768672:DESFE RS05370
gene id: 768672:DESFE_RS05370
uniprot id: I3XSN0
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS05430
gene id: 768672:DESFE_RS05430
uniprot id: I3XSP1
names: Similarity
messages: Belongs to the AOR/FOR family.

768672:DESFE RS06755
gene id: 768672:DESFE_RS06755
uniprot id: I3XTD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

768672:DESFE RS05400
gene id: 768672:DESFE_RS05400
uniprot id: I3XSN6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS01215
gene id: 768672:DESFE_RS01215
uniprot id: I3XQC6
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03445
gene id: 768672:DESFE_RS03445
uniprot id: I3XRL6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

768672:DESFE RS02525
gene id: 768672:DESFE_RS02525
uniprot id: I3XR33
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

768672:DESFE RS07045
gene id: 768672:DESFE_RS07045
uniprot id: I3XTI6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

768672:DESFE RS04055
gene id: 768672:DESFE_RS04055
uniprot id: I3XRY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS03345
gene id: 768672:DESFE_RS03345
uniprot id: I3XRJ6
names: Similarity
messages: Belongs to the GcvT family.

768672:DESFE RS06530
gene id: 768672:DESFE_RS06530
uniprot id: I3XT91
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

768672:DESFE RS01900
gene id: 768672:DESFE_RS01900
uniprot id: I3XQR3
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

768672:DESFE RS02985
gene id: 768672:DESFE_RS02985
uniprot id: I3XRC5
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

768672:DESFE RS00995
gene id: 768672:DESFE_RS00995
uniprot id: I3XQ82
names: Similarity
messages: Belongs to the phosphohexose mutase family.

768672:DESFE RS07430
gene id: 768672:DESFE_RS07430
uniprot id: I3XTR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

768672:DESFE RS01825
gene id: 768672:DESFE_RS01825
uniprot id: I3XQP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS03940
gene id: 768672:DESFE_RS03940
uniprot id: I3XRW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

768672:DESFE RS03855
gene id: 768672:DESFE_RS03855
uniprot id: I3XRU5
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03955
gene id: 768672:DESFE_RS03955
uniprot id: I3XRW4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS07480
gene id: 768672:DESFE_RS07480
uniprot id: I3XSK9
names: Similarity
messages: Belongs to the UPF0251 family.

768672:DESFE RS01680
gene id: 768672:DESFE_RS01680
uniprot id: I3XQL9
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

768672:DESFE RS00060
gene id: 768672:DESFE_RS00060
uniprot id: I3XPQ0
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

768672:DESFE RS05545
gene id: 768672:DESFE_RS05545
uniprot id: I3XSR4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

768672:DESFE RS01615
gene id: 768672:DESFE_RS01615
uniprot id: I3XQK6
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

768672:DESFE RS04295
gene id: 768672:DESFE_RS04295
uniprot id: I3XS34
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03180
gene id: 768672:DESFE_RS03180
uniprot id: I3XRG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Membrane

768672:DESFE RS06435
gene id: 768672:DESFE_RS06435
uniprot id: I3XT72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

768672:DESFE RS06990
gene id: 768672:DESFE_RS06990
uniprot id: I3XTH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS02925
gene id: 768672:DESFE_RS02925
uniprot id: I3XRB3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

768672:DESFE RS03440
gene id: 768672:DESFE_RS03440
uniprot id: I3XRL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

768672:DESFE RS07035
gene id: 768672:DESFE_RS07035
uniprot id: I3XTI4
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

768672:DESFE RS03290
gene id: 768672:DESFE_RS03290
uniprot id: I3XRI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

768672:DESFE RS05740
gene id: 768672:DESFE_RS05740
uniprot id: I3XSU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

768672:DESFE RS07310
gene id: 768672:DESFE_RS07310
uniprot id: I3XTN7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

768672:DESFE RS01715
gene id: 768672:DESFE_RS01715
uniprot id: I3XQM6
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

768672:DESFE RS04730
gene id: 768672:DESFE_RS04730
uniprot id: I3XSB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

768672:DESFE RS01685
gene id: 768672:DESFE_RS01685
uniprot id: I3XQM0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS03130
gene id: 768672:DESFE_RS03130
uniprot id: I3XRF3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

768672:DESFE RS05745
gene id: 768672:DESFE_RS05745
uniprot id: I3XSU8
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS01180
gene id: 768672:DESFE_RS01180
uniprot id: I3XQB9
names: Similarity
messages: Belongs to the glutaredoxin family.

768672:DESFE RS05765
gene id: 768672:DESFE_RS05765
uniprot id: I3XSV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

768672:DESFE RS05290
gene id: 768672:DESFE_RS05290
uniprot id: I3XSL5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS00255
gene id: 768672:DESFE_RS00255
uniprot id: G4JRM5
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

768672:DESFE RS04680
gene id: 768672:DESFE_RS04680
uniprot id: I3XSA7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

768672:DESFE RS06430
gene id: 768672:DESFE_RS06430
uniprot id: I3XT71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS03540
gene id: 768672:DESFE_RS03540
uniprot id: I3XRN5
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

768672:DESFE RS07150
gene id: 768672:DESFE_RS07150
uniprot id: I3XTK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

768672:DESFE RS00455
gene id: 768672:DESFE_RS00455
uniprot id: I3XPX6
names: Similarity
messages: Belongs to the HypE family.

768672:DESFE RS02385
gene id: 768672:DESFE_RS02385
uniprot id: I3XR05
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

768672:DESFE RS05750
gene id: 768672:DESFE_RS05750
uniprot id: I3XSU9
names: Similarity
messages: Belongs to the type IA topoisomerase family.

768672:DESFE RS04290
gene id: 768672:DESFE_RS04290
uniprot id: I3XS33
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

768672:DESFE RS07380
gene id: 768672:DESFE_RS07380
uniprot id: I3XTQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

768672:DESFE RS00625
gene id: 768672:DESFE_RS00625
uniprot id: I3XQ11
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

768672:DESFE RS06150
gene id: 768672:DESFE_RS06150
uniprot id: I3XT24
names: Similarity
messages: Belongs to the PDCD5 family.

