795359:TOPB45 RS00485
gene id: 795359:TOPB45_RS00485
uniprot id: F8C254
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

795359:TOPB45 RS05485
gene id: 795359:TOPB45_RS05485
uniprot id: F8C610
names: Similarity
messages: Belongs to the type IA topoisomerase family.

795359:TOPB45 RS05995
gene id: 795359:TOPB45_RS05995
uniprot id: F8C694
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

795359:TOPB45 RS07575
gene id: 795359:TOPB45_RS07575
uniprot id: F8C355
names: Similarity
messages: Belongs to the peptidase S66 family.

795359:TOPB45 RS07895
gene id: 795359:TOPB45_RS07895
uniprot id: F8C530
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

795359:TOPB45 RS05865
gene id: 795359:TOPB45_RS05865
uniprot id: F8C4S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS06725
gene id: 795359:TOPB45_RS06725
uniprot id: F8C4T3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

795359:TOPB45 RS04500
gene id: 795359:TOPB45_RS04500
uniprot id: F8C5J1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

795359:TOPB45 RS08545
gene id: 795359:TOPB45_RS08545
uniprot id: F8C509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

795359:TOPB45 RS05085
gene id: 795359:TOPB45_RS05085
uniprot id: F8C4I7
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

795359:TOPB45 RS04550
gene id: 795359:TOPB45_RS04550
uniprot id: F8C5K1
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

795359:TOPB45 RS07495
gene id: 795359:TOPB45_RS07495
uniprot id: F8C342
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS00640
gene id: 795359:TOPB45_RS00640
uniprot id: F8C2F2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS05840
gene id: 795359:TOPB45_RS05840
uniprot id: F8C668
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

795359:TOPB45 RS00090
gene id: 795359:TOPB45_RS00090
uniprot id: F8C1R5
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS08070
gene id: 795359:TOPB45_RS08070
uniprot id: F8C3T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

795359:TOPB45 RS05155
gene id: 795359:TOPB45_RS05155
uniprot id: F8C4I8
names: Similarity
messages: Belongs to the GARS family.

795359:TOPB45 RS00850
gene id: 795359:TOPB45_RS00850
uniprot id: F8C2J1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

795359:TOPB45 RS07535
gene id: 795359:TOPB45_RS07535
uniprot id: F8C350
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS07185
gene id: 795359:TOPB45_RS07185
uniprot id: F8C2Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

795359:TOPB45 RS07775
gene id: 795359:TOPB45_RS07775
uniprot id: F8C522
names: Similarity
messages: Belongs to the GSP E family.

795359:TOPB45 RS03890
gene id: 795359:TOPB45_RS03890
uniprot id: F8C4G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

795359:TOPB45 RS02730
gene id: 795359:TOPB45_RS02730
uniprot id: F8C4C3
names: Similarity
messages: Belongs to the Fur family.

795359:TOPB45 RS06205
gene id: 795359:TOPB45_RS06205
uniprot id: F8C4S4
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS00990
gene id: 795359:TOPB45_RS00990
uniprot id: F8C2T0
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

795359:TOPB45 RS04895
gene id: 795359:TOPB45_RS04895
uniprot id: F8C5R2
names: Similarity
messages: Belongs to the TrpF family.

795359:TOPB45 RS02245
gene id: 795359:TOPB45_RS02245
uniprot id: F8C3Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

795359:TOPB45 RS05175
gene id: 795359:TOPB45_RS05175
uniprot id: F8C5V5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

795359:TOPB45 RS00450
gene id: 795359:TOPB45_RS00450
uniprot id: F8C249
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

795359:TOPB45 RS03950
gene id: 795359:TOPB45_RS03950
uniprot id: F8C594
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

795359:TOPB45 RS03665
gene id: 795359:TOPB45_RS03665
uniprot id: F8C519
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

795359:TOPB45 RS05325
gene id: 795359:TOPB45_RS05325
uniprot id: F8C5Y5
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

795359:TOPB45 RS01490
gene id: 795359:TOPB45_RS01490
uniprot id: F8C388
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

795359:TOPB45 RS00760
gene id: 795359:TOPB45_RS00760
uniprot id: F8C2H7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

795359:TOPB45 RS06280
gene id: 795359:TOPB45_RS06280
uniprot id: F8C1X4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

795359:TOPB45 RS05015
gene id: 795359:TOPB45_RS05015
uniprot id: F8C5T1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

795359:TOPB45 RS02010
gene id: 795359:TOPB45_RS02010
uniprot id: F8C475
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

795359:TOPB45 RS02410
gene id: 795359:TOPB45_RS02410
uniprot id: F8C426
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

795359:TOPB45 RS02560
gene id: 795359:TOPB45_RS02560
uniprot id: F8C493
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

795359:TOPB45 RS08555
gene id: 795359:TOPB45_RS08555
uniprot id: F8C5C5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

795359:TOPB45 RS00570
gene id: 795359:TOPB45_RS00570
uniprot id: F8C2D8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

795359:TOPB45 RS05560
gene id: 795359:TOPB45_RS05560
uniprot id: F8C4R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

795359:TOPB45 RS04780
gene id: 795359:TOPB45_RS04780
uniprot id: F8C5P0
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

795359:TOPB45 RS01955
gene id: 795359:TOPB45_RS01955
uniprot id: F8C3N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

795359:TOPB45 RS04325
gene id: 795359:TOPB45_RS04325
uniprot id: F8C5G0
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

795359:TOPB45 RS02000
gene id: 795359:TOPB45_RS02000
uniprot id: F8C474
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

795359:TOPB45 RS07280
gene id: 795359:TOPB45_RS07280
uniprot id: F8C303
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

795359:TOPB45 RS07590
gene id: 795359:TOPB45_RS07590
uniprot id: F8C3C5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

795359:TOPB45 RS04040
gene id: 795359:TOPB45_RS04040
uniprot id: F8C4H0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

795359:TOPB45 RS00320
gene id: 795359:TOPB45_RS00320
uniprot id: F8C226
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

795359:TOPB45 RS08030
gene id: 795359:TOPB45_RS08030
uniprot id: F8C3S3
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS02470
gene id: 795359:TOPB45_RS02470
uniprot id: F8C480
names: Similarity
messages: Belongs to the UPF0758 family.

795359:TOPB45 RS05915
gene id: 795359:TOPB45_RS05915
uniprot id: F8C680
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS05125
gene id: 795359:TOPB45_RS05125
uniprot id: F8C5U7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

795359:TOPB45 RS04335
gene id: 795359:TOPB45_RS04335
uniprot id: F8C5G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

795359:TOPB45 RS00065
gene id: 795359:TOPB45_RS00065
uniprot id: F8C1R0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS04570
gene id: 795359:TOPB45_RS04570
uniprot id: F8C5K5
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

795359:TOPB45 RS05130
gene id: 795359:TOPB45_RS05130
uniprot id: F8C5U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

795359:TOPB45 RS03085
gene id: 795359:TOPB45_RS03085
uniprot id: F8C4M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

795359:TOPB45 RS07505
gene id: 795359:TOPB45_RS07505
uniprot id: F8C344
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

795359:TOPB45 RS00325
gene id: 795359:TOPB45_RS00325
uniprot id: F8C227
names: Subcellular Location Annotation
messages: Cytoplasm

795359:TOPB45 RS00490
gene id: 795359:TOPB45_RS00490
uniprot id: F8C255
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

795359:TOPB45 RS05850
gene id: 795359:TOPB45_RS05850
uniprot id: F8C4S0
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS07530
gene id: 795359:TOPB45_RS07530
uniprot id: F8C349
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

795359:TOPB45 RS03620
gene id: 795359:TOPB45_RS03620
uniprot id: F8C510
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

795359:TOPB45 RS00460
gene id: 795359:TOPB45_RS00460
uniprot id: F8C250
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

795359:TOPB45 RS01750
gene id: 795359:TOPB45_RS01750
uniprot id: F8C3J5
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS00995
gene id: 795359:TOPB45_RS00995
uniprot id: F8C2T1
names: Similarity
messages: Belongs to the peptidase C40 family.

795359:TOPB45 RS03160
gene id: 795359:TOPB45_RS03160
uniprot id: F8C4N9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

795359:TOPB45 RS00680
gene id: 795359:TOPB45_RS00680
uniprot id: F8C2G0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

795359:TOPB45 RS00070
gene id: 795359:TOPB45_RS00070
uniprot id: F8C1R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

795359:TOPB45 RS06550
gene id: 795359:TOPB45_RS06550
uniprot id: F8C291
names: Similarity
messages: Belongs to the YggT family.

795359:TOPB45 RS08525
gene id: 795359:TOPB45_RS08525
uniprot id: F8C492
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

795359:TOPB45 RS03595
gene id: 795359:TOPB45_RS03595
uniprot id: F8C507
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

795359:TOPB45 RS05145
gene id: 795359:TOPB45_RS05145
uniprot id: F8C5V1
names: Similarity
messages: Belongs to the DprA/Smf family.

795359:TOPB45 RS00820
gene id: 795359:TOPB45_RS00820
uniprot id: F8C2I5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

795359:TOPB45 RS00255
gene id: 795359:TOPB45_RS00255
uniprot id: F8C215
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS03060
gene id: 795359:TOPB45_RS03060
uniprot id: F8C4M1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS01380
gene id: 795359:TOPB45_RS01380
uniprot id: F8C366
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

795359:TOPB45 RS01620
gene id: 795359:TOPB45_RS01620
uniprot id: F8C473
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

795359:TOPB45 RS00240
gene id: 795359:TOPB45_RS00240
uniprot id: F8C212
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

795359:TOPB45 RS04650
gene id: 795359:TOPB45_RS04650
uniprot id: F8C5M1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

795359:TOPB45 RS02835
gene id: 795359:TOPB45_RS02835
uniprot id: F8C4E1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

795359:TOPB45 RS06915
gene id: 795359:TOPB45_RS06915
uniprot id: F8C2M5
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS06760
gene id: 795359:TOPB45_RS06760
uniprot id: F8C2C8
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS00030
gene id: 795359:TOPB45_RS00030
uniprot id: F8C1Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

795359:TOPB45 RS03825
gene id: 795359:TOPB45_RS03825
uniprot id: F8C571
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm

795359:TOPB45 RS02340
gene id: 795359:TOPB45_RS02340
uniprot id: F8C415
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

795359:TOPB45 RS03430
gene id: 795359:TOPB45_RS03430
uniprot id: F8C4X5
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS07950
gene id: 795359:TOPB45_RS07950
uniprot id: F8C3I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

795359:TOPB45 RS01370
gene id: 795359:TOPB45_RS01370
uniprot id: F8C364
names: Similarity
messages: Belongs to the LOG family.

795359:TOPB45 RS06890
gene id: 795359:TOPB45_RS06890
uniprot id: F8C2M0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

795359:TOPB45 RS05580
gene id: 795359:TOPB45_RS05580
uniprot id: F8C623
names: Similarity
messages: Belongs to the MEMO1 family.

