00
uniprot id: A2RV06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (By similarity).
messages: cilium axoneme
messages: cilium basal body

7955:cav3
gene id: 7955:cav3
uniprot id: B2GQW4
uniprot id: Q6YLH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola
messages: sarcolemma

7955:si:dkey-3n22.9
gene id: 7955:si:dkey-3n22.9
uniprot id: A0A8M9P2A8
names: Similarity
messages: Belongs to the peptidase C48 family.

7955:epg5
gene id: 7955:epg5
uniprot id: A0A8M2BCV4
uniprot id: A0A8M3ASP3
uniprot id: A5WUT8
names: Function
names: Similarity
messages: Belongs to the EPG5 family.
messages: Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity).

7955:LOC108183844
gene id: 7955:LOC108183844
uniprot id: A0A8M6YXN4
names: Similarity
messages: Belongs to the NLRP family.

7955:kif1b
gene id: 7955:kif1b
uniprot id: A0A8M1PES2
uniprot id: A0A8M2B951
uniprot id: A0A8M3AMT9
uniprot id: A0A8M3AMU4
uniprot id: A0A8M3AMU7
uniprot id: A0A8M3AMV0
uniprot id: A0A8M3ANK1
uniprot id: A0A8M3ANK4
uniprot id: A0A8M3ANK7
uniprot id: A0A8M3ANL2
uniprot id: A0A8M3AV93
uniprot id: A0A8M3AV98
uniprot id: A0A8M3AVA2
uniprot id: A0A8M3AVA7
uniprot id: A0A8M3AYB6
uniprot id: A0A8M3AYB9
uniprot id: A0A8M3AYC4
uniprot id: A0A8M3B621
uniprot id: A0A8M3B624
uniprot id: A0A8M3B629
uniprot id: A0A8M6Z4D8
uniprot id: A0A8M9PEY4
uniprot id: A0A8M9PKM3
uniprot id: E9QDE5
uniprot id: F1QBV5
uniprot id: F1QJ64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

7955:tubgcp3
gene id: 7955:tubgcp3
uniprot id: A0A8M1N203
uniprot id: A0A8M2BI75
uniprot id: B8A509
uniprot id: F1QA15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

7955:arl4ca
gene id: 7955:arl4ca
uniprot id: Q561U6
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7955:atrx
gene id: 7955:atrx
uniprot id: A0A8M1PD71
uniprot id: A0A8M9QKH6
uniprot id: E7F4M2
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

7955:si:ch73-45o6.2
gene id: 7955:si:ch73-45o6.2
uniprot id: A0A0R4IKT5
uniprot id: A0A8M3AZN3
uniprot id: A0A8M3BEZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

7955:gstk2
gene id: 7955:gstk2
uniprot id: A0A8M6YVE9
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

7955:dusp6
gene id: 7955:dusp6
uniprot id: Q7T2L8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

7955:upf3a
gene id: 7955:upf3a
uniprot id: A0A8M2BFY4
uniprot id: B0S733
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RENT3 family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Cytoplasm
messages: Expressed during early cleavage, gastrulation and at 1 day post-fertilization.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. Binds spliced mRNA upstream of exon-exon junctions (By similarity).
messages: Morpholino knockdown results in a weakly abnormal brain patterning during development that does not affect embryo viability at 5 days post-fertilization.
messages: Nucleus

7955:ppp4r2b
gene id: 7955:ppp4r2b
uniprot id: A1L1M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP4R2 family.
messages: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

7955:brd1b
gene id: 7955:brd1b
uniprot id: A0A8M2BA66
names: Subcellular Location Annotation
messages: Nucleus

7955:kcnh1b
gene id: 7955:kcnh1b
uniprot id: A0A8M3AXZ2
uniprot id: K4EHU2
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch1073-153i20.5
gene id: 7955:si:ch1073-153i20.5
uniprot id: A0A140LGS2
uniprot id: A0A8M3ATV1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:xdh
gene id: 7955:xdh
uniprot id: A0A8N7UV58
uniprot id: E7F022
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Peroxisome

7955:phka1b
gene id: 7955:phka1b
uniprot id: A0A286YBM7
uniprot id: A0A8M3AME4
uniprot id: A0A8M9PJ81
uniprot id: A0A8M9PRF2
uniprot id: A0A8M9PUY3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

7955:baiap2b
gene id: 7955:baiap2b
uniprot id: A0A8M1RME1
uniprot id: A0A8M2B2R3
uniprot id: A0A8M3AYK1
uniprot id: A0A8M3AYL9
uniprot id: A0A8M3AYM2
uniprot id: A0A8M3B4T7
uniprot id: A0A8M3B7M0
uniprot id: A0A8M3BEB0
uniprot id: A0A8M9PX88
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

7955:hoxb9a
gene id: 7955:hoxb9a
uniprot id: Q9PWM2
names: Developmental Stage
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression limit at somite 7. At the 20-somite stage, expressed in the developing CNS with an anterior expression limit adjacent to the somite 3/somite 4 boundary.
messages: Belongs to the Abd-B homeobox family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:reep2
gene id: 7955:reep2
uniprot id: A0A8M2BKF7
uniprot id: Q4KMI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DP1 family.
messages: Interacts with odorant receptor proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May enhance the cell surface expression of odorant receptors.
messages: Membrane

7955:cltb
gene id: 7955:cltb
uniprot id: A0A286Y9F1
uniprot id: A0A8M2BFK7
uniprot id: A0A8M2BG62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

7955:zgc:63587
gene id: 7955:zgc:63587
uniprot id: A0A8M2BJN0
uniprot id: Q7SY26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium membrane
messages: spindle

7955:alad
gene id: 7955:alad
uniprot id: Q568L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

7955:eri2
gene id: 7955:eri2
uniprot id: Q502M8
names: Cofactor
names: Similarity
messages: Belongs to the ERI2 family.
messages: Binds 2 magnesium ions per subunit.

7955:api5
gene id: 7955:api5
uniprot id: A0A8M1PE19
uniprot id: A0A8M6Z4Y3
uniprot id: R4GDP5
names: Similarity
messages: Belongs to the API5 family.

7955:ttll6
gene id: 7955:ttll6
uniprot id: A8CVX7
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Cytoplasm
messages: Fish display a lack of tubulin polyglutamylation and cilia formation in olfactory placodes.
messages: Gln-174 is the main determinant for regioselectivity, which segregates between initiases and elongases in all tubulin--tyrosine ligase family. A glutamine residue at this position is found in elongases TTLL6, TTLL9, TTLL11, TTLL13, TTLL10 and favors glutamate-chain elongation, whereas an arginine residue is found in initiases TTLL2, TTLL4, TTLL5, TTLL3, TTLL8 and favors initiation.
messages: Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins (By similarity). Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction (By similarity). Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Mediates microtubule polyglutamylation in cilia axoneme, which is important for ciliary structural formation and motility (PubMed:17761526, PubMed:22246503). Polyglutamylates olfactory cilia, necessary for the regulation of ciliary sructure and beating (PubMed:17761526).
messages: The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding.
messages: cilium axoneme
messages: cilium basal body
messages: cytoskeleton

7955:rpl30
gene id: 7955:rpl30
uniprot id: Q7ZUG6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

7955:hsd17b2
gene id: 7955:hsd17b2
uniprot id: A0A8M2BAC5
uniprot id: Q1PLL0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:stmn2a
gene id: 7955:stmn2a
uniprot id: A0A8M1N2J6
uniprot id: E7FE68
names: Similarity
messages: Belongs to the stathmin family.

7955:mrpl2
gene id: 7955:mrpl2
uniprot id: A0A8M1P304
uniprot id: E7F8R3
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

7955:zgc:153441
gene id: 7955:zgc:153441
uniprot id: A0A8M3AKH3
uniprot id: A0A8M3B3T1
uniprot id: Q0P435
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:rsg1
gene id: 7955:rsg1
uniprot id: A0A8M3BAH8
uniprot id: Q66JN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

7955:agbl2
gene id: 7955:agbl2
uniprot id: A0A0R4IYD6
uniprot id: A0A8M1P7K9
uniprot id: A0A8M6Z500
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

7955:mon2
gene id: 7955:mon2
uniprot id: A0A8M9P6K6
uniprot id: A0A8M9PMY5
uniprot id: A0A8M9PV63
uniprot id: A0A8M9PYL9
names: Similarity
messages: Belongs to the MON2 family.

7955:tacr2
gene id: 7955:tacr2
uniprot id: F1QPL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:LOC103910991
gene id: 7955:LOC103910991
uniprot id: A0A0G2KEG5
uniprot id: A0A8M3AZ38
uniprot id: A0A8M9PHX4
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:rom1b
gene id: 7955:rom1b
uniprot id: Q7ZWC5
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

7955:LOC100535208
gene id: 7955:LOC100535208
uniprot id: A0A8M1RLY1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:tdrd3
gene id: 7955:tdrd3
uniprot id: A0A2R8RPE6
uniprot id: A0A8M1MZN5
uniprot id: A0A8M2BGQ3
uniprot id: A0A8M2BGT2
uniprot id: A0A8M9Q735
uniprot id: X1WG14
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

7955:vwc2
gene id: 7955:vwc2
uniprot id: B0I1T8
names: Subcellular Location Annotation
messages: Synapse

7955:s100a10b
gene id: 7955:s100a10b
uniprot id: Q7ZVA4
names: Similarity
messages: Belongs to the S-100 family.

7955:ube2f
gene id: 7955:ube2f
uniprot id: Q6NY82
names: Function
names: Similarity
names: Subunit
messages: Accepts the ubiquitin-like protein NEDD8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx2, but not rbx1, suggests that the rbx2-ube2f complex neddylates specific target proteins, such as cul5.
messages: Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
messages: Interacts with uba3 and rbx2.

7955:LOC101886356
gene id: 7955:LOC101886356
uniprot id: A0A8M6Z3B8
names: Subcellular Location Annotation
messages: Nucleus

7955:lamtor2
gene id: 7955:lamtor2
uniprot id: A0A8M1N1H4
uniprot id: F1R3H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

7955:stx5a
gene id: 7955:stx5a
uniprot id: Q6DG84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

7955:pparab
gene id: 7955:pparab
uniprot id: A6XMH7
uniprot id: K7DY57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

7955:zgc:113201
gene id: 7955:zgc:113201
uniprot id: Q501T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

7955:med10
gene id: 7955:med10
uniprot id: Q0VIA1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Negatively regulates the Wnt signaling pathway and positively regulates the Nodal signaling pathway. Required for cardiac cushion formation.
messages: Component of the Mediator complex.
messages: Expressed throughout embryogenesis.
messages: Nucleus

7955:fam83d
gene id: 7955:fam83d
uniprot id: A4QP72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM83 family.
messages: Cytoplasm
messages: May regulate cell proliferation, growth, migration and epithelial to mesenchymal transition. May also be important for proper chromosome congression and alignment during mitosis.
messages: spindle
messages: spindle pole

7955:hoxb5b
gene id: 7955:hoxb5b
uniprot id: A0A0R4I9D0
uniprot id: P09013
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At the 10-somite stage, barely detectable in the paraxial mesoderm. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit at somite 1.
messages: Belongs to the Antp homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:psmf1
gene id: 7955:psmf1
uniprot id: A0A0R4II16
uniprot id: A0A8M1N0P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

7955:traf2b
gene id: 7955:traf2b
uniprot id: A0A0R4ILY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

7955:mb21d1
gene id: 7955:mb21d1
uniprot id: A0A8N7UUZ3
uniprot id: F1QCP4
names: Similarity
messages: Belongs to the mab-21 family.

7955:timp4.3
gene id: 7955:timp4.3
uniprot id: A0A0R4IT47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

7955:camk2g2
gene id: 7955:camk2g2
uniprot id: A0A8M2B2Z3
uniprot id: A0A8M2B329
uniprot id: A0A8M2B390
uniprot id: A0A8M2B3P7
uniprot id: A0A8M2B3Q3
uniprot id: A0A8M2B3U7
uniprot id: A0A8M3AZ56
uniprot id: A0A8M3AZ91
uniprot id: A0A8M3B830
uniprot id: A0A8M3BEQ1
uniprot id: A0A8M3BEQ5
uniprot id: A0A8M9PU56
uniprot id: A0A8M9PU60
uniprot id: A0A8M9PYJ1
uniprot id: A0A8M9PYK5
uniprot id: A0A8M9PYL0
uniprot id: A0A8M9Q194
uniprot id: A0A8M9Q199
uniprot id: A0A8M9Q1A2
uniprot id: A0A8M9QA96
uniprot id: A0A8M9QAA1
uniprot id: A0A8M9QAA5
uniprot id: A0A8M9QFW0
uniprot id: A0A8M9QFW3
uniprot id: A0A8M9QFW7
uniprot id: A0A8M9QFX6
uniprot id: A0A8M9QFY3
uniprot id: A0A8M9QFY6
uniprot id: A0A8M9QK51
uniprot id: A0A8M9QK53
uniprot id: A0A8M9QK60
uniprot id: A0A8M9QK64
uniprot id: A0A8M9QK67
uniprot id: A0A8M9QK73
uniprot id: A0A8M9QK76
uniprot id: A0A8M9QNR1
uniprot id: A0A8M9QNR4
uniprot id: A0A8M9QNR7
uniprot id: A0A8M9QNS6
uniprot id: F1QW17
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

7955:LOC101882637
gene id: 7955:LOC101882637
uniprot id: A0A8M9PV20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:eve1
gene id: 7955:eve1
uniprot id: A0A8M2BIY4
uniprot id: F1R6B2
uniprot id: Q90265
names: Subcellular Location Annotation
messages: Nucleus

7955:moxd1
gene id: 7955:moxd1
uniprot id: Q5TZ24
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Endoplasmic reticulum membrane

7955:si:ch73-15n15.3
gene id: 7955:si:ch73-15n15.3
uniprot id: A0A8M9PNQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:dtnba
gene id: 7955:dtnba
uniprot id: A0A0R4IAV8
uniprot id: A0A0R4IMY9
uniprot id: A0A8M1P8H3
uniprot id: A0A8M1PA19
uniprot id: A0A8M2BFU1
uniprot id: A0A8M2BFW1
uniprot id: A0A8M2BGH1
uniprot id: F1RBV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

7955:vwf
gene id: 7955:vwf
uniprot id: A0A8N7XJA5
uniprot id: E7F9Z1
names: Subcellular Location Annotation
names: Subunit
messages: Multimeric. Interacts with F8.
messages: extracellular matrix

7955:apip
gene id: 7955:apip
uniprot id: A0A8M2BDX7
uniprot id: B2GRE0
uniprot id: Q66I75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.
messages: Cytoplasm

7955:best4
gene id: 7955:best4
uniprot id: A0A8N7UT59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

7955:dnal1
gene id: 7955:dnal1
uniprot id: Q6DHB1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein light chain LC1-type family.
messages: Interacts with DNAH5, a outer arm dynein heavy chain. Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner.
messages: Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.
messages: Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity).
messages: cilium axoneme

7955:or104-2
gene id: 7955:or104-2
uniprot id: Q2PRL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:ppm1k
gene id: 7955:ppm1k
uniprot id: A0A8M1P874
uniprot id: F1R0V7
names: Similarity
messages: Belongs to the PP2C family.

7955:si:ch211-150g13.3
gene id: 7955:si:ch211-150g13.3
uniprot id: A0A8N7UV38
uniprot id: E7F7K7
names: Similarity
messages: Belongs to the TMEM178 family.

7955:hadhb
gene id: 7955:hadhb
uniprot id: Q7ZTH6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

7955:or112-1
gene id: 7955:or112-1
uniprot id: A0A8M1RJ33
uniprot id: F1QQU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:ggcx
gene id: 7955:ggcx
uniprot id: A0A8M1RIV5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
messages: Membrane

7955:scn3b
gene id: 7955:scn3b
uniprot id: A0A8M3APT8
uniprot id: A0A8M3ASQ5
uniprot id: F8W4B3
uniprot id: Q06W27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

7955:kdm4ab
gene id: 7955:kdm4ab
uniprot id: A0A8M1PZC5
uniprot id: F1QNG0
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

7955:htr7a
gene id: 7955:htr7a
uniprot id: A0A8M9PVG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:zgc:172315
gene id: 7955:zgc:172315
uniprot id: A8WGC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:nln
gene id: 7955:nln
uniprot id: A0A2R8RVE2
uniprot id: A0A8M2B1N0
uniprot id: A0A8M2B1S5
uniprot id: A0A8M6Z2X4
uniprot id: Q5XIZ1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

7955:zranb2
gene id: 7955:zranb2
uniprot id: A0A8M1P4J9
uniprot id: A0A8M6Z7B1
uniprot id: E7F1Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: May interfere with constitutive 5'-splice site selection.
messages: Nucleus

7955:zgc:152863
gene id: 7955:zgc:152863
uniprot id: A0A0R4IPP5
uniprot id: A0A8M3APT4
uniprot id: A0JMC6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:cpt2
gene id: 7955:cpt2
uniprot id: B2GQ15
uniprot id: Q5U3U3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: Mitochondrion inner membrane

7955:alp3
gene id: 7955:alp3
uniprot id: A0A8N7XJG1
uniprot id: H9GX67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

7955:olfch1
gene id: 7955:olfch1
uniprot id: A0A0R4IC00
uniprot id: A0A8M1NGH5
uniprot id: A0A8M3AKH1
uniprot id: A0A8M3AS15
uniprot id: A0A8M3AUY6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:kcna1a
gene id: 7955:kcna1a
uniprot id: E7FFE9
names: Subcellular Location Annotation
messages: Membrane

7955:ptger1b
gene id: 7955:ptger1b
uniprot id: D0EXE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:si:dkey-246g23.2
gene id: 7955:si:dkey-246g23.2
uniprot id: A0A8M6YTN0
uniprot id: A0A8M9PAC3
uniprot id: A3KQM5
names: Subcellular Location Annotation
messages: Membrane

7955:mpp7b
gene id: 7955:mpp7b
uniprot id: A0A8M9PBT4
names: Similarity
messages: Belongs to the MAGUK family.

7955:zfx
gene id: 7955:zfx
uniprot id: E7F557
names: Subcellular Location Annotation
messages: Nucleus

7955:slc6a16b
gene id: 7955:slc6a16b
uniprot id: A0A8M6Z4Q3
uniprot id: A4QP62
uniprot id: F1Q9B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:slc16a1a
gene id: 7955:slc16a1a
uniprot id: E7F7B3
uniprot id: H1ABV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

7955:tmem185
gene id: 7955:tmem185
uniprot id: Q7SYC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM185 family.
messages: Membrane

7955:si:ch211-184m13.4
gene id: 7955:si:ch211-184m13.4
uniprot id: B3DK24
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:entpd3
gene id: 7955:entpd3
uniprot id: A0A8M2B467
uniprot id: A4IG37
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

7955:auh
gene id: 7955:auh
uniprot id: A0A8M1N1I7
uniprot id: F1RDX1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

7955:parietopsin
gene id: 7955:parietopsin
uniprot id: A0A0N9NY07
uniprot id: F1QYR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7955:si:ch211-210c8.6
gene id: 7955:si:ch211-210c8.6
uniprot id: A0A8M9PFL7
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100004033
gene id: 7955:LOC100004033
uniprot id: A0A8M6Z1W1
names: Subcellular Location Annotation
messages: Membrane

7955:nceh1a
gene id: 7955:nceh1a
uniprot id: Q6DKF1
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

7955:ppan
gene id: 7955:ppan
uniprot id: Q7ZVK7
names: Subcellular Location Annotation
messages: nucleolus

7955:cdk8
gene id: 7955:cdk8
uniprot id: A0A8M2B9W5
uniprot id: A8E4S2
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:zgc:174153
gene id: 7955:zgc:174153
uniprot id: A8KBT8
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:cyp8b2
gene id: 7955:cyp8b2
uniprot id: A8KBX6
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:tfb1m
gene id: 7955:tfb1m
uniprot id: A0A8M2BH57
uniprot id: A0A8M9P924
uniprot id: A0A8M9PEE3
uniprot id: A0A8M9PNX5
uniprot id: Q08C48
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:slc39a5
gene id: 7955:slc39a5
uniprot id: A0A8N7TDT7
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100330864
gene id: 7955:LOC100330864
uniprot id: A0A8M1P9Q8
uniprot id: G3G7U0
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

7955:mpp5b
gene id: 7955:mpp5b
uniprot id: A0A8M3AL41
uniprot id: A0A8M3B4D4
uniprot id: D3X469
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: tight junction

7955:vwa2
gene id: 7955:vwa2
uniprot id: U3JA51
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:prf1.2
gene id: 7955:prf1.2
uniprot id: A0A0R8WGG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

7955:cnpy2
gene id: 7955:cnpy2
uniprot id: Q0V965
names: Similarity
messages: Belongs to the canopy family.

7955:st14b
gene id: 7955:st14b
uniprot id: A0A8M3AWU9
uniprot id: A0JMD7
uniprot id: E9QD17
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:gas6
gene id: 7955:gas6
uniprot id: Q7T3H4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:hmga1a
gene id: 7955:hmga1a
uniprot id: E9QD31
uniprot id: Q6NV11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

7955:gabrg3
gene id: 7955:gabrg3
uniprot id: A0A8M3B3K2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:sema3c
gene id: 7955:sema3c
uniprot id: A0A8M6Z658
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:cel.2
gene id: 7955:cel.2
uniprot id: A0A8M9PQY7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

7955:prf1.9
gene id: 7955:prf1.9
uniprot id: E7F996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

7955:slc25a17
gene id: 7955:slc25a17
uniprot id: A0A8M1NDU0
uniprot id: A5D6T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:csnk1a1
gene id: 7955:csnk1a1
uniprot id: A0A2R8Q421
uniprot id: A0A8M3AHW8
uniprot id: A8KBX5
uniprot id: Q8JG73
uniprot id: Q8JGT0
uniprot id: Q8JHD9
uniprot id: Q8JHE0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:cldni
gene id: 7955:cldni
uniprot id: Q90XR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:hpf1
gene id: 7955:hpf1
uniprot id: Q7SXS8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HPF1 family.
messages: Chromosome
messages: Cofactor for serine ADP-ribosylation that confers serine specificity on parp1 and parp2 and plays a key role in DNA damage response. Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by parp1 and parp2 and switches the amino acid specificity of parp1 and parp2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins. Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Hpf1 acts by completing the active site of parp1 and parp2: forms a composite active site composed of residues from Hpf1 and parp1 or parp2. While hpf1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of parp1 and parp2 in order to limit the length of poly-ADP-ribose chains. Hpf1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on parp1.
messages: Expressed maternally: detected as early as 0 hour post-fertilization (hpf), before zygotic expression transcripts starts.
messages: In adult, mainly expressed in gonads.
messages: Interacts with PARP1 (via the PARP catalytic domain). Interacts with PARP2 (via the PARP catalytic domain). Interacts with core nucleosomes in a parp1- and parp2-dependent manner.
messages: Morpholino knockdown of the protein causes malformation anbd delayed hatching.
messages: Nucleus

7955:zgc:101731
gene id: 7955:zgc:101731
uniprot id: A0A8M2B406
uniprot id: Q4V9B6
uniprot id: Q66ID7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

7955:sema4d
gene id: 7955:sema4d
uniprot id: A0A8M9PCY2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ptpn2a
gene id: 7955:ptpn2a
uniprot id: A0A8M1PCX4
uniprot id: F1Q8I4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

7955:ddr2l
gene id: 7955:ddr2l
uniprot id: A0A0R4IYW2
uniprot id: A0A8N7T7R5
names: Subcellular Location Annotation
messages: Membrane

7955:hspb9
gene id: 7955:hspb9
uniprot id: A5JV82
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7955:actn3b
gene id: 7955:actn3b
uniprot id: Q8AX99
names: Similarity
messages: Belongs to the alpha-actinin family.

7955:ap2s1
gene id: 7955:ap2s1
uniprot id: Q6PEJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

7955:fabp10a
gene id: 7955:fabp10a
uniprot id: B2GQZ3
uniprot id: Q9I8L5
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A member of the basic liver-type FABPs, which are only found, thus far, in non-mammalian vertebrates.
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds hydrophobic ligands, such as cholate, in the cytoplasm. May be involved in intracellular lipid transport (By similarity). Binds one cholate per subunit.
messages: Cytoplasm
messages: Expressed in the developing embryonic liver from 48 hpf. Also expressed in the liver of 5-day-old larvae. In adults, primarily expressed in the liver, with weak expression in the testis and intestine.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: PubMed:12633865 reports expression in the ventral endoderm at 36 hpf, whereas PubMed:16857010 does not detect expression this early. The different timings may reflect strain-specific differences.

7955:hs6st1b
gene id: 7955:hs6st1b
uniprot id: A0MGZ5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: During early somitogenesis, first expressed in floor plate and somites. During mid-somitogenesis, expressed strongly in somites and more weakly in eye and hindbrain. During late somitogenesis, expressed in eye, hindbrain and posterior somites. At 24 hours post-fertilization (hpf), expressed in lens, forebrain, hindbrain, otic vesicle, anterior spinal cord neurons and posterior somites. At 36 hpf, expressed in the retinal ciliary marginal zone, brain, pancreas and weakly in pectoral fin. At 48 hpf, expressed in the retinal ciliary marginal zone, retinal ganglion cells, rhombomeres, otic vesicle and weakly in pectoral fin.
messages: Expressed both maternally and zygotically. Expression is lost before gastrulation and begins again during early somitogenesis.
messages: Membrane

7955:hspb1
gene id: 7955:hspb1
uniprot id: A4VAK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: spindle

7955:si:ch1073-165f9.2
gene id: 7955:si:ch1073-165f9.2
uniprot id: A0A8M1RM53
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7955:foxo3b
gene id: 7955:foxo3b
uniprot id: Q9W7F8
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC101884805
gene id: 7955:LOC101884805
uniprot id: P0DM64
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activator of melanocortin receptor 4 (mc4r), a receptor involved in energy homeostasis. Plays a role after larval development in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of mc4r and mc4r-mediated generation of cAMP once the zebrafish begins feeding, increasing the capacity for regulated feeding and growth.
messages: Belongs to the MRAP family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Expressed in adult brain.
messages: Interacts with mc4r.
messages: Not expressed in embryos. Mainly expressed in adult.
messages: Two paralogs of MRAP2 are present in zebrafish: mrap2a, which plays a role during larval development and mrap2b, which constitutes the ortholog of mammalian MRAP2.

7955:pappab
gene id: 7955:pappab
uniprot id: A0A8M3ASU7
uniprot id: M1WXG8
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:yy1a
gene id: 7955:yy1a
uniprot id: Q6IQQ3
uniprot id: Q7T1S3
names: Similarity
messages: Belongs to the YY transcription factor family.

7955:snap25a
gene id: 7955:snap25a
uniprot id: Q5TZ66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Expressed in several regions throughout the adult brain, including the mesencephalon.
messages: May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
messages: synaptosome

7955:crygm2e
gene id: 7955:crygm2e
uniprot id: A0A8N7TEM3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:si:ch211-246m6.5
gene id: 7955:si:ch211-246m6.5
uniprot id: A0A8M3B5G3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rh50
gene id: 7955:rh50
uniprot id: A0A8N7UYZ2
uniprot id: B0UYU0
uniprot id: Q9IAC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Cell membrane
messages: Functions as an ammonia transporter. May play a role in the elimination of ammonia in the gill.
messages: Membrane

7955:kif23
gene id: 7955:kif23
uniprot id: A0A286Y967
uniprot id: A0A8M3AUT8
uniprot id: A0A8M9P0Y6
uniprot id: A0A8M9PLX5
uniprot id: Q9PUU5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:mettl10
gene id: 7955:mettl10
uniprot id: Q5D013
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

7955:uhrf1
gene id: 7955:uhrf1
uniprot id: E7EZF3
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Embryos have a small head, eyes, jaw and an underdeveloped gut. Moreover many mutants display diminished yolk consumption and uninflated swim bladder as well as embryonic lethality. DNA methylation is impaired during embryogenesis and embryos display defects in lens development and maintenance. No fertility defects are noted for heterozygous animals.
messages: Expressed in proliferating tissues. Highly expressed 24-48 hours after fertilization (hpf) in rapidly proliferating tissues, including the tectum, retina and brachial arches. Preferentially expressed in the liver bud and expression is maintained in the fully developed liver. Also expressed in the proximal gut. In adult, the highest expression is detected in testis.
messages: Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins. However, it is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo (By similarity). Required for pregastrula and lens development.
messages: Nucleus
messages: Phosphorylation at Ser-649 is required for gastrulation.
messages: The RING finger is required for ubiquitin ligase activity.
messages: The YDG domain (also named SRA domain) specifically recognizes and binds hemimethylated DNA at replication forks (DNA that is only methylated on the mother strand of replicating DNA).
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

7955:si:ch73-56d11.3
gene id: 7955:si:ch73-56d11.3
uniprot id: E9QHI6
names: Similarity
messages: Belongs to the MS4A family.

7955:mtmr10
gene id: 7955:mtmr10
uniprot id: A0A8M2BG48
uniprot id: A0A8N1YZF7
uniprot id: E7F1F0
uniprot id: F1Q8B7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7955:capn5b
gene id: 7955:capn5b
uniprot id: A0A8M1Q2A3
uniprot id: A0A8M3ATX3
uniprot id: E7F7F1
names: Similarity
messages: Belongs to the peptidase C2 family.

7955:fzd5
gene id: 7955:fzd5
uniprot id: B3DIG4
uniprot id: B3DIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

7955:galnt14
gene id: 7955:galnt14
uniprot id: A0A8M1N9Y0
uniprot id: A0A8M6Z2P3
uniprot id: A0A8M9PHF5
uniprot id: Q5RFV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:ube2e3
gene id: 7955:ube2e3
uniprot id: B0S6A7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:mafb
gene id: 7955:mafb
uniprot id: Q98UK4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional activator or repressor.
messages: Belongs to the bZIP family. Maf subfamily.
messages: Expressed in the lens fiber cells during embryogenesis. During somitogenesis expressed in somitic cells (at protein level).
messages: Homodimer or heterodimer. Binds DNA as a homodimer or a heterodimer (By similarity).
messages: Nucleus

7955:mrpl3
gene id: 7955:mrpl3
uniprot id: A0A0R4IY00
uniprot id: A0A8M2B6E9
uniprot id: Q7SXD6
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

7955:dlx4b
gene id: 7955:dlx4b
uniprot id: Q98878
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: During larvae development, may be important for neurocranium morphogenesis.
messages: Morpholino knockdown of the protein causes reduced cranial outgrowth and defects of the cartilaginous elements of the jaw.
messages: Nucleus

7955:zgc:65851
gene id: 7955:zgc:65851
uniprot id: Q6NZX1
uniprot id: Q7SZP4
names: Similarity
messages: Belongs to the intermediate filament family.

7955:kmt2cb
gene id: 7955:kmt2cb
uniprot id: A0A8M2BAF3
uniprot id: A0A8M2BAH2
uniprot id: A0A8M3AP79
uniprot id: A0A8M3APU4
uniprot id: A0A8M3AWQ1
uniprot id: A0A8M3B7B2
uniprot id: A0A8M6YVA2
uniprot id: A0A8M6Z161
uniprot id: A0A8M6Z169
names: Subcellular Location Annotation
messages: Nucleus

7955:si:dkey-11f12.2
gene id: 7955:si:dkey-11f12.2
uniprot id: A0A8M1P951
uniprot id: E7F782
names: Similarity
messages: Belongs to the mab-21 family.

7955:plpp7
gene id: 7955:plpp7
uniprot id: Q6P0E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus envelope
messages: Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).

7955:si:dkeyp-118h3.6
gene id: 7955:si:dkeyp-118h3.6
uniprot id: Q32LR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

7955:rad52
gene id: 7955:rad52
uniprot id: A0A8M2BA53
uniprot id: F1QXE3
uniprot id: Q4U0V2
names: Similarity
messages: Belongs to the RAD52 family.

7955:pargl
gene id: 7955:pargl
uniprot id: A0A0R4ITH7
uniprot id: A0A8M1Q1P0
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

7955:abcg5
gene id: 7955:abcg5
uniprot id: B3DG12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7955:syt14b
gene id: 7955:syt14b
uniprot id: A0A286Y918
uniprot id: A0A8M1P365
uniprot id: A0A8M3AT24
uniprot id: A0A8M9PBT7
names: Similarity
messages: Belongs to the synaptotagmin family.

7955:tnfsf10l4
gene id: 7955:tnfsf10l4
uniprot id: Q0PKX8
uniprot id: Q5EAP6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:mat2al
gene id: 7955:mat2al
uniprot id: Q1RLT0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

7955:tecra
gene id: 7955:tecra
uniprot id: A0A286YB23
uniprot id: A0A8M1QQW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:idh1
gene id: 7955:idh1
uniprot id: A0A8M2BF40
uniprot id: Q802Y2
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

7955:zswim7
gene id: 7955:zswim7
uniprot id: A4FVI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWS1 family.
messages: Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

7955:wdr78
gene id: 7955:wdr78
uniprot id: F1QHZ6
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Dynein axonemal particle
messages: Morpholino knockdown results in ciliopathy-related phenotypes, such as curved bodies, hydrocephalus, abnormal otolith, randomized left-right asymmetry, and pronephric cysts, accompanied with paralyzed pronephric cilia.
messages: Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains.
messages: Plays a critical role in the assembly of axonemal dynein complex (By similarity). Plays a key role in ciliary motility (PubMed:30060180).
messages: cilium axoneme
messages: flagellum axoneme

7955:impdh1a
gene id: 7955:impdh1a
uniprot id: A0A8M2B5K3
uniprot id: A0A8M2B5Y5
uniprot id: A0A8M3ART7
uniprot id: B2GRR5
uniprot id: Q6GMG5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

7955:adgrl3.1
gene id: 7955:adgrl3.1
uniprot id: A0A2R8Q6E9
uniprot id: A0A2R8QM07
uniprot id: A0A8M2BI50
uniprot id: A0A8M2BI94
uniprot id: A0A8M2BIN7
uniprot id: A0A8M9Q934
uniprot id: A0A8N7UUV2
uniprot id: F1Q579
names: Subcellular Location Annotation
messages: Membrane

7955:kcnab1b
gene id: 7955:kcnab1b
uniprot id: A0A8M3AQ10
uniprot id: A0A8M9PRF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

7955:kcnj1a.3
gene id: 7955:kcnj1a.3
uniprot id: Q1LUX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:fam46ba
gene id: 7955:fam46ba
uniprot id: A0JPF6
names: Similarity
messages: Belongs to the TENT family.

7955:zgc:77929
gene id: 7955:zgc:77929
uniprot id: A0A8M2B2P1
uniprot id: Q6NZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: Secreted

7955:comta
gene id: 7955:comta
uniprot id: F4ZGF2
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Shows highest activity towards catecholestrogens and dobutamine. Also has lower activity towards L-DOPA, dopamine and epinephrine. Active towards the xenobiotic compounds methyl-DOPA, carbidopa, isoproterenol, and apomorphine.
messages: Highly expressed in unfertilized eggs. Has low expression during embryogenesis. Expression then increases after hatching (48 hours post-fertilization), reaching maximum levels at 3 weeks of age.
messages: Secreted
messages: Widely expressed (PubMed:28844929). Has higher expression in females compared to males (PubMed:21371608). Strongly expressed in liver and diencephalon (PubMed:28844929). Expressed at lower levels in hindbrain, spinal cord, eye, telencephalon, spleen, gut, gill and muscle (PubMed:28844929). Detected in ovary and testis (PubMed:28844929). In eye, detected in all layers of the retina with highest expression in the inner nuclear layer (PubMed:28844929). In gut, expressed in the lamina propria but has little or no expression in gut epithelium (PubMed:28844929). In brain, has strongest expression near the midline of the telencephalon, in the periventricular gray zone of the optic tectum, in the preglomerular nucleus, and near the walls of the diencephalic ventricle (PubMed:28844929).

7955:stk17a
gene id: 7955:stk17a
uniprot id: A4IFW6
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:trub2
gene id: 7955:trub2
uniprot id: A0A8M1N020
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

7955:mapk8a
gene id: 7955:mapk8a
uniprot id: A0A8M6Z2A6
uniprot id: A0A8M6Z3T6
uniprot id: A8WG58
uniprot id: E9QBW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

7955:cep170aa
gene id: 7955:cep170aa
uniprot id: A0A8M3AYX2
uniprot id: A0A8M3AYY4
uniprot id: A0A8M3AYY9
uniprot id: A0A8M3B539
uniprot id: A0A8M9PYF0
uniprot id: A0A8M9QK29
uniprot id: A0A8M9QNN4
uniprot id: A0A8N7T6W1
uniprot id: F1QAR8
names: Similarity
messages: Belongs to the CEP170 family.

7955:n4bp1
gene id: 7955:n4bp1
uniprot id: Q1LVK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP1 family.
messages: It is uncertain whether Met-1 or Met-10 is the initiator.
messages: Nucleus
messages: PML body
messages: Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults (By similarity). Has ribonuclease activity (By similarity).
messages: nucleolus

7955:foxe3
gene id: 7955:foxe3
uniprot id: B0UXI3
uniprot id: B3DJ39
names: Subcellular Location Annotation
messages: Nucleus

7955:si:ch73-209e20.5
gene id: 7955:si:ch73-209e20.5
uniprot id: A0A8M9PQU8
uniprot id: E7FBL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

7955:nprl2
gene id: 7955:nprl2
uniprot id: Q0P403
names: Similarity
messages: Belongs to the NPR2 family.

7955:meis1a
gene id: 7955:meis1a
uniprot id: A0A8M2B7B4
uniprot id: Q7SZP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

7955:tie1
gene id: 7955:tie1
uniprot id: A0A2R8QM04
uniprot id: A0A8M1P5F4
uniprot id: A0A8M1Q1D2
uniprot id: G1K2H0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:kcnab1a
gene id: 7955:kcnab1a
uniprot id: A0A8M9P126
uniprot id: A0A8M9PA23
uniprot id: A0A8M9PFF1
uniprot id: A0A8M9PM35
uniprot id: A0A8M9PQ73
uniprot id: Q58EC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

7955:LOC110437888
gene id: 7955:LOC110437888
uniprot id: A0A8M9NYG8
uniprot id: A0A8M9PIE6
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

7955:artn
gene id: 7955:artn
uniprot id: A0A8M2BHZ9
uniprot id: A0A8M9Q024
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

7955:selt2
gene id: 7955:selt2
uniprot id: Q502K9
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the SelWTH family. Selenoprotein T subfamily.
messages: May contain a selenide-sulfide bond between Cys-62 and Sec-65. This bond is speculated to serve as redox-active pair (By similarity).
messages: Widely expressed in the embryo.

7955:zgc:110366
gene id: 7955:zgc:110366
uniprot id: A0A8M1N5M6
uniprot id: A0A8M1P5H7
uniprot id: A0A8M2BAE4
uniprot id: A8DZH9
uniprot id: U3JA33
names: Similarity
messages: Belongs to the aldo/keto reductase family.

7955:clns1a
gene id: 7955:clns1a
uniprot id: Q7ZTV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

7955:uox
gene id: 7955:uox
uniprot id: Q6DG85
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Competitively inhibited by xanthine.
messages: Homotetramer; dimer of dimers.
messages: Peroxisome

7955:gpx3
gene id: 7955:gpx3
uniprot id: A0A8M1NIR5
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7955:mhc1ula
gene id: 7955:mhc1ula
uniprot id: A0A0S1RUH3
uniprot id: A0A8M9PVE6
names: Similarity
messages: Belongs to the MHC class I family.

7955:lhx2b
gene id: 7955:lhx2b
uniprot id: A0A8M1N8T6
uniprot id: A0A8M2BEV2
uniprot id: A0A8M2BFE8
uniprot id: B0R107
names: Subcellular Location Annotation
messages: Nucleus

7955:ubtd1b
gene id: 7955:ubtd1b
uniprot id: Q4V8W7
names: Function
messages: May be involved in the regulation of cellular senescence through a positive feedback loop with TP53.

7955:supt3h
gene id: 7955:supt3h
uniprot id: A0A8M9P8V4
uniprot id: Q6DHL1
names: Subcellular Location Annotation
messages: Nucleus

7955:eaf1
gene id: 7955:eaf1
uniprot id: Q6IQD2
names: Similarity
messages: Belongs to the EAF family.

7955:itpkca
gene id: 7955:itpkca
uniprot id: A0A8N7T5H5
uniprot id: E7F4R8
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:clk4a
gene id: 7955:clk4a
uniprot id: A0A8M1RNS5
uniprot id: E7F7P1
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:figf
gene id: 7955:figf
uniprot id: A0A8M3AXQ4
uniprot id: Q208T6
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:tekt1
gene id: 7955:tekt1
uniprot id: A0A0R4IRF0
uniprot id: A0A8M3ASX1
uniprot id: Q5U3Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

7955:LOC101886665
gene id: 7955:LOC101886665
uniprot id: A0A8M9PPK8
names: Similarity
messages: Belongs to the TGF-beta family.

7955:c1qc
gene id: 7955:c1qc
uniprot id: Q5XJ71
names: Function
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

7955:si:dkey-242e21.4
gene id: 7955:si:dkey-242e21.4
uniprot id: P0DOC8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis (By similarity).
messages: Photoreceptor inner segment
messages: Results in the cardinal features of Bardet-Biedl syndrome, including defects to the ciliated Kupffer's vesicle, delayed retrograde melanosome transport and impaired visual behavior.
messages: Ubiquitously expressed during early development and in adult tissues including the eye, brain, heart and kidney (PubMed:27008867).

7955:cul1b
gene id: 7955:cul1b
uniprot id: A0A8M9PTY1
uniprot id: Q802D4
names: Similarity
messages: Belongs to the cullin family.

7955:LOC101883537
gene id: 7955:LOC101883537
uniprot id: A0A8M2BCY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:tmcc1b
gene id: 7955:tmcc1b
uniprot id: A0A8M6Z126
uniprot id: Q08BC7
names: Similarity
messages: Belongs to the TEX28 family.

7955:cplx4c
gene id: 7955:cplx4c
uniprot id: D2K293
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

7955:pomcb
gene id: 7955:pomcb
uniprot id: A0A8M1NCD8
uniprot id: Q5SPP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

7955:bckdha
gene id: 7955:bckdha
uniprot id: Q4VBU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

7955:rab9b
gene id: 7955:rab9b
uniprot id: A0A8M3BF01
uniprot id: E7F8G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: phagosome membrane

7955:chrna3
gene id: 7955:chrna3
uniprot id: A0A8M1QHJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:noc4l
gene id: 7955:noc4l
uniprot id: B2GT01
uniprot id: Q4VBT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane
messages: nucleolus

7955:LOC108191522
gene id: 7955:LOC108191522
uniprot id: A0A8M6Z8I9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:ugt5g2
gene id: 7955:ugt5g2
uniprot id: D3XDB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:pygmb
gene id: 7955:pygmb
uniprot id: E7EXT3
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

7955:phb
gene id: 7955:phb
uniprot id: A0A0B5JQ92
uniprot id: A0A8M2BB12
uniprot id: Q7T1D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

7955:myg1
gene id: 7955:myg1
uniprot id: A0A140LG01
uniprot id: A0A8M1P777
names: Similarity
messages: Belongs to the MYG1 family.

7955:eed
gene id: 7955:eed
uniprot id: A0A8M1N587
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

7955:cnn1a
gene id: 7955:cnn1a
uniprot id: A0A8M1NT80
uniprot id: B8A668
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

7955:tnfa
gene id: 7955:tnfa
uniprot id: Q08CQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Membrane

7955:nr1d1
gene id: 7955:nr1d1
uniprot id: A0A8N1TWU0
uniprot id: F1RAU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

7955:cnnm2a
gene id: 7955:cnnm2a
uniprot id: A0A8M1NR12
uniprot id: A2ATX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

7955:zgc:91976
gene id: 7955:zgc:91976
uniprot id: Q5U3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

7955:tmem163b
gene id: 7955:tmem163b
uniprot id: A0A0R4IQD0
uniprot id: A0A8M1RMP0
uniprot id: A0A8M2BLF0
uniprot id: F2Z4R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: May bind zinc and other divalent cations and recruit them to vesicular organelles.
messages: Membrane
messages: synaptic vesicle membrane

7955:mrpl57
gene id: 7955:mrpl57
uniprot id: Q6PBR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL63 family.
messages: Mitochondrion

7955:atp6v1ba
gene id: 7955:atp6v1ba
uniprot id: Q8QHA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

7955:zgc:110425
gene id: 7955:zgc:110425
uniprot id: Q503M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:anxa3a
gene id: 7955:anxa3a
uniprot id: Q66ID8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

7955:lgals3bpb
gene id: 7955:lgals3bpb
uniprot id: Q6NY73
names: Function
names: Subcellular Location Annotation
messages: Promotes integrin-mediated cell adhesion.
messages: Secreted
messages: extracellular matrix

7955:b3gnt5b
gene id: 7955:b3gnt5b
uniprot id: A0A8M1NDQ2
uniprot id: A5WVT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:caprin1b
gene id: 7955:caprin1b
uniprot id: A0A8M9P113
uniprot id: A0A8M9PM15
uniprot id: Q802U4
names: Similarity
messages: Belongs to the caprin family.

7955:mast2
gene id: 7955:mast2
uniprot id: A0A8M1PUY5
uniprot id: A0A8M2BDT3
uniprot id: A0A8M3ATG2
uniprot id: A0A8M3BAG4
uniprot id: A0A8M9PMZ8
uniprot id: E7F723
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

7955:olfcq19
gene id: 7955:olfcq19
uniprot id: A0A8M3AJP1
uniprot id: A0T301
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:zgc:92162
gene id: 7955:zgc:92162
uniprot id: Q6DHQ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

7955:atp6ap1a
gene id: 7955:atp6ap1a
uniprot id: A0A8M1Q7E2
uniprot id: F1R9A7
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

7955:lgalslb
gene id: 7955:lgalslb
uniprot id: A0A8M1N326
uniprot id: Q7ZZ26
names: Function
messages: Does not bind lactose, and may not bind carbohydrates.

7955:slc2a10
gene id: 7955:slc2a10
uniprot id: F1R0H0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Endomembrane system
messages: Expressed both maternally and zygotically (PubMed:21553381). Ubiquitous expression until the early somitogenesis stage (PubMed:21553381). In later embryonic stages, detected in the otic vesicles, hatching gland cells, pectoral fin, posterior tectum and swim bladder (PubMed:21553381).
messages: Facilitative glucose transporter required for the development of the cardiovascular system.
messages: Morpholino knockdown of the protein causes notochord and cardiovascular abnormalities (PubMed:22116938). Fishes display a reduced heart rate and blood flow, coupled with an incomplete and irregular vascular patterning (PubMed:22116938).
messages: perinuclear region

7955:zgc:171965
gene id: 7955:zgc:171965
uniprot id: A7E2M1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:crygs2
gene id: 7955:crygs2
uniprot id: B3DGE1
uniprot id: Q5XTP1
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:LOC565905
gene id: 7955:LOC565905
uniprot id: A0A8M6YZ49
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:nap1l1
gene id: 7955:nap1l1
uniprot id: A0A8M2BJ06
uniprot id: A0A8M2BJ13
uniprot id: A0A8M9PH16
uniprot id: B2GTB4
uniprot id: Q803X7
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7955:rhpn1
gene id: 7955:rhpn1
uniprot id: A0A8M1RP49
names: Similarity
messages: Belongs to the RHPN family.

7955:pigm
gene id: 7955:pigm
uniprot id: Q7T310
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity).

7955:slc5a7a
gene id: 7955:slc5a7a
uniprot id: A0A8M9QA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7955:aldh2.1
gene id: 7955:aldh2.1
uniprot id: Q7SXU3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

7955:armc1l
gene id: 7955:armc1l
uniprot id: A0A8M1P9L0
uniprot id: F1R385
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

7955:stxbp1b
gene id: 7955:stxbp1b
uniprot id: A2BGE0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

7955:si:dkey-172j4.3
gene id: 7955:si:dkey-172j4.3
uniprot id: A0A8M2BJQ6
uniprot id: A0A8M3BAY3
uniprot id: F1R561
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

7955:ap2m1b
gene id: 7955:ap2m1b
uniprot id: A0A8M3B366
uniprot id: F1RD00
uniprot id: Q7ZW98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids (By similarity).
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

7955:ncor1
gene id: 7955:ncor1
uniprot id: A0A8M2BCM0
uniprot id: A0A8M3ASH4
uniprot id: A0A8M3AZS6
uniprot id: A0A8M3B2M9
uniprot id: A0A8M3B9S7
uniprot id: A8B6H7
names: Similarity
messages: Belongs to the N-CoR nuclear receptor corepressors family.

7955:rbpms2a
gene id: 7955:rbpms2a
uniprot id: A0A8M9PGS4
uniprot id: A0A8M9PMP2
uniprot id: A0A8M9PUW5
uniprot id: A0A8M9PYB9
uniprot id: Q6DH13
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expressed exclusively in retinal ganglion cells during and after axogenesis.
messages: Interacts with Bucky ball (BUC); to mediate Balbiani body formation and oocyte polarity during early oogenesis.
messages: Knock-down leads to topographic missorting in the optic tract through the up-regulation of NRP1.
messages: RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (By similarity). RNA-binding protein localized in Balbiani body (electron-dense aggregates in the oocyte) and germ plasm during oogenesis, and may be required to maintain germ plasm mRNA translational repression (PubMed:18582455). Translational regulator during topographic map formation in the visual system (PubMed:27974617). Establishes oocyte polarity through interaction with Bucky ball (BUC) (Probable).

7955:eif2b4
gene id: 7955:eif2b4
uniprot id: A0A286Y8J6
uniprot id: A0A8M2B7A1
uniprot id: A0A8M2B7A3
uniprot id: A0A8M2B7A7
uniprot id: Q58EJ2
uniprot id: Q5RIE1
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

7955:st6gal2a
gene id: 7955:st6gal2a
uniprot id: F1Q8R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:atxn1l
gene id: 7955:atxn1l
uniprot id: A0A8M1Q1A0
uniprot id: E7FB74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

7955:zgc:112392
gene id: 7955:zgc:112392
uniprot id: Q501Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

7955:kcng4b
gene id: 7955:kcng4b
uniprot id: A0A8M3B1J1
uniprot id: E7F5Q8
names: Subcellular Location Annotation
messages: Membrane

7955:acap3b
gene id: 7955:acap3b
uniprot id: A0A8M6Z8L8
uniprot id: A0A8M9QCW6
uniprot id: A0A8M9QLG2
uniprot id: A2RUY3
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

7955:tas2r200.2
gene id: 7955:tas2r200.2
uniprot id: B3DIT2
uniprot id: Q58WW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

7955:fam162a
gene id: 7955:fam162a
uniprot id: A3KP48
uniprot id: F1QIC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

7955:si:ch73-70c5.1
gene id: 7955:si:ch73-70c5.1
uniprot id: A0A8M2BI52
names: Similarity
messages: Belongs to the EPS8 family.

7955:si:dkey-3k24.5
gene id: 7955:si:dkey-3k24.5
uniprot id: E7F240
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the multisubunit TRAPP II complex, which includes at least TRAPPC1, TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC4, TRAPPC5, TRAPPC6A/B, TRAPPC9, TRAPPC10 and TRAPPC14. TRAPPC9, TRAPPC10 and TRAPPC14 are specific subunits of the TRAPP II complex. Interacts with alpha-tubulin during mitosis.
messages: Midbody
messages: Morpholino knockdown of the protein in early embryos results in curved bodies and small eyes. Morphants exhibit reduced ciliation in otic vesicles, neuromasts, and olfactory placodes (PubMed:31467083). In a knockout model mutant animals show head to body ratios lower than those of controls. They have decreased brain cell proliferation rate at 24 hpf (PubMed:30715179).
messages: Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (By similarity). TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is required for ciliogenesis (PubMed:30715179).
messages: Vesicle
messages: spindle

7955:ndufs3
gene id: 7955:ndufs3
uniprot id: Q566S4
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

7955:zgc:165502
gene id: 7955:zgc:165502
uniprot id: A5PLB2
names: Similarity
messages: Belongs to the folate receptor family.

7955:prune
gene id: 7955:prune
uniprot id: A0A8M1NSX6
uniprot id: E7F6P6
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

7955:vgll4b
gene id: 7955:vgll4b
uniprot id: Q6NV03
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

7955:mef2b
gene id: 7955:mef2b
uniprot id: A0A8M3AXP2
uniprot id: J7HE56
names: Subcellular Location Annotation
messages: Nucleus

7955:dus3l
gene id: 7955:dus3l
uniprot id: Q6PEH0
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

7955:kifc3
gene id: 7955:kifc3
uniprot id: A0A8M2B5V3
uniprot id: A0A8M3AJU8
uniprot id: A0A8M3AKN3
uniprot id: A0A8M3AS77
uniprot id: A0A8M3AV59
uniprot id: A0A8M3B361
uniprot id: A0A8M9PAK5
uniprot id: A0A8M9PFZ6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:terf1
gene id: 7955:terf1
uniprot id: A0A8M9PXV3
uniprot id: A0A8N7TFE0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus

7955:LOC100007121
gene id: 7955:LOC100007121
uniprot id: A0A0R4IB59
uniprot id: A0A8M3AS10
uniprot id: A0A8M6YTQ1
uniprot id: A0A8M9PPM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:mogat3a
gene id: 7955:mogat3a
uniprot id: A0A8M9P5P1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:nek9
gene id: 7955:nek9
uniprot id: A0A8M9PLP7
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

7955:pop5
gene id: 7955:pop5
uniprot id: Q5BJI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: nucleolus

7955:v2rh9
gene id: 7955:v2rh9
uniprot id: A0A8M1Q183
uniprot id: A0A8M3AV08
uniprot id: A0A8M6YW75
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:rcor2
gene id: 7955:rcor2
uniprot id: Q6P116
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoREST family.
messages: May act as a component of a corepressor complex that represses transcription.
messages: Nucleus

7955:sypl2a
gene id: 7955:sypl2a
uniprot id: F1Q7F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

7955:cyb5b
gene id: 7955:cyb5b
uniprot id: Q6NY41
names: Similarity
messages: Belongs to the cytochrome b5 family.

7955:LOC795066
gene id: 7955:LOC795066
uniprot id: A0A8M3BA96
names: Similarity
messages: Belongs to the peptidase C14A family.

7955:loxl2b
gene id: 7955:loxl2b
uniprot id: A1L1V4
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Chromosome
messages: Contains 1 lysine tyrosylquinone.
messages: Endoplasmic reticulum
messages: Expression is initiated during early development throughout the notochord and extinguished between 24 and 48 hours after fertilization (PubMed:17543297). At 24 hours after fertilization, expressed ubiquitously throughout the embryo (PubMed:25959397).
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (By similarity). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (By similarity). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (By similarity). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency (By similarity). Involved in epithelial to mesenchymal transition (EMT) and participates in repression of E-cadherin, probably by mediating deamination of histone H3 (By similarity). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (By similarity). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). Required with loxl2a for correct expression of Sox2 and for neural differentiation (PubMed:25959397).
messages: Morpholino knockdown of loxl2a and loxl2b in the embryo results in increased expression of Sox2 in the central nervous system, particularly in the eye, hindbrain and spinal cord. It also leads to impaired neural differentiation with morphological defects in the brain where the anterior brain is rounder than normal and the eyes present a flatter curvature. Embryo development is also compromised.
messages: Nucleus
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: basement membrane

7955:sult4a1
gene id: 7955:sult4a1
uniprot id: Q1RLU6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:appb
gene id: 7955:appb
uniprot id: Q8UUR9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:tbr1a
gene id: 7955:tbr1a
uniprot id: A0A8N7UR48
uniprot id: E7FCP0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:hibadha
gene id: 7955:hibadha
uniprot id: A0A8M3AKW8
uniprot id: A0A8M9PN96
uniprot id: Q6DC72
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

7955:nr1d4a
gene id: 7955:nr1d4a
uniprot id: A0A8M9PKS5
uniprot id: U3M1N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

7955:naa40
gene id: 7955:naa40
uniprot id: A0A8M9QBZ6
uniprot id: Q568K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence'.
messages: Nucleus

7955:tgm1l4
gene id: 7955:tgm1l4
uniprot id: A0A8M9PWI0
uniprot id: Q4V9H9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

7955:rrs1
gene id: 7955:rrs1
uniprot id: Q7SX91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

7955:traf5
gene id: 7955:traf5
uniprot id: A0A8M9PEP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

7955:hmgb1b
gene id: 7955:hmgb1b
uniprot id: X1WFI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

7955:prlrb
gene id: 7955:prlrb
uniprot id: A0A8M2BCV8
uniprot id: A8WH90
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

7955:exosc6
gene id: 7955:exosc6
uniprot id: Q6P0I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family.
messages: Component of the RNA exosome complex.
messages: Cytoplasm
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.
messages: Nucleus
messages: nucleolus

7955:prim1
gene id: 7955:prim1
uniprot id: Q7ZUR8
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

7955:vrk1
gene id: 7955:vrk1
uniprot id: Q7ZUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation. Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Phosphorylates p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.

7955:exosc9
gene id: 7955:exosc9
uniprot id: Q5XJQ5
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family.
messages: Component of the RNA exosome complex.
messages: Cytoplasm
messages: Morpholino knockdown of the protein affects brain and neuromuscular development. Morphant embryos have small heads, small or absent eyes, truncated bodies, and reduced and damaged myofibers. Motor axons fail to migrate properly to the neuromuscular junctions. The brain has abnormal morphology, the cerebellum and hindbrain are absent.
messages: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.
messages: Nucleus
messages: The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active.
messages: nucleolus
messages: nucleoplasm

7955:mtmr12
gene id: 7955:mtmr12
uniprot id: A0A0R4IW75
uniprot id: A0A8M3ASN3
uniprot id: A2BGG1
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an adapter for the myotubularin phosphatase mtm1 to regulate mtm1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing mtm1 protein levels, required for skeletal muscle maintenance but not for myogenesis (PubMed:23818870). In skeletal muscle cells, does not regulate mtm1 subcellular localization (PubMed:23818870).
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 378 in the dsPTPase catalytic loop and does not have phosphatase activity.
messages: At 1 day post fertilization (dpf), expressed ubiquitously in developing eyes, brain, heart and skeletal muscles. Maternally expressed up to 8 hour post fertilization and zygotic expression starts at 1 dpf and continues until 5 dpf.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Heterodimer with lipid phosphatase mtm1 (By similarity). In skeletal muscles, the interaction stabilizes both mtmr12 and mtm1 protein levels (PubMed:23818870).
messages: Morpholino knockdown results in early embryonic mortality between 3 to 5 days post fertilization. Causes a reduction in size with an abnormal dorsal curvature through the back and tail. Impaired motor function characterized by a delay in chorion hatching and a reduced motility. Some animals have pericardial edema. Defects in skeletal muscles including sarcomeric disorganization often with central nucleation and triad disorganization. In skeletal muscles, increased phosphatidylinositol 3-phosphate levels and severe reduction of mtm1 levels without affecting mtm1 subcellular localization. Double morpholino knockdown of mtmr12 and mtm1 results in a more severe phenotype.
messages: Sarcoplasmic reticulum
messages: sarcomere

7955:cct5
gene id: 7955:cct5
uniprot id: Q6NVI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

7955:stk35l
gene id: 7955:stk35l
uniprot id: Q5PRB1
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:cldn15b
gene id: 7955:cldn15b
uniprot id: Q1RLW4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:vps37a
gene id: 7955:vps37a
uniprot id: Q6TH08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

7955:cyp2r1
gene id: 7955:cyp2r1
uniprot id: A0A8N7TDC5
uniprot id: F6P2A1
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:bglap
gene id: 7955:bglap
uniprot id: Q4G6A6
names: Similarity
messages: Belongs to the osteocalcin/matrix Gla protein family.

7955:slc6a1a
gene id: 7955:slc6a1a
uniprot id: A0A8M1NAB5
uniprot id: F1QUY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:fzr1b
gene id: 7955:fzr1b
uniprot id: A0A8M1RLN6
uniprot id: A0A8M2BAA2
uniprot id: E7FF93
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

7955:reck
gene id: 7955:reck
uniprot id: A0A0R4IKU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RECK family.
messages: Cell membrane
messages: Expressed in the cerebral endothelium.
messages: Functions together with adgra2 to enable brain endothelial cells to selectively respond to Wnt7 signals (wnt7a or wnt7b) (PubMed:26051822, PubMed:26657775). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:26051822, PubMed:26657775). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. Adgra2 is then required to deliver reck-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. Also acts as a serine protease inhibitor (By similarity).
messages: Interacts (via knot repeats) with wnt7a (via disordered linker region); the interaction is direct (By similarity). Interacts (via knot repeats) with wnt7b (via disordered linker region); the interaction is direct (By similarity). Interacts with adgra2; the interaction is direct (PubMed:26051822).
messages: The Kazal-like domains mediate the serine protease inhibitor activity.