768672:DESFE RS06270
gene id: 768672:DESFE_RS06270
uniprot id: I3XT42
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

768672:DESFE RS05275
gene id: 768672:DESFE_RS05275
uniprot id: I3XSL2
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

768672:DESFE RS00980
gene id: 768672:DESFE_RS00980
uniprot id: I3XQ79
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

768672:DESFE RS05170
gene id: 768672:DESFE_RS05170
uniprot id: I3XSJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

768672:DESFE RS04350
gene id: 768672:DESFE_RS04350
uniprot id: I3XS44
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

768672:DESFE RS03610
gene id: 768672:DESFE_RS03610
uniprot id: I3XRP9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS04230
gene id: 768672:DESFE_RS04230
uniprot id: I3XS21
names: Similarity
messages: Belongs to the DtxR/MntR family.

768672:DESFE RS07270
gene id: 768672:DESFE_RS07270
uniprot id: I3XTM9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

768672:DESFE RS06045
gene id: 768672:DESFE_RS06045
uniprot id: I3XT03
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS06620
gene id: 768672:DESFE_RS06620
uniprot id: I3XTA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

768672:DESFE RS06380
gene id: 768672:DESFE_RS06380
uniprot id: I3XT61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

768672:DESFE RS07185
gene id: 768672:DESFE_RS07185
uniprot id: I3XTL2
names: Similarity
messages: Belongs to the SDO1/SBDS family.

768672:DESFE RS01820
gene id: 768672:DESFE_RS01820
uniprot id: I3XQP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS04115
gene id: 768672:DESFE_RS04115
uniprot id: I3XRZ7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

768672:DESFE RS03870
gene id: 768672:DESFE_RS03870
uniprot id: I3XRU8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

768672:DESFE RS03295
gene id: 768672:DESFE_RS03295
uniprot id: I3XRI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS00825
gene id: 768672:DESFE_RS00825
uniprot id: I3XQ49
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS03730
gene id: 768672:DESFE_RS03730
uniprot id: I3XRS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

768672:DESFE RS04245
gene id: 768672:DESFE_RS04245
uniprot id: I3XS24
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

768672:DESFE RS07265
gene id: 768672:DESFE_RS07265
uniprot id: I3XTM7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

768672:DESFE RS06315
gene id: 768672:DESFE_RS06315
uniprot id: I3XT51
names: Similarity
messages: Belongs to the peptidase S8 family.

768672:DESFE RS05300
gene id: 768672:DESFE_RS05300
uniprot id: I3XSL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS06715
gene id: 768672:DESFE_RS06715
uniprot id: I3XTC7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

768672:DESFE RS06900
gene id: 768672:DESFE_RS06900
uniprot id: I3XTF9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

768672:DESFE RS02110
gene id: 768672:DESFE_RS02110
uniprot id: I3XQV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

768672:DESFE RS00480
gene id: 768672:DESFE_RS00480
uniprot id: I3XPY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

768672:DESFE RS07440
gene id: 768672:DESFE_RS07440
uniprot id: I3XTR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

768672:DESFE RS06470
gene id: 768672:DESFE_RS06470
uniprot id: I3XT79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

768672:DESFE RS04750
gene id: 768672:DESFE_RS04750
uniprot id: I3XSC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

768672:DESFE RS07025
gene id: 768672:DESFE_RS07025
uniprot id: I3XTI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

768672:DESFE RS00785
gene id: 768672:DESFE_RS00785
uniprot id: I3XQ41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

768672:DESFE RS00790
gene id: 768672:DESFE_RS00790
uniprot id: I3XQ42
names: Similarity
messages: Belongs to the SUI1 family.

768672:DESFE RS02905
gene id: 768672:DESFE_RS02905
uniprot id: I3XRA9
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

768672:DESFE RS04300
gene id: 768672:DESFE_RS04300
uniprot id: I3XS35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS07315
gene id: 768672:DESFE_RS07315
uniprot id: I3XTN8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

768672:DESFE RS05025
gene id: 768672:DESFE_RS05025
uniprot id: I3XSH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

768672:DESFE RS05375
gene id: 768672:DESFE_RS05375
uniprot id: I3XSN1
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03620
gene id: 768672:DESFE_RS03620
uniprot id: I3XRQ1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

768672:DESFE RS03810
gene id: 768672:DESFE_RS03810
uniprot id: I3XRT6
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

768672:DESFE RS01845
gene id: 768672:DESFE_RS01845
uniprot id: I3XQQ2
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

768672:DESFE RS01710
gene id: 768672:DESFE_RS01710
uniprot id: I3XQM5
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

768672:DESFE RS01760
gene id: 768672:DESFE_RS01760
uniprot id: I3XQN5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS02720
gene id: 768672:DESFE_RS02720
uniprot id: I3XR74
names: Similarity
messages: Belongs to the UPF0201 family.

768672:DESFE RS00020
gene id: 768672:DESFE_RS00020
uniprot id: I3XPP4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS00985
gene id: 768672:DESFE_RS00985
uniprot id: I3XQ80
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

768672:DESFE RS04705
gene id: 768672:DESFE_RS04705
uniprot id: I3XSB1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

768672:DESFE RS03635
gene id: 768672:DESFE_RS03635
uniprot id: I3XRQ4
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS02805
gene id: 768672:DESFE_RS02805
uniprot id: I3XR90
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03895
gene id: 768672:DESFE_RS03895
uniprot id: I3XRV2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

768672:DESFE RS02040
gene id: 768672:DESFE_RS02040
uniprot id: I3XQU0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

768672:DESFE RS06030
gene id: 768672:DESFE_RS06030
uniprot id: I3XT01
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS07295
gene id: 768672:DESFE_RS07295
uniprot id: I3XTN4
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

768672:DESFE RS04045
gene id: 768672:DESFE_RS04045
uniprot id: I3XRY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

768672:DESFE RS01055
gene id: 768672:DESFE_RS01055
uniprot id: I3XQ94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS02820
gene id: 768672:DESFE_RS02820
uniprot id: I3XR93
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS02500
gene id: 768672:DESFE_RS02500
uniprot id: I3XR28
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

768672:DESFE RS06420
gene id: 768672:DESFE_RS06420
uniprot id: I3XT69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

768672:DESFE RS06945
gene id: 768672:DESFE_RS06945
uniprot id: I3XTG7
names: Similarity
messages: Belongs to the peptidase S8 family.