795359:TOPB45 RS04390
gene id: 795359:TOPB45_RS04390
uniprot id: F8C5H1
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

795359:TOPB45 RS00475
gene id: 795359:TOPB45_RS00475
uniprot id: F8C252
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

795359:TOPB45 RS02770
gene id: 795359:TOPB45_RS02770
uniprot id: F8C4D0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

795359:TOPB45 RS06685
gene id: 795359:TOPB45_RS06685
uniprot id: F8C2B6
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

795359:TOPB45 RS03990
gene id: 795359:TOPB45_RS03990
uniprot id: F8C4G9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

795359:TOPB45 RS00900
gene id: 795359:TOPB45_RS00900
uniprot id: F8C464
names: Similarity
messages: Belongs to the HdrA family.

795359:TOPB45 RS07145
gene id: 795359:TOPB45_RS07145
uniprot id: F8C2R3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

795359:TOPB45 RS00650
gene id: 795359:TOPB45_RS00650
uniprot id: F8C2F4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

795359:TOPB45 RS07290
gene id: 795359:TOPB45_RS07290
uniprot id: F8C305
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

795359:TOPB45 RS04790
gene id: 795359:TOPB45_RS04790
uniprot id: F8C5P1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

795359:TOPB45 RS05275
gene id: 795359:TOPB45_RS05275
uniprot id: F8C5X5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

795359:TOPB45 RS06465
gene id: 795359:TOPB45_RS06465
uniprot id: F8C274
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

795359:TOPB45 RS06425
gene id: 795359:TOPB45_RS06425
uniprot id: F8C267
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS07500
gene id: 795359:TOPB45_RS07500
uniprot id: F8C343
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

795359:TOPB45 RS07795
gene id: 795359:TOPB45_RS07795
uniprot id: F8C3G4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS02620
gene id: 795359:TOPB45_RS02620
uniprot id: F8C4A4
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

795359:TOPB45 RS00505
gene id: 795359:TOPB45_RS00505
uniprot id: F8C258
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

795359:TOPB45 RS04305
gene id: 795359:TOPB45_RS04305
uniprot id: F8C5F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

795359:TOPB45 RS03000
gene id: 795359:TOPB45_RS03000
uniprot id: F8C4L0
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS01375
gene id: 795359:TOPB45_RS01375
uniprot id: F8C365
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

795359:TOPB45 RS06995
gene id: 795359:TOPB45_RS06995
uniprot id: F8C4U1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

795359:TOPB45 RS05775
gene id: 795359:TOPB45_RS05775
uniprot id: F8C655
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

795359:TOPB45 RS07780
gene id: 795359:TOPB45_RS07780
uniprot id: F8C3G2
names: Similarity
messages: Belongs to the GSP E family.

795359:TOPB45 RS02925
gene id: 795359:TOPB45_RS02925
uniprot id: F8C4J6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

795359:TOPB45 RS02220
gene id: 795359:TOPB45_RS02220
uniprot id: F8C3Z2
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

795359:TOPB45 RS07165
gene id: 795359:TOPB45_RS07165
uniprot id: F8C2R7
names: Similarity
messages: Belongs to the sigma-54 factor family.

795359:TOPB45 RS03980
gene id: 795359:TOPB45_RS03980
uniprot id: F8C5A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

795359:TOPB45 RS06185
gene id: 795359:TOPB45_RS06185
uniprot id: F8C1W0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

795359:TOPB45 RS07615
gene id: 795359:TOPB45_RS07615
uniprot id: F8C3D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

795359:TOPB45 RS06330
gene id: 795359:TOPB45_RS06330
uniprot id: F8C1Y1
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

795359:TOPB45 RS06380
gene id: 795359:TOPB45_RS06380
uniprot id: F8C1Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

795359:TOPB45 RS05510
gene id: 795359:TOPB45_RS05510
uniprot id: F8C615
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS04110
gene id: 795359:TOPB45_RS04110
uniprot id: F8C5C3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

795359:TOPB45 RS05060
gene id: 795359:TOPB45_RS05060
uniprot id: F8C5T8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

795359:TOPB45 RS04090
gene id: 795359:TOPB45_RS04090
uniprot id: F8C5B9
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS07650
gene id: 795359:TOPB45_RS07650
uniprot id: F8C3D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

795359:TOPB45 RS07630
gene id: 795359:TOPB45_RS07630
uniprot id: F8C3D4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

795359:TOPB45 RS03125
gene id: 795359:TOPB45_RS03125
uniprot id: F8C4N3
names: Similarity
messages: Belongs to the ParB family.

795359:TOPB45 RS05240
gene id: 795359:TOPB45_RS05240
uniprot id: F8C5W8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

795359:TOPB45 RS04510
gene id: 795359:TOPB45_RS04510
uniprot id: F8C5J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS00540
gene id: 795359:TOPB45_RS00540
uniprot id: F8C264
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

795359:TOPB45 RS06225
gene id: 795359:TOPB45_RS06225
uniprot id: F8C1W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

795359:TOPB45 RS00055
gene id: 795359:TOPB45_RS00055
uniprot id: F8C1Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

795359:TOPB45 RS00355
gene id: 795359:TOPB45_RS00355
uniprot id: F8C233
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

795359:TOPB45 RS01120
gene id: 795359:TOPB45_RS01120
uniprot id: F8C2V6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

795359:TOPB45 RS02120
gene id: 795359:TOPB45_RS02120
uniprot id: F8C3X4
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

795359:TOPB45 RS01365
gene id: 795359:TOPB45_RS01365
uniprot id: F8C363
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

795359:TOPB45 RS00080
gene id: 795359:TOPB45_RS00080
uniprot id: F8C1R3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

795359:TOPB45 RS01760
gene id: 795359:TOPB45_RS01760
uniprot id: F8C3J7
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

795359:TOPB45 RS07450
gene id: 795359:TOPB45_RS07450
uniprot id: F8C334
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

795359:TOPB45 RS02840
gene id: 795359:TOPB45_RS02840
uniprot id: F8C4E2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

795359:TOPB45 RS02930
gene id: 795359:TOPB45_RS02930
uniprot id: F8C4J7
names: Similarity
messages: Belongs to the UbiD family.

795359:TOPB45 RS09015
gene id: 795359:TOPB45_RS09015
uniprot id: F8C4I9
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

795359:TOPB45 RS03360
gene id: 795359:TOPB45_RS03360
uniprot id: F8C4W1
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.

795359:TOPB45 RS01540
gene id: 795359:TOPB45_RS01540
uniprot id: F8C396
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

795359:TOPB45 RS00465
gene id: 795359:TOPB45_RS00465
uniprot id: F8C458
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

795359:TOPB45 RS01485
gene id: 795359:TOPB45_RS01485
uniprot id: F8C387
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

795359:TOPB45 RS00435
gene id: 795359:TOPB45_RS00435
uniprot id: F8C455
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

795359:TOPB45 RS04680
gene id: 795359:TOPB45_RS04680
uniprot id: F8C5M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

795359:TOPB45 RS00200
gene id: 795359:TOPB45_RS00200
uniprot id: F8C204
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

795359:TOPB45 RS02295
gene id: 795359:TOPB45_RS02295
uniprot id: F8C407
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS01870
gene id: 795359:TOPB45_RS01870
uniprot id: F8C3L8
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

795359:TOPB45 RS06080
gene id: 795359:TOPB45_RS06080
uniprot id: F8C1U3
names: Similarity
messages: Belongs to the UPF0751 family.

795359:TOPB45 RS02535
gene id: 795359:TOPB45_RS02535
uniprot id: F8C488
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

795359:TOPB45 RS03900
gene id: 795359:TOPB45_RS03900
uniprot id: F8C585
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

795359:TOPB45 RS06455
gene id: 795359:TOPB45_RS06455
uniprot id: F8C273
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

795359:TOPB45 RS04345
gene id: 795359:TOPB45_RS04345
uniprot id: F8C4H4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

795359:TOPB45 RS01855
gene id: 795359:TOPB45_RS01855
uniprot id: F8C3L4
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

795359:TOPB45 RS08205
gene id: 795359:TOPB45_RS08205
uniprot id: F8C538
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

795359:TOPB45 RS04015
gene id: 795359:TOPB45_RS04015
uniprot id: F8C5A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

795359:TOPB45 RS04265
gene id: 795359:TOPB45_RS04265
uniprot id: F8C5E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

795359:TOPB45 RS08600
gene id: 795359:TOPB45_RS08600
uniprot id: F8C5M7
names: Similarity
messages: Belongs to the CsgA/CsgB family.

795359:TOPB45 RS05985
gene id: 795359:TOPB45_RS05985
uniprot id: F8C692
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

795359:TOPB45 RS02135
gene id: 795359:TOPB45_RS02135
uniprot id: F8C3X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

795359:TOPB45 RS05030
gene id: 795359:TOPB45_RS05030
uniprot id: F8C5T3
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS04275
gene id: 795359:TOPB45_RS04275
uniprot id: F8C5F1
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

795359:TOPB45 RS03335
gene id: 795359:TOPB45_RS03335
uniprot id: F8C4V7
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

795359:TOPB45 RS07970
gene id: 795359:TOPB45_RS07970
uniprot id: F8C3R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

795359:TOPB45 RS00235
gene id: 795359:TOPB45_RS00235
uniprot id: F8C211
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS07180
gene id: 795359:TOPB45_RS07180
uniprot id: F8C2R9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

795359:TOPB45 RS06510
gene id: 795359:TOPB45_RS06510
uniprot id: F8C283
names: Similarity
messages: Belongs to the P(II) protein family.

795359:TOPB45 RS04575
gene id: 795359:TOPB45_RS04575
uniprot id: F8C5K6
names: Similarity
messages: Belongs to the AOR/FOR family.

795359:TOPB45 RS03940
gene id: 795359:TOPB45_RS03940
uniprot id: F8C4G8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

795359:TOPB45 RS04070
gene id: 795359:TOPB45_RS04070
uniprot id: F8C5B6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

795359:TOPB45 RS06490
gene id: 795359:TOPB45_RS06490
uniprot id: F8C279
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

795359:TOPB45 RS01040
gene id: 795359:TOPB45_RS01040
uniprot id: F8C2U0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

795359:TOPB45 RS03460
gene id: 795359:TOPB45_RS03460
uniprot id: F8C4Y1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS06385
gene id: 795359:TOPB45_RS06385
uniprot id: F8C1Y8
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS00765
gene id: 795359:TOPB45_RS00765
uniprot id: F8C460
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

795359:TOPB45 RS07580
gene id: 795359:TOPB45_RS07580
uniprot id: F8C4U9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS03420
gene id: 795359:TOPB45_RS03420
uniprot id: F8C4X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

795359:TOPB45 RS05960
gene id: 795359:TOPB45_RS05960
uniprot id: F8C4S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

795359:TOPB45 RS07560
gene id: 795359:TOPB45_RS07560
uniprot id: F8C4U7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

795359:TOPB45 RS07390
gene id: 795359:TOPB45_RS07390
uniprot id: F8C324
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

795359:TOPB45 RS04915
gene id: 795359:TOPB45_RS04915
uniprot id: F8C5R6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

795359:TOPB45 RS07800
gene id: 795359:TOPB45_RS07800
uniprot id: F8C3G5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

795359:TOPB45 RS07075
gene id: 795359:TOPB45_RS07075
uniprot id: F8C2Q0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

795359:TOPB45 RS02140
gene id: 795359:TOPB45_RS02140
uniprot id: F8C3X7
names: Similarity
messages: Belongs to the bacterial glucokinase family.