7955:tlr2
gene id: 7955:tlr2
uniprot id: A0A8M2BI18
uniprot id: F1QWS9
uniprot id: Q6TS42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane

7955:gstm.2
gene id: 7955:gstm.2
uniprot id: A8KBR8
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

7955:ugt1b3
gene id: 7955:ugt1b3
uniprot id: D3XD63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:si:ch211-37e10.2
gene id: 7955:si:ch211-37e10.2
uniprot id: A0A8M2B9P8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:123244
gene id: 7955:zgc:123244
uniprot id: Q32PK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Endosome membrane
messages: Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (By similarity). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (By similarity). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (By similarity).
messages: autophagosome membrane

7955:atp1b1a
gene id: 7955:atp1b1a
uniprot id: Q6NYH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

7955:rpap1
gene id: 7955:rpap1
uniprot id: E7FGQ5
names: Similarity
messages: Belongs to the RPAP1 family.

7955:adora2aa
gene id: 7955:adora2aa
uniprot id: Q29ST6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

7955:msi1
gene id: 7955:msi1
uniprot id: Q5BKV4
names: Similarity
messages: Belongs to the Musashi family.

7955:avpr1aa
gene id: 7955:avpr1aa
uniprot id: A0A059WIL5
uniprot id: E7FH20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:lrp5
gene id: 7955:lrp5
uniprot id: A0A8M3AZI2
uniprot id: D0EWS1
uniprot id: F1QTJ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:86598
gene id: 7955:zgc:86598
uniprot id: A0A8M2B6B1
uniprot id: Q6IQV0
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:LOC556339
gene id: 7955:LOC556339
uniprot id: A0A8M9Q118
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

7955:clcn5b
gene id: 7955:clcn5b
uniprot id: A0A8N7TEL9
uniprot id: E7FFG9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:si:ch211-244c8.4
gene id: 7955:si:ch211-244c8.4
uniprot id: A0A0R4IT13
uniprot id: A0A8M2BKJ4
names: Similarity
messages: Belongs to the Amer family.

7955:rxfp3.3a3
gene id: 7955:rxfp3.3a3
uniprot id: A0A8M9Q6X3
uniprot id: A8E7S9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:ube2t
gene id: 7955:ube2t
uniprot id: Q08BH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in DNA repair.
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Nucleus

7955:tdo2a
gene id: 7955:tdo2a
uniprot id: A7MBU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.

7955:kmt2ca
gene id: 7955:kmt2ca
uniprot id: A0A8M2B9D3
uniprot id: A0A8M2B9E0
uniprot id: A0A8M2B9E8
uniprot id: A0A8M2B9Q2
uniprot id: A0A8M6YWB8
uniprot id: A0A8M6YY65
uniprot id: A0A8M9PG96
names: Subcellular Location Annotation
messages: Nucleus

7955:dbr1
gene id: 7955:dbr1
uniprot id: Q7T3E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function.
messages: Nucleus

7955:frrs1b
gene id: 7955:frrs1b
uniprot id: A0A8M6Z4V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

7955:mhc1zja
gene id: 7955:mhc1zja
uniprot id: A0A8M2BIV1
uniprot id: A7MBX5
names: Similarity
messages: Belongs to the MHC class I family.

7955:thyn1
gene id: 7955:thyn1
uniprot id: A0A8M1PEU1
uniprot id: F1QDP5
names: Function
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

7955:camkk1a
gene id: 7955:camkk1a
uniprot id: A0A8M2BJ67
uniprot id: A0A8M2BJ77
uniprot id: A2BIP2
uniprot id: Q58EH5
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:ank3b
gene id: 7955:ank3b
uniprot id: A0A8M3AY24
uniprot id: A0A8M3AY49
uniprot id: A0A8M3B4F1
uniprot id: A0A8M3BE06
uniprot id: A0A8M9PWQ8
uniprot id: A0A8M9PWR2
uniprot id: A0A8M9PWR7
uniprot id: A0A8M9PWS1
uniprot id: A0A8M9PWS5
uniprot id: A0A8M9PWS8
uniprot id: A0A8M9PWT3
uniprot id: A0A8M9Q8S7
uniprot id: A0A8M9Q8T2
uniprot id: A0A8M9Q8T6
uniprot id: A0A8M9Q8U7
uniprot id: A0A8M9Q8V2
uniprot id: A0A8M9Q8V7
uniprot id: A0A8M9QEJ1
uniprot id: A0A8M9QEJ4
uniprot id: A0A8M9QEJ7
uniprot id: A0A8M9QEK1
uniprot id: A0A8M9QEK3
uniprot id: A0A8M9QEK7
uniprot id: A0A8M9QEL0
uniprot id: A0A8M9QEL4
uniprot id: A0A8M9QJ00
uniprot id: A0A8M9QJ05
uniprot id: A0A8M9QJ09
uniprot id: A0A8M9QJ14
uniprot id: A0A8M9QJ17
uniprot id: A0A8M9QJ21
uniprot id: A0A8M9QJ22
uniprot id: A0A8M9QMR8
uniprot id: A0A8M9QMS1
uniprot id: A0A8M9QMS4
uniprot id: A0A8M9QMS8
uniprot id: A0A8M9QMT2
uniprot id: A0A8M9QMT4
uniprot id: A0A8M9QMT9
uniprot id: A0A8M9QMU2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:crtc1
gene id: 7955:crtc1
uniprot id: A0A8M2BK37
uniprot id: F1QYY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

7955:ltb4r2b
gene id: 7955:ltb4r2b
uniprot id: A0A8M1P208
uniprot id: E7F4K9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:pkd1b
gene id: 7955:pkd1b
uniprot id: A0A8M9QJ55
uniprot id: A0A8M9QMX0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:tpst2
gene id: 7955:tpst2
uniprot id: A0A8M9QKK3
uniprot id: Q7T295
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

7955:si:dkey-17o15.2
gene id: 7955:si:dkey-17o15.2
uniprot id: A0A8M9PK10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

7955:prdm1b
gene id: 7955:prdm1b
uniprot id: A0A8M3AL91
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:mfng
gene id: 7955:mfng
uniprot id: B2GP22
uniprot id: Q5YB40
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: First detected at the 12-somite stage. From the 20-somite stage, expressed in the otic vesicle.
messages: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules.
messages: Golgi apparatus membrane
messages: Membrane

7955:zgc:112185
gene id: 7955:zgc:112185
uniprot id: Q5BJC4
names: Similarity
messages: Belongs to the UPF0488 family.

7955:arsb
gene id: 7955:arsb
uniprot id: A0A8M9PII1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7955:ccdc61
gene id: 7955:ccdc61
uniprot id: Q08CF3
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC61 family.
messages: Forms homodimers (via head domain).
messages: Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Plays a non-essential role in ciliogenesis.
messages: The N-terminal 3D structure (head domain) resembles that of NHEJ1/XLF, PAXX, SASS6 and XRCC4.
messages: The coiled-coil domain is involved in microtubule-binding.
messages: centriolar satellite
messages: centrosome
messages: cilium basal body

7955:cplx3a
gene id: 7955:cplx3a
uniprot id: D2K289
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

7955:tcf7l2
gene id: 7955:tcf7l2
uniprot id: Q71G54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

7955:ppp1cbl
gene id: 7955:ppp1cbl
uniprot id: Q7T313
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm

7955:sin3b
gene id: 7955:sin3b
uniprot id: B7ZV87
uniprot id: Q1LYM8
names: Subcellular Location Annotation
messages: Nucleus

7955:med18
gene id: 7955:med18
uniprot id: Q7T3H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:kat7b
gene id: 7955:kat7b
uniprot id: A0A8M9QIK1
uniprot id: Q7ZW29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

7955:cebpd
gene id: 7955:cebpd
uniprot id: Q8UVY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

7955:LOC108191508
gene id: 7955:LOC108191508
uniprot id: A0A8M6Z8H8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:LOC108180736
gene id: 7955:LOC108180736
uniprot id: Q2PR90
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:men1
gene id: 7955:men1
uniprot id: Q9IAA9
names: Subcellular Location Annotation
messages: Nucleus

7955:lmbr1
gene id: 7955:lmbr1
uniprot id: A0A0R4IR97
uniprot id: A0A8M1P2F0
uniprot id: A0A8M2BDY2
names: Similarity
messages: Belongs to the LIMR family.

7955:nt5c2a
gene id: 7955:nt5c2a
uniprot id: A0A8M2B3I7
uniprot id: A0A8M9QJJ3
uniprot id: E7FC21
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

7955:si:dkey-83h2.2
gene id: 7955:si:dkey-83h2.2
uniprot id: A0A8M3B0N9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:rbfox3b
gene id: 7955:rbfox3b
uniprot id: A0A8M6YZ68
uniprot id: A0A8M9PBK2
uniprot id: A0A8M9PBK7
uniprot id: A0A8M9PBL0
uniprot id: A0A8M9PN39
uniprot id: A0A8M9Q1D6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

7955:slc15a1a
gene id: 7955:slc15a1a
uniprot id: A0A8M9QB23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

7955:parp6b
gene id: 7955:parp6b
uniprot id: A0A8M6Z4I1
uniprot id: F1R1Q8
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:igf1ra
gene id: 7955:igf1ra
uniprot id: A0A8M6YTF7
uniprot id: A0A8N7UZS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:tulp4a
gene id: 7955:tulp4a
uniprot id: A0A8M2BFT7
uniprot id: A0A8M6YZI4
uniprot id: A0A8N7UYA6
uniprot id: E7EXF2
uniprot id: F6NJC6
names: Similarity
messages: Belongs to the TUB family.

7955:kcnh1a
gene id: 7955:kcnh1a
uniprot id: A0A8M3AJ13
uniprot id: A0A8M3ARE9
uniprot id: A0A8M3B2G4
uniprot id: A0A8M9PEA3
uniprot id: Q108P3
names: Subcellular Location Annotation
messages: Membrane

7955:bcl2l10
gene id: 7955:bcl2l10
uniprot id: Q8UWD5
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:park2
gene id: 7955:park2
uniprot id: Q561U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Parkin subfamily.
messages: Forms an E3 ubiquitin ligase complex.
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Mitochondrion
messages: cytosol

7955:ap2m1a
gene id: 7955:ap2m1a
uniprot id: A0A8M1P618
uniprot id: F1Q9V1
uniprot id: Q6NWK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids (By similarity).
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

7955:ncaldb
gene id: 7955:ncaldb
uniprot id: Q6AXL4
names: Function
names: Similarity
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).

7955:tigarb
gene id: 7955:tigarb
uniprot id: Q7ZVE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoglycerate mutase family.
messages: Cytoplasm
messages: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May play a role in mitophagy inhibition.
messages: Mitochondrion
messages: Not expected to have any kinase activity.
messages: Nucleus

7955:epd
gene id: 7955:epd
uniprot id: P17561
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ependymin family.
messages: Binds calcium through the terminal sialic acids.
messages: EPDs are synthesized in the meninx and secreted in the cerebrospinal fluid.
messages: Forms disulfide-linked dimers.
messages: May play a role in neural plasticity. May be involved during axon regeneration.
messages: Secreted

7955:LOC101884976
gene id: 7955:LOC101884976
uniprot id: A0A8M2B2S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:si:dkey-221h15.4
gene id: 7955:si:dkey-221h15.4
uniprot id: A0A8M6Z2U9
uniprot id: F1QS94
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:nt5dc1
gene id: 7955:nt5dc1
uniprot id: A0A8M9PHH6
uniprot id: A7MBY0
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

7955:pgm2l1
gene id: 7955:pgm2l1
uniprot id: B7ZVE8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

7955:atp5h
gene id: 7955:atp5h
uniprot id: A7E2P8
uniprot id: Q6PC77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

7955:si:ch211-113a14.11
gene id: 7955:si:ch211-113a14.11
uniprot id: Q4FZZ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:pcmt
gene id: 7955:pcmt
uniprot id: A0A8M2B749
uniprot id: Q92047
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.
messages: Monomer.
messages: cytosol

7955:vtg3
gene id: 7955:vtg3
uniprot id: A0A8M1P7D8
uniprot id: F1QQQ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:kiaa1024l
gene id: 7955:kiaa1024l
uniprot id: A0A8M9QLE1
names: Similarity
messages: Belongs to the MINAR family.

7955:si:ch1073-159d7.11
gene id: 7955:si:ch1073-159d7.11
uniprot id: F1QTL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:LOC571124
gene id: 7955:LOC571124
uniprot id: A0A8M3ATA4
uniprot id: A0A8N7UVP8
uniprot id: F1QV70
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:pmvk
gene id: 7955:pmvk
uniprot id: A4IGD4
names: Subcellular Location Annotation
messages: cytosol

7955:adnp2a
gene id: 7955:adnp2a
uniprot id: A4QP16
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed from the 1-cell stage, before the onset of zygotic expression, then, during gastrulation, at 6 hours post-fertilization (hpf), expression is absent, and at 11-12 hpf, coincident with segmentation, expression returns until 72 hpf.
messages: May be involved in transcriptional regulation (PubMed:23071114). Required for progression through late erythroid differentiation (PubMed:23071114). May be involved in vasculogenesis (PubMed:23071114).
messages: Morpholino knockdown has no effect on overall morphology, and at the onset of blood circulation at 24 hours post-fertilization (hpf), blood cells are present, however between 33 and 48 hpf, blood cells are absent, and embryos develop cardiac edema (PubMed:23071114). Hemoglobin undetectable (PubMed:23071114). Some embryos recovered blood circulation at day 4 after knockdown, whereas others became severely edematous at day 4-5 and died by about 7 days (PubMed:23071114). At 28 and 48 hpf, expression of band3 almost abolished; embryonic alpha-globin1 also significantly reduced at 28 hpf (PubMed:23071114).
messages: Nucleus

7955:fign
gene id: 7955:fign
uniprot id: A0A8M9QFE1
uniprot id: B2GQM4
uniprot id: Q503S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity).
messages: Belongs to the AAA ATPase family.
messages: Nucleus matrix
messages: centrosome

7955:pnkd
gene id: 7955:pnkd
uniprot id: A0A8M1P2H3
uniprot id: F6NM08
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

7955:slc19a3a
gene id: 7955:slc19a3a
uniprot id: A0A8N7TAR4
uniprot id: E7F6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

7955:cdadc1
gene id: 7955:cdadc1
uniprot id: A0A8M2BIB1
uniprot id: A0A8M2BIC9
uniprot id: F8W4G5
uniprot id: Q5U3U4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Catalyzes the deamination of cytidine and deoxycytidine into uridine and deoxyuridine, respectively.

7955:cox7b
gene id: 7955:cox7b
uniprot id: B3DJA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:mhc1zea
gene id: 7955:mhc1zea
uniprot id: A0A8M2BIB4
uniprot id: A0A8M6YZS6
uniprot id: A8E7F2
uniprot id: Q7YP14
uniprot id: U6BQV3
names: Similarity
messages: Belongs to the MHC class I family.

7955:cx30.9
gene id: 7955:cx30.9
uniprot id: Q6DEG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:si:ch211-163l21.7
gene id: 7955:si:ch211-163l21.7
uniprot id: A8Y5T1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity). May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis (By similarity).
messages: cilium axoneme
messages: cytoskeleton

7955:si:ch73-281n10.2
gene id: 7955:si:ch73-281n10.2
uniprot id: A0A0R4IWN8
uniprot id: A0A8M1P7Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

7955:LOC100332191
gene id: 7955:LOC100332191
uniprot id: A0A8M9Q401
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

7955:slc44a4
gene id: 7955:slc44a4
uniprot id: Q7T2B0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the CTL (choline transporter-like) family.
messages: Choline transporter that seems to play a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury.
messages: Gene expression gradually increases from 36 to 96 hours post-fertilization (hpf). At 12 hpf, expressed broadly, but at 26 hpf, the expression clusters around the otic vesicle, pectoral fin, and midbrain.
messages: Membrane
messages: Morpholino knockdown of the protein causes abnormal numbers of small, fused, and misplaced otoliths, and a smaller inner ear. Neuromasts of the morphants are smaller, and the number of lateral line neuromasts in the morphants is fewer than in the wild-type. Fewer hair cells per neuromast are found in both the anterior and posterior line of morpholino knockdown larvae (120 hpf) than in the wild-type. Knockdown larvae have a defective balance system, they show an abnormal swimming behavior by remaining stationary and resting in abnormal positions, they swim up and down and in circles. They also show some hearing loss.

7955:slc2a11l
gene id: 7955:slc2a11l
uniprot id: A1A5Y3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:arrdc1b
gene id: 7955:arrdc1b
uniprot id: A0A8N7TBT1
names: Similarity
messages: Belongs to the arrestin family.

7955:ppp1r14ab
gene id: 7955:ppp1r14ab
uniprot id: A0A8M9QLB3
uniprot id: Q6PBJ4
names: Similarity
messages: Belongs to the PP1 inhibitor family.

7955:dmrt2a
gene id: 7955:dmrt2a
uniprot id: Q9W7K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

7955:ryr1b
gene id: 7955:ryr1b
uniprot id: A0A8M6YTI2
uniprot id: A0A8M6YTI9
uniprot id: A0A8M6YU63
uniprot id: A0A8M6YVZ9
uniprot id: A0A8M6Z1Y4
uniprot id: A0A8M6Z1Y9
uniprot id: A0A8M6Z2L8
uniprot id: A0A8M9PA63
uniprot id: A0A8M9PFJ3
uniprot id: A0A8M9PM90
uniprot id: A0A8M9PQC8
uniprot id: A6P4B8
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:wdyhv1
gene id: 7955:wdyhv1
uniprot id: Q1LWX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.
messages: Nucleus
messages: cytosol

7955:ubxn1
gene id: 7955:ubxn1
uniprot id: Q6NXA9
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: The UBA domain specifically recognizes and binds 'Lys-6'-linked polyubiquitin chains.
messages: Ubiquitin-binding protein that specifically binds 'Lys-6'-linked polyubiquitin chains. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems (By similarity).

7955:mb21d2
gene id: 7955:mb21d2
uniprot id: A0A8N7T7M9
uniprot id: B8JLG8
names: Similarity
messages: Belongs to the mab-21 family.

7955:ybx1
gene id: 7955:ybx1
uniprot id: B5DE31
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YBX1 family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation (PubMed:30135188, PubMed:31399345). Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:31399345). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting pabpc1a, thereby preventing mRNA decay (PubMed:31399345). Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation (PubMed:31399345). Also promotes maternal-to-zygotic transition in oocytes and embryos by promoting translation repression; molecular mechanisms governing translation repression are unknown (PubMed:30135188). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs. Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Also able to bind DNA and regulate transcription. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity).
messages: Embryonic lethality caused by early gastrulation arrest: maternal mutant embryos fail to undergo normal cleavage and the maternal-to-zygotic transition (PubMed:30135188, PubMed:31399345). Early embryos show severe developmental arrest at the shield stage in maternal ybx1 knockout embryos, leading to lethality at 8 hours post-fertilization (hpf) (PubMed:31399345).
messages: Expressed both maternally and zygotically.
messages: In the CSD domain, Trp-45 specifically recognizes C5-methylcytosine (m5C) modification through its indole ring.
messages: Interacts with pabpc1a; leading to pabpc1a recruitment on C5-methylcytosine (m5C)-containing mRNAs.
messages: Nucleus
messages: Secreted
messages: extracellular exosome

7955:zgc:56106
gene id: 7955:zgc:56106
uniprot id: Q7ZVC9
names: Similarity
messages: Belongs to the SMAP family.

7955:ntrk3a
gene id: 7955:ntrk3a
uniprot id: A0A8M1P2M2
uniprot id: F1QKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:tekt4
gene id: 7955:tekt4
uniprot id: A0A8M1NTB8
uniprot id: B8A4G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

7955:glra1
gene id: 7955:glra1
uniprot id: A0A8M9QAU4
uniprot id: B3DHZ5
uniprot id: O93430
uniprot id: Q8QG93
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by glycine and taurine. Inhibited by strychnine (PubMed:10188956, PubMed:26344198). Allosterically activated by ivermectin (PubMed:26344198). Inhibited by picrotoxinin (PubMed:26344198). Strychnine binding locks the channel in a closed conformation and prevents channel opening in response to extracellular glycine (PubMed:26344198). Can also be activated by GABA and inhibited by bicuculline, but this requires heterologous expression in human cells (PubMed:10188956).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Expressed in brain.
messages: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:10188956, PubMed:26344198). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity).
messages: Highly sensitive to activation by taurine despite the presence of Val in position 135. In mammals, Val-135 causes a drastic loss of taurine efficacy.
messages: Homopentamer (in vitro) (PubMed:26344198). Heteropentamer composed of glra1 and glrb (By similarity). Both homopentamers and heteropentamers form functional ion channels (By similarity).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: The alpha subunit binds strychnine.
messages: The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits. Channel opening is effected by an outward rotation of the transmembrane domains that increases the diameter of the pore.
messages: dendrite

7955:npc1
gene id: 7955:npc1
uniprot id: A0A0R4IZV0
uniprot id: A0A2R8Q2J0
uniprot id: A0A8M1P234
uniprot id: A0A8M2BAS9
uniprot id: A0A8M2BAZ2
uniprot id: F1QNG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

7955:apoda.1
gene id: 7955:apoda.1
uniprot id: A0A8M1NAX4
uniprot id: F1R0I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

7955:retreg3
gene id: 7955:retreg3
uniprot id: A0A8N7UVZ1
uniprot id: F1QYM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

7955:LOC556363
gene id: 7955:LOC556363
uniprot id: A0A8M9QD89
names: Subcellular Location Annotation
messages: Membrane

7955:cpe
gene id: 7955:cpe
uniprot id: Q6NSM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Membrane
messages: secretory vesicle membrane

7955:otogl
gene id: 7955:otogl
uniprot id: A0A8M9P1M2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tomm7
gene id: 7955:tomm7
uniprot id: Q0P4E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:pln
gene id: 7955:pln
uniprot id: A0A8M1P2H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Sarcoplasmic reticulum membrane

7955:hnf4a
gene id: 7955:hnf4a
uniprot id: A0A8M9P510
uniprot id: A0A8M9PEX6
uniprot id: A0A8M9PKL5
uniprot id: A0A8M9PSX4
uniprot id: A8E5K2
uniprot id: Q8AXB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:v2rx3
gene id: 7955:v2rx3
uniprot id: A0A8M3AJP9
uniprot id: A0A8M3AKI9
uniprot id: A0A8M3AS25
uniprot id: A0A8M3AUZ8
uniprot id: A0A8M3B311
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:sdhaf4
gene id: 7955:sdhaf4
uniprot id: Q6ZM41
names: Similarity
messages: Belongs to the SDHAF4 family.

7955:kdm4c
gene id: 7955:kdm4c
uniprot id: A2RRT0
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

7955:LOC101884567
gene id: 7955:LOC101884567
uniprot id: A0A8M9PU89
names: Similarity
messages: Belongs to the MAGUK family.

7955:sox21a
gene id: 7955:sox21a
uniprot id: Q7SZS1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically. Expressed in oocytes and throughout embryogenesis, whereas expression in adults is undetectable.
messages: Expressed in all cells until gastrulation, becoming restricted to the developing central nervous system later, where expression is in the forebrain, midbrain and hindbrain but maximally at the midbrain-hindbrain boundary.
messages: May function as a switch in neuronal development (By similarity). Acts as a negative regulator of transcription. Plays a role in dorsoventral patterning of the embryo.
messages: Nucleus
messages: Ventralized embryos.

7955:zgc:92630
gene id: 7955:zgc:92630
uniprot id: A0A8M2B496
uniprot id: F1QDB3
uniprot id: Q6DH64
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:parvaa
gene id: 7955:parvaa
uniprot id: B2GP46
uniprot id: Q6DRM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: cytoskeleton

7955:zdhhc5a
gene id: 7955:zdhhc5a
uniprot id: A0A8M2B728
uniprot id: A0A8M2B731
uniprot id: A0A8M2B739
uniprot id: A0A8M3ARQ1
uniprot id: Q2THW0
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Cell membrane
messages: Membrane
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes.
messages: Probably maternally supplied, the zygotic expression is detected early during development at the 512-cell stage.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:pcmtl
gene id: 7955:pcmtl
uniprot id: A0A8M2B570
uniprot id: F1QL05
uniprot id: Q6PBS7
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

7955:cmss1
gene id: 7955:cmss1
uniprot id: Q5XJK9
names: Similarity
messages: Belongs to the CMS1 family.

7955:gpr101
gene id: 7955:gpr101
uniprot id: A0A8M2BL08
uniprot id: E7FA10
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:zc3h18
gene id: 7955:zc3h18
uniprot id: Q1LUE5
names: Subcellular Location Annotation
messages: Nucleus

7955:bcl9l
gene id: 7955:bcl9l
uniprot id: A0A8M2B5R5
uniprot id: A0A8M2B5V0
uniprot id: F8W4Z7
uniprot id: Q67FY3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Highly expressed during gastrulation.
messages: Nucleus
messages: Severe defects of trunk and tail development.
messages: Transcriptional regulator that may act as an activator (By similarity). Plays a role for mesoderm patterning in early embryogenesis.

7955:cox5aa
gene id: 7955:cox5aa
uniprot id: Q4VBU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

7955:marveld2b
gene id: 7955:marveld2b
uniprot id: A0A8M9Q3L6
uniprot id: A2BGQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:elavl1
gene id: 7955:elavl1
uniprot id: A0A8M2BIL8
uniprot id: F1QM02
uniprot id: Q9PTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

7955:cxadr
gene id: 7955:cxadr
uniprot id: Q90Y50
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Cell membrane
messages: May function as a homophilic cell adhesion molecule and be essential for tight junction integrity. May also be involved in transepithelial migration of leukocytes through adhesive interactions with jaml. The interaction between both receptors may also mediate the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair (By similarity).
messages: Monomer. Probably homodimer formed by 2 molecules on adjacent cells (By similarity).
messages: The Ig-like C2-type 1 domain may mediate homodimerization.
messages: adherens junction
messages: tight junction

7955:cd151
gene id: 7955:cd151
uniprot id: A0A8M2BLG9
uniprot id: Q5XJD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:slc39a4
gene id: 7955:slc39a4
uniprot id: A0A8M6Z2D9
uniprot id: B3DKI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

7955:brms1la
gene id: 7955:brms1la
uniprot id: A0A8M2B545
uniprot id: A0A8M2B5J3
uniprot id: A0A8M3AU24
uniprot id: A0A8M9P094
uniprot id: Q4V8V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRMS1 family.
messages: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity.
messages: Nucleus

7955:si:dkey-205h13.1
gene id: 7955:si:dkey-205h13.1
uniprot id: A0A8M9P550
uniprot id: E7F188
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

7955:hoxb3a
gene id: 7955:hoxb3a
uniprot id: A0A8M9P483
uniprot id: O42368
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: First expressed at the 1- to 2-somite stages posterior to rhombomere 5 (r5) of the developing hindbrain. By the 3- to 4-somite stages, the anterior expression limit is at the r4/r5 boundary. At 5- to 10-somite stages, expressed at high levels in r5 and r6. From the 20- to 30-somite stages, expressed weakly in r4.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:gatsl3
gene id: 7955:gatsl3
uniprot id: Q58ER9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

7955:LOC100149227
gene id: 7955:LOC100149227
uniprot id: A0A0G2KUY7
uniprot id: A0A8M1RLM4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:LOC100536206
gene id: 7955:LOC100536206
uniprot id: A0A8M9Q4E6
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

7955:ninj2
gene id: 7955:ninj2
uniprot id: A0A8M1P925
uniprot id: A0A8M9Q638
uniprot id: E7FE82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

7955:LOC100151419
gene id: 7955:LOC100151419
uniprot id: A0A8M1QKQ6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

7955:cavin1b
gene id: 7955:cavin1b
uniprot id: A6NA21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

7955:cdh8
gene id: 7955:cdh8
uniprot id: A0A8M6Z1S0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

7955:wu:fb69f10
gene id: 7955:wu:fb69f10
uniprot id: A0A8M1RHZ7
uniprot id: A0A8M2BHP8
uniprot id: A0A8M2BI38
uniprot id: F1Q618
names: Similarity
messages: Belongs to the RRM Spen family.

7955:dcst1
gene id: 7955:dcst1
uniprot id: A0A8M6YVA5
names: Subcellular Location Annotation
messages: Membrane

7955:chmp2bb
gene id: 7955:chmp2bb
uniprot id: Q6NXD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF7 family.
messages: Late endosome membrane
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).
messages: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome (By similarity).
messages: cytosol

7955:alpi.1
gene id: 7955:alpi.1
uniprot id: A0A8M3B5T5
uniprot id: Q58EF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

7955:etf1b
gene id: 7955:etf1b
uniprot id: Q803E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

7955:hmbox1a
gene id: 7955:hmbox1a
uniprot id: A0A8M2BH49
uniprot id: A0A8M2BH68
uniprot id: A0A8M3AU36
uniprot id: A0A8M9PKV6
uniprot id: A0A8M9PNW0
uniprot id: Q4V904
names: Subcellular Location Annotation
messages: Nucleus

7955:chrnb2a
gene id: 7955:chrnb2a
uniprot id: A0A8M3B0F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:nrn1la
gene id: 7955:nrn1la
uniprot id: A0A8M1P2J5
uniprot id: F1QK42
names: Similarity
messages: Belongs to the neuritin family.

7955:gig2h
gene id: 7955:gig2h
uniprot id: F2WZ32
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:fam19a1a
gene id: 7955:fam19a1a
uniprot id: A0A8M1RN33
uniprot id: A0A8M2B8Z7
uniprot id: A0A8M2B996
names: Similarity
messages: Belongs to the TAFA family.

7955:zgc:65895
gene id: 7955:zgc:65895
uniprot id: Q6NZS2
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

7955:chrnb4
gene id: 7955:chrnb4
uniprot id: A0A0R4ISQ3
uniprot id: A0A8N7TBN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:tmem91
gene id: 7955:tmem91
uniprot id: A0A8M3AKK5
uniprot id: A0A8M9PPP4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:il12bb
gene id: 7955:il12bb
uniprot id: A0A8M9PV11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-12B family.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

7955:smpdl3a
gene id: 7955:smpdl3a
uniprot id: A0A8M2BHJ3
uniprot id: A0A8M3AWG3
uniprot id: Q58EN0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

7955:anapc13
gene id: 7955:anapc13
uniprot id: E7FFM7
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

7955:gpc3
gene id: 7955:gpc3
uniprot id: Q6V9Y8
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway (By similarity). Positively regulates the canonical and non-canonical Wnt signaling pathways (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development (By similarity). Modulates the effects of growth factors on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (PubMed:14610063).
messages: Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor (PubMed:14610063). This processing is essential for its role in inhibition of hedgehog signaling (By similarity). A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface (By similarity).
messages: Heterodimer; disulfide-linked. Cleavage by a furin-like convertase results in production of alpha and beta chains which form a disulfide-linked heterodimer.
messages: Maternally expressed and is almost ubiquitous during blastula and gastrula stages but becomes restricted to the prospective hindbrain by 24 hours post-fertilization.
messages: Morpholino knockdown results in severe defects during epiboly with most embryos arrested at 60-80% epiboly.
messages: O-glycosylated; contains heparan sulfate.

7955:nr6a1b
gene id: 7955:nr6a1b
uniprot id: Q4V8R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR6 subfamily.
messages: Homodimer.
messages: Nucleus
messages: Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' (By similarity).

7955:trpv4
gene id: 7955:trpv4
uniprot id: A0A8M2BCE0
uniprot id: A0A8M2BCH8
uniprot id: Q0PEH1
names: Subcellular Location Annotation
messages: Membrane

7955:aip
gene id: 7955:aip
uniprot id: Q90ZC5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.
messages: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

7955:nfe2l1a
gene id: 7955:nfe2l1a
uniprot id: A0A8M9PL74
uniprot id: B3DGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. CNC subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

7955:mgat1b
gene id: 7955:mgat1b
uniprot id: A0A2R8Q4I1
uniprot id: A0A8M2BHC3
uniprot id: A0A8M2BHT2
uniprot id: A0JMK2
uniprot id: A3KQ03
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

7955:kcnk2a
gene id: 7955:kcnk2a
uniprot id: A0A8M9P0N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:dna2
gene id: 7955:dna2
uniprot id: A0A8M9PSF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

7955:LOC101886719
gene id: 7955:LOC101886719
uniprot id: A0A8M3B0B3
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch211-51a6.2
gene id: 7955:si:ch211-51a6.2
uniprot id: A0A8N7UV83
uniprot id: F1QX88
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

7955:fmn1
gene id: 7955:fmn1
uniprot id: A0A8N7UUW0
names: Similarity
messages: Belongs to the formin homology family. Cappuccino subfamily.

7955:etv1
gene id: 7955:etv1
uniprot id: A0A8M2B3T9
uniprot id: B3DIF9
uniprot id: Q4VCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:si:ch1073-287p18.1
gene id: 7955:si:ch1073-287p18.1
uniprot id: A0A8M1NT22
uniprot id: A0A8M3ALU3
uniprot id: B8JMG5
uniprot id: B8JMG6
names: Similarity
messages: Belongs to the UPF0598 family.

7955:prim2
gene id: 7955:prim2
uniprot id: A0A8M6Z9J9
uniprot id: B8JIP2
uniprot id: Q6TGV8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

7955:pfdn1
gene id: 7955:pfdn1
uniprot id: Q5D016
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

7955:zgc:92137
gene id: 7955:zgc:92137
uniprot id: Q6DHR7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

7955:si:ch211-74m13.3
gene id: 7955:si:ch211-74m13.3
uniprot id: A0A8M1RDF3
uniprot id: A0A8M2BBT6
uniprot id: B8JHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

7955:LOC566907
gene id: 7955:LOC566907
uniprot id: F2WZ37
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:smg7
gene id: 7955:smg7
uniprot id: Q1LVF3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed during early cleavage, gastrulation and at 1 day post-fertilization.
messages: Morpholino knockdown leads to a phenotype ranging in severity from weak to severe that includes an elongated hindbrain, altered midbrain-hindbrain boundary, stacked somites in severe phenotypes and a mortality rate of 97% at 5 days post-fertilization.
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay (By similarity). Recruits UPF1 to cytoplasmic mRNA decay bodies (By similarity). Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). Required for normal embryonic development (PubMed:19414594).

7955:svbp
gene id: 7955:svbp
uniprot id: P0C8M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Cytoplasm
messages: Enhances the tyrosine carboxypeptidase activity of vash1 and vash2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of vash1 and vash2. May play a role in axon and excitatory synapse formation (By similarity).
messages: Secreted
messages: cytoskeleton

7955:cep57l1
gene id: 7955:cep57l1
uniprot id: A0A8M1N1U1
uniprot id: A0A8M2B7K9
names: Similarity
messages: Belongs to the translokin family.

7955:si:dkey-148a17.5
gene id: 7955:si:dkey-148a17.5
uniprot id: A0A0U4AUM5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:cdk14
gene id: 7955:cdk14
uniprot id: A0A8M9PD73
uniprot id: A0A8M9PMK5
uniprot id: A8WG02
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:dkey-16n15.6
gene id: 7955:si:dkey-16n15.6
uniprot id: A0A8M6Z2F3
names: Subcellular Location Annotation
messages: Membrane

7955:tram1
gene id: 7955:tram1
uniprot id: Q6P4U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

7955:tshz3a
gene id: 7955:tshz3a
uniprot id: A0A8N7UV21
uniprot id: F1QL82
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

7955:nampta
gene id: 7955:nampta
uniprot id: A0A8M1RH67
uniprot id: E7F8T6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

7955:ncstn
gene id: 7955:ncstn
uniprot id: Q5XLR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

7955:pop7
gene id: 7955:pop7
uniprot id: Q5XJ22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like Alba family.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: nucleolus

7955:jagn1b
gene id: 7955:jagn1b
uniprot id: Q1L864
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function.

7955:gdf5
gene id: 7955:gdf5
uniprot id: A0A8M1RDK8
uniprot id: F1QK08
names: Similarity
messages: Belongs to the TGF-beta family.

7955:sult5a1
gene id: 7955:sult5a1
uniprot id: A0A8M6Z770
uniprot id: F1QV04
uniprot id: Q08C30
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:c1qtnf12
gene id: 7955:c1qtnf12
uniprot id: A1A5X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adipolin/erythroferrone family.
messages: Homomultimer; disulfide-linked.
messages: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue.
messages: Secreted

7955:nhsa
gene id: 7955:nhsa
uniprot id: A0A8M1QKA2
uniprot id: A0A8M9PLD5
uniprot id: A0A8M9PTR0
uniprot id: A0A8M9PX19
names: Similarity
messages: Belongs to the NHS family.

7955:ccdc135
gene id: 7955:ccdc135
uniprot id: A0A8M3AWI7
uniprot id: A0A8M9PYW2
uniprot id: E7FF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

7955:si:ch73-22a13.3
gene id: 7955:si:ch73-22a13.3
uniprot id: A0A8M3B8D9
uniprot id: A0A8M9QBA1
uniprot id: F1QPV9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:slc9a5
gene id: 7955:slc9a5
uniprot id: A9XPA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

7955:papolg
gene id: 7955:papolg
uniprot id: A0A8M2B2U5
uniprot id: A0A8M2B2X0
uniprot id: A0A8M2B3J2
uniprot id: A2BGL0
uniprot id: Q6PGV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

7955:ikbkb
gene id: 7955:ikbkb
uniprot id: A0A8M1NIE6
uniprot id: B0R199
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:alkbh5
gene id: 7955:alkbh5
uniprot id: Q08BA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkB family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:24561204). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:24561204).
messages: Monomer.
messages: Nucleus speckle

7955:rorb
gene id: 7955:rorb
uniprot id: A3R3J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:mgst1.1
gene id: 7955:mgst1.1
uniprot id: Q5XJJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

7955:acadm
gene id: 7955:acadm
uniprot id: A0A8M1PII2
uniprot id: A2CG95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

7955:e2f7
gene id: 7955:e2f7
uniprot id: Q5RIX9
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator and promoting expression of vegfa.
messages: Belongs to the E2F/DP family.
messages: Embryos lacking both e2f7 and e2f8 contain multiple intersegmental arteries that completely fail to migrate from the dorsal aorta. Gross morphology of these embryos and initial formation of main axial vessels are unaltered.
messages: Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with e2f8.
messages: In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).
messages: Nucleus

7955:tpd52l2a
gene id: 7955:tpd52l2a
uniprot id: A0A2R8QN88
uniprot id: A0A8M1P413
uniprot id: A0A8M1P523
uniprot id: A0A8M2BEH5
uniprot id: A0A8M3B1Z0
uniprot id: A0A8M9Q9I8
uniprot id: E9QF87
uniprot id: E9QG97
uniprot id: Q803K5
names: Similarity
messages: Belongs to the TPD52 family.

7955:actr3b
gene id: 7955:actr3b
uniprot id: A0A8M2B9D0
uniprot id: A0A8M3AVU7
uniprot id: A0A8M9PLJ7
uniprot id: A2VD47
names: Similarity
messages: Belongs to the actin family.

7955:pmpca
gene id: 7955:pmpca
uniprot id: Q5U3T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

7955:zgc:173594
gene id: 7955:zgc:173594
uniprot id: A7YYB6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

7955:mpv17
gene id: 7955:mpv17
uniprot id: Q5TZ51
names: Disease Annotation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Genetic defects resulting in MPV17 loss are responsible for the transparent (tra) mutant phenotype. 'tra' fishes display pigmentation abnormalities and lack of cells derived from the neural crest, such as iridophores and, at later stages of development, melanophores (PubMed:23862018). MPV17-null larvae show disruption of mitochondrial ultrastructure in liver cells with mitochondrial ballooning and disappearance of cristae, and impaired oxidative phosphorylation, insufficient pyrimidine synthesis, and mtDNA depletion (PubMed:30833296).
messages: Involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (PubMed:30833296). Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress (By similarity).
messages: Mitochondrion inner membrane
messages: Widely expressed.

7955:nhsb
gene id: 7955:nhsb
uniprot id: A0A8M3AXP9
uniprot id: A0A8M3AXS7
uniprot id: A0A8M3BDS0
uniprot id: A0A8M9PVJ7
uniprot id: A0A8M9Q7R9
uniprot id: A0A8M9QDP4
uniprot id: A0A8M9QM22
names: Similarity
messages: Belongs to the NHS family.

7955:paqr5b
gene id: 7955:paqr5b
uniprot id: A0A8M3AU91
uniprot id: F1QL89
uniprot id: Q6DC77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane
messages: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity).

7955:ndufaf2
gene id: 7955:ndufaf2
uniprot id: A0A8M1NHA3
uniprot id: A9C3R5
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

7955:si:ch211-137i24.10
gene id: 7955:si:ch211-137i24.10
uniprot id: A0A8M1NEQ5
uniprot id: A2BEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

7955:kcnj11
gene id: 7955:kcnj11
uniprot id: Q2HX26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

7955:anxa3b
gene id: 7955:anxa3b
uniprot id: A8E5E5
uniprot id: Q5U369
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

7955:ggt1a
gene id: 7955:ggt1a
uniprot id: A0A8M6YZQ0
uniprot id: Q7T2A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

7955:tmem87b
gene id: 7955:tmem87b
uniprot id: A0A8M9QNY0
names: Subcellular Location Annotation
messages: Membrane

7955:serinc2l
gene id: 7955:serinc2l
uniprot id: A0A8M3AIB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

7955:LOC101883670
gene id: 7955:LOC101883670
uniprot id: A0A8M9PZI0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:csgalnact1b
gene id: 7955:csgalnact1b
uniprot id: A0A8M2BE69
uniprot id: F1RD96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7955:zmp:0000000846
gene id: 7955:zmp:0000000846
uniprot id: A0A8M3AS32
uniprot id: A0A8M3AZ84
uniprot id: A0A8M3B253
uniprot id: A0A8M9PKQ8
uniprot id: A0A8M9PKR5
uniprot id: A0A8M9PY97
uniprot id: A0A8M9Q3W9
uniprot id: A0A8M9QEF6
uniprot id: E7EZJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:trpm1b
gene id: 7955:trpm1b
uniprot id: A0A8M9P6H0
uniprot id: A0A8M9PV08
uniprot id: A3KNP8
names: Subcellular Location Annotation
messages: Membrane

7955:slc18a1
gene id: 7955:slc18a1
uniprot id: A0A8M9QA73
names: Subcellular Location Annotation
messages: Membrane

7955:ankrd34a
gene id: 7955:ankrd34a
uniprot id: A0A8M2B4N9
names: Similarity
messages: Belongs to the ANKRD34 family.

7955:cecr6
gene id: 7955:cecr6
uniprot id: A0A8M2BBS3
uniprot id: E7F625
names: Similarity
messages: Belongs to the TMEM121 family.

7955:chrna4b
gene id: 7955:chrna4b
uniprot id: Q0PJT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:hsf4
gene id: 7955:hsf4
uniprot id: A0A8M3AJJ3
uniprot id: A0A8M9PQ64
uniprot id: Q5CZP2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the HSF family.
messages: Expression in the ocular lens starts at as early as 24 hours post fertilization (hpf).
messages: Heat-shock transcription factor that specifically binds heat shock promoter elements (HSE) (PubMed:22528049). Required for denucleation and organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light (PubMed:32061775, PubMed:33854238). In this process, may regulate denucleation of lens fiber cells in part by activating dnase1l1l and dnase2b transcription (PubMed:32061775). May be involved in DNA repair through the transcriptional regulation of rad51 (PubMed:22587838). May up-regulate TP53 protein in lens fiber cells, possibly through protein stabilization (PubMed:28981088). In the eye lens, controls the expression of alpha-crystallin B chain/CRYAB and consequently may be involved in the regulation of lysosomal acidification (PubMed:31786107).
messages: In knockout animals, the eye lens grows normally, but during lens differentiation, denucleation is impaired and the degradation of mitochondria and endoplasmic reticulum is suppressed.
messages: Nucleus
messages: Predominantly expressed in the eye.

7955:asip2b
gene id: 7955:asip2b
uniprot id: J3JQX9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:bnip1b
gene id: 7955:bnip1b
uniprot id: A0A0R4IG59
uniprot id: A0A8M1PRW9
names: Subcellular Location Annotation
messages: Membrane

7955:rnf43
gene id: 7955:rnf43
uniprot id: A0A8M9Q3W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

7955:pygma
gene id: 7955:pygma
uniprot id: Q503C7
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

7955:gng12a
gene id: 7955:gng12a
uniprot id: A0A8M3ANZ5
uniprot id: F8W3G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:guk1b
gene id: 7955:guk1b
uniprot id: A0A8M2BEA8
uniprot id: B8JJJ6
names: Similarity
messages: Belongs to the guanylate kinase family.

7955:unc5a
gene id: 7955:unc5a
uniprot id: A0A8M9PZC7
uniprot id: A0A8M9QB65
uniprot id: A0A8M9QGI2
uniprot id: A9JRY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

7955:plppr4a
gene id: 7955:plppr4a
uniprot id: A0A8M2BAD7
uniprot id: F1R7P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7955:nlk1
gene id: 7955:nlk1
uniprot id: Q6Q382
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

7955:cntnap1
gene id: 7955:cntnap1
uniprot id: A0A8N7TDM7
uniprot id: X1WGG7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

7955:zgc:66440
gene id: 7955:zgc:66440
uniprot id: A0A8M2B9F2
uniprot id: A0A8M3AVB3
uniprot id: A0A8M3B638
uniprot id: F1QUJ1
uniprot id: F1R959
uniprot id: Q4G0B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

7955:stim1b
gene id: 7955:stim1b
uniprot id: A0A0R4IAT9
uniprot id: A0A8M1P2M0
uniprot id: A0A8M2B879
uniprot id: A0A8M3AU34
uniprot id: F1R6G6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:cfap45
gene id: 7955:cfap45
uniprot id: A0A8M1NCB7
uniprot id: A2RV04
names: Similarity
messages: Belongs to the CFAP45 family.

7955:apex1
gene id: 7955:apex1
uniprot id: A0A0R4IWF9
uniprot id: A0A2R9YJQ0
uniprot id: A0A8M1P554
uniprot id: A0A8M1P9D9
uniprot id: A0A8M1PAH1
uniprot id: F1QTR9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

7955:slc37a2
gene id: 7955:slc37a2
uniprot id: A0A8M9Q311
uniprot id: A0A8M9QDN9
uniprot id: Q7SY29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Endoplasmic reticulum membrane
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction.
messages: Membrane

7955:stc2a
gene id: 7955:stc2a
uniprot id: Q5IRA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.
messages: Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.

7955:erap1b
gene id: 7955:erap1b
uniprot id: A0A8M1PE71
uniprot id: A0A8M3B9L5
uniprot id: F1QFR6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

7955:LOC100331068
gene id: 7955:LOC100331068
uniprot id: A0A8M9PZF2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:pafah1b1b
gene id: 7955:pafah1b1b
uniprot id: A0A8M9PQB6
uniprot id: Q803D2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, nde1 and ndel1.
messages: Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Enriched in the photoreceptor cell layer.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in the PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells.
messages: centrosome
messages: cytoskeleton

7955:wash1
gene id: 7955:wash1
uniprot id: A4IG59
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
messages: Belongs to the WASH1 family.
messages: Component of the WASH complex.
messages: Early endosome membrane
messages: Recycling endosome membrane
messages: The VCA (verprolin, cofilin, acidic) domain promotes actin polymerization by the Arp2/3 complex in vitro.

7955:LOC101882338
gene id: 7955:LOC101882338
uniprot id: A0A8M2BKQ9
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:cox4i1l
gene id: 7955:cox4i1l
uniprot id: F1R6I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

7955:tapt1b
gene id: 7955:tapt1b
uniprot id: A2BIE7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Expressed in the otic vesicle at 1 days post fertilization (dpf) (PubMed:26365339). Expressed in mesenchyme pectoral fins surrounding the cartilage of the endoskeletal disc, and in the epithelial cells of the oral cavity at 3 dpf (PubMed:26365339). Expressed weakly in the pronephric duct and the liver at 3 dpf (PubMed:26365339).
messages: Membrane
messages: Plays a role in primary cilia formation (PubMed:26365339). Involved in cartilage and bone development (PubMed:26365339). May play a role in the differentiation of cranial neural crest cells (PubMed:26365339). May act as a downstream effector of hoxc8 during development (By similarity).
messages: centrosome
messages: cilium basal body

7955:lim2.5
gene id: 7955:lim2.5
uniprot id: Q5BKW4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:itga8
gene id: 7955:itga8
uniprot id: A0A8M9PK29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:LOC110439963
gene id: 7955:LOC110439963
uniprot id: A0A8M9PQF0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:si:ch211-140m22.7
gene id: 7955:si:ch211-140m22.7
uniprot id: A0A2R8RW11
uniprot id: A0A8M1P3K6
uniprot id: A0A8M1P4K7
uniprot id: A0A8M3AVZ6
uniprot id: A0A8M3B2M1
uniprot id: A0A8M3B5K9
uniprot id: A0A8M3BCF4
uniprot id: A0A8M9PSB8
uniprot id: A0A8M9Q4P8
uniprot id: A0A8M9QAX5
uniprot id: A0A8M9QJT6
uniprot id: E7F2K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion inner membrane

7955:trmt10b
gene id: 7955:trmt10b
uniprot id: Q08BM0
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.
messages: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs.

7955:vdrb
gene id: 7955:vdrb
uniprot id: Q1L673
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Cytoplasm
messages: Detected in embryo 24 to 48 hours after fertilization, and in intestinal bulb.
messages: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding (By similarity). Interacts with ncoa1 and possibly other coactivators, leading to a strong increase of transcription of target genes (By similarity).
messages: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
messages: Nucleus
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

7955:rnf111
gene id: 7955:rnf111
uniprot id: A0A8M1QLM8
uniprot id: A0A8M2BG80
uniprot id: F1QWE1
uniprot id: N0A274
uniprot id: R4KWC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arkadia family.
messages: PML body

7955:LOC100148237
gene id: 7955:LOC100148237
uniprot id: A0A8M1QL23
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:pxmp2
gene id: 7955:pxmp2
uniprot id: Q66HU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

7955:crhbp
gene id: 7955:crhbp
uniprot id: Q6DG79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

7955:cyp21a2
gene id: 7955:cyp21a2
uniprot id: A0A8M9NZM6
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:lrrfip1a
gene id: 7955:lrrfip1a
uniprot id: A0A8M2BF13
uniprot id: A0A8M3BCG7
uniprot id: A0A8M9PA40
uniprot id: A0A8M9PA47
uniprot id: A0A8M9PLF4
uniprot id: A0A8M9PSJ5
uniprot id: A0A8M9PSK0
uniprot id: A0A8M9PSU5
uniprot id: A0A8M9PSV0
uniprot id: A0A8M9PZR4
uniprot id: A0A8M9PZR9
uniprot id: A0A8M9Q321
uniprot id: A0A8M9Q531
uniprot id: A0A8M9QBC1
uniprot id: A0A8M9QBD2
uniprot id: A0A8M9QBD6
uniprot id: A0A8M9QFZ3
uniprot id: A0A8M9QFZ6
uniprot id: A0A8M9QG03
uniprot id: A0A8M9QK54
uniprot id: A0A8M9QK63
uniprot id: A0A8M9QK65
names: Similarity
messages: Belongs to the LRRFIP family.

7955:si:ch211-207k7.4
gene id: 7955:si:ch211-207k7.4
uniprot id: A0A8M1NK32
uniprot id: B0V1J6
names: Similarity
messages: Belongs to the HscB family.

7955:cables2b
gene id: 7955:cables2b
uniprot id: A0A8M1QKI2
uniprot id: E7F0B6
names: Similarity
messages: Belongs to the cyclin family.

7955:cdk5rap1
gene id: 7955:cdk5rap1
uniprot id: A8WGJ0
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

7955:abcg4a
gene id: 7955:abcg4a
uniprot id: A2BFT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

7955:rpl7
gene id: 7955:rpl7
uniprot id: Q6Q417
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

7955:mib1
gene id: 7955:mib1
uniprot id: Q804S5
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intestine. Essential for early embryonic development.
messages: Interacts with deltaA (dla) and deltaD (dld).
messages: Mutants have a disorganized brain and neural tube, bent tail and very small or absent otoliths.
messages: The ANK repeats are involved in Delta receptor internalization.
messages: The N-terminal domain (1-440) mediates the interaction with Delta receptors.
messages: The RING fingers mediate the E3 ligase activity. The third RING finger probably plays a central role in this process. The role of the other RING fingers remains unclear.
messages: centriolar satellite

7955:slc35b2
gene id: 7955:slc35b2
uniprot id: Q6P101
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

7955:cdk2
gene id: 7955:cdk2
uniprot id: Q7ZWB1
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:antxr2a
gene id: 7955:antxr2a
uniprot id: A4QP34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

7955:ldhd
gene id: 7955:ldhd
uniprot id: F1QXM5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At 3 dpf, mutant embryos show no visible abnormalities compared to wild-type embryos. They do not display any ocular abnormalities at 5 dpf. They nevertheless exhibit elevated levels of D-lactate, but not L-lactate compared to wild-type larvae.
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Involved in D-lactate, but not L-lactate catabolic process.
messages: Mitochondrion

7955:gnrhr2
gene id: 7955:gnrhr2
uniprot id: B9P4N4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:marcksl1b
gene id: 7955:marcksl1b
uniprot id: Q6NWH2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MARCKS family.
messages: Cell membrane
messages: Detected from 24 to 72 hours post-fertilization (hpf).
messages: Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation.
messages: Morpholino knockdown of the protein results in reduced head and eye size, a ventrally curved body, and enlarged brain vesicles. In the craniofacial cartilage, the ceratobranchial arches are reduced. Formation of ceratohyal cartilage is disrupted with an abnormal angle relative to wild-type. Morphogenesis of the developing neural tube is abnormal, with a smaller angle between the walls of the hindbrain neuroepithelium at 24 hours post-fertilization (hpf) and in some cases a partial opening in the dorsal region. Some deformation of the midbrain walls is also found. Retinal development is significantly delayed; no retinal ganglion cells (RGCs) are detected at 30 hpf and reduced numbers are found at 60 hpf. RGCs also appear to be mislocalized. In about a third of embryos, three instead of two otoliths are detected in the inner ear. Cilium length in Kupffer's vesicle is significantly reduced. Cilia in the olfactory placode also appear to be fewer in number and have reduced length. Double morpholino knockdown of marcksl1a and marckls1b results in a more pronounced developmental delay in the retina. Double morpholino knockdown of marcksb and marcksl1b results in retinal morphogenesis defects of increased severity. The optic cup structure is not apparent, and very few atoh7-positive retinal ganglion cell precursors are detected. Double morpholino knockdown of marcksb and marcksl1b also results in more severe defects in neural tube morphology, with partial duplications of the neural tube in the hindbrain region.
messages: Strongly expressed in brain and eye. Also detected at lower levels in muscle.
messages: cytoskeleton

7955:zgc:194282
gene id: 7955:zgc:194282
uniprot id: A0A8M1NIX1
uniprot id: X1WHM4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:zgc:172075
gene id: 7955:zgc:172075
uniprot id: A0A8M9QDB9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:mettl16
gene id: 7955:mettl16
uniprot id: Q6DC64
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Cytoplasm
messages: Methyltransferase activity is autoinhibited by the K-loop region that blocks S-adenosyl-L-methionine-binding. Upon activation, K-loop changes conformation, allowing S-adenosyl-L-methionine-binding and subsequent methyltransferase activity. mRNA N6-adenosine-methyltransferase activity is inhibited by zinc.
messages: Nucleus
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A splicing and protein expression. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs.
messages: The K-loop region occludes the S-adenosyl-L-methionine-binding pocket. Upon activation, conformation of the K-loop changes, allowing S-adenosyl-L-methionine-binding.
messages: The VCR (vertebrate conserved) regions bind the first hairpin of MAT2A mRNAs. The VCR regions interact with the internal stem-loop within U6 snRNAs, inducing the conformational rearrangement of the A43-containing region of U6 snRNA, thereby modifying the RNA structure to become suitable for productive catalysis by the methyltransferase region.

7955:timeless
gene id: 7955:timeless
uniprot id: A0A8M1P001
uniprot id: A0A8M9PUP9
uniprot id: E7FGL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the timeless family.
messages: Nucleus

7955:epn3b
gene id: 7955:epn3b
uniprot id: A0A8N7UTI6
names: Similarity
messages: Belongs to the epsin family.

7955:slc35a4
gene id: 7955:slc35a4
uniprot id: A0A8M1P4A4
uniprot id: F1R3E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

7955:inhbaa
gene id: 7955:inhbaa
uniprot id: Q6NYZ8
uniprot id: Q8QGE3
names: Similarity
messages: Belongs to the TGF-beta family.

7955:fbn2a
gene id: 7955:fbn2a
uniprot id: A0A8M9Q6D2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:ano5a
gene id: 7955:ano5a
uniprot id: A0A8M3APA6
uniprot id: A0A8M9P700
uniprot id: A0A8M9PHI6
uniprot id: A0A8M9PZA0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:si:dkey-40c23.2
gene id: 7955:si:dkey-40c23.2
uniprot id: A0A8M1RM44
uniprot id: A0A8M3AXC4
uniprot id: A0A8M3B3S3
uniprot id: A0A8M6Z137
uniprot id: X1WG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

7955:ilf2
gene id: 7955:ilf2
uniprot id: Q6NZ06
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may function to regulate transcription of undefined genes (By similarity).
messages: Forms heterodimers with ILF3.
messages: Nucleus

7955:hoxb5a
gene id: 7955:hoxb5a
uniprot id: P09014
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: First detected at 12.5 hours post-fertilization, continuing through to adult stages. At the 10-somite stage, expressed in the paraxial mesoderm with an anterior expression at somite 1. At the 20-somite stage, expressed within the developing CNS with an anterior expression limit at the anterior-most region of somite 1.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:galnt1
gene id: 7955:galnt1
uniprot id: E7FDA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:spic
gene id: 7955:spic
uniprot id: Q66IC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:arhgap32b
gene id: 7955:arhgap32b
uniprot id: A0A8M3ALJ2
uniprot id: A0A8M3AM92
uniprot id: A0A8M3AWX3
uniprot id: A0A8M3B4R9
uniprot id: A0A8M9PUM5
uniprot id: E7F0G8
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

7955:kif3cb
gene id: 7955:kif3cb
uniprot id: A0A8M1N5C8
uniprot id: F1QW58
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:crtc1b
gene id: 7955:crtc1b
uniprot id: A0A0R4IMH2
uniprot id: A0A8M3AXF4
uniprot id: A0A8M9Q7G4
uniprot id: A0A8M9QHV8
uniprot id: A0A8M9QLT1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:prox2
gene id: 7955:prox2
uniprot id: B2BHT6
names: Subcellular Location Annotation
messages: Nucleus

7955:zgc:195075
gene id: 7955:zgc:195075
uniprot id: B3DIJ3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:ankrd54
gene id: 7955:ankrd54
uniprot id: Q6DGX3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Midbody
messages: Nucleus
messages: Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

7955:ruvbl2
gene id: 7955:ruvbl2
uniprot id: P83571
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Fishes display embryonic cardiac hyperplasia with increased cell number and size by 72 hours post-fertilization. Gut and gut-derived organs are incapable of growth and differentiation after this time. The mutation enhances ATPase activity, rendering it DNA-independent and causes aggregation of the protein into large complexes.
messages: Forms homohexameric rings (Probable). Can form a dodecamer with ruvbl1 made of two stacked hexameric rings (By similarity). Component of the chromatin-remodeling Ino80 complex (By similarity). Component of some MLL1/MLL complex (By similarity).
messages: Has double-stranded DNA-stimulated ATPase activity (PubMed:12464178). Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin (PubMed:12464178). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (By similarity). May act as a regulator of embryonic heart growth (PubMed:12464178).
messages: Nucleus
messages: Widely expressed in the embryo. After 60 hours post-fertilization there is increased expression in heart, liver, branchial arches, exocrine pancreas and intestine.

7955:kars
gene id: 7955:kars
uniprot id: A0A0R4IC11
uniprot id: A0A8M1P3X7
uniprot id: Q6DHE6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

7955:plrdgb
gene id: 7955:plrdgb
uniprot id: Q9I9N8
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

7955:cpsf3l
gene id: 7955:cpsf3l
uniprot id: A0A8M2BDS7
uniprot id: F1QEY5
uniprot id: Q503E1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Belongs to the multiprotein complex Integrator.
messages: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Mediates the snRNAs 3' cleavage.
messages: Nucleus
messages: The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.

7955:opn1mw1
gene id: 7955:opn1mw1
uniprot id: A0A0N9NXZ8
uniprot id: Q9W6A5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
messages: Retinal double cone accessory photoreceptor cell outer segments.
messages: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

7955:oip5
gene id: 7955:oip5
uniprot id: A0A8N7UZ97
uniprot id: B8A4N0
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

7955:pign
gene id: 7955:pign
uniprot id: A0A8M3B6M9
uniprot id: E7EXW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

7955:c17h14orf159
gene id: 7955:c17h14orf159
uniprot id: A0A0R4IQ88
uniprot id: A0A8M1QRC9
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

7955:zgc:56576
gene id: 7955:zgc:56576
uniprot id: A0A8M1PCQ0
uniprot id: F1QKI4
names: Similarity
messages: Belongs to the RTRAF family.