768672:DESFE RS01665
gene id: 768672:DESFE_RS01665
uniprot id: I3XQL6
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

768672:DESFE RS07285
gene id: 768672:DESFE_RS07285
uniprot id: I3XTN2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

768672:DESFE RS02270
gene id: 768672:DESFE_RS02270
uniprot id: I3XQY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

768672:DESFE RS02505
gene id: 768672:DESFE_RS02505
uniprot id: I3XR29
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

768672:DESFE RS07190
gene id: 768672:DESFE_RS07190
uniprot id: I3XTL3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

768672:DESFE RS04255
gene id: 768672:DESFE_RS04255
uniprot id: I3XS26
names: Similarity
messages: Belongs to the HypD family.

768672:DESFE RS00095
gene id: 768672:DESFE_RS00095
uniprot id: I3XPQ7
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS00035
gene id: 768672:DESFE_RS00035
uniprot id: I3XPP5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

768672:DESFE RS00055
gene id: 768672:DESFE_RS00055
uniprot id: I3XPP9
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

768672:DESFE RS04635
gene id: 768672:DESFE_RS04635
uniprot id: I3XS98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

768672:DESFE RS04930
gene id: 768672:DESFE_RS04930
uniprot id: I3XSF3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

768672:DESFE RS02460
gene id: 768672:DESFE_RS02460
uniprot id: I3XR21
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

768672:DESFE RS06395
gene id: 768672:DESFE_RS06395
uniprot id: I3XT64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

768672:DESFE RS07260
gene id: 768672:DESFE_RS07260
uniprot id: I3XTM6
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

768672:DESFE RS06855
gene id: 768672:DESFE_RS06855
uniprot id: I3XTF1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS01060
gene id: 768672:DESFE_RS01060
uniprot id: I3XQ95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

768672:DESFE RS06350
gene id: 768672:DESFE_RS06350
uniprot id: I3XT55
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

768672:DESFE RS06390
gene id: 768672:DESFE_RS06390
uniprot id: I3XT63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

768672:DESFE RS02990
gene id: 768672:DESFE_RS02990
uniprot id: I3XRC6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

768672:DESFE RS05975
gene id: 768672:DESFE_RS05975
uniprot id: I3XSZ0
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

768672:DESFE RS07570
gene id: 768672:DESFE_RS07570
uniprot id: I3XTM8
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS00890
gene id: 768672:DESFE_RS00890
uniprot id: I3XQ61
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS01335
gene id: 768672:DESFE_RS01335
uniprot id: I3XQE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

768672:DESFE RS06100
gene id: 768672:DESFE_RS06100
uniprot id: I3XT14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

768672:DESFE RS05910
gene id: 768672:DESFE_RS05910
uniprot id: I3XSX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

768672:DESFE RS03605
gene id: 768672:DESFE_RS03605
uniprot id: I3XRP8
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03795
gene id: 768672:DESFE_RS03795
uniprot id: I3XRT3
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS04815
gene id: 768672:DESFE_RS04815
uniprot id: I3XSD4
names: Similarity
messages: Belongs to the UPF0047 family.

768672:DESFE RS00150
gene id: 768672:DESFE_RS00150
uniprot id: I3XPR6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

768672:DESFE RS07200
gene id: 768672:DESFE_RS07200
uniprot id: I3XTL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

768672:DESFE RS02175
gene id: 768672:DESFE_RS02175
uniprot id: I3XQW6
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

768672:DESFE RS00525
gene id: 768672:DESFE_RS00525
uniprot id: I3XPZ0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

768672:DESFE RS01590
gene id: 768672:DESFE_RS01590
uniprot id: I3XQK1
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

768672:DESFE RS07375
gene id: 768672:DESFE_RS07375
uniprot id: I3XTQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS00860
gene id: 768672:DESFE_RS00860
uniprot id: I3XQ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS05790
gene id: 768672:DESFE_RS05790
uniprot id: I3XSV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

768672:DESFE RS03970
gene id: 768672:DESFE_RS03970
uniprot id: I3XRW6
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS07425
gene id: 768672:DESFE_RS07425
uniprot id: I3XTQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

768672:DESFE RS04060
gene id: 768672:DESFE_RS04060
uniprot id: I3XRY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

768672:DESFE RS00550
gene id: 768672:DESFE_RS00550
uniprot id: I3XPZ6
names: Similarity
messages: Belongs to the carbamate kinase family.

768672:DESFE RS07170
gene id: 768672:DESFE_RS07170
uniprot id: I3XTK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

768672:DESFE RS01780
gene id: 768672:DESFE_RS01780
uniprot id: I3XQN9
names: Similarity
messages: Belongs to the glycosyl hydrolase 53 family.

768672:DESFE RS00570
gene id: 768672:DESFE_RS00570
uniprot id: I3XQ00
names: Similarity
messages: Belongs to the phosphohexose mutase family.