795359:TOPB45 RS07220
gene id: 795359:TOPB45_RS07220
uniprot id: F8C2Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

795359:TOPB45 RS06770
gene id: 795359:TOPB45_RS06770
uniprot id: F8C2C9
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS02145
gene id: 795359:TOPB45_RS02145
uniprot id: F8C3X8
names: Similarity
messages: Belongs to the Skp family.

795359:TOPB45 RS02905
gene id: 795359:TOPB45_RS02905
uniprot id: F8C4J2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

795359:TOPB45 RS05925
gene id: 795359:TOPB45_RS05925
uniprot id: F8C681
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

795359:TOPB45 RS05970
gene id: 795359:TOPB45_RS05970
uniprot id: F8C689
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

795359:TOPB45 RS03285
gene id: 795359:TOPB45_RS03285
uniprot id: F8C4Q9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS04555
gene id: 795359:TOPB45_RS04555
uniprot id: F8C5K2
names: Similarity
messages: Belongs to the HupF/HypC family.

795359:TOPB45 RS03380
gene id: 795359:TOPB45_RS03380
uniprot id: F8C4W5
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

795359:TOPB45 RS01285
gene id: 795359:TOPB45_RS01285
uniprot id: F8C2X7
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

795359:TOPB45 RS03935
gene id: 795359:TOPB45_RS03935
uniprot id: F8C592
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

795359:TOPB45 RS00870
gene id: 795359:TOPB45_RS00870
uniprot id: F8C4G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

795359:TOPB45 RS06040
gene id: 795359:TOPB45_RS06040
uniprot id: F8C1T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

795359:TOPB45 RS07155
gene id: 795359:TOPB45_RS07155
uniprot id: F8C2R5
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

795359:TOPB45 RS07300
gene id: 795359:TOPB45_RS07300
uniprot id: F8C307
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

795359:TOPB45 RS02850
gene id: 795359:TOPB45_RS02850
uniprot id: F8C4E4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

795359:TOPB45 RS07925
gene id: 795359:TOPB45_RS07925
uniprot id: F8C3I1
names: Similarity
messages: Belongs to the archease family.

795359:TOPB45 RS03875
gene id: 795359:TOPB45_RS03875
uniprot id: F8C4G6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

795359:TOPB45 RS03260
gene id: 795359:TOPB45_RS03260
uniprot id: F8C4Q6
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS07430
gene id: 795359:TOPB45_RS07430
uniprot id: F8C330
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

795359:TOPB45 RS03880
gene id: 795359:TOPB45_RS03880
uniprot id: F8C582
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

795359:TOPB45 RS02810
gene id: 795359:TOPB45_RS02810
uniprot id: F8C4D6
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

795359:TOPB45 RS04880
gene id: 795359:TOPB45_RS04880
uniprot id: F8C5Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

795359:TOPB45 RS04140
gene id: 795359:TOPB45_RS04140
uniprot id: F8C5C9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

795359:TOPB45 RS05150
gene id: 795359:TOPB45_RS05150
uniprot id: F8C5V2
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS03165
gene id: 795359:TOPB45_RS03165
uniprot id: F8C4F8
names: Similarity
messages: Belongs to the CinA family.

795359:TOPB45 RS01270
gene id: 795359:TOPB45_RS01270
uniprot id: F8C2X5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

795359:TOPB45 RS02425
gene id: 795359:TOPB45_RS02425
uniprot id: F8C429
names: Similarity
messages: Belongs to the peptidase A31 family.

795359:TOPB45 RS08520
gene id: 795359:TOPB45_RS08520
uniprot id: F8C435
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

795359:TOPB45 RS04055
gene id: 795359:TOPB45_RS04055
uniprot id: F8C5B3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

795359:TOPB45 RS04320
gene id: 795359:TOPB45_RS04320
uniprot id: F8C5F9
names: Similarity
messages: Belongs to the peptidase S49 family.

795359:TOPB45 RS08360
gene id: 795359:TOPB45_RS08360
uniprot id: F8C442
names: Similarity
messages: Belongs to the class-I fumarase family.

795359:TOPB45 RS01065
gene id: 795359:TOPB45_RS01065
uniprot id: F8C2U5
names: Similarity
messages: Belongs to the UPF0047 family.

795359:TOPB45 RS00965
gene id: 795359:TOPB45_RS00965
uniprot id: F8C2S6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

795359:TOPB45 RS03525
gene id: 795359:TOPB45_RS03525
uniprot id: F8C4Z5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS06010
gene id: 795359:TOPB45_RS06010
uniprot id: F8C1S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

795359:TOPB45 RS00800
gene id: 795359:TOPB45_RS00800
uniprot id: F8C2I2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

795359:TOPB45 RS01615
gene id: 795359:TOPB45_RS01615
uniprot id: F8C3A7
names: Similarity
messages: Belongs to the arsA ATPase family.

795359:TOPB45 RS06335
gene id: 795359:TOPB45_RS06335
uniprot id: F8C4S9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

795359:TOPB45 RS00700
gene id: 795359:TOPB45_RS00700
uniprot id: F8C2G4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

795359:TOPB45 RS02530
gene id: 795359:TOPB45_RS02530
uniprot id: F8C487
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

795359:TOPB45 RS04005
gene id: 795359:TOPB45_RS04005
uniprot id: F8C5A4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

795359:TOPB45 RS07725
gene id: 795359:TOPB45_RS07725
uniprot id: F8C3F3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

795359:TOPB45 RS08190
gene id: 795359:TOPB45_RS08190
uniprot id: F8C3V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

795359:TOPB45 RS05205
gene id: 795359:TOPB45_RS05205
uniprot id: F8C5W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

795359:TOPB45 RS00675
gene id: 795359:TOPB45_RS00675
uniprot id: F8C2F9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

795359:TOPB45 RS06625
gene id: 795359:TOPB45_RS06625
uniprot id: F8C2A4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

795359:TOPB45 RS04940
gene id: 795359:TOPB45_RS04940
uniprot id: F8C5S1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

795359:TOPB45 RS06960
gene id: 795359:TOPB45_RS06960
uniprot id: F8C2N2
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

795359:TOPB45 RS08065
gene id: 795359:TOPB45_RS08065
uniprot id: F8C3T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

795359:TOPB45 RS07915
gene id: 795359:TOPB45_RS07915
uniprot id: F8C3I0
names: Similarity
messages: Belongs to the MotB family.

795359:TOPB45 RS02130
gene id: 795359:TOPB45_RS02130
uniprot id: F8C3X5
names: Similarity
messages: Belongs to the peptidase M16 family.

795359:TOPB45 RS00380
gene id: 795359:TOPB45_RS00380
uniprot id: F8C238
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

795359:TOPB45 RS07665
gene id: 795359:TOPB45_RS07665
uniprot id: F8C3E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

795359:TOPB45 RS04065
gene id: 795359:TOPB45_RS04065
uniprot id: F8C5B5
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

795359:TOPB45 RS02940
gene id: 795359:TOPB45_RS02940
uniprot id: F8C4J9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS02275
gene id: 795359:TOPB45_RS02275
uniprot id: F8C403
names: Similarity
messages: Belongs to the histone deacetylase family.

795359:TOPB45 RS05050
gene id: 795359:TOPB45_RS05050
uniprot id: F8C5T7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

795359:TOPB45 RS03315
gene id: 795359:TOPB45_RS03315
uniprot id: F8C4V3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS06635
gene id: 795359:TOPB45_RS06635
uniprot id: F8C2A6
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

795359:TOPB45 RS03265
gene id: 795359:TOPB45_RS03265
uniprot id: F8C4G1
names: Similarity
messages: Belongs to the UPF0111 family.

795359:TOPB45 RS02700
gene id: 795359:TOPB45_RS02700
uniprot id: F8C4C0
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

795359:TOPB45 RS04020
gene id: 795359:TOPB45_RS04020
uniprot id: F8C5A7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

795359:TOPB45 RS05780
gene id: 795359:TOPB45_RS05780
uniprot id: F8C656
names: Similarity
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.

795359:TOPB45 RS01925
gene id: 795359:TOPB45_RS01925
uniprot id: F8C3M9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

795359:TOPB45 RS03635
gene id: 795359:TOPB45_RS03635
uniprot id: F8C4G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

795359:TOPB45 RS05250
gene id: 795359:TOPB45_RS05250
uniprot id: F8C5X0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS04290
gene id: 795359:TOPB45_RS04290
uniprot id: F8C5F4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

795359:TOPB45 RS07760
gene id: 795359:TOPB45_RS07760
uniprot id: F8C3G0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

795359:TOPB45 RS00555
gene id: 795359:TOPB45_RS00555
uniprot id: F8C2D5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

795359:TOPB45 RS03675
gene id: 795359:TOPB45_RS03675
uniprot id: F8C542
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

795359:TOPB45 RS02865
gene id: 795359:TOPB45_RS02865
uniprot id: F8C4E7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

795359:TOPB45 RS07405
gene id: 795359:TOPB45_RS07405
uniprot id: F8C327
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

795359:TOPB45 RS03630
gene id: 795359:TOPB45_RS03630
uniprot id: F8C512
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

795359:TOPB45 RS06270
gene id: 795359:TOPB45_RS06270
uniprot id: F8C1X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

795359:TOPB45 RS04835
gene id: 795359:TOPB45_RS04835
uniprot id: F8C5Q0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS00180
gene id: 795359:TOPB45_RS00180
uniprot id: F8C200
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

795359:TOPB45 RS01385
gene id: 795359:TOPB45_RS01385
uniprot id: F8C367
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

795359:TOPB45 RS02200
gene id: 795359:TOPB45_RS02200
uniprot id: F8C3Y8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS04205
gene id: 795359:TOPB45_RS04205
uniprot id: F8C5E0
names: Similarity
messages: Belongs to the serpin family.

795359:TOPB45 RS01185
gene id: 795359:TOPB45_RS01185
uniprot id: F8C2W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

795359:TOPB45 RS04655
gene id: 795359:TOPB45_RS04655
uniprot id: F8C5M2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

795359:TOPB45 RS06590
gene id: 795359:TOPB45_RS06590
uniprot id: F8C299
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS02550
gene id: 795359:TOPB45_RS02550
uniprot id: F8C491
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

795359:TOPB45 RS03925
gene id: 795359:TOPB45_RS03925
uniprot id: F8C590
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

795359:TOPB45 RS03740
gene id: 795359:TOPB45_RS03740
uniprot id: F8C555
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS00500
gene id: 795359:TOPB45_RS00500
uniprot id: F8C257
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

795359:TOPB45 RS00110
gene id: 795359:TOPB45_RS00110
uniprot id: F8C1R9
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

795359:TOPB45 RS05310
gene id: 795359:TOPB45_RS05310
uniprot id: F8C5Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

795359:TOPB45 RS06975
gene id: 795359:TOPB45_RS06975
uniprot id: F8C4T9
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS04610
gene id: 795359:TOPB45_RS04610
uniprot id: F8C5L3
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS03145
gene id: 795359:TOPB45_RS03145
uniprot id: F8C4N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

795359:TOPB45 RS02895
gene id: 795359:TOPB45_RS02895
uniprot id: F8C4F2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

795359:TOPB45 RS02580
gene id: 795359:TOPB45_RS02580
uniprot id: F8C497
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

795359:TOPB45 RS08135
gene id: 795359:TOPB45_RS08135
uniprot id: F8C533
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

795359:TOPB45 RS04560
gene id: 795359:TOPB45_RS04560
uniprot id: F8C5K3
names: Similarity
messages: Belongs to the HypD family.