7955:bola1
gene id: 7955:bola1
uniprot id: Q6DEL5
names: Similarity
messages: Belongs to the BolA/IbaG family.

7955:rnd3a
gene id: 7955:rnd3a
uniprot id: Q6PC71
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

7955:si:ch73-199e17.1
gene id: 7955:si:ch73-199e17.1
uniprot id: A0A8M2BFG6
uniprot id: D1MCG5
uniprot id: E7EYT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

7955:myd88
gene id: 7955:myd88
uniprot id: B2GQ86
uniprot id: Q5XJ85
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
messages: Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response.
messages: Cytoplasm
messages: Expression is highest in adults. In the embryo, maternal transcript levels are reduced during blastula and gastrula stages. Expression increases during segmentation and later stages.
messages: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.

7955:med23
gene id: 7955:med23
uniprot id: A0A8M2B755
uniprot id: A0A8M2B7H3
uniprot id: A0A8M9PSM3
uniprot id: Q5RIW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 23 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:LOC569920
gene id: 7955:LOC569920
uniprot id: A0A8M9QGQ9
uniprot id: A0A8M9QKT0
names: Similarity
messages: Belongs to the ANKLE2 family.

7955:pi4k2b
gene id: 7955:pi4k2b
uniprot id: Q49GP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Cell membrane
messages: Contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: cytosol

7955:lifra
gene id: 7955:lifra
uniprot id: A0A0R4IE17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

7955:necap2
gene id: 7955:necap2
uniprot id: A0A8M1P218
uniprot id: F1RAQ5
uniprot id: Q6DBU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

7955:zgc:162941
gene id: 7955:zgc:162941
uniprot id: A3KP47
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

7955:nr1d2b
gene id: 7955:nr1d2b
uniprot id: A0A8M2B6I7
uniprot id: B2GQD8
uniprot id: Q6GMI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:arpc5la
gene id: 7955:arpc5la
uniprot id: Q6P0D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: cytoskeleton

7955:sigmar1
gene id: 7955:sigmar1
uniprot id: A0A8M3B632
uniprot id: Q7ZWG9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer (By similarity).
messages: Homotrimer.
messages: May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile.
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

7955:map2k1
gene id: 7955:map2k1
uniprot id: Q4V947
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:mmp30
gene id: 7955:mmp30
uniprot id: Q1RM69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Secreted

7955:wnt1
gene id: 7955:wnt1
uniprot id: A0A8M2B987
uniprot id: B3DI55
uniprot id: P24257
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: First detected at around 8 hours post-fertilization (hpf) within the prospective midbrain-hindbrain boundary (MHB). By 10 hpf, expressed in two stripes that converge at the dorsal midline. During somitogenesis, this expression domain extends to the prospective epiphysis and the dorsal midline of the hindbrain; unlike wnt10b, wnt1 is not detected in the prospective cerebellum. The hindbrain domain bifurcates along the midline to form two dorsolateral columns with transverse bands of up-regulation at rhombomere boundaries; these are refined into stripes which are maintained at least until at least 48 hpf. At 30 hpf, expressed in the epiphysis, the dorsal midline of the optic tectum, the anterior half of the MHB constriction and in the hindbrain walls. Not detected in adults.
messages: In the embryo, expressed in the developing central nervous system (CNS), with an expression pattern very similar to that of wnt10b. During somitogenesis, expressed strongly in hindbrain boundary and roof plate cells.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained via rfng-mediated modulation of Notch activity.
messages: Morpholino knockdown results in broadening of hindbrain boundary marker expression.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Palmitoleoylation is necessary for proper trafficking to cell surface (By similarity). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).
messages: Secreted
messages: extracellular matrix

7955:atp6v0e1
gene id: 7955:atp6v0e1
uniprot id: Q5XJC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

7955:acvrl1
gene id: 7955:acvrl1
uniprot id: A0A8M3B616
uniprot id: A0A8M9P4Z5
uniprot id: A0A8M9PKJ3
uniprot id: Q8JFB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:adrb2a
gene id: 7955:adrb2a
uniprot id: I7GPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:sh3yl1
gene id: 7955:sh3yl1
uniprot id: A0A8N7TF62
uniprot id: X1WFC4
names: Similarity
messages: Belongs to the SH3YL1 family.

7955:olfcg8
gene id: 7955:olfcg8
uniprot id: A0A8M3AKH6
uniprot id: A0A8M3B2Z8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:adra1ab
gene id: 7955:adra1ab
uniprot id: A0A8M9PTZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:si:dkey-49c17.3
gene id: 7955:si:dkey-49c17.3
uniprot id: A0A8M2B2E2
uniprot id: A0A8M2B321
uniprot id: A0A8N7T553
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

7955:si:dkey-285b23.3
gene id: 7955:si:dkey-285b23.3
uniprot id: A0A8M6YV16
names: Similarity
messages: Belongs to the NXPE family.

7955:mrrf
gene id: 7955:mrrf
uniprot id: Q6GMJ7
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

7955:tnnt2a
gene id: 7955:tnnt2a
uniprot id: A0A8M2B8P4
uniprot id: A0A8M9PWK7
uniprot id: F1R0K6
uniprot id: Q90Y46
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

7955:LOC100331077
gene id: 7955:LOC100331077
uniprot id: A0A8M1RS69
uniprot id: F1Q6J0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:LOC100537138
gene id: 7955:LOC100537138
uniprot id: A0A8M6YZM0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:map6a
gene id: 7955:map6a
uniprot id: A0A2R8Q3V4
uniprot id: A0A8M2BJW2
uniprot id: A0A8M3AWZ1
uniprot id: A0A8M3AX12
uniprot id: A0A8M3BD76
uniprot id: A0A8M9QH51
uniprot id: E7F624
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

7955:c3a.3
gene id: 7955:c3a.3
uniprot id: A0A8M1N7W7
uniprot id: A0A8M9PID4
uniprot id: F1QX13
names: Subcellular Location Annotation
messages: Secreted

7955:smpx
gene id: 7955:smpx
uniprot id: Q6GMK5
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

7955:mki67
gene id: 7955:mki67
uniprot id: A0A8M1NZY3
uniprot id: A0A8M6Z3I0
uniprot id: E7F3N4
names: Subcellular Location Annotation
messages: Nucleus

7955:rem1
gene id: 7955:rem1
uniprot id: Q7ZVA2
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

7955:si:ch211-264e16.1
gene id: 7955:si:ch211-264e16.1
uniprot id: A0A8M9P1A8
uniprot id: A0A8M9PAC8
names: Subcellular Location Annotation
messages: Membrane

7955:phtf2
gene id: 7955:phtf2
uniprot id: Q6DKF6
names: Subcellular Location Annotation
messages: Membrane

7955:tmtopsb
gene id: 7955:tmtopsb
uniprot id: A0A2R8Q4C0
uniprot id: A0A8M1P6Y6
uniprot id: A0A8N7XJ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

7955:si:dkey-35i13.1
gene id: 7955:si:dkey-35i13.1
uniprot id: A0A8M1PU80
uniprot id: X1WF05
names: Subcellular Location Annotation
messages: Membrane

7955:si:dkey-261m9.18
gene id: 7955:si:dkey-261m9.18
uniprot id: Q561S9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:spsb3a
gene id: 7955:spsb3a
uniprot id: B1H1G8
names: Function
names: Similarity
messages: Belongs to the SPSB family.
messages: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

7955:sult1st3
gene id: 7955:sult1st3
uniprot id: Q6DHG7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:fam234b
gene id: 7955:fam234b
uniprot id: A0A8M2BIW2
names: Similarity
messages: Belongs to the FAM234 family.

7955:glg1a
gene id: 7955:glg1a
uniprot id: A0A8M1PU45
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Golgi outpost
messages: Membrane
messages: microtubule organizing center

7955:itm2cb
gene id: 7955:itm2cb
uniprot id: A0A8M9QGD2
uniprot id: Q7SYK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

7955:tmem59l
gene id: 7955:tmem59l
uniprot id: A8WG81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:best2
gene id: 7955:best2
uniprot id: A0A8N7TBM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

7955:isca1
gene id: 7955:isca1
uniprot id: Q4QRC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
messages: Mitochondrion

7955:gpc5c
gene id: 7955:gpc5c
uniprot id: A0A8M2BIS2
uniprot id: A0A8M2BIT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

7955:raraa
gene id: 7955:raraa
uniprot id: Q90271
uniprot id: T2DKU4
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: By retinoic acid in embryos.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.
messages: In the embryo, zygotic expression largely overlaps that of rarab, with high levels in hindbrain, lateral mesoderm and tail bud. In the adult, strong expression in brain and muscle, weaker expression in ovary, liver and digestive tract.
messages: Not expressed maternally. First detected at 8 hours post-fertilization (hpf) during gastrulation, with expression being restricted to the posterior epiblast. Expression then increases, reaching a peak at 24 hpf and decreasing from 30-48 hpf. At 9 hpf, expressed throughout the dorsal epiblast except at the dorsal midline, and ventrally in prospective tail and head regions. At 10-11 hpf, expressed in presumptive hindbrain, posterior neural plate, lateral mesoderm and tail bud. At 12 hpf, strongly expressed in the neural epithelium and tail bud and expressed at low levels elsewhere including the eye. At 24 hpf, restricted to the hindbrain with an anterior border at rhombomere 6-7, to anterior spinal cord and to head mesenchyme just posterior to the otic vesicle. At 48 hpf, hindbrain expression remains and there is diffuse expression in non-neural tissue in the pharyngeal region.
messages: Nucleus
messages: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning.
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

7955:ifnphi3
gene id: 7955:ifnphi3
uniprot id: A8E6E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

7955:dlc
gene id: 7955:dlc
uniprot id: A4JYS0
uniprot id: Q9IAT6
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.
messages: Strongly expressed in the early retina, where it precedes other delta proteins. Also expressed in cranial ganglia, in sensory epithelia including ear and lateral line and in scattered epidermal cells. In the mesoderm, expression is visible by 50% epiboly; it is expressed subsequently in the tail bud, in stripes in the presomitic mesoderm and in the posterior half of each somite. Also expressed in notochord, blood vessels and pronephros. In contrast to other delta proteins, it is not expressed in the majority of nascent primary neurons. In somites, it marks the posterior part of each formed somite, while deltaD (dld) marks the anterior part.
messages: Ubiquitinated by mib, leading to its endocytosis and subsequent degradation.

7955:kcnd2
gene id: 7955:kcnd2
uniprot id: A0A8M3B1N2
uniprot id: Q5VSI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

7955:rdh8a
gene id: 7955:rdh8a
uniprot id: A0A8M9PV58
uniprot id: Q6PC70
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:ptchd4
gene id: 7955:ptchd4
uniprot id: Q5RIV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Cell membrane

7955:nmbr
gene id: 7955:nmbr
uniprot id: A0A8N7UR00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:tspan9b
gene id: 7955:tspan9b
uniprot id: Q6GMK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:sobpa
gene id: 7955:sobpa
uniprot id: A5X7A0
names: Function
names: Similarity
messages: Belongs to the SOBP family.
messages: Implicated in development of the cochlea.

7955:rgmd
gene id: 7955:rgmd
uniprot id: A0A8M9P478
uniprot id: Q7SYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

7955:fgf20b
gene id: 7955:fgf20b
uniprot id: Q2LJ24
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7955:wdr18
gene id: 7955:wdr18
uniprot id: B2GT94
uniprot id: Q68EI0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the left-right asymmetry of internal organs, but not their specification.
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles.
messages: Dynein axonemal particle
messages: Expressed from the 1-4 cell stage and in DFCs at 75%-epiboly stage. By the 6-somite stage, its expression in the Kupffer's vesicle is detectable in addition to some basal expression levels in other cells. Later at the 18-somite stage, detected ubiquitously throughout the embryo. After 2 dpf (days post fertilization), expressed in endodermal organs, including the pancreas and liver.
messages: Involved in left-right determination through controlling the correct clustering and migration of dorsal forerunner cells (DFCs) and Kupffer's vesicle formation (PubMed:21876750). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity).
messages: nucleolus
messages: nucleoplasm

7955:si:ch73-390b10.2
gene id: 7955:si:ch73-390b10.2
uniprot id: E7FB29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

7955:si:ch73-195i19.3
gene id: 7955:si:ch73-195i19.3
uniprot id: A0A8M9PYN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:si:ch211-185a18.2
gene id: 7955:si:ch211-185a18.2
uniprot id: H6D7E6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALPID3 family.
messages: Homozygous for these mutant alleles complete embryogenesis normally, but manifest a cystic kidney phenotype during the early larval stages and die within a month of hatching. Elimination of maternally derived talpid3 activity by germline replacement resulted in embryonic lethality of talpid3 homozygotes. The phenotype of such maternal and zygotic mutant show absence of primary and motile cilia as well as aberrant Hedgehog signaling.
messages: Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: Ubiquitously distributed in embryos from early cleavage stages through to 2 dpf.
messages: centriole
messages: cilium basal body

7955:palm1a
gene id: 7955:palm1a
uniprot id: A0A8M2B2L5
uniprot id: A0A8M2B2U8
uniprot id: A0A8M9PUW4
uniprot id: E9QIM7
uniprot id: Q568R7
names: Similarity
messages: Belongs to the paralemmin family.

7955:foxd3
gene id: 7955:foxd3
uniprot id: A0A8M1PBR1
uniprot id: F1R5S7
names: Subcellular Location Annotation
messages: Nucleus

7955:htr5aa
gene id: 7955:htr5aa
uniprot id: A0A0R4IFY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:LOC103909001
gene id: 7955:LOC103909001
uniprot id: A0A8M9P0U5
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

7955:spry1
gene id: 7955:spry1
uniprot id: B1PBZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

7955:taar20l
gene id: 7955:taar20l
uniprot id: A0A8M3AX69
uniprot id: F1RB61
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:zgc:66024
gene id: 7955:zgc:66024
uniprot id: F1RD68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

7955:exoc3l4
gene id: 7955:exoc3l4
uniprot id: A0A8M1NSX5
uniprot id: B8JJU3
names: Similarity
messages: Belongs to the SEC6 family.

7955:si:ch73-74h11.1
gene id: 7955:si:ch73-74h11.1
uniprot id: A0A8M6YUE0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

7955:phgdh
gene id: 7955:phgdh
uniprot id: A0A8M1PFH7
uniprot id: F1QEY8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

7955:emc1
gene id: 7955:emc1
uniprot id: A0A8M2B912
uniprot id: A0A8N7TE71
uniprot id: E9QG66
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:ptmaa
gene id: 7955:ptmaa
uniprot id: Q6NV32
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At the 20-somite stage (18 hpf), expressed on the dorsal side of the embryo in the developing central and peripheral nervous system (CNS and PNS), in the tail bud and the pronephric ducts. In the PNS, expressed in the otic vesicle, trigeminal ganglion and the anterior lateral line placode. Localized throughout the hindbrain, with highest expression in rhombomeres 3 and 4. In the head, expressed in the olfactory placode and in the diencephalic region. At the end of the segmentation period (20 hpf), expression begins in the newly forming endodermal pouches, and weakly in the pharyngeal arch precursor cells. During the early pharyngula period, expressed in the pectoral fin bud, the developing retina, and still present in the central nervous system and endodermal pouches. In the tail, expressed in the spinal cord and posterior lateral line precursors. Weakly expressed in the pronephric ducts, only in the corpuscles of Stanius. At 48 hpf, still expressed in the retina and brain, where expression is almost uniform. At this stage, expression is decreased in the spinal cord and is absent from the lateral line cells and pronephric ducts, but appears in the intestine and continues in the pharyngeal arches. In 72 hpf embryos, expression in the brain remains uniform but is restricted to amacrine cells in the retina. In the pharyngeal arches, expression continues to be limited to the ectodermal and endodermal covering cells.
messages: Belongs to the pro/parathymosin family.
messages: Expression begins at 16 hpf and gradually increases up to 72 hpf.
messages: Nucleus

7955:LOC108180125
gene id: 7955:LOC108180125
uniprot id: A0A8M9P2D7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:rnf34a
gene id: 7955:rnf34a
uniprot id: A0A8M2BK99
uniprot id: Q4V919
names: Subcellular Location Annotation
messages: Cell membrane

7955:cntnap5b
gene id: 7955:cntnap5b
uniprot id: A0A8M3AM72
uniprot id: A0A8M3AUM4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:pck1
gene id: 7955:pck1
uniprot id: A0A8M9PZI9
uniprot id: Q7T3G9
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

7955:cct6a
gene id: 7955:cct6a
uniprot id: Q7ZYX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

7955:cacna2d3
gene id: 7955:cacna2d3
uniprot id: A0A8M1RM50
uniprot id: A0A8M2BK51
uniprot id: A0A8M2BK91
uniprot id: A0A8M6Z1U2
uniprot id: F1R3X8
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

7955:unm sa911
gene id: 7955:unm_sa911
uniprot id: A0A8M9P9Q7
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:aste1
gene id: 7955:aste1
uniprot id: Q1LYL8
names: Function
names: Similarity
messages: Belongs to the asteroid family.
messages: Possible role in EGF receptor signaling.

7955:si:dkey-108k21.11
gene id: 7955:si:dkey-108k21.11
uniprot id: A0A8M1RLA9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:greb1l
gene id: 7955:greb1l
uniprot id: A0A8M9NZP6
uniprot id: B8JKP6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Expressed in the mesoderm, including the intermediate mesoderm, the origin of the pronephros, at 90% epiboly (8.5 hpf) and early somitogenesis stages (11.5 hpf).
messages: Membrane
messages: Morpholino knockdown of the protein causes abnormal morphology of the proximal kidney.
messages: Plays a major role in early metanephros development.

7955:gpat3
gene id: 7955:gpat3
uniprot id: A0A8M9PTT1
uniprot id: B2GTF5
uniprot id: Q6DG38
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Protects cells against lipotoxicity.
messages: Endoplasmic reticulum membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

7955:cacna1e
gene id: 7955:cacna1e
uniprot id: A0A8M6YZX9
uniprot id: A0A8M6Z7T0
uniprot id: A0A8M6Z865
uniprot id: A0A8M9PR96
uniprot id: A0A8M9Q3S8
uniprot id: A0A8M9QE19
uniprot id: A0A8M9QIU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane

7955:LOC100536708
gene id: 7955:LOC100536708
uniprot id: A0A8M1RIG7
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7955:zmp:0000001138
gene id: 7955:zmp:0000001138
uniprot id: A4JYR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

7955:umodl1
gene id: 7955:umodl1
uniprot id: A0A8N7UW14
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:porcnl
gene id: 7955:porcnl
uniprot id: Q803X3
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:152791
gene id: 7955:zgc:152791
uniprot id: F6NVZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

7955:si:ch211-225p5.8
gene id: 7955:si:ch211-225p5.8
uniprot id: A8E7Q8
uniprot id: A9JRB7
names: Subcellular Location Annotation
messages: Membrane

7955:calr
gene id: 7955:calr
uniprot id: A0A8M1PFS2
uniprot id: F1Q8W8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen
messages: Monomer.

7955:cdk11b
gene id: 7955:cdk11b
uniprot id: A0A8M3AVM5
uniprot id: A0A8M3BC62
uniprot id: Q5PRD1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

7955:or128-1
gene id: 7955:or128-1
uniprot id: Q2PRG4
names: Subcellular Location Annotation
messages: Membrane

7955:ctgfb
gene id: 7955:ctgfb
uniprot id: A5PN60
uniprot id: A6XA79
uniprot id: C9ELM6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:snrpd3
gene id: 7955:snrpd3
uniprot id: A0A8M9PQT7
uniprot id: Q6IQ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

7955:si:ch211-156l18.7
gene id: 7955:si:ch211-156l18.7
uniprot id: A0A8N7UQN1
names: Similarity
messages: Belongs to the intermediate filament family.

7955:LOC566927
gene id: 7955:LOC566927
uniprot id: A0A2R8QG20
uniprot id: A0A8M6Z105
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ctnnbip1
gene id: 7955:ctnnbip1
uniprot id: Q9I903
names: Similarity
messages: Belongs to the CTNNBIP1 family.

7955:hsp90ab1
gene id: 7955:hsp90ab1
uniprot id: O57521
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the heat shock protein 90 family.
messages: By heat shock during early embryogenesis.
messages: Cytoplasm
messages: Detected throughout the embryo and in low levels in the musculature. Expressed predominantly in the developing brain, tail bud and cells surrounding the posterior margin of the yolk tube.
messages: Dynein axonemal particle
messages: Expressed throughout embryonic development.
messages: In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
messages: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (By similarity). Not required for myofibril formation in skeletal muscles (PubMed:10364427, PubMed:17586488).
messages: Monomer. Homodimer (By similarity). Interacts with unc45b (PubMed:17586488).
messages: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.

7955:gba3
gene id: 7955:gba3
uniprot id: Q502A1
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

7955:kpna2
gene id: 7955:kpna2
uniprot id: Q6DI01
names: Similarity
messages: Belongs to the importin alpha family.

7955:LOC101886447
gene id: 7955:LOC101886447
uniprot id: A0A8M6YWJ3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

7955:polr1e
gene id: 7955:polr1e
uniprot id: Q501W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

7955:cacng5b
gene id: 7955:cacng5b
uniprot id: X1WEB1
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

7955:hoxc1a
gene id: 7955:hoxc1a
uniprot id: B3DHA1
uniprot id: Q98SH9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed both maternally and zygotically, from ova through to 48 hours post-fertilization.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:pkd1l3
gene id: 7955:pkd1l3
uniprot id: A0A8M9QI22
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ptgr2
gene id: 7955:ptgr2
uniprot id: A0A8M1P4D1
uniprot id: Q6DEI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer.

7955:prkdc
gene id: 7955:prkdc
uniprot id: A0A8M3B1E3
uniprot id: E7F4J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: nucleolus

7955:LOC110439798
gene id: 7955:LOC110439798
uniprot id: A0A8M9PY82
uniprot id: A0A8M9Q951
uniprot id: A0A8M9QEE9
names: Subcellular Location Annotation
messages: Nucleus

7955:phkg2
gene id: 7955:phkg2
uniprot id: A0A8M3AY76
uniprot id: F1QXS6
uniprot id: Q7ZYW8
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

7955:plekho1b
gene id: 7955:plekho1b
uniprot id: A0A8M1P2S9
uniprot id: E9QIX7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:st6gal2b
gene id: 7955:st6gal2b
uniprot id: D2U4T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:neto1l
gene id: 7955:neto1l
uniprot id: A0A8M9PGC0
uniprot id: A0A8M9PM78
uniprot id: E7F4T5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tob1b
gene id: 7955:tob1b
uniprot id: Q7SZP8
names: Similarity
messages: Belongs to the BTG family.

7955:nos2b
gene id: 7955:nos2b
uniprot id: A0A8M2B421
uniprot id: A0A8M3AHD3
uniprot id: A0A8M6Z0P3
uniprot id: A9JNR5
uniprot id: F1QML0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

7955:si:ch211-117m20.4
gene id: 7955:si:ch211-117m20.4
uniprot id: A0A8N7T7W8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ilk
gene id: 7955:ilk
uniprot id: Q6PHD6
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

7955:zgc:136892
gene id: 7955:zgc:136892
uniprot id: Q1RLR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:or110-1
gene id: 7955:or110-1
uniprot id: F1QJ45
uniprot id: Q2PRK5
names: Subcellular Location Annotation
messages: Membrane

7955:zgc:112356
gene id: 7955:zgc:112356
uniprot id: Q4V9H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

7955:acsl1b
gene id: 7955:acsl1b
uniprot id: F1QDA6
uniprot id: Q6DEJ3
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

7955:LOC110440162
gene id: 7955:LOC110440162
uniprot id: A0A8M9QN66
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:fam163b
gene id: 7955:fam163b
uniprot id: E9QH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

7955:gcn1
gene id: 7955:gcn1
uniprot id: A0A8M3BBK0
names: Similarity
messages: Belongs to the GCN1 family.

7955:timm17a
gene id: 7955:timm17a
uniprot id: Q6NZZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

7955:zgc:173587
gene id: 7955:zgc:173587
uniprot id: A7MCA8
names: Similarity
messages: Belongs to the histone H2B family.

7955:ccnb1
gene id: 7955:ccnb1
uniprot id: Q9IB44
names: Similarity
messages: Belongs to the cyclin family.

7955:fam26f
gene id: 7955:fam26f
uniprot id: A0PJS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

7955:pald1a
gene id: 7955:pald1a
uniprot id: Q803E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paladin family.
messages: cytosol

7955:crygs3
gene id: 7955:crygs3
uniprot id: Q5XTN7
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:LOC560917
gene id: 7955:LOC560917
uniprot id: A0A8M9QCV4
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:ezrb
gene id: 7955:ezrb
uniprot id: Q5TZG5
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:tmlhe
gene id: 7955:tmlhe
uniprot id: A0A8N7T528
uniprot id: E7F0M9
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

7955:ptpn2b
gene id: 7955:ptpn2b
uniprot id: B2GNN9
uniprot id: Q803R3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

7955:cacna1db
gene id: 7955:cacna1db
uniprot id: A0A8M9QJ57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

7955:slc31a2
gene id: 7955:slc31a2
uniprot id: A0A8M1NW97
uniprot id: A0A8M3AM17
uniprot id: A0A8M3B4K8
uniprot id: E9QC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

7955:dia1a
gene id: 7955:dia1a
uniprot id: Q5U3S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

7955:bzw1a
gene id: 7955:bzw1a
uniprot id: Q6PD83
names: Function
names: Similarity
messages: Belongs to the BZW family.
messages: Translation initiation regulator which may repress repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity).

7955:ccnt2a
gene id: 7955:ccnt2a
uniprot id: A0A2R8QAB1
uniprot id: A0A8M1NUM2
uniprot id: Q803Q8
names: Similarity
messages: Belongs to the cyclin family.

7955:paqr5a
gene id: 7955:paqr5a
uniprot id: Q7ZVH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane
messages: Steroid membrane receptor. Binds progesterone. May be involved in oocyte maturation (By similarity).

7955:elavl2
gene id: 7955:elavl2
uniprot id: A0A2R8S0A2
uniprot id: A0A8M1N038
uniprot id: Q6GQM6
names: Similarity
messages: Belongs to the RRM elav family.

7955:nf2b
gene id: 7955:nf2b
uniprot id: Q6Q413
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

7955:eif4a3
gene id: 7955:eif4a3
uniprot id: B2GTC1
uniprot id: Q7ZVA6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity). Involved in craniofacial development (PubMed:24360810).
messages: Belongs to the DEAD box helicase family.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains casc3, eif4a3, magoh and rbm8a.
messages: Morpholino EIF4A3 knockdown results in multiple defects in craniofacial structures. Fish morphants staged at 24 hpf show eyes reduced in size, and dark and opaque zones in all brain structures. In addition, the otic vesicle and the midbrain/hindbrain border regions are barely detectable. Cartilage and bone staining reveals underdevelopment of craniofacial cartilage, bone alterations, and clefting of the lower jaw. The third through sixth pharyngeal arches are underdeveloped in morphants.
messages: Nucleus
messages: Nucleus speckle

7955:sst5
gene id: 7955:sst5
uniprot id: A0A8M9PRQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted
messages: Somatostatin inhibits the release of somatotropin.

7955:tspo
gene id: 7955:tspo
uniprot id: Q5XJB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

7955:cep44
gene id: 7955:cep44
uniprot id: A0A8M1NBH8
uniprot id: A0A8M9PJ84
uniprot id: A0A8M9PWN9
uniprot id: F6NJX7
names: Subcellular Location Annotation
messages: Midbody
messages: centriole
messages: spindle pole

7955:b3galt2
gene id: 7955:b3galt2
uniprot id: Q6NYS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:cx52.9
gene id: 7955:cx52.9
uniprot id: Q6NYU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:si:dkey-112m2.1
gene id: 7955:si:dkey-112m2.1
uniprot id: A0A8M3AM71
uniprot id: X1WHI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

7955:aplnr2
gene id: 7955:aplnr2
uniprot id: F1QJG4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:susd6
gene id: 7955:susd6
uniprot id: A0A8M1N915
uniprot id: A0A8M2B7I3
uniprot id: A0A8M2B7I4
uniprot id: U3JAN2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:bcl2b
gene id: 7955:bcl2b
uniprot id: A0A8M1Q7L4
uniprot id: F8W266
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

7955:smtla
gene id: 7955:smtla
uniprot id: A0A8M9PFJ9
uniprot id: Q330L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

7955:prph2b
gene id: 7955:prph2b
uniprot id: Q6PBN3
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

7955:si:ch211-173a9.7
gene id: 7955:si:ch211-173a9.7
uniprot id: A0A8M9PF31
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC101882681
gene id: 7955:LOC101882681
uniprot id: A0A8M9Q7W6
uniprot id: A0A8M9QDT8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pfkla
gene id: 7955:pfkla
uniprot id: A0A8N7TBX7
uniprot id: E7F9M6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:avpr1ab
gene id: 7955:avpr1ab
uniprot id: A0A059WNC2
uniprot id: F1Q5N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:hoxa11a
gene id: 7955:hoxa11a
uniprot id: B3DK23
uniprot id: Q9DDU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:b4galt6
gene id: 7955:b4galt6
uniprot id: A0A8M2BHG8
uniprot id: Q802Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

7955:admp
gene id: 7955:admp
uniprot id: Q8UVQ2
names: Similarity
messages: Belongs to the TGF-beta family.

7955:crsp7
gene id: 7955:crsp7
uniprot id: Q90YL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 26 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:tpst1l
gene id: 7955:tpst1l
uniprot id: Q7ZT02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

7955:sdhc
gene id: 7955:sdhc
uniprot id: B0S5Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

7955:LOC100331381
gene id: 7955:LOC100331381
uniprot id: A0A8M6YU34
uniprot id: A0A8M9PNY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:p2rx5
gene id: 7955:p2rx5
uniprot id: B0R182
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

7955:ednraa
gene id: 7955:ednraa
uniprot id: B3DLG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

7955:mmp17b
gene id: 7955:mmp17b
uniprot id: A0A0R4IB00
uniprot id: A0A8M1RRF6
uniprot id: A0A8M9PZY9
names: Similarity
messages: Belongs to the peptidase M10A family.

7955:map7d2b
gene id: 7955:map7d2b
uniprot id: A0A8M9P648
uniprot id: A0A8M9PGE0
uniprot id: A0A8M9PMA2
names: Similarity
messages: Belongs to the MAP7 family.

7955:mical2b
gene id: 7955:mical2b
uniprot id: A0A8M9P6G8
uniprot id: A0A8M9PGW2
uniprot id: A0A8M9PMS9
uniprot id: A0A8M9PMT4
uniprot id: A0A8M9PV03
uniprot id: A0A8M9PYF5
uniprot id: A0A8M9PYG2
uniprot id: F1RA39
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm
messages: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrtf-a presence in the nucleus and promote srf:mkl1/mrtf-a-dependent gene transcription (PubMed:24440334).
messages: Nucleus
messages: Small hearts that fail to undergo normal looping at 24 hours post-fertilization (hpf) with thin, linear morphology compared to wild-type hearts at 48 hpf. moreover, cardiomyocytes hearts are spatially disorganized. Defects in srf:mkl1/mrtf-a-dependent gene transcription.

7955:si:ch211-137a8.2
gene id: 7955:si:ch211-137a8.2
uniprot id: A0A8M3B132
uniprot id: F1Q5Y7
names: Similarity
messages: Belongs to the nesprin family.

7955:dnase2b
gene id: 7955:dnase2b
uniprot id: A0A8M3B6R6
uniprot id: A0A8N7UVV8
uniprot id: F1QKH7
names: Similarity
messages: Belongs to the DNase II family.

7955:LOC558044
gene id: 7955:LOC558044
uniprot id: A0A8M1NF56
uniprot id: A0A8M2BCL2
uniprot id: A0A8M2BCP3
uniprot id: A0A8M9PK72
uniprot id: A0A8M9PXP3
uniprot id: F1QXB0
names: Similarity
messages: Belongs to the spectrin family.

7955:LOC100536657
gene id: 7955:LOC100536657
uniprot id: A0A8M2BIB9
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:agpat4
gene id: 7955:agpat4
uniprot id: Q6PGY2
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

7955:acat2
gene id: 7955:acat2
uniprot id: A0A8M9PSH6
uniprot id: Q7ZU18
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

7955:si:dkey-222b8.1
gene id: 7955:si:dkey-222b8.1
uniprot id: A0A8M1N9U9
uniprot id: A0A8M3AK78
uniprot id: Q1L8R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

7955:ppp2r5ea
gene id: 7955:ppp2r5ea
uniprot id: Q8AXX6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

7955:myo7aa
gene id: 7955:myo7aa
uniprot id: A0A8M9P9W0
uniprot id: Q9DGG9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:LOC110437879
gene id: 7955:LOC110437879
uniprot id: A0A8M9Q7B4
uniprot id: A0A8M9Q7B7
uniprot id: A0A8M9QGH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus

7955:ppef2a
gene id: 7955:ppef2a
uniprot id: A0A8M3ASP8
uniprot id: A0A8M3B9X2
uniprot id: A0A8M6YZE0
uniprot id: A0A8M9Q9R9
names: Similarity
messages: Belongs to the PPP phosphatase family.

7955:LOC100333270
gene id: 7955:LOC100333270
uniprot id: A0A8M1RL62
uniprot id: E7F9I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:ahr1a
gene id: 7955:ahr1a
uniprot id: A0A8M9NZ29
uniprot id: A0A8N7UZF6
uniprot id: Q8QGQ3
names: Subcellular Location Annotation
messages: Cytoplasm

7955:pknox1.2
gene id: 7955:pknox1.2
uniprot id: A0A8N7TEV4
uniprot id: E7FBG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

7955:manba
gene id: 7955:manba
uniprot id: Q7ZVY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Homodimer.
messages: Lysosome
messages: Monomer.
messages: Secreted

7955:olfm1b
gene id: 7955:olfm1b
uniprot id: A0A8M1P3V0
uniprot id: A0A8M1PAA0
uniprot id: B7ZD15
uniprot id: B7ZD17
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

7955:zgc:171713
gene id: 7955:zgc:171713
uniprot id: A0A8M3BE33
uniprot id: A7E2K0
uniprot id: B0QZZ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:or111-9
gene id: 7955:or111-9
uniprot id: A0A8M3AHF2
uniprot id: Q9I8Z1
names: Subcellular Location Annotation
messages: Membrane

7955:emc4
gene id: 7955:emc4
uniprot id: Q6P011
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

7955:ca10b
gene id: 7955:ca10b
uniprot id: A0A8M2BBM0
uniprot id: E7EYF2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

7955:cyb5r2
gene id: 7955:cyb5r2
uniprot id: Q0P487
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Membrane
messages: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis and drug metabolism.

7955:LOC101885844
gene id: 7955:LOC101885844
uniprot id: A0A8M3ATW4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:igfbp5b
gene id: 7955:igfbp5b
uniprot id: A0A8M1NJJ8
uniprot id: B0S525
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:srxn1
gene id: 7955:srxn1
uniprot id: A0A8M1RKC7
uniprot id: E7FBQ8
names: Similarity
messages: Belongs to the sulfiredoxin family.

7955:hhipl1
gene id: 7955:hhipl1
uniprot id: A0A8M1P8G5
uniprot id: A0A8M9PE11
uniprot id: A4IG31
uniprot id: F6PEI8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:soul2
gene id: 7955:soul2
uniprot id: F2XG12
names: Similarity
messages: Belongs to the HEBP family.

7955:mogat2
gene id: 7955:mogat2
uniprot id: A0A8M1N2V8
uniprot id: A0A8M1P3L0
uniprot id: F1QSW7
uniprot id: F1R0E7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:eif6
gene id: 7955:eif6
uniprot id: Q6ZM19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: nucleolus

7955:megf6a
gene id: 7955:megf6a
uniprot id: A0A8M3AYG1
uniprot id: A0A8M6Z4L7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:bola3
gene id: 7955:bola3
uniprot id: Q6DC87
names: Similarity
messages: Belongs to the BolA/IbaG family.

7955:suclg2
gene id: 7955:suclg2
uniprot id: A0A8M9QHZ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

7955:mettl2a
gene id: 7955:mettl2a
uniprot id: A8KBL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. METL family.
messages: Cytoplasm
messages: Monomer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by mettl2a requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite.

7955:arl13b
gene id: 7955:arl13b
uniprot id: Q8JHI3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex Required during embryogenesis for cilia formation in multiple organs such as the pronephric duct.
messages: Cilium-specific.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Detected at the 4- to 32-cell stage, suggesting it is expressed maternally.
messages: Embryos have a ventrally curved tail, ciliary defects and cystic kidneys.
messages: Interacts with EXOC2; regulates ARL13B localization to the cilium membrane.
messages: cilium membrane

7955:cyp17a2
gene id: 7955:cyp17a2
uniprot id: A7U483
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:zgc:172065
gene id: 7955:zgc:172065
uniprot id: A0A8M2BE33
uniprot id: A9JRB5
uniprot id: F1QNL4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:camk1gb
gene id: 7955:camk1gb
uniprot id: A0A8M2BLE1
uniprot id: A0A8M2BLR7
uniprot id: A0A8M9PSZ5
uniprot id: F1QB46
uniprot id: Q6P965
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:crygm2a
gene id: 7955:crygm2a
uniprot id: B3DIK4
uniprot id: Q4ZHG3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:aqp12
gene id: 7955:aqp12
uniprot id: Q0IIQ6
uniprot id: Q6DGW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

7955:uba3
gene id: 7955:uba3
uniprot id: A0A8M2B283
uniprot id: B2GSP4
uniprot id: Q7ZVX6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Arg-210 acts as a selectivity gate, preventing misactivation of ubiquitin by this NEDD8-specific E1 complex.
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.
messages: Catalytic subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity).
messages: Heterodimer of uba3 and nae1. Interacts with nedd8, ube2f and ube2m (By similarity).

7955:stam2
gene id: 7955:stam2
uniprot id: A0A8M1N302
uniprot id: A8WI00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane

7955:smpd2a
gene id: 7955:smpd2a
uniprot id: F1QUD7
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

7955:zgc:158291
gene id: 7955:zgc:158291
uniprot id: A1A5W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

7955:ppp3r1a
gene id: 7955:ppp3r1a
uniprot id: A0A0K0WSQ5
uniprot id: A0A8M3BEF6
uniprot id: E9QG20
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

7955:rnf2
gene id: 7955:rnf2
uniprot id: A0A0H2UKC6
uniprot id: A0A8M1PAV1
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

7955:ildr1a
gene id: 7955:ildr1a
uniprot id: Q7T2Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

7955:fzd7a
gene id: 7955:fzd7a
uniprot id: Q6NV44
uniprot id: Q90ZT3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:zgc:171446
gene id: 7955:zgc:171446
uniprot id: A8WFS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:hbba2
gene id: 7955:hbba2
uniprot id: Q6ZM12
names: Similarity
messages: Belongs to the globin family.

7955:selp
gene id: 7955:selp
uniprot id: E5DV48
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ypel2a
gene id: 7955:ypel2a
uniprot id: E9QDC9
names: Similarity
messages: Belongs to the yippee family.

7955:tnfsf12
gene id: 7955:tnfsf12
uniprot id: A8KBV2
uniprot id: Q08BZ0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:LOC799265
gene id: 7955:LOC799265
uniprot id: A0A8M1Q7G5
uniprot id: E7EXH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

7955:fam219b
gene id: 7955:fam219b
uniprot id: A0A2R8Q6A6
uniprot id: Q58EI9
names: Similarity
messages: Belongs to the FAM219 family.

7955:oc90
gene id: 7955:oc90
uniprot id: A0JL26
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

7955:ccnf
gene id: 7955:ccnf
uniprot id: Q6NYX6
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Component of the SCF(CCNF) complex.
messages: Expressed in the brain.
messages: Initially ubiquitous expression at 12 hours post-fertilization (hpf), then strongly expressed in the central nervous system by 48 hpf (PubMed:28444311). Strongly expressed in the brain up to 5 days post-fertilization (dpf) (PubMed:28444311). Ongoing expression in whole brain tissue beyond 5 dpf into adulthood (PubMed:28444311).
messages: Nucleus
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins during G2 phase involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). May play a role in motor neuron development and axonal outgrowth (PubMed:28444311).
messages: The D box motifs (amino acid sequence RxxL) are involved in substrate binding, and may be ubiquitinated.
messages: The nuclear localization signals mediate the localization to the nucleus.
messages: centriole
messages: perinuclear region

7955:arhgdia
gene id: 7955:arhgdia
uniprot id: Q802W6
names: Similarity
messages: Belongs to the Rho GDI family.

7955:gria3b
gene id: 7955:gria3b
uniprot id: A0A286Y9Q6
uniprot id: A0A8M2B408
uniprot id: A0A8M3B5M3
uniprot id: A0A8M9PZ43
uniprot id: Q71E60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:slc47a2
gene id: 7955:slc47a2
uniprot id: A1L1P9
uniprot id: U3MYZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell membrane
messages: Membrane
messages: Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity).

7955:irge4
gene id: 7955:irge4
uniprot id: A0A8M9P7N2
uniprot id: A2RV34
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

7955:npy1r
gene id: 7955:npy1r
uniprot id: A7UD89
uniprot id: F1Q681
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:LOC572443
gene id: 7955:LOC572443
uniprot id: A0A8M9PLZ3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:si:dkey-5i3.5
gene id: 7955:si:dkey-5i3.5
uniprot id: B3DIQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

7955:fat2
gene id: 7955:fat2
uniprot id: A0A8M1QQM9
uniprot id: E7FB42
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:foxn3
gene id: 7955:foxn3
uniprot id: A0A8M9PED3
uniprot id: K7DY44
names: Subcellular Location Annotation
messages: Nucleus

7955:atoh8
gene id: 7955:atoh8
uniprot id: D2CLZ9
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Contains a degenerate basic motif not likely to bind DNA.
messages: Cytoplasm
messages: Morpholino knockdown of atoh8 causes two phenotypes. The severe phenotype displays a shrunken head, reduced eye size and fused somites and most embryos die within 3 days. The mild phenotype displays an abnormal brain shape with smaller eyes, a curved body axis with indistinct somite boundaries and frequently reduced or no circulation. In addition, the yolk extension is hardly visible starting at the beginning of tail straightening from the 17-somite stage.
messages: Nucleus
messages: Nucleus speckle
messages: Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). During development, is required for heart looping and swim bladder formation by acting in concert with GATA4 and ZFPM1 (PubMed:23836893). During the development of both the retina and skeletal muscles is required for neural retinal cell through modulating PAX6 and NEUROG3 expression and myogenic differentiation (PubMed:20532172).
messages: Weakly expressed in the heart tube at 30 hours post-fertilization (PubMed:23836893). Expressed at as early as epiboly stage, and is broadly distributed till early segmentation stage and in developing retina and skeletal muscle. In the eye, expression is detected in the optic primordium at the 6-somite stage and is steadily expressed during the invagination of the optic vesicle from its initiation to its expansion to the lens rudiment. In skeletal muscle, a faint signal is detected in muscle precursor cells at the early segmentation period, and in ventral somites from the 21-somite to 24 hour post fertilization stage. Expression decreases sharply during 36 to 48 hour post fertilization stage while it reaches its highest level at about 72 hour post fertilization stage. During this period, the distribution extends to the dorsal somites. In addition also appeared in the brain and neural crest cell (PubMed:20532172).

7955:si:cabz01029535.1
gene id: 7955:si:cabz01029535.1
uniprot id: A0A140LFM6
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At 5 dpf, expressed in larvae brain and spinal cord.
messages: Belongs to the MINAR family.
messages: Cell membrane
messages: Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. Negatively regulates angiogenesis. Negatively regulates cell growth (By similarity). May play a role in neuronal development (PubMed:30080879).
messages: MINAR1 topology is a matter of debate, some authors think the N-terminus is extracellular, while preliminary experimental results suggest a cytosolic location.
messages: Mutant animals show no gross developmental abnormalities. They have enhanced fear-evoked freezing and compromised C-start responses. Mutant brains exhibit up-regulation of mTOR signaling.

7955:mstna
gene id: 7955:mstna
uniprot id: B3DJZ7
uniprot id: Q68IN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

7955:map2k5
gene id: 7955:map2k5
uniprot id: A0A8M3BB07
uniprot id: A9JRD0
uniprot id: B1NA67
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:slc6a11b
gene id: 7955:slc6a11b
uniprot id: A0A8M6Z396
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:or128-4
gene id: 7955:or128-4
uniprot id: Q2PRG1
names: Subcellular Location Annotation
messages: Membrane

7955:rps8a
gene id: 7955:rps8a
uniprot id: P62247
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

7955:cxcl11.8
gene id: 7955:cxcl11.8
uniprot id: A0A8M1NHE0
uniprot id: A2BHJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:dyrk2
gene id: 7955:dyrk2
uniprot id: A0A0R4ITS5
uniprot id: A0A2R8QCS7
uniprot id: A0A8M2BBR5
uniprot id: A0A8M2BC06
uniprot id: A4QP29
uniprot id: Q5RHV3
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

7955:cct8
gene id: 7955:cct8
uniprot id: A0A0R4IJT8
uniprot id: A0A8M2B296
uniprot id: B2GQA3
uniprot id: Q7ZU96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

7955:nrarpb
gene id: 7955:nrarpb
uniprot id: Q7T3X9
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the NRARP family.
messages: First detected at low levels in the blastula stage and begins to accumulate in the margin of the blastoderm. At the shield stage, when gastrulation starts, expression is higher on the dorsal site. As gastrulation proceeds, expressed at high levels in the anterior ectoderm. In the 1 day old embryo, at the early pharyngula stage, expression in the developing brain is very strong and expression extends in to the spinal cord.
messages: Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development.

7955:syt2a
gene id: 7955:syt2a
uniprot id: A0A8M2BLD2
uniprot id: A0A8M9P5C1
uniprot id: F1R5C0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

7955:LOC100004921
gene id: 7955:LOC100004921
uniprot id: A0A8M9PWU4
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:taar13e
gene id: 7955:taar13e
uniprot id: Q5QNP8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:pus10
gene id: 7955:pus10
uniprot id: A8KB22
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

7955:si:ch211-126g16.10
gene id: 7955:si:ch211-126g16.10
uniprot id: A0A8M1NHP2
uniprot id: B0UXE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:tgm2b
gene id: 7955:tgm2b
uniprot id: Q1ECX3
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

7955:gpc1b
gene id: 7955:gpc1b
uniprot id: Q7T3D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: extracellular space

7955:setb
gene id: 7955:setb
uniprot id: A0A8M2B801
uniprot id: Q6TGU0
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7955:spdl1
gene id: 7955:spdl1
uniprot id: A0A8M9QGH1
uniprot id: A7MD70
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spindly family.
messages: Contaminating sequence. Potential poly-A sequence.
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity).
messages: kinetochore

7955:lrrc39
gene id: 7955:lrrc39
uniprot id: F1R6I3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress (By similarity). May regulate expression of other M-band proteins via an SRF-dependent pathway (By similarity). Important for normal contractile function in heart (PubMed:20847312).
messages: M line
messages: Morpholino knockdown of the protein results in severe contractile dysfunction of the heart, leading to pericaridal edema and blood congestion. Heart development and gross cardiac morphology appear to be normal. Cardiomyocytes show some ultrastructural abnormalities including narrowing of the M-band and a poorly defined A-band/M-band transition.

7955:atp1b2a
gene id: 7955:atp1b2a
uniprot id: A0A8M9PKU7
uniprot id: Q6AZA3
uniprot id: Q9DGL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

7955:gtf2e1
gene id: 7955:gtf2e1
uniprot id: Q5SQE1
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

7955:gfra2b
gene id: 7955:gfra2b
uniprot id: A0A8N7UT76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane

7955:p4ha2
gene id: 7955:p4ha2
uniprot id: A0A286Y8C8
uniprot id: A0A8M2BL71
uniprot id: A0A8M2BL82
uniprot id: A0A8M2BLK0
uniprot id: A0A8M3ALV0
uniprot id: A0A8M3AX68
uniprot id: Q6DG45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

7955:b4galt2
gene id: 7955:b4galt2
uniprot id: A8WHZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

7955:LOC100334176
gene id: 7955:LOC100334176
uniprot id: A0A8M1RSB5
uniprot id: A0A8M3B0G7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:shbg
gene id: 7955:shbg
uniprot id: Q64HD0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ebf1b
gene id: 7955:ebf1b
uniprot id: A0A286YBI5
uniprot id: A0A8M2B8M6
uniprot id: A0A8M9P423
uniprot id: A0A8N7TEM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

7955:cactin
gene id: 7955:cactin
uniprot id: A0A8M2BFR6
uniprot id: F1Q8W0
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CACTIN family.
messages: Both maternally and zygotically expressed. Expressed at all stages of early development. Expressed from 8-cell stage to 48 hours post-fertilization (hpf). Expressed in the eyes at 48 hpf.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). May be involved in the regulation of innate immune response (By similarity). Plays a role during early embryonic development (PubMed:20348034). Involved in the formation of the anteroposterior axis with important roles also in neural development (PubMed:20348034).

7955:shroom2b
gene id: 7955:shroom2b
uniprot id: A0A8M2BK57
uniprot id: A0A8M6Z1U7
uniprot id: A0A8M9PVT4
uniprot id: A0A8N7UST7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

7955:si:dkey-61p9.6
gene id: 7955:si:dkey-61p9.6
uniprot id: A4QN42
names: Similarity
messages: Belongs to the heat shock protein 70 family.

7955:dclk3
gene id: 7955:dclk3
uniprot id: A0A8M3B3T5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

7955:LOC110439819
gene id: 7955:LOC110439819
uniprot id: A0A8M9PLC5
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:si:dkey-7e14.3
gene id: 7955:si:dkey-7e14.3
uniprot id: A0A8M1NX77
uniprot id: E7F8H3
names: Subcellular Location Annotation
messages: Nucleus

7955:zgc:171967
gene id: 7955:zgc:171967
uniprot id: A0A8M3BA22
uniprot id: A0A8M9QDG6
uniprot id: B3DIZ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

7955:gig2p
gene id: 7955:gig2p
uniprot id: A5PMV4
uniprot id: F2WZ39
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:LOC570405
gene id: 7955:LOC570405
uniprot id: A0A8M6Z1M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus

7955:mpp2a
gene id: 7955:mpp2a
uniprot id: A0A8M9PW92
uniprot id: F1QV76
names: Similarity
messages: Belongs to the MAGUK family.

7955:htra3a
gene id: 7955:htra3a
uniprot id: Q6DBR1
names: Similarity
messages: Belongs to the peptidase S1C family.

7955:c5
gene id: 7955:c5
uniprot id: A0A8M1QL13
uniprot id: E7FCV2
names: Subcellular Location Annotation
messages: Secreted

7955:LOC100535016
gene id: 7955:LOC100535016
uniprot id: A0A8M6Z3T7
names: Similarity
messages: Belongs to the glutamine synthetase family.

7955:cul2
gene id: 7955:cul2
uniprot id: A0A8M9P612
uniprot id: E9QCA9
names: Similarity
messages: Belongs to the cullin family.

7955:epoa
gene id: 7955:epoa
uniprot id: B1N8Y1
uniprot id: B1N8Y2
uniprot id: B3DI26
uniprot id: Q2XNF5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EPO/TPO family.
messages: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
messages: Expressed in heart and liver.
messages: N-glycosylated.
messages: Secreted

7955:slc29a4
gene id: 7955:slc29a4
uniprot id: A0A8M2BBN6
uniprot id: A1L272
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine (By similarity).
messages: Membrane

7955:fam73b
gene id: 7955:fam73b
uniprot id: Q5BLE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitoguardin family.
messages: Homodimer and heterodimer; forms heterodimers with miga1.
messages: Mitochondrion outer membrane
messages: Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of pld6/MitoPLD dimers. May act by regulating phospholipid metabolism via pld6/MitoPLD.

7955:si:dkey-21e5.1
gene id: 7955:si:dkey-21e5.1
uniprot id: A0A8M9PLK9
uniprot id: A0A8M9PZ66
uniprot id: A0A8M9PZ72
uniprot id: A0A8M9Q4Y2
uniprot id: A0A8M9Q9W1
uniprot id: A0A8M9QEY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:nr4a2b
gene id: 7955:nr4a2b
uniprot id: Q6DH08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Nucleus

7955:ablim2
gene id: 7955:ablim2
uniprot id: A0A8M3AYF8
uniprot id: A0A8M3AYH6
uniprot id: A0A8M3B4P9
uniprot id: A0A8M3B4Q6
uniprot id: A0A8M3B7I4
uniprot id: A0A8M3B7I9
uniprot id: A0A8M3BE85
uniprot id: A0A8M9PX20
uniprot id: A0A8M9Q905
uniprot id: A0A8M9QJ63
uniprot id: A0A8M9QMX6
names: Subcellular Location Annotation
messages: Cytoplasm

7955:micu1
gene id: 7955:micu1
uniprot id: A4IG32
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICU1 family. MICU1 subfamily.
messages: Homohexamer; in absence of calcium. Forms a homohexamer in absence of calcium and rearranges into a heterodimer in presence of calcium. Heterodimer; disulfide-linked; heterodimerizes with MICU2. The heterodimer formed with MICU2 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level. Component of the uniplex complex.
messages: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. micu1 and micu2 form a disulfide-linked heterodimer that stimulates and inhibits mcu activity, depending on the concentration of calcium. Micu1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of mcu at low concentration of calcium, preventing channel opening. Enhances mcu opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The C-helix is required for assembling the Ca(2+)-free homohexamer. It also plays a key role in mitochondrial calcium uptake, probably by mediating interaction with MICU2.
messages: The EF-hand domains have high affinity for calcium and act as sensors of calcium levels.

7955:si:dkey-117i10.1
gene id: 7955:si:dkey-117i10.1
uniprot id: A0A8M1P8T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:shroom1
gene id: 7955:shroom1
uniprot id: A0A0R4ITP7
uniprot id: A0A8N7TET4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

7955:gdi1
gene id: 7955:gdi1
uniprot id: A0A8M1N618
uniprot id: A2AR68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

7955:ms4a17c.1
gene id: 7955:ms4a17c.1
uniprot id: A0A8M1P8I9
names: Similarity
messages: Belongs to the MS4A family.

7955:uts2a
gene id: 7955:uts2a
uniprot id: F1QEG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

7955:emg1
gene id: 7955:emg1
uniprot id: Q1RM81
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

7955:lmnb1
gene id: 7955:lmnb1
uniprot id: F1QHC4
uniprot id: Q803N8
names: Similarity
messages: Belongs to the intermediate filament family.

7955:sec23a
gene id: 7955:sec23a
uniprot id: B2GSV7
uniprot id: Q7SZE5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The Gelsolin-like repeat mediates interaction with proteins containing PPP motifs.
messages: cytosol

7955:smim15
gene id: 7955:smim15
uniprot id: A3KNM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

7955:dscc1
gene id: 7955:dscc1
uniprot id: B2GRP8
uniprot id: Q66I84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DCC1 family.
messages: Component of the ctf18-RFC complex which consists of ctf18, ctf8, dscc1 and the RFC complex.
messages: Loads pcna onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion (By similarity).
messages: Nucleus

7955:zgc:92818
gene id: 7955:zgc:92818
uniprot id: Q6DGQ4
names: Similarity
messages: Belongs to the UPF0547 family.

7955:mdm2
gene id: 7955:mdm2
uniprot id: A0A0R4ISQ1
uniprot id: A0A8M2BC69
uniprot id: Q561Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

7955:eif2s3
gene id: 7955:eif2s3
uniprot id: F1QGW6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Morpholino knockdown of eif2s3 produces morphants characterized by hypomotility and morphological deficits at 2 dpf. They are shorter with a curved tail. They also display a significant reduction of head size and small eyes.
messages: The eukaryotic translation initiation factor 2 complex/eIF2 is a heterotrimer composed of an alpha, a beta and a gamma subunit.

7955:ppm1ba
gene id: 7955:ppm1ba
uniprot id: Q68FN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

7955:slc28a1
gene id: 7955:slc28a1
uniprot id: A0A8M2B698
uniprot id: A2RV43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

7955:zgc:165518
gene id: 7955:zgc:165518
uniprot id: A0A8M1NE63
uniprot id: F1QIP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

7955:mcee
gene id: 7955:mcee
uniprot id: Q502B7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

7955:tm9sf1
gene id: 7955:tm9sf1
uniprot id: A0A8M9PFX6
uniprot id: Q6DC05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

7955:tac4
gene id: 7955:tac4
uniprot id: I3ITI0
uniprot id: I4IYB7
names: Similarity
messages: Belongs to the tachykinin family.

7955:prkceb
gene id: 7955:prkceb
uniprot id: B8A467
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

7955:ak8
gene id: 7955:ak8
uniprot id: Q502L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.
messages: cytosol

7955:si:ch211-71m22.3
gene id: 7955:si:ch211-71m22.3
uniprot id: A0A8M3AW14
uniprot id: A0A8M6Z868
uniprot id: A0A8N1Z172
uniprot id: A5WVT5
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

7955:fbn2
gene id: 7955:fbn2
uniprot id: A0A8M9PTW5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:meox1
gene id: 7955:meox1
uniprot id: A0A8M9PW63
uniprot id: F1Q4R9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Defects in somite lineages. Secondary trunk myogenesis is reduced, as well as appendicular and hypaxial muscles and their progenitors. These cell types derive from the external cell layer (ECL) and ECL cell numbers are reduced. The endotome is expanded at the expense of a second somitic cell type. The resulting increase in endotome-derived cells that migrate to colonize the dorsal aorta generates a dramatic increase in chemokine-dependent hematopoietic stem cell (HSCs) induction.
messages: Expressed within the early somite and then becomes restricted to the external cell layer (ECL) and consequently to appendicular muscle populations.
messages: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by mediating specification of endothelial cells of the endotome within the nascent somite, notably by repressing expression of cxcl12b.
messages: Nucleus

7955:pkn3
gene id: 7955:pkn3
uniprot id: A0A8M9Q469
uniprot id: E7F7I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

7955:gnb2l1
gene id: 7955:gnb2l1
uniprot id: O42248
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: Cytoplasm
messages: Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation.

7955:cox18
gene id: 7955:cox18
uniprot id: A0A8M3AGY1
uniprot id: A0A8M9PZ05
uniprot id: A9JTC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

7955:rps27.1
gene id: 7955:rps27.1
uniprot id: Q4VBV2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

7955:dner
gene id: 7955:dner
uniprot id: S4TYY2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:appa
gene id: 7955:appa
uniprot id: Q6NUZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:srpk3
gene id: 7955:srpk3
uniprot id: A0A8M2BE87
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:pdcd10b
gene id: 7955:pdcd10b
uniprot id: Q6NWL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Interacts (via C-terminus) with CCM2. Interacts (via N-terminus) with STK25 and STK26.
messages: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development (PubMed:19370760).

7955:eif3k
gene id: 7955:eif3k
uniprot id: A0A8M6YUR6
uniprot id: Q567V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Nucleus

7955:med11
gene id: 7955:med11
uniprot id: A3KNK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:ribc1
gene id: 7955:ribc1
uniprot id: A0A8M1ND12
uniprot id: F1R3H7
names: Similarity
messages: Belongs to the RIB43A family.

7955:pax5
gene id: 7955:pax5
uniprot id: A0A8M1PBT6
uniprot id: A0A8M2BI63
uniprot id: A0A8M2BI96
uniprot id: F1QGF8
names: Subcellular Location Annotation
messages: Nucleus

7955:tubb6
gene id: 7955:tubb6
uniprot id: A0A0R4IXC8
uniprot id: A0A8M1N5M5
uniprot id: A0A8M1PAC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:dnph1
gene id: 7955:dnph1
uniprot id: B8A556
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus

7955:mslna
gene id: 7955:mslna
uniprot id: A0A8M9PTN4
uniprot id: A0A8M9PZM5
uniprot id: A0A8M9QAJ5
names: Similarity
messages: Belongs to the mesothelin family.

7955:si:ch211-260e23.7
gene id: 7955:si:ch211-260e23.7
uniprot id: A0A0R4IF73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

7955:zp2.6
gene id: 7955:zp2.6
uniprot id: A0A8M1PCA2
uniprot id: F1QJ26
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:unc93a
gene id: 7955:unc93a
uniprot id: A0A8M2BHJ1
uniprot id: Q5SPF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

7955:plrg1
gene id: 7955:plrg1
uniprot id: Q6DRE2
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

7955:mfsd4ab
gene id: 7955:mfsd4ab
uniprot id: A9JTG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

7955:tspan4b
gene id: 7955:tspan4b
uniprot id: A3KP80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:zgc:158773
gene id: 7955:zgc:158773
uniprot id: A2VD46
names: Subcellular Location Annotation
messages: Membrane

7955:foxi3b
gene id: 7955:foxi3b
uniprot id: Q7T1C0
names: Subcellular Location Annotation
messages: Nucleus

7955:cyp2k6
gene id: 7955:cyp2k6
uniprot id: F1Q8C3
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Detected in liver and ovary.
messages: Endoplasmic reticulum membrane
messages: Expressed from 5 days post-fertilization onwards.
messages: Metabolizes aflatoxin B1 (AFB1) to the cytotoxic derivative AFB1 exo-8,9-epoxide. Does not show activity towards lauric acid.
messages: Microsome membrane

7955:azin1a
gene id: 7955:azin1a
uniprot id: A0A8M1N598
uniprot id: F1QZN2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

7955:tspoap1
gene id: 7955:tspoap1
uniprot id: A0A8M6Z6Z8
names: Similarity
messages: Belongs to the RIMBP family.