768672:DESFE RS06535
gene id: 768672:DESFE_RS06535
uniprot id: I3XT92
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

768672:DESFE RS02380
gene id: 768672:DESFE_RS02380
uniprot id: I3XR04
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

768672:DESFE RS06995
gene id: 768672:DESFE_RS06995
uniprot id: I3XTH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

768672:DESFE RS06015
gene id: 768672:DESFE_RS06015
uniprot id: I3XSZ8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

768672:DESFE RS06445
gene id: 768672:DESFE_RS06445
uniprot id: I3XT74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS06145
gene id: 768672:DESFE_RS06145
uniprot id: I3XT23
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

768672:DESFE RS05515
gene id: 768672:DESFE_RS05515
uniprot id: I3XSQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

768672:DESFE RS01075
gene id: 768672:DESFE_RS01075
uniprot id: I3XQ98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

768672:DESFE RS00275
gene id: 768672:DESFE_RS00275
uniprot id: I3XPU0
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

768672:DESFE RS03500
gene id: 768672:DESFE_RS03500
uniprot id: I3XRM7
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

768672:DESFE RS00425
gene id: 768672:DESFE_RS00425
uniprot id: I3XPW9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS01330
gene id: 768672:DESFE_RS01330
uniprot id: I3XQE8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

768672:DESFE RS05605
gene id: 768672:DESFE_RS05605
uniprot id: I3XSS6
names: Similarity
messages: Belongs to the PGI/PMI family.

768672:DESFE RS05560
gene id: 768672:DESFE_RS05560
uniprot id: I3XSR7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

768672:DESFE RS05735
gene id: 768672:DESFE_RS05735
uniprot id: I3XSU6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

768672:DESFE RS07345
gene id: 768672:DESFE_RS07345
uniprot id: I3XTP4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

768672:DESFE RS07325
gene id: 768672:DESFE_RS07325
uniprot id: I3XTP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

768672:DESFE RS07105
gene id: 768672:DESFE_RS07105
uniprot id: I3XTJ8
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS04585
gene id: 768672:DESFE_RS04585
uniprot id: I3XS90
names: Similarity
messages: Belongs to the hemerythrin family.

768672:DESFE RS02300
gene id: 768672:DESFE_RS02300
uniprot id: I3XQY9
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

768672:DESFE RS06870
gene id: 768672:DESFE_RS06870
uniprot id: I3XTF4
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

768672:DESFE RS00090
gene id: 768672:DESFE_RS00090
uniprot id: I3XPQ6
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS00340
gene id: 768672:DESFE_RS00340
uniprot id: I3XPV2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

768672:DESFE RS05895
gene id: 768672:DESFE_RS05895
uniprot id: I3XSX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS01635
gene id: 768672:DESFE_RS01635
uniprot id: I3XQL0
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS04375
gene id: 768672:DESFE_RS04375
uniprot id: I3XS47
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

768672:DESFE RS05435
gene id: 768672:DESFE_RS05435
uniprot id: U3GKX6
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.

768672:DESFE RS07365
gene id: 768672:DESFE_RS07365
uniprot id: I3XTP8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

768672:DESFE RS07235
gene id: 768672:DESFE_RS07235
uniprot id: I3XTM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

768672:DESFE RS05295
gene id: 768672:DESFE_RS05295
uniprot id: I3XSL6
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS07405
gene id: 768672:DESFE_RS07405
uniprot id: I3XTQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS06360
gene id: 768672:DESFE_RS06360
uniprot id: I3XT57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

768672:DESFE RS05395
gene id: 768672:DESFE_RS05395
uniprot id: I3XSN5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS02180
gene id: 768672:DESFE_RS02180
uniprot id: I3XQW7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

768672:DESFE RS00620
gene id: 768672:DESFE_RS00620
uniprot id: I3XQ10
names: Similarity
messages: Belongs to the group II decarboxylase family.

768672:DESFE RS05635
gene id: 768672:DESFE_RS05635
uniprot id: I3XSS9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

768672:DESFE RS06010
gene id: 768672:DESFE_RS06010
uniprot id: I3XSZ7
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

768672:DESFE RS00015
gene id: 768672:DESFE_RS00015
uniprot id: I3XPP3
names: Similarity
messages: Belongs to the UPF0215 family.

768672:DESFE RS00740
gene id: 768672:DESFE_RS00740
uniprot id: I3XQ33
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS06135
gene id: 768672:DESFE_RS06135
uniprot id: I3XT21
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

768672:DESFE RS00305
gene id: 768672:DESFE_RS00305
uniprot id: I3XPU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

768672:DESFE RS05360
gene id: 768672:DESFE_RS05360
uniprot id: I3XSM8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

768672:DESFE RS06090
gene id: 768672:DESFE_RS06090
uniprot id: I3XT12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

768672:DESFE RS01795
gene id: 768672:DESFE_RS01795
uniprot id: I3XQP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS05045
gene id: 768672:DESFE_RS05045
uniprot id: I3XSH6
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

768672:DESFE RS00045
gene id: 768672:DESFE_RS00045
uniprot id: I3XPP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

768672:DESFE RS00720
gene id: 768672:DESFE_RS00720
uniprot id: I3XQ29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

768672:DESFE RS03155
gene id: 768672:DESFE_RS03155
uniprot id: I3XRF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

768672:DESFE RS04590
gene id: 768672:DESFE_RS04590
uniprot id: I3XS91
names: Similarity
messages: Belongs to the UPF0045 family.

768672:DESFE RS04125
gene id: 768672:DESFE_RS04125
uniprot id: I3XS00
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

768672:DESFE RS00855
gene id: 768672:DESFE_RS00855
uniprot id: I3XQ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS00805
gene id: 768672:DESFE_RS00805
uniprot id: I3XQ45
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

768672:DESFE RS06120
gene id: 768672:DESFE_RS06120
uniprot id: I3XT18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

768672:DESFE RS00865
gene id: 768672:DESFE_RS00865
uniprot id: I3XQ56
names: Similarity
messages: Belongs to the PstS family.

768672:DESFE RS03280
gene id: 768672:DESFE_RS03280
uniprot id: I3XRI3
names: Similarity
messages: Belongs to the UPF0252 family.