795359:TOPB45 RS00830
gene id: 795359:TOPB45_RS00830
uniprot id: F8C2I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

795359:TOPB45 RS00600
gene id: 795359:TOPB45_RS00600
uniprot id: F8C2E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

795359:TOPB45 RS05735
gene id: 795359:TOPB45_RS05735
uniprot id: F8C647
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

795359:TOPB45 RS05750
gene id: 795359:TOPB45_RS05750
uniprot id: F8C650
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

795359:TOPB45 RS05390
gene id: 795359:TOPB45_RS05390
uniprot id: F8C5Z7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

795359:TOPB45 RS03755
gene id: 795359:TOPB45_RS03755
uniprot id: F8C558
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

795359:TOPB45 RS06500
gene id: 795359:TOPB45_RS06500
uniprot id: F8C281
names: Function
names: Subunit
messages: Interacts with sigma-54.
messages: Required for activation of most nif operons, which are directly involved in nitrogen fixation.

795359:TOPB45 RS02780
gene id: 795359:TOPB45_RS02780
uniprot id: F8C4D1
names: Similarity
messages: Belongs to the ribF family.

795359:TOPB45 RS05585
gene id: 795359:TOPB45_RS05585
uniprot id: F8C4R8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

795359:TOPB45 RS08265
gene id: 795359:TOPB45_RS08265
uniprot id: F8C3W0
names: Similarity
messages: Belongs to the Fur family.

795359:TOPB45 RS03070
gene id: 795359:TOPB45_RS03070
uniprot id: F8C4M3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

795359:TOPB45 RS07105
gene id: 795359:TOPB45_RS07105
uniprot id: F8C4U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

795359:TOPB45 RS07370
gene id: 795359:TOPB45_RS07370
uniprot id: F8C320
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

795359:TOPB45 RS03720
gene id: 795359:TOPB45_RS03720
uniprot id: F8C551
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

795359:TOPB45 RS03965
gene id: 795359:TOPB45_RS03965
uniprot id: F8C597
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

795359:TOPB45 RS05525
gene id: 795359:TOPB45_RS05525
uniprot id: F8C617
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

795359:TOPB45 RS07980
gene id: 795359:TOPB45_RS07980
uniprot id: F8C3R3
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS00665
gene id: 795359:TOPB45_RS00665
uniprot id: F8C2F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

795359:TOPB45 RS05930
gene id: 795359:TOPB45_RS05930
uniprot id: F8C682
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

795359:TOPB45 RS05210
gene id: 795359:TOPB45_RS05210
uniprot id: F8C5W2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

795359:TOPB45 RS00795
gene id: 795359:TOPB45_RS00795
uniprot id: F8C461
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

795359:TOPB45 RS02825
gene id: 795359:TOPB45_RS02825
uniprot id: F8C4D9
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

795359:TOPB45 RS06150
gene id: 795359:TOPB45_RS06150
uniprot id: F8C1V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

795359:TOPB45 RS03915
gene id: 795359:TOPB45_RS03915
uniprot id: F8C588
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

795359:TOPB45 RS04280
gene id: 795359:TOPB45_RS04280
uniprot id: F8C5F2
names: Subunit
messages: Homodimer.

795359:TOPB45 RS08175
gene id: 795359:TOPB45_RS08175
uniprot id: F8C3U8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

795359:TOPB45 RS04845
gene id: 795359:TOPB45_RS04845
uniprot id: F8C5Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

795359:TOPB45 RS01075
gene id: 795359:TOPB45_RS01075
uniprot id: F8C2U7
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.

795359:TOPB45 RS04395
gene id: 795359:TOPB45_RS04395
uniprot id: F8C5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

795359:TOPB45 RS03455
gene id: 795359:TOPB45_RS03455
uniprot id: F8C4Y0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS05020
gene id: 795359:TOPB45_RS05020
uniprot id: F8C5T2
names: Similarity
messages: Belongs to the creatininase superfamily.

795359:TOPB45 RS01495
gene id: 795359:TOPB45_RS01495
uniprot id: F8C389
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

795359:TOPB45 RS00430
gene id: 795359:TOPB45_RS00430
uniprot id: F8C247
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

795359:TOPB45 RS00445
gene id: 795359:TOPB45_RS00445
uniprot id: F8C456
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

795359:TOPB45 RS07910
gene id: 795359:TOPB45_RS07910
uniprot id: F8C3H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

795359:TOPB45 RS07480
gene id: 795359:TOPB45_RS07480
uniprot id: F8C339
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

795359:TOPB45 RS04135
gene id: 795359:TOPB45_RS04135
uniprot id: F8C5C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS09160
gene id: 795359:TOPB45_RS09160
uniprot id: F8C5M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS02520
gene id: 795359:TOPB45_RS02520
uniprot id: F8C485
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

795359:TOPB45 RS07625
gene id: 795359:TOPB45_RS07625
uniprot id: F8C3D3
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS02575
gene id: 795359:TOPB45_RS02575
uniprot id: F8C496
names: Similarity
messages: Belongs to the CutA family.

795359:TOPB45 RS07355
gene id: 795359:TOPB45_RS07355
uniprot id: F8C318
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

795359:TOPB45 RS01000
gene id: 795359:TOPB45_RS01000
uniprot id: F8C2T2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS01045
gene id: 795359:TOPB45_RS01045
uniprot id: F8C2U1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

795359:TOPB45 RS01050
gene id: 795359:TOPB45_RS01050
uniprot id: F8C2U2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

795359:TOPB45 RS07520
gene id: 795359:TOPB45_RS07520
uniprot id: F8C347
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

795359:TOPB45 RS03295
gene id: 795359:TOPB45_RS03295
uniprot id: F8C4R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

795359:TOPB45 RS07060
gene id: 795359:TOPB45_RS07060
uniprot id: F8C2P8
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

795359:TOPB45 RS00295
gene id: 795359:TOPB45_RS00295
uniprot id: F8C221
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

795359:TOPB45 RS00360
gene id: 795359:TOPB45_RS00360
uniprot id: F8C234
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

795359:TOPB45 RS05495
gene id: 795359:TOPB45_RS05495
uniprot id: F8C612
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS04250
gene id: 795359:TOPB45_RS04250
uniprot id: F8C5E7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

795359:TOPB45 RS03120
gene id: 795359:TOPB45_RS03120
uniprot id: F8C4F6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

795359:TOPB45 RS03715
gene id: 795359:TOPB45_RS03715
uniprot id: F8C550
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

795359:TOPB45 RS07410
gene id: 795359:TOPB45_RS07410
uniprot id: F8C328
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

795359:TOPB45 RS04530
gene id: 795359:TOPB45_RS04530
uniprot id: F8C5J7
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS01845
gene id: 795359:TOPB45_RS01845
uniprot id: F8C3L2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

795359:TOPB45 RS05875
gene id: 795359:TOPB45_RS05875
uniprot id: F8C673
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

795359:TOPB45 RS00160
gene id: 795359:TOPB45_RS00160
uniprot id: F8C1Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

795359:TOPB45 RS01160
gene id: 795359:TOPB45_RS01160
uniprot id: F8C466
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

795359:TOPB45 RS08105
gene id: 795359:TOPB45_RS08105
uniprot id: F8C3T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

795359:TOPB45 RS07490
gene id: 795359:TOPB45_RS07490
uniprot id: F8C341
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS01570
gene id: 795359:TOPB45_RS01570
uniprot id: F8C3A0
names: Similarity
messages: Belongs to the FlgM family.

795359:TOPB45 RS07825
gene id: 795359:TOPB45_RS07825
uniprot id: F8C524
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.

795359:TOPB45 RS05235
gene id: 795359:TOPB45_RS05235
uniprot id: F8C5W7
names: Similarity
messages: Belongs to the peptidase S41A family.

795359:TOPB45 RS08115
gene id: 795359:TOPB45_RS08115
uniprot id: F8C3T9
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS03545
gene id: 795359:TOPB45_RS03545
uniprot id: F8C4Z8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

795359:TOPB45 RS07115
gene id: 795359:TOPB45_RS07115
uniprot id: F8C2Q7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS02270
gene id: 795359:TOPB45_RS02270
uniprot id: F8C402
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

795359:TOPB45 RS02290
gene id: 795359:TOPB45_RS02290
uniprot id: F8C406
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS05940
gene id: 795359:TOPB45_RS05940
uniprot id: F8C684
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

795359:TOPB45 RS07435
gene id: 795359:TOPB45_RS07435
uniprot id: F8C331
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

795359:TOPB45 RS03195
gene id: 795359:TOPB45_RS03195
uniprot id: F8C4P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS03815
gene id: 795359:TOPB45_RS03815
uniprot id: F8C569
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

795359:TOPB45 RS06485
gene id: 795359:TOPB45_RS06485
uniprot id: F8C278
names: Similarity
messages: Belongs to the glutamate synthase family.

795359:TOPB45 RS03840
gene id: 795359:TOPB45_RS03840
uniprot id: F8C574
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS04540
gene id: 795359:TOPB45_RS04540
uniprot id: F8C5J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

795359:TOPB45 RS08235
gene id: 795359:TOPB45_RS08235
uniprot id: F8C3V6
names: Similarity
messages: Belongs to the UPF0173 family.

795359:TOPB45 RS04850
gene id: 795359:TOPB45_RS04850
uniprot id: F8C5Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

795359:TOPB45 RS02420
gene id: 795359:TOPB45_RS02420
uniprot id: F8C428
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

795359:TOPB45 RS06640
gene id: 795359:TOPB45_RS06640
uniprot id: F8C2A7
names: Similarity
messages: Belongs to the peptidase S16 family.

795359:TOPB45 RS04935
gene id: 795359:TOPB45_RS04935
uniprot id: F8C5S0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

795359:TOPB45 RS05135
gene id: 795359:TOPB45_RS05135
uniprot id: F8C5U9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

795359:TOPB45 RS08925
gene id: 795359:TOPB45_RS08925
uniprot id: F8C3X9
names: Similarity
messages: Belongs to the Pal lipoprotein family.

795359:TOPB45 RS07955
gene id: 795359:TOPB45_RS07955
uniprot id: F8C3I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

795359:TOPB45 RS01465
gene id: 795359:TOPB45_RS01465
uniprot id: F8C383
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

795359:TOPB45 RS06495
gene id: 795359:TOPB45_RS06495
uniprot id: F8C280
names: Similarity
messages: Belongs to the glutamine synthetase family.