7955:bloc1s3
gene id: 7955:bloc1s3
uniprot id: Q4V924
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S3 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
messages: Cytoplasm

7955:plpp2b
gene id: 7955:plpp2b
uniprot id: Q7SYJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7955:zgc:175280
gene id: 7955:zgc:175280
uniprot id: A9JTI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

7955:aldoaa
gene id: 7955:aldoaa
uniprot id: Q803Q7
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

7955:bri3
gene id: 7955:bri3
uniprot id: A0A8M1NWM0
uniprot id: E7FAC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

7955:tmem50a
gene id: 7955:tmem50a
uniprot id: Q803R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

7955:s1pr1
gene id: 7955:s1pr1
uniprot id: Q1LV63
uniprot id: Q9DDK4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Embryonic brain. Not detected during blastula or gastrula stages. At the 4-5 somite stage, expressed in the diencephalon just posterior to the optic vesicles, and weakly in the hindbrain. By the 14 somite stage, there is widespread expression in the CNS, particularly in the ventral diencephalon, optic stalks and anterior hindbrain.
messages: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate.
messages: Membrane

7955:rps14
gene id: 7955:rps14
uniprot id: Q6PBW3
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

7955:kcnk13a
gene id: 7955:kcnk13a
uniprot id: A8KB76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:pus3
gene id: 7955:pus3
uniprot id: Q7ZW97
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

7955:h2afx
gene id: 7955:h2afx
uniprot id: Q7ZUY3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Monoubiquitination of Lys-120 (H2AXK119ub) by ring1 and rnf2/ring2 complex gives a specific tag for epigenetic transcriptional repression. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase ube2n and the E3 ligases rnf8 and rnf168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by rnf168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; rnf8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events (By similarity).
messages: Nucleus
messages: Phosphorylated. Phosphorylation of Ser-139 (H2AX139ph) occurs in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents, by stalled replication forks and by meiotic recombination events. Phosphorylation is dependent on the DNA damage checkpoint kinases ATR and ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Widespread phosphorylation may also serve to amplify the damage signal or aid repair of persistent lesions. Dephosphorylation of Ser-139 is required for DNA DSB repair. Phosphorylation at Tyr-142 (H2AXY142ph) by baz1b/wstf determines the relative recruitment of either DNA repair or pro-apoptotic factors. Phosphorylation at Tyr-142 (H2AXY142ph) favors the recruitment of pro-apoptosis factors. In contrast, dephosphorylation of Tyr-142 by EYA proteins (eya1, eya2, eya3 or eya4) favors the recruitment of MDC1-containing DNA repair complexes to the tail of phosphorylated Ser-139 (H2AX139ph).
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with numerous proteins required for DNA damage signaling and repair when phosphorylated on Ser-139 (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation (By similarity).

7955:si:dkey-40m6.14
gene id: 7955:si:dkey-40m6.14
uniprot id: A0A8M9PDP8
uniprot id: A0A8M9PN41
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

7955:cul3a
gene id: 7955:cul3a
uniprot id: A0A8M1PBQ9
uniprot id: F6NVK8
names: Similarity
messages: Belongs to the cullin family.

7955:tet3
gene id: 7955:tet3
uniprot id: A0A2R8Q4R6
uniprot id: A0A2R8Q5Y7
uniprot id: A0A8M1P395
uniprot id: A0A8M1P9L5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

7955:gli3
gene id: 7955:gli3
uniprot id: A0A8M9PFV8
uniprot id: A0A8M9PLM1
uniprot id: Q6U6Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus

7955:fam149a
gene id: 7955:fam149a
uniprot id: A0A8M9PZZ8
names: Similarity
messages: Belongs to the FAM149 family.

7955:zgc:114046
gene id: 7955:zgc:114046
uniprot id: A7MCA7
uniprot id: Q5BJA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-111 promotes monoubiquitination of Lys-119. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-119 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: Phosphorylated during apoptosis; which facilitates apoptotic chromatin condensation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ripk3
gene id: 7955:ripk3
uniprot id: A0A8M1PSS7
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:smug1
gene id: 7955:smug1
uniprot id: A0A0G2KZ26
uniprot id: A0A8M6Z3B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

7955:ptx3b
gene id: 7955:ptx3b
uniprot id: A0A8N7UT96
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tfeb
gene id: 7955:tfeb
uniprot id: A0A2R8RRI1
uniprot id: A0A8M2BK54
uniprot id: A0A8M2BK61
uniprot id: A0A8M2BKN6
uniprot id: A0A8M9Q799
uniprot id: E7FEM8
uniprot id: G5CIM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

7955:si:ch211-232b12.5
gene id: 7955:si:ch211-232b12.5
uniprot id: A0A8M1RM49
uniprot id: E7EY09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

7955:foxd5
gene id: 7955:foxd5
uniprot id: O73784
names: Subcellular Location Annotation
messages: Nucleus

7955:olfcd2
gene id: 7955:olfcd2
uniprot id: A0A8M3AJN7
uniprot id: A0T300
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:eif2s1b
gene id: 7955:eif2s1b
uniprot id: A8E5I4
uniprot id: Q9I9E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

7955:tmem170a
gene id: 7955:tmem170a
uniprot id: A3KPL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Endoplasmic reticulum membrane
messages: May regulate membrane morphogenesis in the endoplasmic reticulum (ER) by promoting ER sheet formation at the expense of ER tubules.
messages: Nucleus envelope

7955:tars
gene id: 7955:tars
uniprot id: A0A8M9PXD7
uniprot id: A8KC60
uniprot id: Q5XIZ3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

7955:si:dkey-23a13.7
gene id: 7955:si:dkey-23a13.7
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ablim1a
gene id: 7955:ablim1a
uniprot id: A0A8M3AZG5
uniprot id: A0A8M3B5I2
uniprot id: A0A8M3B896
uniprot id: A0A8M3BEV3
uniprot id: A0A8M6Z1J7
uniprot id: A0A8M6Z923
uniprot id: A0A8M6Z9H1
uniprot id: A0A8M9PXI2
uniprot id: A0A8M9PXI8
uniprot id: A0A8M9Q9F1
uniprot id: A0A8M9Q9F5
uniprot id: A0A8M9QF47
uniprot id: A0A8M9QJF9
uniprot id: A0A8M9QJG3
uniprot id: A0A8M9QN76
uniprot id: A9JRG6
names: Subcellular Location Annotation
messages: Cytoplasm

7955:ywhaz
gene id: 7955:ywhaz
uniprot id: A0A8M1PI77
uniprot id: B8JLJ3
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

7955:galnt8a.2
gene id: 7955:galnt8a.2
uniprot id: A0A8M9PN74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:si:ch211-233f16.1
gene id: 7955:si:ch211-233f16.1
uniprot id: A0A8M6YU12
uniprot id: A0A8M6Z2H7
uniprot id: A0A8M9P216
uniprot id: A0A8M9PB81
uniprot id: A0A8M9PNP5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:acad11
gene id: 7955:acad11
uniprot id: Q7ZVN9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7955:hopx
gene id: 7955:hopx
uniprot id: Q8AYB8
names: Function
names: Subcellular Location Annotation
messages: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. May act via an interaction with SRF, leading to modulate the expression of SRF-dependent cardiac-specific genes and cardiac development (PubMed:12297045). May act as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assist in chaperone-mediated protein refolding (By similarity).
messages: Cytoplasm
messages: Nucleus

7955:piezo1
gene id: 7955:piezo1
uniprot id: A0A8N7TDV6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIEZO (TC 1.A.75) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:wnt8a
gene id: 7955:wnt8a
uniprot id: P51028
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Expressed in the margin of the pregastrula embryo destined to be the future mesoderm.
messages: Expressed in the segmental plate and ventral mesoderm during early gastrulation and early somitogenesis (PubMed:25371059). Expressed in the marginal region and in a broad domain in the ventral region after 75% epiboly (PubMed:11703928). Expressed in the tailbud during the bud stage (PubMed:11703928).
messages: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for mesoderm and neural ectoderm patterning during gastrulation (PubMed:11703928). Involved in axis formation during embryonic development, via activation of canonical Wnt/CTNNB1 signaling (PubMed:11703928, PubMed:25371059). May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis (PubMed:7600994).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
messages: Proteolytic processing by tiki1 and tiki2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of wnt8.
messages: Secreted
messages: extracellular matrix

7955:fam129bb
gene id: 7955:fam129bb
uniprot id: F1R7A2
names: Similarity
messages: Belongs to the Niban family.

7955:spam1
gene id: 7955:spam1
uniprot id: A1L264
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

7955:haus6
gene id: 7955:haus6
uniprot id: A0JMF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAUS6 family.
messages: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (By similarity).
messages: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin (By similarity).
messages: centrosome
messages: cytoskeleton
messages: spindle

7955:gna13a
gene id: 7955:gna13a
uniprot id: Q4VBH5
uniprot id: Q5YKG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

7955:icn
gene id: 7955:icn
uniprot id: Q3B7P2
uniprot id: Q6XG62
names: Similarity
messages: Belongs to the S-100 family.

7955:taar12a
gene id: 7955:taar12a
uniprot id: A0A8M1NDS4
uniprot id: Q5QNQ2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:anp32b
gene id: 7955:anp32b
uniprot id: A0A8M2B6P3
uniprot id: A0A8N1Z3N3
uniprot id: F1Q4N7
uniprot id: Q6P034
names: Similarity
messages: Belongs to the ANP32 family.

7955:slc16a9b
gene id: 7955:slc16a9b
uniprot id: Q6DBW3
names: Subcellular Location Annotation
messages: Membrane

7955:sec13
gene id: 7955:sec13
uniprot id: Q7T2E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

7955:zgc:152830
gene id: 7955:zgc:152830
uniprot id: Q08CQ0
names: Similarity
messages: Belongs to the peptidase M17 family.

7955:atp10b
gene id: 7955:atp10b
uniprot id: E7FFI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

7955:lrrc8aa
gene id: 7955:lrrc8aa
uniprot id: Q4V8W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

7955:rps6kb1a
gene id: 7955:rps6kb1a
uniprot id: A0A8N7UVV0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

7955:irf6
gene id: 7955:irf6
uniprot id: Q52YL6
uniprot id: Q6PGZ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:fgf8a
gene id: 7955:fgf8a
uniprot id: O57341
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Expressed in Kupffer's vesicle.
messages: Monomer (By similarity). Homodimer (By similarity).
messages: Morpholino knockdown of the protein causes a dramatic loss of cilia in Kupffer's vesicle.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis (PubMed:19164561).
messages: Secreted

7955:LOC101882407
gene id: 7955:LOC101882407
uniprot id: A0A8M2BKT3
uniprot id: E7EYF8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:borcs8
gene id: 7955:borcs8
uniprot id: A0A8M2BHT0
uniprot id: A3KQI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

7955:lzic
gene id: 7955:lzic
uniprot id: Q6DHH7
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CTNNBIP1 family.
messages: Does not interact with CTNNB1.
messages: Expressed very early in development. Expression levels drop until shield stage and increase again during gastrulation and later development. Expressed abundantly in the developing brain, and at lower levels throughout the embryo.
messages: Required for neuronal survival during early development.

7955:parp4
gene id: 7955:parp4
uniprot id: A0A8M6Z886
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:pfkma
gene id: 7955:pfkma
uniprot id: Q66HV8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:egr1
gene id: 7955:egr1
uniprot id: B3DKJ7
uniprot id: P26632
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine.
messages: Cytoplasm
messages: Detected in muscle and brain.
messages: Nucleus
messages: Transcriptional regulator (PubMed:7945937). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays a role in regulating the expression of circadian clock genes (By similarity).
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

7955:xrn2
gene id: 7955:xrn2
uniprot id: A0A0R4ISJ3
uniprot id: A0A8M1MZQ7
uniprot id: A0A8M2B7S3
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

7955:si:ch211-194m7.5
gene id: 7955:si:ch211-194m7.5
uniprot id: A0A8M6YVZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pleca
gene id: 7955:pleca
uniprot id: A0A8M1NF92
uniprot id: A0A8M9P1W1
uniprot id: A0A8M9P1W5
uniprot id: A0A8M9P1W8
uniprot id: A0A8M9P1X0
uniprot id: A0A8M9PB19
uniprot id: A0A8M9PB23
uniprot id: A0A8M9PB27
uniprot id: A0A8M9PB30
uniprot id: A0A8M9PGI1
uniprot id: A0A8M9PGI7
uniprot id: A0A8M9PGJ1
uniprot id: A0A8M9PGJ7
uniprot id: A0A8M9PNE8
uniprot id: A0A8M9PNF5
uniprot id: A0A8M9PNG2
uniprot id: A0A8M9PNG8
uniprot id: A0A8M9PRN8
uniprot id: A0A8M9PRP2
uniprot id: A0A8M9PRQ0
uniprot id: A0A8M9PRQ7
uniprot id: A0A8M9PRR5
uniprot id: A5WV02
names: Subcellular Location Annotation
messages: cytoskeleton

7955:lig3
gene id: 7955:lig3
uniprot id: A0A8M1N7I1
uniprot id: F1QJL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

7955:kif21b
gene id: 7955:kif21b
uniprot id: A0A8M3AXD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

7955:gngt1
gene id: 7955:gngt1
uniprot id: Q6PBN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:ndrg3a
gene id: 7955:ndrg3a
uniprot id: A0A8M2BGH5
uniprot id: A0A8M9PUP4
uniprot id: E7FEZ7
uniprot id: Q7SY38
names: Similarity
messages: Belongs to the NDRG family.

7955:nr1d2a
gene id: 7955:nr1d2a
uniprot id: A0A8N7UZ57
uniprot id: F1QIC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

7955:etv4
gene id: 7955:etv4
uniprot id: A0A8M3AY95
uniprot id: A0A8N1TV56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:zgc:136336
gene id: 7955:zgc:136336
uniprot id: A0A8M3B7Z7
uniprot id: Q1JQ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

7955:map4k2
gene id: 7955:map4k2
uniprot id: Q1RLZ2
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

7955:pxylp1
gene id: 7955:pxylp1
uniprot id: Q6DH46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family.
messages: Golgi apparatus membrane
messages: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases.

7955:fras1
gene id: 7955:fras1
uniprot id: A0A0R4IQJ3
uniprot id: A0A8M1NJ29
uniprot id: A0A8M2BCL6
uniprot id: A0A8M3AZT2
uniprot id: A0A8M9Q8W1
uniprot id: F1Q633
names: Similarity
messages: Belongs to the FRAS1 family.

7955:sumo1
gene id: 7955:sumo1
uniprot id: Q7SZR5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cell membrane
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with sae2, ube2i, ranbp2, pias1 and pias2 (By similarity). Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: Nucleus membrane
messages: Nucleus speckle
messages: PML body
messages: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

7955:edem2
gene id: 7955:edem2
uniprot id: A0A0R4IAP0
uniprot id: A0A8M1P1W0
uniprot id: A0A8M9PKN4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

7955:slc25a3a
gene id: 7955:slc25a3a
uniprot id: A0A8M2BBW5
uniprot id: Q6PC47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

7955:snx9b
gene id: 7955:snx9b
uniprot id: A0A8M2BI00
uniprot id: A0A8M9PBT0
uniprot id: A0A8M9PHD2
uniprot id: B3DJS3
uniprot id: Q5SPP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

7955:prkacba
gene id: 7955:prkacba
uniprot id: Q7T374
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

7955:si:ch73-352p4.8
gene id: 7955:si:ch73-352p4.8
uniprot id: A0A8N7T6Q9
uniprot id: F1QSV1
names: Subcellular Location Annotation
messages: Membrane

7955:stt3b
gene id: 7955:stt3b
uniprot id: A0A8M1P4G3
uniprot id: E7EZE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

7955:ak1
gene id: 7955:ak1
uniprot id: A0A8M2BGJ7
uniprot id: Q68EH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

7955:tmem150ab
gene id: 7955:tmem150ab
uniprot id: Q7SXK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRAM/TMEM150 family.
messages: Cell membrane
messages: Membrane

7955:cacna1ab
gene id: 7955:cacna1ab
uniprot id: A0A8M6Z3D5
uniprot id: A0A8M9PUZ6
uniprot id: A0A8M9PV04
uniprot id: A0A8M9PV10
uniprot id: A0A8M9Q7A3
uniprot id: A0A8M9Q7B0
uniprot id: A0A8M9Q7B5
uniprot id: A0A8M9QD59
uniprot id: A0A8M9QD65
uniprot id: A0A8M9QD71
uniprot id: A0A8M9QHQ9
uniprot id: A0A8M9QHR4
uniprot id: A0A8M9QHR9
uniprot id: A0A8M9QLP2
uniprot id: A0A8M9QLP7
uniprot id: A0A8M9QLQ1
uniprot id: A0A8N7XJK3
uniprot id: F8W3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane

7955:hsd17b4
gene id: 7955:hsd17b4
uniprot id: A0A8M9PQQ8
uniprot id: B2GSU8
uniprot id: Q8AYH1
names: Subcellular Location Annotation
messages: Peroxisome

7955:srpx2
gene id: 7955:srpx2
uniprot id: A0A8M1RE00
uniprot id: A0A8M9QL27
uniprot id: E7F8X0
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

7955:fgfbp2a
gene id: 7955:fgfbp2a
uniprot id: A0A8M1Q161
uniprot id: F1R8L1
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

7955:thbs2a
gene id: 7955:thbs2a
uniprot id: A0A8M3B5F4
uniprot id: F8W5Z7
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ankrd45
gene id: 7955:ankrd45
uniprot id: B0S794
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Ankrd45 mutants are viable and show no apparent defects. However mutant larvae developed enlarged livers when induced with liver specific expression of Kras G12V, one of the common mutations of KRAS that leads to cancer in humans.
messages: Cleavage furrow
messages: Cytoplasm
messages: May play a role during cell division.
messages: Midbody ring
messages: Weakly detected in the dorsal forerunner cells at 80% epiboly to bud stages. At the 10-somite stage, strong expression is detected in the otic placodes, Kupffer's vesicles, and floor plate. Later, at 24 h post-fertilization, is mainly expressed in organs rich in motile cilia, including otic vesicles, pronephric ducts, and floor plates. At later stages, displays a ubiquitous expression pattern.
messages: Widely expressed.

7955:mat2aa
gene id: 7955:mat2aa
uniprot id: F1QYU7
uniprot id: H9MZH3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

7955:abcd3a
gene id: 7955:abcd3a
uniprot id: A0A8M9PXC6
uniprot id: Q803I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

7955:bdh2
gene id: 7955:bdh2
uniprot id: Q561X9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Detected in embryos.
messages: Homotetramer.
messages: Morpholino knockdown of the protein causes no gross defects in embryos, with the exception of hypochromic blood due to decreased hemoglobin levels.
messages: NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (By similarity). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (By similarity).

7955:gadd45ga
gene id: 7955:gadd45ga
uniprot id: Q6P021
names: Similarity
messages: Belongs to the GADD45 family.

7955:crybg3
gene id: 7955:crybg3
uniprot id: A0A8M9Q687
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:ponzr6
gene id: 7955:ponzr6
uniprot id: A0A8M1P8H1
uniprot id: E7FAV8
names: Similarity
messages: Belongs to the cornifelin family.

7955:si:ch73-236c18.3
gene id: 7955:si:ch73-236c18.3
uniprot id: A0A8M6Z1J8
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

7955:ogdhl
gene id: 7955:ogdhl
uniprot id: A0A8N7UVR5
uniprot id: E7FGK9
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

7955:tysnd1
gene id: 7955:tysnd1
uniprot id: B3DFU6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

7955:eif4e2rs1
gene id: 7955:eif4e2rs1
uniprot id: A0A8M6YXN8
uniprot id: Q6PBU4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

7955:retreg1
gene id: 7955:retreg1
uniprot id: A0A2R8QB28
uniprot id: A0A8M1Q245
uniprot id: A0A8M2BAN5
uniprot id: A0A8M9PLU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

7955:nkx2.2a
gene id: 7955:nkx2.2a
uniprot id: F1QNE4
names: Subcellular Location Annotation
messages: Nucleus

7955:mid1ip1l
gene id: 7955:mid1ip1l
uniprot id: B2GNN4
uniprot id: Q8AWD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Involved in stabilization of microtubules. May play a role in the regulation of lipogenesis (By similarity).
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: Nucleus
messages: cytoskeleton

7955:suclg1
gene id: 7955:suclg1
uniprot id: Q66I58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

7955:gabrb3
gene id: 7955:gabrb3
uniprot id: A0A0R4ILP2
uniprot id: A0A8M2BDH7
uniprot id: A0A8M9PYR4
uniprot id: E7EXG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:slc5a12
gene id: 7955:slc5a12
uniprot id: Q7T384
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate.
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Expressed in brain and eye 24, 72 and 120 hours post-fertilization (hpf). At 72 hpf expressed in swim bladder and in pronephric tube. At 120 hpf expressed in brain, trabecular bar, eyes, otic capsule, stomach, gall bladder, gut and pancreas.
messages: Membrane

7955:irf2bp2a
gene id: 7955:irf2bp2a
uniprot id: Q6NZT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor.
messages: Belongs to the IRF2BP family.
messages: Nucleus

7955:tspan18b
gene id: 7955:tspan18b
uniprot id: A0A8M2B5N2
uniprot id: A0A8M6YU47
uniprot id: A3KQH0
uniprot id: Q6DH58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:emc6
gene id: 7955:emc6
uniprot id: Q6P0F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.

7955:ndufs5
gene id: 7955:ndufs5
uniprot id: Q502P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

7955:si:ch211-186j3.6
gene id: 7955:si:ch211-186j3.6
uniprot id: A0A8M1QQU9
uniprot id: F1QK15
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:cga
gene id: 7955:cga
uniprot id: Q6QX43
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer of an alpha and a beta chain.
messages: Secreted

7955:sephs1
gene id: 7955:sephs1
uniprot id: Q7ZW38
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class II subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Cell membrane
messages: Homodimer.
messages: Nucleus membrane
messages: Synthesizes selenophosphate from selenide and ATP.
messages: The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is probable, it is possible Cys-31 is the active site.

7955:dtd1
gene id: 7955:dtd1
uniprot id: F1QGC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: D-aminoacyl-tRNA deacylase, with no observable activity on tRNAs charged with their cognate L-amino acid (By similarity). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) (PubMed:27224426). Deacylates mischarged D.melanogaster and E.coli glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (PubMed:28362257). Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity).
messages: Homodimer.

7955:zbtb8os
gene id: 7955:zbtb8os
uniprot id: Q566V0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with ddx1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (By similarity).
messages: Component of the tRNA-splicing ligase complex.

7955:ppfia3
gene id: 7955:ppfia3
uniprot id: A0A8M1RLT7
uniprot id: A0A8M9Q8T7
uniprot id: X1WCJ5
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

7955:crebbpb
gene id: 7955:crebbpb
uniprot id: A0A8M9PNF9
uniprot id: A0A8M9PUL2
uniprot id: A0A8M9Q1N8
names: Subcellular Location Annotation
messages: Cytoplasm

7955:tlcd1
gene id: 7955:tlcd1
uniprot id: Q5XJP8
names: Subcellular Location Annotation
messages: Membrane

7955:spoplb
gene id: 7955:spoplb
uniprot id: A0JMG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tdpoz family.
messages: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency.
messages: Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL (By similarity).
messages: Nucleus

7955:axl
gene id: 7955:axl
uniprot id: A0A8M6Z1G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

7955:spega
gene id: 7955:spega
uniprot id: Q696W0
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: May be autophosphorylated.
messages: Nucleus
messages: Preferentially expressed in striated muscle.

7955:caskb
gene id: 7955:caskb
uniprot id: B6EUL7
names: Similarity
messages: Belongs to the MAGUK family.

7955:irf2
gene id: 7955:irf2
uniprot id: A0A0R4IBK0
uniprot id: A0A8M1P2X6
uniprot id: A0A8M1P3S1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:pipox
gene id: 7955:pipox
uniprot id: A0A8M1P8J4
uniprot id: Q1JQ42
names: Similarity
messages: Belongs to the MSOX/MTOX family.

7955:zgc:172145
gene id: 7955:zgc:172145
uniprot id: A0A8M9PMR3
uniprot id: B1WB56
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

7955:tbc1d32
gene id: 7955:tbc1d32
uniprot id: Q5RHR6
names: Caution
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Fish are viable during embryogenesis and early larval stages, but exhibit curvature of the body axis and hydrocephalus, and curled cilia in distal kidney tubules.
messages: Interacts with cdk20, which promotes cdk20 stability and function.
messages: Required for high-level Shh responses in the developing neural tube. Together with cdk20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.
messages: The Rab-GAP TBC domain appears to be inactive, probably due to a lack of the essential Arg and Gln in the catalytic finger motifs.
messages: cilium

7955:ccdc124
gene id: 7955:ccdc124
uniprot id: Q6PHE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Midbody
messages: Required for proper progression of late cytokinetic stages.
messages: centrosome

7955:si:dkey-96f10.1
gene id: 7955:si:dkey-96f10.1
uniprot id: A0A8M1RL50
uniprot id: A0A8M2B8X9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

7955:LOC556735
gene id: 7955:LOC556735
uniprot id: A0A8N7UQP5
uniprot id: E7F2I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

7955:pgap2
gene id: 7955:pgap2
uniprot id: A0A8M2B8B3
uniprot id: G1K2N7
uniprot id: Q5BL33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

7955:maml1
gene id: 7955:maml1
uniprot id: A0A0R4IKI2
uniprot id: A0A8M2B411
uniprot id: A0A8N7TF91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

7955:irf2bp2b
gene id: 7955:irf2bp2b
uniprot id: Q7T2G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional repressor.
messages: Belongs to the IRF2BP family.
messages: Nucleus

7955:tm7sf2
gene id: 7955:tm7sf2
uniprot id: Q5PR41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

7955:tulp4b
gene id: 7955:tulp4b
uniprot id: A0A8M9PP39
names: Similarity
messages: Belongs to the TUB family.

7955:chia.5
gene id: 7955:chia.5
uniprot id: B7ZVM0
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7955:LOC101886252
gene id: 7955:LOC101886252
uniprot id: A0A8M9QEB5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:LOC100006895
gene id: 7955:LOC100006895
uniprot id: A0A8M1QLT2
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

7955:rcl1
gene id: 7955:rcl1
uniprot id: A0A8M9Q8F5
uniprot id: Q6DRI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

7955:nudt6
gene id: 7955:nudt6
uniprot id: A3KNL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

7955:rrp8
gene id: 7955:rrp8
uniprot id: A0A8M1PYX1
uniprot id: A0A8M6YSH0
uniprot id: F1R692
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Probable methyltransferase required to silence rDNA.
messages: nucleolus

7955:kif18a
gene id: 7955:kif18a
uniprot id: Q7ZUW9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:stx11a
gene id: 7955:stx11a
uniprot id: Q6NXB1
names: Similarity
messages: Belongs to the syntaxin family.

7955:lap3
gene id: 7955:lap3
uniprot id: A0A8M1NGB5
uniprot id: A2BIC6
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

7955:LOC100329231
gene id: 7955:LOC100329231
uniprot id: A0A8M9P017
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:adam22
gene id: 7955:adam22
uniprot id: A0A8M1RE30
uniprot id: A0A8M3AJF6
uniprot id: A0A8M3ATT0
uniprot id: A0A8M9P8I9
uniprot id: A0A8M9PDU9
uniprot id: F1QF43
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:162611
gene id: 7955:zgc:162611
uniprot id: Q4QRF4
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin (By similarity).
messages: Serine ADP-ribosylation by PARP1 or PARP2 constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) promotes recruitment of CHD1L. H3S10ADPr is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:olfcg1
gene id: 7955:olfcg1
uniprot id: A0A0R4IJ62
uniprot id: A0A8M1NRE7
uniprot id: A0A8M9PLV3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:slc9a3r1a
gene id: 7955:slc9a3r1a
uniprot id: Q6P2U7
names: Function
names: Subcellular Location Annotation
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
messages: filopodium
messages: microvillus
messages: ruffle

7955:hmces
gene id: 7955:hmces
uniprot id: A5PLB0
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

7955:si:dkey-211g8.4
gene id: 7955:si:dkey-211g8.4
uniprot id: A0A8M2B646
uniprot id: Q1L957
names: Subcellular Location Annotation
messages: Nucleus

7955:adgrf3a
gene id: 7955:adgrf3a
uniprot id: A0A8M9PL11
uniprot id: A0A8M9PP29
names: Subcellular Location Annotation
messages: Membrane

7955:pth1rb
gene id: 7955:pth1rb
uniprot id: A0A8M9QMD4
uniprot id: Q9PVD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

7955:mfsd6l
gene id: 7955:mfsd6l
uniprot id: Q6DBX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

7955:slc29a1a
gene id: 7955:slc29a1a
uniprot id: F1QAM5
uniprot id: Q4V9F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

7955:scn1lab
gene id: 7955:scn1lab
uniprot id: A0A8M9Q653
uniprot id: F1QXF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

7955:si:dkey-202e17.1
gene id: 7955:si:dkey-202e17.1
uniprot id: A0A8M2BHE0
uniprot id: A3KQK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Membrane

7955:tk1
gene id: 7955:tk1
uniprot id: B2GPF2
uniprot id: Q803Y1
names: Similarity
messages: Belongs to the thymidine kinase family.

7955:acaa2
gene id: 7955:acaa2
uniprot id: Q7ZVG1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

7955:pth1ra
gene id: 7955:pth1ra
uniprot id: Q9PVD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

7955:fam167b
gene id: 7955:fam167b
uniprot id: A0A0R4IB67
uniprot id: A0A8M1QR96
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

7955:mtr
gene id: 7955:mtr
uniprot id: Q8JIY6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

7955:stx12
gene id: 7955:stx12
uniprot id: A5PMJ7
uniprot id: Q6IQS7
names: Similarity
messages: Belongs to the syntaxin family.

7955:sdad1
gene id: 7955:sdad1
uniprot id: Q6NV26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

7955:tmem237b
gene id: 7955:tmem237b
uniprot id: A0A8M3AT44
uniprot id: Q66IE4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Fishes lacking both tmem237a and tmem237b display defects in midsomitic embryos, including shortening of the anterior-posterior axis and small anterior structures, kinking of the notochord, and broadening and thinning of the somite.
messages: Membrane
messages: cilium

7955:si:ch211-283g2.1
gene id: 7955:si:ch211-283g2.1
uniprot id: A0A8M6Z6E8
uniprot id: E9QDS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:hlfa
gene id: 7955:hlfa
uniprot id: Q08BP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

7955:cyp2p8
gene id: 7955:cyp2p8
uniprot id: B3DGW6
uniprot id: Q5TZ86
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:cox7c
gene id: 7955:cox7c
uniprot id: Q6PBP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

7955:sumf1
gene id: 7955:sumf1
uniprot id: A0A8M2BDC4
uniprot id: F1QHA4
uniprot id: Q1RM47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

7955:foxj1b
gene id: 7955:foxj1b
uniprot id: F1R8Z9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FOXJ1 family.
messages: Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function.
messages: Nucleus
messages: Randomization of the left-right body.
messages: Strongly expressed in the shield, the floor plate in early somitogenesis, the posterior neural plate, the otic vesicles and later in the otoliths, the pronephric ducts, diencephalon, olfactory pits, briefly in the trigeminal ganglion, and in an anterior brain region that overlaps the pineal gland and later corresponds to the anterior tectal ventricle.

7955:lepa
gene id: 7955:lepa
uniprot id: Q0D250
names: Similarity
messages: Belongs to the leptin family.

7955:taf12
gene id: 7955:taf12
uniprot id: Q6P013
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

7955:grik1b
gene id: 7955:grik1b
uniprot id: A0A8M3AIT1
uniprot id: A0A8M3B1C5
uniprot id: A0A8N7TB31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:map1lc3cl
gene id: 7955:map1lc3cl
uniprot id: A0A8M9QBN9
names: Similarity
messages: Belongs to the ATG8 family.

7955:tgfbr2b
gene id: 7955:tgfbr2b
uniprot id: Q58EQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

7955:rhoac
gene id: 7955:rhoac
uniprot id: Q7T2E8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: (Microbial infection) Glycosylated at Tyr-34 by Yersinia ruckeri toxin Afp18. Mono-O-GlcNAcylation by Afp18 inhibits RhoA activation by guanine nucleotide exchange factors and blocks RhoA signaling.
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.

7955:fgb
gene id: 7955:fgb
uniprot id: Q6NYE1
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

7955:nlk2
gene id: 7955:nlk2
uniprot id: A0A8M6YSB2
uniprot id: B3IWJ8
uniprot id: E7F1L8
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

7955:LOC797436
gene id: 7955:LOC797436
uniprot id: A0A8M1Q1F6
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

7955:hcst
gene id: 7955:hcst
uniprot id: A0A8M1NE56
uniprot id: F1QIP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAP10 family.
messages: Membrane

7955:btaf1
gene id: 7955:btaf1
uniprot id: A0A8M2BGW0
names: Subcellular Location Annotation
messages: Nucleus

7955:es1
gene id: 7955:es1
uniprot id: Q90257
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed specifically in the inner segments of cone photoreceptor cells of the retina (at protein level).
messages: Mitochondrion
messages: Morpholino knockdown of the protein display decreased eye size and formation of smaller mitochondria in cone ellipsoid photoreceptor cells.
messages: Plays a role in promoting mitochondrial enlargement in cone photoreceptor cells in a fusion-independent and ATP-dependent manner.

7955:ranbp9
gene id: 7955:ranbp9
uniprot id: A1L252
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RANBP9/10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in the CTLH complex that contains at least MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10.
messages: May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Nucleus

7955:ace
gene id: 7955:ace
uniprot id: A0A8N7T834
uniprot id: E7FFA5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 2 Zn(2+) ions per subunit.

7955:rpl27
gene id: 7955:rpl27
uniprot id: B2GP62
uniprot id: Q7ZV82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Component of the large ribosomal subunit.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

7955:tpst1
gene id: 7955:tpst1
uniprot id: A0A0R4IQR2
uniprot id: A0A8M2B4A9
uniprot id: Q9PTE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

7955:spock1
gene id: 7955:spock1
uniprot id: A0A8M9QGI5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:taar20i
gene id: 7955:taar20i
uniprot id: A0A8M1QKH4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:sars
gene id: 7955:sars
uniprot id: Q6DRC0
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:19423848). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:19423848). In the nucleus, binds to the vegfa core promoter and prevents myc binding and transcriptional activation by myc (PubMed:24940000). Thereby inhibits the production of vegfa and sprouting angiogenesis mediated by vegfa (PubMed:19423848, PubMed:19423847, PubMed:22353712, PubMed:24940000).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Morpholino knockdown causes aberrant angiogenesis with excessive intersegmental vessel branching, due to excessive expression of vegfa.
messages: Nucleus

7955:dhx58
gene id: 7955:dhx58
uniprot id: A0A8M9PDC5
uniprot id: A0A8N7XJA9
uniprot id: F1QUY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

7955:fgf9
gene id: 7955:fgf9
uniprot id: A0A8M3B2M7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7955:ctns
gene id: 7955:ctns
uniprot id: Q503T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

7955:slc39a9
gene id: 7955:slc39a9
uniprot id: A9JT08
uniprot id: Q5BL29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

7955:efna1a
gene id: 7955:efna1a
uniprot id: Q6PGZ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ngrn
gene id: 7955:ngrn
uniprot id: Q1JPS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

7955:kdelr2a
gene id: 7955:kdelr2a
uniprot id: Q6PEH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).

7955:ppox
gene id: 7955:ppox
uniprot id: Q32LU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

7955:atraid
gene id: 7955:atraid
uniprot id: A3KNS9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Involved in osteoblast cell differentiation. May play a role in inducing the cell cycle arrest (By similarity).
messages: Nucleus envelope

7955:myo5aa
gene id: 7955:myo5aa
uniprot id: A0A8M2BKY1
uniprot id: A0A8M2BKY7
uniprot id: A0A8M3AJS5
uniprot id: A0A8M3AS48
uniprot id: A0A8M3AV30
uniprot id: A0A8M3B332
uniprot id: A0A8M9P1G5
uniprot id: A0A8M9PAJ4
uniprot id: A0A8M9PPP8
uniprot id: A0A8M9PPQ8
uniprot id: A0A8M9PW04
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:ano9a
gene id: 7955:ano9a
uniprot id: A7MC11
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:zgc:153247
gene id: 7955:zgc:153247
uniprot id: A0A8M9Q7R8
uniprot id: Q0P499
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Mitochondrion matrix

7955:kif13ba
gene id: 7955:kif13ba
uniprot id: A0A8M2BH26
uniprot id: A0A8M2BH53
uniprot id: A0A8M6YTA9
uniprot id: A0A8N7TFU3
uniprot id: X1WFZ0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:lonp2
gene id: 7955:lonp2
uniprot id: Q5PQY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
messages: Belongs to the peptidase S16 family.
messages: Peroxisome matrix

7955:LOC100001620
gene id: 7955:LOC100001620
uniprot id: A0A8M1QLL8
uniprot id: E7EXK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

7955:arl1
gene id: 7955:arl1
uniprot id: B2GR22
uniprot id: Q6DGK1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7955:slc2a9l2
gene id: 7955:slc2a9l2
uniprot id: A0A8M6Z9W0
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:rab4b
gene id: 7955:rab4b
uniprot id: Q68EK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity). Protein transport. Probably involved in vesicular traffic (By similarity).

7955:nr1h3
gene id: 7955:nr1h3
uniprot id: A0A0R4IVP0
uniprot id: A0A8M1N4V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

7955:rars
gene id: 7955:rars
uniprot id: A0A8M6Z3L7
uniprot id: Q7ZVF4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

7955:jupa
gene id: 7955:jupa
uniprot id: Q9PVF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Membrane
messages: desmosome

7955:cacna1aa
gene id: 7955:cacna1aa
uniprot id: A0A8M2BBB9
uniprot id: A0A8M3AR05
uniprot id: A0A8M3AY50
uniprot id: A0A8M3B129
uniprot id: A0A8M3B8D7
uniprot id: A0A8M6Z5Q8
uniprot id: A0A8M9PFQ8
uniprot id: A0A8M9PFU0
uniprot id: A0A8M9PFV0
uniprot id: A0A8M9PFV9
uniprot id: A0A8M9PFW8
uniprot id: A0A8M9PSR1
uniprot id: A0A8M9PSR6
uniprot id: A0A8M9PSS2
uniprot id: A0A8M9PSS9
uniprot id: A0A8M9PSU9
uniprot id: A0A8M9PSV7
uniprot id: A0A8M9PSW2
uniprot id: A0A8M9PYS3
uniprot id: A0A8M9PYT6
uniprot id: A0A8M9PYU4
uniprot id: A0A8M9Q509
uniprot id: A0A8M9Q515
uniprot id: A0A8M9Q554
uniprot id: A0A8M9Q9N8
uniprot id: A0A8M9Q9Q4
uniprot id: A0A8M9Q9T2
uniprot id: A0A8M9Q9V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane

7955:phox2bb
gene id: 7955:phox2bb
uniprot id: Q5I7G4
names: Subcellular Location Annotation
messages: Nucleus

7955:rad54l2
gene id: 7955:rad54l2
uniprot id: A0A8M2BLB3
uniprot id: A0A8N7TAQ7
uniprot id: F1R3L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

7955:taar20r
gene id: 7955:taar20r
uniprot id: A0A8M3B6J5
uniprot id: H0WF96
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:LOC793750
gene id: 7955:LOC793750
uniprot id: A0A0G2KD19
uniprot id: A0A8M3AI81
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:psmd5
gene id: 7955:psmd5
uniprot id: A0A8M1N5A3
uniprot id: F1QU35
uniprot id: Q561Y6
uniprot id: Q6DHD2
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

7955:hlx1
gene id: 7955:hlx1
uniprot id: A0A8M2BHM6
uniprot id: A0A8M3B4D8
uniprot id: Q6NY96
names: Subcellular Location Annotation
messages: Nucleus

7955:si:dkey-92j12.5
gene id: 7955:si:dkey-92j12.5
uniprot id: A0A8M9PKN6
uniprot id: A0A8M9PY69
names: Subcellular Location Annotation
messages: tight junction

7955:bms1
gene id: 7955:bms1
uniprot id: A0A8M1NFD4
uniprot id: E7F349
names: Subcellular Location Annotation
messages: nucleolus

7955:slc5a6b
gene id: 7955:slc5a6b
uniprot id: A9JSZ5
uniprot id: B7ZVD9
uniprot id: Q4V901
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7955:pdcl
gene id: 7955:pdcl
uniprot id: A0A8M1PFM0
uniprot id: F1QTL0
names: Similarity
messages: Belongs to the phosducin family.

7955:gbp4
gene id: 7955:gbp4
uniprot id: A0A8M3B236
uniprot id: Q1MT80
uniprot id: Q5RJ11
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:cdc6
gene id: 7955:cdc6
uniprot id: A8KC19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

7955:si:ch73-157i16.3
gene id: 7955:si:ch73-157i16.3
uniprot id: A0A0R4ISY9
uniprot id: A0A8M3AQM1
uniprot id: A0A8M9PBH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

7955:pafah1b1a
gene id: 7955:pafah1b1a
uniprot id: B2GQS8
uniprot id: Q7T394
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Component of the cytosolic PAF-AH (I) heterotetrameric enzyme, which is composed of PAFAH1B1 (beta), PAFAH1B2 (alpha2) and PAFAH1B3 (alpha1) subunits. The catalytic activity of the enzyme resides in the alpha1 (PAFAH1B3) and alpha2 (PAFAH1B2) subunits, whereas the beta subunit (PAFAH1B1) has regulatory activity. Trimer formation is not essential for the catalytic activity (By similarity). Interacts with dynein, dynactin, nde1 and ndel1.
messages: Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
messages: centrosome
messages: cytoskeleton

7955:slc18a3b
gene id: 7955:slc18a3b
uniprot id: P59845
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Involved in acetylcholine transport into synaptic vesicles.
messages: Membrane

7955:myo6b
gene id: 7955:myo6b
uniprot id: A0A8M1N1X8
uniprot id: A0A8M2B5U0
uniprot id: A0A8M3B2J7
uniprot id: A0A8M9P042
uniprot id: A0A8M9P8V8
uniprot id: E9QFU5
uniprot id: F1R4R9
uniprot id: Q68RJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: clathrin-coated pit
messages: clathrin-coated vesicle
messages: filopodium
messages: microvillus

7955:LOC793909
gene id: 7955:LOC793909
uniprot id: A0A8M2BB35
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:krt4
gene id: 7955:krt4
uniprot id: A0A8M1P5N6
uniprot id: F1QK60
names: Similarity
messages: Belongs to the intermediate filament family.

7955:gpsm1b
gene id: 7955:gpsm1b
uniprot id: Q64HS5
names: Similarity
messages: Belongs to the GPSM family.

7955:spata18
gene id: 7955:spata18
uniprot id: B2GSR0
uniprot id: Q503Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity).
messages: Membrane
messages: Mitochondrion outer membrane

7955:hsd17b1
gene id: 7955:hsd17b1
uniprot id: A0A8M9PPS5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:mul1a
gene id: 7955:mul1a
uniprot id: Q5M7X9
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
messages: Homooligomer.
messages: Mitochondrion outer membrane
messages: The zinc finger domain is required for E3 ligase activity.

7955:tlk2
gene id: 7955:tlk2
uniprot id: Q1ECX4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Monomer (By similarity). May form homodimers; homodimerization may enhance autophosphoylation and enzymatic activity (By similarity). Heterodimer with TLK1 (By similarity).
messages: Nucleus
messages: Phosphorylated (By similarity). Autophosphorylated; phosphorylation promotes the assembly of higher order oligomers and enzymatic activity (By similarity).
messages: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (By similarity). Negative regulator of amino acid starvation-induced autophagy (By similarity).
messages: cytoskeleton
messages: nucleoplasm
messages: perinuclear region

7955:rabggtb
gene id: 7955:rabggtb
uniprot id: B2GQ29
uniprot id: Q4V946
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

7955:si:ch211-243j20.2
gene id: 7955:si:ch211-243j20.2
uniprot id: A0A8M1RKY9
uniprot id: A0A8M3ALR2
uniprot id: A0A8M9PQ05
uniprot id: E9QGS0
names: Similarity
messages: Belongs to the uridine kinase family.

7955:dguok
gene id: 7955:dguok
uniprot id: A0A8M9Q805
uniprot id: A5WUY2
names: Similarity
messages: Belongs to the DCK/DGK family.

7955:ryr2b
gene id: 7955:ryr2b
uniprot id: A0A8M9P9G0
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:tmc6b
gene id: 7955:tmc6b
uniprot id: Q6DH78
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:esr1
gene id: 7955:esr1
uniprot id: A0A8M3B0Y2
uniprot id: P57717
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-beta.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

7955:fam3a
gene id: 7955:fam3a
uniprot id: Q6PBL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

7955:slc17a6a
gene id: 7955:slc17a6a
uniprot id: Q5W8I7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
messages: Cell membrane
messages: Chloride channel activity is allosterically activated by lumenal H(+) and Cl(-) leading to synaptic vesicles acidification. The L-glutamate transport activity is allosterically activated by lumenal H(+) and Cl(-). The allosteric requirement for H(+) efficiently prevents non-vesicular efflux across the plasma membrane. The L-glutamate uniporter activity exhibits a biphasic dependence on chloride concentration.
messages: Expressed in spinal chord.
messages: Membrane
messages: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as a uniporter which transports preferentially L-glutamate but also, phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane therefore affects the proton electrochemical gradient and promotes synaptic vesicles acidification. Moreover, functions as a vesicular K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular L-glutamate uptake. The vesicular H(+)/H(+) antiport activity is electroneutral. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Also involved in the regulation of retinal hyaloid vessel regression during postnatal development (By similarity). May also play a role in the endocrine L-glutamatergic system of other tissues such as pineal gland and pancreas (By similarity).
messages: synaptic vesicle membrane
messages: synaptosome

7955:pnp4a
gene id: 7955:pnp4a
uniprot id: Q7SZW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

7955:dnah12
gene id: 7955:dnah12
uniprot id: A0A8M9P5E8
names: Similarity
messages: Belongs to the dynein heavy chain family.

7955:mycn
gene id: 7955:mycn
uniprot id: Q5GFD4
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
messages: Nucleus

7955:rab14l
gene id: 7955:rab14l
uniprot id: Q6PE19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

7955:prss16
gene id: 7955:prss16
uniprot id: A0A8M1NCQ0
uniprot id: F1Q7G9
names: Similarity
messages: Belongs to the peptidase S28 family.

7955:zgc:153981
gene id: 7955:zgc:153981
uniprot id: A0JMM1
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

7955:pmchl
gene id: 7955:pmchl
uniprot id: B7TWR3
names: Function
messages: Plays a role in skin pigmentation by antagonizing the action of melanotropin alpha. Induces melanin concentration within the melanophores. May participate in the control of the hypothalamo-pituitary adrenal gland axis by inhibiting the release of ACTH.

7955:LOC795662
gene id: 7955:LOC795662
uniprot id: A0A8M1PYS8
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:b3gnt5a
gene id: 7955:b3gnt5a
uniprot id: Q7T3S5
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids.
messages: Expressed in 2 distinct phases during the embryogenesis. The early phase extends from late blastulation to the completion of epiboly, during which the expression occurs in the superficial layer of the embryos. The second phase of expression starts during mid-segmentation and persists until day 3, during which the expression occurs prominently in the developing lens.
messages: Golgi apparatus membrane
messages: Hedgehog signaling is required for expression in embryonic lens.

7955:utp11l
gene id: 7955:utp11l
uniprot id: Q7ZUG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

7955:rpn2
gene id: 7955:rpn2
uniprot id: Q7ZV07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

7955:rab33ba
gene id: 7955:rab33ba
uniprot id: Q498P3
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

7955:flt1
gene id: 7955:flt1
uniprot id: B3DKP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:nup85
gene id: 7955:nup85
uniprot id: Q6DBY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Involved in nephrogenesis (By similarity).
messages: Component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

7955:sod2
gene id: 7955:sod2
uniprot id: Q6P980
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

7955:rpl23
gene id: 7955:rpl23
uniprot id: Q6PC14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

7955:slco5a1a
gene id: 7955:slco5a1a
uniprot id: A0A8M6YW64
uniprot id: E7EYQ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:ugt2b3
gene id: 7955:ugt2b3
uniprot id: D3XD87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:tcea2
gene id: 7955:tcea2
uniprot id: A0A8M1PDT9
uniprot id: F1QTS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

7955:tmc3
gene id: 7955:tmc3
uniprot id: A0A8M9Q8A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

7955:cyp2aa2
gene id: 7955:cyp2aa2
uniprot id: Q05AM2
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:efna3b
gene id: 7955:efna3b
uniprot id: Q68EJ5
uniprot id: Q90YC5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:adprh
gene id: 7955:adprh
uniprot id: B2GP13
uniprot id: Q6DBR3
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

7955:LOC101882029
gene id: 7955:LOC101882029
uniprot id: A0A8M9QBJ2
names: Similarity
messages: Belongs to the helicase family.

7955:tbca
gene id: 7955:tbca
uniprot id: Q7ZV25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

7955:zgc:162872
gene id: 7955:zgc:162872
uniprot id: A0A8M3AHR8
uniprot id: A0A8M9QBT1
uniprot id: A5D6U1
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

7955:LOC100149641
gene id: 7955:LOC100149641
uniprot id: A0A0R4IPT3
uniprot id: A0A8M1QL91
uniprot id: A0A8M3ARL1
uniprot id: A0A8M9PVR6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:gtpbp10
gene id: 7955:gtpbp10
uniprot id: Q6DHF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: May be involved in the ribosome maturation process.
messages: nucleolus

7955:nsfb
gene id: 7955:nsfb
uniprot id: A0A8M6Z3H7
uniprot id: F1QGG3
uniprot id: Q4U0S6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

7955:si:ch211-256m1.8
gene id: 7955:si:ch211-256m1.8
uniprot id: A0A8M1Q1G5
uniprot id: E7FA20
names: Caution
names: Similarity
messages: Belongs to the Ntn-hydrolase family.
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:kcnk1a
gene id: 7955:kcnk1a
uniprot id: A5PLK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

7955:LOC567936
gene id: 7955:LOC567936
uniprot id: A0A8M9P5N0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

7955:slc25a22
gene id: 7955:slc25a22
uniprot id: A0A8M2BJZ1
uniprot id: Q7ZTT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

7955:farsb
gene id: 7955:farsb
uniprot id: Q5RKM6
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

7955:b4galt5
gene id: 7955:b4galt5
uniprot id: Q3YL68
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). Required for proper patterning of the dorsoventral axis during embryogenesis through the regulation of BMP signaling (PubMed:16672343). Plays a role in proteoglycan glycosylation that is required for BMP-dependent specification of the dorsoventral axis (PubMed:16672343).
messages: Expressed by the early epiboly stage and reaches a steady state level of expression by mid-somitogenesis (PubMed:16672343). Shows widespread expression throughout the embryo during the first 24 hours of development, with enhanced expression within several structures at the 20-somite stage (PubMed:16672343).
messages: Golgi apparatus
messages: Golgi stack membrane
messages: Morpholino knockdown results in dorsalized embryos which have ventrally expanded chordin expression and reduced activation of the Bmp-dependent transcription factors smad1/5/8 (PubMed:16672343). Proteoglycans exhibits defective glycosylation and a greatly reduced affinity for bmp2 (PubMed:16672343).

7955:tgm1l2
gene id: 7955:tgm1l2
uniprot id: A0A8M3AVQ9
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

7955:ifitm1
gene id: 7955:ifitm1
uniprot id: A5WUL9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:dlc1
gene id: 7955:dlc1
uniprot id: A0A8M2B6R6
uniprot id: A0A8M6Z677
uniprot id: A0A8M9PK49
uniprot id: E7FBY0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
messages: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.
messages: Membrane
messages: focal adhesion

7955:hrh1
gene id: 7955:hrh1
uniprot id: A0A8M3B6M8
uniprot id: Q195J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:ndrg4
gene id: 7955:ndrg4
uniprot id: A0A0R4ICQ1
uniprot id: A0A8M1NA46
uniprot id: A0A8M2BA26
uniprot id: A0A8M2BA44
uniprot id: A0A8M2BA65
uniprot id: A0A8M2BA87
uniprot id: A0A8M9P6H2
uniprot id: A6XCT1
uniprot id: Q1JPS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

7955:nek5
gene id: 7955:nek5
uniprot id: A0A8M2BJT3
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:mao
gene id: 7955:mao
uniprot id: Q6NSN2
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the flavin monoamine oxidase family.
messages: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:15621520, PubMed:16917825). Preferentially oxidizes serotonin and tyramine (PubMed:15621520, PubMed:16917825). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
messages: Inhibited by both clorgyline (selective MAOA inhibitor) and deprenyl (selective MAOB inhibitor).
messages: Mitochondrion outer membrane
messages: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
messages: Strongest expression in brain and intestine, followed by liver, heart and gill. Little expression in spleen, eye or muscle. In brain, highest activity in noradrenergic and serotonergic cell groups and those of the habenulointerpeduncular pathway; moderate levels in dopaminergic cell clusters.
messages: There appears to be only one form of this enzyme in zebrafish, whereas in mammals two forms (MAOA and MAOB) exist.

7955:nudt1
gene id: 7955:nudt1
uniprot id: Q7ZWC3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Inhibited by TH588.
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:26862114, PubMed:30304478). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:26862114). Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:26862114, PubMed:30304478). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:26862114, PubMed:30304478). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:32144205, PubMed:30304478). Through this antimutagenic activity protects cells from oxidative stress (PubMed:32144205, PubMed:26862114, PubMed:30304478).
messages: cytosol

7955:hbaa2
gene id: 7955:hbaa2
uniprot id: Q6ZM13
names: Similarity
messages: Belongs to the globin family.

7955:tcp11l1
gene id: 7955:tcp11l1
uniprot id: Q58EK1
names: Similarity
messages: Belongs to the TCP11 family.

7955:kcnk10b
gene id: 7955:kcnk10b
uniprot id: A0A286Y8D0
uniprot id: A0A8M2BH55
uniprot id: A0A8M6YVM9
uniprot id: C3VPM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:tmprss4a
gene id: 7955:tmprss4a
uniprot id: A0A8M2B4C3
uniprot id: A0JMD5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pfkmb
gene id: 7955:pfkmb
uniprot id: A0A8M3B3J9
uniprot id: A4QNV1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pif1
gene id: 7955:pif1
uniprot id: Q7ZV90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
messages: Mitochondrion
messages: Monomer.
messages: Nucleus

7955:ddx3a
gene id: 7955:ddx3a
uniprot id: A0A8M1NJ99
uniprot id: A0A8M2BF54
uniprot id: A0A8M2BF62
uniprot id: A0A8M3B2Q5
uniprot id: A0A8M6Z099
uniprot id: A0A8M6Z8G4
uniprot id: A0A8M9QAW2
uniprot id: A0A8M9QFJ5
uniprot id: A0A8M9QJS4
uniprot id: B0S6P6
names: Similarity
messages: Belongs to the DEAD box helicase family.

7955:ntrk2b
gene id: 7955:ntrk2b
uniprot id: A0A0R4ILA2
uniprot id: A0A8M1NUU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:zgc:113223
gene id: 7955:zgc:113223
uniprot id: A0A8M3AXD2
uniprot id: Q5BL96
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:cpne4b
gene id: 7955:cpne4b
uniprot id: E9QJ75
names: Similarity
messages: Belongs to the copine family.

7955:mcoln1b
gene id: 7955:mcoln1b
uniprot id: A0A8N7XJ78
uniprot id: E7FBN6
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

7955:LOC100537363
gene id: 7955:LOC100537363
uniprot id: A0A8M3B0U5
uniprot id: A0A8M3B3S0
uniprot id: E7FEC8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:rpl17
gene id: 7955:rpl17
uniprot id: Q7T1K0
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

7955:clspn
gene id: 7955:clspn
uniprot id: A0A8M9P220
names: Subcellular Location Annotation
messages: Nucleus

7955:fut11
gene id: 7955:fut11
uniprot id: Q08C60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Probable fucosyltransferase.

7955:si:ch211-168b3.1
gene id: 7955:si:ch211-168b3.1
uniprot id: A0A8M2BAD9
uniprot id: A0A8M3AVV3
uniprot id: B8JLA1
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

7955:pik3r2
gene id: 7955:pik3r2
uniprot id: B3DHG9
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

7955:ptges3b
gene id: 7955:ptges3b
uniprot id: Q6IQI3
names: Similarity
messages: Belongs to the p23/wos2 family.

7955:si:dkey-228b2.5
gene id: 7955:si:dkey-228b2.5
uniprot id: E7F1U0
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

7955:tns1a
gene id: 7955:tns1a
uniprot id: A0A8M3ATA5
uniprot id: A0A8M3ATB1
uniprot id: A0A8M3B0D1
uniprot id: A0A8M3B3C3
uniprot id: A0A8M3B3C8
uniprot id: A0A8M3BAB4
uniprot id: A0A8M6YYV2
uniprot id: A0A8N7UR56
names: Similarity
messages: Belongs to the PTEN phosphatase protein family.

7955:ms4a17a.12
gene id: 7955:ms4a17a.12
uniprot id: A0A8M1P8N1
uniprot id: F6NXH3
names: Similarity
messages: Belongs to the MS4A family.

7955:srebf2
gene id: 7955:srebf2
uniprot id: A3KNA7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SREBP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Forms a tight complex with scap, the SCAP-SREBP complex, in the endoplasmic reticulum membrane.
messages: Golgi apparatus membrane
messages: Homodimer; efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein.
messages: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway (By similarity). Activated by mediated cholesterol efflux, transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (PubMed:30705153).
messages: Nucleus
messages: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis.
messages: Processed in the Golgi apparatus, releasing the protein from the membrane (PubMed:30705153). At low cholesterol the SCAP-SREBP complex is recruited into COPII vesicles for export from the endoplasmic reticulum (By similarity). In the Golgi, complex SREBPs are cleaved sequentially by site-1 (mbtps1, S1P) and site-2 (mbtps2, S2P) protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain, releasing the transcription factor from the Golgi membrane (By similarity).

7955:fth1b
gene id: 7955:fth1b
uniprot id: Q66HX7
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

7955:pbx1a
gene id: 7955:pbx1a
uniprot id: A0A8M6Z2J2
uniprot id: Q6NYV6
uniprot id: Q9I9B6
uniprot id: Q9I9B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

7955:ddah1
gene id: 7955:ddah1
uniprot id: Q6NUW4
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

7955:si:ch211-113j14.1
gene id: 7955:si:ch211-113j14.1
uniprot id: A0A8N7USW5
uniprot id: E7F3G8
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:zgc:153409
gene id: 7955:zgc:153409
uniprot id: Q0D294
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:epn2
gene id: 7955:epn2
uniprot id: A0A8M3B8G3
uniprot id: A0A8N7TAM9
uniprot id: E7EYW2
names: Similarity
messages: Belongs to the epsin family.

7955:irf3
gene id: 7955:irf3
uniprot id: A0A8M6Z9B8
uniprot id: B7SEE0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:si:ch73-337l15.2
gene id: 7955:si:ch73-337l15.2
uniprot id: A0A8M6YZD6
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

7955:csnk2b
gene id: 7955:csnk2b
uniprot id: Q1LXD2
uniprot id: Q91398
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Casein kinase II/CK2 is a tetramer composed of two alpha subunits and two beta subunits. The beta subunit dimerization is mediated by zinc ions.
messages: Phosphorylated by alpha subunit.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Participates in Wnt signaling (By similarity).
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

7955:osbpl11
gene id: 7955:osbpl11
uniprot id: A0A8N7UVT3
names: Similarity
messages: Belongs to the OSBP family.

7955:mtap
gene id: 7955:mtap
uniprot id: B2GQM6
uniprot id: Q7ZV22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

7955:kcnk9
gene id: 7955:kcnk9
uniprot id: A0A8M1NHJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane
messages: pH-dependent, voltage-insensitive, background potassium channel protein.

7955:gon4l
gene id: 7955:gon4l
uniprot id: A0A8M1P2G5
uniprot id: F1QI87
names: Subcellular Location Annotation
messages: Nucleus

7955:cyp3c1
gene id: 7955:cyp3c1
uniprot id: Q7ZTW6
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:ssr3
gene id: 7955:ssr3
uniprot id: Q7ZUR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

7955:xirp2b
gene id: 7955:xirp2b
uniprot id: A0A8M9QG77
names: Domain
names: Similarity
messages: Belongs to the Xin family.
messages: Xin repeats bind F-actin.