768672:DESFE RS01790
gene id: 768672:DESFE_RS01790
uniprot id: I3XQP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS04910
gene id: 768672:DESFE_RS04910
uniprot id: I3XSE9
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

768672:DESFE RS05175
gene id: 768672:DESFE_RS05175
uniprot id: I3XSJ6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS03365
gene id: 768672:DESFE_RS03365
uniprot id: I3XRK0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS02240
gene id: 768672:DESFE_RS02240
uniprot id: I3XQX7
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS00780
gene id: 768672:DESFE_RS00780
uniprot id: I3XQ40
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

768672:DESFE RS02280
gene id: 768672:DESFE_RS02280
uniprot id: I3XQY5
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

768672:DESFE RS01555
gene id: 768672:DESFE_RS01555
uniprot id: I3XQJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

768672:DESFE RS06105
gene id: 768672:DESFE_RS06105
uniprot id: I3XT15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

768672:DESFE RS01940
gene id: 768672:DESFE_RS01940
uniprot id: I3XQS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

768672:DESFE RS02880
gene id: 768672:DESFE_RS02880
uniprot id: I3XRA4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

768672:DESFE RS05200
gene id: 768672:DESFE_RS05200
uniprot id: I3XSK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

768672:DESFE RS04385
gene id: 768672:DESFE_RS04385
uniprot id: I3XS49
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

768672:DESFE RS04850
gene id: 768672:DESFE_RS04850
uniprot id: I3XSE1
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

768672:DESFE RS00950
gene id: 768672:DESFE_RS00950
uniprot id: I3XQ73
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS02520
gene id: 768672:DESFE_RS02520
uniprot id: I3XR32
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

768672:DESFE RS01700
gene id: 768672:DESFE_RS01700
uniprot id: I3XQM3
names: Similarity
messages: Belongs to the HypE family.

768672:DESFE RS03260
gene id: 768672:DESFE_RS03260
uniprot id: I3XRH9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

768672:DESFE RS02775
gene id: 768672:DESFE_RS02775
uniprot id: I3XR84
names: Similarity
messages: Belongs to the AOR/FOR family.

768672:DESFE RS03005
gene id: 768672:DESFE_RS03005
uniprot id: I3XRC9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

768672:DESFE RS07415
gene id: 768672:DESFE_RS07415
uniprot id: I3XTQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

768672:DESFE RS07410
gene id: 768672:DESFE_RS07410
uniprot id: I3XTQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

768672:DESFE RS07160
gene id: 768672:DESFE_RS07160
uniprot id: I3XTK7
names: Function
messages: Probably involved in the biogenesis of the ribosome.

768672:DESFE RS02440
gene id: 768672:DESFE_RS02440
uniprot id: I3XR17
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS02135
gene id: 768672:DESFE_RS02135
uniprot id: I3XQV9
names: Similarity
messages: Belongs to the Nth/MutY family.

768672:DESFE RS07230
gene id: 768672:DESFE_RS07230
uniprot id: I3XTM0
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

768672:DESFE RS03245
gene id: 768672:DESFE_RS03245
uniprot id: I3XRH6
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

768672:DESFE RS06040
gene id: 768672:DESFE_RS06040
uniprot id: I3XT02
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

768672:DESFE RS07305
gene id: 768672:DESFE_RS07305
uniprot id: I3XTN6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

768672:DESFE RS06840
gene id: 768672:DESFE_RS06840
uniprot id: I3XTE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

768672:DESFE RS02770
gene id: 768672:DESFE_RS02770
uniprot id: I3XR83
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03420
gene id: 768672:DESFE_RS03420
uniprot id: I3XRL1
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS04455
gene id: 768672:DESFE_RS04455
uniprot id: I3XS64
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

768672:DESFE RS01800
gene id: 768672:DESFE_RS01800
uniprot id: I3XQP3
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

768672:DESFE RS06485
gene id: 768672:DESFE_RS06485
uniprot id: I3XT82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

768672:DESFE RS03535
gene id: 768672:DESFE_RS03535
uniprot id: I3XRN4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

768672:DESFE RS07280
gene id: 768672:DESFE_RS07280
uniprot id: I3XTN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

768672:DESFE RS03630
gene id: 768672:DESFE_RS03630
uniprot id: I3XRQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

768672:DESFE RS02940
gene id: 768672:DESFE_RS02940
uniprot id: I3XRB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

768672:DESFE RS07340
gene id: 768672:DESFE_RS07340
uniprot id: I3XTP3
names: Similarity
messages: Belongs to the MEMO1 family.

768672:DESFE RS04265
gene id: 768672:DESFE_RS04265
uniprot id: I3XS28
names: Similarity
messages: Belongs to the UPF0111 family.

768672:DESFE RS00175
gene id: 768672:DESFE_RS00175
uniprot id: I3XPS1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

768672:DESFE RS00400
gene id: 768672:DESFE_RS00400
uniprot id: I3XPW4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

768672:DESFE RS06155
gene id: 768672:DESFE_RS06155
uniprot id: I3XT25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS03640
gene id: 768672:DESFE_RS03640
uniprot id: I3XRQ5
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

768672:DESFE RS04390
gene id: 768672:DESFE_RS04390
uniprot id: I3XS50
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

768672:DESFE RS06765
gene id: 768672:DESFE_RS06765
uniprot id: I3XTD5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

768672:DESFE RS03515
gene id: 768672:DESFE_RS03515
uniprot id: I3XRN0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

768672:DESFE RS05385
gene id: 768672:DESFE_RS05385
uniprot id: I3XSN3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS01475
gene id: 768672:DESFE_RS01475
uniprot id: I3XQH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS02945
gene id: 768672:DESFE_RS02945
uniprot id: I3XRB7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

768672:DESFE RS00350
gene id: 768672:DESFE_RS00350
uniprot id: I3XPV4
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

768672:DESFE RS05500
gene id: 768672:DESFE_RS05500
uniprot id: I3XSQ5
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

768672:DESFE RS03225
gene id: 768672:DESFE_RS03225
uniprot id: I3XRH2
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS04160
gene id: 768672:DESFE_RS04160
uniprot id: I3XS07
names: Similarity
messages: Belongs to the UPF0111 family.

768672:DESFE RS02725
gene id: 768672:DESFE_RS02725
uniprot id: I3XR75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

768672:DESFE RS03080
gene id: 768672:DESFE_RS03080
uniprot id: I3XRE3
names: Similarity
messages: Belongs to the UPF0282 family.