795359:TOPB45 RS06810
gene id: 795359:TOPB45_RS06810
uniprot id: F8C2K4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

795359:TOPB45 RS00815
gene id: 795359:TOPB45_RS00815
uniprot id: F8C2I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

795359:TOPB45 RS08095
gene id: 795359:TOPB45_RS08095
uniprot id: F8C3T6
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS02280
gene id: 795359:TOPB45_RS02280
uniprot id: F8C404
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

795359:TOPB45 RS00365
gene id: 795359:TOPB45_RS00365
uniprot id: F8C235
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

795359:TOPB45 RS05795
gene id: 795359:TOPB45_RS05795
uniprot id: F8C659
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS00310
gene id: 795359:TOPB45_RS00310
uniprot id: F8C224
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

795359:TOPB45 RS02870
gene id: 795359:TOPB45_RS02870
uniprot id: F8C4E8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

795359:TOPB45 RS01900
gene id: 795359:TOPB45_RS01900
uniprot id: F8C3M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

795359:TOPB45 RS08140
gene id: 795359:TOPB45_RS08140
uniprot id: F8C3U3
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

795359:TOPB45 RS03510
gene id: 795359:TOPB45_RS03510
uniprot id: F8C4Z2
names: Similarity
messages: Belongs to the fabD family.

795359:TOPB45 RS07225
gene id: 795359:TOPB45_RS07225
uniprot id: F8C2Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

795359:TOPB45 RS04925
gene id: 795359:TOPB45_RS04925
uniprot id: F8C5R8
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

795359:TOPB45 RS00305
gene id: 795359:TOPB45_RS00305
uniprot id: F8C223
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

795359:TOPB45 RS08460
gene id: 795359:TOPB45_RS08460
uniprot id: F8C2T5
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

795359:TOPB45 RS01415
gene id: 795359:TOPB45_RS01415
uniprot id: F8C373
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

795359:TOPB45 RS07710
gene id: 795359:TOPB45_RS07710
uniprot id: F8C3F0
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

795359:TOPB45 RS00970
gene id: 795359:TOPB45_RS00970
uniprot id: F8C2S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

795359:TOPB45 RS03640
gene id: 795359:TOPB45_RS03640
uniprot id: F8C513
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS06555
gene id: 795359:TOPB45_RS06555
uniprot id: F8C292
names: Similarity
messages: Belongs to the UPF0235 family.

795359:TOPB45 RS07660
gene id: 795359:TOPB45_RS07660
uniprot id: F8C3D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

795359:TOPB45 RS03725
gene id: 795359:TOPB45_RS03725
uniprot id: F8C552
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

795359:TOPB45 RS08605
gene id: 795359:TOPB45_RS08605
uniprot id: F8C5M9
names: Function
messages: May be involved in the biogenesis of curli organelles.

795359:TOPB45 RS02765
gene id: 795359:TOPB45_RS02765
uniprot id: F8C4C9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

795359:TOPB45 RS01840
gene id: 795359:TOPB45_RS01840
uniprot id: F8C3L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

795359:TOPB45 RS07285
gene id: 795359:TOPB45_RS07285
uniprot id: F8C304
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

795359:TOPB45 RS03680
gene id: 795359:TOPB45_RS03680
uniprot id: F8C543
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

795359:TOPB45 RS01835
gene id: 795359:TOPB45_RS01835
uniprot id: F8C3L0
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

795359:TOPB45 RS03155
gene id: 795359:TOPB45_RS03155
uniprot id: F8C4F7
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS01430
gene id: 795359:TOPB45_RS01430
uniprot id: F8C376
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

795359:TOPB45 RS07605
gene id: 795359:TOPB45_RS07605
uniprot id: F8C3C8
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

795359:TOPB45 RS03010
gene id: 795359:TOPB45_RS03010
uniprot id: F8C4L2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

795359:TOPB45 RS04545
gene id: 795359:TOPB45_RS04545
uniprot id: F8C5K0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

795359:TOPB45 RS05540
gene id: 795359:TOPB45_RS05540
uniprot id: F8C4R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

795359:TOPB45 RS03415
gene id: 795359:TOPB45_RS03415
uniprot id: F8C4X2
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

795359:TOPB45 RS06885
gene id: 795359:TOPB45_RS06885
uniprot id: F8C2L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

795359:TOPB45 RS03220
gene id: 795359:TOPB45_RS03220
uniprot id: F8C4P9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

795359:TOPB45 RS07195
gene id: 795359:TOPB45_RS07195
uniprot id: F8C2Y6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

795359:TOPB45 RS05545
gene id: 795359:TOPB45_RS05545
uniprot id: F8C619
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS04815
gene id: 795359:TOPB45_RS04815
uniprot id: F8C5P6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

795359:TOPB45 RS01055
gene id: 795359:TOPB45_RS01055
uniprot id: F8C2U3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

795359:TOPB45 RS00385
gene id: 795359:TOPB45_RS00385
uniprot id: F8C239
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

795359:TOPB45 RS06240
gene id: 795359:TOPB45_RS06240
uniprot id: F8C1W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

795359:TOPB45 RS06050
gene id: 795359:TOPB45_RS06050
uniprot id: F8C1T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

795359:TOPB45 RS07765
gene id: 795359:TOPB45_RS07765
uniprot id: F8C521
names: Similarity
messages: Belongs to the UDPGP type 2 family.

795359:TOPB45 RS01880
gene id: 795359:TOPB45_RS01880
uniprot id: F8C3M0
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS00625
gene id: 795359:TOPB45_RS00625
uniprot id: F8C2E9
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

795359:TOPB45 RS00560
gene id: 795359:TOPB45_RS00560
uniprot id: F8C2D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

795359:TOPB45 RS00100
gene id: 795359:TOPB45_RS00100
uniprot id: F8C1R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

795359:TOPB45 RS08060
gene id: 795359:TOPB45_RS08060
uniprot id: F8C3S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: Periplasm
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

795359:TOPB45 RS06155
gene id: 795359:TOPB45_RS06155
uniprot id: F8C1V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

795359:TOPB45 RS03190
gene id: 795359:TOPB45_RS03190
uniprot id: F8C4P3
names: Similarity
messages: Belongs to the universal stress protein A family.

795359:TOPB45 RS04060
gene id: 795359:TOPB45_RS04060
uniprot id: F8C5B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

795359:TOPB45 RS02435
gene id: 795359:TOPB45_RS02435
uniprot id: F8C431
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS00955
gene id: 795359:TOPB45_RS00955
uniprot id: F8C2S4
names: Similarity
messages: Belongs to the universal stress protein A family.

795359:TOPB45 RS00840
gene id: 795359:TOPB45_RS00840
uniprot id: F8C2I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

795359:TOPB45 RS07100
gene id: 795359:TOPB45_RS07100
uniprot id: F8C2Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

795359:TOPB45 RS08045
gene id: 795359:TOPB45_RS08045
uniprot id: F8C3S6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

795359:TOPB45 RS04125
gene id: 795359:TOPB45_RS04125
uniprot id: F8C5C6
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

795359:TOPB45 RS07150
gene id: 795359:TOPB45_RS07150
uniprot id: F8C2R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

795359:TOPB45 RS08445
gene id: 795359:TOPB45_RS08445
uniprot id: F8C248
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

795359:TOPB45 RS07125
gene id: 795359:TOPB45_RS07125
uniprot id: F8C2Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

795359:TOPB45 RS06875
gene id: 795359:TOPB45_RS06875
uniprot id: F8C2L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

795359:TOPB45 RS02860
gene id: 795359:TOPB45_RS02860
uniprot id: F8C4E6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

795359:TOPB45 RS04890
gene id: 795359:TOPB45_RS04890
uniprot id: F8C5R1
names: Similarity
messages: Belongs to the MEMO1 family.

795359:TOPB45 RS03565
gene id: 795359:TOPB45_RS03565
uniprot id: F8C502
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

795359:TOPB45 RS03015
gene id: 795359:TOPB45_RS03015
uniprot id: F8C4L3
names: Similarity
messages: Belongs to the RuvC family.

795359:TOPB45 RS06750
gene id: 795359:TOPB45_RS06750
uniprot id: F8C2C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

795359:TOPB45 RS07720
gene id: 795359:TOPB45_RS07720
uniprot id: F8C3F2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

795359:TOPB45 RS06855
gene id: 795359:TOPB45_RS06855
uniprot id: F8C2L3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

795359:TOPB45 RS04840
gene id: 795359:TOPB45_RS04840
uniprot id: F8C5Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

795359:TOPB45 RS07735
gene id: 795359:TOPB45_RS07735
uniprot id: F8C3F5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS05245
gene id: 795359:TOPB45_RS05245
uniprot id: F8C5W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

795359:TOPB45 RS01635
gene id: 795359:TOPB45_RS01635
uniprot id: F8C3B0
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS06190
gene id: 795359:TOPB45_RS06190
uniprot id: F8C1W1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

795359:TOPB45 RS03970
gene id: 795359:TOPB45_RS03970
uniprot id: F8C598
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

795359:TOPB45 RS03685
gene id: 795359:TOPB45_RS03685
uniprot id: F8C544
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

795359:TOPB45 RS00300
gene id: 795359:TOPB45_RS00300
uniprot id: F8C222
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

795359:TOPB45 RS08100
gene id: 795359:TOPB45_RS08100
uniprot id: F8C3T7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS00140
gene id: 795359:TOPB45_RS00140
uniprot id: F8C1S5
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

795359:TOPB45 RS02060
gene id: 795359:TOPB45_RS02060
uniprot id: F8C3P9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

795359:TOPB45 RS04725
gene id: 795359:TOPB45_RS04725
uniprot id: F8C5N1
names: Similarity
messages: Belongs to the GSP E family.

795359:TOPB45 RS06530
gene id: 795359:TOPB45_RS06530
uniprot id: F8C287
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

795359:TOPB45 RS04130
gene id: 795359:TOPB45_RS04130
uniprot id: F8C5C7
names: Similarity
messages: Belongs to the Ahb/Nir family.

795359:TOPB45 RS03920
gene id: 795359:TOPB45_RS03920
uniprot id: F8C589
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

795359:TOPB45 RS08480
gene id: 795359:TOPB45_RS08480
uniprot id: F8C375
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

795359:TOPB45 RS00845
gene id: 795359:TOPB45_RS00845
uniprot id: F8C2J0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

795359:TOPB45 RS03180
gene id: 795359:TOPB45_RS03180
uniprot id: F8C4P1
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

795359:TOPB45 RS08575
gene id: 795359:TOPB45_RS08575
uniprot id: F8C5H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

795359:TOPB45 RS01165
gene id: 795359:TOPB45_RS01165
uniprot id: F8C2W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

795359:TOPB45 RS02745
gene id: 795359:TOPB45_RS02745
uniprot id: F8C4C5
names: Similarity
messages: Belongs to the PstS family.