7955:si:ch211-140l13.3
gene id: 7955:si:ch211-140l13.3
uniprot id: A0A8M6YUD2
names: Similarity
messages: Belongs to the TCP10 family.

7955:sptlc2a
gene id: 7955:sptlc2a
uniprot id: Q503F0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

7955:actr8
gene id: 7955:actr8
uniprot id: P59679
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core (By similarity).
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity).
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity).

7955:ap1m2
gene id: 7955:ap1m2
uniprot id: A0A8M3B038
uniprot id: F1R3L9
uniprot id: Q6TLG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

7955:arf3a
gene id: 7955:arf3a
uniprot id: Q6DHP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

7955:si:dkey-101k6.5
gene id: 7955:si:dkey-101k6.5
uniprot id: A0A8N7TAW3
uniprot id: F1QAH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

7955:ccna1
gene id: 7955:ccna1
uniprot id: F1QGH4
names: Similarity
messages: Belongs to the cyclin family.

7955:trmt5
gene id: 7955:trmt5
uniprot id: A0A8M3AZ45
uniprot id: B8A5G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

7955:neto2b
gene id: 7955:neto2b
uniprot id: A0A8M1RT66
uniprot id: A0A8M2B5G1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:sec11a
gene id: 7955:sec11a
uniprot id: Q6DGR3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:arl6ip4
gene id: 7955:arl6ip4
uniprot id: Q502P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: May be involved in modulating alternative pre-mRNA splicing.
messages: Nucleus speckle
messages: nucleolus

7955:tmem53
gene id: 7955:tmem53
uniprot id: Q6DHN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Ensures normal bone formation, through the negative regulation of bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD proteins.
messages: Nucleus outer membrane

7955:camta2
gene id: 7955:camta2
uniprot id: A0A8M2BID3
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

7955:sod3b
gene id: 7955:sod3b
uniprot id: A0A8M1PYQ3
uniprot id: E9QIM2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

7955:yipf4
gene id: 7955:yipf4
uniprot id: Q6NYF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Involved in the maintenance of the Golgi structure.
messages: cis-Golgi network membrane

7955:tas2r200.1
gene id: 7955:tas2r200.1
uniprot id: Q2MHK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

7955:si:ch211-153b23.4
gene id: 7955:si:ch211-153b23.4
uniprot id: A0A8M1P7C3
uniprot id: F1QWR2
names: Similarity
messages: Belongs to the SUA5 family.

7955:si:ch211-113a14.24
gene id: 7955:si:ch211-113a14.24
uniprot id: A0A8N7TAZ2
uniprot id: E7FAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:atg7
gene id: 7955:atg7
uniprot id: A0A8M9QHT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

7955:si:ch73-281i18.6
gene id: 7955:si:ch73-281i18.6
uniprot id: A0A0R4IQV6
uniprot id: A0A8M1RLP1
names: Similarity
messages: Belongs to the MAP7 family.

7955:zgc:172341
gene id: 7955:zgc:172341
uniprot id: A0A0R4IZE6
uniprot id: A0A8M1P573
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

7955:or115-2
gene id: 7955:or115-2
uniprot id: Q2PRH6
names: Subcellular Location Annotation
messages: Membrane

7955:uts2b
gene id: 7955:uts2b
uniprot id: A0A8M9QLJ3
uniprot id: B3DFZ3
uniprot id: Q7ZZY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted
messages: Urotensin is found in the teleost caudal neurosecretory system. It has a suggested role in osmoregulation and as a corticotropin-releasing factor (By similarity).

7955:cacng1b
gene id: 7955:cacng1b
uniprot id: A0A8N7T8E5
uniprot id: E7F1R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

7955:si:zfos-128g4.1
gene id: 7955:si:zfos-128g4.1
uniprot id: A0A8M1RDG9
names: Subcellular Location Annotation
messages: Nucleus

7955:hmgcra
gene id: 7955:hmgcra
uniprot id: A9JSZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

7955:ubtd2
gene id: 7955:ubtd2
uniprot id: Q6DG43
names: Subcellular Location Annotation
messages: Cytoplasm

7955:atp1b2b
gene id: 7955:atp1b2b
uniprot id: A0A8M2BCP7
uniprot id: Q90Z34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

7955:tcea3
gene id: 7955:tcea3
uniprot id: A0A8M2B4P3
uniprot id: A0A8M3AI93
uniprot id: A0A8M3AI98
uniprot id: A0A8M3AJ90
uniprot id: A0A8M3AJ93
uniprot id: A0A8M3AQQ8
uniprot id: A0A8M3AQR4
uniprot id: A0A8M3ATK5
uniprot id: A0A8M3ATL0
uniprot id: A0A8M3B1T7
uniprot id: A0A8M3B1U0
uniprot id: A0A8M6YSP1
uniprot id: A0A8M6Z1R7
uniprot id: A0A8M9NZ73
uniprot id: A0A8M9NZ77
uniprot id: A0A8M9P7V0
uniprot id: A0A8M9PD11
uniprot id: A0A8M9PD15
uniprot id: A0A8M9PJD8
uniprot id: A0A8M9PMC8
uniprot id: A0A8M9PMD2
uniprot id: Q6P0U5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

7955:jakmip1
gene id: 7955:jakmip1
uniprot id: A0A8M6Z255
uniprot id: A0A8M6Z484
uniprot id: A0A8M6Z9H3
uniprot id: E7FCQ1
names: Similarity
messages: Belongs to the JAKMIP family.

7955:rgs14b
gene id: 7955:rgs14b
uniprot id: A0A8M6YUU5
uniprot id: A0A8M6Z402
uniprot id: E7FGM9
names: Subcellular Location Annotation
messages: dendrite

7955:myh14
gene id: 7955:myh14
uniprot id: A0A8M2B482
uniprot id: A0A8M2B4A6
uniprot id: A0A8M3AHY4
uniprot id: A0A8M3AJ07
uniprot id: A0A8M3AQG4
uniprot id: A0A8M3B1K3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:cyp1d1
gene id: 7955:cyp1d1
uniprot id: Q5U396
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

7955:med25
gene id: 7955:med25
uniprot id: A0A8M2BB42
uniprot id: A0A8M2BBF9
uniprot id: A0A8M3AQJ9
uniprot id: F1R0J2
uniprot id: Q6PEH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 25 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

7955:si:dkey-91f15.1
gene id: 7955:si:dkey-91f15.1
uniprot id: I3ITL1
uniprot id: Q1LYE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:LOC100149931
gene id: 7955:LOC100149931
uniprot id: A0A8M9QC70
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:ctps1a
gene id: 7955:ctps1a
uniprot id: A3QJW5
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

7955:zgc:153760
gene id: 7955:zgc:153760
uniprot id: A0A8M2BGS0
uniprot id: F1QTX6
uniprot id: Q08C20
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

7955:mrpl32
gene id: 7955:mrpl32
uniprot id: A0A8M1NAP7
uniprot id: F1R044
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL32 family.
messages: Cytoplasm

7955:ak4
gene id: 7955:ak4
uniprot id: Q6NUY0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

7955:psmd8
gene id: 7955:psmd8
uniprot id: Q6IQH4
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

7955:si:dkey-23c22.9
gene id: 7955:si:dkey-23c22.9
uniprot id: A0A8M9QIX2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC557301
gene id: 7955:LOC557301
uniprot id: A0A8M1P8C3
uniprot id: F1QZX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

7955:dldh
gene id: 7955:dldh
uniprot id: Q803L1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

7955:akt3a
gene id: 7955:akt3a
uniprot id: A0A8M9PXW5
uniprot id: D9IL79
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

7955:ano3
gene id: 7955:ano3
uniprot id: A0A8M6YW15
uniprot id: A0A8M9PVQ2
uniprot id: A0A8M9PZ95
uniprot id: X1WC49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

7955:abhd16a
gene id: 7955:abhd16a
uniprot id: A0A8M3AQC5
uniprot id: A9JR90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD16 family.
messages: Membrane

7955:twf1b
gene id: 7955:twf1b
uniprot id: Q6DKF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

7955:thrab
gene id: 7955:thrab
uniprot id: A0A8M1QHI1
uniprot id: A0A8M3AYH1
uniprot id: A0A8M3B4P5
uniprot id: U3JAT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

7955:herpud2
gene id: 7955:herpud2
uniprot id: Q6NYI0
names: Function
names: Subcellular Location Annotation
messages: Could be involved in the unfolded protein response (UPR) pathway.
messages: Membrane

7955:cyp7b1
gene id: 7955:cyp7b1
uniprot id: A0A8N7TEP4
uniprot id: E7FEI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

7955:egflam
gene id: 7955:egflam
uniprot id: A0A8M3AZ99
uniprot id: A0A8M3B262
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pus1
gene id: 7955:pus1
uniprot id: A0A8M1N3B0
uniprot id: F1QWW1
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

7955:si:rp71-45k5.4
gene id: 7955:si:rp71-45k5.4
uniprot id: B3DG31
uniprot id: B3DG42
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

7955:ctsll
gene id: 7955:ctsll
uniprot id: A0A8M2BCC0
uniprot id: A2BEM8
uniprot id: Q5XJU5
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:pla2g4f.2
gene id: 7955:pla2g4f.2
uniprot id: A0A8M9P9U1
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

7955:klhl3
gene id: 7955:klhl3
uniprot id: A0A8M9PUC3
uniprot id: A0A8N7T6Q3
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

7955:tymp
gene id: 7955:tymp
uniprot id: A0A8M3B8W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Homodimer.

7955:dnmt3aa
gene id: 7955:dnmt3aa
uniprot id: A0A8M2B825
uniprot id: Q588C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

7955:anxa4
gene id: 7955:anxa4
uniprot id: Q804G7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

7955:atr
gene id: 7955:atr
uniprot id: A0A8N7TEF8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

7955:copz1
gene id: 7955:copz1
uniprot id: Q9IB48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

7955:LOC103909231
gene id: 7955:LOC103909231
uniprot id: A0A8M9PH21
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:lef1
gene id: 7955:lef1
uniprot id: Q9W7C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

7955:hmgn2
gene id: 7955:hmgn2
uniprot id: Q3B732
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

7955:itpr2
gene id: 7955:itpr2
uniprot id: A0A8M9PQQ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

7955:LOC100536887
gene id: 7955:LOC100536887
uniprot id: A0A8M1RTP2
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

7955:slc31a1
gene id: 7955:slc31a1
uniprot id: F1QKH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

7955:glt8d1
gene id: 7955:glt8d1
uniprot id: Q5U3H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Membrane

7955:cmasb
gene id: 7955:cmasb
uniprot id: H9BFW7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) to cytidine 5'-monophosphate 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (CMP-KDN), a substrate required for the addition of sialic acid. Also has weak activity towards N-acetylneuraminic acid (NeuNAc) and N-glycolylneuraminic acid (Neu5Gc).
messages: Cytoplasm
messages: During early stages of development (9-18 hours post fertilization, hpf) has weak and ubiquitous expression. Expression is restricted to brain at 24 hpf. At the hatching stage (48 hpf), detected in heart but not in brain.
messages: Homotetramer.

7955:sh3bgrl2
gene id: 7955:sh3bgrl2
uniprot id: Q6GMK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3BGR family.
messages: Nucleus

7955:mapk4
gene id: 7955:mapk4
uniprot id: B0V360
uniprot id: Q803M9
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

7955:si:dkey-108k21.26
gene id: 7955:si:dkey-108k21.26
uniprot id: E7F5W3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:si:ch211-194e18.2
gene id: 7955:si:ch211-194e18.2
uniprot id: A0A8M1RIN8
names: Similarity
messages: Belongs to the phospholipase D family.

7955:otpa
gene id: 7955:otpa
uniprot id: A0A8M2BHN1
uniprot id: B3DGA5
uniprot id: B3DGA7
uniprot id: F6NUE7
names: Subcellular Location Annotation
messages: Nucleus

7955:cap1
gene id: 7955:cap1
uniprot id: Q6YBS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

7955:naa50
gene id: 7955:naa50
uniprot id: Q6DBY2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. GNAT subfamily.
messages: Cytoplasm
messages: Interacts with naa35.
messages: N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (By similarity). The relevance of N-epsilon-acetyltransferase activity is however unclear (By similarity). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin (By similarity). Essential in embryonic cell proliferation and survival (PubMed:16484612).
messages: Nucleus
messages: Until 48 hpf, highly expressed in developing vascular structures and epidermis. By 48 hpf, becomes restricted to the developing head. By 5 dpf, observed only in the epidermis.

7955:arpc5lb
gene id: 7955:arpc5lb
uniprot id: A0A8M3ASH3
uniprot id: B0S516
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: cytoskeleton

7955:cenpk
gene id: 7955:cenpk
uniprot id: A0A8M1NZ19
uniprot id: A7MBW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

7955:si:ch211-173d10.4
gene id: 7955:si:ch211-173d10.4
uniprot id: A0A8M9QJF6
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

7955:LOC110438163
gene id: 7955:LOC110438163
uniprot id: A0A8M9P824
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

7955:pias1b
gene id: 7955:pias1b
uniprot id: A0A8M9PST5
uniprot id: X1WDM3
names: Similarity
messages: Belongs to the PIAS family.

7955:foxd2
gene id: 7955:foxd2
uniprot id: A0A8M1PB08
uniprot id: B0UXI2
names: Subcellular Location Annotation
messages: Nucleus

7955:tm4sf4
gene id: 7955:tm4sf4
uniprot id: Q6DBQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

7955:pde11al
gene id: 7955:pde11al
uniprot id: A0A8N7TE02
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:prkar1b
gene id: 7955:prkar1b
uniprot id: Q08C49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

7955:bmp7a
gene id: 7955:bmp7a
uniprot id: Q9PTF9
names: Similarity
messages: Belongs to the TGF-beta family.

7955:si:ch211-284b7.3
gene id: 7955:si:ch211-284b7.3
uniprot id: A0A8M9QF42
uniprot id: B3DJJ8
uniprot id: B3DJK3
names: Similarity
messages: Belongs to the UPF0587 family.

7955:dmrt1
gene id: 7955:dmrt1
uniprot id: Q71MM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DMRT family.
messages: Expressed in developing germ cells of both testis and ovary.
messages: Nucleus
messages: Transcription factor that plays a key role in sex determination and differentiation by controlling gonad development and germ cell proliferation. Acts both as a transcription repressor and activator (By similarity).

7955:vasna
gene id: 7955:vasna
uniprot id: A8DZ86
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:154006
gene id: 7955:zgc:154006
uniprot id: Q08BB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

7955:LOC797048
gene id: 7955:LOC797048
uniprot id: A0A8M2BDL6
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

7955:myb
gene id: 7955:myb
uniprot id: A0A8M1P6R3
uniprot id: A0A8M1PBN3
uniprot id: F1QP24
uniprot id: F1QP25
names: Subcellular Location Annotation
messages: Nucleus

7955:grwd1
gene id: 7955:grwd1
uniprot id: Q6DBV2
names: Subcellular Location Annotation
messages: Nucleus

7955:pcbd1
gene id: 7955:pcbd1
uniprot id: Q6PBI6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

7955:dyrk4
gene id: 7955:dyrk4
uniprot id: A0A2R8Q5G9
uniprot id: A0A2R8Q5R9
uniprot id: A0A2R8RWZ6
uniprot id: A0A8M2BLK6
uniprot id: A0A8M3AP26
uniprot id: A0A8M3B761
uniprot id: A0A8M9PYX5
uniprot id: A0A8N7TF79
uniprot id: E7F1S5
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

7955:desi2
gene id: 7955:desi2
uniprot id: Q6DC39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

7955:zgc:77086
gene id: 7955:zgc:77086
uniprot id: Q6NXB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

7955:dhrs13l1
gene id: 7955:dhrs13l1
uniprot id: Q6P001
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:si:ch211-254c8.3
gene id: 7955:si:ch211-254c8.3
uniprot id: A0A8M9PKE5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:wnt4a
gene id: 7955:wnt4a
uniprot id: P47793
uniprot id: Q1RLW9
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Caudal forebrain and neural keel, the floor plate, the gill slit and the developing pronephros.
messages: First detected at the end of gastrulation in the anterior neuroectoderm. Expression increases in the developing brain during somitogenesis but has gone by 36 hours. Expression in the floor plate begins at the 10 somite stage and persists at 72 hours.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development (PubMed:8541205).
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

7955:cpa2
gene id: 7955:cpa2
uniprot id: A0A8M1N162
uniprot id: F1QVD7
uniprot id: Q6DHB8
names: Similarity
messages: Belongs to the peptidase M14 family.

7955:tmem182b
gene id: 7955:tmem182b
uniprot id: A0A8M2BD90
uniprot id: E7F8K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

7955:atpaf2
gene id: 7955:atpaf2
uniprot id: A3KP55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

7955:serpine3
gene id: 7955:serpine3
uniprot id: B0UYL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Probable serine protease inhibitor.
messages: Secreted

7955:nhsl2
gene id: 7955:nhsl2
uniprot id: A0A1L1QZ88
uniprot id: A0A8M1PU99
uniprot id: A0A8M3AUI5
uniprot id: A0A8M3AUJ8
uniprot id: A0A8M3BB95
uniprot id: A0A8M9PQ32
names: Similarity
messages: Belongs to the NHS family.

7955:si:ch211-132b12.1
gene id: 7955:si:ch211-132b12.1
uniprot id: A9JRU4
uniprot id: Q1LVJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:cdc14aa
gene id: 7955:cdc14aa
uniprot id: A0A8M2BAA8
uniprot id: Q7SXZ4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

7955:mrps7
gene id: 7955:mrps7
uniprot id: Q498Z6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

7955:rb1
gene id: 7955:rb1
uniprot id: A0JMQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

7955:mylka
gene id: 7955:mylka
uniprot id: A0A8M3AVR0
uniprot id: A0A8M3BC88
uniprot id: A0A8M6Z0Z3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

7955:efhc1
gene id: 7955:efhc1
uniprot id: Q7T2F1
names: Subcellular Location Annotation
messages: cilium axoneme

7955:ccdc167
gene id: 7955:ccdc167
uniprot id: Q5RHZ2
names: Subcellular Location Annotation
messages: Membrane

7955:mtnr1aa
gene id: 7955:mtnr1aa
uniprot id: B2GP09
uniprot id: P51046
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: By cocaine, which increases the levels of day-time expression.
messages: Cell membrane
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).
messages: High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.
messages: Membrane

7955:LOC100329477
gene id: 7955:LOC100329477
uniprot id: A0A8M9Q4D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

7955:cyr61l2
gene id: 7955:cyr61l2
uniprot id: A0A0R4IXA2
uniprot id: A0A8M1NBV7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:cpne5b
gene id: 7955:cpne5b
uniprot id: A0A286Y928
uniprot id: A0A8M6Z1M6
uniprot id: Q7T296
names: Similarity
messages: Belongs to the copine family.

7955:mrps2
gene id: 7955:mrps2
uniprot id: A1L2B4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

7955:elovl6l
gene id: 7955:elovl6l
uniprot id: Q802X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7955:syn2b
gene id: 7955:syn2b
uniprot id: A0A0R4IJU5
uniprot id: A0A8M1P900
names: Similarity
messages: Belongs to the synapsin family.

7955:sesn1
gene id: 7955:sesn1
uniprot id: A0A8M2B7J2
uniprot id: A0A8M2B7J7
uniprot id: A0A8M2B7S8
uniprot id: Q5RGN4
uniprot id: Q6DG05
uniprot id: U3JAG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

7955:fah
gene id: 7955:fah
uniprot id: A0A8M9PNK3
uniprot id: Q803S0
names: Similarity
messages: Belongs to the FAH family.

7955:rtn4ip1
gene id: 7955:rtn4ip1
uniprot id: Q7T3C7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: Mitochondrion outer membrane
messages: Plays a role in the regulation of retinal ganglion cell (RGC) maturation, neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267). Appears to be a potent inhibitor of regeneration following spinal cord injury (By similarity).

7955:smo
gene id: 7955:smo
uniprot id: A0A8N1Z117
uniprot id: Q5RH73
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:si:ch211-241j12.3
gene id: 7955:si:ch211-241j12.3
uniprot id: A0A2R8RWI7
uniprot id: A0A8M1N7J7
uniprot id: A0A8M6Z2P8
names: Similarity
messages: Belongs to the actin family.

7955:aqp4
gene id: 7955:aqp4
uniprot id: A0A2R8Q5A8
uniprot id: A0A8M3AW39
uniprot id: Q6AZD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

7955:prpf4
gene id: 7955:prpf4
uniprot id: Q6PH45
names: Subcellular Location Annotation
messages: Nucleus speckle

7955:sfrp5
gene id: 7955:sfrp5
uniprot id: Q6YNR8
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:namptb
gene id: 7955:namptb
uniprot id: A0A8M1PFF2
uniprot id: F1RDZ8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

7955:xpc
gene id: 7955:xpc
uniprot id: A0A8M1NA71
uniprot id: A0A8M9PQU6
uniprot id: Q1LVE4
names: Similarity
messages: Belongs to the XPC family.

7955:LOC101886664
gene id: 7955:LOC101886664
uniprot id: A0A8M3B7Y5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:spout1
gene id: 7955:spout1
uniprot id: Q66ID3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

7955:si:dkey-236e20.3
gene id: 7955:si:dkey-236e20.3
uniprot id: Q1L873
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:eef2kmt
gene id: 7955:eef2kmt
uniprot id: A0A8M3B8A5
uniprot id: Q5XJN3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

7955:cyb5d2
gene id: 7955:cyb5d2
uniprot id: A2CES0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Heme-binding protein which promotes neuronal but not astrocyte differentiation.
messages: Secreted
messages: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 90 and 114.

7955:eef1a1a
gene id: 7955:eef1a1a
uniprot id: Q6P969
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

7955:si:ch73-281k2.5
gene id: 7955:si:ch73-281k2.5
uniprot id: A0A0R4IN59
uniprot id: A0A8M3B4U9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:mfap1
gene id: 7955:mfap1
uniprot id: Q7ZTX7
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

7955:mfi2
gene id: 7955:mfi2
uniprot id: A0A8M3B3G9
uniprot id: A0A8N7TE96
uniprot id: E7F2E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.

7955:or133-10
gene id: 7955:or133-10
uniprot id: A0A8M3AWW2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:jarid2b
gene id: 7955:jarid2b
uniprot id: Q1LVC2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the PRC2 complex.
messages: Belongs to the JARID2 family.
messages: Nucleus
messages: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development (By similarity).
messages: The ARID domain is required to target the PRC2 complex to its target genes.

7955:fam46c
gene id: 7955:fam46c
uniprot id: Q7ZUP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TENT family.
messages: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression.
messages: Cytoplasm
messages: Nucleus
messages: centrosome

7955:chd1
gene id: 7955:chd1
uniprot id: A0A0R4IAE4
uniprot id: A0A0R4IC05
uniprot id: A0A8M3B320
uniprot id: A0A8M3B604
uniprot id: A0A8N7UZ13
names: Subcellular Location Annotation
messages: Nucleus

7955:borcs7
gene id: 7955:borcs7
uniprot id: Q4V8S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.
messages: Belongs to the BORCS7 family.
messages: Lysosome membrane

7955:ihha
gene id: 7955:ihha
uniprot id: A3KNS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

7955:tubd1
gene id: 7955:tubd1
uniprot id: A0A8M2B3Q4
uniprot id: A0A8M9QBY1
uniprot id: Q6IQ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

7955:sorcs3
gene id: 7955:sorcs3
uniprot id: A0A8M9Q0Q0
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

7955:tnfrsf9b
gene id: 7955:tnfrsf9b
uniprot id: A0A0R4IT02
uniprot id: A0A8M1P3D0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ccnb2
gene id: 7955:ccnb2
uniprot id: A0A8M2BG43
uniprot id: Q7ZVA8
names: Similarity
messages: Belongs to the cyclin family.

7955:he2
gene id: 7955:he2
uniprot id: A4VCG4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:gabarapl2
gene id: 7955:gabarapl2
uniprot id: Q6DHH0
uniprot id: Q6TH05
names: Similarity
messages: Belongs to the ATG8 family.

7955:eef1a1b
gene id: 7955:eef1a1b
uniprot id: Q568F0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

7955:glb1
gene id: 7955:glb1
uniprot id: A0A8M2B6W2
uniprot id: Q56A50
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

7955:cmtm4
gene id: 7955:cmtm4
uniprot id: Q6DGM6
names: Subcellular Location Annotation
messages: Membrane

7955:LOC556106
gene id: 7955:LOC556106
uniprot id: E7F870
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

7955:serpinb1l4
gene id: 7955:serpinb1l4
uniprot id: A0A8M1PAG1
uniprot id: F8W475
names: Similarity
messages: Belongs to the serpin family.

7955:bmp10
gene id: 7955:bmp10
uniprot id: A2BGK2
uniprot id: B3DKI5
names: Similarity
messages: Belongs to the TGF-beta family.

7955:p2rx4b
gene id: 7955:p2rx4b
uniprot id: A0A8M9QDM4
uniprot id: B3DHI3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

7955:sycp2l
gene id: 7955:sycp2l
uniprot id: A0A8M6YVU8
uniprot id: A0A8M6YYB4
uniprot id: A0A8M6Z4W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYCP2 family.
messages: Nucleus

7955:cd44b
gene id: 7955:cd44b
uniprot id: A0A8M3APC4
uniprot id: A0A8M6YW61
uniprot id: A0A8M6YYL8
uniprot id: A0A8M6Z4J5
uniprot id: A0A8M6Z569
uniprot id: X1WBP3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

7955:tmem144b
gene id: 7955:tmem144b
uniprot id: Q5XJ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

7955:derl1
gene id: 7955:derl1
uniprot id: A0A8M1PJE6
uniprot id: F1Q4W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

7955:zap70
gene id: 7955:zap70
uniprot id: Q503P3
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

7955:tonsl
gene id: 7955:tonsl
uniprot id: A9JR78
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tonsoku family.
messages: Chromosome
messages: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, TONSL acts as histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones.
messages: Component of the MMS22L-TONSL complex. Binds histones, with a strong preference for histone H3.1 (histones H3.1 and H3-4/H3.1t).
messages: Cytoplasm
messages: Nucleus
messages: Tonsl deficiency causes growth deficits, vertebral abnormalities, reduced neutrophil numbers, and death at early stages of larvae development.

7955:abhd14a
gene id: 7955:abhd14a
uniprot id: Q1LV46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. ABHD14 family.
messages: Cytoplasm
messages: Membrane
messages: Possible role in granule neuron development.

7955:vgll3
gene id: 7955:vgll3
uniprot id: A0A8M9PSN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

7955:si:ch211-151p13.8
gene id: 7955:si:ch211-151p13.8
uniprot id: E7F7K9
names: Similarity
messages: Belongs to the UPF0687 family.

7955:gorab
gene id: 7955:gorab
uniprot id: A0A8M2B7I8
uniprot id: Q7T320
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GORAB family.
messages: Cytoplasm
messages: Golgi apparatus

7955:hsd3b1
gene id: 7955:hsd3b1
uniprot id: A0A8N7TFA8
uniprot id: F1QSA2
names: Similarity
messages: Belongs to the 3-beta-HSD family.

7955:kcnj11l
gene id: 7955:kcnj11l
uniprot id: Q32PS3
uniprot id: Q5R205
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:psmd7
gene id: 7955:psmd7
uniprot id: Q7ZYX7
names: Similarity
messages: Belongs to the peptidase M67A family.

7955:meis2a
gene id: 7955:meis2a
uniprot id: A0A0H2UKR5
uniprot id: A0A8M3AJB0
uniprot id: A0A8M3AK57
uniprot id: A0A8M3AK61
uniprot id: A0A8M3ARP6
uniprot id: A0A8M3AUL9
uniprot id: A0A8M3AUM6
uniprot id: A0A8M3B2P5
uniprot id: Q6PHK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

7955:glra3
gene id: 7955:glra3
uniprot id: A0A8M9Q7Y2
uniprot id: Q90W14
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

7955:tead1b
gene id: 7955:tead1b
uniprot id: A0A8M3AUN1
uniprot id: A0A8M3AUR1
uniprot id: A0A8M3B1M0
uniprot id: A0A8M3B4I0
uniprot id: A0A8M3B4I3
uniprot id: A0A8M3BBE2
uniprot id: A0A8M3BBE7
uniprot id: A0A8M9PQ99
uniprot id: A0A8M9Q920
uniprot id: A0A8M9QD63
uniprot id: A0A8M9QI50
names: Subcellular Location Annotation
messages: Nucleus

7955:xkrx
gene id: 7955:xkrx
uniprot id: Q5U3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

7955:tmx2a
gene id: 7955:tmx2a
uniprot id: A0A8M6Z9U1
uniprot id: A8WG88
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane
messages: Monomer. Homodimer; disulfide-linked. Occurs in both reduced and oxidized monomeric form. Oxidative conditions increase homodimerization.
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
messages: The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.

7955:crb2a
gene id: 7955:crb2a
uniprot id: Q1A5L2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:dph3
gene id: 7955:dph3
uniprot id: Q502H4
names: Similarity
messages: Belongs to the DPH3 family.

7955:gramd1ba
gene id: 7955:gramd1ba
uniprot id: A0A8M3AX65
uniprot id: A0A8M3BDB3
uniprot id: A0A8M9Q098
uniprot id: A0A8M9Q6Q6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:LOC101883600
gene id: 7955:LOC101883600
uniprot id: A0A8M2BJQ7
names: Subcellular Location Annotation
messages: Membrane

7955:mcm10
gene id: 7955:mcm10
uniprot id: B7ZV42
uniprot id: Q5RHY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).
messages: Belongs to the MCM10 family.
messages: Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.
messages: Nucleus
messages: Self-associates.
messages: The N-terminal domain mediates homodimerization.

7955:cx32.3
gene id: 7955:cx32.3
uniprot id: Q7T2D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:lrp2bp
gene id: 7955:lrp2bp
uniprot id: A5PLI4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May act as an adapter that regulates LRP2 function.

7955:pdik1l
gene id: 7955:pdik1l
uniprot id: A5WV55
uniprot id: Q32PP3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Glu-37 is present instead of the conserved Lys which is expected to be an active site residue. Lys-38 may fulfill that role.
messages: Nucleus

7955:dip2bb
gene id: 7955:dip2bb
uniprot id: A0A8M3BAI5
uniprot id: A0A8M9P9C1
uniprot id: A0A8M9PRJ7
uniprot id: A0A8M9PYS4
uniprot id: A0A8M9Q253
names: Similarity
messages: Belongs to the DIP2 family.

7955:ero1a
gene id: 7955:ero1a
uniprot id: A0A0H2UJM0
uniprot id: A0A8M1PEC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

7955:banp
gene id: 7955:banp
uniprot id: A0A8M2B767
uniprot id: Q502P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BANP/SMAR1 family.
messages: DNA-binding protein which may repress cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity).
messages: Nucleus

7955:LOC108180715
gene id: 7955:LOC108180715
uniprot id: A0A8M9PIH6
names: Similarity
messages: Belongs to the cullin family.

7955:LOC562831
gene id: 7955:LOC562831
uniprot id: A0A2R8QAF5
uniprot id: A0A8M3AZI4
uniprot id: A0A8M9PYV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:olfcw1
gene id: 7955:olfcw1
uniprot id: Q501X9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:anxa1c
gene id: 7955:anxa1c
uniprot id: Q804H0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: cilium

7955:LOC101883602
gene id: 7955:LOC101883602
uniprot id: A0A8M2BK08
uniprot id: A0A8M3AX05
uniprot id: A0A8M3AX26
uniprot id: A0A8M3BD84
names: Subcellular Location Annotation
messages: Membrane

7955:igfbp5a
gene id: 7955:igfbp5a
uniprot id: A5PLA3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:ablim1b
gene id: 7955:ablim1b
uniprot id: A0A8M3AY85
uniprot id: A0A8M3AY90
uniprot id: A0A8M3AYB1
uniprot id: A0A8M3B4J8
uniprot id: A0A8M3B7C9
uniprot id: A0A8M3B7D2
uniprot id: A0A8M3BE44
uniprot id: A0A8M3BE46
uniprot id: A0A8M6Z1B0
uniprot id: A0A8M6Z9B1
uniprot id: A0A8M9PW77
uniprot id: A0A8M9PW83
uniprot id: A0A8M9PW94
uniprot id: A0A8M9PWA0
uniprot id: A0A8M9PWA8
uniprot id: A0A8M9PWB3
uniprot id: A0A8M9Q8B8
uniprot id: A0A8M9Q8C2
uniprot id: A0A8M9Q8C5
uniprot id: A0A8M9Q8C9
uniprot id: A0A8M9Q8D3
uniprot id: A0A8M9Q8D8
uniprot id: A0A8M9Q8E2
uniprot id: A0A8M9Q8E7
uniprot id: A0A8M9QE78
uniprot id: A0A8M9QE81
uniprot id: A0A8M9QE86
uniprot id: A0A8M9QE90
uniprot id: A0A8M9QE96
uniprot id: A0A8M9QEA1
uniprot id: A0A8M9QIN0
uniprot id: A0A8M9QIN3
uniprot id: A0A8M9QIN6
uniprot id: A0A8M9QIP0
uniprot id: A0A8M9QIP3
uniprot id: A0A8M9QIQ0
uniprot id: A0A8M9QMG0
uniprot id: A0A8M9QMG5
uniprot id: A0A8M9QMG7
uniprot id: A0A8M9QMH2
uniprot id: A0A8M9QMH6
uniprot id: A0A8M9QMH8
names: Subcellular Location Annotation
messages: Cytoplasm

7955:LOC103910196
gene id: 7955:LOC103910196
uniprot id: A0A8M6Z503
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

7955:mif
gene id: 7955:mif
uniprot id: Q0ZBR7
names: Similarity
messages: Belongs to the MIF family.

7955:ube2v2
gene id: 7955:ube2v2
uniprot id: Q6PEH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has no ubiquitin ligase activity on its own. The ube2v2/ube2n heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).
messages: Heterodimer with ube2n.

7955:b3galt1a
gene id: 7955:b3galt1a
uniprot id: A0A8M6Z7E1
uniprot id: E7EXJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:myct1a
gene id: 7955:myct1a
uniprot id: Q5SNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYCT1 family.
messages: Nucleus

7955:dharma
gene id: 7955:dharma
uniprot id: O93236
names: Subcellular Location Annotation
messages: Nucleus

7955:cox10
gene id: 7955:cox10
uniprot id: A0A8M1NVI9
uniprot id: F1QL30
uniprot id: Q08C12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

7955:LOC103909390
gene id: 7955:LOC103909390
uniprot id: A0A8M9QH17
names: Subcellular Location Annotation
messages: Membrane

7955:LOC792447
gene id: 7955:LOC792447
uniprot id: A0A2R8PWT4
uniprot id: A0A8M3AQX3
uniprot id: A0A8M9PZP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

7955:prps1a
gene id: 7955:prps1a
uniprot id: A0A8M3AS85
uniprot id: A0A8M3B9F9
uniprot id: A0A8M9QDH9
uniprot id: Q4KME9
uniprot id: Q6NYR9
uniprot id: Q7ZW39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

7955:unc93b1
gene id: 7955:unc93b1
uniprot id: F1QYA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

7955:sntb1
gene id: 7955:sntb1
uniprot id: B2GRW8
uniprot id: Q6GMG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

7955:zgc:123238
gene id: 7955:zgc:123238
uniprot id: Q3B7P4
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

7955:rrm1
gene id: 7955:rrm1
uniprot id: A0A8M1PC36
uniprot id: F1R2K9
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

7955:smim12
gene id: 7955:smim12
uniprot id: Q5BKW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM12 family.
messages: Membrane

7955:mul1b
gene id: 7955:mul1b
uniprot id: A5PLF8
uniprot id: F1QJY3
names: Subcellular Location Annotation
messages: Membrane

7955:ivd
gene id: 7955:ivd
uniprot id: Q7ZTH9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7955:mocos
gene id: 7955:mocos
uniprot id: A0A8M1N4Y2
uniprot id: A0A8M3B7X2
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

7955:rdh8b
gene id: 7955:rdh8b
uniprot id: A0A8M1PF16
uniprot id: F1QT23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

7955:map3k10
gene id: 7955:map3k10
uniprot id: A0A8N7TB13
uniprot id: F1Q5J2
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

7955:psmc1b
gene id: 7955:psmc1b
uniprot id: Q6IQ72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

7955:pgm2
gene id: 7955:pgm2
uniprot id: Q6NYE3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

7955:serpina1l
gene id: 7955:serpina1l
uniprot id: A0A8N7V0N1
names: Similarity
messages: Belongs to the serpin family.

7955:gb:cr929477
gene id: 7955:gb:cr929477
uniprot id: A0A8M3B256
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

7955:tfap2a
gene id: 7955:tfap2a
uniprot id: A0A2R8QRQ5
uniprot id: A0A8M1P295
uniprot id: A0A8M1PAC7
uniprot id: A0A8M2B9E2
uniprot id: F1QUT4
uniprot id: Q6NYI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

7955:tspan2b
gene id: 7955:tspan2b
uniprot id: A0A8M2B8Q2
uniprot id: E9QBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

7955:actr2a
gene id: 7955:actr2a
uniprot id: A0A8M9PGP1
uniprot id: Q7SXW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
messages: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
messages: Belongs to the actin family. ARP2 subfamily.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of actr2/arp2, actr3/arp3, arpc1b, arpc2, arpc3, arpc4 and arpc5.
messages: Component of the Arp2/3 complex.
messages: Nucleus
messages: cytoskeleton

7955:fam208b
gene id: 7955:fam208b
uniprot id: A0A1L1QZC7
uniprot id: A0A8M2BE90
uniprot id: A0A8M3AUY9
uniprot id: A0A8M3BBL9
names: Similarity
messages: Belongs to the TASOR family.

7955:gdf9
gene id: 7955:gdf9
uniprot id: Q5MD90
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

7955:otud7b
gene id: 7955:otud7b
uniprot id: A0A8M2B4S2
uniprot id: A0A8M2B4T1
uniprot id: A0A8M2B591
uniprot id: A0A8M9NZE1
uniprot id: A0JMB7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:hsdl2
gene id: 7955:hsdl2
uniprot id: Q6P5L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Has apparently no steroid dehydrogenase activity.
messages: Peroxisome

7955:lyplal1
gene id: 7955:lyplal1
uniprot id: A0A8M6YV78
uniprot id: Q5CZM6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

7955:sema4ab
gene id: 7955:sema4ab
uniprot id: A0A8M2BHW0
uniprot id: A0A8N7UW38
uniprot id: F1R501
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:trmt61a
gene id: 7955:trmt61a
uniprot id: Q6DI31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

7955:ndufs1
gene id: 7955:ndufs1
uniprot id: Q5RKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

7955:bloc1s5
gene id: 7955:bloc1s5
uniprot id: Q4V9F5
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

7955:adamts10
gene id: 7955:adamts10
uniprot id: A0A8M1NG56
uniprot id: A0A8M3AV42
uniprot id: B0S6F1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:lyrm4
gene id: 7955:lyrm4
uniprot id: A0A2R8Q8D7
uniprot id: A0A8M6YWE3
uniprot id: B8JLQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Mitochondrion
messages: Nucleus
messages: Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.

7955:tada1
gene id: 7955:tada1
uniprot id: Q6NWA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TADA1 family.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

7955:cxcl11.6
gene id: 7955:cxcl11.6
uniprot id: A0A8M9PYE3
uniprot id: B0R191
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Ligand for cxcr3.2. Chemotactic for macrophages.
messages: Secreted
messages: Up-regulated in response to bacterial infection by S.typhimurium or M.marinum.

7955:ppfibp1b
gene id: 7955:ppfibp1b
uniprot id: A0A8M1N9Q9
uniprot id: A0A8M3B2U3
uniprot id: A0A8M9PA39
uniprot id: A0A8M9PFH0
uniprot id: A0A8M9PQ97
uniprot id: B7ZVC4
uniprot id: Q1LUM4
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

7955:trnau1apb
gene id: 7955:trnau1apb
uniprot id: A0A8M1N7C7
uniprot id: A0A8M9Q082
uniprot id: F1QXG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Nucleus

7955:nr2f5
gene id: 7955:nr2f5
uniprot id: B3DI15
uniprot id: Q06726
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus
messages: Putative receptor that is required in photoreceptor cells precursors during eye development.

7955:msrb2
gene id: 7955:msrb2
uniprot id: G1K2G0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

7955:drd6b
gene id: 7955:drd6b
uniprot id: A0A8M1PZI1
uniprot id: F1QPK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:sned1
gene id: 7955:sned1
uniprot id: A0A8M3BAE4
uniprot id: A0A8M6YZQ4
uniprot id: E7F2S5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:zgc:194221
gene id: 7955:zgc:194221
uniprot id: B3DHE2
uniprot id: B3DHE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Nucleus

7955:med14
gene id: 7955:med14
uniprot id: A0A8M1PFL7
uniprot id: A0A8M2BFA2
uniprot id: A0A8M2BFA7
uniprot id: E9QDB5
uniprot id: F1R9C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7955:per2
gene id: 7955:per2
uniprot id: A0A8M9PS01
uniprot id: A0A8M9QFB2
uniprot id: F1QUT1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:ptger1c
gene id: 7955:ptger1c
uniprot id: D0EXE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:stk38b
gene id: 7955:stk38b
uniprot id: A0A8M6YV57
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:sdr16c5a
gene id: 7955:sdr16c5a
uniprot id: A0A8M1PI82
uniprot id: A8E7S3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:mcm3
gene id: 7955:mcm3
uniprot id: A0A8N7V092
uniprot id: Q5RIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

7955:tmem258
gene id: 7955:tmem258
uniprot id: Q6PBS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

7955:CYTB
gene id: 7955:CYTB
uniprot id: A0A0A0VDB5
uniprot id: Q9MIX8
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins.
messages: The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.

7955:si:ch211-68a17.7
gene id: 7955:si:ch211-68a17.7
uniprot id: E7EXZ6
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A complete loss of mitochondrial respiratory chain complex III resulting in severe growth retardation, lactic acidosis and early death.
messages: Essential for mitochondrial respiratory chain complex III (CIII) assembly and stability (PubMed:32161263). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity).
messages: Highly expressed in skeletal and cardiac muscle (at protein level).
messages: Mitochondrion inner membrane

7955:psen1
gene id: 7955:psen1
uniprot id: A0A8M2BHL3
uniprot id: F1Q8Y6
uniprot id: F8W381
uniprot id: Q9W6T7
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10521267). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity).
messages: Cell membrane
messages: Cleaved, probably through autocleavage.
messages: Cytoplasmic granule
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically. Ubiquitously expressed during embryogenesis.
messages: Golgi apparatus membrane
messages: Heterogeneous proteolytic processing generates N-terminal (NTF) and C-terminal (CTF) fragments of approximately 35 and 20 kDa, respectively. During apoptosis, the C-terminal fragment (CTF) is further cleaved by a caspase.
messages: Homodimer.
messages: Homodimer. The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Substrates, such as NOTCH1 and APP peptides, are bound between PSEN1 transmembrane domains and via the first lumenal loop and the cytoplasmic loop between the sixth and seventh transmembrane domains. Substrate binding causes a conformation change and formation of an intermolecular antiparallel beta-sheet between PSEN1 and its substrates.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

7955:ctbp1
gene id: 7955:ctbp1
uniprot id: A0A8M2BKF1
uniprot id: Q7ZU55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

7955:dexi
gene id: 7955:dexi
uniprot id: Q6AXJ3
names: Similarity
messages: Belongs to the DEXI family.

7955:itprip
gene id: 7955:itprip
uniprot id: Q567X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Cell membrane
messages: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
messages: Nucleus outer membrane

7955:gtf2h4
gene id: 7955:gtf2h4
uniprot id: Q6P2T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

7955:c7a
gene id: 7955:c7a
uniprot id: A0A8M3AV96
uniprot id: A0A8N7UT40
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:sstr1b
gene id: 7955:sstr1b
uniprot id: A0A1D5NSQ4
uniprot id: A0A455LLX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:LOC100334365
gene id: 7955:LOC100334365
uniprot id: A0A8M1RDA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:senp8
gene id: 7955:senp8
uniprot id: Q08CI6
names: Similarity
messages: Belongs to the peptidase C48 family.

7955:slc10a4
gene id: 7955:slc10a4
uniprot id: A0A8M1N9C8
uniprot id: A0A8M1PA55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

7955:muc5d
gene id: 7955:muc5d
uniprot id: A0A8M9P6N4
uniprot id: A0A8M9PVA3
uniprot id: A0A8M9PYQ3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:rgs12a
gene id: 7955:rgs12a
uniprot id: A0A8M2BJJ9
uniprot id: A0A8M3B127
uniprot id: A0A8M3B3Z7
uniprot id: A0A8N7URF2
uniprot id: F1QV08
names: Subcellular Location Annotation
messages: Cytoplasm
messages: dendrite

7955:cltcl1
gene id: 7955:cltcl1
uniprot id: A0A8M9QF30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

7955:faslg
gene id: 7955:faslg
uniprot id: Q0PKX7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:esr2a
gene id: 7955:esr2a
uniprot id: Q7ZU32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

7955:mtpn
gene id: 7955:mtpn
uniprot id: Q7T2B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myotrophin family.
messages: Cytoplasm
messages: Nucleus
messages: Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity).
messages: perinuclear region

7955:large
gene id: 7955:large
uniprot id: Q66PG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (By similarity). Plays a key role in skeletal muscle function and regeneration (By similarity).
messages: Binds 2 Mn(2+) ions per subunit. The xylosyltransferase part binds one Mn(2+) and the beta-1,3-glucuronyltransferase part binds one Mn(2+).
messages: Golgi apparatus membrane
messages: In the C-terminal section; belongs to the glycosyltransferase 49 family.
messages: In the N-terminal section; belongs to the glycosyltransferase 8 family.

7955:si:ch211-146m13.3
gene id: 7955:si:ch211-146m13.3
uniprot id: A0A8N7T7Q7
uniprot id: E7F2R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:serpina7
gene id: 7955:serpina7
uniprot id: A0A8M1NFY0
uniprot id: A0A8M9QE74
uniprot id: F8W5C3
names: Similarity
messages: Belongs to the serpin family.

7955:ss18l2
gene id: 7955:ss18l2
uniprot id: Q567E9
names: Similarity
messages: Belongs to the SS18 family.

7955:ablim3
gene id: 7955:ablim3
uniprot id: A0A0R4IXJ5
uniprot id: A0A8M2BKN0
uniprot id: A0A8M2BL22
uniprot id: A0A8M9QB40
uniprot id: A0A8M9QGG2
uniprot id: A0A8M9QP71
uniprot id: A1L269
uniprot id: B7ZVF6
uniprot id: H0WEN9
names: Subcellular Location Annotation
messages: Cytoplasm

7955:lbx1a
gene id: 7955:lbx1a
uniprot id: Q6ZM39
names: Subcellular Location Annotation
messages: Nucleus

7955:add3a
gene id: 7955:add3a
uniprot id: A0A2R8Q5P5
uniprot id: A0A2R8QBF8
uniprot id: A0A8M2B8P9
uniprot id: A0A8M6YXA3
uniprot id: A0A8M6Z434
uniprot id: Q1LUP1
uniprot id: Q1LUP2
uniprot id: Q7ZUA1
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

7955:LOC110437880
gene id: 7955:LOC110437880
uniprot id: A0A8M9PT95
names: Similarity
messages: Belongs to the RRP1 family.

7955:primpol
gene id: 7955:primpol
uniprot id: Q32PL8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Can act both with Mn(2+) and Mg(2+) as cofactor in vitro, but Mn(2+) is the preferred cofactor in vivo.
messages: Chromosome
messages: DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (By similarity). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as UV lesions, R-loops and G-quadruplexes, to allow DNA replication to continue (By similarity). Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion. Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase. Also required for reinitiating stalled forks after ultraviolet (UV) damage during nuclear DNA replication. Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides. In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity).
messages: Mitochondrion matrix
messages: Nucleus
messages: The presence of an Asp-Aaa-Glu (DxE) motif in the metal-binding active site favors the use of Mn(2+) ions to achieve optimal incoming nucleotide stabilization, especially required during primer synthesis. Glu-119 is required to stabilize the incoming nucleotide at the 3'-site.
messages: The zinc knuckle motif binds zinc and is required for the DNA primase activity. It facilitates the binding and selection of the 5'-nucleotide of the newly synthesized primer and the recognition of preferred initiation sites.

7955:kpnb3
gene id: 7955:kpnb3
uniprot id: A0A8M3AWW3
uniprot id: A0A8N7UZ95
uniprot id: B8JHR9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

7955:avpr2aa
gene id: 7955:avpr2aa
uniprot id: A0A8M1PZX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:pdcd4b
gene id: 7955:pdcd4b
uniprot id: Q1L8Y5
uniprot id: Q7ZVK1
names: Similarity
messages: Belongs to the PDCD4 family.

7955:il12ba
gene id: 7955:il12ba
uniprot id: Q6F3Q9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-12B family.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

7955:arl8
gene id: 7955:arl8
uniprot id: Q7SZE7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

7955:gusb
gene id: 7955:gusb
uniprot id: A0A8M3AZ75
uniprot id: F1QGS9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Homotetramer.
messages: Inhibited by L-aspartic acid.
messages: Lysosome
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

7955:rhpn2
gene id: 7955:rhpn2
uniprot id: A0A8M2BG90
uniprot id: Q6TNR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RHPN family.
messages: Binds specifically to GTP-Rho.
messages: Cytoplasm
messages: Interacts with RhoA.

7955:cryl1
gene id: 7955:cryl1
uniprot id: Q0V973
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

7955:dcp2
gene id: 7955:dcp2
uniprot id: Q803B9
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

7955:foxn2b
gene id: 7955:foxn2b
uniprot id: A0A8M1N4V2
uniprot id: A0A8M6Z8W0
names: Subcellular Location Annotation
messages: Nucleus

7955:LOC100536860
gene id: 7955:LOC100536860
uniprot id: A0A286Y9R5
uniprot id: A0A8M1RNX3
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPC subfamily.
messages: Cell membrane
messages: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
messages: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
messages: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
messages: Zona pellucida

7955:tax1bp3
gene id: 7955:tax1bp3
uniprot id: Q8AWD4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

7955:rorca
gene id: 7955:rorca
uniprot id: A3R3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

7955:si:ch1073-44g3.1
gene id: 7955:si:ch1073-44g3.1
uniprot id: A0A8M2BGY2
uniprot id: E7FH33
names: Similarity
messages: Belongs to the UPF0461 family.

7955:fam83hb
gene id: 7955:fam83hb
uniprot id: A0A8M2B6N0
uniprot id: G1K2R9
uniprot id: Q1LVV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM83 family.
messages: May play a role in keratin cytoskeleton disassembly.
messages: cytoskeleton

7955:ephb6
gene id: 7955:ephb6
uniprot id: A0A8M2BKS8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:LOC101885707
gene id: 7955:LOC101885707
uniprot id: A0A8M9Q334
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:ext1a
gene id: 7955:ext1a
uniprot id: A3KMS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

7955:adra1aa
gene id: 7955:adra1aa
uniprot id: A0A8M1P8T8
uniprot id: E7FG90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:spast
gene id: 7955:spast
uniprot id: A0A8M2B2A7
uniprot id: Q6NW58
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Branchiomotor neurons exhibit reduced axonal outgrowth and aberrant positioning of neuronal cell bodies. Outgrowth of motor axons from the spinal cord is impaired, the number and length of spinal motor neurons is reduced, and elevated levels of apoptosis are observed in the CNS. Thickened bundles of axonal microtubules are observed in the spinal cord. Longitudinal fascicles in the hindbrain are disordered. Most embryos are immotile and fail to hatch, while those that do exhibit reduced motility and swimming defects. Morpholino knockdown results in abnormal morphological features, including hydrocephalia, perturbed yolk sac extension and an arched-back phenotype, disorganized microtubule networks in the spinal cord and thinner microtubules in the spinal motor neuron axons, and in increased oxidative stress (PubMed:26744324). These phenotypes are rescued following exposure to the drugs methylene blue, guanabenz, salubrinal or phenazine (PubMed:26744324).
messages: Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Maternally expressed. Expressed at low levels throughout the embryo up to 24 hours post-fertilization (hpf).
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cytoskeleton
messages: perinuclear region

7955:gsg1l
gene id: 7955:gsg1l
uniprot id: Q4V922
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the AMPAR complex, modifies AMPA receptor (AMPAR) gating.
messages: Belongs to the GSG1 family.
messages: Cell membrane
messages: Component of the AMPAR complex.
messages: Synapse

7955:rfng
gene id: 7955:rfng
uniprot id: F1QXC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:taar20b
gene id: 7955:taar20b
uniprot id: A0A8M6Z0U9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:tgfbrap1
gene id: 7955:tgfbrap1
uniprot id: A4IG72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP1 family.
messages: Component of the putative class C core vacuole/endosome tethering (CORVET) complex (By similarity).
messages: Cytoplasm
messages: Early endosome
messages: Plays a role in the TGF-beta signaling pathway.
messages: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity).

7955:baiap2a
gene id: 7955:baiap2a
uniprot id: A0A8M2BAV5
uniprot id: A0A8M3AQY0
uniprot id: A0A8M3B8K0
uniprot id: A0A8M9PQ60
uniprot id: Q1RLU7
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

7955:ndufb10
gene id: 7955:ndufb10
uniprot id: Q6PC16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

7955:si:rp71-77l1.2
gene id: 7955:si:rp71-77l1.2
uniprot id: A0A8M1QKR2
uniprot id: X1WCU7
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:LOC563479
gene id: 7955:LOC563479
uniprot id: A0A8M6YZG0
names: Subcellular Location Annotation
messages: Membrane

7955:elavl4
gene id: 7955:elavl4
uniprot id: A0A0R4IEW8
uniprot id: A0A8M2BEA7
uniprot id: A0A8M6Z808
uniprot id: A0A8M9Q398
uniprot id: A0A8M9Q9I0
uniprot id: A0A8M9QIF9
uniprot id: F1QGR7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Expressed in motor neurons.
messages: Interacts with smn1.
messages: Perikaryon
messages: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (By similarity). Plays a role in the regulation of mRNA stability, alternative splicing and translation (By similarity). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Mainly plays a role in neuron-specific RNA processing (By similarity). Required for the maturation of motor neuron axonal branches and dendrites (PubMed:29061699).
messages: Reduced overall movement, decreased initiation of swim and turn movements and decreased mean body curvature change per swim half-cycle and mean number of swim half-cycles per swim (PubMed:29061699). At 2 and 4 dpf, decreased axonal branches and at 4 dpf, decreased dendrites in motor neurons (PubMed:29061699). Defects on motor neuron extensions persist at 26 dph (PubMed:29061699). Decreased GAP43 mRNA levels (PubMed:29061699).
messages: axon
messages: dendrite
messages: growth cone

7955:msi2b
gene id: 7955:msi2b
uniprot id: A0A8M2B3X1
uniprot id: A0A8M2B3X4
uniprot id: A0A8M2B414
uniprot id: A0A8M2B4J9
uniprot id: A0A8M3AIG3
uniprot id: A0A8M3ASN7
uniprot id: A0A8M9QBW9
uniprot id: A0A8M9QH54
uniprot id: Q7SXT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Musashi family.
messages: Cytoplasm

7955:si:dkey-188i13.6
gene id: 7955:si:dkey-188i13.6
uniprot id: A0A8M1P3U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

7955:ypel2b
gene id: 7955:ypel2b
uniprot id: E7F3A4
names: Similarity
messages: Belongs to the yippee family.

7955:LOC797181
gene id: 7955:LOC797181
uniprot id: A0A8M9QKF8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:zgc:63733
gene id: 7955:zgc:63733
uniprot id: Q6PGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMH3 family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: May be involved in Golgi maintenance and protein secretion.

7955:naa30
gene id: 7955:naa30
uniprot id: A0A8M1NLV5
uniprot id: B3DIS0
uniprot id: F1RAT9
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

7955:cul3b
gene id: 7955:cul3b
uniprot id: B3DIU1
names: Similarity
messages: Belongs to the cullin family.

7955:rln3b
gene id: 7955:rln3b
uniprot id: A0A8M9Q7S0
uniprot id: B1AAQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

7955:coro2ba
gene id: 7955:coro2ba
uniprot id: A0A8M9PPU8
uniprot id: A0A8M9Q2I6
names: Similarity
messages: Belongs to the WD repeat coronin family.

7955:si:ch211-207g17.3
gene id: 7955:si:ch211-207g17.3
uniprot id: A0A8M1Q278
uniprot id: F1QYD4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:tmc8
gene id: 7955:tmc8
uniprot id: A0A0G2LAK5
uniprot id: A0A8M3BDX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

7955:naa20
gene id: 7955:naa20
uniprot id: Q58ED9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. ARD1 subfamily.
messages: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
messages: Component of the N-terminal acetyltransferase B (NatB) complex which is composed of naa20 and naa25.
messages: Cytoplasm
messages: Nucleus

7955:rnf152
gene id: 7955:rnf152
uniprot id: A0A8M2BB62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

7955:zmp:0000000932
gene id: 7955:zmp:0000000932
uniprot id: A0A8M6Z510
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:si:dkey-58i8.5
gene id: 7955:si:dkey-58i8.5
uniprot id: A0A0G2KEU5
uniprot id: A0A8M1RHC6
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:actr6
gene id: 7955:actr6
uniprot id: Q7ZV86
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

7955:kdm5ba
gene id: 7955:kdm5ba
uniprot id: A0A2R8QQ41
uniprot id: A0A8M2BGK4
uniprot id: A0A8M9Q713
uniprot id: A5WUR6
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

7955:nsfl1c
gene id: 7955:nsfl1c
uniprot id: A0A8M3AV68
uniprot id: A0A8M9PF11
uniprot id: Q5U3U1
names: Subcellular Location Annotation
messages: Golgi stack

7955:tbcd
gene id: 7955:tbcd
uniprot id: A0A0R4IXD9
uniprot id: A0A8M1QKS2
names: Similarity
messages: Belongs to the TBCD family.

7955:cyp2y3
gene id: 7955:cyp2y3
uniprot id: Q4VBR9
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:arhgef28
gene id: 7955:arhgef28
uniprot id: A0A8M9PL62
uniprot id: A0A8M9PYS9
uniprot id: A0A8M9Q483
uniprot id: A0A8M9Q486
uniprot id: A0A8M9QEQ0
uniprot id: A0A8M9QEQ4
names: Subcellular Location Annotation
messages: Cytoplasm

7955:p2rx4a
gene id: 7955:p2rx4a
uniprot id: A0A8M3AWS5
uniprot id: A0A8M9PI33
uniprot id: Q98TZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

7955:pgfa
gene id: 7955:pgfa
uniprot id: A0A8M9PTL4
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:isca2
gene id: 7955:isca2
uniprot id: A0A8M1P3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

7955:ackr4a
gene id: 7955:ackr4a
uniprot id: A0A8M2BAW7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:rps6kal
gene id: 7955:rps6kal
uniprot id: A0A8M3B8E3
uniprot id: A0A8M9QGB2
uniprot id: Q6PFQ0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by multiple phosphorylations on threonine and serine residues.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
messages: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

7955:prkab1b
gene id: 7955:prkab1b
uniprot id: Q6NY31
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

7955:LOC798483
gene id: 7955:LOC798483
uniprot id: A0A8M1Q7E1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

7955:acsl5
gene id: 7955:acsl5
uniprot id: F1RAK0
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

7955:ccnc
gene id: 7955:ccnc
uniprot id: Q6STL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
messages: Nucleus

7955:tnfrsf1b
gene id: 7955:tnfrsf1b
uniprot id: A0A8M2B220
uniprot id: A0A8M2B2L3
uniprot id: F1RAS9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rsad1
gene id: 7955:rsad1
uniprot id: A4IGH2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity).
messages: Might carry two S-adenosyl-L-methionine binding sites with only one binding to the iron-sulfur cluster.
messages: Mitochondrion

7955:trak1
gene id: 7955:trak1
uniprot id: A0A8M3AIV7
uniprot id: A0A8M3AQA5
uniprot id: A0A8M3AT45
uniprot id: A0A8M3B1F5
uniprot id: A0A8M3B1F9
uniprot id: A0A8M9PMV3
uniprot id: E9QJ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

7955:dkk3b
gene id: 7955:dkk3b
uniprot id: A2CEU2
uniprot id: A3KNQ0
names: Similarity
messages: Belongs to the dickkopf family.