768672:DESFE RS02080
gene id: 768672:DESFE_RS02080
uniprot id: I3XQU8
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

768672:DESFE RS05670
gene id: 768672:DESFE_RS05670
uniprot id: I3XST6
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03355
gene id: 768672:DESFE_RS03355
uniprot id: I3XRJ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

768672:DESFE RS04000
gene id: 768672:DESFE_RS04000
uniprot id: I3XRX3
names: Similarity
messages: Belongs to the HerA family.

768672:DESFE RS06650
gene id: 768672:DESFE_RS06650
uniprot id: I3XTB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

768672:DESFE RS02705
gene id: 768672:DESFE_RS02705
uniprot id: I3XR71
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS04640
gene id: 768672:DESFE_RS04640
uniprot id: I3XS99
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS00170
gene id: 768672:DESFE_RS00170
uniprot id: I3XPS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

768672:DESFE RS02105
gene id: 768672:DESFE_RS02105
uniprot id: I3XQV3
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

768672:DESFE RS06130
gene id: 768672:DESFE_RS06130
uniprot id: I3XT20
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

768672:DESFE RS02780
gene id: 768672:DESFE_RS02780
uniprot id: I3XR85
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

768672:DESFE RS04430
gene id: 768672:DESFE_RS04430
uniprot id: I3XS59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

768672:DESFE RS04965
gene id: 768672:DESFE_RS04965
uniprot id: I3XSG0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

768672:DESFE RS07350
gene id: 768672:DESFE_RS07350
uniprot id: I3XTP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

768672:DESFE RS05315
gene id: 768672:DESFE_RS05315
uniprot id: I3XSM0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS05990
gene id: 768672:DESFE_RS05990
uniprot id: I3XSZ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

768672:DESFE RS00725
gene id: 768672:DESFE_RS00725
uniprot id: I3XQ30
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

768672:DESFE RS01600
gene id: 768672:DESFE_RS01600
uniprot id: I3XQK3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

768672:DESFE RS03120
gene id: 768672:DESFE_RS03120
uniprot id: I3XRF1
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

768672:DESFE RS01505
gene id: 768672:DESFE_RS01505
uniprot id: I3XQI4
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

768672:DESFE RS01705
gene id: 768672:DESFE_RS01705
uniprot id: I3XQM4
names: Similarity
messages: Belongs to the HupF/HypC family.

768672:DESFE RS03690
gene id: 768672:DESFE_RS03690
uniprot id: I3XRR3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

768672:DESFE RS06545
gene id: 768672:DESFE_RS06545
uniprot id: I3XT94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

768672:DESFE RS07400
gene id: 768672:DESFE_RS07400
uniprot id: I3XTQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

768672:DESFE RS01745
gene id: 768672:DESFE_RS01745
uniprot id: I3XQN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS01375
gene id: 768672:DESFE_RS01375
uniprot id: I3XQF7
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

768672:DESFE RS06640
gene id: 768672:DESFE_RS06640
uniprot id: I3XTB1
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

768672:DESFE RS05030
gene id: 768672:DESFE_RS05030
uniprot id: I3XSH3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

768672:DESFE RS06805
gene id: 768672:DESFE_RS06805
uniprot id: I3XTE1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

768672:DESFE RS03920
gene id: 768672:DESFE_RS03920
uniprot id: I3XRV7
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

768672:DESFE RS05460
gene id: 768672:DESFE_RS05460
uniprot id: I3XSP7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

768672:DESFE RS05520
gene id: 768672:DESFE_RS05520
uniprot id: I3XSQ9
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03230
gene id: 768672:DESFE_RS03230
uniprot id: I3XRH3
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

768672:DESFE RS06425
gene id: 768672:DESFE_RS06425
uniprot id: I3XT70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

768672:DESFE RS05540
gene id: 768672:DESFE_RS05540
uniprot id: I3XSR3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

768672:DESFE RS00590
gene id: 768672:DESFE_RS00590
uniprot id: I3XQ04
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

768672:DESFE RS05445
gene id: 768672:DESFE_RS05445
uniprot id: I3XSP4
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

768672:DESFE RS07215
gene id: 768672:DESFE_RS07215
uniprot id: I3XTL7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

768672:DESFE RS02935
gene id: 768672:DESFE_RS02935
uniprot id: I3XRB5
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

768672:DESFE RS04330
gene id: 768672:DESFE_RS04330
uniprot id: I3XS40
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

768672:DESFE RS01385
gene id: 768672:DESFE_RS01385
uniprot id: I3XQF9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

768672:DESFE RS05755
gene id: 768672:DESFE_RS05755
uniprot id: I3XSV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

768672:DESFE RS02480
gene id: 768672:DESFE_RS02480
uniprot id: I3XR25
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

768672:DESFE RS04715
gene id: 768672:DESFE_RS04715
uniprot id: I3XSB3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

768672:DESFE RS01560
gene id: 768672:DESFE_RS01560
uniprot id: I3XQJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

768672:DESFE RS07155
gene id: 768672:DESFE_RS07155
uniprot id: I3XTK6
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

768672:DESFE RS06365
gene id: 768672:DESFE_RS06365
uniprot id: I3XT58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

768672:DESFE RS05945
gene id: 768672:DESFE_RS05945
uniprot id: I3XSY5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

768672:DESFE RS05960
gene id: 768672:DESFE_RS05960
uniprot id: I3XSY7
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

768672:DESFE RS02545
gene id: 768672:DESFE_RS02545
uniprot id: I3XR38
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS03050
gene id: 768672:DESFE_RS03050
uniprot id: I3XRD7
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS02325
gene id: 768672:DESFE_RS02325
uniprot id: I3XQZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

768672:DESFE RS06405
gene id: 768672:DESFE_RS06405
uniprot id: I3XT66
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS07030
gene id: 768672:DESFE_RS07030
uniprot id: I3XTI3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