795359:TOPB45 RS02215
gene id: 795359:TOPB45_RS02215
uniprot id: F8C3Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

795359:TOPB45 RS04855
gene id: 795359:TOPB45_RS04855
uniprot id: F8C5Q4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS01720
gene id: 795359:TOPB45_RS01720
uniprot id: F8C3I9
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS07015
gene id: 795359:TOPB45_RS07015
uniprot id: F8C2N9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

795359:TOPB45 RS07935
gene id: 795359:TOPB45_RS07935
uniprot id: F8C3I3
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

795359:TOPB45 RS05570
gene id: 795359:TOPB45_RS05570
uniprot id: F8C4R7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

795359:TOPB45 RS03115
gene id: 795359:TOPB45_RS03115
uniprot id: F8C4N2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

795359:TOPB45 RS04730
gene id: 795359:TOPB45_RS04730
uniprot id: F8C5N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

795359:TOPB45 RS06345
gene id: 795359:TOPB45_RS06345
uniprot id: F8C1Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

795359:TOPB45 RS08275
gene id: 795359:TOPB45_RS08275
uniprot id: F8C3W1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

795359:TOPB45 RS04025
gene id: 795359:TOPB45_RS04025
uniprot id: F8C5A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

795359:TOPB45 RS02945
gene id: 795359:TOPB45_RS02945
uniprot id: F8C4K0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

795359:TOPB45 RS00725
gene id: 795359:TOPB45_RS00725
uniprot id: F8C2H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

795359:TOPB45 RS02820
gene id: 795359:TOPB45_RS02820
uniprot id: F8C4D8
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

795359:TOPB45 RS00855
gene id: 795359:TOPB45_RS00855
uniprot id: F8C2J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

795359:TOPB45 RS04860
gene id: 795359:TOPB45_RS04860
uniprot id: F8C5Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

795359:TOPB45 RS02110
gene id: 795359:TOPB45_RS02110
uniprot id: F8C476
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

795359:TOPB45 RS00095
gene id: 795359:TOPB45_RS00095
uniprot id: F8C1R6
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS00115
gene id: 795359:TOPB45_RS00115
uniprot id: F8C1S0
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

795359:TOPB45 RS00975
gene id: 795359:TOPB45_RS00975
uniprot id: F8C2S8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

795359:TOPB45 RS04535
gene id: 795359:TOPB45_RS04535
uniprot id: F8C5J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

795359:TOPB45 RS01030
gene id: 795359:TOPB45_RS01030
uniprot id: F8C2T8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

795359:TOPB45 RS08310
gene id: 795359:TOPB45_RS08310
uniprot id: F8C541
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS08000
gene id: 795359:TOPB45_RS08000
uniprot id: F8C3R7
names: Similarity
messages: Belongs to the threonine synthase family.

795359:TOPB45 RS06520
gene id: 795359:TOPB45_RS06520
uniprot id: F8C285
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

795359:TOPB45 RS05080
gene id: 795359:TOPB45_RS05080
uniprot id: F8C5U2
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

795359:TOPB45 RS03975
gene id: 795359:TOPB45_RS03975
uniprot id: F8C599
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

795359:TOPB45 RS05200
gene id: 795359:TOPB45_RS05200
uniprot id: F8C5W0
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

795359:TOPB45 RS08625
gene id: 795359:TOPB45_RS08625
uniprot id: F8C675
names: Similarity
messages: Belongs to the UPF0111 family.

795359:TOPB45 RS04310
gene id: 795359:TOPB45_RS04310
uniprot id: F8C5F7
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

795359:TOPB45 RS04050
gene id: 795359:TOPB45_RS04050
uniprot id: F8C5B2
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

795359:TOPB45 RS00745
gene id: 795359:TOPB45_RS00745
uniprot id: F8C2H4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

795359:TOPB45 RS03895
gene id: 795359:TOPB45_RS03895
uniprot id: F8C584
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

795359:TOPB45 RS02085
gene id: 795359:TOPB45_RS02085
uniprot id: F8C3Q4
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

795359:TOPB45 RS05845
gene id: 795359:TOPB45_RS05845
uniprot id: F8C669
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS00205
gene id: 795359:TOPB45_RS00205
uniprot id: F8C205
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

795359:TOPB45 RS07920
gene id: 795359:TOPB45_RS07920
uniprot id: F8C531
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

795359:TOPB45 RS06265
gene id: 795359:TOPB45_RS06265
uniprot id: F8C1X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane

795359:TOPB45 RS06690
gene id: 795359:TOPB45_RS06690
uniprot id: F8C2B7
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

795359:TOPB45 RS01355
gene id: 795359:TOPB45_RS01355
uniprot id: F8C361
names: Subcellular Location Annotation
messages: Periplasm

795359:TOPB45 RS05360
gene id: 795359:TOPB45_RS05360
uniprot id: F8C5Z2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

795359:TOPB45 RS06650
gene id: 795359:TOPB45_RS06650
uniprot id: F8C2A9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

795359:TOPB45 RS06575
gene id: 795359:TOPB45_RS06575
uniprot id: F8C296
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the AccA family.
messages: In the N-terminal section; belongs to the AccD/PCCB family.

795359:TOPB45 RS07035
gene id: 795359:TOPB45_RS07035
uniprot id: F8C2P3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

795359:TOPB45 RS03775
gene id: 795359:TOPB45_RS03775
uniprot id: F8C562
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

795359:TOPB45 RS06565
gene id: 795359:TOPB45_RS06565
uniprot id: F8C294
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

795359:TOPB45 RS05230
gene id: 795359:TOPB45_RS05230
uniprot id: F8C5W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS07040
gene id: 795359:TOPB45_RS07040
uniprot id: F8C2P4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

795359:TOPB45 RS02480
gene id: 795359:TOPB45_RS02480
uniprot id: F8C481
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

795359:TOPB45 RS03885
gene id: 795359:TOPB45_RS03885
uniprot id: F8C583
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

795359:TOPB45 RS02460
gene id: 795359:TOPB45_RS02460
uniprot id: F8C479
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

795359:TOPB45 RS06860
gene id: 795359:TOPB45_RS06860
uniprot id: F8C2L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

795359:TOPB45 RS02360
gene id: 795359:TOPB45_RS02360
uniprot id: F8C418
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

795359:TOPB45 RS03945
gene id: 795359:TOPB45_RS03945
uniprot id: F8C593
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

795359:TOPB45 RS04425
gene id: 795359:TOPB45_RS04425
uniprot id: F8C5H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

795359:TOPB45 RS04340
gene id: 795359:TOPB45_RS04340
uniprot id: F8C5G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

795359:TOPB45 RS00195
gene id: 795359:TOPB45_RS00195
uniprot id: F8C203
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

795359:TOPB45 RS03330
gene id: 795359:TOPB45_RS03330
uniprot id: F8C4V6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

795359:TOPB45 RS01550
gene id: 795359:TOPB45_RS01550
uniprot id: F8C471
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

795359:TOPB45 RS09055
gene id: 795359:TOPB45_RS09055
uniprot id: F8C3S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

795359:TOPB45 RS04330
gene id: 795359:TOPB45_RS04330
uniprot id: F8C5G1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

795359:TOPB45 RS01170
gene id: 795359:TOPB45_RS01170
uniprot id: F8C2W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

795359:TOPB45 RS02970
gene id: 795359:TOPB45_RS02970
uniprot id: F8C4K5
names: Similarity
messages: Belongs to the hemerythrin family.

795359:TOPB45 RS02365
gene id: 795359:TOPB45_RS02365
uniprot id: F8C419
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

795359:TOPB45 RS08405
gene id: 795359:TOPB45_RS08405
uniprot id: F8C451
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

795359:TOPB45 RS06130
gene id: 795359:TOPB45_RS06130
uniprot id: F8C1V3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

795359:TOPB45 RS05025
gene id: 795359:TOPB45_RS05025
uniprot id: F8C4I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

795359:TOPB45 RS05910
gene id: 795359:TOPB45_RS05910
uniprot id: F8C679
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

795359:TOPB45 RS00645
gene id: 795359:TOPB45_RS00645
uniprot id: F8C2F3
names: Similarity
messages: Belongs to the peptidase U62 family.

795359:TOPB45 RS09070
gene id: 795359:TOPB45_RS09070
uniprot id: F8C263
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

795359:TOPB45 RS05530
gene id: 795359:TOPB45_RS05530
uniprot id: F8C4R3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

795359:TOPB45 RS05350
gene id: 795359:TOPB45_RS05350
uniprot id: F8C5Z0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

795359:TOPB45 RS04360
gene id: 795359:TOPB45_RS04360
uniprot id: F8C5G6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS06470
gene id: 795359:TOPB45_RS06470
uniprot id: F8C275
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS06420
gene id: 795359:TOPB45_RS06420
uniprot id: F8C266
names: Similarity
messages: Belongs to the universal stress protein A family.

795359:TOPB45 RS04690
gene id: 795359:TOPB45_RS04690
uniprot id: F8C5M6
names: Similarity
messages: Belongs to the CsgA/CsgB family.

795359:TOPB45 RS04355
gene id: 795359:TOPB45_RS04355
uniprot id: F8C5G5
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

795359:TOPB45 RS01450
gene id: 795359:TOPB45_RS01450
uniprot id: F8C380
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS02815
gene id: 795359:TOPB45_RS02815
uniprot id: F8C4D7
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

795359:TOPB45 RS07395
gene id: 795359:TOPB45_RS07395
uniprot id: F8C325
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS05515
gene id: 795359:TOPB45_RS05515
uniprot id: F8C616
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS07210
gene id: 795359:TOPB45_RS07210
uniprot id: F8C2Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

795359:TOPB45 RS06000
gene id: 795359:TOPB45_RS06000
uniprot id: F8C1S7
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

795359:TOPB45 RS00400
gene id: 795359:TOPB45_RS00400
uniprot id: F8C242
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS03020
gene id: 795359:TOPB45_RS03020
uniprot id: F8C4L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

795359:TOPB45 RS08905
gene id: 795359:TOPB45_RS08905
uniprot id: F8C351
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

795359:TOPB45 RS04875
gene id: 795359:TOPB45_RS04875
uniprot id: F8C5Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

795359:TOPB45 RS06735
gene id: 795359:TOPB45_RS06735
uniprot id: F8C2C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS03095
gene id: 795359:TOPB45_RS03095
uniprot id: F8C4M8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS07485
gene id: 795359:TOPB45_RS07485
uniprot id: F8C340
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS01585
gene id: 795359:TOPB45_RS01585
uniprot id: F8C3A3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

795359:TOPB45 RS09155
gene id: 795359:TOPB45_RS09155
uniprot id: F8C5L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS05575
gene id: 795359:TOPB45_RS05575
uniprot id: F8C622
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

795359:TOPB45 RS01395
gene id: 795359:TOPB45_RS01395
uniprot id: F8C369
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

795359:TOPB45 RS07960
gene id: 795359:TOPB45_RS07960
uniprot id: F8C3I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

795359:TOPB45 RS01125
gene id: 795359:TOPB45_RS01125
uniprot id: F8C2V7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

795359:TOPB45 RS03730
gene id: 795359:TOPB45_RS03730
uniprot id: F8C553
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS04000
gene id: 795359:TOPB45_RS04000
uniprot id: F8C5A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

795359:TOPB45 RS04920
gene id: 795359:TOPB45_RS04920
uniprot id: F8C5R7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS07440
gene id: 795359:TOPB45_RS07440
uniprot id: F8C332
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

795359:TOPB45 RS02355
gene id: 795359:TOPB45_RS02355
uniprot id: F8C477
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS05980
gene id: 795359:TOPB45_RS05980
uniprot id: F8C691
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

795359:TOPB45 RS03075
gene id: 795359:TOPB45_RS03075
uniprot id: F8C4M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

795359:TOPB45 RS05215
gene id: 795359:TOPB45_RS05215
uniprot id: F8C5W3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

795359:TOPB45 RS03240
gene id: 795359:TOPB45_RS03240
uniprot id: F8C4Q3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

795359:TOPB45 RS01545
gene id: 795359:TOPB45_RS01545
uniprot id: F8C397
names: Similarity
messages: Belongs to the GPI family.