7955:pds5a
gene id: 7955:pds5a
uniprot id: A1L1F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDS5 family.
messages: Interacts with the cohesin complex. Binds chromatin in a cohesin-dependent manner (By similarity).
messages: May regulate sister chromatid cohesion during mitosis and couple it to DNA replication.
messages: Nucleus

7955:nxn
gene id: 7955:nxn
uniprot id: Q503L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoredoxin family.
messages: Functions as a redox-dependent negative regulator of the Wnt signaling pathway.
messages: Nucleus
messages: cytosol

7955:slc35b4
gene id: 7955:slc35b4
uniprot id: A0A8M1PFD3
uniprot id: F1Q9W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

7955:si:ch211-150i13.1
gene id: 7955:si:ch211-150i13.1
uniprot id: A0A2R8RNF7
uniprot id: A0A8M2B3Q5
uniprot id: A0A8M9PN09
uniprot id: A0A8M9PU72
uniprot id: A0A8M9Q1B0
uniprot id: F1QCL5
names: Subcellular Location Annotation
messages: ruffle membrane

7955:brinp3a.1
gene id: 7955:brinp3a.1
uniprot id: A9JTF7
names: Similarity
messages: Belongs to the BRINP family.

7955:eif4g3b
gene id: 7955:eif4g3b
uniprot id: A0A8M3AMY9
uniprot id: A0A8M3B668
uniprot id: A0A8M9P5G6
uniprot id: A0A8M9PFF4
uniprot id: A0A8M9PL50
uniprot id: A0A8M9PTH7
uniprot id: A0A8M9PWU5
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

7955:acvr1l
gene id: 7955:acvr1l
uniprot id: O73736
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:spen
gene id: 7955:spen
uniprot id: A0A8M1RN36
uniprot id: A0A8M3AMZ8
uniprot id: F1QMN6
names: Similarity
messages: Belongs to the RRM Spen family.

7955:pde8b
gene id: 7955:pde8b
uniprot id: A0A8M3ATN7
uniprot id: A0A8M3AWN1
uniprot id: A0A8M9P3K9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

7955:hspb11
gene id: 7955:hspb11
uniprot id: A0A0R4I9A8
uniprot id: A5JV83
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: By heat shock in the somites.
messages: Expressed specifically in the rostral-most somites at 24 hpf. At 48 hpf, expression continues in the rostral-most somites and also in the notochord. Somite expression was restricted to the vicinity of the horizontal myoseptum. In adults, expressed in the heart.

7955:si:ch211-199m3.4
gene id: 7955:si:ch211-199m3.4
uniprot id: A0A2R9YJL3
uniprot id: A0A8M3ALP1
uniprot id: A0A8N7T768
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme
messages: cilium basal body

7955:bmp5
gene id: 7955:bmp5
uniprot id: Q7T288
names: Similarity
messages: Belongs to the TGF-beta family.

7955:acana
gene id: 7955:acana
uniprot id: A0A8M2BDZ8
uniprot id: A0A8M9QD02
uniprot id: A0A8N7TAM5
uniprot id: E7F537
uniprot id: F1QDA1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:psma6b
gene id: 7955:psma6b
uniprot id: Q6DGY8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

7955:npepl1
gene id: 7955:npepl1
uniprot id: Q561T4
names: Similarity
messages: Belongs to the peptidase M17 family.

7955:clta
gene id: 7955:clta
uniprot id: E7F1Q8
uniprot id: E9QDE6
uniprot id: Q6P937
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

7955:slc25a26
gene id: 7955:slc25a26
uniprot id: B2GQ56
uniprot id: Q4V9P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity).
messages: Mitochondrion inner membrane

7955:mrpl42
gene id: 7955:mrpl42
uniprot id: A0A8M1P3T1
uniprot id: F1Q839
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

7955:LOC101884769
gene id: 7955:LOC101884769
uniprot id: A0A8M9PTX9
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:LOC562898
gene id: 7955:LOC562898
uniprot id: A0A8M6Z6T6
uniprot id: A0A8M9PMG5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:lamc3
gene id: 7955:lamc3
uniprot id: A0A8N7TEI9
uniprot id: F1QPJ1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

7955:sbds
gene id: 7955:sbds
uniprot id: Q7ZW65
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

7955:snx33
gene id: 7955:snx33
uniprot id: B5RHZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

7955:ppp3cca
gene id: 7955:ppp3cca
uniprot id: A0A286YA34
uniprot id: A0A8M1NSY8
uniprot id: A0A8M2BJ63
uniprot id: A3KGZ6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

7955:celf3a
gene id: 7955:celf3a
uniprot id: A0A8M9PGK3
uniprot id: Q9IBD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein that may be involved in the regulation of pre-mRNA alternative splicing.

7955:slc16a5b
gene id: 7955:slc16a5b
uniprot id: A0A8M1QL30
names: Subcellular Location Annotation
messages: Membrane

7955:b9d2
gene id: 7955:b9d2
uniprot id: Q6DGZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the B9D family.
messages: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
messages: Part of the tectonic-like complex (also named B9 complex).
messages: cilium axoneme
messages: cilium basal body

7955:ret
gene id: 7955:ret
uniprot id: A0A8N1Z2F3
uniprot id: A8E7C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

7955:pah
gene id: 7955:pah
uniprot id: Q6PHI7
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

7955:kif20ba
gene id: 7955:kif20ba
uniprot id: A0A8M1RFH9
uniprot id: E7FAN6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:LOC110440076
gene id: 7955:LOC110440076
uniprot id: A0A8M9Q6R2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:fap
gene id: 7955:fap
uniprot id: A0A8M1QUX2
uniprot id: B0R1C4
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

7955:itpk1a
gene id: 7955:itpk1a
uniprot id: B2GQN1
uniprot id: Q7ZU91
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ITPK1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis.
messages: Monomer.

7955:csf1ra
gene id: 7955:csf1ra
uniprot id: A0A8M9QKN6
uniprot id: B3DHL0
uniprot id: Q9I8N6
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated in response to CSF1 binding. autophosphorylation, leading to its degradation.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Monomer. Homodimer. Interacts with CSF1 (By similarity).
messages: Present in an inactive conformation in the absence of bound ligand. CSF1 binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).
messages: The activation loop plays an important role in the regulation of kinase activity. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase (By similarity).
messages: The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase (By similarity).
messages: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Activates several signaling pathways in response to ligand binding (By similarity).
messages: Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation (By similarity).

7955:taar10d
gene id: 7955:taar10d
uniprot id: A0A8M1NDG6
uniprot id: Q5QNN4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:cpeb3
gene id: 7955:cpeb3
uniprot id: A0A8M2BGS8
uniprot id: A0A8M3AZE0
uniprot id: A0A8M3AZG1
uniprot id: A0A8M3B5H6
uniprot id: A0A8M3B893
uniprot id: D0PNH8
names: Similarity
messages: Belongs to the RRM CPEB family.

7955:LOC108182773
gene id: 7955:LOC108182773
uniprot id: A0A8M9Q2Y2
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

7955:pomgnt1
gene id: 7955:pomgnt1
uniprot id: F1QNB2
uniprot id: Q0PIP4
uniprot id: Q4V907
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

7955:zdhhc5b
gene id: 7955:zdhhc5b
uniprot id: A0A8M2BH23
uniprot id: A0A8M3AI50
uniprot id: A0A8M3ASA6
uniprot id: E7FBS9
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Cell membrane
messages: Membrane
messages: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes.
messages: Probably maternally supplied, the zygotic expression is detected early during development at the 512-cell stage.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:LOC100536910
gene id: 7955:LOC100536910
uniprot id: A0A8M9QD94
names: Subcellular Location Annotation
messages: Membrane

7955:gpc1a
gene id: 7955:gpc1a
uniprot id: F1QCC6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.
messages: O-glycosylated with heparan sulfate side chains.
messages: extracellular space

7955:tek
gene id: 7955:tek
uniprot id: A0A8M3ARU2
uniprot id: A0A8M9PX37
uniprot id: O73791
names: Activity Regulation
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Angiopoietin binding leads to receptor dimerization and activation by autophosphorylation at Tyr-984 on the kinase activation loop.
messages: Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner, where Tyr-984 in the kinase activation loop is phosphorylated first, followed by autophosphorylation at additional tyrosine residues. Phosphorylation is important for interaction with scaffold proteins and effectors.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
messages: Cell junction
messages: Cell membrane
messages: Expressed in most populations of endothelial cells in 24 hours embryos. Not present in intersegmental vessels.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity).
messages: cytoskeleton
messages: focal adhesion

7955:map6b
gene id: 7955:map6b
uniprot id: A0A8M1RRG0
uniprot id: E7FFM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

7955:zgc:77880
gene id: 7955:zgc:77880
uniprot id: Q6P3H1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:usp12b
gene id: 7955:usp12b
uniprot id: A0A8N7TEM7
uniprot id: E7F4N9
names: Similarity
messages: Belongs to the peptidase C19 family.

7955:glra2
gene id: 7955:glra2
uniprot id: A0A8M9PSE3
uniprot id: D1KZ66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

7955:smpdl3b
gene id: 7955:smpdl3b
uniprot id: A0A8M1P530
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

7955:fam45a
gene id: 7955:fam45a
uniprot id: A8E7G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Guanine nucleotide exchange factor (GEF) which may be involved in the regulation of late endocytic pathway homeostasis, including endosomal positioning, maturation and secretion.
messages: Late endosome

7955:jpt1b
gene id: 7955:jpt1b
uniprot id: A0A8M2BAY7
uniprot id: Q6TGZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

7955:ypel3
gene id: 7955:ypel3
uniprot id: Q6NWI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the yippee family.
messages: May be involved in proliferation and apoptosis in myeloid precursor cells.
messages: nucleolus

7955:aamdc
gene id: 7955:aamdc
uniprot id: Q502H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAMDC family.
messages: Cytoplasm

7955:apopt1
gene id: 7955:apopt1
uniprot id: A0A8M1NTA1
uniprot id: B8A5M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

7955:keap1b
gene id: 7955:keap1b
uniprot id: A0A2R8Q1W5
uniprot id: A0A8M9Q5W8
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Homodimer and heterodimer; heterodimerizes with keap1a (PubMed:18057000). Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at least composed of 2 molecules of cul3, 2 molecules of keap1 (keap1a and/or keap1b), and rbx1 (By similarity). Interacts with nfe2l2/nrf2; the interaction is direct (By similarity).
messages: Keap1 contains reactive cysteine residues that act as sensors for endogenously produced and exogenously encountered small molecules, which react with sulfhydryl groups and modify the cysteine sensors, leading to impair ability of the BCR(KEAP1) complex to ubiquitinate target proteins.
messages: Non-enzymatic covalent modifications of reactive cysteines by electrophile metabolites inactivate the BCR(KEAP1) complex.
messages: Nucleus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination (PubMed:18057000). Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes (PubMed:18057000). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting nfe2l2/nrf2 nuclear accumulation and expression of phase II detoxifying enzymes (By similarity).
messages: Ubiquitin ligase activity of the BCR(KEAP1) complex is inhibited by oxidative stress and electrophile metabolites such as sulforaphane. Electrophile metabolites react with reactive cysteine residues in keap1 and trigger non-enzymatic covalent modifications of these cysteine residues, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex.
messages: Widely expressed.

7955:traf1
gene id: 7955:traf1
uniprot id: A0A8N7UZ20
uniprot id: B0UXK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

7955:uimc1
gene id: 7955:uimc1
uniprot id: A0A8M1RMY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

7955:tmem17
gene id: 7955:tmem17
uniprot id: A5D6V4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM17 family.
messages: Part of the tectonic-like complex (also named B9 complex).
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
messages: cilium membrane

7955:si:dkey-121j17.5
gene id: 7955:si:dkey-121j17.5
uniprot id: A0A8M6Z2R2
uniprot id: A0A8M9PT30
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

7955:plxnb1b
gene id: 7955:plxnb1b
uniprot id: F1Q7U0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:pcdh2ab12
gene id: 7955:pcdh2ab12
uniprot id: Q60I65
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:ncapd3
gene id: 7955:ncapd3
uniprot id: Q7SZF2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.

7955:kcnj14
gene id: 7955:kcnj14
uniprot id: F1R7M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:zp2.3
gene id: 7955:zp2.3
uniprot id: A0A8M1P714
uniprot id: F1QMZ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:wnt11
gene id: 7955:wnt11
uniprot id: A0A8M3B2Q8
uniprot id: B8JM95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:acsm3
gene id: 7955:acsm3
uniprot id: A0A8M9QIK8
uniprot id: A9JRA7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:s100b
gene id: 7955:s100b
uniprot id: Q6DGT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

7955:aldh9a1b
gene id: 7955:aldh9a1b
uniprot id: A0A8M3AVP0
uniprot id: B2GT49
uniprot id: Q802W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.
messages: Homotetramer.
messages: cytosol

7955:cyp27a1.2
gene id: 7955:cyp27a1.2
uniprot id: A0A8M1PYU3
uniprot id: E9QJ06
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:pigw
gene id: 7955:pigw
uniprot id: A0A8M1NHN2
uniprot id: F1QAR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

7955:cpdb
gene id: 7955:cpdb
uniprot id: A0A8M1PA92
uniprot id: E7FFQ7
names: Similarity
messages: Belongs to the peptidase M14 family.

7955:gosr1
gene id: 7955:gosr1
uniprot id: A0A8M2B4E0
uniprot id: E9QFW9
uniprot id: E9QH18
uniprot id: Q567G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

7955:si:ch1073-174d20.2
gene id: 7955:si:ch1073-174d20.2
uniprot id: A0A8M2BAK7
uniprot id: E7F6D6
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

7955:opn7b
gene id: 7955:opn7b
uniprot id: E7FEE5
names: Subcellular Location Annotation
messages: Membrane

7955:kdelc1
gene id: 7955:kdelc1
uniprot id: Q7ZVE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KDELC family.
messages: Endoplasmic reticulum lumen
messages: Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently.

7955:atg5
gene id: 7955:atg5
uniprot id: F1RDC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

7955:bet1
gene id: 7955:bet1
uniprot id: Q6IQT6
names: Subcellular Location Annotation
messages: Membrane

7955:kcnmb2
gene id: 7955:kcnmb2
uniprot id: Q5BL22
names: Subcellular Location Annotation
messages: Membrane

7955:pim1
gene id: 7955:pim1
uniprot id: B2GPH4
uniprot id: Q08BC0
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

7955:taar14a
gene id: 7955:taar14a
uniprot id: A0A8M1NCF1
uniprot id: Q5RFY4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:dctn1a
gene id: 7955:dctn1a
uniprot id: A0A8M9Q1C7
uniprot id: Q07DR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

7955:pcdh1g29
gene id: 7955:pcdh1g29
uniprot id: I6LC18
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:nxph2a
gene id: 7955:nxph2a
uniprot id: E7FBT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

7955:myo3b
gene id: 7955:myo3b
uniprot id: A0A8M1QKE9
uniprot id: A0A8M9PSI3
uniprot id: A0A8M9QFR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

7955:bbs5
gene id: 7955:bbs5
uniprot id: Q7ZWB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS5 family.
messages: Required for ciliogenesis.
messages: centriolar satellite
messages: cilium membrane

7955:casp8
gene id: 7955:casp8
uniprot id: A0A8M2BD46
uniprot id: Q66I19
names: Similarity
messages: Belongs to the peptidase C14A family.

7955:adssl
gene id: 7955:adssl
uniprot id: Q8JGR3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

7955:psmg2
gene id: 7955:psmg2
uniprot id: Q1LXS2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg1.
messages: Degraded by the proteasome upon completion of 20S proteasome maturation.
messages: Forms a heterodimer with psmg1.
messages: Nucleus

7955:ubxn10
gene id: 7955:ubxn10
uniprot id: Q0P3Z8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UBXN10 family.
messages: Defects in left-right asymmetry during embryogenesis, due to defects in ciliogenesis.
messages: Required for ciliogenesis (PubMed:26389662). Acts as a tethering factor that facilitates recruitment of vcp/p97 to the intraflagellar transport complex B (IFT-B) in cilia (By similarity).
messages: cilium

7955:aste1b
gene id: 7955:aste1b
uniprot id: A0A8M1PSR0
uniprot id: E7F2I2
names: Similarity
messages: Belongs to the asteroid family.

7955:ltv1
gene id: 7955:ltv1
uniprot id: A0A8M1N0C3
uniprot id: A0A8M9PP26
uniprot id: F1R9T9
names: Similarity
messages: Belongs to the LTV1 family.

7955:sec63
gene id: 7955:sec63
uniprot id: Q6DGY6
names: Subcellular Location Annotation
messages: Membrane

7955:pkp3a
gene id: 7955:pkp3a
uniprot id: A0A8M2BHY3
uniprot id: F1Q8J9
uniprot id: Q1JPT2
names: Similarity
messages: Belongs to the beta-catenin family.

7955:zdhhc7
gene id: 7955:zdhhc7
uniprot id: Q6DHI1
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Golgi apparatus membrane
messages: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable).
messages: Homooligomers.
messages: Probably maternally supplied. No zygotic expression is detected before 7.5 hpf.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:ubac2
gene id: 7955:ubac2
uniprot id: A1L247
names: Subcellular Location Annotation
messages: Membrane

7955:si:dkey-112e17.1
gene id: 7955:si:dkey-112e17.1
uniprot id: A0A8M6YZ85
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tubb1
gene id: 7955:tubb1
uniprot id: A0A8M1P7X5
uniprot id: E7FC32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:cryba2b
gene id: 7955:cryba2b
uniprot id: Q45FX9
uniprot id: Q6DGY2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

7955:mknk2b
gene id: 7955:mknk2b
uniprot id: Q803R1
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:seh1l
gene id: 7955:seh1l
uniprot id: A0A8M9PRC2
uniprot id: Q6TGU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). Probably part of the GATOR complex.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore
messages: nuclear pore complex

7955:stat1a
gene id: 7955:stat1a
uniprot id: O93598
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

7955:wnt6b
gene id: 7955:wnt6b
uniprot id: A0A8M1RNK5
uniprot id: F1R205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:rpl5b
gene id: 7955:rpl5b
uniprot id: Q6IQB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

7955:kcnk10a
gene id: 7955:kcnk10a
uniprot id: A0A0U1XE45
uniprot id: A3QJX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:ftr06
gene id: 7955:ftr06
uniprot id: A0A8M9PC86
names: Similarity
messages: Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.

7955:eif4h
gene id: 7955:eif4h
uniprot id: A0A0R4ICV9
uniprot id: A0A0R4IG09
uniprot id: A0A8M1NUW6
uniprot id: A0A8M1NXE7
uniprot id: A0A8M1PK31
uniprot id: A0A8M3AI90
uniprot id: F1QYM4
names: Function
names: Subcellular Location Annotation
messages: Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
messages: perinuclear region

7955:aldh1l1
gene id: 7955:aldh1l1
uniprot id: E3NZ06
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

7955:ptk2ab
gene id: 7955:ptk2ab
uniprot id: A0A2R8RR02
uniprot id: A0A8M2B4H7
uniprot id: A0A8M2B4I9
uniprot id: A0A8M2B500
uniprot id: A0A8M2B527
uniprot id: A0A8M3B1R9
uniprot id: A0A8M9NZ18
uniprot id: A0A8M9NZ24
uniprot id: A0A8M9P7Q1
uniprot id: A0A8M9P7Q4
uniprot id: A0A8M9P7Q9
uniprot id: A0A8M9PCW2
uniprot id: A0A8M9PCW5
uniprot id: A0A8M9PCX0
uniprot id: A0A8M9PJ68
uniprot id: A0A8M9PJ73
uniprot id: A0A8M9PM54
uniprot id: A0A8M9PM62
uniprot id: Q98SN4
names: Subcellular Location Annotation
messages: Cell membrane
messages: focal adhesion

7955:dlgap4a
gene id: 7955:dlgap4a
uniprot id: A0A8M9PLE1
names: Similarity
messages: Belongs to the SAPAP family.

7955:acvr2ab
gene id: 7955:acvr2ab
uniprot id: A0A0R4ISZ9
uniprot id: A0A8M2BGK0
uniprot id: A0A8M3B327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

7955:fgf11a
gene id: 7955:fgf11a
uniprot id: A0A8M9QGZ2
uniprot id: Q5TKR4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7955:ostf1
gene id: 7955:ostf1
uniprot id: Q6TGW5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

7955:or115-15
gene id: 7955:or115-15
uniprot id: Q90428
names: Subcellular Location Annotation
messages: Membrane

7955:tmbim1a
gene id: 7955:tmbim1a
uniprot id: A0A8M1N2B3
uniprot id: X1WGS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7955:ca10a
gene id: 7955:ca10a
uniprot id: Q3B739
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

7955:si:dkey-30e9.7
gene id: 7955:si:dkey-30e9.7
uniprot id: A0A0R4IWA2
uniprot id: A0A8M1PVC7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:birc2
gene id: 7955:birc2
uniprot id: A0A2R8QDZ3
uniprot id: A0A8M6YUF8
uniprot id: Q7T0K2
uniprot id: Q8UWD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

7955:fabp1b.2
gene id: 7955:fabp1b.2
uniprot id: A0A0R4IRM6
uniprot id: A0A8M1RKB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

7955:ppa1b
gene id: 7955:ppa1b
uniprot id: Q568N9
names: Similarity
messages: Belongs to the PPase family.

7955:krt95
gene id: 7955:krt95
uniprot id: Q6DG66
names: Similarity
messages: Belongs to the intermediate filament family.

7955:atp5j
gene id: 7955:atp5j
uniprot id: B8JM34
uniprot id: Q6NYF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

7955:si:dkey-202l22.6
gene id: 7955:si:dkey-202l22.6
uniprot id: A0A0R4IA28
names: Subcellular Location Annotation
messages: Nucleus

7955:zgc:66455
gene id: 7955:zgc:66455
uniprot id: Q7SXC1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:nr4a3
gene id: 7955:nr4a3
uniprot id: A0A8M1NVW2
uniprot id: A0A8M3AQK6
uniprot id: F1R8N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Nucleus

7955:lyrm9
gene id: 7955:lyrm9
uniprot id: B3DFV0
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

7955:si:ch73-173p19.2
gene id: 7955:si:ch73-173p19.2
uniprot id: A0A8M9P680
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

7955:dlg2
gene id: 7955:dlg2
uniprot id: A0A8M3AWU6
uniprot id: A0A8M3AWV0
uniprot id: A0A8M3AWV4
uniprot id: A0A8M3AWW1
uniprot id: A0A8M3AWW5
uniprot id: A0A8M3AWW9
uniprot id: A0A8M3AWX1
uniprot id: A0A8M3AWX6
uniprot id: A0A8M3AWY0
uniprot id: A0A8M3AWY5
uniprot id: A0A8M3AWY7
uniprot id: A0A8M3B3C1
uniprot id: A0A8M3B3C4
uniprot id: A0A8M3B3C7
uniprot id: A0A8M3B3D0
uniprot id: A0A8M3B3D4
uniprot id: A0A8M3B3D7
uniprot id: A0A8M3B6A6
uniprot id: A0A8M3B6B1
uniprot id: A0A8M3B6B4
uniprot id: A0A8M3B6B8
uniprot id: A0A8M3B6C1
uniprot id: A0A8M3BD31
uniprot id: A0A8M3BD36
uniprot id: A0A8M3BD37
uniprot id: A0A8M3BD41
uniprot id: A0A8M3BD47
uniprot id: A0A8M3BD50
uniprot id: A0A8M9QC28
uniprot id: Q5PYH7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: At 4 days-post-fertilization (dpf), expressed strongly in the inner and outer plexiform layers and ganglion cell layer of the retina, in the tegmentum and in the hindbrain. Also expressed diffusely in the diencephalon.
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: May play a role in synapse assembly and function.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Synapse
messages: axon

7955:ugt1a4
gene id: 7955:ugt1a4
uniprot id: B5DDQ4
uniprot id: Q561S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:pld1b
gene id: 7955:pld1b
uniprot id: A0A8M9PGG2
names: Similarity
messages: Belongs to the phospholipase D family.

7955:pgk1
gene id: 7955:pgk1
uniprot id: Q7ZV29
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

7955:mgst2
gene id: 7955:mgst2
uniprot id: Q1ECY7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

7955:cxcl20
gene id: 7955:cxcl20
uniprot id: A0A8M3B9T3
uniprot id: A9ZPF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:svopa
gene id: 7955:svopa
uniprot id: A0A8M2BCL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

7955:mettl26
gene id: 7955:mettl26
uniprot id: Q7ZVJ8
names: Similarity
messages: Belongs to the UPF0585 family.

7955:ube2h
gene id: 7955:ube2h
uniprot id: Q7ZUF3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:rhbdd1
gene id: 7955:rhbdd1
uniprot id: A0A8M9QLE2
uniprot id: Q568J3
names: Subcellular Location Annotation
messages: Membrane

7955:plekhf2
gene id: 7955:plekhf2
uniprot id: Q7ZUV1
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endoplasmic reticulum
messages: May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
messages: The FYVE domain is important for binding to the endosomal membrane.

7955:map4k5
gene id: 7955:map4k5
uniprot id: A0A8M2B328
uniprot id: A0A8M2B3T3
uniprot id: A0A8M3AZ98
uniprot id: A0A8M9Q9K2
uniprot id: A0A8M9QF91
uniprot id: A0A8M9QJK1
uniprot id: A0A8M9QNA9
uniprot id: B8A6G9
uniprot id: Q7ZUA2
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

7955:arrdc1a
gene id: 7955:arrdc1a
uniprot id: A0A8M2BJ09
uniprot id: A7YYD6
uniprot id: Q6ZM71
names: Similarity
messages: Belongs to the arrestin family.

7955:tmem106ba
gene id: 7955:tmem106ba
uniprot id: A0A8M1PED6
uniprot id: F1QCQ2
names: Similarity
messages: Belongs to the TMEM106 family.

7955:pparaa
gene id: 7955:pparaa
uniprot id: A0A8M1NRP3
uniprot id: Q5RGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

7955:LOC100330151
gene id: 7955:LOC100330151
uniprot id: A0A8M3AP37
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:map3k12
gene id: 7955:map3k12
uniprot id: A0A8M2BER7
uniprot id: Q6NYW1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

7955:smg8
gene id: 7955:smg8
uniprot id: A0A8N7T6K6
uniprot id: E7FBA3
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

7955:psma6a
gene id: 7955:psma6a
uniprot id: A0A8M1P7V6
uniprot id: Q7SXN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

7955:cx28.6
gene id: 7955:cx28.6
uniprot id: A0A8M2BH46
uniprot id: F1QZN0
uniprot id: Q8AWR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:LOC562362
gene id: 7955:LOC562362
uniprot id: A0A8M9PLJ2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:sema6bb
gene id: 7955:sema6bb
uniprot id: A0A8M9PS42
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:trmt2b
gene id: 7955:trmt2b
uniprot id: A0A0R4I9B6
uniprot id: A4QP75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA. Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs. Specifically methylates the uridine in position 429 of 12S rRNA (m5U429). Does not affect RNA stability or mitochondrial translation.
messages: Mitochondrion

7955:LOC795802
gene id: 7955:LOC795802
uniprot id: A0A8M1PU97
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:eif3c
gene id: 7955:eif3c
uniprot id: A0A8M2B2W0
uniprot id: Q6PFQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

7955:tsr2
gene id: 7955:tsr2
uniprot id: A0A8M9PQP0
uniprot id: Q8JGT2
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

7955:eif5
gene id: 7955:eif5
uniprot id: Q7ZWA9
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

7955:kif1c
gene id: 7955:kif1c
uniprot id: A0A8M2BJB1
uniprot id: A0A8M3B025
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:cdk21
gene id: 7955:cdk21
uniprot id: A0A8M2BBE2
uniprot id: E7F5L4
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:dkey-172o19.2
gene id: 7955:si:dkey-172o19.2
uniprot id: A0A8M2BHV4
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

7955:eif4ebp3l
gene id: 7955:eif4ebp3l
uniprot id: Q98TT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF4E-binding protein family.
messages: Interacts with eif4e1a.
messages: Regulates eif4e1a activity by preventing its assembly into the eIF4F complex.

7955:corin
gene id: 7955:corin
uniprot id: A0A8M3AP01
uniprot id: A0A8M6YVI3
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:foxe1
gene id: 7955:foxe1
uniprot id: A0A8M2B6T0
names: Subcellular Location Annotation
messages: Nucleus

7955:slc7a14b
gene id: 7955:slc7a14b
uniprot id: A0A8N7UUN8
uniprot id: E7F8S7
names: Subcellular Location Annotation
messages: Membrane

7955:cpne2
gene id: 7955:cpne2
uniprot id: A0A2R8Q0R6
uniprot id: A0A8M2B629
uniprot id: A0A8N7UYA4
uniprot id: Q1LX40
names: Similarity
messages: Belongs to the copine family.

7955:smu1b
gene id: 7955:smu1b
uniprot id: A0A8M1RN57
uniprot id: A0A8M6YZI5
uniprot id: E7FFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

7955:gbe1b
gene id: 7955:gbe1b
uniprot id: A0A8M3AIA9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

7955:psap
gene id: 7955:psap
uniprot id: A0A8M1P746
uniprot id: A0A8M1P781
uniprot id: B8JI17
uniprot id: E7FCT1
names: Function
names: Subcellular Location Annotation
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

7955:vps35
gene id: 7955:vps35
uniprot id: A0A8M1N767
uniprot id: A4QP42
uniprot id: Q1ED30
uniprot id: Q6ZM34
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

7955:e2f8
gene id: 7955:e2f8
uniprot id: F1QZ88
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator and promoting expression of vegfa.
messages: Belongs to the E2F/DP family.
messages: Embryos lacking both e2f7 and e2f8 contain multiple intersegmental arteries that completely fail to migrate from the dorsal aorta. Gross morphology of these embryos and initial formation of main axial vessels are unaltered.
messages: Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with e2f7.
messages: In contrast to classical members of the E2F transcription factor, atypical members contain 2 DNA-binding domains and regulate transcription in a DP-independent manner. Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity).
messages: Nucleus

7955:ptp4a1
gene id: 7955:ptp4a1
uniprot id: A0A8M9QD25
uniprot id: F1QSC9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

7955:cyp2aa9
gene id: 7955:cyp2aa9
uniprot id: A0PGL8
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:upf1
gene id: 7955:upf1
uniprot id: A0A8M2BAV2
uniprot id: F1RCY6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm
messages: Expressed during early cleavage, gastrulation and at 1 day post-fertilization.
messages: Morpholino knockdown leads to both intermediate and severe phenotypes of abnormal embryonic development (PubMed:21227923, PubMed:19414594). Intermediate phenotypes show developmental delay, including aberrant formation of the head, tail, eye placodes and somites (PubMed:21227923, PubMed:19414594). Severe phenotypes show severe developmental arrest, including yolk extension defects, and lack of recognizable morphological development (PubMed:21227923, PubMed:19414594). High mortality rates of 80% to 85% at 5 days post-fertilization (PubMed:19414594). Increase in premature stop codon containing slc24a5 mRNA transcript levels in melanocytes (PubMed:21227923, PubMed:19414594).
messages: Nucleus
messages: P-body
messages: RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an upf1-upf2-upf3 surveillance complex is believed to activate NMD.
messages: perinuclear region

7955:ankrd46b
gene id: 7955:ankrd46b
uniprot id: Q6TNT2
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch73-368j24.8
gene id: 7955:si:ch73-368j24.8
uniprot id: Q05AK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:endouc
gene id: 7955:endouc
uniprot id: Q1LUM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENDOU family.
messages: Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites.
messages: Monomer.
messages: Secreted

7955:gls2a
gene id: 7955:gls2a
uniprot id: A0A8M1Q7Y1
uniprot id: A0A8M9PZE4
names: Similarity
messages: Belongs to the glutaminase family.

7955:fxyd6
gene id: 7955:fxyd6
uniprot id: Q7SZ52
names: Similarity
messages: Belongs to the FXYD family.

7955:kifc1
gene id: 7955:kifc1
uniprot id: A4QNZ0
uniprot id: Q1LUU7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:atg3
gene id: 7955:atg3
uniprot id: Q6PFS7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG3 family.
messages: Conjugated to atg12 at Lys-246. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy (By similarity).
messages: Cytoplasm
messages: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of atg12 to itself, atg12 conjugation to atg3 playing a role in mitochondrial homeostasis but not in autophagy. atg7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with atg3 (By similarity).
messages: Interacts with atg7 and atg12. The complex composed of atg3 and atg7 plays a role in the conjugation of atg12 to atg5.

7955:LOC100150038
gene id: 7955:LOC100150038
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:ier2a
gene id: 7955:ier2a
uniprot id: A0A0M3HEM8
uniprot id: A0A8M1NQN6
names: Similarity
messages: Belongs to the IER family.

7955:cdh13
gene id: 7955:cdh13
uniprot id: A0A8M6YUA6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

7955:ube2d1b
gene id: 7955:ube2d1b
uniprot id: Q6PC58
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:slc25a47a
gene id: 7955:slc25a47a
uniprot id: A0A8M6YU82
uniprot id: A0A8M9PBY2
uniprot id: A0A8M9PHJ4
uniprot id: Q1ECW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

7955:kcna2b
gene id: 7955:kcna2b
uniprot id: A9JTD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane

7955:susd5
gene id: 7955:susd5
uniprot id: A0A8M3ASV6
uniprot id: E7EYM4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100536673
gene id: 7955:LOC100536673
uniprot id: A0A8M1RFP8
uniprot id: E7FDN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

7955:ralbb
gene id: 7955:ralbb
uniprot id: Q6IQE6
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

7955:lsm14aa
gene id: 7955:lsm14aa
uniprot id: A0A8M2BAB1
uniprot id: A0A8M9P6D7
uniprot id: A0A8M9PUV2
uniprot id: Q6P111
names: Similarity
messages: Belongs to the LSM14 family.

7955:rxfp2a
gene id: 7955:rxfp2a
uniprot id: A0A0R3P9B9
uniprot id: A0A8M1PA79
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:nkx1.2la
gene id: 7955:nkx1.2la
uniprot id: A0A8N7V0C0
uniprot id: B8A4P8
names: Subcellular Location Annotation
messages: Nucleus

7955:cx34.5
gene id: 7955:cx34.5
uniprot id: Q5TYP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

7955:si:dkeyp-75h12.5
gene id: 7955:si:dkeyp-75h12.5
uniprot id: E7FEX9
names: Subcellular Location Annotation
messages: Secreted

7955:zmp:0000001082
gene id: 7955:zmp:0000001082
uniprot id: A0A8M2BI95
uniprot id: A0A8M2BIC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:gys2
gene id: 7955:gys2
uniprot id: Q502K7
uniprot id: Q5RGX8
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

7955:pick1
gene id: 7955:pick1
uniprot id: Q08BM4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

7955:arsk
gene id: 7955:arsk
uniprot id: A0A8M9Q3L2
uniprot id: Q08CJ7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity).
messages: Lysosome
messages: Secreted
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

7955:phf8
gene id: 7955:phf8
uniprot id: P0CH95
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: First detected at 14 hours post-fertilization (hpf) in the head and tail regions. Found mostly in the head region. Also detectable in the jaw of the embryo at 3 dpf.
messages: Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity). Required for brain development, probably by regulating expression of neuron-specific genes.
messages: Morpholino knockdown of the protein results in defects in brain and craniofacial development. Embryos show delays in brain development at 24 hpf and apoptosis in the developing brain and the neural tube at 30 hpf.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 promotes its access to H3K9me2 (By similarity).
messages: The linker region is a critical determinant of demethylase specificity. It enables the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3 (By similarity).
messages: nucleolus

7955:fam151a
gene id: 7955:fam151a
uniprot id: A5PN38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM151 family.
messages: Membrane

7955:rxraa
gene id: 7955:rxraa
uniprot id: A0A8M1NUK0
uniprot id: A0A8M2B855
uniprot id: A0A8M2B8E9
uniprot id: F1Q4V9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

7955:yipf2
gene id: 7955:yipf2
uniprot id: Q6DBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

7955:pcdh1g26
gene id: 7955:pcdh1g26
uniprot id: I6LC14
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:emc10
gene id: 7955:emc10
uniprot id: A0A8M1NV41
uniprot id: A7E2M3
uniprot id: E9QGR8
uniprot id: F1QB44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC10 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.

7955:slc24a4a
gene id: 7955:slc24a4a
uniprot id: A0A8M2B5T1
uniprot id: A0A8M3AJ61
uniprot id: Q567G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

7955:taar10a
gene id: 7955:taar10a
uniprot id: Q5QNP6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:adam12
gene id: 7955:adam12
uniprot id: A0A8M6YVV0
uniprot id: A0A8M9PPK4
uniprot id: A0A8M9QJC4
uniprot id: A0A8M9QN43
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:ch1073-278o19.1
gene id: 7955:si:ch1073-278o19.1
uniprot id: A0A0R4IDX9
uniprot id: A0A8M9Q7T5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ninjurin family.
messages: Cell membrane
messages: Homooligomer.
messages: Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal region (By similarity). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (By similarity). Acts as a mediator of both programmed and necrotic cell death (By similarity). Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Acts as a regulator of angiogenesis (By similarity). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Also involved in striated muscle growth and differentiation (PubMed:31091274).
messages: Membrane
messages: Morpholino knockdown of the protein results in impaired heart and skeletal muscle development.

7955:zgc:153426
gene id: 7955:zgc:153426
uniprot id: Q08C80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:eif4g1a
gene id: 7955:eif4g1a
uniprot id: A0A8M3B020
uniprot id: A1L1W1
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

7955:utrn
gene id: 7955:utrn
uniprot id: A0A8M9P595
names: Function
names: Subcellular Location Annotation
messages: May play a role in anchoring the cytoskeleton to the plasma membrane.
messages: cytoskeleton

7955:nr5a1a
gene id: 7955:nr5a1a
uniprot id: A0A8M9Q3M8
uniprot id: Q9IAI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

7955:pcnx
gene id: 7955:pcnx
uniprot id: A0A8M2B3D9
uniprot id: A0A8M3AZC3
uniprot id: A0A8M3B5G2
uniprot id: A0A8M3B880
uniprot id: A0A8M3BET8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:dnah2
gene id: 7955:dnah2
uniprot id: A0A1D5NT12
uniprot id: A0A8M3B142
names: Similarity
messages: Belongs to the dynein heavy chain family.

7955:rev1
gene id: 7955:rev1
uniprot id: A0A8M2BF27
uniprot id: A0A8M3AVZ1
uniprot id: A0A8M6Z8G9
uniprot id: B0UY97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

7955:katnal2
gene id: 7955:katnal2
uniprot id: Q32PM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

7955:camk2a
gene id: 7955:camk2a
uniprot id: Q32PV2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

7955:lyve1b
gene id: 7955:lyve1b
uniprot id: A0A2R8QLT6
uniprot id: A0A8M1P976
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pik3ca
gene id: 7955:pik3ca
uniprot id: F1QAD7
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

7955:naif1
gene id: 7955:naif1
uniprot id: A0A8M1NJ84
uniprot id: A0A8M3AUW5
uniprot id: A0A8M3B1Q7
uniprot id: B0S5D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

7955:rasgrf2b
gene id: 7955:rasgrf2b
uniprot id: A2CEA7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and rac1 through the exchange of bound GDP for GTP. May function in synaptic plasticity.
messages: The DH (DBL-homology) domain is required for rac1 activation.
messages: The IQ domain is dispensable for the Ras-GEF activity.
messages: The Ras-GEF domain and the N-terminal Ras-GEF domain mediate Ras activation.

7955:baxa
gene id: 7955:baxa
uniprot id: B2GR48
uniprot id: Q9I9N4
names: Similarity
messages: Belongs to the Bcl-2 family.

7955:bdkrb2
gene id: 7955:bdkrb2
uniprot id: A0A8M3AR39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

7955:blk
gene id: 7955:blk
uniprot id: A0A8M6YUU4
uniprot id: Q5TYU7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

7955:snx8a
gene id: 7955:snx8a
uniprot id: A0A8M1P923
uniprot id: F6NGW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

7955:zgc:101806
gene id: 7955:zgc:101806
uniprot id: A0A2R8RJF7
uniprot id: A0A8M1N2F6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:st8sia1
gene id: 7955:st8sia1
uniprot id: A1A5W4
uniprot id: Q6KC13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

7955:jag2a
gene id: 7955:jag2a
uniprot id: A0A8M2B354
uniprot id: A0A8N7TDN4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

7955:mmab
gene id: 7955:mmab
uniprot id: A0A8M1NBZ7
uniprot id: A2BGN0
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

7955:agxt2
gene id: 7955:agxt2
uniprot id: Q4V8R2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

7955:gar1
gene id: 7955:gar1
uniprot id: A0A8M1PDT4
uniprot id: F1RAE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

7955:tas2r3
gene id: 7955:tas2r3
uniprot id: A6P6V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

7955:b3gnt9
gene id: 7955:b3gnt9
uniprot id: A0A8M9PD09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:tlcd2
gene id: 7955:tlcd2
uniprot id: A8WGS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLCD family.
messages: Cell membrane
messages: Regulates the composition and fluidity of the plasma membrane (By similarity). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does not appear to have any effect on LCPUFA synthesis (By similarity).

7955:ubp1
gene id: 7955:ubp1
uniprot id: A0A8M2B6I9
uniprot id: A3KPT8
uniprot id: A8WFT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

7955:cacna1g
gene id: 7955:cacna1g
uniprot id: A0A8M6Z219
uniprot id: A0A8M6Z3L0
uniprot id: A0A8M6Z8Y9
uniprot id: A0A8M9PX46
uniprot id: A0A8M9Q929
uniprot id: A0A8M9QER1
uniprot id: A0A8M9QER5
uniprot id: A0A8M9QJ76
uniprot id: A0A8M9QMZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

7955:bsnb
gene id: 7955:bsnb
uniprot id: A0A8M2B2S6
names: Subcellular Location Annotation
messages: Presynaptic active zone

7955:gbp2
gene id: 7955:gbp2
uniprot id: A0A8N7TFH1
uniprot id: E9QF26
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:snrnp27
gene id: 7955:snrnp27
uniprot id: Q6DH74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

7955:rad9b
gene id: 7955:rad9b
uniprot id: A0A8M1P8A7
uniprot id: B0S509
names: Similarity
messages: Belongs to the rad9 family.

7955:stk10
gene id: 7955:stk10
uniprot id: Q7SY52
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylates.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane
messages: Homodimer.
messages: May act as a polo kinase kinase by mediating phosphorylation of plk1.

7955:cops5
gene id: 7955:cops5
uniprot id: Q6PC30
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9.
messages: Nucleus
messages: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex.
messages: The CSN complex is associated with some 'Lys-63'-specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the brcc3/brcc36 component of the BRISC complex (By similarity).
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).
messages: cytosol
messages: perinuclear region
messages: synaptic vesicle

7955:rnf40
gene id: 7955:rnf40
uniprot id: Q08CR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

7955:LOC110439968
gene id: 7955:LOC110439968
uniprot id: A0A8M9PQH4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:im:7156467
gene id: 7955:im:7156467
uniprot id: A0A8M9PKU1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:chpfb
gene id: 7955:chpfb
uniprot id: A0A8M1QHW1
uniprot id: E7F9K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7955:slc19a2
gene id: 7955:slc19a2
uniprot id: A0A8M2BG00
uniprot id: E7F340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

7955:chpf2
gene id: 7955:chpf2
uniprot id: A0A8M1PUJ0
uniprot id: F1Q679
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

7955:notch2
gene id: 7955:notch2
uniprot id: A0A8M1NI29
uniprot id: F1RCH4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

7955:arl3l2
gene id: 7955:arl3l2
uniprot id: A0A140LG87
uniprot id: A0A8M2BGU1
uniprot id: Q6PC43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

7955:slc6a14
gene id: 7955:slc6a14
uniprot id: A0A8M1P905
uniprot id: F6NN04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:tmem57b
gene id: 7955:tmem57b
uniprot id: A0A8M2B3V6
uniprot id: A0A8M9Q9L5
uniprot id: Q2TLY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Endoplasmic reticulum membrane
messages: May play a role in the regulation of neuronal activity.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane
messages: axon

7955:gria1a
gene id: 7955:gria1a
uniprot id: A0A8M2BKK3
uniprot id: Q71E65
names: Subcellular Location Annotation
messages: Membrane

7955:hoxd12a
gene id: 7955:hoxd12a
uniprot id: A0A8M1NJM5
uniprot id: B0S5Y9
uniprot id: Q90471
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: First expressed at 14 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 17. Also expressed in the developing hindgut, except in the most distal portion. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

7955:pcyox1l
gene id: 7955:pcyox1l
uniprot id: A0A8M3AX62
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

7955:serpinc1
gene id: 7955:serpinc1
uniprot id: Q8AYE3
names: Similarity
messages: Belongs to the serpin family.

7955:crybb3
gene id: 7955:crybb3
uniprot id: Q52JI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

7955:ubap1
gene id: 7955:ubap1
uniprot id: F6P6X0
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of an ESCRT-I complex (endosomal sorting complex required for transport I).
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs).
messages: Endosome
messages: Impaired motor neuron outgrowth, leading to decreased mobility and shorter lifespan (PubMed:31203368). Axon lengths is significantly shorter in motor neurons (PubMed:30929741, PubMed:31203368).
messages: The UMA domain mediates association with the ESCRT-I complex.
messages: cytosol

7955:adprhl1
gene id: 7955:adprhl1
uniprot id: A0A8M2BFH0
uniprot id: A0A8M9Q1Y9
uniprot id: A0A8M9Q266
uniprot id: Q5XJB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it belongs to the ADP-ribosylglycohydrolase family, lacks the metal-binding and substrate-binding residues, suggesting that it has no hydrolase activity.
messages: Belongs to the ADP-ribosylglycohydrolase family.
messages: Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity).
messages: sarcomere

7955:med30
gene id: 7955:med30
uniprot id: A0A8M3AKI7
uniprot id: Q6PC45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

7955:akr1a1a
gene id: 7955:akr1a1a
uniprot id: Q6AZW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Displays no reductase activity towards retinoids (By similarity).
messages: cytosol

7955:si:dkey-73n8.3
gene id: 7955:si:dkey-73n8.3
uniprot id: A0A0R4IWU8
uniprot id: A0A8M1NXM3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:pcdh2g13
gene id: 7955:pcdh2g13
uniprot id: I6LD61
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:or109-5
gene id: 7955:or109-5
uniprot id: Q2PRJ9
names: Subcellular Location Annotation
messages: Membrane

7955:pcdh2ab3
gene id: 7955:pcdh2ab3
uniprot id: Q60I74
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:dhrs11b
gene id: 7955:dhrs11b
uniprot id: A0A8M1MZZ0
uniprot id: F1R5X7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:gnb4a
gene id: 7955:gnb4a
uniprot id: A0A8M9NZA4
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

7955:r3hdml
gene id: 7955:r3hdml
uniprot id: E7EZY0
names: Similarity
messages: Belongs to the CRISP family.

7955:pik3r1
gene id: 7955:pik3r1
uniprot id: A0A8M2BCX6
uniprot id: A0A8M2BCY4
uniprot id: A0A8M2BD59
uniprot id: B0S6V6
uniprot id: B0S6V7
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

7955:nppa
gene id: 7955:nppa
uniprot id: A0A8M1PDR2
uniprot id: F1QVW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

7955:man2a2
gene id: 7955:man2a2
uniprot id: A0A8M3AWC8
uniprot id: A0A8M3B6Z4
uniprot id: E7EYL2
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

7955:si:dkey-58f10.6
gene id: 7955:si:dkey-58f10.6
uniprot id: A0A2R8Q813
uniprot id: A0A8M1P3H3
uniprot id: A0A8M9Q3M1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:cabz01076234.2
gene id: 7955:cabz01076234.2
uniprot id: A0A8M6Z1L0
uniprot id: A0A8M9PP89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

7955:LOC568866
gene id: 7955:LOC568866
uniprot id: A0A8N7TBP6
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:tpcn2
gene id: 7955:tpcn2
uniprot id: A0JMD4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
messages: Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity).
messages: Homodimer (By similarity).
messages: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis.
messages: Late endosome membrane
messages: Lysosome membrane
messages: N-glycosylated.

7955:marveld2a
gene id: 7955:marveld2a
uniprot id: F1QIE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

7955:slc30a5
gene id: 7955:slc30a5
uniprot id: Q6DG36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: COPII-coated vesicle membrane
messages: Golgi stack membrane
messages: Heterodimer with SLC30A6/ZNT6; form a functional zinc ion transmembrane transporter.
messages: Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis.
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

7955:efna5b
gene id: 7955:efna5b
uniprot id: B3DH39
uniprot id: P79728
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor epha2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation (By similarity). Controls axon growth and may be involved in the creation of the retino-tectal map.
messages: Expressed in the presumptive midbrain of developing embryos from the six-somite stage. By 24 hours, strongly expressed in the midbrain caudal to the presumptive tectum. At later stages, maintained at the posterior margin of the tectum.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Widespread expression in the embryo.

7955:dkk2
gene id: 7955:dkk2
uniprot id: A8KB56
names: Similarity
messages: Belongs to the dickkopf family.

7955:scocb
gene id: 7955:scocb
uniprot id: A0A0H2UKD1
uniprot id: A0A8M1N2N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

7955:renbp
gene id: 7955:renbp
uniprot id: A0A8M1NHG0
uniprot id: B0S6K7
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

7955:cpeb2
gene id: 7955:cpeb2
uniprot id: A0A8M1RRV8
uniprot id: A0A8M2BLD1
uniprot id: A0A8M3AMK6
uniprot id: A0A8M9PKW6
names: Similarity
messages: Belongs to the RRM CPEB family.

7955:bco2b
gene id: 7955:bco2b
uniprot id: Q1RLW1
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

7955:olfcg3
gene id: 7955:olfcg3
uniprot id: A0A0R4I9L6
uniprot id: A0A0R4IBV4
uniprot id: A0A8M1NEX5
uniprot id: A0A8M3AJN2
uniprot id: A0A8M6YTF1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:LOC100535338
gene id: 7955:LOC100535338
uniprot id: A0A2R8QPY7
uniprot id: A0A8M2BFZ0
names: Subcellular Location Annotation
messages: Nucleus

7955:pdzk1ip1
gene id: 7955:pdzk1ip1
uniprot id: Q90X36
names: Subcellular Location Annotation
messages: Membrane

7955:tmem131l
gene id: 7955:tmem131l
uniprot id: A0A8M2BI51
uniprot id: A0A8M3AI58
uniprot id: A0A8N7UVD8
names: Similarity
messages: Belongs to the TMEM131 family.

7955:LOC100332745
gene id: 7955:LOC100332745
uniprot id: A0A8M9PIP8
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:apoa1a
gene id: 7955:apoa1a
uniprot id: O42363
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein A1/A4/E family.
messages: Highly expressed in the yolk syncytial layer during embryonic (starting at the gastrula stage) and early larval development, an extraembryonic structure implicated in embryonic and larval nutrition.
messages: Homodimer (By similarity). Interacts with NAXE and YJEFN3 (PubMed:23719382).
messages: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).
messages: Secreted

7955:tsc22d1
gene id: 7955:tsc22d1
uniprot id: A0A8M1P4E3
uniprot id: A0A8M1P8T9
uniprot id: B0V1G3
uniprot id: Q6NWA6
uniprot id: Q7SZP1
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

7955:si:dkey-82j4.2
gene id: 7955:si:dkey-82j4.2
uniprot id: A0A8M9PY01
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

7955:zgc:123068
gene id: 7955:zgc:123068
uniprot id: Q6IEC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

7955:npy8br
gene id: 7955:npy8br
uniprot id: O57463
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7955:ulk3
gene id: 7955:ulk3
uniprot id: A4IG43
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:LOC103910107
gene id: 7955:LOC103910107
uniprot id: A0A8M3B7W6
uniprot id: A0A8M9PAL6
uniprot id: A0A8M9PG16
names: Similarity
messages: Belongs to the NLRP family.

7955:ric8a
gene id: 7955:ric8a
uniprot id: A0A8M2BA40
uniprot id: A9JTE4
uniprot id: E7F1K0
uniprot id: Q642H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cell membrane
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma (By similarity).
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

7955:pimr55
gene id: 7955:pimr55
uniprot id: A0A8M9PNA7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:si:ch211-113a14.19
gene id: 7955:si:ch211-113a14.19
uniprot id: E7EXD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:eif2d
gene id: 7955:eif2d
uniprot id: Q7SXY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

7955:pimr214
gene id: 7955:pimr214
uniprot id: A0A8M3ARC8
uniprot id: A0A8M9Q121
uniprot id: A0A8M9QBU5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.

7955:ywhae2
gene id: 7955:ywhae2
uniprot id: A0A8M9Q1K3
uniprot id: B2GRG9
uniprot id: Q5CZQ1
names: Similarity
names: Subunit
messages: Belongs to the 14-3-3 family.
messages: Homodimer, and heterodimer with other family members.

7955:porcn
gene id: 7955:porcn
uniprot id: A0A8M1NJL6
uniprot id: A0A8M3B1X0
uniprot id: B0S7W7
names: Subcellular Location Annotation
messages: Membrane

7955:LOC100334198
gene id: 7955:LOC100334198
uniprot id: E7EZI4
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto protein substrates.
messages: Probably maternally supplied, the zygotic expression is detected early during development at the 512-cell stage and is stable until 24h hpf at least.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:mab21l1
gene id: 7955:mab21l1
uniprot id: Q6NYB4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mab-21 family.
messages: Expressed from 8 hours post-fertilization (hpf). Expressed in the midbrain and the optic primordia from 14 hpf and around the eyes, the branchial pouches and the neural tube at 24 hpf. By 48 hpf, expression in the midbrain, branchial pouches and the neural tube was reduced to a very low level.
messages: Monomer. Homodecamer; composed of 2 back to back homopentamers. The protein may exist as monomer in solution and oiligomerizes upon ligand binding.
messages: Nucleus
messages: Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity).

7955:ube2d1a
gene id: 7955:ube2d1a
uniprot id: Q7SXH5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:zmp:0000000755
gene id: 7955:zmp:0000000755
uniprot id: A0A8M9QAQ5
uniprot id: A0A8M9QG63
uniprot id: A0A8M9QKD9
uniprot id: A0A8M9QNY9
names: Similarity
messages: Belongs to the PACS family.

7955:farsa
gene id: 7955:farsa
uniprot id: Q1JPX3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Cytoplasm
messages: Heterotetramer; dimer of two heterodimers formed by alpha and beta subunits.

7955:efhb
gene id: 7955:efhb
uniprot id: A0A8M1NYK5
uniprot id: E7F7T9
names: Subcellular Location Annotation
messages: cilium axoneme

7955:cnfn
gene id: 7955:cnfn
uniprot id: A0A8M6YTL9
uniprot id: F1R0G8
names: Similarity
messages: Belongs to the cornifelin family.

7955:si:dkey-261e22.4
gene id: 7955:si:dkey-261e22.4
uniprot id: B3DGJ2
names: Similarity
messages: Belongs to the OCC1 family.

7955:eef1b2
gene id: 7955:eef1b2
uniprot id: Q7ZV16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

7955:epha4a
gene id: 7955:epha4a
uniprot id: A0A8M2BIL4
uniprot id: A0A8M2BIL7
uniprot id: A0A8M2BIM5
uniprot id: A0A8M2BJ36
uniprot id: A0A8M3AQD5
uniprot id: Q5ZEW1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

7955:ccsapb
gene id: 7955:ccsapb
uniprot id: Q6P3G4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSAP family.
messages: Expressed both maternally and zygotically. Expressed ubiquitously in the developing embryo. Strongly expressed in the somites and brain at 16 to 26 hours post-fertilization (hpf).
messages: Plays a role in embryonic development, including proper left-right asymmetry formation. Also required for proper cilia beating (PubMed:22493317). Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (By similarity).
messages: axon
messages: centriole
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body
messages: cytoskeleton
messages: spindle

7955:si:ch211-266i6.3
gene id: 7955:si:ch211-266i6.3
uniprot id: A0A8M9QCL0
uniprot id: A0A8N7T866
uniprot id: E7F392
names: Similarity
messages: Belongs to the CKAP2 family.

7955:ackr4b
gene id: 7955:ackr4b
uniprot id: A0A8M2B9G9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:b4galt1
gene id: 7955:b4galt1
uniprot id: Q567N4
names: Subcellular Location Annotation
messages: Membrane

7955:LOC108191559
gene id: 7955:LOC108191559
uniprot id: A0A8M6Z8K5
uniprot id: F1QRS2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:zgc:113363
gene id: 7955:zgc:113363
uniprot id: A0A8M9Q9U4
uniprot id: A0A8N7UYV5
uniprot id: B0V1R0
names: Similarity
messages: Belongs to the MDFI family.

7955:atp6v1c1a
gene id: 7955:atp6v1c1a
uniprot id: B2GPU0
uniprot id: Q7T385
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

7955:rock1
gene id: 7955:rock1
uniprot id: A0A0R4IVY5
uniprot id: A0A8M9PRV2
uniprot id: H6U1H5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

7955:egf
gene id: 7955:egf
uniprot id: A0A8M2B432
uniprot id: A0A8M9PZ53
uniprot id: A0A8M9QAZ6
uniprot id: Q6VQA2
names: Caution
names: Function
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
messages: Interacts with EGFR and promotes EGFR dimerization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pin4
gene id: 7955:pin4
uniprot id: B2GQB4
uniprot id: Q503Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
messages: Cytoplasm
messages: May be involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to DNA (By similarity).
messages: nucleolus
messages: spindle

7955:sf3b5
gene id: 7955:sf3b5
uniprot id: Q6DGK8
uniprot id: Q6ZM78
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

7955:si:ch73-281i18.7
gene id: 7955:si:ch73-281i18.7
uniprot id: A0A0R4INY9
uniprot id: A0A8M1RT81
names: Similarity
messages: Belongs to the MAP7 family.

7955:cfap157
gene id: 7955:cfap157
uniprot id: A2BDR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP157 family.
messages: Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility.
messages: cilium basal body

7955:atp6v0ca
gene id: 7955:atp6v0ca
uniprot id: F1QSP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

7955:pabpc1a
gene id: 7955:pabpc1a
uniprot id: F1QB54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA (By similarity). Prevents mRNA deadenylation and confers poly(A) stability (By similarity). Binds to N6-methyladenosine (m6A)-containing mRNAs (By similarity). Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl (By similarity). Involved in the maternal-to-zygotic transition in early embryo via interaction with ybx1: interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing maternal mRNAs, preventing their degradation (PubMed:31399345).
messages: Cytoplasm
messages: Interacts with ybx1; interaction recruits pabpc1a on C5-methylcytosine (m5C)-containing mRNAs, preventing their degradation.
messages: RRM4, together with the C- and N-terminal regions, is sufficient for RNA-binding. RRM 1 has no RNA-binding activity itself, but improves discrimination between poly(A) and poly(U) in combination with the other repeats.

7955:fpr1
gene id: 7955:fpr1
uniprot id: A0A8M1RFG5
uniprot id: E7FF45
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:isl2b
gene id: 7955:isl2b
uniprot id: A0A8M9QGM0
uniprot id: P53407
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in the regional specification of the myotome and also in target recognition by the caudal primary neuron.
messages: Expressed both maternally and zygotically. At 17 hours post-fertilization (hpf), expressed in dorsal Rohan-Beard neurons and strongly in the ventral myotomes. At 24 hpf, head expression is restricted to eyes, the tectal region of the midbrain, trigeminal ganglia and the ganglia anterior to the otic vesicles.
messages: Nucleus

7955:rnf144ab
gene id: 7955:rnf144ab
uniprot id: Q6DH94
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBR family. RNF144 subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes ube2l3 and ube2l6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
messages: Membrane

7955:chst1
gene id: 7955:chst1
uniprot id: A0A8M9PMP6
uniprot id: Q6DBY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan.

7955:ppip5k1a
gene id: 7955:ppip5k1a
uniprot id: A0A8M9PQ41
uniprot id: A0A8M9Q2S4
uniprot id: A0A8M9Q8X0
uniprot id: A0A8M9QD12
uniprot id: A0A8M9QI11
uniprot id: A0A8N7UVM3
uniprot id: E7FFN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

7955:LOC100333801
gene id: 7955:LOC100333801
uniprot id: A0A8M2BJH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

7955:akt2
gene id: 7955:akt2
uniprot id: A0JMK1
uniprot id: Q8UUX0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

7955:cryabb
gene id: 7955:cryabb
uniprot id: A0A8M9Q8E3
uniprot id: Q6DG35
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

7955:man1a2
gene id: 7955:man1a2
uniprot id: B0V2X9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

7955:LOC100333863
gene id: 7955:LOC100333863
uniprot id: A0A8M2BGY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:erh
gene id: 7955:erh
uniprot id: Q98874
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the E(R) family.
messages: Homodimer.
messages: May have a role in the cell cycle.
messages: Nucleus

7955:ptk2aa
gene id: 7955:ptk2aa
uniprot id: Q7T2V4
names: Subcellular Location Annotation
messages: Cell membrane
messages: focal adhesion

7955:sema3gb
gene id: 7955:sema3gb
uniprot id: A0A2R9YJJ7
uniprot id: A0A8M2BEH4
uniprot id: B0S5G6
uniprot id: Q5ID21
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:spop
gene id: 7955:spop
uniprot id: A7YYH8
uniprot id: Q7T330
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tdpoz family.
messages: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
messages: Homodimer. Part of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain CUL3 and SPOP, plus a target protein (By similarity).
messages: Nucleus
messages: Nucleus speckle
messages: The BTB (POZ) domain mediates dimerization and interaction with CUL3.
messages: The MATH domain mediates interaction with protein-ubiquitin ligase substrates.