768672:DESFE RS00010
gene id: 768672:DESFE_RS00010
uniprot id: I3XPP2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

768672:DESFE RS07300
gene id: 768672:DESFE_RS07300
uniprot id: I3XTN5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

768672:DESFE RS04650
gene id: 768672:DESFE_RS04650
uniprot id: I3XSA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

768672:DESFE RS02430
gene id: 768672:DESFE_RS02430
uniprot id: I3XR15
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

768672:DESFE RS04970
gene id: 768672:DESFE_RS04970
uniprot id: I3XSG1
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

768672:DESFE RS06410
gene id: 768672:DESFE_RS06410
uniprot id: I3XT67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

768672:DESFE RS02250
gene id: 768672:DESFE_RS02250
uniprot id: I3XQX9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

768672:DESFE RS06245
gene id: 768672:DESFE_RS06245
uniprot id: I3XT38
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS04805
gene id: 768672:DESFE_RS04805
uniprot id: I3XSD2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

768672:DESFE RS06910
gene id: 768672:DESFE_RS06910
uniprot id: I3XTG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

768672:DESFE RS03580
gene id: 768672:DESFE_RS03580
uniprot id: I3XRP3
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

768672:DESFE RS04915
gene id: 768672:DESFE_RS04915
uniprot id: I3XSF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

768672:DESFE RS06400
gene id: 768672:DESFE_RS06400
uniprot id: I3XT65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS06560
gene id: 768672:DESFE_RS06560
uniprot id: I3XT97
names: Subcellular Location Annotation
messages: Nucleus

768672:DESFE RS00960
gene id: 768672:DESFE_RS00960
uniprot id: I3XQ75
names: Similarity
messages: Belongs to the phosphohexose mutase family.

768672:DESFE RS07175
gene id: 768672:DESFE_RS07175
uniprot id: I3XTL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

768672:DESFE RS01980
gene id: 768672:DESFE_RS01980
uniprot id: I3XQS9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

768672:DESFE RS00195
gene id: 768672:DESFE_RS00195
uniprot id: I3XPS4
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

768672:DESFE RS05020
gene id: 768672:DESFE_RS05020
uniprot id: I3XSH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

768672:DESFE RS01735
gene id: 768672:DESFE_RS01735
uniprot id: I3XQN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS02530
gene id: 768672:DESFE_RS02530
uniprot id: I3XR34
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

768672:DESFE RS07125
gene id: 768672:DESFE_RS07125
uniprot id: I3XTK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

768672:DESFE RS00125
gene id: 768672:DESFE_RS00125
uniprot id: I3XPR2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

768672:DESFE RS06615
gene id: 768672:DESFE_RS06615
uniprot id: I3XTA6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

768672:DESFE RS05210
gene id: 768672:DESFE_RS05210
uniprot id: I3XSK3
names: Similarity
messages: Belongs to the peptidase U62 family.

768672:DESFE RS05925
gene id: 768672:DESFE_RS05925
uniprot id: I3XSY2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

768672:DESFE RS06085
gene id: 768672:DESFE_RS06085
uniprot id: I3XT11
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

768672:DESFE RS01080
gene id: 768672:DESFE_RS01080
uniprot id: I3XQ99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

768672:DESFE RS04925
gene id: 768672:DESFE_RS04925
uniprot id: I3XSF2
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

768672:DESFE RS04225
gene id: 768672:DESFE_RS04225
uniprot id: I3XS20
names: Similarity
messages: Belongs to the glutaredoxin family.

768672:DESFE RS00615
gene id: 768672:DESFE_RS00615
uniprot id: I3XQ09
names: Similarity
messages: Belongs to the RuvB family.

768672:DESFE RS03045
gene id: 768672:DESFE_RS03045
uniprot id: I3XRD6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

768672:DESFE RS02265
gene id: 768672:DESFE_RS02265
uniprot id: I3XQY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

768672:DESFE RS06450
gene id: 768672:DESFE_RS06450
uniprot id: I3XT75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

768672:DESFE RS02120
gene id: 768672:DESFE_RS02120
uniprot id: I3XQV6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS07250
gene id: 768672:DESFE_RS07250
uniprot id: I3XTM4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

768672:DESFE RS01120
gene id: 768672:DESFE_RS01120
uniprot id: I3XQA7
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

768672:DESFE RS05410
gene id: 768672:DESFE_RS05410
uniprot id: I3XSN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS07180
gene id: 768672:DESFE_RS07180
uniprot id: I3XTL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

768672:DESFE RS04895
gene id: 768672:DESFE_RS04895
uniprot id: I3XSE6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

768672:DESFE RS06555
gene id: 768672:DESFE_RS06555
uniprot id: I3XT96
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

768672:DESFE RS03215
gene id: 768672:DESFE_RS03215
uniprot id: I3XRH0
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS01755
gene id: 768672:DESFE_RS01755
uniprot id: I3XQN4
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS06960
gene id: 768672:DESFE_RS06960
uniprot id: I3XTH0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

768672:DESFE RS06820
gene id: 768672:DESFE_RS06820
uniprot id: I3XTE4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

768672:DESFE RS06070
gene id: 768672:DESFE_RS06070
uniprot id: I3XT08
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

768672:DESFE RS00235
gene id: 768672:DESFE_RS00235
uniprot id: I3XPT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

768672:DESFE RS07040
gene id: 768672:DESFE_RS07040
uniprot id: I3XTI5
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

768672:DESFE RS04710
gene id: 768672:DESFE_RS04710
uniprot id: I3XSB2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

768672:DESFE RS03800
gene id: 768672:DESFE_RS03800
uniprot id: I3XRT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

768672:DESFE RS00380
gene id: 768672:DESFE_RS00380
uniprot id: I3XPW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

768672:DESFE RS06165
gene id: 768672:DESFE_RS06165
uniprot id: I3XT27
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

768672:DESFE RS03555
gene id: 768672:DESFE_RS03555
uniprot id: I3XRN8
names: Similarity
messages: Belongs to the HerA family.