795359:TOPB45 RS08165
gene id: 795359:TOPB45_RS08165
uniprot id: F8C535
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS03670
gene id: 795359:TOPB45_RS03670
uniprot id: F8C520
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

795359:TOPB45 RS01850
gene id: 795359:TOPB45_RS01850
uniprot id: F8C3L3
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

795359:TOPB45 RS07350
gene id: 795359:TOPB45_RS07350
uniprot id: F8C317
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

795359:TOPB45 RS02005
gene id: 795359:TOPB45_RS02005
uniprot id: F8C3P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

795359:TOPB45 RS03215
gene id: 795359:TOPB45_RS03215
uniprot id: F8C4P8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

795359:TOPB45 RS07050
gene id: 795359:TOPB45_RS07050
uniprot id: F8C2P6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

795359:TOPB45 RS05260
gene id: 795359:TOPB45_RS05260
uniprot id: F8C5X2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

795359:TOPB45 RS08255
gene id: 795359:TOPB45_RS08255
uniprot id: F8C3V8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

795359:TOPB45 RS05195
gene id: 795359:TOPB45_RS05195
uniprot id: F8C5V9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

795359:TOPB45 RS06645
gene id: 795359:TOPB45_RS06645
uniprot id: F8C2A8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

795359:TOPB45 RS07415
gene id: 795359:TOPB45_RS07415
uniprot id: F8C329
names: Similarity
messages: Belongs to the peptidase M18 family.

795359:TOPB45 RS05900
gene id: 795359:TOPB45_RS05900
uniprot id: F8C4S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

795359:TOPB45 RS04030
gene id: 795359:TOPB45_RS04030
uniprot id: F8C5A9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

795359:TOPB45 RS01100
gene id: 795359:TOPB45_RS01100
uniprot id: F8C2V2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

795359:TOPB45 RS06025
gene id: 795359:TOPB45_RS06025
uniprot id: F8C1T2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Membrane

795359:TOPB45 RS00620
gene id: 795359:TOPB45_RS00620
uniprot id: F8C2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

795359:TOPB45 RS01590
gene id: 795359:TOPB45_RS01590
uniprot id: F8C3A4
names: Similarity
messages: Belongs to the acylphosphatase family.

795359:TOPB45 RS07890
gene id: 795359:TOPB45_RS07890
uniprot id: F8C3H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

795359:TOPB45 RS08430
gene id: 795359:TOPB45_RS08430
uniprot id: F8C210
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

795359:TOPB45 RS02920
gene id: 795359:TOPB45_RS02920
uniprot id: F8C4J5
names: Similarity
messages: Belongs to the peptidase U62 family.

795359:TOPB45 RS08390
gene id: 795359:TOPB45_RS08390
uniprot id: F8C448
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

795359:TOPB45 RS03030
gene id: 795359:TOPB45_RS03030
uniprot id: F8C4L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

795359:TOPB45 RS04255
gene id: 795359:TOPB45_RS04255
uniprot id: F8C5E8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

795359:TOPB45 RS02445
gene id: 795359:TOPB45_RS02445
uniprot id: F8C433
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS05220
gene id: 795359:TOPB45_RS05220
uniprot id: F8C5W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

795359:TOPB45 RS01685
gene id: 795359:TOPB45_RS01685
uniprot id: F8C3B9
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

795359:TOPB45 RS00130
gene id: 795359:TOPB45_RS00130
uniprot id: F8C1S3
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

795359:TOPB45 RS01330
gene id: 795359:TOPB45_RS01330
uniprot id: F8C357
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

795359:TOPB45 RS00670
gene id: 795359:TOPB45_RS00670
uniprot id: F8C2F8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

795359:TOPB45 RS07620
gene id: 795359:TOPB45_RS07620
uniprot id: F8C3D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

795359:TOPB45 RS04115
gene id: 795359:TOPB45_RS04115
uniprot id: F8C5C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

795359:TOPB45 RS00695
gene id: 795359:TOPB45_RS00695
uniprot id: F8C2G3
names: Caution
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

795359:TOPB45 RS02935
gene id: 795359:TOPB45_RS02935
uniprot id: F8C4J8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

795359:TOPB45 RS06630
gene id: 795359:TOPB45_RS06630
uniprot id: F8C2A5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

795359:TOPB45 RS04035
gene id: 795359:TOPB45_RS04035
uniprot id: F8C5B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

795359:TOPB45 RS06850
gene id: 795359:TOPB45_RS06850
uniprot id: F8C2L2
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

795359:TOPB45 RS01220
gene id: 795359:TOPB45_RS01220
uniprot id: F8C2X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

795359:TOPB45 RS07260
gene id: 795359:TOPB45_RS07260
uniprot id: F8C2Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

795359:TOPB45 RS03325
gene id: 795359:TOPB45_RS03325
uniprot id: F8C4V5
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

795359:TOPB45 RS01920
gene id: 795359:TOPB45_RS01920
uniprot id: F8C3M8
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

795359:TOPB45 RS04515
gene id: 795359:TOPB45_RS04515
uniprot id: F8C5J4
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS03255
gene id: 795359:TOPB45_RS03255
uniprot id: F8C4Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

795359:TOPB45 RS06045
gene id: 795359:TOPB45_RS06045
uniprot id: F8C1T6
names: Similarity
messages: Belongs to the RemA family.

795359:TOPB45 RS02660
gene id: 795359:TOPB45_RS02660
uniprot id: F8C4B2
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS03535
gene id: 795359:TOPB45_RS03535
uniprot id: F8C4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

795359:TOPB45 RS00510
gene id: 795359:TOPB45_RS00510
uniprot id: F8C459
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

795359:TOPB45 RS08300
gene id: 795359:TOPB45_RS08300
uniprot id: F8C540
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

795359:TOPB45 RS00120
gene id: 795359:TOPB45_RS00120
uniprot id: F8C1S1
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

795359:TOPB45 RS00155
gene id: 795359:TOPB45_RS00155
uniprot id: F8C1Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

795359:TOPB45 RS03745
gene id: 795359:TOPB45_RS03745
uniprot id: F8C556
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

795359:TOPB45 RS05805
gene id: 795359:TOPB45_RS05805
uniprot id: F8C661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Membrane

795359:TOPB45 RS03370
gene id: 795359:TOPB45_RS03370
uniprot id: F8C4W3
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

795359:TOPB45 RS01515
gene id: 795359:TOPB45_RS01515
uniprot id: F8C393
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

795359:TOPB45 RS01500
gene id: 795359:TOPB45_RS01500
uniprot id: F8C390
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

795359:TOPB45 RS06950
gene id: 795359:TOPB45_RS06950
uniprot id: F8C2N0
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

795359:TOPB45 RS00425
gene id: 795359:TOPB45_RS00425
uniprot id: F8C246
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

795359:TOPB45 RS00470
gene id: 795359:TOPB45_RS00470
uniprot id: F8C251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Membrane

795359:TOPB45 RS03735
gene id: 795359:TOPB45_RS03735
uniprot id: F8C554
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

795359:TOPB45 RS03910
gene id: 795359:TOPB45_RS03910
uniprot id: F8C587
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

795359:TOPB45 RS02095
gene id: 795359:TOPB45_RS02095
uniprot id: F8C3Q6
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

795359:TOPB45 RS03490
gene id: 795359:TOPB45_RS03490
uniprot id: F8C4Y7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS00125
gene id: 795359:TOPB45_RS00125
uniprot id: F8C1S2
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

795359:TOPB45 RS03960
gene id: 795359:TOPB45_RS03960
uniprot id: F8C596
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

795359:TOPB45 RS00825
gene id: 795359:TOPB45_RS00825
uniprot id: F8C2I6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

795359:TOPB45 RS00315
gene id: 795359:TOPB45_RS00315
uniprot id: F8C225
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

795359:TOPB45 RS06865
gene id: 795359:TOPB45_RS06865
uniprot id: F8C2L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Membrane

795359:TOPB45 RS03390
gene id: 795359:TOPB45_RS03390
uniprot id: F8C4W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

795359:TOPB45 RS01510
gene id: 795359:TOPB45_RS01510
uniprot id: F8C392
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS05745
gene id: 795359:TOPB45_RS05745
uniprot id: F8C649
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

795359:TOPB45 RS09010
gene id: 795359:TOPB45_RS09010
uniprot id: F8C5V3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

795359:TOPB45 RS05375
gene id: 795359:TOPB45_RS05375
uniprot id: F8C5Z5
names: Similarity
messages: Belongs to the pyruvate kinase family.

795359:TOPB45 RS05550
gene id: 795359:TOPB45_RS05550
uniprot id: F8C4R5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

795359:TOPB45 RS01295
gene id: 795359:TOPB45_RS01295
uniprot id: F8C2X9
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS06415
gene id: 795359:TOPB45_RS06415
uniprot id: F8C265
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

795359:TOPB45 RS01215
gene id: 795359:TOPB45_RS01215
uniprot id: F8C2X1
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

795359:TOPB45 RS02430
gene id: 795359:TOPB45_RS02430
uniprot id: F8C430
names: Similarity
messages: Belongs to the universal stress protein A family.

795359:TOPB45 RS06745
gene id: 795359:TOPB45_RS06745
uniprot id: F8C2C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

795359:TOPB45 RS06665
gene id: 795359:TOPB45_RS06665
uniprot id: F8C2B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS02675
gene id: 795359:TOPB45_RS02675
uniprot id: F8C4B5
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS01010
gene id: 795359:TOPB45_RS01010
uniprot id: F8C2T4
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

795359:TOPB45 RS01945
gene id: 795359:TOPB45_RS01945
uniprot id: F8C3N3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS05790
gene id: 795359:TOPB45_RS05790
uniprot id: F8C658
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

795359:TOPB45 RS03590
gene id: 795359:TOPB45_RS03590
uniprot id: F8C506
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

795359:TOPB45 RS08370
gene id: 795359:TOPB45_RS08370
uniprot id: F8C444
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS05730
gene id: 795359:TOPB45_RS05730
uniprot id: F8C646
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

795359:TOPB45 RS02250
gene id: 795359:TOPB45_RS02250
uniprot id: F8C3Z8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS06410
gene id: 795359:TOPB45_RS06410
uniprot id: F8C1Z3
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

795359:TOPB45 RS03230
gene id: 795359:TOPB45_RS03230
uniprot id: F8C4Q1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

795359:TOPB45 RS03850
gene id: 795359:TOPB45_RS03850
uniprot id: F8C576
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

795359:TOPB45 RS04800
gene id: 795359:TOPB45_RS04800
uniprot id: F8C5P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

795359:TOPB45 RS00595
gene id: 795359:TOPB45_RS00595
uniprot id: F8C2E3
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS00605
gene id: 795359:TOPB45_RS00605
uniprot id: F8C2E5
names: Similarity
messages: Belongs to the thioredoxin family.