7955:naa10
gene id: 7955:naa10
uniprot id: B2GRA5
uniprot id: Q7T3B8
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

7955:bida
gene id: 7955:bida
uniprot id: Q1LX52
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

7955:plp2
gene id: 7955:plp2
uniprot id: A0A8M1NRM3
uniprot id: A0A8M2BEQ6
uniprot id: B0S6H4
names: Subcellular Location Annotation
messages: Membrane

7955:syndig1l
gene id: 7955:syndig1l
uniprot id: B7ZVK3
uniprot id: Q5TZE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD225/Dispanin family.
messages: Membrane
messages: cis-Golgi network

7955:apela
gene id: 7955:apela
uniprot id: P0DMC2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Elabela/Toddler family.
messages: Endogenous ligand for the apelin receptor (aplnra and/or aplnrb) (PubMed:24316148, PubMed:24407481). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:24316148, PubMed:24407481, PubMed:26017639, PubMed:29117894). Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor (PubMed:24316148, PubMed:24407481, PubMed:29117894). Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells (PubMed:24316148, PubMed:24407481). May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (PubMed:26017639). Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Involved in cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity).
messages: Expressed from the mid-blastula transition (MBT) to 3 days post-fertilization (dpf) (PubMed:24316148). Ubiquitously expressed in dividing cells of the blastoderm before becoming restricted after gastrulation to axial structures, with most prominent expression in the neural tube (PubMed:24316148).
messages: Expressed ubiquitously during late blastula and gastrula stages and becomes restricted to the lateral mesoderm, endoderm, and anterior and posterior notochord after gastrulation (PubMed:24407481).
messages: Interacts with aplnra and aplnrb (PubMed:24316148).
messages: Secreted
messages: Was named Toddler based on the phenotype.
messages: Zinc-finger-nuclease (ZFN)- or TALEN-mediated apela gene inactivation induces embryonic lethality due to heart dysgenesis around 6 days post-fertilization (dpf) (PubMed:24316148, PubMed:24407481). Mutant embryos show cardiac dysplasia ranging from a rudimentary heart to no heart (PubMed:24316148, PubMed:24407481). Embryos have minimal blood circulation, with an excess of erythrocytes accumulating at the intermediate cell mass (ICM) (PubMed:24316148, PubMed:24407481). Larvae display variable posterior truncations and, at times, tailbud duplications (PubMed:24316148). Posterior tissue defects range from loss of the ventral fin to complete tail and trunk truncations (PubMed:24316148). Embryos also display malformed pharyngeal endoderm, abnormal left-right positioning and formation of the liver (PubMed:24407481). By mid-gastrulation, embryos show reduced endodermal cell numbers and endodermal and mesodermal progenitor cell migration toward the animal pole (PubMed:24316148, PubMed:24407481). CRISPR-induced apela null mutations show also reduced endodermal cell numbers, increased rates of endodermal cells death and reduced endodermal and mesodermal cell migration at mid-gastrulation (PubMed:29117894). Show a strong decrease in the angioblast migration to the embryonic midline during late gastrulation (PubMed:26017639).
messages: extracellular space

7955:zgc:101559
gene id: 7955:zgc:101559
uniprot id: Q5U3W4
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

7955:zgc:172076
gene id: 7955:zgc:172076
uniprot id: A8WFZ6
names: Caution
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:her1
gene id: 7955:her1
uniprot id: Q90463
names: Subunit
messages: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.

7955:calb1
gene id: 7955:calb1
uniprot id: A0A8M1PUZ3
uniprot id: E9QJF8
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

7955:gig2d
gene id: 7955:gig2d
uniprot id: F2WZ28
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:grk4
gene id: 7955:grk4
uniprot id: A0A8M3BE02
uniprot id: Q08CJ6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

7955:frem2a
gene id: 7955:frem2a
uniprot id: B6IDE6
uniprot id: D7PS91
names: Similarity
messages: Belongs to the FRAS1 family.

7955:si:zfos-464b6.2
gene id: 7955:si:zfos-464b6.2
uniprot id: A0A8M1RMQ8
uniprot id: A0A8M1RT75
uniprot id: E7FE65
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

7955:erf
gene id: 7955:erf
uniprot id: A0A8N7UY92
uniprot id: B7ZVP1
uniprot id: Q1LY54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:arpp19b
gene id: 7955:arpp19b
uniprot id: A0A8M3AZG3
uniprot id: Q7ZUT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

7955:tubb2
gene id: 7955:tubb2
uniprot id: Q4VBI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

7955:si:ch211-223p8.8
gene id: 7955:si:ch211-223p8.8
uniprot id: A0A8M1NRN1
uniprot id: B7ZD10
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

7955:pmch
gene id: 7955:pmch
uniprot id: C9W8C3
names: Function
messages: Plays a role in skin pigmentation by antagonizing the action of melanotropin alpha. Induces melanin concentration within the melanophores. May participate in the control of the hypothalamo-pituitary adrenal gland axis by inhibiting the release of ACTH.

7955:LOC100005640
gene id: 7955:LOC100005640
uniprot id: A0A8M9PS21
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:kif15
gene id: 7955:kif15
uniprot id: A0A8M1REI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: spindle

7955:tac3a
gene id: 7955:tac3a
uniprot id: E9QE01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

7955:igf1rb
gene id: 7955:igf1rb
uniprot id: A0A8M1PBN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:apol1
gene id: 7955:apol1
uniprot id: A0A8M2BIK2
uniprot id: A0A8M2BIK6
uniprot id: A0A8M2BJ26
uniprot id: Q7T131
names: Similarity
messages: Belongs to the apolipoprotein L family.

7955:plcb2
gene id: 7955:plcb2
uniprot id: A0A8M9P9T2
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

7955:LOC101882811
gene id: 7955:LOC101882811
uniprot id: A0A8M2BES4
names: Subcellular Location Annotation
messages: Membrane

7955:mrps27
gene id: 7955:mrps27
uniprot id: Q6AXL6
names: Subcellular Location Annotation
messages: Mitochondrion

7955:ube2e2
gene id: 7955:ube2e2
uniprot id: A7E2P0
uniprot id: Q6DG68
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:dsg2.1
gene id: 7955:dsg2.1
uniprot id: H2EQR6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). Required for embryogenesis, specifically for progression of epiboly and normal convergence-extension movements during gastrulation (PubMed:22235774).
messages: Expressed at fertilization and up to 2 hours post-fertilization (hpf), expression then declines to low levels at 4 hpf before increasing at 6 hpf onwards until 96 hpf.
messages: Morpholino knockdowns show increased embryonic lethality, with embryos that die developing one of two clear phenotypes following developmental arrest at 10 hpf (PubMed:22235774). The first group show severe epiboly arrest with the desmosomal cadherins and enveloping layer becoming detached from the external yolk syncytial layer that continues to undergo epiboly (PubMed:22235774). This results in a population of cells at the animal pole which maintain cell division and some gastrulation movements (PubMed:22235774). In the second phenotype the enveloping layer is attached to the yolk but does not progress through epiboly (PubMed:22235774). The enveloping layer remains attached in a ring to the base of the blastoderm until embryos arrest due to mechanical stress and detachment of the blastoderm from the yolk cell following extensive proliferation and blastoderm growth (PubMed:22235774). Embryos that survive to 14 hpf show morphological defects characteristic of altered gastrulation movements including a shorter embryonic axis, undulating notochord and somites that show either altered morphology or substantial disorganization (PubMed:22235774).
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
messages: desmosome

7955:si:dkey-26i13.5
gene id: 7955:si:dkey-26i13.5
uniprot id: A0A8M1Q1N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:zgc:158427
gene id: 7955:zgc:158427
uniprot id: A0A8M6Z2M4
uniprot id: A1A5Z1
uniprot id: Q1LVI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:eif3jb
gene id: 7955:eif3jb
uniprot id: B2GSG9
uniprot id: Q803P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c, eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and eif3m.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

7955:acot17
gene id: 7955:acot17
uniprot id: A0A8M9PHJ7
uniprot id: A0A8N1TRK1
uniprot id: A5PMN5
uniprot id: A7YYG3
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

7955:dlx5a
gene id: 7955:dlx5a
uniprot id: Q5XJL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

7955:fam199x
gene id: 7955:fam199x
uniprot id: Q6AXJ7
names: Similarity
messages: Belongs to the FAM199 family.

7955:dnajc27
gene id: 7955:dnajc27
uniprot id: Q6IMK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: GTPase possibly involved in regulation of the MEK/ERK pathway.
messages: Nucleus

7955:wtap
gene id: 7955:wtap
uniprot id: A0A8M2B7H8
uniprot id: Q7SXL7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing.
messages: Belongs to the fl(2)d family.
messages: Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. Component of the MACOM subcomplex.
messages: Maternally expressed from the 4-cell stage and ubiquitously expressed through early embryogenesis, with enriched expression in the brain region at 36 hpf (hours post fertilization).
messages: Multiple developmental defects at 24 hpf (hours post fertilization) including smaller head and eyes, smaller brain ventricle, and curved notochord.
messages: Nucleus speckle
messages: nucleoplasm

7955:trim2a
gene id: 7955:trim2a
uniprot id: A0A8M2BI61
uniprot id: A0A8M2BIL2
uniprot id: F1QFW2
uniprot id: Q58ER5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

7955:gphnb
gene id: 7955:gphnb
uniprot id: A0A8M9P2E8
uniprot id: A0A8M9PBI8
uniprot id: A0A8M9PBJ3
uniprot id: A0A8M9PH34
uniprot id: A0A8M9PP37
uniprot id: A0A8M9PP41
uniprot id: A0A8M9PSF7
uniprot id: A0A8M9PSG2
uniprot id: D3KYL2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

7955:kcnn1a
gene id: 7955:kcnn1a
uniprot id: A0A0R4INU5
uniprot id: A0A8M1NH91
uniprot id: A0A8M2BIK5
uniprot id: A0A8M2BIZ6
uniprot id: A0A8M9QA92
uniprot id: A0A8M9QNQ2
uniprot id: A0A8M9QNT3
names: Subcellular Location Annotation
messages: Membrane

7955:si:dkeyp-23e4.3
gene id: 7955:si:dkeyp-23e4.3
uniprot id: A0A2R8QK84
uniprot id: A0A8M2B8G9
uniprot id: A0A8N7T6F4
uniprot id: F1Q7X0
names: Subcellular Location Annotation
messages: Cytoplasm

7955:ptk2ba
gene id: 7955:ptk2ba
uniprot id: A0A8M2B4Z9
uniprot id: A0A8M2B5G2
uniprot id: K7DYJ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: focal adhesion

7955:h3f3c
gene id: 7955:h3f3c
uniprot id: B2GSF5
uniprot id: Q6PI20
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation. Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).
messages: Asymmetric dimethylation at Arg-18 (H3R17me2a) is linked to gene activation. Asymmetric dimethylation at Arg-3 (H3R2me2a) by prmt6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3' of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters (By similarity).
messages: Belongs to the histone H3 family.
messages: Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis.
messages: Chromosome
messages: Dopaminylated by TGM2 at Gln-6 (H3Q5dop) in ventral tegmental area (VTA) neurons (By similarity). H3Q5dop mediates neurotransmission-independent role of nuclear dopamine by regulating relapse-related transcriptional plasticity in the reward system (By similarity).
messages: Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.
messages: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
messages: Lysine deamination at Lys-5 (H3K4all) to form allysine only takes place on H3K4me3 and results in gene repression.
messages: Monoubiquitinated by rag1 in lymphoid cells, monoubiquitination is required for V(D)J recombination.
messages: Nucleus
messages: Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by aurkb mediates the dissociation of HP1 proteins (cbx1, cbx3 and cbx5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by map3k20 isoform 1, rps6ka5 or aurkb during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by prkcb is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by lsd1/kdm1a. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by kdm4c/jmjd2c. Phosphorylation at Tyr-42 (H3Y41ph) by jak2 promotes exclusion of cbx5 (HP1 alpha) from chromatin. Phosphorylation on Ser-32 (H3S31ph) is specific to regions bordering centromeres in metaphase chromosomes.
messages: Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).
messages: Serotonylated by TGM2 at Gln-6 (H3Q5ser) during serotonergic neuron differentiation (By similarity). H3Q5ser is associated with trimethylation of Lys-5 (H3K4me3) and enhances general transcription factor IID (TFIID) complex-binding to H3K4me3, thereby facilitating transcription (By similarity).
messages: Specific interaction of trimethylated form at 'Lys-36' (H3.3K36me3) with zmynd11 is mediated by the encapsulation of Ser-32 residue with a composite pocket formed by the tandem bromo-PWWP domains.
messages: Specifically enriched in modifications associated with active chromatin such as methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for tp53bp1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (cbx1, cbx3 and cbx5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120' (By similarity).
messages: Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with zmynd11; when trimethylated at 'Lys-36' (H3.3K36me3).
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

7955:popdc2
gene id: 7955:popdc2
uniprot id: A9JT76
uniprot id: Q6JWV8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the popeye family.
messages: Detectable at 4 hours post-fertilization (hpf), expression levels peaked at 24 hpf and gradually decreased afterwards. Expression become detectable when skeletal muscle differentiation commences at 14-16 somites with an anteropsterior gradient. Myocardial expression starts at 22 hpf in the forming heart tube and, at 24 hpf, is confined to differentiated cardiac muscles cells. At 24 hpf, is also expressed in the entire myotome. At 48 and 72 hpf, expression in the trunk muscle cells disappeares, but is present in muscles cells of the pectoral fin bud and facial muscles.
messages: Expressed in the heart and, slightly, in skeletal muscle.
messages: Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding.
messages: Membrane
messages: Morpholino knockdown of the protein affects skeletal muscle development, resulting in abnormal facial and trunk muscle formation with defective aligment of muscle fibers and establishment of myotendinous junctions. A severe defect is observed in craniofacial muscle development, where many muscles are malformed or reduced in size. In the heart, pericardial edema is prevalent in the morphants with defective looping and misshaped chambers.
messages: sarcolemma

7955:pkp1
gene id: 7955:pkp1
uniprot id: A0A8M9P5B3
names: Similarity
messages: Belongs to the beta-catenin family.

7955:nedd9
gene id: 7955:nedd9
uniprot id: Q08BB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

7955:prpf39
gene id: 7955:prpf39
uniprot id: Q1JPZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP39 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

7955:ppdpfa
gene id: 7955:ppdpfa
uniprot id: Q6PFP3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the PPDPF family.
messages: Expressed both maternally and zygotically. Expression increases between 1 dpf and 2 dpf when the exocrine pancreas starts to develop and is highest between 2 dpf and 5 dpf. Starts to express in the pancreatic area at 33 hpf. Later in development, the strongest domain of expression appears in the pancreas. Cells expressing are located about 1 somite anterior to the cluster of preproinsulin-positive cells, just before exocrine specification begins. By 36 hpf, expressing cells start to contact the preproinsulinpositive cells as a result of gut rotation. These expressing cells continue to grow posteriorly to form a typical pancreas-like shape at 3 dpf. From 33 hpf to 3 dpf, there is no overlap between expressing cells and preproinsulinpositive cells, indicating that expression is excluded from endocrine cells. Conversely, expression completely overlaps with trypsin expression at 3 dpf.
messages: Expressed exclusively in the exocrine cells during pancreas development.
messages: Expression is directly regulated by pancreas-specific transcription factor ptf1a. Probably also regulated by retinoic acid (RA).
messages: Impaired exocrine cell differentiation and growth. Loss or significant reduction of exocrine cells are due to lineage-specific cell cycle arrest but not apoptosis. The endocrine cell mass appear normal. Cell cycle arrest is mediated by up-regulation of cell cycle inhibitor genes cdkn1a, cdkn1b, and cyclin gccng1.
messages: Probable regulator of exocrine pancreas development.

7955:fam98a
gene id: 7955:fam98a
uniprot id: X1WEE6
names: Similarity
messages: Belongs to the FAM98 family.

7955:atl3
gene id: 7955:atl3
uniprot id: A0A8M2B438
uniprot id: A2CEM4
uniprot id: Q5XJ96
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

7955:fam150a
gene id: 7955:fam150a
uniprot id: A0A8M2BEE7
uniprot id: F8W2C9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ALKAL family.
messages: Cell membrane
messages: Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK (PubMed:29078341, PubMed:29317532). Required for iridophore development in the adult eye by acting as a receptor for LTK (PubMed:29078341).
messages: Expressed at low level in the notochord and iridophore stripes, the eye and the swim bladder.
messages: Fishes show reduced iridophores in eyes and operculum, with no detectable phenotype in the trunk (PubMed:29317532). Fishes lacking both alkal1 and alkal2b show a complete loss of eye iridophores (PubMed:29317532). Fishes lacking alkal1, alkal2a and alkal2b are embryonic lethal and display total loss of iridophores (PubMed:29317532).
messages: Secreted

7955:si:ch211-136a13.1
gene id: 7955:si:ch211-136a13.1
uniprot id: A0A8N7UV31
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:mtx1a
gene id: 7955:mtx1a
uniprot id: A2THY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:cetp
gene id: 7955:cetp
uniprot id: A0A8M3ARX3
uniprot id: Q5U3E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.
messages: Secreted

7955:cycsb
gene id: 7955:cycsb
uniprot id: Q6IQM2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Mitochondrion intermembrane space

7955:jag1a
gene id: 7955:jag1a
uniprot id: A0A8M2BFJ9
uniprot id: A0A8M2BFK4
uniprot id: B8JKQ5
uniprot id: Q90Y57
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

7955:csrnp1b
gene id: 7955:csrnp1b
uniprot id: A0A8M2B9M0
uniprot id: E9QH67
uniprot id: Q6PFK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

7955:rsrp1
gene id: 7955:rsrp1
uniprot id: A0A8M3AZF4
uniprot id: B8A501
names: Similarity
messages: Belongs to the RSRP family.

7955:unga
gene id: 7955:unga
uniprot id: A0A8M6Z6T9
uniprot id: Q7ZVD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

7955:pvalb6
gene id: 7955:pvalb6
uniprot id: Q804W1
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

7955:nck2a
gene id: 7955:nck2a
uniprot id: A0A8M9Q4I8
uniprot id: F1R1C3
uniprot id: Q803A2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

7955:me3
gene id: 7955:me3
uniprot id: A4QPA0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

7955:mtfp1
gene id: 7955:mtfp1
uniprot id: Q6PCS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFP1 family.
messages: Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity).
messages: Mitochondrion inner membrane

7955:or131-2
gene id: 7955:or131-2
uniprot id: B3DH96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer. Monomer.
messages: Probable olfactory receptor.

7955:slc15a2
gene id: 7955:slc15a2
uniprot id: B0S6T2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Cell membrane
messages: Detected at 1 to 7 days post-fertilization (dpf). Expressed in the forebrain and midbrain at 1 dpf, where it localizes to the ependymal cell layer of the dicephalic ventricle and midbrain ventricle. Expressed in the developing otic vesicle at 2-7 dpf, where it shows particularly strong expression in the epithelium of the semicircular canal projections.
messages: Expressed in kidney, brain and gut. Also expressed weakly in eye, gill and skeletal muscle.
messages: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides.

7955:gria3a
gene id: 7955:gria3a
uniprot id: A0A8M2BC92
uniprot id: A0A8M2BC95
uniprot id: A0A8M2BCD2
uniprot id: A0A8M2BCE2
uniprot id: A0A8M9Q861
uniprot id: A2CG69
uniprot id: Q71E61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

7955:gtf2h3
gene id: 7955:gtf2h3
uniprot id: A0A8M1NHH3
uniprot id: A5WWE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

7955:ghitm
gene id: 7955:ghitm
uniprot id: Q6NYV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

7955:chst2a
gene id: 7955:chst2a
uniprot id: A0A8N1TQ63
uniprot id: A5PM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

7955:rab18b
gene id: 7955:rab18b
uniprot id: Q6DHC1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Lipid droplet
messages: Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985).
messages: The most common abnormalities observed at 3 days post-fertilization are microphthalmia, microcephaly, pericardial edema, delayed jaw formation, a reduced overall body size, and a general developmental delay. Further characterization revealed that the rab18b morphants have delayed retinal development and abnormal retinal lamination, residual nucleated lens fiber cells, widely open choroid fissure, and microphthalmia at day 3.

7955:aebp1
gene id: 7955:aebp1
uniprot id: A0A8M1P8F5
uniprot id: E7F829
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

7955:cyp46a1.1
gene id: 7955:cyp46a1.1
uniprot id: A0A8M3AKM7
uniprot id: Q504G3
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:rab3il1
gene id: 7955:rab3il1
uniprot id: A0A8M9PH17
names: Similarity
messages: Belongs to the SEC2 family.

7955:pcid2
gene id: 7955:pcid2
uniprot id: F1QPP5
uniprot id: Q5U3P0
names: Similarity
messages: Belongs to the CSN12 family.

7955:atp9b
gene id: 7955:atp9b
uniprot id: A0A2R8PZC8
uniprot id: A0A8M1NAD0
uniprot id: A0A8M2BHD3
uniprot id: F1Q4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane
messages: trans-Golgi network membrane

7955:etfa
gene id: 7955:etfa
uniprot id: Q6IQL1
uniprot id: Q7ZUS9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

7955:cplx2l
gene id: 7955:cplx2l
uniprot id: Q6DHG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

7955:lrp13
gene id: 7955:lrp13
uniprot id: A0A8M9PJU9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC100331306
gene id: 7955:LOC100331306
uniprot id: A0A8M1RKL8
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:si:dkey-47k20.9
gene id: 7955:si:dkey-47k20.9
uniprot id: A0A8M1Q146
uniprot id: A0A8M3B317
uniprot id: F1R7V4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:LOC100534786
gene id: 7955:LOC100534786
uniprot id: A0A8M3B3T6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:si:ch1073-416d2.3
gene id: 7955:si:ch1073-416d2.3
uniprot id: A0A8M3AK66
names: Similarity
messages: Belongs to the serpin family.

7955:etv2
gene id: 7955:etv2
uniprot id: A0A2R8Q5A3
uniprot id: A0A8M2B541
uniprot id: Q30JB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:snrpd3l
gene id: 7955:snrpd3l
uniprot id: Q7ZVB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

7955:cyp2k16
gene id: 7955:cyp2k16
uniprot id: A0A0R4IQ63
uniprot id: A0A8M1N2L4
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:ddx54
gene id: 7955:ddx54
uniprot id: Q8JGR2
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.

7955:dynlt3
gene id: 7955:dynlt3
uniprot id: B2GQY4
uniprot id: Q6TGT3
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

7955:gaa
gene id: 7955:gaa
uniprot id: A0A8M1QKP5
uniprot id: A0A8M9PW57
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:kcnk5a
gene id: 7955:kcnk5a
uniprot id: Q32PR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

7955:LOC110437776
gene id: 7955:LOC110437776
uniprot id: A0A8M3B823
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:cntnap2a
gene id: 7955:cntnap2a
uniprot id: A0A8M3B6M0
uniprot id: L7NKH5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

7955:cct2
gene id: 7955:cct2
uniprot id: Q6PBW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

7955:degs2
gene id: 7955:degs2
uniprot id: A0A8M1NTC7
uniprot id: F1QW74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:prrc1
gene id: 7955:prrc1
uniprot id: Q5XJA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

7955:eme2
gene id: 7955:eme2
uniprot id: A0A8M9PG69
names: Similarity
messages: Belongs to the EME1/MMS4 family.

7955:si:ch211-210b2.4
gene id: 7955:si:ch211-210b2.4
uniprot id: A0A8M6YT66
uniprot id: X1WD01
names: Similarity
messages: Belongs to the TCAF family.

7955:acox1
gene id: 7955:acox1
uniprot id: A0A8M2BDM3
uniprot id: F1R071
uniprot id: Q5XIZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

7955:mmp14a
gene id: 7955:mmp14a
uniprot id: Q7T2J2
names: Similarity
messages: Belongs to the peptidase M10A family.

7955:cldnk
gene id: 7955:cldnk
uniprot id: Q6DBT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:flncb
gene id: 7955:flncb
uniprot id: A0A8M9PHR9
uniprot id: A0A8M9PHS4
uniprot id: A0A8M9PV09
uniprot id: A0A8M9PV14
uniprot id: A0A8M9Q104
uniprot id: A0A8M9Q107
uniprot id: A0A8M9Q696
uniprot id: A0A8M9Q6A0
uniprot id: A0A8M9QBS4
uniprot id: A0A8M9QBT0
uniprot id: F1QL44
names: Similarity
messages: Belongs to the filamin family.

7955:stmn1b
gene id: 7955:stmn1b
uniprot id: Q568Q7
names: Similarity
messages: Belongs to the stathmin family.

7955:gpx1b
gene id: 7955:gpx1b
uniprot id: A0A8M1N295
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7955:hcrtr2
gene id: 7955:hcrtr2
uniprot id: A1YQE3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:hsbp1b
gene id: 7955:hsbp1b
uniprot id: Q6PBV8
names: Similarity
messages: Belongs to the HSBP1 family.

7955:slc16a8
gene id: 7955:slc16a8
uniprot id: E7F4T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

7955:alk
gene id: 7955:alk
uniprot id: A0A8N7T7K6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

7955:tmem141
gene id: 7955:tmem141
uniprot id: Q0D285
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM141 family.
messages: Membrane

7955:cxcr2
gene id: 7955:cxcr2
uniprot id: A0A8M6Z0L3
uniprot id: F1Q8T9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:ccdc85cb
gene id: 7955:ccdc85cb
uniprot id: A0A8M2B759
uniprot id: Q6DHL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia (By similarity).
messages: adherens junction
messages: tight junction

7955:slc2a8
gene id: 7955:slc2a8
uniprot id: Q7ZWH3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

7955:prkar2b
gene id: 7955:prkar2b
uniprot id: A0A8M6Z4G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

7955:LOC108191006
gene id: 7955:LOC108191006
uniprot id: A0A8M9Q9V9
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:mthfd1l
gene id: 7955:mthfd1l
uniprot id: F1QQ79
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

7955:si:dkey-23a13.8
gene id: 7955:si:dkey-23a13.8
uniprot id: A0A8N7UVW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:zgc:175264
gene id: 7955:zgc:175264
uniprot id: A9ULS8
names: Subcellular Location Annotation
messages: Membrane

7955:LOC101884462
gene id: 7955:LOC101884462
uniprot id: A0A8M2B5T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

7955:sh3bp5lb
gene id: 7955:sh3bp5lb
uniprot id: A0A8N7TAP6
uniprot id: F1R096
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

7955:adam9
gene id: 7955:adam9
uniprot id: Q66IC3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:si:dkey-46a10.3
gene id: 7955:si:dkey-46a10.3
uniprot id: A8Y5U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIMOC1 family.
messages: Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A (By similarity). Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy (By similarity).
messages: cytosol

7955:arhgef3l
gene id: 7955:arhgef3l
uniprot id: A0A8M2B8W3
uniprot id: Q504F6
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

7955:chordc1b
gene id: 7955:chordc1b
uniprot id: Q7T3F7
names: Function
messages: Regulates centrosome duplication.

7955:pgfb
gene id: 7955:pgfb
uniprot id: A0A8M6Z2H3
uniprot id: X1WBL7
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

7955:tmeff1b
gene id: 7955:tmeff1b
uniprot id: Q4KMI9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:pcolce2a
gene id: 7955:pcolce2a
uniprot id: A0A8M3AZB2
uniprot id: X1WD58
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:sumo3b
gene id: 7955:sumo3b
uniprot id: F1QRX2
uniprot id: Q6DI05
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Cleavage of precursor form by a sentrin-specific protease is necessary for function.
messages: Cytoplasm
messages: Interacts with sae2 and ube2i. Covalently attached to a number of proteins (By similarity).
messages: Nucleus
messages: PML body
messages: Polymeric chains can be formed through Lys-11 cross-linking.
messages: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity).

7955:eva1c
gene id: 7955:eva1c
uniprot id: A0A8M3B3H0
uniprot id: A0A8M6Z8H0
uniprot id: E9QCY1
names: Similarity
messages: Belongs to the EVA1 family.

7955:psip1a
gene id: 7955:psip1a
uniprot id: A0A8M1N6J5
uniprot id: A0A8M2B6P0
uniprot id: A0A8M2B6P9
uniprot id: A0A8M3AH76
uniprot id: Q504G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

7955:tfdp1a
gene id: 7955:tfdp1a
uniprot id: Q803N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

7955:pdk2a
gene id: 7955:pdk2a
uniprot id: A0A8M9QJ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

7955:ypel1
gene id: 7955:ypel1
uniprot id: Q6AXK6
names: Similarity
messages: Belongs to the yippee family.

7955:fgf8b
gene id: 7955:fgf8b
uniprot id: B3DJ36
uniprot id: Q805B2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: May act as signaling molecule during development of the midbrain-hindbrain boundary (MHB) organizer, and be involved in patterning of the nervous system.
messages: Not expressed during gastrulation. First detected at the 8-somite stage in the ventral region of the MHB and in the anterior somites. At the 14-somite stage, expressed in the anteromedial margins of the somites and in the optic stalks. At 24 hours, expression is lost in the somites but observed in the otic vesicle. At 30 hours, expressed in the hyoid and at 36 hours in the dorsal diencephalon.
messages: Secreted

7955:atxn1a
gene id: 7955:atxn1a
uniprot id: Q1L966
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

7955:mixl1
gene id: 7955:mixl1
uniprot id: A0A8N7UZE4
uniprot id: Q5TYX1
names: Subcellular Location Annotation
messages: Nucleus

7955:si:ch211-113a14.7
gene id: 7955:si:ch211-113a14.7
uniprot id: Q561S9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:vps52
gene id: 7955:vps52
uniprot id: A0A0R4IY52
uniprot id: A0A8M3AK60
uniprot id: A0A8M9PSC6
names: Similarity
messages: Belongs to the VPS52 family.

7955:ebf2
gene id: 7955:ebf2
uniprot id: A0A8M2BCW5
uniprot id: A2BIQ0
uniprot id: B3DGS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

7955:tbx16
gene id: 7955:tbx16
uniprot id: O93389
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:rrp1
gene id: 7955:rrp1
uniprot id: A0A8M9QJV2
names: Similarity
messages: Belongs to the RRP1 family.

7955:fip1l1b
gene id: 7955:fip1l1b
uniprot id: A0A8M3AYF7
uniprot id: A0A8M3B4M9
uniprot id: B2GRL3
uniprot id: Q5XJD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Involved in mRNA processing.
messages: Nucleus

7955:zgc:86609
gene id: 7955:zgc:86609
uniprot id: A0A8M9QIK2
uniprot id: B0V1B5
uniprot id: D7R821
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

7955:mtmr2
gene id: 7955:mtmr2
uniprot id: A0JMK5
uniprot id: B2GSD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Early endosome membrane
messages: Homooligomer and heterooligomer.
messages: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).

7955:neu3.3
gene id: 7955:neu3.3
uniprot id: A0JMM3
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

7955:atg12
gene id: 7955:atg12
uniprot id: F5ATB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

7955:cenpp
gene id: 7955:cenpp
uniprot id: Q1LV50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-P/CTF19 family.
messages: Nucleus
messages: Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
messages: centromere

7955:prlh2
gene id: 7955:prlh2
uniprot id: A0A8M1RL72
uniprot id: A0A8M9PXU8
uniprot id: E7F496
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:gpr39
gene id: 7955:gpr39
uniprot id: Q7T298
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:ch211-194m7.4
gene id: 7955:si:ch211-194m7.4
uniprot id: A0A8M1RRZ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:dnaja2l
gene id: 7955:dnaja2l
uniprot id: Q7ZVS0
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch211-191d15.2
gene id: 7955:si:ch211-191d15.2
uniprot id: Q6DC82
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

7955:snx14
gene id: 7955:snx14
uniprot id: A0A8M2B751
uniprot id: A0A8N1YYQ3
uniprot id: E9QIC3
uniprot id: Q5PNP1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Late endosome membrane
messages: Loss of neural tissue volume: neuronal cell death is associated with impaired autophagic degradation.
messages: Lysosome membrane
messages: Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (PubMed:25848753). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).
messages: dendrite

7955:caskin1
gene id: 7955:caskin1
uniprot id: A0A8M3AQR6
uniprot id: A0A8M3AQS1
uniprot id: A0A8M3AR14
uniprot id: A0A8M3AR19
uniprot id: A0A8M3AY55
uniprot id: A0A8M3AY61
uniprot id: A0A8M3B138
uniprot id: A0A8M3B8E4
uniprot id: A0A8M3B8E9
uniprot id: A0A8M9Q5E2
names: Subcellular Location Annotation
messages: Cytoplasm

7955:ppil4
gene id: 7955:ppil4
uniprot id: A0A8M3ALA9
uniprot id: A0A8M3B3W8
uniprot id: A5PM92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

7955:psd3l
gene id: 7955:psd3l
uniprot id: A0A8M9PTT3
names: Subcellular Location Annotation
messages: ruffle membrane

7955:ndrg2
gene id: 7955:ndrg2
uniprot id: Q5PR98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation (By similarity).
messages: Cytoplasm

7955:tgfa
gene id: 7955:tgfa
uniprot id: A0A8M1NPL7
uniprot id: A0A8M2BDJ4
uniprot id: A0A8M3ATI5
uniprot id: A0A8M3B0K7
uniprot id: A0A8M3BAH4
uniprot id: Q7T011
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC103909653
gene id: 7955:LOC103909653
uniprot id: A0A8M9PFS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:hprt1
gene id: 7955:hprt1
uniprot id: Q7ZV49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

7955:azin1b
gene id: 7955:azin1b
uniprot id: Q801V3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

7955:zgc:77058
gene id: 7955:zgc:77058
uniprot id: Q6NXA8
names: Similarity
messages: Belongs to the UPF0461 family.

7955:rab27a
gene id: 7955:rab27a
uniprot id: Q4V8U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

7955:pemt
gene id: 7955:pemt
uniprot id: Q7ZVZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

7955:slc12a2
gene id: 7955:slc12a2
uniprot id: A0A0G2KTI4
uniprot id: A0A8M9PTH8
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the SLC12A transporter family.
messages: Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:31367042). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:31367042). Important for maintenance of endolymph volume in the otic vesicle, probably by regulating ion homeostasis (PubMed:19633174). Also plays a role in normal development of the swim bladder (PubMed:19633174).
messages: Cell membrane
messages: Expressed in the otic vesicle at 6 days post-fertilization, with highest expression in the developing semicircular canals (at protein level). Detected in the notochord at the tailbud stage. Expressed in somites, notochord and intermediate mesoderm during early somitogenesis. Expressed in the otic vesicle from 24 hours post-fertilization onwards.
messages: Homodimer.
messages: Inhibited by bumetanide.
messages: Membrane

7955:pcmtd1
gene id: 7955:pcmtd1
uniprot id: Q32PW8
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

7955:osbpl2b
gene id: 7955:osbpl2b
uniprot id: A0A8M2B8V1
uniprot id: Q7ZVL1
names: Similarity
messages: Belongs to the OSBP family.

7955:zdhhc22
gene id: 7955:zdhhc22
uniprot id: A0A8M1PSH3
uniprot id: A0A8M6YTD6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:ctsbb
gene id: 7955:ctsbb
uniprot id: A0A8M2B7X2
uniprot id: A4FUN3
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:idi1
gene id: 7955:idi1
uniprot id: A0A8M2B9B7
uniprot id: F1QVG2
uniprot id: Q4V8U6
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

7955:si:ch211-120p12.3
gene id: 7955:si:ch211-120p12.3
uniprot id: A0A2R8RXI8
uniprot id: A0A8M2B398
uniprot id: A0A8N7UQZ3
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

7955:zdhhc16a
gene id: 7955:zdhhc16a
uniprot id: A0A8M3BEN1
uniprot id: A0A8M6Z1M7
uniprot id: B8A4F0
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Expressed in the central nervous system (CNS) (PubMed:26663717). Expressed in the developing forebrain, and especially in the telencephalon (PubMed:26663717).
messages: Maternally expressed in the at four-cell stage. Highly expressed in the developing anterior neural plate since tailbud stage. During the segmentation period, 24 hour post fertilization (hpf), expression is still enriched in cell clusters at prosencephalon and mesencephalon.
messages: Membrane
messages: Morpholino knockdown of the protein causes malformation in telencephalon (PubMed:26663717). Impaired neural stem/progenitor cells (NSPCs) proliferation in the telencephalon (PubMed:26663717).
messages: Palmitoyl acyltransferase that mediates palmitoylation of proteins and is required during embryonic heart development. Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (PubMed:26663717).
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:snx19b
gene id: 7955:snx19b
uniprot id: A0A8N7TBU3
uniprot id: E7F2X4
names: Similarity
messages: Belongs to the sorting nexin family.

7955:ldlra
gene id: 7955:ldlra
uniprot id: A0A8M2BB14
uniprot id: E9QGD4
uniprot id: Q7ZZT0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ankrd13b
gene id: 7955:ankrd13b
uniprot id: A0A8M1N7F5
uniprot id: A0A8M6YT16
uniprot id: E7F2R4
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

7955:LOC567656
gene id: 7955:LOC567656
uniprot id: A0A0G2KM47
uniprot id: A0A8N7UTC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

7955:acot15
gene id: 7955:acot15
uniprot id: A0A8M3B1S6
uniprot id: Q08BS6
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

7955:cyb561
gene id: 7955:cyb561
uniprot id: A0A8N7UZ43
uniprot id: B3DFV4
uniprot id: F6PCI4
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

7955:foxb1a
gene id: 7955:foxb1a
uniprot id: O73779
names: Subcellular Location Annotation
messages: Nucleus

7955:igf2a
gene id: 7955:igf2a
uniprot id: Q9PUD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

7955:cyba
gene id: 7955:cyba
uniprot id: Q6PH62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

7955:abch1
gene id: 7955:abch1
uniprot id: A0A8M2B4Y5
uniprot id: A0A8N7T5J6
names: Subcellular Location Annotation
messages: Membrane

7955:runx3
gene id: 7955:runx3
uniprot id: Q9DEA0
names: Subcellular Location Annotation
messages: Nucleus

7955:ccbe1
gene id: 7955:ccbe1
uniprot id: A0A8M6YWX1
uniprot id: A0A8M9P3B9
uniprot id: A8WGB1
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CCBE1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Not expressed in blood or lymphatic endothelial cells, correlating spatially and temporally with the migration routes of endothelial cells that bud from the PCV, migrate in association with somite boundaries and seed the horizontal myoseptum region from where lymphatic precursors later migrate.
messages: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways.
messages: Restricted expression during development with expression in the pronephros and ventral mesenchyme at 24 hours post fertilization (hpf). By 36 hpf, expression is detected in discrete zones along each somitic boundary, between the PCV and the horizontal myoseptum, as well as along the horizontal myoseptum itself. At 48 hpf, expression is restricted along the horizontal myoseptum.
messages: Secreted

7955:zp2l1
gene id: 7955:zp2l1
uniprot id: A7MBW8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:slc38a11
gene id: 7955:slc38a11
uniprot id: A8KBL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Membrane
messages: Putative sodium-dependent amino acid/proton antiporter.

7955:slc27a2a
gene id: 7955:slc27a2a
uniprot id: Q4KMC7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:mdm4
gene id: 7955:mdm4
uniprot id: A0A8M2BK21
uniprot id: A0A8M2BKM9
uniprot id: F1QD25
uniprot id: X1WCV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

7955:cox11
gene id: 7955:cox11
uniprot id: A3KNN8
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

7955:tmsb1
gene id: 7955:tmsb1
uniprot id: A0A097
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

7955:nop56
gene id: 7955:nop56
uniprot id: Q6DRE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

7955:psph
gene id: 7955:psph
uniprot id: Q498V7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

7955:sfxn3
gene id: 7955:sfxn3
uniprot id: A1L257
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

7955:echdc2
gene id: 7955:echdc2
uniprot id: Q6NWF7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

7955:rmi1
gene id: 7955:rmi1
uniprot id: A0A8M9QDM9
uniprot id: B2GPA1
uniprot id: Q7ZVM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RMI1 family.
messages: Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

7955:slc17a9a
gene id: 7955:slc17a9a
uniprot id: A0A8M1PS49
uniprot id: E9QCB4
names: Subcellular Location Annotation
messages: Membrane

7955:serpinf2a
gene id: 7955:serpinf2a
uniprot id: A0A8N7T5R7
uniprot id: F6NQ58
names: Similarity
messages: Belongs to the serpin family.

7955:kiaa0907
gene id: 7955:kiaa0907
uniprot id: A0A8M2BH01
uniprot id: A0A8M2BH11
uniprot id: A0A8M3AJJ6
uniprot id: A0A8M3AR35
uniprot id: A0A8M3ATY7
uniprot id: A0A8M3B243
uniprot id: A0A8M9P7R6
uniprot id: F1QQM1
uniprot id: Q6NZ18
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KHDC4 family.
messages: Cytoplasm
messages: Interacts with PRPF19.
messages: Nucleus
messages: RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
messages: The C-terminal part is necessary for the interaction with the PRP19C/Prp19 complex/NTC/Nineteen complex.
messages: The KH domains mediate RNA-binding.

7955:tvp23b
gene id: 7955:tvp23b
uniprot id: Q4VBU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

7955:fam13b
gene id: 7955:fam13b
uniprot id: A0A8M1P9F6
uniprot id: A0A8M2BKE5
uniprot id: A0A8M2BKE9
uniprot id: A0A8M2BKG0
uniprot id: A0A8M2BKW0
uniprot id: E7FEF1
uniprot id: F1QI23
names: Similarity
messages: Belongs to the FAM13 family.

7955:gh1
gene id: 7955:gh1
uniprot id: Q1JQ34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

7955:cacna1ba
gene id: 7955:cacna1ba
uniprot id: A0A8M1NG24
uniprot id: A0A8M3ASG9
uniprot id: A0A8M3AZM5
uniprot id: A0A8M3B2I1
uniprot id: A0A8M3B9N2
uniprot id: A0A8M6YY83
uniprot id: A0A8M6Z0K7
uniprot id: A0A8M6Z6W1
uniprot id: A0A8M9PK68
uniprot id: A0A8M9PXL9
uniprot id: A0A8M9PXN1
uniprot id: A0A8M9Q3C7
uniprot id: A0A8M9Q3D8
uniprot id: A0A8M9Q8N7
uniprot id: A0A8M9Q8P2
uniprot id: A0A8M9QDZ5
uniprot id: A0A8M9QE01
uniprot id: A2BHF4
uniprot id: T2B1R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

7955:sart3
gene id: 7955:sart3
uniprot id: A0A8M1N775
uniprot id: B3DJT0
uniprot id: Q6ZM52
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cajal body
messages: Cytoplasm
messages: Nucleus speckle
messages: The egy mutant embryos that lack detectable sart3 expression display microcephaly, microphthalmia and die by 7 to 8 dpf. Pharyngeal arch formation is defective resulting in a thymus devoid of lymphocytes and exocrine pancreas development is also impaired.
messages: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:17416673). May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity).
messages: nucleoplasm

7955:atp5c1
gene id: 7955:atp5c1
uniprot id: A0A8M1P526
uniprot id: A0A8M1P9B7
uniprot id: Q5RH26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

7955:slco1d1
gene id: 7955:slco1d1
uniprot id: A0A8M9PU70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:nav2a
gene id: 7955:nav2a
uniprot id: A0A8M6Z7S7
uniprot id: A0A8M9PPF6
uniprot id: A0A8M9Q270
uniprot id: A0A8M9QCH2
names: Similarity
messages: Belongs to the Nav/unc-53 family.

7955:LOC100536670
gene id: 7955:LOC100536670
uniprot id: A0A8M9Q2Q8
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

7955:wnt9b
gene id: 7955:wnt9b
uniprot id: B6V3E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:poc1bl
gene id: 7955:poc1bl
uniprot id: Q5CZV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

7955:chia.3
gene id: 7955:chia.3
uniprot id: Q6NZZ8
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

7955:glp2r
gene id: 7955:glp2r
uniprot id: A0A8M3B4C0
names: Subcellular Location Annotation
messages: Membrane

7955:noto
gene id: 7955:noto
uniprot id: Q90461
names: Subcellular Location Annotation
messages: Nucleus

7955:dhx29
gene id: 7955:dhx29
uniprot id: A0A8N7T8I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC).

7955:sh3glb1a
gene id: 7955:sh3glb1a
uniprot id: A0A8M3AW37
uniprot id: Q568J6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Mitochondrion outer membrane

7955:rfx1b
gene id: 7955:rfx1b
uniprot id: A0A8M9Q7I5
uniprot id: A0A8M9QBM6
names: Subcellular Location Annotation
messages: Nucleus

7955:prdm4
gene id: 7955:prdm4
uniprot id: A0A8M1NI59
uniprot id: A0A8M6YZE3
uniprot id: F1R3R6
names: Subcellular Location Annotation
messages: Nucleus

7955:gngt2b
gene id: 7955:gngt2b
uniprot id: A0A8M1NYL7
uniprot id: E7F1F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:map2k4b
gene id: 7955:map2k4b
uniprot id: A0A8M2BK72
uniprot id: A0A8M9QIV0
uniprot id: A4UU31
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:erlin1
gene id: 7955:erlin1
uniprot id: Q58EG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.

7955:kcnj1a.4
gene id: 7955:kcnj1a.4
uniprot id: Q1LUW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:zgc:92912
gene id: 7955:zgc:92912
uniprot id: B2GRK6
uniprot id: Q6DGI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

7955:lsm14b
gene id: 7955:lsm14b
uniprot id: A0A8M1PE55
uniprot id: A8E580
uniprot id: F1Q898
names: Similarity
messages: Belongs to the LSM14 family.

7955:mov10b.1
gene id: 7955:mov10b.1
uniprot id: Q1LXK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body
messages: Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity).

7955:si:ch1073-174d20.1
gene id: 7955:si:ch1073-174d20.1
uniprot id: A0A8M1PRW2
uniprot id: A0A8M2BA81
uniprot id: E7FDE8
names: Similarity
messages: Belongs to the dysbindin family.

7955:cdh1
gene id: 7955:cdh1
uniprot id: Q90Z37
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

7955:slc25a38b
gene id: 7955:slc25a38b
uniprot id: A0A8M9Q680
uniprot id: P0CAT2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At 24 hours post-fertilization, expressed predominantly in posterior blood island, posterior cardinal vein and circulating blood. At 34 hours post-fertilization, becomes restricted to posterior blood island and circulating blood.
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Fishes lacking both slc25a38a and slc25a38b display anemia.
messages: May play a role as pro-apoptotic protein that induces caspase-dependent apoptosis.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane

7955:ryr3
gene id: 7955:ryr3
uniprot id: A0A8M3ALN1
uniprot id: A0A8M3ATC3
uniprot id: A0A8M3AWD0
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

7955:eno3
gene id: 7955:eno3
uniprot id: Q6TH14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

7955:LOC100332762
gene id: 7955:LOC100332762
uniprot id: A0A8M9Q2M1
uniprot id: A0A8M9Q7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

7955:si:ch211-231f6.6
gene id: 7955:si:ch211-231f6.6
uniprot id: A0A0R4II42
uniprot id: A0A8M2B9U8
uniprot id: A0A8M9PMH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSMST1 family.
messages: Membrane

7955:LOC103910251
gene id: 7955:LOC103910251
uniprot id: A0A8M6Z5H7
names: Subcellular Location Annotation
messages: Nucleus

7955:shank1
gene id: 7955:shank1
uniprot id: A0A8M9P8G4
uniprot id: A0A8M9PEY7
uniprot id: A0A8M9PJG1
uniprot id: A0A8M9PQE5
uniprot id: A0A8M9PQF3
uniprot id: A0A8M9PRS2
uniprot id: A0A8M9Q129
uniprot id: A0A8M9Q8Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cytoplasm
messages: Postsynaptic density

7955:gdpd5a
gene id: 7955:gdpd5a
uniprot id: A0A8M3AX60
uniprot id: A0A8N7T693
uniprot id: E7FGJ8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

7955:ogdha
gene id: 7955:ogdha
uniprot id: A0A0R4IP01
uniprot id: A0A8M1PDE6
uniprot id: A0A8M2BJN5
uniprot id: A0A8M2BJT5
uniprot id: A0A8M2BKA2
uniprot id: A0A8M3AVG6
uniprot id: B8JI08
uniprot id: F1Q5B8
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

7955:si:cabz01101003.1
gene id: 7955:si:cabz01101003.1
uniprot id: A0A8M1RR18
names: Subcellular Location Annotation
messages: centrosome
messages: perinuclear region

7955:tcp1
gene id: 7955:tcp1
uniprot id: Q6NYM0
uniprot id: Q9W792
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

7955:runx1
gene id: 7955:runx1
uniprot id: A0A8M9PJ75
uniprot id: Q78BK7
uniprot id: Q9DGB8
names: Subcellular Location Annotation
messages: Nucleus

7955:kcnj1a.1
gene id: 7955:kcnj1a.1
uniprot id: Q1L8I4
uniprot id: Q7SY43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:ppt1
gene id: 7955:ppt1
uniprot id: F1R8J6
uniprot id: Q7T3C4
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

7955:eif4ebp3
gene id: 7955:eif4ebp3
uniprot id: Q5U3D2
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

7955:si:ch211-251p5.5
gene id: 7955:si:ch211-251p5.5
uniprot id: E7FA22
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

7955:drgx
gene id: 7955:drgx
uniprot id: B3DHJ6
uniprot id: Q3BD88
names: Subcellular Location Annotation
messages: Nucleus

7955:ca6
gene id: 7955:ca6
uniprot id: A0A8M3ANQ1
uniprot id: E7F742
uniprot id: E9QB97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversible hydration of carbon dioxide. Its role in saliva is unknown.
messages: Secreted

7955:telo2
gene id: 7955:telo2
uniprot id: A0A2R8RJV5
uniprot id: A0A8M1N7E4
uniprot id: Q7T006
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEL2 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus
messages: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).

7955:col4a3bpa
gene id: 7955:col4a3bpa
uniprot id: A0A2R9YJF5
uniprot id: A0A8M1N5P3
uniprot id: F8W2V5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

7955:aoc1
gene id: 7955:aoc1
uniprot id: A0JMP5
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

7955:kdsr
gene id: 7955:kdsr
uniprot id: A0A8M1PE34
uniprot id: F1QWW8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:si:ch211-276f18.2
gene id: 7955:si:ch211-276f18.2
uniprot id: A0A8M3AZD1
uniprot id: E7FCE9
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

7955:sdha
gene id: 7955:sdha
uniprot id: B2GQ13
uniprot id: Q7ZVF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

7955:btbd10a
gene id: 7955:btbd10a
uniprot id: A0A8M2BAC2
uniprot id: A4IG48
names: Subcellular Location Annotation
messages: Cytoplasm

7955:arhgef1a
gene id: 7955:arhgef1a
uniprot id: A0A8M3B3E5
uniprot id: A0A8M9PN51
uniprot id: A0A8M9PRC8
uniprot id: A2RUX1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

7955:mrpl37
gene id: 7955:mrpl37
uniprot id: A3KP51
names: Subcellular Location Annotation
messages: Mitochondrion

7955:rab3aa
gene id: 7955:rab3aa
uniprot id: Q6DHJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

7955:mtg2
gene id: 7955:mtg2
uniprot id: A0A8M1PUH8
uniprot id: E9QCB3
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

7955:zc4h2
gene id: 7955:zc4h2
uniprot id: Q7T3I0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed throughout the developing central nervous system, but excluded from the most medial ventricular zone (PubMed:26056227).
messages: Larva with TALEN-induced zc4h2 null mutations show abnormally pectoral flexed fins, outward positioning of eyes, continuous swimming movements and balance problems at 5 days post-fertilization (dpf) (PubMed:26056227). Also exhibited an open mouth as well as continuous jaw movements (PubMed:26056227). Display a reduction in the number of V2 interneuron precursors in the hindbrain and spinal cord at 24 hours post-fertilization (hpf). Display a reduction in the number of GABAergic interneurons in the midbrain tegmentum at 35 hpf (PubMed:26056227).
messages: Nucleus
messages: Plays a role in GABAergic and V2 interneurons differentiation (PubMed:26056227). Involved in motoneuron development and in neuromuscular junction formation (PubMed:23623388).
messages: Postsynaptic cell membrane

7955:cacna1ha
gene id: 7955:cacna1ha
uniprot id: A0A8M3AR36
uniprot id: A0A8M3AY82
uniprot id: A0A8M3B162
uniprot id: A0A8M9PGJ8
uniprot id: A0A8M9Q5I3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

7955:LOC101883001
gene id: 7955:LOC101883001
uniprot id: A0A8M9PTG2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:ms4a17a.17
gene id: 7955:ms4a17a.17
uniprot id: A3KNL7
names: Similarity
messages: Belongs to the MS4A family.

7955:LOC796202
gene id: 7955:LOC796202
uniprot id: A0A8M9P965
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:zgc:171572
gene id: 7955:zgc:171572
uniprot id: A0A8M3B5A4
names: Similarity
messages: Belongs to the BicD family.

7955:tspan12
gene id: 7955:tspan12
uniprot id: A0A8M3AR77
uniprot id: Q7T2G0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:wnt3
gene id: 7955:wnt3
uniprot id: B0LK22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:foxp1b
gene id: 7955:foxp1b
uniprot id: A0A8M3ATJ4
uniprot id: A0A8M9PM82
uniprot id: A0A8M9PZW2
uniprot id: A0A8M9Q673
uniprot id: Q2LE08
names: Developmental Stage
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed both maternally and zygotically with continuous expression from the zygote to the early larva. Expression dramatically decreases at 30 and 50% epiboly stages, then increases from midgastrulaion onwards, being maintained at a high level until the protruding-mouth stage.
messages: Nucleus
messages: Shows complex and dynamic expression during early embryonic development. Prominent in many regions of the developing central nervous system, particularly in midbrain-hindbrain boundary, hindbrain and spinal cord. Strongly expressed in the retina, ear, branchial arches, hatching gland, heart, pronephric duct, gut, proctodeum, pectoral fin and swim bladder.
messages: The leucine-zipper is required for dimerization and transcriptional repression.
messages: Transcriptional repressor.

7955:rimbp2
gene id: 7955:rimbp2
uniprot id: A0A8M3AVH5
uniprot id: A0A8M9PRI7
names: Similarity
messages: Belongs to the RIMBP family.

7955:reep5
gene id: 7955:reep5
uniprot id: Q6PBX9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 60% of embryos die 7 days post-fertilization (PubMed:32075961). Embryos have cardiac developmental defects including a lack of cardiac looping and atrio-ventricular conduction defects with dysynchronous beating rhythms (PubMed:32075961). Increase in RTN4 protein expression levels (PubMed:32075961). Morpholino knockdown causes apparent sarcoplasmic reticulum membrane vacuolization in ventricular tissue along with structural discontinuity between sarcomeres (PubMed:32075961).
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in embryos 48 to 96 hours post-fertilization (at protein level) (PubMed:32075961). Expressed in both ventricular and atrial cardiomyocytes (at protein level) (PubMed:32075961).
messages: Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.
messages: Sarcoplasmic reticulum membrane
messages: The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes.

7955:aox5
gene id: 7955:aox5
uniprot id: M1ZMM0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Peroxisome

7955:loxhd1b
gene id: 7955:loxhd1b
uniprot id: A0A8M1QHF7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:mb
gene id: 7955:mb
uniprot id: Q6VN46
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

7955:grk5
gene id: 7955:grk5
uniprot id: A0A8M1NUN2
uniprot id: A0A8M9QKR0
uniprot id: A9JRC5
uniprot id: F1RAR9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

7955:ddc
gene id: 7955:ddc
uniprot id: Q7SZR0
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

7955:pkd1l2a
gene id: 7955:pkd1l2a
uniprot id: A0A2R8Q5E7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:si:ch211-26b3.4
gene id: 7955:si:ch211-26b3.4
uniprot id: A0A8M9P8U3
uniprot id: F1RA47
names: Similarity
messages: Belongs to the CNKSR family.

7955:mitfa
gene id: 7955:mitfa
uniprot id: A0A8M9Q5Y7
uniprot id: A0A8M9QF67
uniprot id: Q789G8
uniprot id: Q9PWC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

7955:efnb3a
gene id: 7955:efnb3a
uniprot id: A0A2R8RI02
uniprot id: A0A8N7TF59
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:rpn1
gene id: 7955:rpn1
uniprot id: Q8AYB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

7955:gpcpd1
gene id: 7955:gpcpd1
uniprot id: A0A8M3AWH0
uniprot id: A0A8M9PHA0
uniprot id: A0A8M9PSM9
uniprot id: Q1LVM1
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

7955:dynlrb1
gene id: 7955:dynlrb1
uniprot id: Q7ZUX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

7955:serpini1
gene id: 7955:serpini1
uniprot id: B3DJI9
names: Similarity
messages: Belongs to the serpin family.

7955:dda1
gene id: 7955:dda1
uniprot id: A9JT50
uniprot id: Q7T2A3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DDA1 family.
messages: Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1.
messages: Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.

7955:csnk2a1
gene id: 7955:csnk2a1
uniprot id: Q803N7
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:cfhl3
gene id: 7955:cfhl3
uniprot id: A0A8M9P476
uniprot id: A0A8M9PDT0
uniprot id: E2FHP7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:slx4ip
gene id: 7955:slx4ip
uniprot id: Q7T2B3
names: Similarity
messages: Belongs to the SLX4IP family.

7955:prdm14
gene id: 7955:prdm14
uniprot id: A0A8M2B9J9
uniprot id: F1QWQ9
uniprot id: Q6XSK8
names: Subcellular Location Annotation
messages: Nucleus

7955:fut7
gene id: 7955:fut7
uniprot id: Q32WF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

7955:elk4
gene id: 7955:elk4
uniprot id: A0A8M1P1J1
uniprot id: A0A8N1TTL1
uniprot id: F1QFL0
uniprot id: F1R0K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

7955:rpain
gene id: 7955:rpain
uniprot id: F1QKJ6
uniprot id: Q0P498
names: Subcellular Location Annotation
messages: Nucleus

7955:nadl1.2
gene id: 7955:nadl1.2
uniprot id: A0A8M2B9E7
uniprot id: A0A8M9PKJ8
uniprot id: Q6U7I4
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

7955:elovl8b
gene id: 7955:elovl8b
uniprot id: B8JJK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

7955:cyp2x9
gene id: 7955:cyp2x9
uniprot id: Q05AL5
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:aff4
gene id: 7955:aff4
uniprot id: A0A8M2BL85
uniprot id: A0A8M2BLK4
uniprot id: A0A8N7TEI3
uniprot id: I3ISK1
names: Similarity
messages: Belongs to the AF4 family.

7955:limk2
gene id: 7955:limk2
uniprot id: Q6DG29
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

7955:dnase1l1
gene id: 7955:dnase1l1
uniprot id: A0A8M1PNY3
uniprot id: F1QBE2
uniprot id: Q7SZQ1
names: Similarity
messages: Belongs to the DNase I family.

7955:sox11a
gene id: 7955:sox11a
uniprot id: A4QP08
uniprot id: Q9I9C8
names: Subcellular Location Annotation
messages: Nucleus

7955:polr1c
gene id: 7955:polr1c
uniprot id: Q6PHE7
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

7955:vetz
gene id: 7955:vetz
uniprot id: A0A0R4IYV3
uniprot id: A0A8M2BC19
uniprot id: A0A8M2BC40
uniprot id: A8WFS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

7955:zgc:91890
gene id: 7955:zgc:91890
uniprot id: Q6GMG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

7955:napaa
gene id: 7955:napaa
uniprot id: A4FVI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

7955:ddx4
gene id: 7955:ddx4
uniprot id: A0A8M6Z2W1
uniprot id: A0A8M6Z8Q8
uniprot id: A0A8M9PTC4
uniprot id: A0A8M9Q5S2
uniprot id: A0A8M9QBU4
uniprot id: A0A8M9QKJ0
uniprot id: O42107
uniprot id: Q8QGG8
names: Similarity
messages: Belongs to the DEAD box helicase family.

7955:cnot1
gene id: 7955:cnot1
uniprot id: A1A5H6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CNOT1 family.
messages: Component of the CCR4-NOT complex.
messages: Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity).

7955:LOC100537679
gene id: 7955:LOC100537679
uniprot id: A0A8M1RSY1
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

7955:scrib
gene id: 7955:scrib
uniprot id: Q4H4B6
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Expressed maternally during early embryonic stages. Initially expressed throughout the embryo then expression is restricted to the brain region.
messages: Palmitoylated.
messages: Postsynapse
messages: Presynapse
messages: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation.
messages: adherens junction
messages: lamellipodium

7955:fam13a
gene id: 7955:fam13a
uniprot id: A0A8M2B6Y2
uniprot id: A0A8M2B6Z1
uniprot id: A0A8M2B702
uniprot id: A0A8M3ASK9
uniprot id: A0A8M6YYR3
uniprot id: A0A8M9QBB9
uniprot id: A0A8N7T6Q1
names: Similarity
messages: Belongs to the FAM13 family.