768672:DESFE RS06340
gene id: 768672:DESFE_RS06340
uniprot id: I3XT53
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

768672:DESFE RS05965
gene id: 768672:DESFE_RS05965
uniprot id: I3XSY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

768672:DESFE RS06300
gene id: 768672:DESFE_RS06300
uniprot id: I3XT48
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

768672:DESFE RS00540
gene id: 768672:DESFE_RS00540
uniprot id: I3XPZ4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

768672:DESFE RS04065
gene id: 768672:DESFE_RS04065
uniprot id: I3XRY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

768672:DESFE RS02715
gene id: 768672:DESFE_RS02715
uniprot id: I3XR73
names: Similarity
messages: Belongs to the UPF0200 family.

768672:DESFE RS01100
gene id: 768672:DESFE_RS01100
uniprot id: I3XQA3
names: Similarity
messages: Belongs to the thymidylate kinase family.

768672:DESFE RS06185
gene id: 768672:DESFE_RS06185
uniprot id: I3XT31
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS06655
gene id: 768672:DESFE_RS06655
uniprot id: I3XTB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

768672:DESFE RS00370
gene id: 768672:DESFE_RS00370
uniprot id: I3XPV8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

768672:DESFE RS04500
gene id: 768672:DESFE_RS04500
uniprot id: I3XS73
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

768672:DESFE RS05325
gene id: 768672:DESFE_RS05325
uniprot id: I3XSM2
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

768672:DESFE RS01020
gene id: 768672:DESFE_RS01020
uniprot id: I3XQ87
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

768672:DESFE RS06415
gene id: 768672:DESFE_RS06415
uniprot id: I3XT68
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

768672:DESFE RS01750
gene id: 768672:DESFE_RS01750
uniprot id: I3XQN3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS02030
gene id: 768672:DESFE_RS02030
uniprot id: I3XQT8
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

768672:DESFE RS05575
gene id: 768672:DESFE_RS05575
uniprot id: I3XSS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

768672:DESFE RS06760
gene id: 768672:DESFE_RS06760
uniprot id: I3XTD4
names: Similarity
messages: Belongs to the UPF0173 family.

768672:DESFE RS06800
gene id: 768672:DESFE_RS06800
uniprot id: I3XTE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

768672:DESFE RS04745
gene id: 768672:DESFE_RS04745
uniprot id: I3XSB9
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

768672:DESFE RS04665
gene id: 768672:DESFE_RS04665
uniprot id: I3XSA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

768672:DESFE RS06140
gene id: 768672:DESFE_RS06140
uniprot id: I3XT22
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

768672:DESFE RS00260
gene id: 768672:DESFE_RS00260
uniprot id: I3XPT7
names: Similarity
messages: Belongs to the eIF-2-alpha family.

768672:DESFE RS03330
gene id: 768672:DESFE_RS03330
uniprot id: I3XRJ3
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

768672:DESFE RS06440
gene id: 768672:DESFE_RS06440
uniprot id: I3XT73
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

768672:DESFE RS06370
gene id: 768672:DESFE_RS06370
uniprot id: I3XT59
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

768672:DESFE RS04780
gene id: 768672:DESFE_RS04780
uniprot id: I3XSC7
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS00955
gene id: 768672:DESFE_RS00955
uniprot id: I3XQ74
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

768672:DESFE RS04450
gene id: 768672:DESFE_RS04450
uniprot id: I3XS63
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

768672:DESFE RS01545
gene id: 768672:DESFE_RS01545
uniprot id: I3XQJ2
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

768672:DESFE RS07320
gene id: 768672:DESFE_RS07320
uniprot id: I3XTN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

768672:DESFE RS06385
gene id: 768672:DESFE_RS06385
uniprot id: I3XT62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

768672:DESFE RS00230
gene id: 768672:DESFE_RS00230
uniprot id: I3XPT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

768672:DESFE RS02475
gene id: 768672:DESFE_RS02475
uniprot id: I3XR24
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

768672:DESFE RS01775
gene id: 768672:DESFE_RS01775
uniprot id: I3XQN8
names: Subcellular Location Annotation
messages: Membrane

768672:DESFE RS06345
gene id: 768672:DESFE_RS06345
uniprot id: I3XT54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

768672:DESFE RS06925
gene id: 768672:DESFE_RS06925
uniprot id: I3XTG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

768672:DESFE RS05305
gene id: 768672:DESFE_RS05305
uniprot id: I3XSL8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

768672:DESFE RS00160
gene id: 768672:DESFE_RS00160
uniprot id: I3XPR8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

768672:DESFE RS07140
gene id: 768672:DESFE_RS07140
uniprot id: I3XTK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

768672:DESFE RS06480
gene id: 768672:DESFE_RS06480
uniprot id: I3XT81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

768672:DESFE RS00730
gene id: 768672:DESFE_RS00730
uniprot id: I3XQ31
names: Similarity
messages: Belongs to the UPF0273 family.

768672:DESFE RS06305
gene id: 768672:DESFE_RS06305
uniprot id: I3XT49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

768672:DESFE RS00515
gene id: 768672:DESFE_RS00515
uniprot id: I3XPY8
names: Similarity
messages: Belongs to the glutamine synthetase family.

768672:DESFE RS06745
gene id: 768672:DESFE_RS06745
uniprot id: I3XTD2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

768672:DESFE RS00795
gene id: 768672:DESFE_RS00795
uniprot id: I3XQ43
names: Caution
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

768672:DESFE RS04810
gene id: 768672:DESFE_RS04810
uniprot id: I3XSD3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

768672:DESFE RS06720
gene id: 768672:DESFE_RS06720
uniprot id: I3XTC8
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

768672:DESFE RS00325
gene id: 768672:DESFE_RS00325
uniprot id: I3XPU9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

768672:DESFE RS03250
gene id: 768672:DESFE_RS03250
uniprot id: I3XRH7
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

768672:DESFE RS05505
gene id: 768672:DESFE_RS05505
uniprot id: I3XSQ6
names: Similarity
messages: Belongs to the UPF0216 family.