795359:TOPB45 RS07975
gene id: 795359:TOPB45_RS07975
uniprot id: F8C3R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

795359:TOPB45 RS02845
gene id: 795359:TOPB45_RS02845
uniprot id: F8C4E3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

795359:TOPB45 RS07380
gene id: 795359:TOPB45_RS07380
uniprot id: F8C322
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

795359:TOPB45 RS00390
gene id: 795359:TOPB45_RS00390
uniprot id: F8C240
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

795359:TOPB45 RS02610
gene id: 795359:TOPB45_RS02610
uniprot id: F8C4A2
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS06895
gene id: 795359:TOPB45_RS06895
uniprot id: F8C2M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

795359:TOPB45 RS04400
gene id: 795359:TOPB45_RS04400
uniprot id: F8C4H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

795359:TOPB45 RS07275
gene id: 795359:TOPB45_RS07275
uniprot id: F8C302
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

795359:TOPB45 RS00495
gene id: 795359:TOPB45_RS00495
uniprot id: F8C256
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

795359:TOPB45 RS05345
gene id: 795359:TOPB45_RS05345
uniprot id: F8C5Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

795359:TOPB45 RS01260
gene id: 795359:TOPB45_RS01260
uniprot id: F8C2X4
names: Similarity
messages: Belongs to the hemerythrin family.

795359:TOPB45 RS07810
gene id: 795359:TOPB45_RS07810
uniprot id: F8C3G7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

795359:TOPB45 RS03855
gene id: 795359:TOPB45_RS03855
uniprot id: F8C577
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS06395
gene id: 795359:TOPB45_RS06395
uniprot id: F8C1Z0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

795359:TOPB45 RS03905
gene id: 795359:TOPB45_RS03905
uniprot id: F8C586
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

795359:TOPB45 RS07945
gene id: 795359:TOPB45_RS07945
uniprot id: F8C3I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

795359:TOPB45 RS06935
gene id: 795359:TOPB45_RS06935
uniprot id: F8C2M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

795359:TOPB45 RS00480
gene id: 795359:TOPB45_RS00480
uniprot id: F8C253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

795359:TOPB45 RS08120
gene id: 795359:TOPB45_RS08120
uniprot id: F8C3U0
names: Subcellular Location Annotation
messages: Cytoplasm

795359:TOPB45 RS03150
gene id: 795359:TOPB45_RS03150
uniprot id: F8C4N8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

795359:TOPB45 RS07020
gene id: 795359:TOPB45_RS07020
uniprot id: F8C2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

795359:TOPB45 RS03065
gene id: 795359:TOPB45_RS03065
uniprot id: F8C4M2
names: Similarity
messages: Belongs to the TrpC family.

795359:TOPB45 RS02165
gene id: 795359:TOPB45_RS02165
uniprot id: F8C3Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

795359:TOPB45 RS03340
gene id: 795359:TOPB45_RS03340
uniprot id: F8C4V8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

795359:TOPB45 RS00395
gene id: 795359:TOPB45_RS00395
uniprot id: F8C241
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

795359:TOPB45 RS07885
gene id: 795359:TOPB45_RS07885
uniprot id: F8C529
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

795359:TOPB45 RS03930
gene id: 795359:TOPB45_RS03930
uniprot id: F8C591
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

795359:TOPB45 RS01290
gene id: 795359:TOPB45_RS01290
uniprot id: F8C2X8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

795359:TOPB45 RS00405
gene id: 795359:TOPB45_RS00405
uniprot id: F8C243
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

795359:TOPB45 RS01325
gene id: 795359:TOPB45_RS01325
uniprot id: F8C356
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

795359:TOPB45 RS08200
gene id: 795359:TOPB45_RS08200
uniprot id: F8C3V1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

795359:TOPB45 RS01930
gene id: 795359:TOPB45_RS01930
uniprot id: F8C3N0
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

795359:TOPB45 RS02525
gene id: 795359:TOPB45_RS02525
uniprot id: F8C486
names: Similarity
messages: Belongs to the UPF0045 family.

795359:TOPB45 RS05535
gene id: 795359:TOPB45_RS05535
uniprot id: F8C618
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS08530
gene id: 795359:TOPB45_RS08530
uniprot id: F8C482
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS00075
gene id: 795359:TOPB45_RS00075
uniprot id: F8C1R2
names: Similarity
messages: Belongs to the LacAB/RpiB family.

795359:TOPB45 RS04720
gene id: 795359:TOPB45_RS04720
uniprot id: F8C5N0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS06870
gene id: 795359:TOPB45_RS06870
uniprot id: F8C2L6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

795359:TOPB45 RS02090
gene id: 795359:TOPB45_RS02090
uniprot id: F8C3Q5
names: Similarity
messages: Belongs to the RecJ family.

795359:TOPB45 RS08400
gene id: 795359:TOPB45_RS08400
uniprot id: F8C450
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

795359:TOPB45 RS02545
gene id: 795359:TOPB45_RS02545
uniprot id: F8C490
names: Subcellular Location Annotation
messages: Membrane

795359:TOPB45 RS06110
gene id: 795359:TOPB45_RS06110
uniprot id: F8C1U9
names: Similarity
messages: Belongs to the OprB family.

795359:TOPB45 RS02785
gene id: 795359:TOPB45_RS02785
uniprot id: F8C4F5
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

795359:TOPB45 RS04085
gene id: 795359:TOPB45_RS04085
uniprot id: F8C5B8
names: Similarity
messages: Belongs to the Ahb/Nir family.

795359:TOPB45 RS01275
gene id: 795359:TOPB45_RS01275
uniprot id: F8C469
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS07550
gene id: 795359:TOPB45_RS07550
uniprot id: F8C352
names: Subcellular Location Annotation
messages: Mitochondrion

795359:TOPB45 RS03760
gene id: 795359:TOPB45_RS03760
uniprot id: F8C559
names: Similarity
messages: Belongs to the aspartokinase family.

795359:TOPB45 RS06620
gene id: 795359:TOPB45_RS06620
uniprot id: F8C2A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

795359:TOPB45 RS03570
gene id: 795359:TOPB45_RS03570
uniprot id: F8C503
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

795359:TOPB45 RS00865
gene id: 795359:TOPB45_RS00865
uniprot id: F8C2J3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

795359:TOPB45 RS05490
gene id: 795359:TOPB45_RS05490
uniprot id: F8C611
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

795359:TOPB45 RS02225
gene id: 795359:TOPB45_RS02225
uniprot id: F8C3Z3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

795359:TOPB45 RS04565
gene id: 795359:TOPB45_RS04565
uniprot id: F8C5K4
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

795359:TOPB45 RS01940
gene id: 795359:TOPB45_RS01940
uniprot id: F8C3N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

795359:TOPB45 RS02800
gene id: 795359:TOPB45_RS02800
uniprot id: F8C4D4
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

795359:TOPB45 RS06675
gene id: 795359:TOPB45_RS06675
uniprot id: F8C2B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

795359:TOPB45 RS02605
gene id: 795359:TOPB45_RS02605
uniprot id: F8C4A1
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

795359:TOPB45 RS03055
gene id: 795359:TOPB45_RS03055
uniprot id: F8C4M0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

795359:TOPB45 RS05825
gene id: 795359:TOPB45_RS05825
uniprot id: F8C665
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

795359:TOPB45 RS02350
gene id: 795359:TOPB45_RS02350
uniprot id: F8C417
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS07940
gene id: 795359:TOPB45_RS07940
uniprot id: F8C3I4
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

795359:TOPB45 RS03235
gene id: 795359:TOPB45_RS03235
uniprot id: F8C4Q2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

795359:TOPB45 RS00250
gene id: 795359:TOPB45_RS00250
uniprot id: F8C214
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

795359:TOPB45 RS07130
gene id: 795359:TOPB45_RS07130
uniprot id: F8C2R0
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

795359:TOPB45 RS04865
gene id: 795359:TOPB45_RS04865
uniprot id: F8C5Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

795359:TOPB45 RS05185
gene id: 795359:TOPB45_RS05185
uniprot id: F8C5V7
names: Similarity
messages: Belongs to the transglycosylase Slt family.

795359:TOPB45 RS03695
gene id: 795359:TOPB45_RS03695
uniprot id: F8C546
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

795359:TOPB45 RS02075
gene id: 795359:TOPB45_RS02075
uniprot id: F8C3Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

795359:TOPB45 RS06560
gene id: 795359:TOPB45_RS06560
uniprot id: F8C293
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS08075
gene id: 795359:TOPB45_RS08075
uniprot id: F8C3T2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

795359:TOPB45 RS06105
gene id: 795359:TOPB45_RS06105
uniprot id: F8C1U8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

795359:TOPB45 RS00790
gene id: 795359:TOPB45_RS00790
uniprot id: F8C2I1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

795359:TOPB45 RS05955
gene id: 795359:TOPB45_RS05955
uniprot id: F8C687
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

795359:TOPB45 RS07750
gene id: 795359:TOPB45_RS07750
uniprot id: F8C3F8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS07005
gene id: 795359:TOPB45_RS07005
uniprot id: F8C2N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

795359:TOPB45 RS01200
gene id: 795359:TOPB45_RS01200
uniprot id: F8C2W9
names: Similarity
messages: Belongs to the class-I fumarase family.

795359:TOPB45 RS00085
gene id: 795359:TOPB45_RS00085
uniprot id: F8C1R4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

795359:TOPB45 RS01625
gene id: 795359:TOPB45_RS01625
uniprot id: F8C3A8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

795359:TOPB45 RS07730
gene id: 795359:TOPB45_RS07730
uniprot id: F8C3F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

795359:TOPB45 RS00340
gene id: 795359:TOPB45_RS00340
uniprot id: F8C230
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

795359:TOPB45 RS01115
gene id: 795359:TOPB45_RS01115
uniprot id: F8C2V5
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

795359:TOPB45 RS03645
gene id: 795359:TOPB45_RS03645
uniprot id: F8C515
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

795359:TOPB45 RS03445
gene id: 795359:TOPB45_RS03445
uniprot id: F8C4X8
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes the interconversion of UDP-D-glucuronic acid (UDP-GlcA) and UDP-D-galacturonic acid (UDP-GalA).

795359:TOPB45 RS02485
gene id: 795359:TOPB45_RS02485
uniprot id: F8C437
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

795359:TOPB45 RS07845
gene id: 795359:TOPB45_RS07845
uniprot id: F8C525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

795359:TOPB45 RS08385
gene id: 795359:TOPB45_RS08385
uniprot id: F8C447
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

795359:TOPB45 RS01560
gene id: 795359:TOPB45_RS01560
uniprot id: F8C399
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS02995
gene id: 795359:TOPB45_RS02995
uniprot id: F8C4K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

795359:TOPB45 RS05770
gene id: 795359:TOPB45_RS05770
uniprot id: F8C654
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

795359:TOPB45 RS02400
gene id: 795359:TOPB45_RS02400
uniprot id: F8C424
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

795359:TOPB45 RS06955
gene id: 795359:TOPB45_RS06955
uniprot id: F8C2N1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS00185
gene id: 795359:TOPB45_RS00185
uniprot id: F8C201
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

795359:TOPB45 RS02180
gene id: 795359:TOPB45_RS02180
uniprot id: F8C3Y4
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.