7955:drd1b
gene id: 7955:drd1b
uniprot id: B6E506
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:tmem30c
gene id: 7955:tmem30c
uniprot id: A0A8M9QFA7
uniprot id: Q6PH05
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

7955:cept1a
gene id: 7955:cept1a
uniprot id: A0A8M1NPR8
uniprot id: A0A8M3AUZ0
uniprot id: A0A8M3BBM6
uniprot id: B8JLM0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

7955:mrto4
gene id: 7955:mrto4
uniprot id: Q568C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

7955:sema4c
gene id: 7955:sema4c
uniprot id: A0A8M2BFW5
uniprot id: A4JYS4
uniprot id: F1QF70
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:syne2b
gene id: 7955:syne2b
uniprot id: A0A8M9QAE9
uniprot id: A0A8M9QG37
names: Similarity
messages: Belongs to the nesprin family.

7955:si:ch211-236l14.4
gene id: 7955:si:ch211-236l14.4
uniprot id: A0A8M1RL95
uniprot id: F1Q8T6
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

7955:fahd2a
gene id: 7955:fahd2a
uniprot id: A0A8M9PQS6
uniprot id: A0A8M9Q3D7
uniprot id: A0A8M9Q9M2
uniprot id: A0A8M9QDP1
uniprot id: Q6NWI6
names: Similarity
messages: Belongs to the FAH family.

7955:pkd2l1
gene id: 7955:pkd2l1
uniprot id: A0A8N7UVH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane

7955:viml
gene id: 7955:viml
uniprot id: Q6PBS2
names: Function
names: Similarity
messages: Belongs to the intermediate filament family.
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

7955:cybb
gene id: 7955:cybb
uniprot id: Q7T2A7
names: Subcellular Location Annotation
messages: Membrane

7955:supt4h1
gene id: 7955:supt4h1
uniprot id: Q6DGQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Interacts with SUPT5H to form the DSIF complex. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (By similarity).
messages: May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity).
messages: Nucleus

7955:LOC101884284
gene id: 7955:LOC101884284
uniprot id: A0A8M9PLT0
names: Subcellular Location Annotation
messages: Cytoplasm

7955:opn4xa
gene id: 7955:opn4xa
uniprot id: A0A0N9P1E9
uniprot id: F1QZ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

7955:elovl2
gene id: 7955:elovl2
uniprot id: A3KP14
uniprot id: Q1RM84
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:slc35e2b
gene id: 7955:slc35e2b
uniprot id: A0A8M9QAA2
names: Subcellular Location Annotation
messages: Membrane

7955:si:dkey-56f14.4
gene id: 7955:si:dkey-56f14.4
uniprot id: A0A8M1NYK2
uniprot id: A0A8M1P3F5
uniprot id: X1WFJ3
uniprot id: X1WI05
names: Similarity
messages: Belongs to the FXYD family.

7955:LOC100335005
gene id: 7955:LOC100335005
uniprot id: A0A8M1RS95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

7955:si:ch211-186e20.7
gene id: 7955:si:ch211-186e20.7
uniprot id: F8W5D3
names: Similarity
messages: Belongs to the serpin family.

7955:slc26a3.2
gene id: 7955:slc26a3.2
uniprot id: Q1RLN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Chloride/bicarbonate exchanger.
messages: Membrane

7955:eif1axb
gene id: 7955:eif1axb
uniprot id: A9JT75
uniprot id: Q4V9N9
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

7955:fbn1
gene id: 7955:fbn1
uniprot id: A0A8M6YW17
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

7955:LOC563082
gene id: 7955:LOC563082
uniprot id: A0A8M2BKM7
uniprot id: E7FBR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

7955:si:rp71-1c23.3
gene id: 7955:si:rp71-1c23.3
uniprot id: A2BHB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (qrsl1), B (gatb) and C (gatc) subunits.

7955:wscd1b
gene id: 7955:wscd1b
uniprot id: A0A8M9Q6P9
uniprot id: E7F082
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Belongs to the sulfotransferase 1 family.
messages: Membrane

7955:pomgnt2
gene id: 7955:pomgnt2
uniprot id: A0A8M1N437
uniprot id: F1QAS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:calcrla
gene id: 7955:calcrla
uniprot id: Q68EK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) (By similarity). Receptor specificity may be modulated by accessory proteins. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).

7955:arg1
gene id: 7955:arg1
uniprot id: A0A8M1NA41
uniprot id: E7F8R4
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

7955:haus3
gene id: 7955:haus3
uniprot id: Q08CD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

7955:stx18
gene id: 7955:stx18
uniprot id: A0A8M3BEW8
uniprot id: Q4VBI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

7955:ern2
gene id: 7955:ern2
uniprot id: A0A8M1QQI8
uniprot id: A0A8M3B496
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

7955:acss2
gene id: 7955:acss2
uniprot id: A0A2R8Q6G5
uniprot id: A0A8M1P9T3
uniprot id: A0A8M2B8S0
uniprot id: F1QAA7
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

7955:pm20d1.1
gene id: 7955:pm20d1.1
uniprot id: Q32LT9
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Lipoproteins are powerful coactivators of PM20D1 activity in vitro and NAA biosynthesis in vivo.
messages: Secreted
messages: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles.

7955:cyp2aa3
gene id: 7955:cyp2aa3
uniprot id: B3DJ50
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:zdhhc14
gene id: 7955:zdhhc14
uniprot id: A0A8M1NA34
uniprot id: A0A8M2B765
uniprot id: A0A8M2B7H9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:wu:fa11c10
gene id: 7955:wu:fa11c10
uniprot id: A0A8M3B612
names: Similarity
messages: Belongs to the FAM110 family.

7955:LOC100537098
gene id: 7955:LOC100537098
uniprot id: A0A8M6YTJ6
uniprot id: A0A8M9PFL4
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:pex19
gene id: 7955:pex19
uniprot id: Q561W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

7955:grin2ab
gene id: 7955:grin2ab
uniprot id: F1QDE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

7955:gpx4a
gene id: 7955:gpx4a
uniprot id: A0A8M1N2T9
uniprot id: A0A8M1PAF3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

7955:fmn2a
gene id: 7955:fmn2a
uniprot id: A0A8M1PYR3
uniprot id: A0A8M9P0I6
uniprot id: X1WC43
names: Similarity
messages: Belongs to the formin homology family. Cappuccino subfamily.

7955:ddx11
gene id: 7955:ddx11
uniprot id: F1R345
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. Plays a role in DNA double-strand break (DSB) repair at the DNA replication fork during DNA replication recovery from DNA damage. Plays a role in the regulation of sister chromatid cohesion and mitotic chromosome segregation. Stimulates 5'-single-stranded DNA flap endonuclease activity of FEN1 in an ATP- and helicase-independent manner. Also plays a role in heterochromatin organization (By similarity). Involved in rRNA transcription activation through binding to active hypomethylated rDNA gene loci by recruiting UBTF and the RNA polymerase Pol I transcriptional machinery (PubMed:26089203). Plays a role in embryonic development (PubMed:26089203). Associates with chromatin at DNA replication fork regions. Binds to single- and double-stranded DNAs (By similarity).
messages: Midbody
messages: Morpholino knockdown of the protein leads to abnormal craniofacial and vertebrate development with shortened and twisted torsos, smaller eyes and low mouth positions at 3 days post-fertilization (dpf).
messages: Nucleus
messages: centrosome
messages: nucleolus
messages: spindle pole

7955:tdp1
gene id: 7955:tdp1
uniprot id: A0A8N7TC11
uniprot id: F8W5U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

7955:syf2
gene id: 7955:syf2
uniprot id: Q6DGP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing as component of the spliceosome.
messages: Nucleus

7955:si:dkey-88e18.8
gene id: 7955:si:dkey-88e18.8
uniprot id: A0A0R4ISE0
names: Similarity
messages: Belongs to the MINAR family.

7955:frrs1a
gene id: 7955:frrs1a
uniprot id: A0A8M9PSX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

7955:calm3a
gene id: 7955:calm3a
uniprot id: Q6PI52
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
messages: This protein has four functional calcium-binding sites.

7955:gpatch1
gene id: 7955:gpatch1
uniprot id: A0A8M1P3M2
uniprot id: A0JMC1
uniprot id: G1K2G6
names: Similarity
messages: Belongs to the GPATCH1 family.

7955:LOC100536119
gene id: 7955:LOC100536119
uniprot id: A0A8M9PM25
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-121 and Arg-124) that bind to malonylated and succinylated substrates and define the specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.
messages: Nucleus
messages: cytosol

7955:zgc:56525
gene id: 7955:zgc:56525
uniprot id: F1QI79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

7955:taar20c1
gene id: 7955:taar20c1
uniprot id: A0A8M3BDB5
uniprot id: H0WEH4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:fam193a
gene id: 7955:fam193a
uniprot id: A0A0R4ICL0
uniprot id: A0A8M1P4R5
names: Similarity
messages: Belongs to the FAM193 family.

7955:slc1a4
gene id: 7955:slc1a4
uniprot id: A0A8M1N0N2
uniprot id: D7RVS1
uniprot id: Q7ZZ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

7955:cadm1a
gene id: 7955:cadm1a
uniprot id: A0A8M1NF64
uniprot id: A0A8M2B864
uniprot id: A0A8M2B8F2
uniprot id: A0A8M3B4P4
uniprot id: A0A8M9PIE5
uniprot id: B0F6R0
names: Similarity
messages: Belongs to the nectin family.

7955:irf2bpl
gene id: 7955:irf2bpl
uniprot id: Q6P947
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

7955:si:ch211-219a4.6
gene id: 7955:si:ch211-219a4.6
uniprot id: A0A8M1PZD8
names: Similarity
messages: Belongs to the ARTD/PARP family.

7955:loxa
gene id: 7955:loxa
uniprot id: Q6NYT8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

7955:cry-dash
gene id: 7955:cry-dash
uniprot id: Q4KML2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) non-covalently per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function (By similarity). Has weak cyclobutyl pyrimidine photolyase activity when expressed in E.coli and when tested in vitro.

7955:zgc:110239
gene id: 7955:zgc:110239
uniprot id: A0A8M1N510
uniprot id: F1R9W6
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:sorcs2
gene id: 7955:sorcs2
uniprot id: A0A8M1RDM7
uniprot id: A0A8M3B1D9
uniprot id: A0A8M9PQ08
uniprot id: A0A8M9Q2P2
uniprot id: A0A8M9Q8U3
uniprot id: E7FD83
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

7955:tbl3
gene id: 7955:tbl3
uniprot id: Q5U3Q5
names: Subcellular Location Annotation
messages: nucleolus

7955:ube2l3a
gene id: 7955:ube2l3a
uniprot id: Q6IQK2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

7955:sdhaf3
gene id: 7955:sdhaf3
uniprot id: A0A8M1N249
uniprot id: A3KQK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

7955:gip
gene id: 7955:gip
uniprot id: A1DPK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

7955:mtfmt
gene id: 7955:mtfmt
uniprot id: A5PL71
uniprot id: A8E5A7
names: Similarity
messages: Belongs to the Fmt family.

7955:si:dkey-86l18.8
gene id: 7955:si:dkey-86l18.8
uniprot id: A0A8M1QLK8
uniprot id: F1QYE9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

7955:irx4b
gene id: 7955:irx4b
uniprot id: Q1LWG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

7955:gtf2h1
gene id: 7955:gtf2h1
uniprot id: Q66I03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

7955:pcdh2g17
gene id: 7955:pcdh2g17
uniprot id: I6LD65
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:strn4
gene id: 7955:strn4
uniprot id: A0A8M9PC77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

7955:tamm41
gene id: 7955:tamm41
uniprot id: Q3B7H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

7955:slc9a6b
gene id: 7955:slc9a6b
uniprot id: A9XPA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

7955:si:dkeyp-92c9.3
gene id: 7955:si:dkeyp-92c9.3
uniprot id: A0A286YBP3
uniprot id: A0A8M1NA99
uniprot id: A0A8M2BHG4
uniprot id: Q1LWT1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:irf1a
gene id: 7955:irf1a
uniprot id: A0A8M3AYR2
uniprot id: Q1RLP9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:LOC799481
gene id: 7955:LOC799481
uniprot id: A0A8M3AV27
names: Subcellular Location Annotation
messages: Nucleus

7955:rap2ab
gene id: 7955:rap2ab
uniprot id: A0A8M1NQC4
uniprot id: B8JIV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

7955:ergic3
gene id: 7955:ergic3
uniprot id: B2GQE2
uniprot id: Q803I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.
messages: Possible role in transport between endoplasmic reticulum and Golgi.
messages: cis-Golgi network membrane

7955:sdc4
gene id: 7955:sdc4
uniprot id: Q0JY12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Belongs to the syndecan proteoglycan family.
messages: Membrane

7955:aadacl4
gene id: 7955:aadacl4
uniprot id: A0A8M1NVX1
uniprot id: Q08B87
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

7955:ccr12b.1
gene id: 7955:ccr12b.1
uniprot id: A0A8M9PLY8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:pigv
gene id: 7955:pigv
uniprot id: A0A0R4ITR4
uniprot id: A0A8M1NWM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

7955:hrh2a
gene id: 7955:hrh2a
uniprot id: A0A2R8Q9U8
uniprot id: A0A8M1NAH7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:celf4
gene id: 7955:celf4
uniprot id: A0A8M3ALA7
uniprot id: A0A8M3ATP3
uniprot id: A0A8M3AWN6
uniprot id: A0A8M3B4J4
uniprot id: A0A8M6Z3M4
uniprot id: A0A8M9P396
uniprot id: A0A8M9PCL3
uniprot id: A0A8M9PQD3
uniprot id: A0A8M9PTS7
uniprot id: Q6DGV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus
messages: RNA-binding protein that may be implicated in the regulation of pre-mRNA alternative splicing.

7955:vipr2
gene id: 7955:vipr2
uniprot id: A7UH65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

7955:st13
gene id: 7955:st13
uniprot id: Q6NX98
names: Similarity
messages: Belongs to the FAM10 family.

7955:tom1
gene id: 7955:tom1
uniprot id: A0A8M1P5P3
uniprot id: A0A8M1P9P8
names: Similarity
messages: Belongs to the TOM1 family.

7955:ehd2a
gene id: 7955:ehd2a
uniprot id: A0A8M6Z771
uniprot id: E9QGV7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

7955:phactr3b
gene id: 7955:phactr3b
uniprot id: A0A8M3AXB9
uniprot id: A0A8M9PUW8
uniprot id: A0A8M9QHN5
uniprot id: Q504B7
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

7955:fam167ab
gene id: 7955:fam167ab
uniprot id: Q5RFZ7
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

7955:clcn7
gene id: 7955:clcn7
uniprot id: A0A8M2BB80
uniprot id: A0JMG8
uniprot id: F1QNP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

7955:zgc:153146
gene id: 7955:zgc:153146
uniprot id: F1QA34
uniprot id: Q0P4C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0602 family.
messages: centrosome

7955:prkcha
gene id: 7955:prkcha
uniprot id: B1H1I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

7955:mei4
gene id: 7955:mei4
uniprot id: Q5PNP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MEI4L family.
messages: Chromosome
messages: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination.

7955:crot
gene id: 7955:crot
uniprot id: Q503F8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

7955:si:ch211-113e8.5
gene id: 7955:si:ch211-113e8.5
uniprot id: A0A2R8QU83
uniprot id: A0A8M1P9D2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:LOC100536547
gene id: 7955:LOC100536547
uniprot id: A0A8M3BDA9
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:zgc:64201
gene id: 7955:zgc:64201
uniprot id: Q6PFS2
names: Similarity
messages: Belongs to the PRORSD1 family.

7955:nipblb
gene id: 7955:nipblb
uniprot id: A0A8M3B6H6
uniprot id: F1QBY1
names: Developmental Stage
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain (By similarity).
messages: Contaminating sequence. Potential poly-A sequence.
messages: Detected in the early blastula, 2.5 hours post fertilization (hpf), before the onset of zygotic gene expression, and expression progressively increases, reaching a peak at late gastrula stages (9 hpf), before decreasing by 26 hpf. Maternal transcripts are detected throughout the blastoderm. Ubiquitous expression continues until early somitogenesis (12 hpf), after which transcript levels gradually decrease in the trunk (15-18 hpf), with strong expression becoming restricted to the head by 25 hpf.
messages: May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading (PubMed:22039349). Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity).
messages: Nucleus

7955:kif1ab
gene id: 7955:kif1ab
uniprot id: A0A8M2BIG3
uniprot id: A0A8M3APQ1
uniprot id: A0A8M3AQ79
uniprot id: A0A8M3B098
uniprot id: A0A8M3B7Q1
uniprot id: A0A8M9P8Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

7955:or106-10
gene id: 7955:or106-10
uniprot id: A0A8M6Z8Z3
uniprot id: Q2PRK7
names: Subcellular Location Annotation
messages: Membrane

7955:sbf1
gene id: 7955:sbf1
uniprot id: A0A2R8PWA9
uniprot id: A0A8M2BBQ3
uniprot id: A0A8M2BBZ8
uniprot id: A0A8M3ARB7
uniprot id: A0A8M3ARJ8
uniprot id: A0A8M3AYP0
uniprot id: A0A8M3B8V9
uniprot id: F1QFF3
uniprot id: Q1LXZ0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

7955:ipmkb
gene id: 7955:ipmkb
uniprot id: A1A5W8
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

7955:stk17b
gene id: 7955:stk17b
uniprot id: Q6PHV6
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:LOC100334245
gene id: 7955:LOC100334245
uniprot id: A0A8M1RRR9
names: Similarity
messages: Belongs to the pellino family.

7955:ugt1a5
gene id: 7955:ugt1a5
uniprot id: A0A8M1NVN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:tead3a
gene id: 7955:tead3a
uniprot id: A0A2R8QCP0
uniprot id: A0A8M6YW14
uniprot id: A0A8M6Z3X5
uniprot id: A0A8M9PF88
uniprot id: A0A8M9PKY0
uniprot id: A0A8M9PTB3
uniprot id: A0A8M9PWP5
uniprot id: F1Q968
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

7955:rab42a
gene id: 7955:rab42a
uniprot id: Q6P977
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

7955:LOC794549
gene id: 7955:LOC794549
uniprot id: A3KPR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:myhz2
gene id: 7955:myhz2
uniprot id: Q6IQX1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

7955:tmem242
gene id: 7955:tmem242
uniprot id: Q4V8S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Mitochondrion inner membrane
messages: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.

7955:nid1a
gene id: 7955:nid1a
uniprot id: A0A8N7UUY5
uniprot id: F1RAG3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

7955:adgrd1
gene id: 7955:adgrd1
uniprot id: A0A8M9PR40
names: Subcellular Location Annotation
messages: Membrane

7955:mchr1b
gene id: 7955:mchr1b
uniprot id: A0A8N7TF54
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

7955:cap2
gene id: 7955:cap2
uniprot id: A0A0R4IXA9
uniprot id: Q5BJ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane

7955:chrna9
gene id: 7955:chrna9
uniprot id: A0A8M9PKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:c3a.4
gene id: 7955:c3a.4
uniprot id: A0A8M1RQR9
names: Subcellular Location Annotation
messages: Secreted

7955:LOC108183287
gene id: 7955:LOC108183287
uniprot id: A0A8M9Q651
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:siah2l
gene id: 7955:siah2l
uniprot id: A0A8M2BHM7
uniprot id: A0A8N1TYI4
uniprot id: G8JL17
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

7955:si:ch211-202h22.7
gene id: 7955:si:ch211-202h22.7
uniprot id: A0A8M9Q7M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

7955:actb1
gene id: 7955:actb1
uniprot id: Q7ZVI7
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
messages: Belongs to the actin family.
messages: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
messages: Methylation at His-73 by SETD3. Methylation stabilizes actin filaments.
messages: Nucleus
messages: Oxidation of Met-44 and Met-47 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization (By similarity).
messages: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (By similarity). Each actin can bind to 4 others (By similarity).
messages: Skeletal muscle, heart, gill, digestive tissue and brain (PubMed:9987040). Widespread expression throughout the brain, with highest levels in regions where neuronal proliferation is greatest (PubMed:9987040).
messages: cytoskeleton

7955:pms2
gene id: 7955:pms2
uniprot id: A0A8M9PWZ0
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

7955:tp73
gene id: 7955:tp73
uniprot id: A0A8M2BEL8
uniprot id: A0A8M3AVI5
uniprot id: B0S576
uniprot id: B0S577
uniprot id: Q801Z7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Nucleus

7955:reep1
gene id: 7955:reep1
uniprot id: A0A8M1PSF5
uniprot id: A0A8M9P9M3
uniprot id: F8W555
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:amn1
gene id: 7955:amn1
uniprot id: Q0P4D1
names: Similarity
messages: Belongs to the AMN1 family.

7955:tuba2
gene id: 7955:tuba2
uniprot id: Q6P972
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

7955:smc5
gene id: 7955:smc5
uniprot id: A0A8M1NV01
uniprot id: A0A8M2B1N5
uniprot id: E7F0W1
uniprot id: F1QEQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

7955:tomm40l
gene id: 7955:tomm40l
uniprot id: Q6NWH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

7955:jph2
gene id: 7955:jph2
uniprot id: A4QNV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

7955:si:dkeyp-50d11.2
gene id: 7955:si:dkeyp-50d11.2
uniprot id: A0A8M3AMD7
uniprot id: E9QFN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

7955:si:dkey-10f21.4
gene id: 7955:si:dkey-10f21.4
uniprot id: A0A8M1NG98
uniprot id: F1Q640
names: Subcellular Location Annotation
messages: Membrane

7955:mns1
gene id: 7955:mns1
uniprot id: A0A8M9Q801
uniprot id: E7FAR7
uniprot id: Q6PBA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MNS1 family.
messages: May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis (By similarity). Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity).
messages: Nucleus
messages: cilium axoneme
messages: flagellum axoneme

7955:si:dkey-246g23.4
gene id: 7955:si:dkey-246g23.4
uniprot id: A0A8M9PFG6
uniprot id: A0A8N1Z062
uniprot id: F1QHU5
names: Subcellular Location Annotation
messages: Membrane

7955:foxa3
gene id: 7955:foxa3
uniprot id: O73778
names: Subcellular Location Annotation
messages: Nucleus

7955:wnt6a
gene id: 7955:wnt6a
uniprot id: A0A8M1RQZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:nav1b
gene id: 7955:nav1b
uniprot id: A0A8M3ATQ4
uniprot id: A0A8M3ATS8
uniprot id: A0A8M3B0T7
uniprot id: A0A8M3B3R1
uniprot id: A0A8M6YZ14
uniprot id: A0A8M6YZ18
uniprot id: A0A8M6YZV2
uniprot id: A0A8M6Z1D6
uniprot id: A0A8M6Z1E1
uniprot id: A0A8M6Z711
uniprot id: A0A8M6Z7K4
uniprot id: A0A8M6Z7K9
uniprot id: A0A8M9QGG3
names: Similarity
messages: Belongs to the Nav/unc-53 family.

7955:tlx1
gene id: 7955:tlx1
uniprot id: B3DFP3
uniprot id: Q8JI13
names: Subcellular Location Annotation
messages: Nucleus

7955:megf8
gene id: 7955:megf8
uniprot id: F1QBZ9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:grm3
gene id: 7955:grm3
uniprot id: A3KPM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

7955:tmed1b
gene id: 7955:tmed1b
uniprot id: A0A8M6Z6L5
uniprot id: A1L273
uniprot id: F1QF76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

7955:LOC101886891
gene id: 7955:LOC101886891
uniprot id: A0A8M9PGA1
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

7955:si:ch211-252f13.5
gene id: 7955:si:ch211-252f13.5
uniprot id: A0A8M2BIG6
uniprot id: X1WBF6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:hspa14
gene id: 7955:hspa14
uniprot id: Q5RGE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC).
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state.
messages: cytosol

7955:rpl37
gene id: 7955:rpl37
uniprot id: Q6IQJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

7955:srpr
gene id: 7955:srpr
uniprot id: A0A8N7UW26
uniprot id: E7EZW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

7955:si:ch211-131k2.3
gene id: 7955:si:ch211-131k2.3
uniprot id: A0A8M1P869
uniprot id: F1QBW9
names: Similarity
messages: Belongs to the p23/wos2 family.

7955:rps15a
gene id: 7955:rps15a
uniprot id: Q6Q420
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.
messages: Morpholino-injected embryos have a thin yolk sac, bent tail, and show a marked decrease of erythrocyte production.
messages: Structural component of the ribosome (By similarity). Required for erythropoiesis during embryonic development (PubMed:27909223).

7955:zdhhc12a
gene id: 7955:zdhhc12a
uniprot id: B0S5D5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates.
messages: The DHHC domain is required for palmitoyltransferase activity.

7955:mafbb
gene id: 7955:mafbb
uniprot id: Q6P5N3
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

7955:LOC553386
gene id: 7955:LOC553386
uniprot id: A0A8M2BEQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:cers3b
gene id: 7955:cers3b
uniprot id: A0A8M2B5K0
uniprot id: A0A8M2B5Y1
uniprot id: A0A8M9PF77
uniprot id: A8WFT1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

7955:tmed1a
gene id: 7955:tmed1a
uniprot id: Q6DBT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

7955:pfklb
gene id: 7955:pfklb
uniprot id: A0A0R4ID68
uniprot id: A0A8M1P3T0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:ssbp1
gene id: 7955:ssbp1
uniprot id: B8A5I7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (By similarity). May be required to maintain the copy number of mitochondrial DNA (mtDNA) and play a crucial role during mtDNA replication (PubMed:31550240). Required for retinal ganglion cell differentiation and retinal integrity (PubMed:31298765).
messages: Mitochondrion
messages: Morpholino-induced knockdown results in reduction in optic nerve size and mitochondrial depletion (PubMed:31550240, PubMed:31298765). Strongly reduced expression of the developmental regulator genes isl1 and atoh7 in retinal ganglion cell (RGC) precursors (PubMed:31298765). Nonphotoreceptor cells, both in the ganglion cell layer and in the inner nuclear layer, display compromised neuronal specification, whereas cell numbers in both layers are unaltered (PubMed:31298765).
messages: mitochondrion nucleoid

7955:pdxka
gene id: 7955:pdxka
uniprot id: A0A8M1NHG6
uniprot id: A0A8M9QJU9
uniprot id: B0S7H1
names: Similarity
messages: Belongs to the pyridoxine kinase family.

7955:adnpb
gene id: 7955:adnpb
uniprot id: A0A8M3B615
uniprot id: E7F895
names: Subcellular Location Annotation
messages: Nucleus

7955:or126-4
gene id: 7955:or126-4
uniprot id: Q2PRF3
names: Subcellular Location Annotation
messages: Membrane

7955:si:dkey-23a13.5
gene id: 7955:si:dkey-23a13.5
uniprot id: Q05AK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

7955:slc24a3
gene id: 7955:slc24a3
uniprot id: A0A8N7T746
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

7955:im:7138535
gene id: 7955:im:7138535
uniprot id: A0A8M1P955
uniprot id: A0A8M3B005
uniprot id: F1QHG6
names: Similarity
messages: Belongs to the FAM98 family.

7955:wnt11r
gene id: 7955:wnt11r
uniprot id: Q9I9I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

7955:lpar6b
gene id: 7955:lpar6b
uniprot id: A0A8M2B891
uniprot id: X1WDA3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:or108-1
gene id: 7955:or108-1
uniprot id: Q2PRM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:gars
gene id: 7955:gars
uniprot id: A0A8M6YVR9
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

7955:med8
gene id: 7955:med8
uniprot id: Q6NYT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
messages: Component of the Mediator complex. May be part of a multisubunit E3 ubiquitin-protein ligase complex (By similarity).
messages: Nucleus

7955:bzw2
gene id: 7955:bzw2
uniprot id: A0A8M9PN66
uniprot id: Q1LUC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BZW family.
messages: Cytoplasm
messages: Translation initiation regulator which may repress non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function.

7955:LOC101884438
gene id: 7955:LOC101884438
uniprot id: A0A8M9QG68
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

7955:gbp
gene id: 7955:gbp
uniprot id: Q9YI01
names: Similarity
messages: Belongs to the GSK-3-binding protein family.

7955:unc119.1
gene id: 7955:unc119.1
uniprot id: A0A8M9Q9J8
uniprot id: Q90Z08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (By similarity).
messages: Belongs to the PDE6D/unc-119 family.
messages: Detected in embryo. Detected in larvae four days after fertilization, in retina and neural tissues (at protein level). Detected in embryos at the sphere stage, during gastrulation, somitogenesis and in swimming larvae, both within and outside of the developing nervous system. Detected in adults.
messages: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in localization of proteins to the primary cilium membrane.
messages: cilium

7955:ndufb3
gene id: 7955:ndufb3
uniprot id: Q6P119
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

7955:fgf11b
gene id: 7955:fgf11b
uniprot id: A0A8M1QQP9
uniprot id: E7F9J0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

7955:si:ch211-214c7.5
gene id: 7955:si:ch211-214c7.5
uniprot id: A3KNM4
names: Similarity
messages: Belongs to the UPF0575 family.

7955:u2af2a
gene id: 7955:u2af2a
uniprot id: A0A8M2B465
uniprot id: A0A8M9PJH8
uniprot id: E7F8Y4
uniprot id: Q4KMI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

7955:epdr1
gene id: 7955:epdr1
uniprot id: Q6DH25
names: Similarity
messages: Belongs to the ependymin family.

7955:tnfsf14
gene id: 7955:tnfsf14
uniprot id: E7FBC0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

7955:clcf1
gene id: 7955:clcf1
uniprot id: A0A8M9QPE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

7955:klf1
gene id: 7955:klf1
uniprot id: Q90XE6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed in cardiomyocytes.
messages: First expressed in the inner cell mass (ICM) of embryos at 18 hpf (hours post fertilization) and continues to be expressed in the developing embryo until at least 48 hpf (PubMed:18941117). Expressed in the developing hematopoietic system, at 24 hpf and circulating primitive erythrocytes at 48 hpf (PubMed:11535513, PubMed:18941117). Expressed in the pronephros, and in circulating definitive erythrocytes in the heart lumen and vessels of the tail at 8 dpf (days post fertilization) (PubMed:11535513).
messages: In adult heart myocardium upon injury (PubMed:33833125). Repressed in embryos by microRNA miR-144 (PubMed:18941117).
messages: Morpholino knockdown causes significant reduction in expression of embryonic alpha globin e1 hbae1.1 in 22 hpf (hours post fertilization) and 36 hpf embryos.
messages: Nucleus
messages: Transcription regulator (PubMed:18941117, PubMed:33833125). Plays a role in erythropoiesis, binding to promoters and activating transcription of embryonic alpha globin e1 hbae1.1 and microRNA mir-144, in erythroid progenitors; perhaps acting as part of a negative feedback loop with mir-144 (PubMed:33833125, PubMed:18941117). May coordinate repression of genes controlling myocardial differentiation and mitochondrial metabolism with positive modulation of cell proliferation genes (PubMed:33833125). Required for regeneration of the myocardium after injury, probably acting by stimulating renewal of preexisting cardiomyocytes in adult hearts (PubMed:33833125).
messages: cytosol

7955:ostc
gene id: 7955:ostc
uniprot id: Q7ZWJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
messages: Specific component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex.

7955:rpa1
gene id: 7955:rpa1
uniprot id: Q6NY74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus
messages: PML body

7955:sult2st3
gene id: 7955:sult2st3
uniprot id: A4FUP0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

7955:LOC101885154
gene id: 7955:LOC101885154
uniprot id: A0A8M2BEU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

7955:adrm1
gene id: 7955:adrm1
uniprot id: A0A8M1PDW7
uniprot id: A0A8M9PKV4
uniprot id: A8WGS1
uniprot id: E9QJJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

7955:p2rx2
gene id: 7955:p2rx2
uniprot id: Q7SZL9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

7955:slit3
gene id: 7955:slit3
uniprot id: A0A8M1PC10
uniprot id: A0A8M3ARY3
uniprot id: F1RCV3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:fzd8b
gene id: 7955:fzd8b
uniprot id: Q6NWX8
uniprot id: Q9PWK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

7955:drd2b
gene id: 7955:drd2b
uniprot id: Q7T1A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

7955:unm hu7910
gene id: 7955:unm_hu7910
uniprot id: A0A8M3B1J7
uniprot id: A0A8M9Q2V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.
messages: Membrane

7955:nccrp1
gene id: 7955:nccrp1
uniprot id: Q568V3
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in nonspecific cytotoxic cells (NCC).
messages: May promote cell proliferation.

7955:csnk1da
gene id: 7955:csnk1da
uniprot id: A0A286YAS3
uniprot id: A0A8M2BBB2
uniprot id: Q7T2E3
names: Activity Regulation
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated on serine and threonine residues.
messages: Belongs to the protein kinase superfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity).
messages: Cytoplasm
messages: Exhibits substrate-dependent heparin activation.
messages: Monomer (By similarity). Interacts with per1 and per2. Component of the circadian core oscillator (By similarity).
messages: Nucleus
messages: Ubiquitously expressed in embryos until eight hours after fertilization. Detected throughout the embryo, but particularly in the cephalic region, at 10 to 24 hours after fertilization. Detected in retina, tegmentum and myencephalon at 38 and 48 hours after fertilization.

7955:LOC565422
gene id: 7955:LOC565422
uniprot id: B3DK15
uniprot id: B3DK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:dnal4b
gene id: 7955:dnal4b
uniprot id: Q503Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

7955:dusp3a
gene id: 7955:dusp3a
uniprot id: E7EXY0
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

7955:unc5b
gene id: 7955:unc5b
uniprot id: A0A8M3AZ37
uniprot id: A9JR35
uniprot id: F1QXJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

7955:wls
gene id: 7955:wls
uniprot id: A0A8M1PIU9
uniprot id: F2Z4U3
uniprot id: Q7T357
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

7955:camta1b
gene id: 7955:camta1b
uniprot id: A0A8M6Z970
uniprot id: A0A8M9PVP1
uniprot id: A0A8M9Q7U3
uniprot id: A0A8M9QDS7
uniprot id: A0A8M9QI84
uniprot id: A0A8M9QM43
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

7955:gpbp1l1
gene id: 7955:gpbp1l1
uniprot id: A0A0R4IH70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

7955:gcdhb
gene id: 7955:gcdhb
uniprot id: Q5XJA7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

7955:urb2
gene id: 7955:urb2
uniprot id: B0V0U5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Essential for hematopietic stem cell development through the regulation of p53/TP53 pathway.
messages: Expression in caudal hematopoietic tissue initiates during hematopietic stem cell expansion stages, and the expression level from 72 hours post-fertilization (hpf) to 96 hpf is much higher than that at 48 hpf.
messages: Mutants show a notable decrease in the population of hematopietic stem cells in caudal hematopoietic tissue and early T-cells in thymus (PubMed:29470984). Compromised cell proliferation and excessive apoptosis are observed in the caudal hematopoietic tissue (PubMed:29470984).
messages: nucleolus

7955:htr2b
gene id: 7955:htr2b
uniprot id: Q0GH74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

7955:cdc42bpb
gene id: 7955:cdc42bpb
uniprot id: A0A8M3AT38
uniprot id: A0A8M9P2Q2
uniprot id: A0A8M9PBW0
uniprot id: B3DJP1
uniprot id: Q5TZ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: lamellipodium

7955:fam171b
gene id: 7955:fam171b
uniprot id: A0A8N7T5V6
uniprot id: I3IRX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

7955:nt5e
gene id: 7955:nt5e
uniprot id: Q7SXU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

7955:slc16a12b
gene id: 7955:slc16a12b
uniprot id: A0A8M1NTF7
uniprot id: F1Q846
names: Subcellular Location Annotation
messages: Membrane

7955:LOC101882239
gene id: 7955:LOC101882239
uniprot id: A0A8M6Z152
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

7955:pimr88
gene id: 7955:pimr88
uniprot id: A0A8M9PNT5
names: Similarity
messages: Belongs to the protein kinase superfamily.

7955:polg
gene id: 7955:polg
uniprot id: A0A8M1QHI8
uniprot id: F8W5R6
names: Function
names: Subcellular Location Annotation
messages: Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.
messages: mitochondrion nucleoid

7955:tpm2
gene id: 7955:tpm2
uniprot id: A0A0R4IAL5
uniprot id: A0A0R4IM99
uniprot id: A0A8M2B1K3
uniprot id: A0A8M2B1Q6
uniprot id: A0A8M2B1Q8
uniprot id: A0A8M2B1Z0
uniprot id: A0A8M2B255
uniprot id: A0A8M2B2D1
uniprot id: A0A8M6Z8R9
uniprot id: Q6IQD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

7955:prtga
gene id: 7955:prtga
uniprot id: Q2EY14
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Expression begins at 80% epiboly and is extinguished by 48 hours post-fertilization.
messages: Expression begins in the posterior region of the embryo and this posterior restriction persists at the 4 s stage. At early somite stages, expressed along the neural tube with lower levels in the lateral and paraxial mesoderm. Expression decreases caudally and rostrally becomes restricted to the ventral part of the brain. Widespread in the spinal cord at 30 hours post-fertilization (hpf) and is also expressed in the lens from this time. At 40 hpf, expression is restricted to the lens.
messages: May play a role in anteroposterior axis elongation.
messages: Membrane

7955:itgav
gene id: 7955:itgav
uniprot id: Q3LTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

7955:zfhx3
gene id: 7955:zfhx3
uniprot id: A0A8M9PQC4
uniprot id: A0A8M9QI68
names: Subcellular Location Annotation
messages: Nucleus

7955:sepp1b
gene id: 7955:sepp1b
uniprot id: A0A8M1PE85
names: Subcellular Location Annotation
messages: Secreted

7955:psmd9
gene id: 7955:psmd9
uniprot id: A0A8M1N0I7
uniprot id: A0A8M2BGF5
uniprot id: F1R7L1
uniprot id: Q6DH53
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

7955:ush2a
gene id: 7955:ush2a
uniprot id: A0A8M3ARH7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:tex10
gene id: 7955:tex10
uniprot id: Q803M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of some MLL1/MLL complex. Component of the PELP1 complex, composed of at least pelp1, tex10 and wdr18. The complex interacts with pre-60S ribosome particles.
messages: Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

7955:si:dkey-174n20.1
gene id: 7955:si:dkey-174n20.1
uniprot id: A0A8M2BCK6
uniprot id: A3KNN9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

7955:mrps18a
gene id: 7955:mrps18a
uniprot id: A0A8M1N7H6
uniprot id: Q5TYW5
names: Subcellular Location Annotation
messages: Mitochondrion

7955:sike1
gene id: 7955:sike1
uniprot id: A0A0R4ISE8
uniprot id: A0A8M3AN84
names: Similarity
messages: Belongs to the SIKE family.

7955:yy1b
gene id: 7955:yy1b
uniprot id: A0A8M2BHN0
uniprot id: Q7T304
names: Similarity
messages: Belongs to the YY transcription factor family.

7955:cyp4v7
gene id: 7955:cyp4v7
uniprot id: A0JMN1
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:ttc3
gene id: 7955:ttc3
uniprot id: A0A8M2BJT8
uniprot id: A0A8M3B5Y4
uniprot id: A0A8M3BCR2
uniprot id: E7EYR3
names: Subcellular Location Annotation
messages: Cytoplasm

7955:gng13b
gene id: 7955:gng13b
uniprot id: Q6DH00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:rps6
gene id: 7955:rps6
uniprot id: Q6DHL6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

7955:casp6l2
gene id: 7955:casp6l2
uniprot id: A0A8M6Z4Y1
uniprot id: Q29R92
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

7955:pcdh2g9
gene id: 7955:pcdh2g9
uniprot id: I6LD76
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

7955:snta1
gene id: 7955:snta1
uniprot id: A0A8M1RLW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

7955:lin28a
gene id: 7955:lin28a
uniprot id: A0A2R8Q8W5
uniprot id: A0A8M2B642
uniprot id: I3IS11
uniprot id: Q803L0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-28 family.
messages: Cytoplasm
messages: Monomer.
messages: P-body
messages: RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Suppressor of microRNA (miRNA) biogenesis, including that of let-7. Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity).
messages: Rough endoplasmic reticulum
messages: Stress granule
messages: The CCHC zinc fingers interact with the GGAG motif at the 3' end of let-7 miRNAs precursors, more generally they bind the 5'-NGNNG-3' consensus motif with micromolar affinity. The CSD domain recognizes the loop at the 5' end. The flexible linker allows accommodating variable sequences and lengths among let-7 family members (By similarity).
messages: nucleolus

7955:shtn1
gene id: 7955:shtn1
uniprot id: A0A8M9PE57
uniprot id: Q6P0R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth.
messages: Perikaryon
messages: axon
messages: cytoskeleton
messages: filopodium
messages: growth cone
messages: lamellipodium

7955:gpr137c
gene id: 7955:gpr137c
uniprot id: A0A8M2BHJ8
uniprot id: Q5U3S6
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

7955:ano10a
gene id: 7955:ano10a
uniprot id: Q4V8U5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1 (By similarity).
messages: Membrane
messages: The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

7955:nav1a
gene id: 7955:nav1a
uniprot id: A0A2R8QLY4
uniprot id: A0A8M1RJJ7
uniprot id: A0A8M3AMM5
uniprot id: A0A8M6YVD2
uniprot id: E7FBA8
names: Similarity
messages: Belongs to the Nav/unc-53 family.

7955:LOC793010
gene id: 7955:LOC793010
uniprot id: A0A8M9PSA6
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:mylpfb
gene id: 7955:mylpfb
uniprot id: Q66I73
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains.

7955:mbtps1
gene id: 7955:mbtps1
uniprot id: Q1LWH3
names: Similarity
messages: Belongs to the peptidase S8 family.

7955:mocs1
gene id: 7955:mocs1
uniprot id: A0A8M3AJ79
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

7955:LOC567521
gene id: 7955:LOC567521
uniprot id: A0A8N7T815
names: Subcellular Location Annotation
messages: Membrane

7955:gdf6b
gene id: 7955:gdf6b
uniprot id: A8E7N9
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: By shh.
messages: Expression is correlated temporally and spatially with somitogenesis. At late gastrula stage, expressed in the posterior presumptive neural plate. During somitogenesis, expression becomes restricted along the dorsoventral axis of the trunk neural tube in an anterior-to-posterior progression so that upon completion of somitogenesis, expression is seen exclusively in the ventral spinal cord with the exclusion of the floor plate and adjacent neural cells.
messages: Homodimer; disulfide-linked.
messages: Secreted

7955:gabra6a
gene id: 7955:gabra6a
uniprot id: A0A8M2BKE0
uniprot id: F1QKC4
uniprot id: Q6PC15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

7955:egr3
gene id: 7955:egr3
uniprot id: Q6DG27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

7955:ogt.1
gene id: 7955:ogt.1
uniprot id: A0A8M3B8G4
uniprot id: Q5GA10
uniprot id: Q5GA11
uniprot id: Q5GA12
uniprot id: Q5GA13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cell projection
messages: Mitochondrion membrane

7955:g6pc3
gene id: 7955:g6pc3
uniprot id: A1A5Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane
messages: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).

7955:xylb
gene id: 7955:xylb
uniprot id: Q7T342
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

7955:pbrm1l
gene id: 7955:pbrm1l
uniprot id: A0A8M1N183
uniprot id: A0A8M2BG23
uniprot id: E7EZ71
names: Subcellular Location Annotation
messages: Nucleus

7955:usb1
gene id: 7955:usb1
uniprot id: A0A8M3APM6
uniprot id: A0A8M3AZL1
uniprot id: Q6DEF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1.
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.

7955:mogs
gene id: 7955:mogs
uniprot id: A1L1S8
uniprot id: B8A4C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

7955:dlx4a
gene id: 7955:dlx4a
uniprot id: Q98879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

7955:lysmd4
gene id: 7955:lysmd4
uniprot id: Q6P606
names: Subcellular Location Annotation
messages: Membrane

7955:cyp2ad6
gene id: 7955:cyp2ad6
uniprot id: A0A8M9PHK9
uniprot id: B3DHN0
uniprot id: Q5TZ81
names: Similarity
messages: Belongs to the cytochrome P450 family.

7955:nnt2
gene id: 7955:nnt2
uniprot id: A0A8M6Z2N7
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

7955:kbtbd8
gene id: 7955:kbtbd8
uniprot id: B7ZVA9
uniprot id: Q08CL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KBTBD8 family.
messages: Component of the BCR(KBTBD8) E3 ubiquitin ligase complex.
messages: Golgi apparatus
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (By similarity). The BCR(KBTBD8) complex acts by mediating monoubiquitination of target proteins (By similarity).
messages: spindle

7955:slc25a25b
gene id: 7955:slc25a25b
uniprot id: A0A8M3AZQ0
uniprot id: A0A8M3B2K2
uniprot id: A2CEQ0
uniprot id: F1QR29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Calcium-dependent mitochondrial solute carrier.
messages: Membrane
messages: Mitochondrion inner membrane

7955:prokr1a
gene id: 7955:prokr1a
uniprot id: D3TZW3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:grm1a
gene id: 7955:grm1a
uniprot id: A0A2R9YJL7
uniprot id: A0A8M1RMJ3
uniprot id: A0A8M3ATC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

7955:nudt19
gene id: 7955:nudt19
uniprot id: A0A8M2BGC3
uniprot id: B3DHE6
uniprot id: F6NQZ7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

7955:zp2.5
gene id: 7955:zp2.5
uniprot id: A0A8M1P7K6
uniprot id: F1QUS3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:oprl1
gene id: 7955:oprl1
uniprot id: A0A0R4IZH2
uniprot id: A0A8M1P286
uniprot id: A0A8M6Z4E3
uniprot id: Q7T3Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

7955:ints2
gene id: 7955:ints2
uniprot id: A0A8M1N5X8
uniprot id: E9QC62
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

7955:ugt1b2
gene id: 7955:ugt1b2
uniprot id: D3XD61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

7955:zgc:92606
gene id: 7955:zgc:92606
uniprot id: Q6DH82
names: Similarity
messages: Belongs to the ATG8 family.

7955:atp2b1b
gene id: 7955:atp2b1b
uniprot id: A0A8M3APN2
uniprot id: A0A8M9PUY9
uniprot id: B2CZB7
uniprot id: F1QBG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:gorasp1b
gene id: 7955:gorasp1b
uniprot id: A0A0H2UJY9
uniprot id: A0A8M1P8H6
uniprot id: A0A8M1RRZ2
names: Similarity
messages: Belongs to the GORASP family.

7955:rnf7
gene id: 7955:rnf7
uniprot id: Q5EB19
names: Similarity
messages: Belongs to the RING-box family.

7955:eif2s1a
gene id: 7955:eif2s1a
uniprot id: Q7ZWD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

7955:slc6a1b
gene id: 7955:slc6a1b
uniprot id: Q5U3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

7955:dtx4
gene id: 7955:dtx4
uniprot id: A0A8M1RDA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

7955:si:dkey-178o16.4
gene id: 7955:si:dkey-178o16.4
uniprot id: E7F1C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

7955:dcbld2
gene id: 7955:dcbld2
uniprot id: A0A8N7UYK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:snap47
gene id: 7955:snap47
uniprot id: A0A8M9QH05
uniprot id: Q0P4A7
names: Function
names: Similarity
messages: Belongs to the SVAP1 family.
messages: May play a role in intracellular membrane fusion.

7955:ubr4
gene id: 7955:ubr4
uniprot id: A0A8M3AVE1
uniprot id: A0A8M6YVB9
uniprot id: A0A8M6YVC3
uniprot id: A0A8M6YVC7
uniprot id: A0A8M6YVZ4
uniprot id: A0A8M6YXU8
uniprot id: A0A8M6Z3V2
uniprot id: A0A8M6Z3V7
uniprot id: A0A8M6Z4I7
uniprot id: A0A8M9PDY5
uniprot id: A0A8M9PQN9
uniprot id: A0A8M9PWV4
uniprot id: A0A8M9PWV7
uniprot id: A0A8M9Q7V9
names: Similarity
messages: Belongs to the UBR4 family.

7955:txndc5
gene id: 7955:txndc5
uniprot id: A0A8M2B9N7
uniprot id: F1R184
uniprot id: Q6PFL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

7955:tom1l2
gene id: 7955:tom1l2
uniprot id: A0A8M1P4G2
uniprot id: A0A8M1PAR2
uniprot id: A0A8M2B2H9
uniprot id: A0A8M2BIY6
uniprot id: A0A8M3AR96
uniprot id: A0A8M3AYD1
uniprot id: A0A8M3AYE7
uniprot id: A0A8M3AYE8
uniprot id: A0A8M3B1D1
uniprot id: A0A8M3BE68
uniprot id: E7F811
names: Similarity
messages: Belongs to the TOM1 family.

7955:inab
gene id: 7955:inab
uniprot id: A0A8N7UZF7
uniprot id: F1Q8F1
names: Similarity
messages: Belongs to the intermediate filament family.

7955:sec23b
gene id: 7955:sec23b
uniprot id: A0A8M6Z6P7
uniprot id: Q7ZVV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

7955:gab1
gene id: 7955:gab1
uniprot id: A0A8M1P8X5
uniprot id: A0A8M3AJA8
uniprot id: A0A8M6YUV9
uniprot id: A0A8M6YVD8
uniprot id: A0A8M9P5A1
uniprot id: A0A8M9PTD5
uniprot id: F1Q7S5
uniprot id: F6NTT0
names: Similarity
messages: Belongs to the GAB family.

7955:akt3b
gene id: 7955:akt3b
uniprot id: E7EXT6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

7955:hmx4
gene id: 7955:hmx4
uniprot id: A0A8M1N9F2
uniprot id: B7ZD71
uniprot id: Q0P3T9
names: Subcellular Location Annotation
messages: Nucleus

7955:uqcc1
gene id: 7955:uqcc1
uniprot id: Q08CE4
names: Similarity
messages: Belongs to the CBP3 family.

7955:nrxn1b
gene id: 7955:nrxn1b
uniprot id: A0A8M1P5W2
uniprot id: A0A8M3AYQ8
uniprot id: A0A8M3AYS8
uniprot id: A0A8M3B4Y5
uniprot id: A0A8M3B7R4
uniprot id: A0A8M9PXV2
uniprot id: A0A8N7UYH3
uniprot id: F1R7M4
uniprot id: F8W597
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

7955:slc5a2
gene id: 7955:slc5a2
uniprot id: Q6NWD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

7955:gng10
gene id: 7955:gng10
uniprot id: A0A0G2L6W9
uniprot id: A0A8M1P1V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

7955:mal
gene id: 7955:mal
uniprot id: Q567J3
names: Subcellular Location Annotation
messages: Membrane

7955:plppr3a
gene id: 7955:plppr3a
uniprot id: A0A8M1NT41
uniprot id: B0V0Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

7955:si:ch73-368j24.12
gene id: 7955:si:ch73-368j24.12
uniprot id: A0A140LH63
uniprot id: A0A8M1RSM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

7955:nap1l4a
gene id: 7955:nap1l4a
uniprot id: A0A2R8Q4J7
uniprot id: A0A8M2BIE8
uniprot id: A4QP71
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

7955:chmp7
gene id: 7955:chmp7
uniprot id: Q6PBQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway.
messages: Nucleus envelope

7955:gfra1b
gene id: 7955:gfra1b
uniprot id: Q98TT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane

7955:LOC100149482
gene id: 7955:LOC100149482
uniprot id: A0A8M3AT83
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

7955:hpse2
gene id: 7955:hpse2
uniprot id: A0A8M3AZF6
uniprot id: A0A8M3B5H5
uniprot id: A0A8M3BEU7
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

7955:comtb
gene id: 7955:comtb
uniprot id: A4IG53
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.
messages: Secreted
messages: Strongly expressed in eye, diencephalon, spinal cord, hindbrain, liver, kidney and telencephalon. Also detected at very low levels in muscle, spleen, anterior gut and heart. In eye, expressed strongly in retina. In brain, expressed in the central part of the telencephalon, the periventricular gray zone of the optic tectum, the periglomerular nucleus, the olfactory bulb, and the region adjacent to the diencephalic ventricle in the hypothalamus. Expressed in gill, with strongest expression in gill filaments nearest the gill arch, and in esophageal epithelium.

7955:si:dkey-27p18.2
gene id: 7955:si:dkey-27p18.2
uniprot id: A0A8M1PSM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

7955:dhdds
gene id: 7955:dhdds
uniprot id: Q6NXA2
names: Similarity
messages: Belongs to the UPP synthase family.

7955:igfbp3
gene id: 7955:igfbp3
uniprot id: Q66I28
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

7955:si:ch73-368j24.3
gene id: 7955:si:ch73-368j24.3
uniprot id: A0A8M3B0X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus

7955:hdac5
gene id: 7955:hdac5
uniprot id: A0A8M3AQH0
uniprot id: A0A8M3AQU0
uniprot id: A0A8M3B885
uniprot id: A0A8N7T5F3
uniprot id: E7FH14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

7955:cts12
gene id: 7955:cts12
uniprot id: A0A8M9PDG6
uniprot id: F1QCP8
names: Similarity
messages: Belongs to the peptidase C1 family.

7955:fas
gene id: 7955:fas
uniprot id: A0A8M9P0K2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

7955:ptgis
gene id: 7955:ptgis
uniprot id: F1RE08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (By similarity).
messages: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
messages: Endoplasmic reticulum membrane

7955:LOC566064
gene id: 7955:LOC566064
uniprot id: A0A8M9Q2Q3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:acanb
gene id: 7955:acanb
uniprot id: A0A8M9P6I2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:polr3gla
gene id: 7955:polr3gla
uniprot id: A0A0R4INA2
uniprot id: A0A8M1N2F0
uniprot id: A0A8M1P334
uniprot id: Q66IE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

7955:cldng
gene id: 7955:cldng
uniprot id: B2GPD3
uniprot id: Q9YH90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Component of tight junction (TJ) strands.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

7955:fam19a5a
gene id: 7955:fam19a5a
uniprot id: A0A2R8QIB8
uniprot id: A0A8M1NI93
uniprot id: A0A8M2BFV2
uniprot id: A0A8M2BFV3
uniprot id: A0A8M2BFW6
uniprot id: A0A8M2BGH3
uniprot id: A2BIC8
uniprot id: E9QB79
uniprot id: H0WEJ8
names: Similarity
messages: Belongs to the TAFA family.

7955:neu3.1
gene id: 7955:neu3.1
uniprot id: A0A8M2B8F8
uniprot id: A0PJS4
uniprot id: I3ITP7
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

7955:kcnv2a
gene id: 7955:kcnv2a
uniprot id: A0A8N7T6K3
uniprot id: F1Q6N3
names: Subcellular Location Annotation
messages: Membrane

7955:si:ch73-97h19.2
gene id: 7955:si:ch73-97h19.2
uniprot id: A0A0R4IBA4
uniprot id: A0A8N7TFT2
names: Subunit
messages: Homodimer.

7955:taar12b
gene id: 7955:taar12b
uniprot id: Q5QNQ3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

7955:si:dkey-145c18.2
gene id: 7955:si:dkey-145c18.2
uniprot id: A0A8M3AKJ6
names: Similarity
messages: Belongs to the NAPRTase family.

7955:vamp8
gene id: 7955:vamp8
uniprot id: Q7ZUC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

7955:cacnb4a
gene id: 7955:cacnb4a
uniprot id: A8WHZ5
uniprot id: B0F0C9
uniprot id: B0F0D0
uniprot id: B7ZVI1
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

7955:gk5
gene id: 7955:gk5
uniprot id: A0A8N7UYF7
uniprot id: F1QS50
names: Similarity
messages: Belongs to the FGGY kinase family.

7955:dytn
gene id: 7955:dytn
uniprot id: A2CI97
names: Subcellular Location Annotation
messages: Cell membrane

7955:LOC100147904
gene id: 7955:LOC100147904
uniprot id: A0A8M1QQZ4
uniprot id: A0A8M9QCN3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

7955:LOC402866
gene id: 7955:LOC402866
uniprot id: A0A8M6Z4H3
uniprot id: A0A8M9P5P4
uniprot id: A0A8M9PFQ6
names: Subcellular Location Annotation
messages: Nucleus

7955:cacna2d4a
gene id: 7955:cacna2d4a
uniprot id: A0A8M6Z656
uniprot id: A0A8M9QBV8
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

7955:mycla
gene id: 7955:mycla
uniprot id: Q9PSI9
names: Developmental Stage
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with max (By similarity).
messages: Most abundant during early rapid cleavage, blastulation, and gastrulation. Reduced levels from time of establishment of the body plan (around 12 hours) and thereafter.
messages: Nucleus
messages: Uterus.

7955:zgc:171452
gene id: 7955:zgc:171452
uniprot id: A7YY96
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

7955:mis12
gene id: 7955:mis12
uniprot id: Q7T344
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

7955:riok1
gene id: 7955:riok1
uniprot id: Q7ZV65
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

7955:tor4aa
gene id: 7955:tor4aa
uniprot id: A0A0H2UKC7
uniprot id: A0A8M1N582
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Membrane

7955:stat4
gene id: 7955:stat4
uniprot id: A0A2R8S045
uniprot id: A0A8M2BFB6
uniprot id: A0A8M2BFD4
uniprot id: A0A8M9QAM0
uniprot id: B0S790
uniprot id: Q8AW20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

7955:itgb1b.1
gene id: 7955:itgb1b.1
uniprot id: B3DIV2
uniprot id: Q3YA99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Melanosome
messages: Membrane
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

7955:insm1a
gene id: 7955:insm1a
uniprot id: Q6P0F9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSM1 family.
messages: Expressed both maternally and zygotically. Expressed at 10 hours post-fertilization (hpf), reach peak levels at 48 hpf and is not detectable in adult tissues. Expressed during neurogenesis between 9 and 72 hpf and in ventral endoderm region where pancreatic progenitors originate.
messages: May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity).
messages: Nucleus

7955:pax6b
gene id: 7955:pax6b
uniprot id: A0A0R4IQL7
uniprot id: A0A8M2BG41
uniprot id: A0A8M2BGP0
uniprot id: A0A8M3B3W1
uniprot id: A0A8M9PP46
uniprot id: A0A8M9Q1T3
uniprot id: Q9YHZ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

7955:sh3rf1
gene id: 7955:sh3rf1
uniprot id: A0A8M1N9B8
uniprot id: A5D8S5
uniprot id: B3DIT8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autoubiquitinated. Ubiquitinated by SH3RF2, leading to proteasome-mediated degradation.
messages: Belongs to the SH3RF family.
messages: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway.
messages: The RING finger domain is required for ubiquitin ligase activity and autoubiquitination.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

7955:tlr4bb
gene id: 7955:tlr4bb
uniprot id: A0A8M1PFR8
uniprot id: B8A691
uniprot id: Q6TS41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

7955:si:dkey-72l14.3
gene id: 7955:si:dkey-72l14.3
uniprot id: A0A8M1N9Q8
uniprot id: Q1LVE3
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

7955:scn4aa
gene id: 7955:scn4aa
uniprot id: A0A0R4IJX4
uniprot id: A0A8M6Z1C6
uniprot id: Q2XVR3
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.
messages: Cell membrane
messages: Channel activity is regulated by ancillary beta subunits. Interaction with a beta subunit is required for rapid channel inactivation and rapid recovery after inactivation, and prevents decrease of channel activity in response to repetitive, high-frequency depolarizations.
messages: Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits.
messages: Expressed in skeletal muscle, brain, spinal cord, and eye.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane
messages: Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles.
messages: The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

7955:aifm1
gene id: 7955:aifm1
uniprot id: A0A8M2BCB6
uniprot id: A0A8M2BCF4
uniprot id: A0A8M3AS24
uniprot id: Q5XFY2
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

7955:ggnbp2
gene id: 7955:ggnbp2
uniprot id: A0A8M1NCD3
uniprot id: A0A8M2BC71
uniprot id: F6PDK1
uniprot id: Q1JQ05
names: Function
messages: May be involved in spermatogenesis.

7955:chadla
gene id: 7955:chadla
uniprot id: A0A8M6YXN0
uniprot id: E7EXH9
names: Similarity
messages: Belongs to the Toll-like receptor family.

7955:kcnj13
gene id: 7955:kcnj13
uniprot id: Q0KIZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

7955:tpp1
gene id: 7955:tpp1
uniprot id: A0A8M2B594
uniprot id: F8W2M8
names: Caution
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Activated by autocatalytic proteolytical processing.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Expressed in retina at 48 hours post-fertilization (at protein level). Detected in all retinal cell layers but has particularly strong expression in the outer nuclear layer and ganglion cell layer (at protein level).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:23587805). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity).
messages: Lysosome
messages: Morpholino knockdown of the protein in embryos results in developmental defects from 48 hours post-fertilization onwards, including reduced eye and head size, a curved body, small jaw, and loss of the swim bladder.

7955:mos
gene id: 7955:mos
uniprot id: Q90YD0
names: Similarity
messages: Belongs to the protein kinase superfamily.